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Valentina Svicher

Research Profile

Physiology

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Molecular Sequence Data

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Sequence Analysis, DNA

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Publications

TOP 3
R Salpini; Cesare Sarrecchia; Valentina Svicher; M Visca; Michela Pollicita; S Romano; C Alteri; Massimo Andreoni; Mario Angelico; V Cento; G M De Sanctis; Guido Gubertini; Valeria Micheli; Giustino Parruti; Carlo Federico Perno
Snapshot on drug-resistance rate and profiles in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practice.
Mengjie Chen; Giosuè Costa; Chang Liu; Yang Liu; Francesco Ortuso; Lucia Parrotta; Carlo Federico Perno; Valentina Svicher; Stefano Alcaro; Claudia Alteri; Anna Artese; Jing Zhang
Detecting and understanding genetic and structural features in HIV-1 B subtype V3 underlying HIV-1 co-receptor usage.
Charlotte Charpentier; Claudia Alteri; Françoise Brun-Vézinet; Vincent Calvez; Francesca Ceccherini-Silberstein; Philippe Flandre; Sidonie Lambert-Niclot; Anne-Geneviève Marcelin; Carlo Federico Perno; Alexandre Storto; Valentina Svicher; Diane Descamps
Description of the L76V resistance protease mutation in HIV-1 B and "non-B" subtypes.

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All Publications

2013: R Salpini; Cesare Sarrecchia; Valentina Svicher; M Visca; Michela Pollicita; S Romano; C Alteri; Massimo Andreoni; Mario Angelico; V Cento; G M De Sanctis; Guido Gubertini; Valeria Micheli; Giustino Parruti; Carlo Federico Perno
Snapshot on drug-resistance rate and profiles in patients with chronic hepatitis B receiving nucleos(t)ide analogues in clinical practice.
Journal of medical virology 2013;85(6):996-1004.
2013: Mengjie Chen; Giosuè Costa; Chang Liu; Yang Liu; Francesco Ortuso; Lucia Parrotta; Carlo Federico Perno; Valentina Svicher; Stefano Alcaro; Claudia Alteri; Anna Artese; Jing Zhang
Detecting and understanding genetic and structural features in HIV-1 B subtype V3 underlying HIV-1 co-receptor usage.
Bioinformatics (Oxford, England) 2013;29(4):451-60.
2013: Charlotte Charpentier; Claudia Alteri; Françoise Brun-Vézinet; Vincent Calvez; Francesca Ceccherini-Silberstein; Philippe Flandre; Sidonie Lambert-Niclot; Anne-Geneviève Marcelin; Carlo Federico Perno; Alexandre Storto; Valentina Svicher; Diane Descamps
Description of the L76V resistance protease mutation in HIV-1 B and "non-B" subtypes.
PloS one 2013;8(1):e54381.
2013: Valentina Svicher; Giuliano Rizzardini; Gabriella Rozera; Maria Mercedes Santoro; Isabella Abbate; Massimo Andreoni; Andrea Antinori; Daniele Armenia; Alessandro Bruselles; Maria Rosaria Capobianchi; Francesca Ceccherini-Silberstein; Valeria Cento; Lavinia Fabeni; Federica Forbici; Caterina Gori; Giuseppe Ippolito; Alessandra Latini; Valeria Micheli; Guido Palamara; Carlo Federico Perno
The genotypic false positive rate determined by V3 population sequencing can predict the burden of HIV-1 CXCR4-using species detected by pyrosequencing.
PloS one 2013;8(1):e53603.
2013: Valeria Cento; Antonella d'Arminio Monforte; Giuseppe Maria De Sanctis; Salvatore Dimonte; Guido Gubertini; Yue Han; Roberta Longo; Francesco Mazzotta; Valeria Micheli; Carmen Mirabelli; Carlo Federico Perno; Romina Salpini; Alberto Spanò; Martina Bernassola; Ada Bertoli; Giuseppina Cappiello; Francesca Ceccherini-Silberstein; Pascale Trimoulet; Jens Verheyen; Xin Xin Zhang; Valentina Svicher
Overlapping structure of hepatitis B virus (HBV) genome and immune selection pressure are critical forces modulating HBV evolution.
The Journal of general virology 2013;94(Pt 1):143-9.
2012: Salvatore Dimonte; Fabio Mercurio; Muhammed Babakir-Mina; Francesca Ceccherini-Silberstein; Domenico Di Pinto; Valentina Svicher; Carlo Federico Perno
Selected amino acid changes in HIV-1 subtype-C gp41 are associated with specific gp120(V3) signatures in the regulation of co-receptor usage.
Virus research 2012;168(1-2):73-83.
2012: M M Santoro; M Surdo; Valentina Svicher; M Santoro; M Andreoni; G Angarano; A Antinori; Daniele Armenia; E Balestra; A Bertoli; Francesca Ceccherini-Silberstein; Luca Dori; L Fabeni; Federica Forbici; E Girardi; Caterina Gori; Pasquale Narciso; Guido Palamara; C F Perno
The lowest X4 Geno2Pheno false-positive rate is associated with greater CD4 depletion in HIV-1 infected patients.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 2012;18(8):E289-98.
2012: Laura Ceccarelli; Carlo Federico Perno; Alessandra Ricciardi; Romina Salpini; Loredana Sarmati; Massimo Andreoni; Ada Bertoli; P Sordillo; Valentina Svicher; Cesare Sarrecchia
Late hepatitis B virus reactivation after lamivudine prophylaxis interruption in an anti-HBs-positive and anti-HBc-negative patient treated with rituximab-containing therapy.
The Journal of infection 2012;65(2):180-3.
2012: Valeria Cento; Marco Ciotti; Giosuè Costa; Daniele Di Paolo; Salvatore Dimonte; Fabio Mercurio; Carmen Mirabelli; Lucia Parrotta; Carlo Federico Perno; Romina Salpini; Cesare Sarrecchia; Valentina Svicher; Stefano Alcaro; Massimo Andreoni; Mario Angelico; Anna Artese; Ada Bertoli; Francesca Ceccherini-Silberstein
HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors.
PloS one 2012;7(7):e39652.
2012: Francesc Cunyat; Marta Curriu; Elisabet García; Silvia Marfil; Nuria Pérez-Alvárez; Carlo Federico Perno; Valentina Svicher; Julià Blanco; Bonaventura Clotet; Cecilia Cabrera
The HR2 polymorphism N140I in the HIV-1 gp41 combined with the HR1 V38A mutation is associated with a less cytopathic phenotype.
Retrovirology 2012;9():15.
2012: Salvatore Dimonte; Fabio Mercurio; Carlo Federico Perno; Valentina Svicher; Francesca Ceccherini-Silberstein
Genetic and structural analysis of HIV-1 Rev responsive element related to V38A and T18A enfuvirtide resistance mutations.
Intervirology 2012;55(5):385-90.
2011: Stefano Alcaro; Claudia Alteri; Anna Artese; Ada Bertoli; Vincent Calvez; Francesca Ceccherini-Silberstein; Giosuè Costa; Diane Descamps; Philippe Flandre; Federica Forbici; Anne-Genevieve Marcelin; Bernard Masquelier; Francesco Ortuso; Lucia Parrotta; Carlo Federico Perno; Maria Mercedes Santoro; Tobias Sing; Valentina Svicher
Docking analysis and resistance evaluation of clinically relevant mutations associated with the HIV-1 non-nucleoside reverse transcriptase inhibitors nevirapine, efavirenz and etravirine.
ChemMedChem 2011;6(12):2203-13.
2011: Valentina Svicher; Pascale Trimoulet; Jens Verheyen; Michela Visca; Linda Wittkop; Xin Xin Zhang; Sara Romano; Romina Salpini; Mario Angelico; Bastian Beggel; Ada Bertoli; Giuseppina Cappiello; Francesca Ceccherini-Silberstein; Valeria Cento; Giuseppe Maria De Sanctis; Hervè Fleury; Maria Fraune; Valentina Gallinaro; Caterina Gori; Guido Gubertini; Yue Han; Roberta Longo; Nicoletta Marino; Francesco Mazzotta; Fabio Mercurio; Valeria Micheli; Carlo Federico Perno
Role of hepatitis B virus genetic barrier in drug-resistance and immune-escape development.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2011;43(12):975-83.
2011: R Salpini; Cesare Sarrecchia; F Scopelliti; A Spanò; Valentina Svicher; G Rizzardini; Mario Angelico; A Bertoli; T Cappiello; V Cento; G M De Sanctis; Caterina Gori; Valeria Micheli; Carlo Federico Perno
Characterization of drug-resistance mutations in HBV D-genotype chronically infected patients, naïve to antiviral drugs.
Antiviral research 2011;92(2):382-5.
2011: Claudia Alteri; Andrea Antinori; Barbara Bartolini; Alessandro Bruselles; Maria Rosaria Capobianchi; Francesca Ceccherini-Silberstein; Federica Forbici; Enrico Girardi; Caterina Gori; Pasquale Narciso; Nicoletta Orchi; Guido Palamara; Gabriella Rozera; Maria Mercedes Santoro; Valentina Svicher; Valerio Tozzi; Isabella Abbate; Carlo Federico Perno
'Sentinel' mutations in standard population sequencing can predict the presence of HIV-1 reverse transcriptase major mutations detectable only by ultra-deep pyrosequencing.
The Journal of antimicrobial chemotherapy 2011;66(11):2615-23.
2011: Salvatore Dimonte; Carlo Federico Perno; Romina Salpini; Valentina Svicher; Francesca Ceccherini-Silberstein; Muhammed Babakir-Mina
HIV-2 A-subtype gp125c₂-v₃-c₃ mutations and their association with CCR5 and CXCR4 tropism.
Archives of virology 2011;156(11):1943-51.
2011: Ilaria Lenci; Fabio Marcuccilli; Carlo Federico Perno; Valentina Svicher; Laura Tariciotti; Giuseppe Tisone; Marco Ciotti; Daniele Di Paolo; Mario Angelico
Safety of complete and sustained prophylaxis withdrawal in patients liver-transplanted for HBV-related cirrhosis at low risk of HBV recurrence.
Journal of hepatology 2011;55(3):587-93.
2011: Cesare Sarrecchia; P Sordillo; Valentina Svicher; Antonio Volpi; A Bertoli; L Ceccarelli; Carlo Federico Perno; R Salpini; Massimo Andreoni
Successful switch to tenofovir after suboptimal response to entecavir in an immunocompromised patient with chronic hepatitis B and without genotypic hepatitis B virus resistance.
Infection 2011;39(4):367-70.
2011: Stefano Alcaro; Claudia Alteri; Anna Artese; Francesca Ceccherini-Silberstein; Giosuè Costa; Francesco Ortuso; Lucia Parrotta; Carlo Federico Perno; Valentina Svicher
Molecular and structural aspects of clinically relevant mutations related to the approved non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2011;14(3):141-9.
2011: Valentina Svicher; Emanuela Balestra; Valeria Cento; Loredana Sarmati; Luca Dori; Ina Vandenbroucke; Roberta D'Arrigo; Anna Rita Buonomini; Herwig Van Marck; Matteo Surdo; Patrizia Saccomandi; Wendy Mostmans; Jeroen Aerssens; Stefano Aquaro; Lieven J Stuyver; Massimo Andreoni; Francesca Ceccherini-Silberstein; Carlo Federico Perno
HIV-1 dual/mixed tropic isolates show different genetic and phenotypic characteristics and response to maraviroc in vitro.
Antiviral research 2011;90(1):42-53.
2011: Annapaola Callegaro; Valentina Svicher; Claudia Alteri; Alessandra Lo Presti; Daniela Valenti; Antonio Goglio; Marco Salemi; Eleonora Cella; Carlo Federico Perno; Massimo Ciccozzi; Franco Maggiolo
Epidemiological network analysis in HIV-1 B infected patients diagnosed in Italy between 2000 and 2008.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2011;11(3):624-32.
2011: Valentina Svicher; Maurizio Zazzi; Jing Maria Zhang; Stefano Alcaro; Claudia Alteri; Massimo Andreoni; Andrea Antinori; Anna Artese; Francesca Ceccherini-Silberstein; Massimo Clementi; Giosuè Costa; Roberta D'Arrigo; Adriano Lazzarin; Fabio Mercurio; Giorgio Palu; Carlo Federico Perno
Identification and structural characterization of novel genetic elements in the HIV-1 V3 loop regulating coreceptor usage.
Antiviral therapy 2011;16(7):1035-45.
2011: Salvatore Dimonte; Fabio Mercurio; Carlo Federico Perno; Valentina Svicher; Roberta D'Arrigo; Francesca Ceccherini-Silberstein
Selected amino acid mutations in HIV-1 B subtype gp41 are associated with specific gp120v₃ signatures in the regulation of co-receptor usage.
Retrovirology 2011;8():33.
2010: Valentina Svicher; Claudia Alteri; Caterina Gori; Romina Salpini; Fabbio Marcuccilli; Ada Bertoli; Roberta Longo; Martina Bernassola; Valentina Gallinaro; Sara Romano; Michela Visca; Antonella Ursitti; Marcello Feasi; Valeria Micheli; Mario Angelico; Giovanni Cassola; Giustino Parruti; Guido Gubertini; Giuseppe Maria De Sanctis; Francesca Ceccherini-Silberstein; Giuseppina Cappiello; Alberto Spanò; Carlo Federico Perno
Lamivudine-resistance mutations can be selected even at very low levels of hepatitis B viraemia.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2010;42(12):902-7.
2010: Francesca Ceccherini-Silberstein; Isabelle Malet; Lavinia Fabeni; Salvatore Dimonte; Valentina Svicher; Roberta D'Arrigo; Anna Artese; Giosuè Costa; Sara Bono; Stefano Alcaro; Antonella d'Arminio Monforte; Christine Katlama; Vincent Calvez; Andrea Antinori; Anne-Genevieve Marcelin; Carlo Federico Perno
Specific HIV-1 integrase polymorphisms change their prevalence in untreated versus antiretroviral-treated HIV-1-infected patients, all naive to integrase inhibitors.
The Journal of antimicrobial chemotherapy 2010;65(11):2305-18.
2010: Valentina Svicher; Claudia Alteri; Anna Artese; Federica Forbici; Maria Mercedes Santoro; Dominique Schols; Kristel Van Laethem; Stefano Alcaro; Giosuè Costa; Chiara Tommasi; Mauro Zaccarelli; Pasquale Narciso; Andrea Antinori; Francesca Ceccherini-Silberstein; Jan Balzarini; Carlo Federico Perno
Different evolution of genotypic resistance profiles to emtricitabine versus lamivudine in tenofovir-containing regimens.
Journal of acquired immune deficiency syndromes (1999) 2010;55(3):336-44.
2009: Stefano Alcaro; Anna Artese; Francesca Ceccherini-Silberstein; Francesco Ortuso; Carlo Federico Perno; Tobias Sing; Valentina Svicher
Molecular dynamics and free energy studies on the wild-type and mutated HIV-1 protease complexed with four approved drugs: mechanism of binding and drug resistance.
Journal of chemical information and modeling 2009;49(7):1751-61.
2009: Valentina Svicher; Claudia Alteri; Roberta D'Arrigo; Alessandro Laganà; Maria Trignetti; Sergio Lo Caputo; Anna Paola Callegaro; Franco Maggiolo; Francesco Mazzotta; Alfredo Ferro; Salvatore Dimonte; Stefano Aquaro; Giovanni Di Perri; Stefano Bonora; Chiara Tommasi; Maria Paola Trotta; Pasquale Narciso; Andrea Antinori; Carlo Federico Perno; Francesca Ceccherini-Silberstein
Treatment with the fusion inhibitor enfuvirtide influences the appearance of mutations in the human immunodeficiency virus type 1 regulatory protein rev.
Antimicrobial agents and chemotherapy 2009;53(7):2816-23.
2009: Valentina Svicher; Caterina Gori; Maria Trignetti; Michela Visca; Valeria Micheli; Martina Bernassola; Romina Salpini; Guido Gubertini; Roberta Longo; Fosca Niero; Francesca Ceccherini-Silberstein; Giuseppe Maria De Sanctis; Alberto Spanò; Giuseppina Cappiello; Carlo Federico Perno
The profile of mutational clusters associated with lamivudine resistance can be constrained by HBV genotypes.
Journal of hepatology 2009;50(3):461-70.
2009: Claudia Alteri; Valentina Svicher; Caterina Gori; Roberta D'Arrigo; Massimo Ciccozzi; Francesca Ceccherini-Silberstein; Marina Selleri; Stefano Aviani Bardacci; Massimo Giuliani; Paola Elia; Paola Scognamiglio; Roberta Balzano; Nicoletta Orchi; Enrico Girardi; Carlo Federico Perno
Characterization of the patterns of drug-resistance mutations in newly diagnosed HIV-1 infected patients naïve to the antiretroviral drugs.
BMC infectious diseases 2009;9():111.
2009: Maria Trignetti; Tobias Sing; Valentina Svicher; Maria Mercedes Santoro; Federica Forbici; Roberta D'Arrigo; Maria Concetta Bellocchi; Mario Santoro; Patrizia Marconi; Mauro Zaccarelli; Maria Paola Trotta; Rita Bellagamba; Pasquale Narciso; Andrea Antinori; Thomas Lengauer; Carlo Federico Perno; Francesca Ceccherini-Silberstein
Dynamics of NRTI resistance mutations during therapy interruption.
AIDS research and human retroviruses 2009;25(1):57-64.
2008: Valentina Svicher; Stefano Aquaro; Roberta D'Arrigo; Anna Artese; Salvatore Dimonte; Stefano Alcaro; Maria Mercedes Santoro; Giovanni Di Perri; Sergio Lo Caputo; Rita Bellagamba; Mauro Zaccarelli; Ubaldo Visco-Comandini; Andrea Antinori; Pasquale Narciso; Francesca Ceccherini-Silberstein; Carlo Federico Perno
Specific enfuvirtide-associated mutational pathways in HIV-1 Gp41 are significantly correlated with an increase in CD4(+) cell count, despite virological failure.
The Journal of infectious diseases 2008;197(10):1408-18.
2008: Stefano Aquaro; Valentina Svicher; Luigi Ronga; Carlo F Perno; Michela Pollicita
HIV-1-associated dementia during HAART therapy.
Recent patents on CNS drug discovery 2008;3(1):23-33.
2007: Francesca Ceccherini-Silberstein; Valentina Svicher; Tobias Sing; Anna Artese; Maria Mercedes Santoro; Federica Forbici; Ada Bertoli; Stefano Alcaro; Guido Palamara; Antonella d'Arminio Monforte; Jan Balzarini; Andrea Antinori; Thomas Lengauer; Carlo Federico Perno
Characterization and structural analysis of novel mutations in human immunodeficiency virus type 1 reverse transcriptase involved in the regulation of resistance to nonnucleoside inhibitors.
Journal of virology 2007;81(20):11507-19.
2006: Stefano Aquaro; Valentina Svicher; Carlo Federico Perno
Does residual virus replication during successful HAART lead to HIV-1 genetic evolution?
Journal of HIV therapy 2006;11(4):84-8.
2006: Stefano Aquaro; Valentina Svicher; Dominique Schols; Michela Pollicita; Andrea Antinori; Jan Balzarini; Carlo Federico Perno
Mechanisms underlying activity of antiretroviral drugs in HIV-1-infected macrophages: new therapeutic strategies.
Journal of leukocyte biology 2006;80(5):1103-10.
2006: Carlo Federico Perno; Valentina Svicher; Francesca Ceccherini-Silberstein
Novel drug resistance mutations in HIV: recognition and clinical relevance.
AIDS reviews 2006;8(4):179-90.
2006: Stefano Aquaro; Roberta D'Arrigo; Valentina Svicher; Giovanni Di Perri; Sergio Lo Caputo; Ubaldo Visco-Comandini; Mario Santoro; Ada Bertoli; Francesco Mazzotta; Stefano Bonora; Valerio Tozzi; Rita Bellagamba; Mauro Zaccarelli; Pasquale Narciso; Andrea Antinori; Carlo Federico Perno
Specific mutations in HIV-1 gp41 are associated with immunological success in HIV-1-infected patients receiving enfuvirtide treatment.
The Journal of antimicrobial chemotherapy 2006;58(4):714-22.
2006: Carlo Federico Perno; Valentina Svicher; Dominique Schols; Michela Pollicita; Jan Balzarini; Stefano Aquaro
Therapeutic strategies towards HIV-1 infection in macrophages.
Antiviral research 2006;71(2-3):293-300.
2006: Valentina Svicher; Tobias Sing; Maria Mercedes Santoro; Federica Forbici; Fátima Rodríguez-Barrios; Ada Bertoli; Niko Beerenwinkel; Maria Concetta Bellocchi; Federico Gago; Antonella d'Arminio Monforte; Andrea Antinori; Thomas Lengauer; Francesca Ceccherini-Silberstein; Carlo Federico Perno
Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors.
Journal of virology 2006;80(14):7186-98.
2006: Maria Mercedes Santoro; Valentina Svicher; Caterina Gori; Mauro Zaccarelli; Valerio Tozzi; Federica Forbici; Roberta D'Arrigo; Maria Paola Trotta; Maria Concetta Bellocchi; Ubaldo Visco-Comandini; Alessandra Cenci; Ada Bertoli; Pasquale Narciso; Andrea Antinori; Carlo Federico Perno; Francesca Ceccherini-Silberstein
Temporal characterization of drug resistance associated mutations in HIV-1 protease and reverse transcriptase in patients failing antiretroviral therapy.
The new microbiologica 2006;29(2):89-100.
2005: Francesca Ceccherini-Silberstein; Federico Gago; Maria Santoro; Caterina Gori; Valentina Svicher; Fátima Rodríguez-Barrios; Roberta D'Arrigo; Massimo Ciccozzi; Ada Bertoli; Antonella d'Arminio Monforte; Jan Balzarini; Andrea Antinori; Carlo Federico Perno
High sequence conservation of human immunodeficiency virus type 1 reverse transcriptase under drug pressure despite the continuous appearance of mutations.
Journal of virology 2005;79(16):10718-29.
2005: Maria Concetta Bellocchi; Federica Forbici; leonardo Palombi; Caterina Gori; Elisabeth Coelho; Valentina Svicher; Roberta D'Arrigo; Leonardo Emberti Gialloreti; Susanna Ceffa; Fulvio Erba; Maria Cristina Marazzi; Francesca Ceccherini Silberstein; Carlo Federico Perno
Subtype analysis and mutations to antiviral drugs in HIV-1-infected patients from Mozambique before initiation of antiretroviral therapy: results from the DREAM programme.
Journal of medical virology 2005;76(4):452-8.
2005: Stefano Aquaro; Valentina Svicher; Francesca Ceccherini-Silberstein; Alessandra Cenci; Fabbio Marcuccilli; Sara Giannella; Luisa Marcon; Raffaele Caliò; Jan Balzarini; Carlo Federico Perno
Limited development and progression of resistance of HIV-1 to the nucleoside analogue reverse transcriptase inhibitor lamivudine in human primary macrophages.
The Journal of antimicrobial chemotherapy 2005;55(6):872-8.
2005: Valentina Svicher; Francesca Ceccherini-Silberstein; Fulvio Erba; Maria Santoro; Caterina Gori; Maria Concetta Bellocchi; Sara Giannella; Maria Paola Trotta; Antonella d'Arminio Monforte; Andrea Antinori; Carlo Federico Perno
Novel human immunodeficiency virus type 1 protease mutations potentially involved in resistance to protease inhibitors.
Antimicrobial agents and chemotherapy 2005;49(5):2015-25.
2004: Maria Santoro; Francesca Ceccherini-Silberstein; Caterina Gori; Valentina Svicher; Federica Forbici; Maria Concetta Bellocchi; Roberta D'Arrigo; Ada Bertoli; Sara Giannella; Maria Paola Trotta; Sandro Bonfigli; Andrea Antinori; Carlo Federico Perno
Temporal change in the use of genotypic resistance testing over the years 1999--2003.
The new microbiologica 2004;27(2 Suppl 1):141-4.