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Kunchithapadam Swaminathan

Research Profile

Procedures

X Ray Crystallography

Concepts & Ideas

Genes & Molecular Sequences

Amino Acid Sequences

Chemicals & Drugs

Living Beings

Mycobacterium tuberculosis

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Physiology

Mutagenesis, Site-Directed

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Publications

TOP 3
Chacko Jobichen; Kuntal Pal; Kunchithapadam Swaminathan
Crystal structure of mouse RhoA:GTPγS complex in a centered lattice.
Pankaj Kumar Giri; Fan Jing-Song; Gautam Sethi; Muthu K Shanmugam; Jeak Ling Ding; Kunchithapadam Swaminathan; J Sivaraman
NMR structure of Carcinoscorpius rotundicauda thioredoxin-related protein 16 and its role in regulating transcription factor NF-κB activity.
Dileep Vasudevan; Aigen Fu; Sheng Luan; Kunchithapadam Swaminathan
Crystal structure of Arabidopsis cyclophilin38 reveals a previously uncharacterized immunophilin fold and a possible autoinhibitory mechanism.

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All Publications

2012: Chacko Jobichen; Kuntal Pal; Kunchithapadam Swaminathan
Crystal structure of mouse RhoA:GTPγS complex in a centered lattice.
Journal of structural and functional genomics 2012;13(4):241-5.
2012: Pankaj Kumar Giri; Fan Jing-Song; Gautam Sethi; Muthu K Shanmugam; Jeak Ling Ding; Kunchithapadam Swaminathan; J Sivaraman
NMR structure of Carcinoscorpius rotundicauda thioredoxin-related protein 16 and its role in regulating transcription factor NF-κB activity.
The Journal of biological chemistry 2012;287(35):29417-28.
2012: Dileep Vasudevan; Aigen Fu; Sheng Luan; Kunchithapadam Swaminathan
Crystal structure of Arabidopsis cyclophilin38 reveals a previously uncharacterized immunophilin fold and a possible autoinhibitory mechanism.
The Plant cell 2012;24(6):2666-74.
2012: Stig Tollefsen; Xi Chen; Kinya Hotta; Irimpan I Mathews; Bjørg Simonsen; Ludvig M Sollid; Kunchithapadam Swaminathan; Chu-Young Kim
Structural and functional studies of trans-encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) protein molecule.
The Journal of biological chemistry 2012;287(17):13611-9.
2012: Kinya Hotta; Kendall N Houk; Xi Chen; Hao Li; Irimpan I Mathews; Atsushi Minami; Hideaki Oikawa; Robert S Paton; Kunchithapadam Swaminathan; Kenji Watanabe; Chu-Young Kim
Enzymatic catalysis of anti-Baldwin ring closure in polyether biosynthesis.
Nature 2012;483(7389):355-8.
2012: Kunchithapadam Swaminathan
Frequency distribution of the reduced unit cells of centred lattices from the Protein Data Bank.
Acta crystallographica. Section A, Foundations of crystallography 2012;68(Pt 2):295-7.
2012: Reetu Sharma; Mara Florea; Werner M Nau; Kunchithapadam Swaminathan
Validation of drug-like inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase using nuclear magnetic resonance (1H NMR).
PloS one 2012;7(9):e45947.
2012: Shiva Kumar; Kuntal Pal; Shikha Sharma; Pushpa Agrawal; Mohamed Suhail Alam; Ganesh Srinivasan Anand; Chandni Arora; Suguna Badireddy; Saurabh K Garg; Kunchithapadam Swaminathan
Interaction of Mycobacterium tuberculosis RshA and SigH is mediated by salt bridges.
PloS one 2012;7(8):e43676.
2012: Reetu Sharma; Roopa Kothapalli; Antonius M J Van Dongen; Kunchithapadam Swaminathan
Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase.
PloS one 2012;7(3):e33521.
2011: Fengxia Liu; Junhui Xiong; Sundaramurthy Kumar; Chunyan Yang; Shengxiang Ge; Shaowei Li; Ningshao Xia; Kunchithapadam Swaminathan
Structural and biophysical characterization of Mycobacterium tuberculosis dodecin Rv1498A.
Journal of structural biology 2011;175(1):31-8.
2011: Suguna Badireddy; Gao Yunfeng; Mark Ritchie; Pearl Akamine; Jian Wu; Choel W Kim; Susan S Taylor; Lin Qingsong; Kunchithapadam Swaminathan; Ganesh S Anand
Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design.
Molecular & cellular proteomics : MCP 2011;10(3):M110.004390.
2011: Sunil Kumar Tewary; Toshiro Oda; Amy Kendall; Wen Bian; Gerald Stubbs; Sek-Man Wong; Kunchithapadam Swaminathan
Structure of hibiscus latent singapore virus by fiber diffraction: a nonconserved his122 contributes to coat protein stability.
Journal of molecular biology 2011;406(3):516-26.
2011: Cho Yeow Koh; Sundramurthy Kumar; Jun Mizuguchi; Patricia A Nuttall; Uvaraj P Radhakrishnan; Kunchithapadam Swaminathan; Takayuki Imamura; Sadaaki Iwanaga; Pudur Jagadeeswaran; Maria Kazimirova; Seongcheol Kim; R Manjunatha Kini
Crystal structure of thrombin in complex with S-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors.
PloS one 2011;6(10):e26367.
2011: Shiva Kumar; Augen Pioszak; Chenghai Zhang; Kunchithapadam Swaminathan; H Eric Xu
Crystal structure of the PAC1R extracellular domain unifies a consensus fold for hormone recognition by class B G-protein coupled receptors.
PloS one 2011;6(5):e19682.
2010: Kuntal Pal; Kunchithapadam Swaminathan; H Eric Xu; Augen A Pioszak
Structural basis for hormone recognition by the Human CRFR2{alpha} G protein-coupled receptor.
The Journal of biological chemistry 2010;285(51):40351-61.
2010: Kuntal Pal; Shiva Kumar; Shikha Sharma; Saurabh Kumar Garg; Mohammad Suhail Alam; H Eric Xu; Pushpa Agrawal; Kunchithapadam Swaminathan
Crystal structure of full-length Mycobacterium tuberculosis H37Rv glycogen branching enzyme: insights of N-terminal beta-sandwich in substrate specificity and enzymatic activity.
The Journal of biological chemistry 2010;285(27):20897-903.
2010: Pankaj Kumar Giri; Xuhua Tang; Saravanan Thangamani; Rajesh T Shenoy; Jeak Ling Ding; Kunchithapadam Swaminathan; J Sivaraman
Modifying the substrate specificity of Carcinoscorpius rotundicauda serine protease inhibitor domain 1 to target thrombin.
PloS one 2010;5(12):e15258.
2009: Asha M Balakrishna; Anand M Saxena; Henry Yu-Keung Mok; Kunchithapadam Swaminathan
Structural basis of typhoid: Salmonella typhi type IVb pilin (PilS) and cystic fibrosis transmembrane conductance regulator interaction.
Proteins 2009;77(2):253-61.
2009: Qian Zhang; Hong Y Wang; Gauri Bhutani; Xiaobin Liu; Michele Paessler; John W Tobias; Donald Baldwin; Kunchithapadam Swaminathan; Michael C Milone; Mariusz A Wasik
Lack of TNFalpha expression protects anaplastic lymphoma kinase-positive T-cell lymphoma (ALK+ TCL) cells from apoptosis.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(37):15843-8.
2008: Tien-Chye Tan; Benjamin N Mijts; Kunchithapadam Swaminathan; Bharat K. C. Patel; Christina Divne
Crystal structure of the polyextremophilic alpha-amylase AmyB from Halothermothrix orenii: details of a productive enzyme-substrate complex and an N domain with a role in binding raw starch.
Journal of molecular biology 2008;378(4):852-70.
2007: Gayathri Gopalan; Maung-Maung Thwin; Ponnampalam Gopalakrishnakone; Kunchithapadam Swaminathan
Structural and pharmacological comparison of daboiatoxin from Daboia russelli siamensis with viperotoxin F and vipoxin from other vipers.
Acta crystallographica. Section D, Biological crystallography 2007;63(Pt 6):722-9.
2006: Gayathri Gopalan; Zengyong He; Kevin P Battaile; Sheng Luan; Kunchithapadam Swaminathan
Structural comparison of oxidized and reduced FKBP13 from Arabidopsis thaliana.
Proteins 2006;65(4):789-95.
2006: Gayathri Gopalan; Sidharth Chopra; Anand Ranganathan; Kunchithapadam Swaminathan
Crystal structure of uncleaved L-aspartate-alpha-decarboxylase from Mycobacterium tuberculosis.
Proteins 2006;65(4):796-802.
2006: Asha M Balakrishna; Yvonne Yih-Wan Tan; Henry Yu-Keung Mok; Anand M Saxena; Kunchithapadam Swaminathan
Crystallization and preliminary X-ray diffraction analysis of Salmonella typhi PilS.
Acta crystallographica. Section F, Structural biology and crystallization communications 2006;62(Pt 10):1024-6.
2006: Neelamegam Sivakumar; Nan Li; Julian W Tang; Bharat K. C. Patel; Kunchithapadam Swaminathan
Crystal structure of AmyA lacks acidic surface and provide insights into protein stability at poly-extreme condition.
FEBS letters 2006;580(11):2646-52.
2005: Dileep Vasudevan; Gayathri Gopalan; Zengyong He; Sheng Luan; Kunchithapadam Swaminathan
Expression, purification, crystallization and preliminary X-ray diffraction analysis of Arabidopsis thaliana cyclophilin 38 (AtCyp38).
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 12):1087-9.
2005: Shee-Mei Lok; Rong Gao; Morgane Rouault; Gérard Lambeau; Ponnampalam Gopalakrishnakone; Kunchithapadam Swaminathan
Structure and function comparison of Micropechis ikaheka snake venom phospholipase A2 isoenzymes.
The FEBS journal 2005;272(5):1211-20.
2005: Frederick Huynh; Tien-Chye Tan; Kunchithapadam Swaminathan; Bharat K. C. Patel
Expression, purification and preliminary crystallographic analysis of sucrose phosphate synthase (SPS) from Halothermothrix orenii.
Acta crystallographica. Section F, Structural biology and crystallization communications 2005;61(Pt 1):116-7.
2004: Gayathri Gopalan; Zengyong He; Yves Balmer; Patrick S Romano; Rajeev Gupta; Annie Héroux; Bob B Buchanan; Kunchithapadam Swaminathan; Sheng Luan
Structural analysis uncovers a role for redox in regulating FKBP13, an immunophilin of the chloroplast thylakoid lumen.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(38):13945-50.
2004: Sandeep Saxena; Ping Yuan; Suman Kumar Dhar; Takeshi Senga; David Takeda; Howard Robinson; Sally Kornbluth; Kunchithapadam Swaminathan; Anindya Dutta
A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition.
Molecular cell 2004;15(2):245-58.
2003: Tien-Chye Tan; Yvette Y Yien; Bharat K. C. Patel; Benjamin N Mijts; Kunchithapadam Swaminathan
Crystallization of a novel alpha-amylase, AmyB, from the thermophilic halophile Halothermothrix orenii.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2257-8.
2003: Daohai Zhang; Nan Li; Shee-Mei Lok; Lian-Hui Zhang; Kunchithapadam Swaminathan
Isomaltulose synthase (PalI) of Klebsiella sp. LX3. Crystal structure and implication of mechanism.
The Journal of biological chemistry 2003;278(37):35428-34.
2003: Ping Yuan; Gregory Jedd; Desigan Kumaran; Subramanyam Swaminathan; Helen Shio; David Hewitt; Nam-Hai Chua; Kunchithapadam Swaminathan
A HEX-1 crystal lattice required for Woronin body function in Neurospora crassa.
Nature structural biology 2003;10(4):264-70.
2003: Daohai Zhang; Nan Li; Kunchithapadam Swaminathan; Lian-Hui Zhang
A motif rich in charged residues determines product specificity in isomaltulose synthase.
FEBS letters 2003;534(1-3):151-5.
2003: Nan Li; Daohai Zhang; Lian-Hui Zhang; Kunchithapadam Swaminathan
Expression, crystallization and preliminary X-ray analysis of isomaltulose synthase (PalI) from Klebsiella sp. LX3.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 1):150-1.
2002: Nan Li; Bharat K. C. Patel; Benjamin N Mijts; Kunchithapadam Swaminathan
Crystallization of an alpha-amylase, AmyA, from the thermophilic halophile Halothermothrix orenii.
Acta crystallographica. Section D, Biological crystallography 2002;58(Pt 12):2125-6.