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MD Swedberg

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KE Andersen; J Lau; BF Lundt; H Petersen; PO Huusfeldt; PD Suzdak; MD Swedberg
Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.
KE Andersen; J L Sørensen; J Lau; BF Lundt; H Petersen; PO Huusfeldt; PD Suzdak; MD Swedberg
Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.
Thøger Rasmussen; Anders Fink-Jensen; Per Sauerberg; MD Swedberg; C Thomsen; MJ Sheardown; Lone Jeppesen; David O Calligaro; Neil DeLapp; CA Whitesitt; JS Ward; Harlan E Shannon; Frank P Bymaster
The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance.

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All Publications

2001: KE Andersen; J Lau; BF Lundt; H Petersen; PO Huusfeldt; PD Suzdak; MD Swedberg
Synthesis of novel GABA uptake inhibitors. Part 6: preparation and evaluation of N-Omega asymmetrically substituted nipecotic acid derivatives.
Bioorganic & medicinal chemistry 2001;9(11):2773-85.
2001: KE Andersen; J L Sørensen; J Lau; BF Lundt; H Petersen; PO Huusfeldt; PD Suzdak; MD Swedberg
Synthesis of novel gamma-aminobutyric acid (GABA) uptake inhibitors. 5.(1) Preparation and structure-activity studies of tricyclic analogues of known GABA uptake inhibitors.
Journal of medicinal chemistry 2001;44(13):2152-63.
2001: Thøger Rasmussen; Anders Fink-Jensen; Per Sauerberg; MD Swedberg; C Thomsen; MJ Sheardown; Lone Jeppesen; David O Calligaro; Neil DeLapp; CA Whitesitt; JS Ward; Harlan E Shannon; Frank P Bymaster
The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance.
Schizophrenia research 2001;49(1-2):193-201.
2000: Thøger Rasmussen; Per Sauerberg; EB Nielsen; MD Swedberg; C Thomsen; MJ Sheardown; Lone Jeppesen; David O Calligaro; Neil DeLapp; CA Whitesitt; JS Ward; Harlan E Shannon; Frank P Bymaster; Anders Fink-Jensen
Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice.
European journal of pharmacology 2000;402(3):241-6.
2000: Harlan E Shannon; Kurt Rasmussen; Frank P Bymaster; J C Hart; Steven C Peters; MD Swedberg; Lone Jeppesen; MJ Sheardown; Per Sauerberg; Anders Fink-Jensen
Xanomeline, an M(1)/M(4) preferring muscarinic cholinergic receptor agonist, produces antipsychotic-like activity in rats and mice.
Schizophrenia research 2000;42(3):249-59.
1999: KE Andersen; J L Sørensen; PO Huusfeldt; Lars Knutsen; J Lau; BF Lundt; H Petersen; PD Suzdak; MD Swedberg
Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates.
Journal of medicinal chemistry 1999;42(21):4281-91.
1999: Lars Knutsen; KE Andersen; J Lau; BF Lundt; R F Henry; H E Morton; L Naerum; H Petersen; H Stephensen; PD Suzdak; MD Swedberg; C Thomsen; P O Sørensen
Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.
Journal of medicinal chemistry 1999;42(18):3447-62.
1999: Harlan E Shannon; J C Hart; Frank P Bymaster; David O Calligaro; Neil DeLapp; Charles H Mitch; JS Ward; Anders Fink-Jensen; Per Sauerberg; Lone Jeppesen; MJ Sheardown; MD Swedberg
Muscarinic receptor agonists, like dopamine receptor antagonist antipsychotics, inhibit conditioned avoidance response in rats.
The Journal of pharmacology and experimental therapeutics 1999;290(2):901-7.
1999: Frank P Bymaster; Harlan E Shannon; Kurt Rasmussen; Neil DeLapp; JS Ward; David O Calligaro; Charles H Mitch; CA Whitesitt; TS Ludvigsen; MJ Sheardown; MD Swedberg; Thøger Rasmussen; Preben Olesen; Lone Jeppesen; Per Sauerberg; Anders Fink-Jensen
Potential role of muscarinic receptors in schizophrenia.
Life sciences 1999;64(6-7):527-34.
1998: Per Sauerberg; Lone Jeppesen; Preben Olesen; Thøger Rasmussen; MD Swedberg; MJ Sheardown; Anders Fink-Jensen; C Thomsen; H Thøgersen; Karin Rimvall; JS Ward; David O Calligaro; Neil DeLapp; Frank P Bymaster; Harlan E Shannon
Muscarinic agonists with antipsychotic-like activity: structure-activity relationships of 1,2,5-thiadiazole analogues with functional dopamine antagonist activity.
Journal of medicinal chemistry 1998;41(22):4378-84.
1998: Frank P Bymaster; Harlan E Shannon; Kurt Rasmussen; Neil DeLapp; Charles H Mitch; JS Ward; David O Calligaro; TS Ludvigsen; MJ Sheardown; Preben Olesen; MD Swedberg; Per Sauerberg; Anders Fink-Jensen
Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane .
European journal of pharmacology 1998;356(2-3):109-19.
1998: Preben Olesen; MD Swedberg; Karin Rimvall
3-(5-Alkylamino-4-isoxazolyl)-1,2,5,6-tetrahydropyridines: a novel class of central nicotinic receptor ligands.
Bioorganic & medicinal chemistry 1998;6(9):1623-9.
1998: T Rasmussen; MD Swedberg
Reinforcing effects of nicotinic compounds: intravenous self-administration in drug-naive mice.
Pharmacology, biochemistry, and behavior 1998;60(2):567-73.
1998: JS Ward; L Merritt; David O Calligaro; Frank P Bymaster; Harlan E Shannon; Charles H Mitch; CA Whitesitt; D Brunsting; MJ Sheardown; Preben Olesen; MD Swedberg; Lone Jeppesen; Per Sauerberg
1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists.
Journal of medicinal chemistry 1998;41(3):379-92.
1998: Per Sauerberg; Preben Olesen; MJ Sheardown; Karin Rimvall; H Thøgersen; Harlan E Shannon; BD Sawyer; JS Ward; Frank P Bymaster; Neil DeLapp; David O Calligaro; MD Swedberg
Conformationally constrained analogues of the muscarinic agonist 3-(4-(methylthio)-1,2,5-thiadiazol-3-yl)-1,2,5,6-tetrahydro-1-methylpyr idine. Synthesis, receptor affinity, and antinociceptive activity.
Journal of medicinal chemistry 1998;41(1):109-16.
1997: Harlan E Shannon; MJ Sheardown; Frank P Bymaster; David O Calligaro; Neil DeLapp; J Gidda; Charles H Mitch; BD Sawyer; Peter stengel; JS Ward; David T Wong; Preben Olesen; PD Suzdak; Per Sauerberg; MD Swedberg
Pharmacology of butylthio[2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity.
The Journal of pharmacology and experimental therapeutics 1997;281(2):884-94.
1997: MD Swedberg; MJ Sheardown; Per Sauerberg; Preben Olesen; PD Suzdak; Kristian Tage Hansen; Frank P Bymaster; JS Ward; Charles H Mitch; David O Calligaro; Neil DeLapp; Harlan E Shannon
Butylthio[2.2.2] (NNC 11-1053/LY297802): an orally active muscarinic agonist analgesic.
The Journal of pharmacology and experimental therapeutics 1997;281(2):876-83.
1997: MJ Sheardown; Harlan E Shannon; MD Swedberg; PD Suzdak; Frank P Bymaster; Preben Olesen; Charles H Mitch; JS Ward; Per Sauerberg
M1 receptor agonist activity is not a requirement for muscarinic antinociception.
The Journal of pharmacology and experimental therapeutics 1997;281(2):868-75.
1997: Charles H Mitch; T J Brown; Frank P Bymaster; David O Calligaro; Donna K Dieckman; L Merrit; Steven C Peters; Steven J Quimby; Harlan E Shannon; L A Shipley; JS Ward; K Hansen; Preben Olesen; Per Sauerberg; MJ Sheardown; MD Swedberg; PD Suzdak; B Greenwood
Muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome.
Journal of medicinal chemistry 1997;40(4):538-46.
1997: Harlan E Shannon; DE Womer; Frank P Bymaster; David O Calligaro; N C DeLapp; Charles H Mitch; JS Ward; CA Whitesitt; MD Swedberg; MJ Sheardown; Anders Fink-Jensen; Preben Olesen; Karin Rimvall; Per Sauerberg
In vivo pharmacology of butylthio[2.2.2] (LY297802 / NNC11-1053), an orally acting antinociceptive muscarinic agonist.
Life sciences 1997;60(13-14):969-76.
1997: EB Nielsen; J B Hansen; F C Grłnvald; MD Swedberg; MA Scheideler
NNC-19-1228 and NNC 22-0031, novel neuroleptics with a "mesolimbic-selective" behavioral profile.
Psychopharmacology 1997;129(2):168-78.
1996: H C Jackson; H C Hansen; M Kristiansen; PD Suzdak; H Klitgaard; Martin Judge; MD Swedberg
Anticonvulsant profile of the imidazoquinazolines NNC 14-0185 and NNC 14-0189 in rats and mice.
European journal of pharmacology 1996;308(1):21-30.
1995: Per Sauerberg; Preben Olesen; MJ Sheardown; PD Suzdak; Harlan E Shannon; Frank P Bymaster; David O Calligaro; Charles H Mitch; JS Ward; MD Swedberg
Muscarinic agonists as analgesics. Antinociceptive activity versus M1 activity: SAR of alkylthio-TZTP's and related 1,2,5-thiadiazole analogs.
Life sciences 1995;56(11-12):807-14.
1992: MD Swedberg; Harlan E Shannon; B Nickel; Steven R Goldberg
D-16949 (anpirtoline): a novel serotonergic (5-HT1B) psychotherapeutic agent assessed by its discriminative effects in the rat.
The Journal of pharmacology and experimental therapeutics 1992;263(3):1015-22.
1992: Anders Fink-Jensen; PD Suzdak; MD Swedberg; Martin Judge; L Hansen; P G Nielsen
The gamma-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats.
European journal of pharmacology 1992;220(2-3):197-201.
1992: PD Suzdak; MD Swedberg; KE Andersen; Lars Knutsen; C Braestrup
In vivo labeling of the central GABA uptake carrier with 3H-Tiagabine.
Life sciences 1992;51(24):1857-68.
1989: K Takada; MD Swedberg; Steven R Goldberg; Jonathan L Katz
Discriminative stimulus effects of intravenous l-nicotine and nicotine analogs or metabolites in squirrel monkeys.
Psychopharmacology 1989;99(2):208-12.
1988: MD Swedberg; Harlan E Shannon; B Nickel; Steven R Goldberg
Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat.
The Journal of pharmacology and experimental therapeutics 1988;246(3):1067-74.