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Man-Sun Sy

Research Profile

Chemicals & Drugs

Living Beings

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Prion Diseases

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Chae Kim; Qingzhong Kong; Janis Blevins; Wei Chen; Mark Cohen; Yvonne Cohen; Tracy Haldiman; Krystyna Surewicz; Witold K Surewicz; Man-Sun Sy; Glenn C Telling; Jiri G Safar
Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).
Chae Kim; Man-Sun Sy; Janis Blevins; Wei Chen; Mark Cohen; Yvonne Cohen; Tracy Haldiman; Jiri G Safar
Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt-Jakob disease are indicator of progression rate.
Kang R Cho; Yu Huang; Shuiliang Yu; Shaoman Yin; Marco Plomp; S Roger Qiu; Rajamani Lakshminarayanan; Janet Moradian-Oldak; Man-Sun Sy; James J De Yoreo
A multistage pathway for human prion protein aggregation in vitro: from multimeric seeds to β-oligomers and nonfibrillar structures.

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2012: Chae Kim; Qingzhong Kong; Janis Blevins; Wei Chen; Mark Cohen; Yvonne Cohen; Tracy Haldiman; Krystyna Surewicz; Witold K Surewicz; Man-Sun Sy; Glenn C Telling; Jiri G Safar
Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).
PLoS pathogens 2012;8(8):e1002835.
2011: Chae Kim; Man-Sun Sy; Janis Blevins; Wei Chen; Mark Cohen; Yvonne Cohen; Tracy Haldiman; Jiri G Safar
Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt-Jakob disease are indicator of progression rate.
PLoS pathogens 2011;7(9):e1002242.
2011: Kang R Cho; Yu Huang; Shuiliang Yu; Shaoman Yin; Marco Plomp; S Roger Qiu; Rajamani Lakshminarayanan; Janet Moradian-Oldak; Man-Sun Sy; James J De Yoreo
A multistage pathway for human prion protein aggregation in vitro: from multimeric seeds to β-oligomers and nonfibrillar structures.
Journal of the American Chemical Society 2011;133(22):8586-93.
2011: Man-Sun Sy; Lan Zhou; Sean F Altekruse; Marc T Goodman; Brenda Y Hernandez; Stephen M Hewitt; Chaoyang Li; Charles F Lynch; Maria Sibug Saber; Wei Xin
Association of prion protein expression with pancreatic adenocarcinoma survival in the SEER residual tissue repository.
Cancer biomarkers : section A of Disease markers 2011;10(6):251-8.
2010: C Li; W Xin; Man-Sun Sy
Binding of pro-prion to filamin A: by design or an unfortunate blunder.
Oncogene 2010;29(39):5329-45.
2010: Chaoyang Li; Shuiliang Yu; Fumihiko Nakamura; Olli Pentikäinen; Neena Singh; Shaoman Yin; Wei Xin; Man-Sun Sy
Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis.
The Journal of biological chemistry 2010;285(39):30328-39.
2010: Fei Wang; Shaoman Yin; Xinhe Wang; Liang Zha; Man-Sun Sy; Jiyan Ma
Role of the highly conserved middle region of prion protein (PrP) in PrP-lipid interaction.
Biochemistry 2010;49(37):8169-76.
2010: Man-Sun Sy; Chaoyang Li; Shuiliang Yu; Wei Xin
The fatal attraction between pro-prion and filamin A: prion as a marker in human cancers.
Biomarkers in medicine 2010;4(3):453-64.
2010: Wen-Quan Zou; Jan P M Langeveld; Xiangzhu Xiao; Shugui Chen; Patrick L McGeer; Jue Yuan; Michael C Payne; Hae-Eun Kang; John McGeehan; Man-Sun Sy; Neil S Greenspan; David Kaplan; Gong-Xian Wang; Piero Parchi; Edward Hoover; Geoff Kneale; Glenn Telling; Witold K Surewicz; Qingzhong Kong; Jian-Ping Guo
PrP conformational transitions alter species preference of a PrP-specific antibody.
The Journal of biological chemistry 2010;285(18):13874-84.
2010: Dola Das; Xiu Luo; Ajay Singh; Yaping Gu; Soumya Ghosh; Chinmay K Mukhopadhyay; Shu G Chen; Man-Sun Sy; Qingzhong Kong; Neena Singh
Paradoxical role of prion protein aggregates in redox-iron induced toxicity.
PloS one 2010;5(7):e11420.
2009: Jianxin Tan; Guozhang Mao; Mei-Zhen Cui; Bruce Lamb; Man-Sun Sy; Xuemin Xu
Residues at P2-P1 positions of epsilon- and zeta-cleavage sites are important in formation of beta-amyloid peptide.
Neurobiology of disease 2009;36(3):453-60.
2009: Man-Sun Sy
The saga of prion: to cut or not to cut.
Cell research 2009;19(9):1039-40.
2009: Chaoyang Li; Shuiliang Yu; Fumihiko Nakamura; Shaoman Yin; Jinghua Xu; Amber A Petrolla; Neena Singh; Alan M Tartakoff; Derek W Abbott; Wei Xin; Man-Sun Sy
Binding of pro-prion to filamin A disrupts cytoskeleton and correlates with poor prognosis in pancreatic cancer.
The Journal of clinical investigation 2009;119(9):2725-36.
2008: Shuiliang Yu; Shaoman Yin; Nancy Pham; Poki Wong; Shin-Chung Kang; Robert B Petersen; Chaoyang Li; Man-Sun Sy
Ligand binding promotes prion protein aggregation--role of the octapeptide repeats.
The FEBS journal 2008;275(22):5564-75.
2008: Jianxin Tan; Guozhang Mao; Mei-Zhen Cui; Shin-Chung Kang; Bruce Lamb; Boon-Seng Wong; Man-Sun Sy; xuemin xu
Effects of gamma-secretase cleavage-region mutations on APP processing and Abeta formation: interpretation with sequential cleavage and alpha-helical model.
Journal of neurochemistry 2008;107(3):722-33.
2008: Shaoman Yin; Xingjun Fan; Shuiliang Yu; Chaoyang Li; Man-Sun Sy
Binding of recombinant but not endogenous prion protein to DNA causes DNA internalization and expression in mammalian cells.
The Journal of biological chemistry 2008;283(37):25446-54.
2008: Nancy Pham; Shaoman Yin; Shuiliang Yu; Poki Wong; Shin-Chung Kang; Chaoyang Li; Man-Sun Sy
Normal cellular prion protein with a methionine at position 129 has a more exposed helix 1 and is more prone to aggregate.
Biochemical and biophysical research communications 2008;368(4):875-81.
2008: Tim J Fitzmaurice; david burke; Lee Hopkins; Sujeong Yang; Shuiliang Yu; Man-Sun Sy; Alana M Thackray; Raymond Bujdoso
The stability and aggregation of ovine prion protein associated with classical and atypical scrapie correlates with the ease of unwinding of helix-2.
The Biochemical journal 2008;409(2):367-75.
2007: Marguerite Prior; Sylvain Lehmann; Man-Sun Sy; Brendan Molloy; Hilary E M McMahon
Cyclodextrins inhibit replication of scrapie prion protein in cell culture.
Journal of virology 2007;81(20):11195-207.
2007: Joel C Watts; Bettina Drisaldi; Vivian Ng; Jing Yang; Bob Strome; Patrick Horne; Man-Sun Sy; Larry Yoong; Rebecca Young; Peter Mastrangelo; Catherine Bergeron; Paul E Fraser; George A Carlson; Howard T J Mount; Gerold Schmitt-Ulms; David Westaway
The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.
The EMBO journal 2007;26(17):4038-50.
2007: Chaoyang Li; Poki Wong; Tao Pan; Fan Xiao; Shaoman Yin; Binggong Chang; Shin-Chung Kang; James Ironside; Man-Sun Sy
Normal cellular prion protein is a ligand of selectins: binding requires Le(X) but is inhibited by sLe(X).
The Biochemical journal 2007;406(2):333-41.
2007: Shuiliang Yu; Yunjian Zhang; Shu Li; Man-Sun Sy; Shenggang Sun; Po Tien; Gengfu Xiao
Early onset fatal familial insomnia with rapid progression in a Chinese family line.
Journal of neurology 2007;254(9):1300-1.
2007: Shaoman Yin; Nancy Pham; Shuiliang Yu; Chaoyang Li; Poki Wong; Binggong Chang; Shin-Chung Kang; Emiliano Biasini; Po Tien; David A Harris; Man-Sun Sy
Human prion proteins with pathogenic mutations share common conformational changes resulting in enhanced binding to glycosaminoglycans.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7546-51.
2007: Shuiliang Yu; Shaoman Yin; Chaoyang Li; Poki Wong; Binggong Chang; Fan Xiao; Shin-Chung Kang; Huimin Yan; Gengfu Xiao; Po Tien; Man-Sun Sy
Aggregation of prion protein with insertion mutations is proportional to the number of inserts.
The Biochemical journal 2007;403(2):343-51.
2007: Catherine S Adamson; Yongxiu Yao; Snezana Vasiljevic; Man-Sun Sy; Junyuan Ren; Ian M Jones
Novel single chain antibodies to the prion protein identified by phage display.
Virology 2007;358(1):166-77.
2007: Angeline Xi-Hua Goh; Chaoyang Li; Man-Sun Sy; Boon-Seng Wong
Altered prion protein glycosylation in the aging mouse brain.
Journal of neurochemistry 2007;100(3):841-54.
2007: Binggong Chang; Xin Cheng; Shaoman Yin; Tao Pan; Hongtao Zhang; Poki Wong; Shin-Chung Kang; Fan Xiao; Huimin Yan; Chaoyang Li; Lisa L Wolfe; Michael W Miller; Thomas Wisniewski; Mark I Greene; Man-Sun Sy
Test for detection of disease-associated prion aggregate in the blood of infected but asymptomatic animals.
Clinical and vaccine immunology : CVI 2007;14(1):36-43.
2006: Joanna Pankiewicz; Frances Prelli; Man-Sun Sy; Richard J Kascsak; Regina B Kascsak; Daryl Spinner; Richard I Carp; Harry C Meeker; Martin Sadowski; Thomas Wisniewski
Clearance and prevention of prion infection in cell culture by anti-PrP antibodies.
The European journal of neuroscience 2006;23(10):2635-47.
2006: Shaoman Yin; Shuiliang Yu; Chaoyang Li; Poki Wong; Binggong Chang; Fan Xiao; Shin-Chung Kang; Huimin Yan; Gengfu Xiao; Jacques Grassi; Po Tien; Man-Sun Sy
Prion proteins with insertion mutations have altered N-terminal conformation and increased ligand binding activity and are more susceptible to oxidative attack.
The Journal of biological chemistry 2006;281(16):10698-705.
2006: Nicola Franscini; Ahmed El Gedaily; Ulrich Matthey; Suzanna Franitza; Man-Sun Sy; Alexander Bürkle; Martin H Groschup; Ueli Braun; Ralph Zahn
Prion protein in milk.
PloS one 2006;1():e71.
2005: vito vetrugno; Alessio Cardinale; Ilaria Filesi; Sonia Mattei; Man-Sun Sy; Maurizio Pocchiari; Silvia Biocca
KDEL-tagged anti-prion intrabodies impair PrP lysosomal degradation and inhibit scrapie infectivity.
Biochemical and biophysical research communications 2005;338(4):1791-7.
2005: Tao Pan; Binggong Chang; Poki Wong; Chaoyang Li; Ruliang Li; Shin-Chung Kang; John D Robinson; Andrew R Thompsett; Po Tein; Shaoman Yin; Geoff Barnard; Irene McConnell; David Brown; Thomas Wisniewski; Man-Sun Sy
An aggregation-specific enzyme-linked immunosorbent assay: detection of conformational differences between recombinant PrP protein dimers and PrP(Sc) aggregates.
Journal of virology 2005;79(19):12355-64.
2005: Qingzhong Kong; Shenghai Huang; Wenquan Zou; Difernando Vanegas; Meiling Wang; Di Wu; Jue Yuan; Mengjie Zheng; Hua Bai; Huayun Deng; Ken Chen; Allen L Jenny; Katherine O'Rourke; Ermias D Belay; Lawrence B Schonberger; Robert B Petersen; Man-Sun Sy; Shu G Chen; Pierluigi Gambetti
Chronic wasting disease of elk: transmissibility to humans examined by transgenic mouse models.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(35):7944-9.
2005: Syed I A Zaidi; Sandra L Richardson; Sabina Capellari; Li Song; Mark A. Smith; Bernardino Ghetti; Man-Sun Sy; Pierluigi Gambetti; Robert B Petersen
Characterization of the F198S prion protein mutation: enhanced glycosylation and defective refolding.
Journal of Alzheimer's disease : JAD 2005;7(2):159-71; discussion 173-80.
2005: Tao Pan; Ruliang Li; Boon-Seng Wong; Shin-Chung Kang; James Ironside; Man-Sun Sy
Novel antibody-lectin enzyme-linked immunosorbent assay that distinguishes prion proteins in sporadic and variant cases of Creutzfeldt-Jakob disease.
Journal of clinical microbiology 2005;43(3):1118-26.
2005: Xinhe Wang; Fei Wang; Man-Sun Sy; Jiyan Ma
Calpain and other cytosolic proteases can contribute to the degradation of retro-translocated prion protein in the cytosol.
The Journal of biological chemistry 2005;280(1):317-25.
2005: Alessio Cardinale; Ilaria Filesi; vito vetrugno; Maurizio Pocchiari; Man-Sun Sy; Silvia Biocca
Trapping prion protein in the endoplasmic reticulum impairs PrPC maturation and prevents PrPSc accumulation.
The Journal of biological chemistry 2005;280(1):685-94.
2005: F Goñi; Elin Knudsen; Fernanda Schreiber; Henrieta Scholtzova; Joanna Pankiewicz; Richard I Carp; Harry C Meeker; Richard Rubenstein; David Brown; Man-Sun Sy; José A Chabalgoity; Einar Sigurdsson; Thomas Wisniewski
Mucosal vaccination delays or prevents prion infection via an oral route.
Neuroscience 2005;133(2):413-21.
2005: Tao Pan; Poki Wong; Binggong Chang; Chaoyang Li; Ruliang Li; Shin-Chung Kang; Thomas Wisniewski; Man-Sun Sy
Biochemical fingerprints of prion infection: accumulations of aberrant full-length and N-terminally truncated PrP species are common features in mouse prion disease.
Journal of virology 2005;79(2):934-43.
2005: Tao Pan; Ruliang Li; Shin-Chung Kang; Manuela Pastore; Boon-Seng Wong; James Ironside; Pierluigi Gambetti; Man-Sun Sy
Biochemical fingerprints of prion diseases: scrapie prion protein in human prion diseases that share prion genotype and type.
Journal of neurochemistry 2005;92(1):132-42.
2004: Bettina Drisaldi; Janaky Coomaraswamy; Peter Mastrangelo; Bob Strome; Jing Yang; Joel C Watts; M Azhar Chishti; Melissa Marvi; Otto Windl; Rosemary Ahrens; François Major; Man-Sun Sy; Hans A Kretzschmar; Paul E Fraser; Howard T J Mount; David Westaway
Genetic mapping of activity determinants within cellular prion proteins: N-terminal modules in PrPC offset pro-apoptotic activity of the Doppel helix B/B' region.
The Journal of biological chemistry 2004;279(53):55443-54.
2004: Shui-Liang Yu; Lei Jin; Man-Sun Sy; Fang-Hua Mei; Shu-Li Kang; Gui-Hong Sun; Po Tien; Fu-Sheng Wang; Gengfu Xiao
Polymorphisms of the PRNP gene in Chinese populations and the identification of a novel insertion mutation.
European journal of human genetics : EJHG 2004;12(10):867-70.
2004: Tao Pan; Ruliang Li; Shin-Chung Kang; Boon-Seng Wong; Thomas Wisniewski; Man-Sun Sy
Epitope scanning reveals gain and loss of strain specific antibody binding epitopes associated with the conversion of normal cellular prion to scrapie prion.
Journal of neurochemistry 2004;90(5):1205-17.
2004: Shao-Man Yin; Man-Sun Sy; Huai-Yi Yang; Po Tien
Interaction of Doppel with the full-length laminin receptor precursor protein.
Archives of biochemistry and biophysics 2004;428(2):165-9.
2004: Shin-Chung Kang; David Brown; Matthew Whiteman; Ruliang Li; Tao Pan; George Perry; Thomas Wisniewski; Man-Sun Sy; Boon-Seng Wong
Prion protein is ubiquitinated after developing protease resistance in the brains of scrapie-infected mice.
The Journal of pathology 2004;203(1):603-8.
2004: Shao-Man Yin; Man-Sun Sy; Tien Po
An engineered PrPsc-like molecule from the chimera of mammalian prion protein and yeast Ure2p prion-inducing domain.
Acta biochimica et biophysica Sinica 2004;36(2):128-32.
2003: Wen-Quan Zou; Sabina Capellari; Piero Parchi; Man-Sun Sy; Pierluigi Gambetti; Shu G Chen
Identification of novel proteinase K-resistant C-terminal fragments of PrP in Creutzfeldt-Jakob disease.
The Journal of biological chemistry 2003;278(42):40429-36.
2003: Taian Cui; Maki Daniels; Boon-Seng Wong; Ruliang Li; Man-Sun Sy; Judyth Sassoon; David Brown
Mapping the functional domain of the prion protein.
European journal of biochemistry / FEBS 2003;270(16):3368-76.
2003: Boon-Seng Wong; Ruliang Li; Judyth Sassoon; Shin-Chung Kang; Tong Liu; Tao Pan; Neil S Greenspan; Thomas Wisniewski; David Brown; Man-Sun Sy
Mapping the antigenicity of copper-treated cellular prion protein with the scrapie isoform.
Cellular and molecular life sciences : CMLS 2003;60(6):1224-34.
2003: Ruliang Li; Tong Liu; Fukuoka Yoshihiro; Magdalena Tary-Lehmann; Mark E Obrenovich; Haydar Kuekrek; Shin-Chung Kang; Tao Pan; Boon-Seng Wong; M Edward Medof; Man-Sun Sy
On the same cell type GPI-anchored normal cellular prion and DAF protein exhibit different biological properties.
Biochemical and biophysical research communications 2003;303(2):446-51.
2003: Gianluigi Zanusso; Cristina Casalone; Pierluigi Acutis; Elena Bozzetta; Alessia Farinazzo; Matteo Gelati; Michele Fiorini; Gianluigi Forloni; Man-Sun Sy; Salvatore Monaco; Maria Caramelli
Molecular analysis of iatrogenic scrapie in Italy.
The Journal of general virology 2003;84(Pt 4):1047-52.
2003: Shin-Chung Kang; Ruliang Li; Chuanping Wang; Tao Pan; Tong Liu; Richard Rubenstein; Geoff Barnard; Boon-Seng Wong; Man-Sun Sy
Guanidine hydrochloride extraction and detection of prion proteins in mouse and hamster prion diseases by ELISA.
The Journal of pathology 2003;199(4):534-41.
2003: Einar Sigurdsson; Man-Sun Sy; Ruliang Li; Henrieta Scholtzova; Richard J Kascsak; Regina Kascsak; Richard I Carp; Harry C Meeker; Blas Frangione; Thomas Wisniewski
Anti-prion antibodies for prophylaxis following prion exposure in mice.
Neuroscience letters 2003;336(3):185-7.
2002: Tong Liu; Ruliang Li; Tao Pan; Dacai Liu; Robert B Petersen; Boon-Seng Wong; Pierluigi Gambetti; Man-Sun Sy
Intercellular transfer of the cellular prion protein.
The Journal of biological chemistry 2002;277(49):47671-8.
2002: Tao Pan; Boon-Seng Wong; Tong Liu; Ruliang Li; Robert B Petersen; Man-Sun Sy
Cell-surface prion protein interacts with glycosaminoglycans.
The Biochemical journal 2002;368(Pt 1):81-90.
2002: Tao Pan; Ruliang Li; Boon-Seng Wong; Tong Liu; Pierluigi Gambetti; Man-Sun Sy
Heterogeneity of normal prion protein in two- dimensional immunoblot: presence of various glycosylated and truncated forms.
Journal of neurochemistry 2002;81(5):1092-101.
2002: Man-Sun Sy; Pierluigi Gambetti; Boon-Seng Wong
Human prion diseases.
The Medical clinics of North America 2002;86(3):551-71, vi-vii.
2001: Boon-Seng Wong; David Brown; Man-Sun Sy
A Yin-Yang role for metals in prion disease.
Panminerva medica 2001;43(4):283-7.
2001: Boon-Seng Wong; David Brown; Tao Pan; Matthew Whiteman; Tong Liu; X Bu; Ruliang Li; Pierluigi Gambetti; J Olesik; R Rubenstein; Man-Sun Sy
Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities.
Journal of neurochemistry 2001;79(3):689-98.
2001: Tao Pan; Monica Colucci; Boon-Seng Wong; Ruliang Li; Tong Liu; Robert B Petersen; S Chen; Pierluigi Gambetti; Man-Sun Sy
Novel differences between two human prion strains revealed by two-dimensional gel electrophoresis.
The Journal of biological chemistry 2001;276(40):37284-8.
2001: Boon-Seng Wong; Shu G Chen; Monica Colucci; Zhiliang Xie; Tao Pan; Tong Liu; Ruliang Li; Pierluigi Gambetti; Man-Sun Sy; David Brown
Aberrant metal binding by prion protein in human prion disease.
Journal of neurochemistry 2001;78(6):1400-8.
2001: Boon-Seng Wong; A J Green; Ruliang Li; Zhiliang Xie; Tao Pan; Tong Liu; Shu G Chen; Pierluigi Gambetti; Man-Sun Sy
Absence of protease-resistant prion protein in the cerebrospinal fluid of Creutzfeldt-Jakob disease.
The Journal of pathology 2001;194(1):9-14.
2001: Boon-Seng Wong; Tong Liu; Derek Paisley; Ruliang Li; Tao Pan; S G Chen; George Perry; Robert B Petersen; Mark A. Smith; David W Melton; Pierluigi Gambetti; David Brown; Man-Sun Sy
Induction of HO-1 and NOS in doppel-expressing mice devoid of PrP: implications for doppel function.
Molecular and cellular neurosciences 2001;17(4):768-75.
2001: Tong Liu; Theresa Zwingman; Ruliang Li; Tao Pan; Boon-Seng Wong; Robert B Petersen; Pierluigi Gambetti; Karl Herrup; Man-Sun Sy
Differential expression of cellular prion protein in mouse brain as detected with multiple anti-PrP monoclonal antibodies.
Brain research 2001;896(1-2):118-29.
2001: Tong Liu; Ruliang Li; Boon-Seng Wong; Dacai Liu; Tao Pan; Robert B Petersen; Pierluigi Gambetti; Man-Sun Sy
Normal cellular prion protein is preferentially expressed on subpopulations of murine hemopoietic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(6):3733-42.
2001: Ruliang Li; Dacai Liu; Gianluigi Zanusso; Tong Liu; John D Fayen; J H Huang; Robert B Petersen; Pierluigi Gambetti; Man-Sun Sy
The expression and potential function of cellular prion protein in human lymphocytes.
Cellular immunology 2001;207(1):49-58.
2001: Boon-Seng Wong; Tong Liu; Ruliang Li; Tao Pan; Robert B Petersen; Mark A. Smith; Pierluigi Gambetti; George Perry; Jean C Manson; David Brown; Man-Sun Sy
Increased levels of oxidative stress markers detected in the brains of mice devoid of prion protein.
Journal of neurochemistry 2001;76(2):565-72.
2000: Boon-Seng Wong; Tao Pan; Tong Liu; Ruliang Li; Robert B Petersen; I M Jones; Pierluigi Gambetti; D R Brown; Man-Sun Sy
Prion disease: A loss of antioxidant function?
Biochemical and biophysical research communications 2000;275(2):249-52.
2000: Ruliang Li; Tong Liu; Boon-Seng Wong; Tao Pan; MANUEL MORILLAS; Wieslaw Swietnicki; K O'Rourke; Pierluigi Gambetti; Witold K Surewicz; Man-Sun Sy
Identification of an epitope in the C terminus of normal prion protein whose expression is modulated by binding events in the N terminus.
Journal of molecular biology 2000;301(3):567-73.
2000: Sabina Capellari; Piero Parchi; C M Russo; Jeremy Sanford; Man-Sun Sy; Pierluigi Gambetti; Robert B Petersen
Effect of the E200K mutation on prion protein metabolism. Comparative study of a cell model and human brain.
The American journal of pathology 2000;157(2):613-22.
2000: Boon-Seng Wong; Tao Pan; Tong Liu; Ruliang Li; Pierluigi Gambetti; Man-Sun Sy
Differential contribution of superoxide dismutase activity by prion protein in vivo.
Biochemical and biophysical research communications 2000;273(1):136-9.
1999: Jean C Manson; E Jamieson; Herbert N Baybutt; Nadia L Tuzi; Rona M Barron; Irene McConnell; Robert A Somerville; James Ironside; Robert Will; Man-Sun Sy; David W Melton; James Hope; Christopher J Bostock
A single amino acid alteration (101L) introduced into murine PrP dramatically alters incubation time of transmissible spongiform encephalopathy.
The EMBO journal 1999;18(23):6855-64.
1998: Dacai Liu; Tong Liu; Man-Sun Sy
Identification of two regions in the cytoplasmic domain of CD44 through which PMA, calcium, and foskolin differentially regulate the binding of CD44 to hyaluronic acid.
Cellular immunology 1998;190(2):132-40.
1998: Gianluigi Zanusso; D Liu; S Ferrari; I Hegyi; X Yin; Adriano Aguzzi; Simone Hornemann; S Liemann; Rudi Glockshuber; Jean C Manson; P Brown; Robert B Petersen; Pierluigi Gambetti; Man-Sun Sy
Prion protein expression in different species: analysis with a panel of new mAbs.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(15):8812-6.
1998: Dacai Liu; Tong Liu; R Li; Man-Sun Sy
Mechanisms regulating the binding activity of CD44 to hyaluronic acid.
Frontiers in bioscience : a journal and virtual library 1998;3():d631-6.
1998: P Kogerman; Man-Sun Sy; Lloyd A Culp
Over-expression of human CD44s in murine 3T3 cells: selection against during primary tumorigenesis and selection for during micrometastasis.
Clinical & experimental metastasis 1998;16(1):83-93.
1997: P Kogerman; Man-Sun Sy; Lloyd A Culp
Overexpressed human CD44s promotes lung colonization during micrometastasis of murine fibrosarcoma cells: facilitated retention in the lung vasculature.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(24):13233-8.
1997: P Kogerman; Man-Sun Sy; Lloyd A Culp
Counter-selection for over-expressed human CD44s in primary tumors versus lung metastases in a mouse fibrosarcoma model.
Oncogene 1997;15(12):1407-16.
1997: Dacai Liu; Man-Sun Sy
Phorbol myristate acetate stimulates the dimerization of CD44 involving a cysteine in the transmembrane domain.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(6):2702-11.
1997: Man-Sun Sy; H Mori; Dacai Liu
CD44 as a marker in human cancers.
Current opinion in oncology 1997;9(1):108-12.
1996: Dacai Liu; D Zhang; H Mori; Man-Sun Sy
Binding of CD44 to hyaluronic acid can be induced by multiple signals and requires the CD44 cytoplasmic domain.
Cellular immunology 1996;174(1):73-83.
1996: M Nagabhushan; Thomas G Pretlow; Y J Guo; Saeid B Amini; Theresa P Pretlow; Man-Sun Sy
Altered expression of CD44 in human prostate cancer during progression.
American journal of clinical pathology 1996;106(5):647-51.
1996: P Kogerman; Man-Sun Sy; Lloyd A Culp
CD44 protein levels and its biological activity are regulated in Balb/c 3T3 fibroblasts by serum factors and by transformation with the ras but not with the sis oncogene.
Journal of cellular physiology 1996;169(2):341-9.
1996: D Liu; Eric Pearlman; Eugenia Diaconu; K Guo; H Mori; Tariq M Haqqi; Sanford Markowitz; James Willson; Man-Sun Sy
Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(15):7832-7.
1996: Tariq M Haqqi; X M Qu; D Anthony; J Ma; Man-Sun Sy
Immunization with T cell receptor V beta chain peptides deletes pathogenic T cells and prevents the induction of collagen-induced arthritis in mice.
The Journal of clinical investigation 1996;97(12):2849-58.
1996: Dacai Liu; Man-Sun Sy
A cysteine residue located in the transmembrane domain of CD44 is important in binding of CD44 to hyaluronic acid.
The Journal of experimental medicine 1996;183(5):1987-94.
1996: Man-Sun Sy; Dacai Liu; R Schiavone; J Ma; H Mori; Y Guo
Interactions between CD44 and hyaluronic acid: their role in tumor growth and metastasis.
Current topics in microbiology and immunology 1996;213 ( Pt 3)():129-53.
1996: P Kogerman; Man-Sun Sy; Lloyd A Culp
Oncogene-dependent expression of CD44 in Balb/c 3T3 derivatives: correlation with metastatic competence.
Clinical & experimental metastasis 1996;14(1):73-82.
1995: N H Zaidi; E Allay; T C Ayi; Benjamin F L Li; L L Dumenco; Man-Sun Sy; Stanton L Gerson
The immature thymocyte is protected from N-methylnitrosourea-induced lymphoma by the human MGMT-CD2 transgene.
Carcinogenesis 1995;16(5):1047-53.
1995: Tariq M Haqqi; X M Qu; Man-Sun Sy; S Banerjee
Restricted expression of T cell receptor V beta and lymphokine genes in arthritic joints of a TCR V beta a (H-2q) mouse strain-BUB/BnJ-with collagen-induced arthritis.
Autoimmunity 1995;20(3):163-70.
1994: J Ma; J H Wang; Y J Guo; Man-Sun Sy; M Bigby
In vivo treatment with anti-ICAM-1 and anti-LFA-1 antibodies inhibits contact sensitization-induced migration of epidermal Langerhans cells to regional lymph nodes.
Cellular immunology 1994;158(2):389-99.
1994: J Ma; J H Wang; Man-Sun Sy; Y J Guo; C Hauser; M Bigby
Trinitrophenol reactive T-cell hybridomas recognize antigens that require antigen processing.
The Journal of investigative dermatology 1994;103(1):42-8.
1994: Y Guo; J Ma; J Wang; X Che; J Narula; M Bigby; M Wu; Man-Sun Sy
Inhibition of human melanoma growth and metastasis in vivo by anti-CD44 monoclonal antibody.
Cancer research 1994;54(6):1561-5.
1994: Y J Guo; J H Wong; S C Lin; Alejandro Aruffo; Ivan Stamenkovic; Man-Sun Sy
Disruption of T lymphocyte reappearance in anti-Thy-1-treated animals in vivo with soluble CD44 and L-selectin molecules.
Cellular immunology 1994;154(1):202-18.
1994: Y J Guo; S C Lin; J H Wang; M Bigby; Man-Sun Sy
Palmitoylation of CD44 interferes with CD3-mediated signaling in human T lymphocytes.
International immunology 1994;6(2):213-21.
1994: Y J Guo; G Liu; X Wang; D Jin; M Wu; J Ma; Man-Sun Sy
Potential use of soluble CD44 in serum as indicator of tumor burden and metastasis in patients with gastric or colon cancer.
Cancer research 1994;54(2):422-6.
1993: Y J Guo; J Ma; J H Wong; S C Lin; H C Chang; M Bigby; Man-Sun Sy
Monoclonal anti-CD44 antibody acts in synergy with anti-CD2 but inhibits anti-CD3 or T cell receptor-mediated signaling in murine T cell hybridomas.
Cellular immunology 1993;152(1):186-99.
1993: K Nishikawa; Y J Guo; M Miyasaka; T Tamatani; A B Collins; Man-Sun Sy; Robert T McCluskey; G Andres
Antibodies to intercellular adhesion molecule 1/lymphocyte function-associated antigen 1 prevent crescent formation in rat autoimmune glomerulonephritis.
The Journal of experimental medicine 1993;177(3):667-77.
1993: James A Maclean; Z Su; Y Guo; Man-Sun Sy; Robert B Colvin; J T Wong
Anti-CD3:anti-IL-2 receptor bispecific monoclonal antibody. Targeting of activated T cells in vitro.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(4):1619-28.
1992: Man-Sun Sy; Y J Guo; Ivan Stamenkovic
Inhibition of tumor growth in vivo with a soluble CD44-immunoglobulin fusion protein.
The Journal of experimental medicine 1992;176(2):623-7.
1991: Man-Sun Sy; Y J Guo; Ivan Stamenkovic
Distinct effects of two CD44 isoforms on tumor growth in vivo.
The Journal of experimental medicine 1991;174(4):859-66.
1991: Ivan Stamenkovic; D Sgroi; Alejandro Aruffo; Man-Sun Sy; T Anderson
The B lymphocyte adhesion molecule CD22 interacts with leukocyte common antigen CD45RO on T cells and alpha 2-6 sialyltransferase, CD75, on B cells.
Cell 1991;66(6):1133-44.
1990: M Bigby; P Wang; Jose-Fernando Fierro; Man-Sun Sy
Phorbol myristate acetate-induced down-modulation of CD4 is dependent on calmodulin and intracellular calcium.
Journal of immunology (Baltimore, Md. : 1950) 1990;144(8):3111-6.
1989: M Bigby; R Vargas; Man-Sun Sy
Production of hapten-specific T cell hybridomas and their use to study the effect of ultraviolet B irradiation on the development of contact hypersensitivity.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(12):3867-72.
1989: F Stafford-Brady; E Sugiyama; D R Robinson; Man-Sun Sy; Joseph V Bonventre; E T Yeh
Defective signal transduction in CD4-CD8- T cells of lpr mice.
Cellular immunology 1989;123(2):396-404.
1989: K Yamada; R Spezialetti; A Marshak-Rothstein; Man-Sun Sy
Autoantibody in MRL/Mp-lpr/lpr mice. A monoclonal antibody specific for the abnormal T cells from mice bearing the lpr/lpr gene.
Journal of immunology (Baltimore, Md. : 1950) 1989;142(8):2702-7.
1988: K M Weston; S T Ju; C Y Lu; Man-Sun Sy
Autoreactive T cells in MRL/Mpr-lpr/lpr mice. Characterization of the lymphokines produced and analysis of antigen-presenting cells required.
Journal of immunology (Baltimore, Md. : 1950) 1988;141(6):1941-8.
1988: Man-Sun Sy; P T Wang; S T Ju; K M Weston; B Alarcon; Cox Terhorst; E T Yeh
Abnormal T cells from MRL/Mp-lpr/lpr mice do not respond to anti-T-cell-receptor antibody or tumor promoter and calcium ionophore A23187 despite the presence of the T-cell-receptor complex and protein kinase c.
Cellular immunology 1988;113(1):82-94.
1988: Man-Sun Sy; franccesca villella
Suppressor T cells, immunoglobulin and Igh restriction.
Immunological reviews 1988;101():133-48.
1988: W W Williams; Louis Falo; C Y Lu; franccesca villella; Man-Sun Sy
Effects of in vivo monoclonal anti-I-A antibody treatment in neonatal mice on intrathymic and peripheral class II antigen expression.
Cellular immunology 1988;111(1):126-38.
1987: M Bigby; T Kwan; Man-Sun Sy
Ratio of Langerhans cells to Thy-1+ dendritic epidermal cells in murine epidermis influences the intensity of contact hypersensitivity.
The Journal of investigative dermatology 1987;89(5):495-9.
1987: P T Wang; M Bigby; Man-Sun Sy
Selective down modulation of L3T4 molecules on murine thymocytes by the tumor promoter, phorbol 12-myristate 13-acetate.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(7):2157-65.
1987: K M Weston; E T Yeh; Man-Sun Sy
Autoreactivity accelerates the development of autoimmunity and lymphoproliferation in MRL/Mp-lpr/lpr mice.
Journal of immunology (Baltimore, Md. : 1950) 1987;139(3):734-42.
1986: K T Hayglass; S J Naides; C F Scott; franccesca villella; Man-Sun Sy
T cell development in B cell-deficient mice. IV. The role of B cells as antigen-presenting cells in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1986;136(3):823-9.
1985: C F Scott; M Tsurufuji; S J Naides; Man-Sun Sy
Regulation of hapten-specific T-cell response. II. Functional analysis of helper T cells and cytotoxic T cells in animals suppressed by azobenzenearsonate (ABA)-specific suppressor T cells.
Cellular immunology 1985;93(1):144-56.
1985: K T HayGlass; S J Naides; franccesca villella; Man-Sun Sy
Suppressor T-cell factor(s) display an altered pattern of Igh (immunoglobulin heavy chain locus) genetic restriction when developed in an Igh-congeneic host.
Proceedings of the National Academy of Sciences of the United States of America 1985;82(7):2133-7.
1985: K T HayGlass; S J Naides; franccesca villella; Man-Sun Sy
T cell development in B cell deficient mice. III. Restriction specificity of suppressor T cell factor(s) produced in mice treated chronically with rabbit anti-mouse mu chain antibody.
The Journal of molecular and cellular immunology : JMCI 1985;2(2):107-17.
1984: Man-Sun Sy; A Lowy; K HayGlass; C A Janeway; M Gurish; M I Greene; franccesca villella
Chronic treatment with rabbit anti-mouse mu-chain antibody alters the characteristic immunoglobulin heavy-chain restriction of murine suppressor T-cell factors.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(12):3846-50.
1984: C F Scott; M Tsurufuji; C Y Lu; R Finberg; Man-Sun Sy
Comparison of antigen-specific T cell responses in autoimmune MRL/Mp-lpr/lpr and MRL/Mp-+/+ mice.
Journal of immunology (Baltimore, Md. : 1950) 1984;132(2):633-9.
1983: C F Scott; M Tsurufuji; franccesca villella; Man-Sun Sy
Regulation of the hapten-specific T cell response. I. Preferential induction of hyporesponsiveness to the D-end of the major histocompatibility complex in the hapten-specific cytotoxic T cell response.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(5):2184-9.
1983: M Tsurufuji; franccesca villella; Man-Sun Sy
An antigen-specific signal is required for the activation of second-order suppressor T cells in the regulation of delayed-type hypersensitivity to 2,4,6-trinitrobenzene sulfonic acid.
The Journal of experimental medicine 1983;158(3):932-45.
1983: Man-Sun Sy; M Tsurufuji; R Finberg; franccesca villella
Effect of vesicular stomatitis virus (VSV) infection on the development and regulation of T cell-mediated immune responses.
Journal of immunology (Baltimore, Md. : 1950) 1983;131(1):30-6.
1982: M Takaoki; Man-Sun Sy; A Tominaga; A Lowy; M Tsurufuji; R Finberg; franccesca villella; M I Greene
I-J-restricted interactions in the generation of azobenzenearsonate-specific suppressor T cells.
The Journal of experimental medicine 1982;156(5):1325-34.
1982: Man-Sun Sy; S H Lee; M Tsurufuji; K L Rock; franccesca villella; R Finberg
Two distinct mechanisms regulate the in vivo generation of cytotoxic T cells.
The Journal of experimental medicine 1982;156(3):918-23.
1982: M I Greene; S Ratnofsky; M Takaoki; Man-Sun Sy; S Burakoff; R W Finberg
Antigen-specific suppression of cytotoxic T cell responses: an idiotype-bearing factor regulates the cytotoxic T cell response to azobenzenearsonate-coupled cells.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(3):1188-91.
1982: M Takaoki; Man-Sun Sy; B Whitaker; J Nepom; R Finberg; R N Germain; A Nisonoff; franccesca villella; M I Greene
Biologic activity of an idiotype-bearing suppressor T cell factor produced by a long-term T cell hybridoma.
Journal of immunology (Baltimore, Md. : 1950) 1982;128(1):49-53.
1982: M I Greene; M J Nelles; Man-Sun Sy; A Nisonoff
Regulation of immunity to the azobenzenearsonate hapten.
Advances in immunology 1982;32():253-300.
1981: R B Whitaker; J T Nepom; Man-Sun Sy; M Takaoki; C F Gramm; I Fox; R N Germain; M J Nelles; M I Greene; franccesca villella
Suppressor factor from a T cell hybrid inhibits delayed-type hypersensitivity responses to azobenzenearsonate.
Proceedings of the National Academy of Sciences of the United States of America 1981;78(10):6441-5.