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Brian Sykes

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Sandra E Pineda-Sanabria; Ian M Robertson; Monica X Li; Brian D Sykes
Interaction between the regulatory domain of cardiac troponin C and the acidosis-resistant cardiac troponin I A162H.
Peter M Hwang; Jonathan S Pan; Brian D Sykes
A PagP fusion protein system for the expression of intrinsically disordered proteins in Escherichia coli.
Samuel S W Szeto; Kayode S Oyedotun; Stacey N Reinke; Brian D Sykes; Bernard D Lemire
Expression of Saccharomyces cerevisiae Sdh3p and Sdh4p paralogs results in catalytically active succinate dehydrogenase isoenzymes.

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All Publications

2013: Sandra E Pineda-Sanabria; Ian M Robertson; Monica X Li; Brian D Sykes
Interaction between the regulatory domain of cardiac troponin C and the acidosis-resistant cardiac troponin I A162H.
Cardiovascular research 2013;97(3):481-9.
2012: Peter M Hwang; Jonathan S Pan; Brian D Sykes
A PagP fusion protein system for the expression of intrinsically disordered proteins in Escherichia coli.
Protein expression and purification 2012;85(1):148-51.
2012: Samuel S W Szeto; Kayode S Oyedotun; Stacey N Reinke; Brian D Sykes; Bernard D Lemire
Expression of Saccharomyces cerevisiae Sdh3p and Sdh4p paralogs results in catalytically active succinate dehydrogenase isoenzymes.
The Journal of biological chemistry 2012;287(27):22509-20.
2012: Ian M Robertson; Olga K Baryshnikova; Peter C Holmes; Monica X Li; Sandra E Pineda-Sanabria; Brian D Sykes
Elucidation of isoform-dependent pH sensitivity of troponin i by NMR spectroscopy.
The Journal of biological chemistry 2012;287(7):4996-5007.
2011: Olivier Julien; Emil F Pai; Valentyna Semenchenko; Braden Sweeting; Brian D Sykes; David S Wishart; Sandipta Acharya; Trent C Bjorndahl; Avijit Chakrabartty; Subhrangsu Chatterjee; Neil R Cashman
Relative and regional stabilities of the hamster, mouse, rabbit, and bovine prion proteins toward urea unfolding assessed by nuclear magnetic resonance and circular dichroism spectroscopies.
Biochemistry 2011;50(35):7536-45.
2011: Ian M Robertson; Robert F Boyko; Brian D Sykes
Visualizing the principal component of ¹H, ¹⁵N-HSQC NMR spectral changes that reflect protein structural or functional properties: application to troponin C.
Journal of biomolecular NMR 2011;51(1-2):115-22.
2011: Brian L Lee; Brian D Sykes; Larry Fliegel
Structural analysis of the Na+/H+ exchanger isoform 1 (NHE1) using the divide and conquer approach.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2011;89(2):189-99.
2011: Brian D Sykes
Application of NMR spectroscopy in metabolomics.
Journal of biomolecular NMR 2011;49(3-4):163-4.
2011: Olivier Julien; Pascal Mercier; Claire N Allen; Olivier Fisette; Carlos H I Ramos; Patrick Lagüe; Tharin M A Blumenschein; Brian D Sykes
Is there nascent structure in the intrinsically disordered region of troponin I?
Proteins 2011;79(4):1240-50.
2011: Erik J Saude; Christopher D Skappak; Shana Regush; Kim Cook; Amos Ben-Zvi; Allan Becker; Redwan Moqbel; Brian D Sykes; Brian H Rowe; Darryl J Adamko
Metabolomic profiling of asthma: diagnostic utility of urine nuclear magnetic resonance spectroscopy.
The Journal of allergy and clinical immunology 2011;127(3):757-64.e1-6.
2011: Sandra E Pineda-Sanabria; Ian M Robertson; Brian D Sykes
Structure of trans-resveratrol in complex with the cardiac regulatory protein troponin C.
Biochemistry 2011;50(8):1309-20.
2011: Olivier Julien; James R Beadle; Wendy C Magee; Subhrangsu Chatterjee; Karl Y Hostetler; David H Evans; Brian D Sykes
Solution structure of a DNA duplex containing the potent anti-poxvirus agent cidofovir.
Journal of the American Chemical Society 2011;133(7):2264-74.
2010: Samuel S W Szeto; Stacey N Reinke; Brian D Sykes; Bernard D Lemire
Mutations in the Saccharomyces cerevisiae succinate dehydrogenase result in distinct metabolic phenotypes revealed through (1)H NMR-based metabolic footprinting.
Journal of proteome research 2010;9(12):6729-39.
2010: Ian M Robertson; Yin-Biao Sun; Monica X Li; Brian D Sykes
A structural and functional perspective into the mechanism of Ca2+-sensitizers that target the cardiac troponin complex.
Journal of molecular and cellular cardiology 2010;49(6):1031-41.
2010: Jennifer Tzeng; Brian L Lee; Brian D Sykes; Larry Fliegel
Structural and functional analysis of transmembrane segment VI of the NHE1 isoform of the Na+/H+ exchanger.
The Journal of biological chemistry 2010;285(47):36656-65.
2010: Marta Oleszczuk; Brian D Sykes
Advances in biological NMR circa WWMR 2010 in Florence.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2010;207(1):1-7.
2010: S N Reinke; X Hu; Brian D Sykes; Bernard D Lemire
Caenorhabditis elegans diet significantly affects metabolic profile, mitochondrial DNA levels, lifespan and brood size.
Molecular genetics and metabolism 2010;100(3):274-82.
2010: Marta Oleszczuk; Ian M Robertson; Monica X Li; Brian D Sykes
Solution structure of the regulatory domain of human cardiac troponin C in complex with the switch region of cardiac troponin I and W7: the basis of W7 as an inhibitor of cardiac muscle contraction.
Journal of molecular and cellular cardiology 2010;48(5):925-33.
2009: Brian L Lee; Xiuju Li; Yongsheng Liu; Brian D Sykes; Larry Fliegel
Structural and functional analysis of extracellular loop 2 of the Na(+)/H(+) exchanger.
Biochimica et biophysica acta 2009;1788(12):2481-8.
2009: Olivier Julien; Subhrangsu Chatterjee; Angela Thiessen; Steffen P Graether; Brian D Sykes
Differential stability of the bovine prion protein upon urea unfolding.
Protein science : a publication of the Protein Society 2009;18(10):2172-82.
2009: Ian M Robertson; Monica X Li; Brian D Sykes
Solution structure of human cardiac troponin C in complex with the green tea polyphenol, (-)-epigallocatechin 3-gallate.
The Journal of biological chemistry 2009;284(34):23012-23.
2009: R Magnus N Friis; Bob P Wu; Stacey N Reinke; Darren J Hockman; Brian D Sykes; Michael C Schultz
A glycolytic burst drives glucose induction of global histone acetylation by picNuA4 and SAGA.
Nucleic acids research 2009;37(12):3969-80.
2009: Ryan M B Hoffman; Brian D Sykes
Structure of the inhibitor W7 bound to the regulatory domain of cardiac troponin C.
Biochemistry 2009;48(24):5541-52.
2009: Olivier Julien; Pascal Mercier; Melissa L Crane; Brian D Sykes
The effect of the cosolvent trifluoroethanol on a tryptophan side chain orientation in the hydrophobic core of troponin C.
Protein science : a publication of the Protein Society 2009;18(6):1165-74.
2009: Brian L Lee; Xiuju Li; Yongsheng Liu; Brian D Sykes; Larry Fliegel
Structural and functional analysis of transmembrane XI of the NHE1 isoform of the Na+/H+ exchanger.
The Journal of biological chemistry 2009;284(17):11546-56.
2009: Olivier Julien; Steffen P Graether; Brian D Sykes
Monitoring prion protein stability by NMR.
Journal of toxicology and environmental health. Part A 2009;72(17-18):1069-74.
2008: Ryan M B Hoffman; Brian D Sykes
Isoform-specific variation in the intrinsic disorder of troponin I.
Proteins 2008;73(2):338-50.
2008: Olga K Baryshnikova; Ian M Robertson; Pascal Mercier; Brian D Sykes
The dilated cardiomyopathy G159D mutation in cardiac troponin C weakens the anchoring interaction with troponin I.
Biochemistry 2008;47(41):10950-60.
2008: Ian M Robertson; Olga K Baryshnikova; Monica X Li; Brian D Sykes
Defining the binding site of levosimendan and its analogues in a regulatory cardiac troponin C-troponin I complex.
Biochemistry 2008;47(28):7485-95.
2008: Olga K Baryshnikova; Thomas C Williams; Brian D Sykes
Internal pH indicators for biomolecular NMR.
Journal of biomolecular NMR 2008;41(1):5-7.
2008: Monica X Li; Ian M Robertson; Brian D Sykes
Interaction of cardiac troponin with cardiotonic drugs: a structural perspective.
Biochemical and biophysical research communications 2008;369(1):88-99.
2008: Olivier Julien; Pascal Mercier; Leo Spyracopoulos; John E T Corrie; Brian D Sykes
NMR studies of the dynamics of a bifunctional rhodamine probe attached to troponin C.
Journal of the American Chemical Society 2008;130(8):2602-9.
2008: Olga K Baryshnikova; Monica X Li; Brian D Sykes
Modulation of cardiac troponin C function by the cardiac-specific N-terminus of troponin I: influence of PKA phosphorylation and involvement in cardiomyopathies.
Journal of molecular biology 2008;375(3):735-51.
2008: Olivier Julien; Yin-Biao Sun; Xu Wang; Darrin A Lindhout; Angela Thiessen; Malcolm Irving; Brian D Sykes
Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity.
Biochemistry 2008;47(2):597-606.
2007: Carolyn Slupsky; Kathryn N Rankin; James Wagner; Hao Fu; David Chang; Aalim M Weljie; Erik J Saude; Bruce Lix; Darryl J Adamko; Sirish Shah; Russell Greiner; Brian D Sykes; Thomas J Marrie
Investigations of the effects of gender, diurnal variation, and age in human urinary metabolomic profiles.
Analytical chemistry 2007;79(18):6995-7004.
2007: Samuel S W Szeto; Stacey N Reinke; Brian D Sykes; Bernard D Lemire
Ubiquinone-binding site mutations in the Saccharomyces cerevisiae succinate dehydrogenase generate superoxide and lead to the accumulation of succinate.
The Journal of biological chemistry 2007;282(37):27518-26.
2007: Olivier Julien; Yin-Biao Sun; Andrea C Knowles; Birgit D Brandmeier; Robert E Dale; David R Trentham; John E T Corrie; Brian D Sykes; Malcolm Irving
Toward protein structure in situ: comparison of two bifunctional rhodamine adducts of troponin C.
Biophysical journal 2007;93(3):1008-20.
2007: Xingang Zhao; Jeffrey S DeVries; Robert McDonald; Brian D Sykes
Determination of the 19F NMR chemical shielding tensor and crystal structure of 5-fluoro-dl-tryptophan.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2007;187(1):88-96.
2007: Jan K Rainey; Jeffrey S DeVries; Brian D Sykes
Estimation and measurement of flat or solenoidal coil inductance for radiofrequency NMR coil design.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2007;187(1):27-37.
2007: Carolyn Slupsky; Leo Spyracopoulos; Valerie Booth; Brian D Sykes; Matthew Crump
Probing nascent structures in peptides using natural abundance 13C NMR relaxation and reduced spectral density mapping.
Proteins 2007;67(1):18-30.
2007: Emily R Slepkov; Jan K Rainey; Brian D Sykes; Larry Fliegel
Structural and functional analysis of the Na+/H+ exchanger.
The Biochemical journal 2007;401(3):623-33.
2007: Andrew J Scotter; Meng Guo; Melanie Tomczak; Margaret E Daley; Robert L Campbell; Richard J Oko; David A Bateman; Avijit Chakrabartty; Brian D Sykes; Peter L Davies
Metal ion-dependent, reversible, protein filament formation by designed beta-roll polypeptides.
BMC structural biology 2007;7():63.
2007: Ryan M B Hoffman; Brian D Sykes
Disposition and dynamics: interdomain orientations in troponin.
Advances in experimental medicine and biology 2007;592():59-70.
2006: Jan K Rainey; Larry Fliegel; Brian D Sykes
Strategies for dealing with conformational sampling in structural calculations of flexible or kinked transmembrane peptides.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2006;84(6):918-29.
2006: Olga K Baryshnikova; Brian D Sykes
Backbone dynamics of SDF-1alpha determined by NMR: interpretation in the presence of monomer-dimer equilibrium.
Protein science : a publication of the Protein Society 2006;15(11):2568-78.
2006: Jie Ding; Jan K Rainey; Caroline Xu; Brian D Sykes; Larry Fliegel
Structural and functional characterization of transmembrane segment VII of the Na+/H+ exchanger isoform 1.
The Journal of biological chemistry 2006;281(40):29817-29.
2006: Ryan M B Hoffman; Tharin M A Blumenschein; Brian D Sykes
An interplay between protein disorder and structure confers the Ca2+ regulation of striated muscle.
Journal of molecular biology 2006;361(4):625-33.
2006: Monica X Li; Ryan M B Hoffman; Brian D Sykes
Interaction of cardiac troponin C with calmodulin antagonist [corrected] W7 in the presence of three functional regions of cardiac troponin I.
Biochemistry 2006;45(32):9833-40.
2006: Steffen P Graether; Carolyn Slupsky; Brian D Sykes
Effect of a mutation on the structure and dynamics of an alpha-helical antifreeze protein in water and ice.
Proteins 2006;63(3):603-10.
2006: Tharin M A Blumenschein; Deborah B Stone; Robert J Fletterick; Robert A Mendelson; Brian D Sykes
Dynamics of the C-terminal region of TnI in the troponin complex in solution.
Biophysical journal 2006;90(7):2436-44.
2006: Steffen P Graether; Jeffrey S DeVries; Robert McDonald; Melissa L Rakovszky; Brian D Sykes
A 1H/19F minicoil NMR probe for solid-state NMR: application to 5-fluoroindoles.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2006;178(1):65-71.
2005: Ryan M B Hoffman; Monica X Li; Brian D Sykes
The binding of W7, an inhibitor of striated muscle contraction, to cardiac troponin C.
Biochemistry 2005;44(48):15750-9.
2005: Olga K Baryshnikova; Jan K Rainey; Brian D Sykes
Nuclear magnetic resonance studies of CXC chemokine receptor 4 allosteric peptide agonists in solution.
The journal of peptide research : official journal of the American Peptide Society 2005;66 Suppl 1():12-21.
2005: Darrin A Lindhout; Robert F Boyko; David C Corson; Monica X Li; Brian D Sykes
The role of electrostatics in the interaction of the inhibitory region of troponin I with troponin C.
Biochemistry 2005;44(45):14750-9.
2005: Jan K Rainey; Brian D Sykes
Optimizing oriented planar-supported lipid samples for solid-state protein NMR.
Biophysical journal 2005;89(4):2792-805.
2005: Xu Wang; Pascal Mercier; Paul-Jean Letourneau; Brian D Sykes
Effects of Phe-to-Trp mutation and fluorotryptophan incorporation on the solution structure of cardiac troponin C, and analysis of its suitability as a potential probe for in situ NMR studies.
Protein science : a publication of the Protein Society 2005;14(9):2447-60.
2005: Tharin M A Blumenschein; Deborah B Stone; Robert J Fletterick; Robert A Mendelson; Brian D Sykes
Calcium-dependent changes in the flexibility of the regulatory domain of troponin C in the troponin complex.
The Journal of biological chemistry 2005;280(23):21924-32.
2005: Emily R Slepkov; Jan K Rainey; Xiuju Li; Yongsheng Liu; Florence J Cheng; Darrin A Lindhout; Brian D Sykes; Larry Fliegel
Structural and functional characterization of transmembrane segment IV of the NHE1 isoform of the Na+/H+ exchanger.
The Journal of biological chemistry 2005;280(18):17863-72.
2005: Erin J van Schaik; Carmen L Giltner; Gerald F Audette; David Keizer; Daisy L Bautista; Carolyn Slupsky; Brian D Sykes; Randall T Irvin
DNA binding: a novel function of Pseudomonas aeruginosa type IV pili.
Journal of bacteriology 2005;187(4):1455-64.
2004: Darrin A Lindhout; Jennifer R Litowski; Pascal Mercier; Robert S Hodges; Brian D Sykes
NMR solution structure of a highly stable de novo heterodimeric coiled-coil.
Biopolymers 2004;75(5):367-75.
2004: Margaret E Daley; Steffen P Graether; Brian D Sykes
Hydrogen bonding on the ice-binding face of a beta-helical antifreeze protein indicated by amide proton NMR chemical shifts.
Biochemistry 2004;43(41):13012-7.
2004: Erik J Saude; Paige Lacy; Sorin Musat-Marcu; Damon C Mayes; John Bagu; S F Paul Man; Brian D Sykes; Redwan Moqbel
NMR analysis of neutrophil activation in sputum samples from patients with cystic fibrosis.
Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine 2004;52(4):807-14.
2004: Christopher B Marshall; Margaret E Daley; Brian D Sykes; Peter L Davies
Enhancing the activity of a beta-helical antifreeze protein by the engineered addition of coils.
Biochemistry 2004;43(37):11637-46.
2004: Steffen P Graether; Brian D Sykes
Cold survival in freeze-intolerant insects: the structure and function of beta-helical antifreeze proteins.
European journal of biochemistry / FEBS 2004;271(16):3285-96.
2004: Valerie Booth; Ian Clark-Lewis; Brian D Sykes
NMR structure of CXCR3 binding chemokine CXCL11 (ITAC).
Protein science : a publication of the Protein Society 2004;13(8):2022-8.
2004: Margaret E Daley; Brian D Sykes
Characterization of threonine side chain dynamics in an antifreeze protein using natural abundance 13C NMR spectroscopy.
Journal of biomolecular NMR 2004;29(2):139-50.
2004: Tharin M A Blumenschein; Todd E Gillis; Glen F Tibbits; Brian D Sykes
Effect of temperature on the structure of trout troponin C.
Biochemistry 2004;43(17):4955-63.
2004: Grant L Gay; Darrin A Lindhout; Brian D Sykes
Using lanthanide ions to align troponin complexes in solution: order of lanthanide occupancy in cardiac troponin C.
Protein science : a publication of the Protein Society 2004;13(3):640-51.
2004: Monica X Li; Xu Wang; Brian D Sykes
Structural based insights into the role of troponin in cardiac muscle pathophysiology.
Journal of muscle research and cell motility 2004;25(7):559-79.
2003: Monica X Li; Xu Wang; Darrin A Lindhout; Nina Buscemi; Jennifer E Van Eyk; Brian D Sykes
Phosphorylation and mutation of human cardiac troponin I deferentially destabilize the interaction of the functional regions of troponin I with troponin C.
Biochemistry 2003;42(49):14460-8.
2003: Carolyn Slupsky; Robert F Boyko; Valerie Booth; Brian D Sykes
Smartnotebook: a semi-automated approach to protein sequential NMR resonance assignments.
Journal of biomolecular NMR 2003;27(4):313-21.
2003: A Patricia Campbell; Leo Spyracopoulos; Wah Y Wong; Randall T Irvin; Brian D Sykes
Interaction of a peptide from the receptor-binding domain of Pseudomonas aeruginosa pili strain PAK with a cross-reactive antibody: changes in backbone dynamics induced by binding.
Biochemistry 2003;42(38):11334-46.
2003: Darrin A Lindhout; Angela Thiessen; Dean Schieve; Brian D Sykes
High-yield expression of isotopically labeled peptides for use in NMR studies.
Protein science : a publication of the Protein Society 2003;12(8):1786-91.
2003: Darrin A Lindhout; Brian D Sykes
Structure and dynamics of the C-domain of human cardiac troponin C in complex with the inhibitory region of human cardiac troponin I.
The Journal of biological chemistry 2003;278(29):27024-34.
2003: Vincent Raussens; Carolyn Slupsky; Brian D Sykes; Robert O Ryan
Lipid-bound structure of an apolipoprotein E-derived peptide.
The Journal of biological chemistry 2003;278(28):25998-6006.
2003: Margaret E Daley; Brian D Sykes
The role of side chain conformational flexibility in surface recognition by Tenebrio molitor antifreeze protein.
Protein science : a publication of the Protein Society 2003;12(7):1323-31.
2003: Leigh Willard; Anuj Ranjan; Haiyan Zhang; Hassan Monzavi; Robert F Boyko; Brian D Sykes; David S Wishart
VADAR: a web server for quantitative evaluation of protein structure quality.
Nucleic acids research 2003;31(13):3316-9.
2003: Todd E Gillis; Tharin M A Blumenschein; Brian D Sykes; Glen F Tibbits
Effect of temperature and the F27W mutation on the Ca2+ activated structural transition of trout cardiac troponin C.
Biochemistry 2003;42(21):6418-26.
2003: Pascal Mercier; Roisean E Ferguson; Malcolm Irving; John E T Corrie; David R Trentham; Brian D Sykes
NMR structure of a bifunctional rhodamine labeled N-domain of troponin C complexed with the regulatory "switch" peptide from troponin I: implications for in situ fluorescence studies in muscle fibers.
Biochemistry 2003;42(15):4333-48.
2003: Steffen P Graether; Stéphane M Gagné; Leo Spyracopoulos; Zongchao Jia; Peter L Davies; Brian D Sykes
Spruce budworm antifreeze protein: changes in structure and dynamics at low temperature.
Journal of molecular biology 2003;327(5):1155-68.
2003: Roisean E Ferguson; Yin-Biao Sun; Pascal Mercier; Andrew S Brack; Brian D Sykes; John E T Corrie; David R Trentham; Malcolm Irving
In situ orientations of protein domains: troponin C in skeletal muscle fibers.
Molecular cell 2003;11(4):865-74.
2003: Paul-Jean Letourneau; Robert F Boyko; Brian D Sykes
PJNMR: a platform-independent graphical simulation tool for NMR spectroscopy.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2003;161(2):154-67.
2003: Valerie Booth; Carolyn Slupsky; Ian Clark-Lewis; Brian D Sykes
Unmasking ligand binding motifs: identification of a chemokine receptor motif by NMR studies of antagonist peptides.
Journal of molecular biology 2003;327(2):329-34.
2003: Jonathan R T Lakey; Lisa M H Helms; Gabrielle Moser; Bruce Lix; Carolyn Slupsky; Ivan M Rebeyka; Brian D Sykes; Locksley E McGann
Dynamics of cryoprotectant permeation in porcine heart valve leaflets.
Cell transplantation 2003;12(2):123-8.
2003: Steffen P Graether; Carolyn Slupsky; Brian D Sykes
Freezing of a fish antifreeze protein results in amyloid fibril formation.
Biophysical journal 2003;84(1):552-7.
2002: Christopher B Marshall; Margaret E Daley; Laurie A Graham; Brian D Sykes; Peter L Davies
Identification of the ice-binding face of antifreeze protein from Tenebrio molitor.
FEBS letters 2002;529(2-3):261-7.
2002: Xu Wang; Monica X Li; Brian D Sykes
Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil.
The Journal of biological chemistry 2002;277(34):31124-33.
2002: Valerie Booth; David Keizer; Monique B Kamphuis; Ian Clark-Lewis; Brian D Sykes
The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions.
Biochemistry 2002;41(33):10418-25.
2002: Vincent Raussens; Carolyn Slupsky; Robert O Ryan; Brian D Sykes
NMR structure and dynamics of a receptor-active apolipoprotein E peptide.
The Journal of biological chemistry 2002;277(32):29172-80.
2002: Monica X Li; Erik J Saude; Xu Wang; Joyce R Pearlstone; Lawrence B Smillie; Brian D Sykes
Kinetic studies of calcium and cardiac troponin I peptide binding to human cardiac troponin C using NMR spectroscopy.
European biophysics journal : EBJ 2002;31(4):245-56.
2002: Darrin A Lindhout; Monica X Li; Dean Schieve; Brian D Sykes
Effects of T142 phosphorylation and mutation R145G on the interaction of the inhibitory region of human cardiac troponin I with the C-domain of human cardiac troponin C.
Biochemistry 2002;41(23):7267-74.
2002: Margaret E Daley; Leo Spyracopoulos; Zongchao Jia; Peter L Davies; Brian D Sykes
Structure and dynamics of a beta-helical antifreeze protein.
Biochemistry 2002;41(17):5515-25.
2002: Monica X Li; David C Corson; Brian D Sykes
Structure determination by NMR. Isotope labeling.
Methods in molecular biology (Clifton, N.J.) 2002;173():255-65.
2001: Leo Spyracopoulos; P Lavigne; Matthew Crump; Stéphane M Gagné; Cyril M Kay; Brian D Sykes
Temperature dependence of dynamics and thermodynamics of the regulatory domain of human cardiac troponin C.
Biochemistry 2001;40(42):12541-51.
2001: Leo Spyracopoulos; Brian D Sykes
Thermodynamic insights into proteins from NMR spin relaxation studies.
Current opinion in structural biology 2001;11(5):555-9.
2001: Tharin M A Blumenschein; Brian Tripet; Robert S Hodges; Brian D Sykes
Mapping the interacting regions between troponins T and C. Binding of TnT and TnI peptides to TnC and NMR mapping of the TnT-binding site on TnC.
The Journal of biological chemistry 2001;276(39):36606-12.
2001: Steffen P Graether; Carolyn Slupsky; Peter L Davies; Brian D Sykes
Structure of type I antifreeze protein and mutants in supercooled water.
Biophysical journal 2001;81(3):1677-83.
2001: Pascal Mercier; Leo Spyracopoulos; Brian D Sykes
Structure, dynamics, and thermodynamics of the structural domain of troponin C in complex with the regulatory peptide 1-40 of troponin I.
Biochemistry 2001;40(34):10063-77.
2001: Xu Wang; Monica X Li; Leo Spyracopoulos; N Beier; Murali Chandra; R John Solaro; Brian D Sykes
Structure of the C-domain of human cardiac troponin C in complex with the Ca2+ sensitizing drug EMD 57033.
The Journal of biological chemistry 2001;276(27):25456-66.
2001: David Keizer; Carolyn Slupsky; Michal S Kalisiak; A Patricia Campbell; Matthew Crump; P A Sastry; Bart Hazes; Randall T Irvin; Brian D Sykes
Structure of a pilin monomer from Pseudomonas aeruginosa: implications for the assembly of pili.
The Journal of biological chemistry 2001;276(26):24186-93.
2001: Carolyn Slupsky; D B Sykes; G L Gay; Brian D Sykes
The HoxB1 hexapeptide is a prefolded domain: implications for the Pbx1/Hox interaction.
Protein science : a publication of the Protein Society 2001;10(6):1244-53.
2001: J Y Suh; Leo Spyracopoulos; David Keizer; Randall T Irvin; Brian D Sykes
Backbone dynamics of receptor binding and antigenic regions of a Pseudomonas aeruginosa pilin monomer.
Biochemistry 2001;40(13):3985-95.
2001: David Keizer; Michal S Kalisiak; Matthew Crump; J Y Suh; Randall T Irvin; Brian D Sykes
Assignments of 1H and 15N resonances of the Pseudomonas aeruginosa K122-4 pilin monomer.
Journal of biomolecular NMR 2001;19(4):385-6.
2001: Matthew Crump; EL Elisseeva; J Gong; Ian Clark-Lewis; Brian D Sykes
Structure/function of human herpesvirus-8 MIP-II (1-71) and the antagonist N-terminal segment (1-10).
FEBS letters 2001;489(2-3):171-5.
2000: Vincent Raussens; M K Mah; Cyril M Kay; Brian D Sykes; Robert O Ryan
Structural characterization of a low density lipoprotein receptor-active apolipoprotein E peptide, ApoE3-(126-183).
The Journal of biological chemistry 2000;275(49):38329-36.
2000: A Patricia Campbell; Wah Y Wong; Randall T Irvin; Brian D Sykes
Interaction of a bacterially expressed peptide from the receptor binding domain of Pseudomonas aeruginosa pili strain PAK with a cross-reactive antibody: conformation of the bound peptide.
Biochemistry 2000;39(48):14847-64.
2000: Ryan T McKay; Linda F Saltibus; Monica X Li; Brian D Sykes
Energetics of the induced structural change in a Ca2+ regulatory protein: Ca2+ and troponin I peptide binding to the E41A mutant of the N-domain of skeletal troponin C.
Biochemistry 2000;39(41):12731-8.
2000: Daniel Doucet; Michael G Tyshenko; Michael Kuiper; Steffen P Graether; Brian D Sykes; Andrew J Daugulis; Peter L Davies; Virginia K Walker
Structure-function relationships in spruce budworm antifreeze protein revealed by isoform diversity.
European journal of biochemistry / FEBS 2000;267(19):6082-8.
2000: EL Elisseeva; Carolyn Slupsky; Matthew Crump; Ian Clark-Lewis; Brian D Sykes
NMR studies of active N-terminal peptides of stromal cell-derived factor-1. Structural basis for receptor binding.
The Journal of biological chemistry 2000;275(35):26799-805.
2000: Monica X Li; Leo Spyracopoulos; N Beier; J A Putkey; Brian D Sykes
Interaction of cardiac troponin C with Ca(2+) sensitizer EMD 57033 and cardiac troponin I inhibitory peptide.
Biochemistry 2000;39(30):8782-90.
2000: Steffen P Graether; Michael Kuiper; Stéphane M Gagné; Virginia K Walker; Zongchao Jia; Brian D Sykes; Peter L Davies
Beta-helix structure and ice-binding properties of a hyperactive antifreeze protein from an insect.
Nature 2000;406(6793):325-8.
2000: A Patricia Campbell; Leo Spyracopoulos; Randall T Irvin; Brian D Sykes
Backbone dynamics of a bacterially expressed peptide from the receptor binding domain of Pseudomonas aeruginosa pilin strain PAK from heteronuclear 1H-15N NMR spectroscopy.
Journal of biomolecular NMR 2000;17(3):239-55.
2000: YC Liou; Margaret E Daley; Laurie A Graham; Cyril M Kay; Virginia K Walker; Brian D Sykes; Peter L Davies
Folding and structural characterization of highly disulfide-bonded beetle antifreeze protein produced in bacteria.
Protein expression and purification 2000;19(1):148-57.
2000: David Keizer; Matthew Crump; T W Lee; Carolyn Slupsky; Ian Clark-Lewis; Brian D Sykes
Human CC chemokine I-309, structural consequences of the additional disulfide bond.
Biochemistry 2000;39(20):6053-9.
2000: C McInnes; Leslie H Kondejewski; Robert S Hodges; Brian D Sykes
Development of the structural basis for antimicrobial and hemolytic activities of peptides based on gramicidin S and design of novel analogs using NMR spectroscopy.
The Journal of biological chemistry 2000;275(19):14287-94.
2000: Pascal Mercier; Monica X Li; Brian D Sykes
Role of the structural domain of troponin C in muscle regulation: NMR studies of Ca2+ binding and subsequent interactions with regions 1-40 and 96-115 of troponin I.
Biochemistry 2000;39(11):2902-11.
2000: C McInnes; Suzanne Grothe; Maureen D O'Connor-McCourt; Brian D Sykes
NMR study of the differential contributions of residues of transforming growth factor alpha to association with its receptor.
Protein engineering 2000;13(3):143-7.
2000: P Lavigne; John Bagu; Robert F Boyko; Leigh Willard; Charles F B Holmes; Brian D Sykes
Structure-based thermodynamic analysis of the dissociation of protein phosphatase-1 catalytic subunit and microcystin-LR docked complexes.
Protein science : a publication of the Protein Society 2000;9(2):252-64.
1999: Matthew Crump; Leo Spyracopoulos; P Lavigne; K S Kim; Ian Clark-Lewis; Brian D Sykes
Backbone dynamics of the human CC chemokine eotaxin: fast motions, slow motions, and implications for receptor binding.
Protein science : a publication of the Protein Society 1999;8(10):2041-54.
1999: Monica X Li; Leo Spyracopoulos; Brian D Sykes
Binding of cardiac troponin-I147-163 induces a structural opening in human cardiac troponin-C.
Biochemistry 1999;38(26):8289-98.
1999: Krishna Rajarathnam; Brian D Sykes; B Dewald; Marco Baggiolini; Ian Clark-Lewis
Disulfide bridges in interleukin-8 probed using non-natural disulfide analogues: dissociation of roles in structure from function.
Biochemistry 1999;38(24):7653-8.
1999: Leslie H Kondejewski; Masood Jelokhani-Niaraki; Susan W Farmer; Bruce Lix; Cyril M Kay; Brian D Sykes; Robert E W Hancock; Robert S Hodges
Dissociation of antimicrobial and hemolytic activities in cyclic peptide diastereomers by systematic alterations in amphipathicity.
The Journal of biological chemistry 1999;274(19):13181-92.
1999: S Tsuda; A Miura; Stéphane M Gagné; Leo Spyracopoulos; Brian D Sykes
Low-temperature-induced structural changes in the Apo regulatory domain of skeletal muscle troponin C.
Biochemistry 1999;38(18):5693-700.
1999: Ryan T McKay; Brian Tripet; Joyce R Pearlstone; Lawrence B Smillie; Brian D Sykes
Defining the region of troponin-I that binds to troponin-C.
Biochemistry 1999;38(17):5478-89.
1999: MC Loewen; H Chao; ME Houston; Jason Baardsnes; Robert S Hodges; Cyril M Kay; Brian D Sykes; FD Sönnichsen; Peter L Davies
Alternative roles for putative ice-binding residues in type I antifreeze protein.
Biochemistry 1999;38(15):4743-9.
1999: Krishna Rajarathnam; Matthew Crump; Ian Clark-Lewis; Brian D Sykes
Spectroscopic characterization of chemokines: relevance for quality control and standardization.
Developments in biological standardization 1999;97():49-57.
1998: Leo Spyracopoulos; Stéphane M Gagné; Monica X Li; Brian D Sykes
Dynamics and thermodynamics of the regulatory domain of human cardiac troponin C in the apo- and calcium-saturated states.
Biochemistry 1998;37(51):18032-44.
1998: MC Loewen; W Gronwald; FD Sönnichsen; Brian D Sykes; Peter L Davies
The ice-binding site of sea raven antifreeze protein is distinct from the carbohydrate-binding site of the homologous C-type lectin.
Biochemistry 1998;37(51):17745-53.
1998: Sherry Y Gauthier; Cyril M Kay; Brian D Sykes; Virginia K Walker; Peter L Davies
Disulfide bond mapping and structural characterization of spruce budworm antifreeze protein.
European journal of biochemistry / FEBS 1998;258(2):445-53.
1998: C McInnes; J Wang; Ala-Eddin Al Moustafa; C Yansouni; Maureen D O'Connor-McCourt; Brian D Sykes
Structure-based minimization of transforming growth factor-alpha (TGF-alpha) through NMR analysis of the receptor-bound ligand. Design, solution structure, and activity of TGF-alpha 8-50.
The Journal of biological chemistry 1998;273(42):27357-63.
1998: W Gronwald; Leigh Willard; T Jellard; Robert F Boyko; Krishna Rajarathnam; David S Wishart; FD Sönnichsen; Brian D Sykes
CAMRA: chemical shift based computer aided protein NMR assignments.
Journal of biomolecular NMR 1998;12(3):395-405.
1998: Ryan T McKay; Joyce R Pearlstone; David C Corson; Stéphane M Gagné; Lawrence B Smillie; Brian D Sykes
Structure and interaction site of the regulatory domain of troponin-C when complexed with the 96-148 region of troponin-I.
Biochemistry 1998;37(36):12419-30.
1998: Matthew Crump; Krishna Rajarathnam; K S Kim; Ian Clark-Lewis; Brian D Sykes
Solution structure of eotaxin, a chemokine that selectively recruits eosinophils in allergic inflammation.
The Journal of biological chemistry 1998;273(35):22471-9.
1998: P Lavigne; Matthew Crump; Stéphane M Gagné; Robert S Hodges; Cyril M Kay; Brian D Sykes
Insights into the mechanism of heterodimerization from the 1H-NMR solution structure of the c-Myc-Max heterodimeric leucine zipper.
Journal of molecular biology 1998;281(1):165-81.
1998: Paul M M Weers; J Wang; DJ Van der Horst; Cyril M Kay; Brian D Sykes; Robert O Ryan
Recombinant locust apolipophorin III: characterization and NMR spectroscopy.
Biochimica et biophysica acta 1998;1393(1):99-107.
1998: Stéphane M Gagné; S Tsuda; Leo Spyracopoulos; L E Kay; Brian D Sykes
Backbone and methyl dynamics of the regulatory domain of troponin C: anisotropic rotational diffusion and contribution of conformational entropy to calcium affinity.
Journal of molecular biology 1998;278(3):667-86.
1998: ME Houston; H Chao; Robert S Hodges; Brian D Sykes; Cyril M Kay; FD Sönnichsen; MC Loewen; Peter L Davies
Binding of an oligopeptide to a specific plane of ice.
The Journal of biological chemistry 1998;273(19):11714-8.
1998: W Gronwald; MC Loewen; Bruce Lix; Andrew J Daugulis; FD Sönnichsen; Peter L Davies; Brian D Sykes
The solution structure of type II antifreeze protein reveals a new member of the lectin family.
Biochemistry 1998;37(14):4712-21.
1998: Alan C Gibbs; Leslie H Kondejewski; W Gronwald; Alex M Nip; Robert S Hodges; Brian D Sykes; David S Wishart
Unusual beta-sheet periodicity in small cyclic peptides.
Nature structural biology 1998;5(4):284-8.
1998: J Wang; Vasanthy Narayanaswami; Brian D Sykes; Robert O Ryan
Interhelical contacts are required for the helix bundle fold of apolipophorin III and its ability to interact with lipoproteins.
Protein science : a publication of the Protein Society 1998;7(2):336-41.
1998: Stéphane M Gagné; Monica X Li; Ryan T McKay; Brian D Sykes
The NMR angle on troponin C.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1998;76(2-3):302-12.
1998: J Wang; Daisy Sahoo; Brian D Sykes; Robert O Ryan
NMR evidence for a conformational adaptation of apolipophorin III upon lipid association.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1998;76(2-3):276-83.
1997: H Chao; ME Houston; Robert S Hodges; Cyril M Kay; Brian D Sykes; MC Loewen; Peter L Davies; FD Sönnichsen
A diminished role for hydrogen bonds in antifreeze protein binding to ice.
Biochemistry 1997;36(48):14652-60.
1997: David S Wishart; M S Watson; Robert F Boyko; Brian D Sykes
Automated 1H and 13C chemical shift prediction using the BioMagResBank.
Journal of biomolecular NMR 1997;10(4):329-36.
1997: Matthew Crump; Jiang-Hong Gong; Pius Loetscher; Krishna Rajarathnam; Ali Amara; Fernando Arenzana-Seisdedos; Jean-Louis Virelizier; Marco Baggiolini; Brian D Sykes; Ian Clark-Lewis
Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1.
The EMBO journal 1997;16(23):6996-7007.
1997: Ryan T McKay; Brian Tripet; Robert S Hodges; Brian D Sykes
Interaction of the second binding region of troponin I with the regulatory domain of skeletal muscle troponin C as determined by NMR spectroscopy.
The Journal of biological chemistry 1997;272(45):28494-500.
1997: A Patricia Campbell; Daisy L Bautista; Brian Tripet; Wah Y Wong; Randall T Irvin; Robert S Hodges; Brian D Sykes
Solution secondary structure of a bacterially expressed peptide from the receptor binding domain of Pseudomonas aeruginosa pili strain PAK: A heteronuclear multidimensional NMR study.
Biochemistry 1997;36(42):12791-801.
1997: Monica X Li; Stéphane M Gagné; Leo Spyracopoulos; C P Kloks; Gerald F Audette; Murali Chandra; R John Solaro; Lawrence B Smillie; Brian D Sykes
NMR studies of Ca2+ binding to the regulatory domains of cardiac and E41A skeletal muscle troponin C reveal the importance of site I to energetics of the induced structural changes.
Biochemistry 1997;36(41):12519-25.
1997: Leo Spyracopoulos; Monica X Li; SK Sia; Stéphane M Gagné; Murali Chandra; R John Solaro; Brian D Sykes
Calcium-induced structural transition in the regulatory domain of human cardiac troponin C.
Biochemistry 1997;36(40):12138-46.
1997: XB Tang; P Dallaire; D W Hoyt; Brian D Sykes; Maureen D O'Connor-McCourt; BA Malcolm
Construction of transforming growth factor alpha (TGF-alpha) phage library and identification of high binders of epidermal growth factor receptor (EGFR) by phage display.
Journal of biochemistry 1997;122(4):686-90.
1997: W Gronwald; Robert F Boyko; Brian D Sykes
GSC: a graphical program for NMR chemical shift comparison.
Computer applications in the biosciences : CABIOS 1997;13(5):557-8.
1997: SK Sia; Monica X Li; Leo Spyracopoulos; Stéphane M Gagné; W Liu; J A Putkey; Brian D Sykes
Structure of cardiac muscle troponin C unexpectedly reveals a closed regulatory domain.
The Journal of biological chemistry 1997;272(29):18216-21.
1997: J Wang; Stéphane M Gagné; Brian D Sykes; Robert O Ryan
Insight into lipid surface recognition and reversible conformational adaptations of an exchangeable apolipoprotein by multidimensional heteronuclear NMR techniques.
The Journal of biological chemistry 1997;272(29):17912-20.
1997: Joyce R Pearlstone; Brian D Sykes; Lawrence B Smillie
Interactions of structural C and regulatory N domains of troponin C with repeated sequence motifs in troponin I.
Biochemistry 1997;36(24):7601-6.
1997: Stéphane M Gagné; Monica X Li; Brian D Sykes
Mechanism of direct coupling between binding and induced structural change in regulatory calcium binding proteins.
Biochemistry 1997;36(15):4386-92.
1997: A Patricia Campbell; Wah Y Wong; M Houston; Frank Schweizer; PJ Cachia; Randall T Irvin; Ole Hindsgaul; Robert S Hodges; Brian D Sykes
Interaction of the receptor binding domains of Pseudomonas aeruginosa pili strains PAK, PAO, KB7 and P1 to a cross-reactive antibody and receptor analog: implications for synthetic vaccine design.
Journal of molecular biology 1997;267(2):382-402.
1997: John Bagu; Brian D Sykes; M M Craig; Charles F B Holmes
A molecular basis for different interactions of marine toxins with protein phosphatase-1. Molecular models for bound motuporin, microcystins, okadaic acid, and calyculin A.
The Journal of biological chemistry 1997;272(8):5087-97.
1997: Krishna Rajarathnam; Cyril M Kay; B Dewald; Marlene Wolf; Marco Baggiolini; Ian Clark-Lewis; Brian D Sykes
Neutrophil-activating peptide-2 and melanoma growth-stimulatory activity are functional as monomers for neutrophil activation.
The Journal of biological chemistry 1997;272(3):1725-9.
1997: Campbell McInnes; Brian D Sykes
Growth factor receptors: structure, mechanism, and drug discovery.
Biopolymers 1997;43(5):339-66.
1997: Krishna Rajarathnam; Cyril M Kay; Ian Clark-Lewis; Brian D Sykes
Characterization of quaternary structure of interleukin-8 and functional implications.
Methods in enzymology 1997;287():89-105.
1997: CA Fisher; J Wang; Gordon A Francis; Brian D Sykes; Cyril M Kay; Robert O Ryan
Bacterial overexpression, isotope enrichment, and NMR analysis of the N-terminal domain of human apolipoprotein E.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1997;75(1):45-53.
1996: W Gronwald; H Chao; D Venkat Reddy; Peter L Davies; Brian D Sykes; F D Sönnichsen
NMR characterization of side chain flexibility and backbone structure in the type I antifreeze protein at near freezing temperatures.
Biochemistry 1996;35(51):16698-704.
1996: Campbell McInnes; D W Hoyt; R N Harkins; R N Pagila; M T Debanne; Maureen D O'Connor-McCourt; Brian D Sykes
NMR study of the transforming growth factor-alpha (TGF-alpha)-epidermal growth factor receptor complex. Visualization of human TGF-alpha binding determinants through nuclear Overhauser enhancement analysis.
The Journal of biological chemistry 1996;271(50):32204-11.
1996: Krishna Rajarathnam; Ian Clark-Lewis; B Dewald; Marco Baggiolini; Brian D Sykes
1H NMR evidence that Glu-38 interacts with the N-terminal functional domain in interleukin-8.
FEBS letters 1996;399(1-2):43-6.
1996: J Wang; E Breslow; Brian D Sykes
Differential binding of desmopressin and vasopressin to neurophysin-II.
The Journal of biological chemistry 1996;271(49):31354-9.
1996: A Patricia Campbell; H Sheth; Robert S Hodges; Brian D Sykes
NMR solution structure of the receptor binding domain of Pseudomonas aeruginosa pilin strain P1. Identification of a beta-turn.
International journal of peptide and protein research 1996;48(6):539-52.
1996: F D Sönnichsen; C I DeLuca; Peter L Davies; Brian D Sykes
Refined solution structure of type III antifreeze protein: hydrophobic groups may be involved in the energetics of the protein-ice interaction.
Structure (London, England : 1993) 1996;4(11):1325-37.
1996: C I DeLuca; H Chao; F D Sönnichsen; Brian D Sykes; Peter L Davies
Effect of type III antifreeze protein dilution and mutation on the growth inhibition of ice.
Biophysical journal 1996;71(5):2346-55.
1996: K S Kim; Krishna Rajarathnam; Ian Clark-Lewis; Brian D Sykes
Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3.
FEBS letters 1996;395(2-3):277-82.
1996: M E Houston; A Patricia Campbell; Bruce Lix; Cyril M Kay; Brian D Sykes; Robert S Hodges
Lactam bridge stabilization of alpha-helices: the role of hydrophobicity in controlling dimeric versus monomeric alpha-helices.
Biochemistry 1996;35(31):10041-50.
1996: Brian D Sykes
Application of NMR spectroscopy to muscle calcium-binding proteins.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.] 1996;29(7):825-9.
1995: A Patricia Campbell; Campbell McInnes; Robert S Hodges; Brian D Sykes
Comparison of NMR solution structures of the receptor binding domains of Pseudomonas aeruginosa pili strains PAO, KB7, and PAK: implications for receptor binding and synthetic vaccine design.
Biochemistry 1995;34(50):16255-68.
1995: Carolyn Slupsky; Brian D Sykes
NMR solution structure of calcium-saturated skeletal muscle troponin C.
Biochemistry 1995;34(49):15953-64.
1995: Krishna Rajarathnam; Ian Clark-Lewis; Brian D Sykes
1H NMR solution structure of an active monomeric interleukin-8.
Biochemistry 1995;34(40):12983-90.
1995: Wah Y Wong; A Patricia Campbell; Campbell McInnes; Brian D Sykes; W Paranchych; Randall T Irvin; Robert S Hodges
Structure-function analysis of the adherence-binding domain on the pilin of Pseudomonas aeruginosa strains PAK and KB7.
Biochemistry 1995;34(40):12963-72.
1995: David S Wishart; C G Bigam; J Yao; F Abildgaard; H J Dyson; E Oldfield; John Lute Markley; Brian D Sykes
1H, 13C and 15N chemical shift referencing in biomolecular NMR.
Journal of biomolecular NMR 1995;6(2):135-40.
1995: Stéphane M Gagné; S Tsuda; Monica X Li; Lawrence B Smillie; Brian D Sykes
Structures of the troponin C regulatory domains in the apo and calcium-saturated states.
Nature structural biology 1995;2(9):784-9.
1995: Monica X Li; Stéphane M Gagné; S Tsuda; Cyril M Kay; Lawrence B Smillie; Brian D Sykes
Calcium binding to the regulatory N-domain of skeletal muscle troponin C occurs in a stepwise manner.
Biochemistry 1995;34(26):8330-40.
1995: G D Henry; Brian D Sykes
Determination of the rotational dynamics and pH dependence of the hydrogen exchange rates of the arginine guanidino group using NMR spectroscopy.
Journal of biomolecular NMR 1995;6(1):59-66.
1995: Carolyn Slupsky; Fernando C Reinach; Lawrence B Smillie; Brian D Sykes
Solution secondary structure of calcium-saturated troponin C monomer determined by multidimensional heteronuclear NMR spectroscopy.
Protein science : a publication of the Protein Society 1995;4(7):1279-90.
1995: Carolyn Slupsky; Cyril M Kay; Fernando C Reinach; Lawrence B Smillie; Brian D Sykes
Calcium-induced dimerization of troponin C: mode of interaction and use of trifluoroethanol as a denaturant of quaternary structure.
Biochemistry 1995;34(22):7365-75.
1995: J Wang; H Liu; Brian D Sykes; Robert O Ryan
Identification and localization of two distinct microenvironments for the diacylglycerol component of lipophorin particles by 13C NMR.
Biochemistry 1995;34(20):6755-61.
1995: Ian Clark-Lewis; K S Kim; Krishna Rajarathnam; Jiang-Hong Gong; B Dewald; Bernhard Moser; Marco Baggiolini; Brian D Sykes
Structure-activity relationships of chemokines.
Journal of leukocyte biology 1995;57(5):703-11.
1995: J Wang; Robert S Hodges; Brian D Sykes
Effect of trifluoroethanol on the solution structure and flexibility of desmopressin: a two-dimensional NMR study.
International journal of peptide and protein research 1995;45(5):471-81.
1995: David S Wishart; C G Bigam; Robert S Hodges; A Holm; Brian D Sykes
(1)H, (13)C and (15)N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects.
Journal of biomolecular NMR 1995;5(3):332.
1995: F D Sönnichsen; Brian D Sykes; Peter L Davies
Comparative modeling of the three-dimensional structure of type II antifreeze protein.
Protein science : a publication of the Protein Society 1995;4(3):460-71.
1995: Yuanpeng Zhang; Ruthven N A H Lewis; G D Henry; Brian D Sykes; Robert S Hodges; Ronald N McElhaney
Peptide models of helical hydrophobic transmembrane segments of membrane proteins. 1. Studies of the conformation, intrabilayer orientation, and amide hydrogen exchangeability of Ac-K2-(LA)12-K2-amide.
Biochemistry 1995;34(7):2348-61.
1995: David S Wishart; C G Bigam; A Holm; Robert S Hodges; Brian D Sykes
1H, 13C and 15N random coil NMR chemical shifts of the common amino acids. I. Investigations of nearest-neighbor effects.
Journal of biomolecular NMR 1995;5(1):67-81.
1994: K S Kim; Ian Clark-Lewis; Brian D Sykes
Solution structure of GRO/melanoma growth stimulatory activity determined by 1H NMR spectroscopy.
The Journal of biological chemistry 1994;269(52):32909-15.
1994: D W Hoyt; R N Harkins; M T Debanne; Maureen D O'Connor-McCourt; Brian D Sykes
Interaction of transforming growth factor alpha with the epidermal growth factor receptor: binding kinetics and differential mobility within the bound TGF-alpha.
Biochemistry 1994;33(51):15283-92.
1994: David S Wishart; Robert F Boyko; Brian D Sykes
Constrained multiple sequence alignment using XALIGN.
Computer applications in the biosciences : CABIOS 1994;10(6):687-8.
1994: Stéphane M Gagné; S Tsuda; Monica X Li; Murali Chandra; Lawrence B Smillie; Brian D Sykes
Quantification of the calcium-induced secondary structural changes in the regulatory domain of troponin-C.
Protein science : a publication of the Protein Society 1994;3(11):1961-74.
1994: H Chao; F D Sönnichsen; C I DeLuca; Brian D Sykes; Peter L Davies
Structure-function relationship in the globular type III antifreeze protein: identification of a cluster of surface residues required for binding to ice.
Protein science : a publication of the Protein Society 1994;3(10):1760-9.
1994: Campbell McInnes; Cyril M Kay; Robert S Hodges; Brian D Sykes
Conformational differences between cis and trans proline isomers of a peptide antigen representing the receptor binding domain of Pseudomonas aeruginosa as studied by 1H-NMR.
Biopolymers 1994;34(9):1221-30.
1994: Gary Shaw; Robert S Hodges; Cyril M Kay; Brian D Sykes
Relative stabilities of synthetic peptide homo- and heterodimeric troponin-C domains.
Protein science : a publication of the Protein Society 1994;3(7):1010-9.
1994: Krishna Rajarathnam; Ian Clark-Lewis; Brian D Sykes
1H NMR studies of interleukin 8 analogs: characterization of the domains essential for function.
Biochemistry 1994;33(21):6623-30.
1994: Krishna Rajarathnam; Brian D Sykes; Cyril M Kay; B Dewald; T Geiser; Marco Baggiolini; Ian Clark-Lewis
Neutrophil activation by monomeric interleukin-8.
Science (New York, N.Y.) 1994;264(5155):90-2.
1994: David S Wishart; Robert F Boyko; L Willard; F M Richards; Brian D Sykes
SEQSEE: a comprehensive program suite for protein sequence analysis.
Computer applications in the biosciences : CABIOS 1994;10(2):121-32.
1994: W A Findlay; F D Sönnichsen; Brian D Sykes
Solution structure of the TR1C fragment of skeletal muscle troponin-C.
The Journal of biological chemistry 1994;269(9):6773-8.
1994: David S Wishart; Brian D Sykes
The 13C chemical-shift index: a simple method for the identification of protein secondary structure using 13C chemical-shift data.
Journal of biomolecular NMR 1994;4(2):171-80.
1994: James D Baleja; Brian D Sykes
A nuclear magnetic resonance study of the DNA-binding affinity of Cro repressor protein stabilized by a disulfide bond.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1994;72(3-4):95-108.
1994: G D Henry; Brian D Sykes
Methods to study membrane protein structure in solution.
Methods in enzymology 1994;239():515-35.
1994: David S Wishart; Brian D Sykes
Chemical shifts as a tool for structure determination.
Methods in enzymology 1994;239():363-92.
1993: Campbell McInnes; F D Sönnichsen; Cyril M Kay; Robert S Hodges; Brian D Sykes
NMR solution structure and flexibility of a peptide antigen representing the receptor binding domain of Pseudomonas aeruginosa.
Biochemistry 1993;32(49):13432-40.
1993: G D Henry; Shinsaku Maruta; M Ikebe; Brian D Sykes
Observation of multiple myosin subfragment 1-ADP-fluoroberyllate complexes by 19F NMR spectroscopy.
Biochemistry 1993;32(39):10451-6.
1993: H Chao; Peter L Davies; Brian D Sykes; F D Sönnichsen
Use of proline mutants to help solve the NMR solution structure of type III antifreeze protein.
Protein science : a publication of the Protein Society 1993;2(9):1411-28.
1993: David S Wishart; Brian D Sykes; F M Richards
Improved synthetic methods for the selective deuteration of aromatic amino acids: applications of selective protonation towards the identification of protein folding intermediates through nuclear magnetic resonance.
Biochimica et biophysica acta 1993;1164(1):36-46.
1993: N E Zhou; Cyril M Kay; Brian D Sykes; Robert S Hodges
A single-stranded amphipathic alpha-helix in aqueous solution: design, structural characterization, and its application for determining alpha-helical propensities of amino acids.
Biochemistry 1993;32(24):6190-7.
1993: W A Findlay; Brian D Sykes
1H-NMR resonance assignments, secondary structure, and global fold of the TR1C fragment of turkey skeletal troponin C in the calcium-free state.
Biochemistry 1993;32(13):3461-7.
1993: Shinsaku Maruta; G D Henry; Brian D Sykes; M Ikebe
Formation of the stable myosin-ADP-aluminum fluoride and myosin-ADP-beryllium fluoride complexes and their analysis using 19F NMR.
The Journal of biological chemistry 1993;268(10):7093-100.
1993: F D Sönnichsen; Brian D Sykes; H Chao; Peter L Davies
The nonhelical structure of antifreeze protein type III.
Science (New York, N.Y.) 1993;259(5098):1154-7.
1993: James D Baleja; G W Buchko; Michael Weinfeld; Brian D Sykes
Characterization of gamma-radiation induced decomposition products of thymidine-containing dinucleoside monophosphates by nuclear magnetic resonance spectroscopy.
Journal of biomolecular structure & dynamics 1993;10(4):747-62.
1993: A Patricia Campbell; Brian D Sykes
The two-dimensional transferred nuclear Overhauser effect: theory and practice.
Annual review of biophysics and biomolecular structure 1993;22():99-122.
1992: Carolyn Slupsky; Gary Shaw; A Patricia Campbell; Brian D Sykes
A 1H NMR study of a ternary peptide complex that mimics the interaction between troponin C and troponin I.
Protein science : a publication of the Protein Society 1992;1(12):1595-603.
1992: A Patricia Campbell; Jennifer E Van Eyk; Robert S Hodges; Brian D Sykes
Interaction of troponin I and troponin C: use of the two-dimensional transferred nuclear Overhauser effect to determine the structure of a Gly-110 inhibitory troponin I peptide analog when bound to cardiac troponin C.
Biochimica et biophysica acta 1992;1160(1):35-54.
1992: Joyce R Pearlstone; W D McCubbin; Cyril M Kay; Brian D Sykes; Lawrence B Smillie
Spectroscopic analysis of a methionine-48 to tyrosine mutant of chicken troponin C.
Biochemistry 1992;31(40):9703-8.
1992: Gary Shaw; Robert S Hodges; Brian D Sykes
Determination of the solution structure of a synthetic two-site calcium-binding homodimeric protein domain by NMR spectroscopy.
Biochemistry 1992;31(40):9572-80.
1992: F D Sönnichsen; Jennifer E Van Eyk; Robert S Hodges; Brian D Sykes
Effect of trifluoroethanol on protein secondary structure: an NMR and CD study using a synthetic actin peptide.
Biochemistry 1992;31(37):8790-8.
1992: J Wang; H Liu; Brian D Sykes; Robert O Ryan
31P-NMR study of the phospholipid moiety of lipophorin subspecies.
Biochemistry 1992;31(37):8706-12.
1992: O D Monera; Gary Shaw; B Y Zhu; Brian D Sykes; Cyril M Kay; Robert S Hodges
Role of interchain alpha-helical hydrophobic interactions in Ca2+ affinity, formation, and stability of a two-site domain in troponin C.
Protein science : a publication of the Protein Society 1992;1(7):945-55.
1992: G D Henry; Brian D Sykes
Assignment of amide 1H and 15N NMR resonances in detergent-solubilized M13 coat protein: a model for the coat protein dimer.
Biochemistry 1992;31(23):5284-97.
1992: Gary Shaw; Robert S Hodges; Brian D Sykes
Stoichiometry of calcium binding to a synthetic heterodimeric troponin-C domain.
Biopolymers 1992;32(4):391-7.
1991: James D Baleja; W F Anderson; Brian D Sykes
Different interactions of Cro repressor dimer with the left and right halves of OR3 operator DNA.
The Journal of biological chemistry 1991;266(33):22115-24.
1991: A Patricia Campbell; Brian D Sykes
Interaction of troponin I and troponin C. Use of the two-dimensional nuclear magnetic resonance transferred nuclear Overhauser effect to determine the structure of the inhibitory troponin I peptide when bound to skeletal troponin C.
Journal of molecular biology 1991;222(2):405-21.
1991: A Patricia Campbell; Brian D Sykes
Effects of internal motions on the development of the two-dimensional transferred nuclear Overhauser effect.
Journal of biomolecular NMR 1991;1(4):391-402.
1991: A Patricia Campbell; P J Cachia; Brian D Sykes
Interaction of troponin I and troponin C: 19F NMR studies of the binding of the inhibitory troponin I peptide to turkey skeletal troponin C.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1991;69(9):674-81.
1991: Gary Shaw; Robert S Hodges; Brian D Sykes
Probing the relationship between alpha-helix formation and calcium affinity in troponin C: 1H NMR studies of calcium binding to synthetic and variant site III helix-loop-helix peptides.
Biochemistry 1991;30(34):8339-47.
1991: James D Baleja; Brian D Sykes
Comparison of the structures of operator DNA free and in complex with lambda repressor.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1991;69(2-3):202-5.
1990: James D Baleja; Markus Germann; J H van de Sande; Brian D Sykes
Solution conformation of purine-pyrimidine DNA octamers using nuclear magnetic resonance, restrained molecular dynamics and NOE-based refinement.
Journal of molecular biology 1990;215(3):411-28.
1990: Gary Shaw; Robert S Hodges; Brian D Sykes
Calcium-induced peptide association to form an intact protein domain: 1H NMR structural evidence.
Science (New York, N.Y.) 1990;249(4966):280-3.
1990: G D Henry; Brian D Sykes
Hydrogen exchange kinetics in a membrane protein determined by 15N NMR spectroscopy: use of the INEPT experiment to follow individual amides in detergent-solubilized M13 coat protein.
Biochemistry 1990;29(26):6303-13.
1990: James D Baleja; R T Pon; Brian D Sykes
Solution structure of phage lambda half-operator DNA by use of NMR, restrained molecular dynamics, and NOE-based refinement.
Biochemistry 1990;29(20):4828-39.
1990: G D Henry; Brian D Sykes
Detergent-solubilized M13 coat protein exists as an asymmetric dimer. Observation of individual monomers by 15N, 13C and 1H nuclear magnetic resonance spectroscopy.
Journal of molecular biology 1990;212(1):11-4.
1990: B J Marsden; Gary Shaw; Brian D Sykes
Calcium binding proteins. Elucidating the contributions to calcium affinity from an analysis of species variants and peptide fragments.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(3):587-601.
1990: G D Henry; Brian D Sykes
Structure and dynamics of detergent-solubilized M13 coat protein (an integral membrane protein) determined by 13C and 15N nuclear magnetic resonance spectroscopy.
Biochemistry and cell biology = Biochimie et biologie cellulaire 1990;68(1):318-29.
1989: L F Golden; D C Corson; Brian D Sykes; D Banville; John P MacManus
Site-specific mutants of oncomodulin. 1H NMR and optical stopped-flow studies of the effect on the metal binding properties of an Asp59----Glu59 substitution in the calcium-specific site.
The Journal of biological chemistry 1989;264(34):20314-9.
1989: B J Marsden; Robert S Hodges; Brian D Sykes
A 1H NMR determination of the solution conformation of a synthetic peptide analogue of calcium-binding site III of rabbit skeletal troponin C.
Biochemistry 1989;28(22):8839-47.
1989: J D O'Neil; Brian D Sykes
Side-chain dynamics of a detergent-solubilized membrane protein: measurement of tryptophan and glutamine hydrogen-exchange rates in M13 coat protein by 1H NMR spectroscopy.
Biochemistry 1989;28(16):6736-45.
1989: John P MacManus; C M Hutnik; Brian D Sykes; A G Szabo; T C Williams; D Banville
Characterization and site-specific mutagenesis of the calcium-binding protein oncomodulin produced by recombinant bacteria.
The Journal of biological chemistry 1989;264(6):3470-7.
1989: J D O'Neil; Brian D Sykes
NMR studies of the influence of dodecyl sulfate on the amide hydrogen exchange kinetics of a micelle-solubilized hydrophobic tripeptide.
Biochemistry 1989;28(2):699-707.
1989: A Patricia Campbell; Brian D Sykes
Conformation of a troponin-I peptide bound to troponin-C as determined by 1H NMR.
Advances in experimental medicine and biology 1989;255():195-204.
1988: C Sanders; Brian D Sykes; Lawrence B Smillie
Comparison of the structure and dynamics of chicken gizzard and rabbit cardiac tropomyosins: 1H NMR spectroscopy and measurement of amide hydrogen exchange rates.
Biochemistry 1988;27(18):7000-8.
1988: B J Marsden; Robert S Hodges; Brian D Sykes
1H-NMR studies of synthetic peptide analogues of calcium-binding site III of rabbit skeletal troponin C: effect on the lanthanum affinity of the interchange of aspartic acid and asparagine residues at the metal ion coordinating positions.
Biochemistry 1988;27(11):4198-206.
1988: J D O'Neil; Brian D Sykes
Structure and dynamics of a detergent-solubilized membrane protein: measurement of amide hydrogen exchange rates in M13 coat protein by 1H NMR spectroscopy.
Biochemistry 1988;27(8):2753-62.
1988: Ruthven N A H Lewis; Brian D Sykes; Ronald N McElhaney
Thermotropic phase behavior of model membranes composed of phosphatidylcholines containing cis-monounsaturated acyl chain homologues of oleic acid: differential scanning calorimetric and 31P NMR spectroscopic studies.
Biochemistry 1988;27(3):880-7.
1987: Ruthven N A H Lewis; Brian D Sykes; Ronald N McElhaney
Thermotropic phase behavior of model membranes composed of phosphatidylcholines containing dl-methyl anteisobranched fatty acids. 1. Differential scanning calorimetric and 31P NMR spectroscopic studies.
Biochemistry 1987;26(13):4036-44.
1987: G D Henry; Joel Weiner; Brian D Sykes
Backbone dynamics of a model membrane protein: measurement of individual amide hydrogen-exchange rates in detergent-solubilized M13 coat protein using 13C NMR hydrogen/deuterium isotope shifts.
Biochemistry 1987;26(12):3626-34.
1987: G D Henry; Joel Weiner; Brian D Sykes
Backbone dynamics of a model membrane protein: assignment of the carbonyl carbon 13C NMR resonances in detergent-solubilized M13 coat protein.
Biochemistry 1987;26(12):3619-26.
1987: T C Williams; D C Corson; Brian D Sykes; John P MacManus
Oncomodulin. 1H NMR and optical stopped-flow spectroscopic studies of its solution conformation and metal-binding properties.
The Journal of biological chemistry 1987;262(13):6248-56.
1987: Joel Weiner; H D Dettman; G D Henry; J D O'Neil; Brian D Sykes
Nuclear magnetic resonance studies of a model membrane protein (M13 coat protein) reconstituted in detergent micelles and phospholipid vesicles.
Biochemical Society transactions 1987;15(1):81-5.
1986: T C Williams; D C Corson; K Oikawa; W D McCubbin; C M Kay; Brian D Sykes
1H NMR spectroscopic studies of calcium-binding proteins. 3. Solution conformations of rat apo-alpha-parvalbumin and metal-bound rat alpha-parvalbumin.
Biochemistry 1986;25(7):1835-46.
1986: T C Williams; D C Corson; W D McCubbin; K Oikawa; C M Kay; Brian D Sykes
1H NMR spectroscopic studies of calcium-binding proteins. 2. Histidine microenvironments in alpha- and beta-parvalbumins as determined by protonation and laser photochemically induced dynamic nuclear polarization effects.
Biochemistry 1986;25(7):1826-34.
1986: D C Corson; T C Williams; L E Kay; Brian D Sykes
1H NMR spectroscopic studies of calcium-binding proteins. 1. Stepwise proteolysis of the C-terminal alpha-helix of a helix-loop-helix metal-binding domain.
Biochemistry 1986;25(7):1817-26.
1986: G D Henry; Joel Weiner; Brian D Sykes
Backbone dynamics of a model membrane protein: 13C NMR spectroscopy of alanine methyl groups in detergent-solubilized M13 coat protein.
Biochemistry 1986;25(3):590-8.
1986: G D Henry; J D O'Neil; Joel Weiner; Brian D Sykes
Hydrogen exchange in the hydrophilic regions of detergent-solubilized M13 coat protein detected by 13C nuclear magnetic resonance isotope shifts.
Biophysical journal 1986;49(1):329-31.
1983: D C Corson; T C Williams; Brian D Sykes
Calcium binding proteins: optical stopped-flow and proton nuclear magnetic resonance studies of the binding of the lanthanide series of metal ions to parvalbumin.
Biochemistry 1983;22(25):5882-9.