Megan Sykes

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Graft vs Host Disease

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Porcheray F; Wong W; Saidman S L; De Vito J; Girouard T C; Chittenden M; Shaffer J; Tolkoff-Rubin N; Dey B R; Spitzer T R; Colvin R B; Cosimi A B; Kawai T; Sachs D H; Sykes M; Zorn E
B-cell immunity in the context of T-cell tolerance after combined kidney and bone marrow transplantation in humans.
Brainard Diana M; Seung Edward; Frahm Nicole; Cariappa Annaiah; Bailey Charles C; Hart William K; Shin Hae-Sook; Brooks Sarah F; Knight Heather L; Eichbaum Quentin; Yang Yong-Guang; Sykes Megan; Walker Bruce D; Freeman Gordon J; Pillai Shiv; Westmoreland Susan V; Brander Christian; Luster Andrew D; Tager Andrew M
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice.
Habiro K; Sykes M; Yang Y-G
Induction of human T-cell tolerance to pig Xenoantigens via thymus transplantation in mice with an established human immune system.

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All Publications

2009: Porcheray F; Wong W; Saidman S L; De Vito J; Girouard T C; Chittenden M; Shaffer J; Tolkoff-Rubin N; Dey B R; Spitzer T R; Colvin R B; Cosimi A B; Kawai T; Sachs D H; Sykes M; Zorn E
B-cell immunity in the context of T-cell tolerance after combined kidney and bone marrow transplantation in humans.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(9):2126-35.
2009: Brainard Diana M; Seung Edward; Frahm Nicole; Cariappa Annaiah; Bailey Charles C; Hart William K; Shin Hae-Sook; Brooks Sarah F; Knight Heather L; Eichbaum Quentin; Yang Yong-Guang; Sykes Megan; Walker Bruce D; Freeman Gordon J; Pillai Shiv; Westmoreland Susan V; Brander Christian; Luster Andrew D; Tager Andrew M
Induction of robust cellular and humoral virus-specific adaptive immune responses in human immunodeficiency virus-infected humanized BLT mice.
Journal of virology 2009;83(14):7305-21.
2009: Habiro K; Sykes M; Yang Y-G
Induction of human T-cell tolerance to pig Xenoantigens via thymus transplantation in mice with an established human immune system.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2009;9(6):1324-9.
2009: Sachs David H; Sykes Megan; Yamada Kazuhiko
Achieving tolerance in pig-to-primate xenotransplantation: reality or fantasy.
Transplant immunology 2009;21(2):101-5.
2009: Sykes Megan
Mechanisms of transplantation tolerance in animals and humans.
Transplantation 2009;87(9 Suppl):S67-9.
2009: Wang Hui; Asavaroengchai Wannee; Yeap Beow Yong; Wang Min-Guang; Wang Shumei; Sykes Megan; Yang Yong-Guang
Paradoxical effects of IFN-gamma in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury.
Blood 2009;113(15):3612-9.
2009: Kurtz Josef; Raval Forum; Vallot Casey; Der Jayden; Sykes Megan
CTLA-4 on alloreactive CD4 T cells interacts with recipient CD80/86 to promote tolerance.
Blood 2009;113(15):3475-84.
2009: Sykes Megan
Hematopoietic cell transplantation for tolerance induction: animal models to clinical trials.
Transplantation 2009;87(3):309-16.
2008: Fudaba Yasuhiro; Onoe Takashi; Chittenden Meredith; Shimizu Akira; Shaffer Juanita M; Bronson Roderick; Sykes Megan
Abnormal regulatory and effector T cell function predispose to autoimmunity following xenogeneic thymic transplantation.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(11):7649-59.
2008: Chakraverty Ronjon; Flutter Barry; Fallah-Arani Farnaz; Eom Hyeon-Seok; Means Terry; Andreola Giovanna; Schwarte Sebastian; Buchli Jennifer; Cotter Pete; Zhao Guiling; Sykes Megan
The host environment regulates the function of CD8+ graft-versus-host-reactive effector cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(10):6820-8.
2008: Koporc Z; Pilat N; Nierlich P; Blaha P; Bigenzahn S; Pree I; Selzer E; Sykes M; Muehlbacher F; Wekerle T
Murine mobilized peripheral blood stem cells have a lower capacity than bone marrow to induce mixed chimerism and tolerance.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2008;8(10):2025-36.
2008: Haspot Fabienne; Bardwell Philip D; Zhao Guiling; Sykes Megan
High antigen levels do not preclude B-cell tolerance induction to alpha1,3-Gal via mixed chimerism.
Xenotransplantation 2008;15(5):313-20.
2008: Fehr Thomas; Wang Sophia; Haspot Fabienne; Kurtz Josef; Blaha Peter; Hogan Timothy; Chittenden Meredith; Wekerle Thomas; Sykes Megan
Rapid deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(6):4371-80.
2008: Haspot Fabienne; Fehr Thomas; Gibbons Carrie; Zhao Guiling; Hogan Timothy; Honjo Tasuku; Freeman Gordon J; Sykes Megan
Peripheral deletional tolerance of alloreactive CD8 but not CD4 T cells is dependent on the PD-1/PD-L1 pathway.
Blood 2008;112(5):2149-55.
2008: Shimizu Ichiro; Fudaba Yasuhiro; Shimizu Akira; Yang Yong-Guang; Sykes Megan
Comparison of human T cell repertoire generated in xenogeneic porcine and human thymus grafts.
Transplantation 2008;86(4):601-10.
2008: Fehr Thomas; Haspot Fabienne; Mollov Joshua; Chittenden Meredith; Hogan Timothy; Sykes Megan
Alloreactive CD8 T cell tolerance requires recipient B cells, dendritic cells, and MHC class II.
Journal of immunology (Baltimore, Md. : 1950) 2008;181(1):165-73.
2008: Gibbons Carrie; Sykes Megan
Manipulating the immune system for anti-tumor responses and transplant tolerance via mixed hematopoietic chimerism.
Immunological reviews 2008;223():334-60.
2008: Ge Xupeng; Brown Julia; Sykes Megan; Boussiotis Vassiliki A
CD134-allodepletion allows selective elimination of alloreactive human T cells without loss of virus-specific and leukemia-specific effectors.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2008;14(5):518-30.
2008: Tonomura Noriko; Habiro Katsuyoshi; Shimizu Akira; Sykes Megan; Yang Yong-Guang
Antigen-specific human T-cell responses and T cell-dependent production of human antibodies in a humanized mouse model.
Blood 2008;111(8):4293-6.
2008: Sykes Megan
2007 IXA Presidential Address. Progress toward an ideal source animal: opportunities and challenges in a changing world.
Xenotransplantation 2008;15(1):7-13.
2008: Kawai Tatsuo; Cosimi A Benedict; Spitzer Thomas R; Tolkoff-Rubin Nina; Suthanthiran Manikkam; Saidman Susan L; Shaffer Juanita; Preffer Frederic I; Ding Ruchuang; Sharma Vijay; Fishman Jay A; Dey Bimalangshu; Ko Dicken S C; Hertl Martin; Goes Nelson B; Wong Waichi; Williams Winfred W; Colvin Robert B; Sykes Megan; Sachs David H
HLA-mismatched renal transplantation without maintenance immunosuppression.
The New England journal of medicine 2008;358(4):353-61.
2007: Hongo David; Hadidi Sima; Damrauer Scott; Garrigue Valerie; Kraft Daniel; Sachs David H; Nikolic Boris; Sykes Megan
Porcine thymic grafts protect human thymocytes from HIV-1-induced destruction.
The Journal of infectious diseases 2007;196(6):900-10.
2007: Sykes M
Immune tolerance: mechanisms and application in clinical transplantation.
Journal of internal medicine 2007;262(3):288-310.
2007: Kawahara T; Rodriguez-Barbosa J-I; Zhao Y; Zhao G; Sykes M
Global unresponsiveness as a mechanism of natural killer cell tolerance in mixed xenogeneic chimeras.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(9):2090-7.
2007: Sachs David H; Yamada Kazuhiko; Robson Simon C; Fishman Jay A; Shimizu Akira; Colvin Robert B; Sykes Megan
GalT-KO pigs: is the cup half empty or half full?
Transplantation 2007;84(1):12-4.
2007: Shaffer Juanita; Villard Jean; Means Terry K; Alexander Stephen; Dombkowski David; Dey Bimalangshu R; McAfee Steven; Ballen Karen K; Saidman Susan; Preffer Frederic I; Sachs David H; Spitzer Thomas R; Sykes Megan
Regulatory T-cell recovery in recipients of haploidentical nonmyeloablative hematopoietic cell transplantation with a humanized anti-CD2 mAb, MEDI-507, with or without fludarabine.
Experimental hematology 2007;35(7):1140-52.
2007: Yang Yong-Guang; Sykes Megan
Xenotransplantation: current status and a perspective on the future.
Nature reviews. Immunology 2007;7(7):519-31.
2007: Dey B R; Shaffer J; Yee A J; McAfee S; Caron M; Power K; Ting D T; Colby C; Preffer F; Ballen K; Attar E; Saidman S; Tarbell N; Sachs D; Sykes M; Spitzer T R
Comparison of outcomes after transplantation of peripheral blood stem cells versus bone marrow following an identical nonmyeloablative conditioning regimen.
Bone marrow transplantation 2007;40(1):19-27.
2007: Sykes Megan; Pierson Richard N; O'Connell Philip; D'Apice Anthony; Cowan Peter; Cozzi Emanuele; Dorling Anthony; Hering Bernhard; Leventhal Joseph; Soulillou Jean-Paul
Reply to 'Critics slam Russian trial to test pig pancreas for diabetes'.
Nature medicine 2007;13(6):662-3.
2007: Koyama I; Nadazdin O; Boskovic S; Ochiai T; Smith R N; Sykes M; Sogawa H; Murakami T; Strom T B; Colvin R B; Sachs D H; Benichou G; Cosimi A B; Kawai T
Depletion of CD8 memory T cells for induction of tolerance of a previously transplanted kidney allograft.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007;7(5):1055-61.
2007: Pree Ines; Bigenzahn Sinda; Fuchs Dietmar; Koporc Zvonimir; Nierlich Patrick; Winkler Christiana; Brandacher Gerald; Sykes Megan; Muehlbacher Ferdinand; Langer Felix; Wekerle Thomas
CTLA4Ig promotes the induction of hematopoietic chimerism and tolerance independently of Indoleamine-2,3-dioxygenase.
Transplantation 2007;83(5):663-7.
2007: Shimizu Ichiro; Kawahara Toshiyasu; Haspot Fabienne; Bardwell Philip D; Carroll Michael C; Sykes Megan
B-cell extrinsic CR1/CR2 promotes natural antibody production and tolerance induction of anti-alphaGAL-producing B-1 cells.
Blood 2007;109(4):1773-81.
2007: Papeta Natalia; Chen Tao; Vianello Fabrizio; Gererty Lyle; Malik Ashish; Mok Ying-Ting; Tharp William G; Bagley Jessamyn; Zhao Guiling; Stevceva Liljana; Yoon Victor; Sykes Megan; Sachs David; Iacomini John; Poznansky Mark C
Long-term survival of transplanted allogeneic cells engineered to express a T cell chemorepellent.
Transplantation 2007;83(2):174-83.
2007: Asavaroengchai Wannee; Wang Hui; Wang Shumei; Wang Lan; Bronson Roderick; Sykes Megan; Yang Yong-Guang
An essential role for IFN-gamma in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2007;13(1):46-55.
2007: Sykes Megan; Cozzi Emanuele; D'Apice Anthony J F; Pierson Richard N; O'Connell Phillip; Cowan Peter; Dorling Anthony; Hering Bernard; Soulillou Jean-Paul; Sandrin Mauro
Response to Valdes-Gonzalez ''Clinical trial of islet xenotransplantation in Mexico''.
Xenotransplantation 2007;14(1):90-1.
2007: Wang Hui; VerHalen Jon; Madariaga Maria Lucia; Xiang Shuanglin; Wang Shumei; Lan Ping; Oldenborg Per-Arne; Sykes Megan; Yang Yong-Guang
Attenuation of phagocytosis of xenogeneic cells by manipulating CD47.
Blood 2007;109(2):836-42.
2007: Sykes Megan
Mechanisms of tolerance induced via mixed chimerism.
Frontiers in bioscience : a journal and virtual library 2007;12():2922-34.
2006: Boskovic Svjetlan; Kawai Tatsuo; Smith Rex-Neal; Wee Siew-Lin; Nadazdin Ognjenka; Koyama Ichiro; Saidman Susan; Cardarelli Francesca; Elias Nahel; Sykes Megan; Strom Terry; Colvin Robert B; Sachs David H; Cosimi A Benedict
Monitoring antidonor alloantibodies as a predictive assay for renal allograft tolerance/long-term observations in nonhuman primates.
Transplantation 2006;82(6):819-25.
2006: Saito Toshiki I; Rubio Marie T; Sykes Megan
Clinical relevance of recipient leukocyte infusion as antitumor therapy following nonmyeloablative allogeneic hematopoietic cell transplantation.
Experimental hematology 2006;34(9):1271-7.
2006: Sykes Megan; Cozzi Emanuele; d'Apice Anthony; Pierson Robin; O'Connell Philip; Cowan Peter; Dorling Anthony; Hering Bernhard; Leventhal Joseph; Rees Michael; Sandrin Mauro
Clinical trial of islet xenotransplantation in Mexico.
Xenotransplantation 2006;13(5):371-2.
2006: Fudaba Y; Spitzer T R; Shaffer J; Kawai T; Fehr T; Delmonico F; Preffer F; Tolkoff-Rubin N; Dey B R; Saidman S L; Kraus A; Bonnefoix T; McAfee S; Power K; Kattleman K; Colvin R B; Sachs D H; Cosimi A B; Sykes M
Myeloma responses and tolerance following combined kidney and nonmyeloablative marrow transplantation: in vivo and in vitro analyses.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2006;6(9):2121-33.
2006: Chakraverty Ronjon; Eom Hyeon-Seok; Sachs Jessica; Buchli Jennifer; Cotter Pete; Hsu Richard; Zhao Guiling; Sykes Megan
Host MHC class II+ antigen-presenting cells and CD4 cells are required for CD8-mediated graft-versus-leukemia responses following delayed donor leukocyte infusions.
Blood 2006;108(6):2106-13.
2006: Chakraverty Ronjon; Côté Daniel; Buchli Jennifer; Cotter Pete; Hsu Richard; Zhao Guiling; Sachs Teviah; Pitsillides Costas M; Bronson Roderick; Means Terry; Lin Charles; Sykes Megan
An inflammatory checkpoint regulates recruitment of graft-versus-host reactive T cells to peripheral tissues.
The Journal of experimental medicine 2006;203(8):2021-31.
2006: Ito Hiroshi; Takeuchi Yasuo; Shaffer Juanita; Sykes Megan
Anti-CD40L monoclonal antibodies can replace anti-CD4 monoclonal antibodies for the nonmyeloablative induction of mixed xenogeneic chimerism.
Transplantation 2006;82(2):251-7.
2006: Rubio Marie-Therese; Zhao Guiling; Buchli Jennifer; Chittenden Meredith; Sykes Megan
Role of indirect allo- and autoreactivity in anti-tumor responses induced by recipient leukocyte infusions (RLI) in mixed chimeras prepared with nonmyeloablative conditioning.
Clinical immunology (Orlando, Fla.) 2006;120(1):33-44.
2006: Mapara Markus Y; Leng Corinna; Kim Yong-Mi; Bronson Roderick; Lokshin Anna; Luster Andrew; Sykes Megan
Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHR.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(6):623-34.
2006: Xu Yuanxin; Yang Yong-Guang; Ohdan Hideki; Ryan David; Harper David; Wu Cecelia; Kruger-Grey Huw S; Thall Aron D; Awwad Michel; Sykes Megan
Characterization of anti-Gal antibody-producing cells of baboons and humans.
Transplantation 2006;81(6):940-8.
2006: Koporc Zvonimir; Bigenzahn Sinda; Blaha Peter; Fariborz Elahi; Selzer Edgar; Sykes Megan; Muehlbacher Ferdinand; Wekerle Thomas
Induction of mixed chimerism through transplantation of CD45-congenic mobilized peripheral blood stem cells after nonmyeloablative irradiation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2006;12(3):284-92.
2006: Shimizu Ichiro; Smith Neal R; Zhao Guiling; Medof Edward; Sykes Megan
Decay-accelerating factor prevents acute humoral rejection induced by low levels of anti-alphaGal natural antibodies.
Transplantation 2006;81(1):95-100.
2006: Kawai Tatsuo; Sachs David H; Sykes Megan; Spitzer Thomas; Tolkoff-Rubin Nina; Saidman Susan; Ko Dicken; Dey Bimalangshu; Colvin Rober B; Cosimi A Benedict
My most interesting cases.
Clinical transplants 2006;():580-2.
2005: Yamamoto Shin; Lavelle John M; Vagefi Parsia A; Arakawa Hitoshi; Samelson-Jones Emma; Moran Shannon; Teranishi Katsuhito; Kamano Chisako; Fishman Jay; Awwad Michel; Neville David M; Shimizu Akira; Sykes Megan; Sachs David H; Yamada Kazuhiko
Vascularized thymic lobe transplantation in a pig-to-baboon model: a novel strategy for xenogeneic tolerance induction and T-cell reconstitution.
Transplantation 2005;80(12):1783-90.
2005: Eom Hyeon-Seok; Rubio Marie-Therese; Means Terry K; Luster Andrew D; Sykes Megan
T-cell P/E-selectin ligand alpha(1,3)fucosylation is not required for graft-vs-host disease induction.
Experimental hematology 2005;33(12):1564-73.
2005: Rubio Marie T; Means Terry K; Chakraverty Ronjon; Shaffer Juanita; Fudaba Yasuhiro; Chittenden Meredith; Luster Andrew D; Sykes Megan
Maturation of human monocyte-derived dendritic cells (MoDCs) in the presence of prostaglandin E2 optimizes CD4 and CD8 T cell-mediated responses to protein antigens: role of PGE2 in chemokine and cytokine expression by MoDCs.
International immunology 2005;17(12):1561-72.
2005: Kawahara T; Shimizu I; Ohdan H; Zhao G; Sykes M
Differing mechanisms of early and late B cell hyporesponsiveness induced by mixed chimerism.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2005;5(12):2821-9.
2005: Rodríguez-Barbosa José-Ignacio; Haller Gary W; Zhao Guiling; Sachs David H; Sykes Megan
Host thymectomy and cyclosporine lead to unstable skin graft tolerance after class I mismatched allogeneic neonatal thymic transplantation in mice.
Transplant immunology 2005;15(1):25-33.
2005: Fehr Thomas; Takeuchi Yasuo; Kurtz Josef; Wekerle Thomas; Sykes Megan
Early regulation of CD8 T cell alloreactivity by CD4+CD25- T cells in recipients of anti-CD154 antibody and allogeneic BMT is followed by rapid peripheral deletion of donor-reactive CD8+ T cells, precluding a role for sustained regulation.
European journal of immunology 2005;35(9):2679-90.
2005: Blaha Peter; Bigenzahn Sinda; Koporc Zvonimir; Sykes Megan; Muehlbacher Ferdinand; Wekerle Thomas
Short-term immunosuppression facilitates induction of mixed chimerism and tolerance after bone marrow transplantation without cytoreductive conditioning.
Transplantation 2005;80(2):237-43.
2005: Rubio Marie-Therese; Saito Toshiki I; Kattleman Kristin; Zhao Guiling; Buchli Jennifer; Sykes Megan
Mechanisms of the antitumor responses and host-versus-graft reactions induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: a critical role for recipient CD4+ T cells and recipient leukocyte infusion-derived IFN-gamma-producing CD8+ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(2):665-76.
2005: Sykes Megan; Nikolic Boris
Treatment of severe autoimmune disease by stem-cell transplantation.
Nature 2005;435(7042):620-7.
2005: Giovino Maria A; Wang Hui; Sykes Megan; Yang Yong-Guang
Role of VLA-4 and VLA-5 in ex vivo maintenance of human and pig hematopoiesis in human stroma-supported long-term cultures.
Experimental hematology 2005;33(3):363-70.
2005: Sykes Megan; Shimizu Ichiro; Kawahara Toshiyasu
Mixed hematopoietic chimerism for the simultaneous induction of T and B cell tolerance.
Transplantation 2005;79(3 Suppl):S28-9.
2005: Dey Bimalangshu R; McAfee Steven; Colby Christine; Cieply Kathy; Caron Martin; Saidman Susan; Preffer Frederic; Shaffer Juanita; Tarbell Nancy; Sackstein Robert; Sachs David; Sykes Megan; Spitzer Thomas R
Anti-tumour response despite loss of donor chimaerism in patients treated with non-myeloablative conditioning and allogeneic stem cell transplantation.
British journal of haematology 2005;128(3):351-9.
2005: Yamada Kazuhiko; Yazawa Koji; Shimizu Akira; Iwanaga Takehiro; Hisashi Yosuke; Nuhn Matthew; O'Malley Patricia; Nobori Shuji; Vagefi Parsia A; Patience Clive; Fishman Jay; Cooper David K C; Hawley Robert J; Greenstein Julia; Schuurman Henk-Jan; Awwad Michel; Sykes Megan; Sachs David H
Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue.
Nature medicine 2005;11(1):32-4.
2004: Eguchi Hiroshi; Knosalla Christoph; Lan Ping; Cheng Jane; Diouf Bintou; Wang Lan; Abe Masahiro; Schuurman Henk-Jan; Sachs David H; Sykes Megan; Cooper David K C; Yang Yong-Guang
T cells from presensitized donors fail to cause graft-versus-host disease in a pig-to-mouse xenotransplantation model.
Transplantation 2004;78(11):1609-17.
2004: Sykes Megan; d'Apice Anthony; Sandrin Mauro;
Position paper of the Ethics Committee of the International Xenotransplantation Association.
Transplantation 2004;78(8):1101-7.
2004: Kurtz Josef; Wekerle Thomas; Sykes Megan
Tolerance in mixed chimerism - a role for regulatory cells?
Trends in immunology 2004;25(10):518-23.
2004: Fehr Thomas; Sykes Megan
Tolerance induction in clinical transplantation.
Transplant immunology 2004;13(2):117-30.
2004: Yang Yong-Guang; Wood James C; Lan Ping; Wilkinson Robert A; Sykes Megan; Fishman Jay A; Patience Clive
Mouse retrovirus mediates porcine endogenous retrovirus transmission into human cells in long-term human-porcine chimeric mice.
The Journal of clinical investigation 2004;114(5):695-700.
2004: Kawai Tatsuo; Sogawa Hiroshi; Boskovic Svetlan; Abrahamian Gregory; Smith Rex-Neal; Wee Siew-Lin; Andrews David; Nadazdin Ognjenka; Koyama Ichiro; Sykes Megan; Winn Henry J; Colvin Robert B; Sachs David H; Cosimi A Benedict
CD154 blockade for induction of mixed chimerism and prolonged renal allograft survival in nonhuman primates.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(9):1391-8.
2004: Kurtz Josef; Shaffer Juanita; Lie Ariadne; Anosova Natalie; Benichou Gilles; Sykes Megan
Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: evidence for anergy and deletion but not regulatory cells.
Blood 2004;103(11):4336-43.
2004: Sykes Megan; Sandrin Mauro; Cozzi Emanuele; Rees Michael A
World Health Organization resolution on xenotransplantation.
Xenotransplantation 2004;11(3):224-5.
2004: Lan Ping; Wang Lan; Diouf Bintou; Eguchi Hiroshi; Su Hui; Bronson Roderick; Sachs David H; Sykes Megan; Yang Yong-Guang
Induction of human T-cell tolerance to porcine xenoantigens through mixed hematopoietic chimerism.
Blood 2004;103(10):3964-9.
2004: Wekerle Thomas; Sykes Megan
Induction of tolerance.
Surgery 2004;135(4):359-64.
2004: Ito Hiroshi; Takeuchi Yasuo; Shaffer Juanita; Sykes Megan
Local irradiation enhances congenic donor pluripotent hematopoietic stem cell engraftment similarly in irradiated and nonirradiated sites.
Blood 2004;103(5):1949-54.
2004: Sykes Megan; Sandrin Mauro; Cozzi Emanuele;
International cooperation on xenotransplantation.
Nature medicine 2004;10(2):119.
2004: Nikolic Boris; Takeuchi Yasuo; Leykin Igor; Fudaba Yasuhiro; Smith R Neal; Sykes Megan
Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity.
Diabetes 2004;53(2):376-83.
2004: Takeuchi Yasuo; Ito Hiroshi; Kurtz Josef; Wekerle Thomas; Ho Leon; Sykes Megan
Earlier low-dose TBI or DST overcomes CD8+ T-cell-mediated alloresistance to allogeneic marrow in recipients of anti-CD40L.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004;4(1):31-40.
2004: Kim Yong-Mi; Mapara Markus Y; Down Julian D; Johnson Kevin W; Boisgerault Florence; Akiyama Yoshinobu; Benichou Gilles; Pelot Michele; Zhao Guiling; Sykes Megan
Graft-versus-host-reactive donor CD4 cells can induce T cell-mediated rejection of the donor marrow in mixed allogeneic chimeras prepared with nonmyeloablative conditioning.
Blood 2004;103(2):732-9.
2003: Kawahara Toshiyasu; Ohdan Hideki; Zhao Guiling; Yang Yong-Guang; Sykes Megan
Peritoneal cavity B cells are precursors of splenic IgM natural antibody-producing cells.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):5406-14.
2003: Koenecke Christian; Shaffer Juanita; Alexander Stephen I; Preffer Frederic; Dombkowski David; Saidman Susan L; Dey Bimalanghu; McAfee Steven; Spitzer Thomas R; Sykes Megan
NK cell recovery, chimerism, function, and recognition in recipients of haploidentical hematopoietic cell transplantation following nonmyeloablative conditioning using a humanized anti-CD2 mAb, Medi-507.
Experimental hematology 2003;31(10):911-23.
2003: Sykes Megan; Sandrin Mauro; D'Apice Anthony;
Guidelines for xenotransplantation.
The New England journal of medicine 2003;349(13):1294-5.
2003: Le Guern Annie C; Giovino Maria A; Abe Masahiro; Theodore Pierre R; Qi Jin; Down Julian D; Sachs David H; Sykes Megan; Yang Yong-Guang
Stem cell activity of porcine c-kit+ hematopoietic cells.
Experimental hematology 2003;31(9):833-40.
2003: Rubio Marie-Therese; Kim Yong-Mi; Sachs Teviah; Mapara Markus; Zhao Guiling; Sykes Megan
Antitumor effect of donor marrow graft rejection induced by recipient leukocyte infusions in mixed chimeras prepared with nonmyeloablative conditioning: critical role for recipient-derived IFN-gamma.
Blood 2003;102(6):2300-7.
2003: Mapara Markus Y; Kim Yong-Mi; Marx Julie; Sykes Megan
Donor lymphocyte infusion-mediated graft-versus-leukemia effects in mixed chimeras established with a nonmyeloablative conditioning regimen: extinction of graft-versus-leukemia effects after conversion to full donor chimerism.
Transplantation 2003;76(2):297-305.
2003: Kraus Annette B; Shaffer Juanita; Toh Han Chong; Preffer Frederic; Dombkowski David; Saidman Susan; Colby Christine; George Richard; McAfee Steven; Sackstein Robert; Dey Bimalangsu; Spitzer Thomas R; Sykes Megan
Early host CD8 T-cell recovery and sensitized anti-donor interleukin-2-producing and cytotoxic T-cell responses associated with marrow graft rejection following nonmyeloablative allogeneic bone marrow transplantation.
Experimental hematology 2003;31(7):609-21.
2003: Kurtz Josef; Lie Ariadne; Griffith Mathew; Eysaman Shannon; Shaffer Juanita; Anosova Natalie; Turka Laurence; Benichou Gilles; Sykes Megan
Lack of role for CsA-sensitive or Fas pathways in the tolerization of CD4 T cells via BMT and anti-CD40L.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2003;3(7):804-16.
2003: Daly Andrew; McAfee Steven; Dey Bimal; Colby Christine; Schulte Leah; Yeap Beow; Sackstein Robert; Tarbell Nancy J; Sachs David; Sykes Megan; Spitzer Thomas R
Nonmyeloablative bone marrow transplantation: Infectious complications in 65 recipients of HLA-identical and mismatched transplants.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2003;9(6):373-82.
2003: Zhao Yong; Rodriguez-Barbosa Jose-Ignacio; Shimizu Akira; Sachs David H; Sykes Megan
Despite efficient intrathymic negative selection of host-reactive T cells, autoimmune disease may develop in porcine thymus-grafted athymic mice: evidence for failure of regulatory mechanisms suppressing autoimmunity.
Transplantation 2003;75(11):1832-40.
2003: Zhao Yong; Ohdan Hideki; Manilay Jennifer O; Sykes Megan
NK cell tolerance in mixed allogeneic chimeras.
Journal of immunology (Baltimore, Md. : 1950) 2003;170(11):5398-405.
2003: Spitzer Thomas R; McAfee Steven L; Dey Bimalangshu R; Colby Christine; Hope James; Grossberg Howard; Preffer Frederic; Shaffer Juanita; Alexander Stephen I; Sachs David H; Sykes Megan
Nonmyeloablative haploidentical stem-cell transplantation using anti-CD2 monoclonal antibody (MEDI-507)-based conditioning for refractory hematologic malignancies.
Transplantation 2003;75(10):1748-51.
2003: Barth Rolf N; Yamamoto Shin; LaMattina John C; Kumagai Naoki; Kitamura Hiroshi; Vagefi Parsia A; Awwad Michel; Colvin Robert B; Cooper David K C; Sykes Megan; Sachs David H; Yamada Kazuhiko
Xenogeneic thymokidney and thymic tissue transplantation in a pig-to-baboon model: I. Evidence for pig-specific T-cell unresponsiveness.
Transplantation 2003;75(10):1615-24.
2003: Dey Bimalangshu R; McAfee Steven; Colby Christine; Sackstein Robert; Saidman Susan; Tarbell Nancy; Sachs David H; Sykes Megan; Spitzer Thomas R
Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced hematologic malignancies treated with nonmyeloablative conditioning and allogeneic bone marrow transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2003;9(5):320-9.
2003: Sykes Megan; d'Apice Anthony; Sandrin Mauro;
Position paper of the Ethics Committee of the International Xenotransplantation Association.
Xenotransplantation 2003;10(3):194-203.
2003: Blaha Peter; Bigenzahn Sinda; Koporc Zvonimir; Schmid Maximilian; Langer Felix; Selzer Edgar; Bergmeister Helga; Wrba Friedrich; Kurtz Josef; Kiss Christopher; Roth Erich; Muehlbacher Ferdinand; Sykes Megan; Wekerle Thomas
The influence of immunosuppressive drugs on tolerance induction through bone marrow transplantation with costimulation blockade.
Blood 2003;101(7):2886-93.
2003: Kim Yong-Mi; Sachs Teviah; Asavaroengchai Wannee; Bronson Roderick; Sykes Megan
Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720.
The Journal of clinical investigation 2003;111(5):659-69.
2003: Wu Anette; Yamada Kazuhiko; Neville David M; Awwad Michel; Wain John C; Shimizu Akira; Gojo Satoshi; Kitamura Hiroshi; Colvin Robert B; Cooper David K C; Sykes Megan; Sachs David H
Xenogeneic thymus transplantation in a pig-to-baboon model.
Transplantation 2003;75(3):282-91.
2003: Rodriguez-Barbosa Jose-Ignacio; Zhao Yong; Houser Stuart; Zhao Guiling; Sykes Megan
Fetal porcine thymus engraftment, survival and CD4 reconstitution in alphaGal-KO mice is impaired in the presence of high levels of antibodies against alphaGal.
Xenotransplantation 2003;10(1):24-40.
2002: Toh Han C; Spitzer Thomas R; Preffer Frederic; Alexander Stephen I; McAfee Steve; Dombkowski David; Clark Jeffrey S; Colby Christine; Saidman Susan; Sackstein Robert; Sykes Megan
Fluctuating lymphocyte chimerism, tolerance and anti-tumor response in a patient with refractory lymphoma receiving nonmyeloablative conditioning and a haploidentical related allogeneic bone marrow transplant.
Cytokines, cellular & molecular therapy 2002;7(2):43-7.
2002: Rodriguez-Barbosa Jose-Ignacio; Zhao Yong; Zhao Guiling; Ezquerra Angel; Sykes Megan
Murine CD4 T cells selected in a highly disparate xenogeneic porcine thymus graft do not show rapid decay in the absence of selecting MHC in the periphery.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):6697-710.
2002: Bühler Leo H; Spitzer Thomas R; Sykes Megan; Sachs David H; Delmonico Francis L; Tolkoff-Rubin Nina; Saidman Susan L; Sackstein Robert; McAfee Steven; Dey Bimalangshu; Colby Christine; Cosimi A Benedict
Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease.
Transplantation 2002;74(10):1405-9.
2002: Wekerle Thomas; Kurtz Josef; Bigenzahn Sinda; Takeuchi Yasuo; Sykes Megan
Mechanisms of transplant tolerance induction using costimulatory blockade.
Current opinion in immunology 2002;14(5):592-600.
2002: Mapara Markus Y; Kim Yong-Mi; Wang Sheng-Ping; Bronson Roderick; Sachs David H; Sykes Megan
Donor lymphocyte infusions mediate superior graft-versus-leukemia effects in mixed compared to fully allogeneic chimeras: a critical role for host antigen-presenting cells.
Blood 2002;100(5):1903-9.
2002: Heinz Matthew; Huang Christene A; Emery David W; Giovino Maria A; LeGuern Annie; Kurilla-Mahon Barbara; Theodore Pierre; Arn J Scott; Sykes Megan; Mulligan Richard; Down Julian D; Sachs David H; Goodell Margaret A
Use of CD9 expression to enrich for porcine hematopoietic progenitors.
Experimental hematology 2002;30(7):809-15.
2002: Theodore Pierre R; Simon Andre R; Warrens Anthony N; Sackstein Robert; Sykes Megan
Porcine mononuclear cells adhere to human fibronectin independently of very late antigen-5: implications for donor-specific tolerance induction in xenotransplantation.
Xenotransplantation 2002;9(4):277-89.
2002: Yang Yong-Guang; Qi Jin; Wang Min-Guang; Sykes Megan
Donor-derived interferon gamma separates graft-versus-leukemia effects and graft-versus-host disease induced by donor CD8 T cells.
Blood 2002;99(11):4207-15.
2002: Wekerle Thomas; Nikolic Boris; Pearson Denise A; Swenson Kirsten G; Sykes Megan
Minimal conditioning required in a murine model of T cell depletion, thymic irradiation and high-dose bone marrow transplantation for the induction of mixed chimerism and tolerance.
Transplant international : official journal of the European Society for Organ Transplantation 2002;15(5):248-53.
2002: Abe Masahiro; Qi Jin; Sykes Megan; Yang Yong-Guang
Mixed chimerism induces donor-specific T-cell tolerance across a highly disparate xenogeneic barrier.
Blood 2002;99(10):3823-9.
2002: Giovino Maria A; Down Julian D; Jackson John D; Sykes Megan; Monroy Rodney L; White-Scharf Mary E
Porcine hematopoiesis on primate stroma in long-term cultures: enhanced growth with neutralizing tumor necrosis factor-alpha and tumor growth factor-beta antibodies.
Transplantation 2002;73(5):723-31.
2002: Bühler L; Awwad M; Treter S; Chang Q; Basker M; Alwayn I P J; Teranishi K; Ericsson T; Moran K; Harper D; Kurilla-Mahon B; Huang C A; Sackstein R; Sykes M; White-Scharf M E; Sachs D H; Down J D; Cooper D K
Pig hematopoietic cell chimerism in baboons conditioned with a nonmyeloablative regimen and CD154 blockade.
Transplantation 2002;73(1):12-22.
2002: Abe Masahiro; Cheng Jane; Qi Jin; Glaser Roseann M; Thall Aron D; Sykes Megan; Yang Yong-Guang
Elimination of porcine hemopoietic cells by macrophages in mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(2):621-8.
2002: Preffer Frederic I; Dombkowski David; Sykes Megan; Scadden David; Yang Yong-Guang
Lineage-negative side-population (SP) cells with restricted hematopoietic capacity circulate in normal human adult blood: immunophenotypic and functional characterization.
Stem cells (Dayton, Ohio) 2002;20(5):417-27.
2001: Kurtz J; Ito H; Wekerle T; Shaffer J; Sykes M
Mechanisms involved in the establishment of tolerance through costimulatory blockade and BMT: lack of requirement for CD40L-mediated signaling for tolerance or deletion of donor-reactive CD4+ cells.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2001;1(4):339-49.
2001: Ohdan H; Swenson K G; Kitamura H; Yang Y G; Sykes M
Tolerization of Gal alpha 1,3Gal-reactive B cells in pre-sensitized alpha 1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism.
Xenotransplantation 2001;8(4):227-38.
2001: Zhao Y; Rodriguez-Barbosa J I; Swenson K; Zhao G; Arn J S; Sykes M
Highly disparate xenogeneic skin graft tolerance induction by fetal pig thymus in thymectomized mice: Conditioning requirements and the role of coimplantation of fetal pig liver.
Transplantation 2001;72(10):1608-15.
2001: Russell P S; Chase C M; Sykes M; Ito H; Shaffer J; Colvin R B
Tolerance, mixed chimerism, and chronic transplant arteriopathy.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5731-40.
2001: Rodriguez-Barbosa J I; Zhao Y; Barth R; Zhao G; Arn J S; Sachs D H; Sykes M
Enhanced CD4 reconstitution by grafting neonatal porcine tissue in alternative locations is associated with donor-specific tolerance and suppression of preexisting xenoreactive T cells.
Transplantation 2001;72(7):1223-31.
2001: Kawai T; Sogawa H; Koulmanda M; Smith R N; O'Neil J J; Wee S L; Boskovic S; Sykes M; Colvin R B; Sachs D H; Auchincloss H; Cosimi A B; C Ko D S
Long-term islet allograft function in the absence of chronic immunosuppression: a case report of a nonhuman primate previously made tolerant to a renal allograft from the same donor.
Transplantation 2001;72(2):351-4.
2001: Ohdan H; Yang Y G; Swenson K G; Kitamura H; Sykes M
T cell and B cell tolerance to GALalpha1,3GAL-expressing heart xenografts is achieved in alpha1,3-galactosyltransferase-deficient mice by nonmyeloablative induction of mixed chimerism.
Transplantation 2001;71(11):1532-42.
2001: Sykes M; Sachs D H
Mixed chimerism.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2001;356(1409):707-26.
2001: Sykes M
Mixed chimerism and transplant tolerance.
Immunity 2001;14(4):417-24.
2001: Ito H; Kurtz J; Shaffer J; Sykes M
CD4 T cell-mediated alloresistance to fully MHC-mismatched allogeneic bone marrow engraftment is dependent on CD40-CD40 ligand interactions, and lasting T cell tolerance is induced by bone marrow transplantation with initial blockade of this pathway.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(5):2970-81.
2001: Zhao Y; Rodriguez-Barbosa J I; Zhao G; Shaffer J; Arn J S; Sykes M
Maturation and function of mouse T-cells with a transgenic TCR positively selected by highly disparate xenogeneic porcine MHC.
Cellular and molecular biology (Noisy-le-Grand, France) 2001;47(1):217-28.
2001: Wu A; Yamada K; Awwad M; Kitamura H; Wain J; Neville D M; Cooper D K; Sykes M; Sachs D H
Effects of xenogeneic thymic transplantation in baboons.
Transplantation proceedings 2001;33(1-2):766.
2001: Nikolic B; Zhao G; Sykes M
A role for donor-derived B cells but not T cells in the maintenance of mixed hematopoietic chimerism.
Transplantation proceedings 2001;33(1-2):182.
2001: Leykin I; Nikolic B; Sykes M
Mixed bone marrow chimerism as a treatment for autoimmune diabetes.
Transplantation proceedings 2001;33(1-2):120.
2001: Wekerle T; Kurtz J; Sayegh M; Ito H; Wells A; Bensinger S; Shaffer J; Turka L; Sykes M
Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2311-6.
2001: Nikolic B; Cooke D T; Zhao G; Sykes M
Both gamma delta T cells and NK cells inhibit the engraftment of xenogeneic rat bone marrow cells and the induction of xenograft tolerance in mice.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(2):1398-404.
2001: Mapara M Y; Pelot M; Zhao G; Swenson K; Pearson D; Sykes M
Induction of stable long-term mixed hematopoietic chimerism following nonmyeloablative conditioning with T cell-depleting antibodies, cyclophosphamide, and thymic irradiation leads to donor-specific in vitro and in vivo tolerance.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2001;7(12):646-55.
2001: Dey B R; McAfee S; Sackstein R; Colby C; Saidman S; Weymouth D; Poliquin C; Vanderklish J; Sachs D H; Sykes M; Spitzer T R
Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2001;7(11):604-12.
2001: Nikolic B; Khan A; Sykes M
Induction of tolerance by mixed chimerism with nonmyeloblative host conditioning: the importance of overcoming intrathymic alloresistance.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2001;7(3):144-53.
2001: Wekerle T; Sykes M
Mixed chimerism and transplantation tolerance.
Annual review of medicine 2001;52():353-70.
2000: Ohdan H; Swenson K G; Kruger Gray H S; Yang Y G; Xu Y; Thall A D; Sykes M
Mac-1-negative B-1b phenotype of natural antibody-producing cells, including those responding to Gal alpha 1,3Gal epitopes in alpha 1,3-galactosyltransferase-deficient mice.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5518-29.
2000: Bühler L; Awwad M; Basker M; Gojo S; Thall A; Down J D; Sykes M; Andrews D; Sackstein R; White-Scharf M E; Sachs D H; Cooper D K
A nonmyeloablative regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboons.
Transplantation proceedings 2000;32(5):1100.
2000: Wu A; Yamada K; Awwad M; Shimizu A; Watts A; Murphy M; Gojo S; Neville D; Cooper D K; Sykes M; Sachs D H
Experience with porcine thymic transplantation in baboons.
Transplantation proceedings 2000;32(5):1048.
2000: Abe M; Chen A M; Qi J; Sachs D H; Sykes M; Yang Y
Porcine stem cell factor facilitates long-lasting porcine hematopoietic engraftment in murine recipients.
Transplantation proceedings 2000;32(5):1047.
2000: Nikolic B; Zhao G; Swenson K; Sykes M
A novel application of cyclosporine A in nonmyeloablative pretransplant host conditioning for allogeneic BMT.
Blood 2000;96(3):1166-72.
2000: Chen A M; Zhou Y; Swenson K; Sachs D H; Sykes M; Yang Y G
Porcine stem cell engraftment and seeding of murine thymus with class II+ cells in mice expressing porcine cytokines: toward tolerance induction across discordant xenogeneic barriers.
Transplantation 2000;69(12):2484-90.
2000: Bühler L; Awwad M; Basker M; Gojo S; Watts A; Treter S; Nash K; Oravec G; Chang Q; Thall A; Down J D; Sykes M; Andrews D; Sackstein R; White-Scharf M E; Sachs D H; Cooper D K
High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response.
Transplantation 2000;69(11):2296-304.
2000: Fuchimoto Y; Huang C A; Yamada K; Shimizu A; Kitamura H; Colvin R B; Ferrara V; Murphy M C; Sykes M; White-Scharf M; Neville D M; Sachs D H
Mixed chimerism and tolerance without whole body irradiation in a large animal model.
The Journal of clinical investigation 2000;105(12):1779-89.
2000: Zhao Y; Swenson K; Wekerle T; Rodriguez-Barbosa J I; Arn J S; Sykes M
The critical role of mouse CD4+ cells in the rejection of highly disparate xenogeneic pig thymus grafts.
Xenotransplantation 2000;7(2):129-37.
2000: Nikolic B; Lee S; Bronson R T; Grusby M J; Sykes M
Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets.
The Journal of clinical investigation 2000;105(9):1289-98.
2000: Zhao Y; Rodriguez-Barbosa J I; Swenson K; Barth R N; Shimizu A; Arn J S; Sachs D H; Sykes M
The induction of specific pig skin graft tolerance by grafting with neonatal pig thymus in thymectomized mice.
Transplantation 2000;69(7):1447-51.
2000: Wekerle T; Kurtz J; Ito H; Ronquillo J V; Dong V; Zhao G; Shaffer J; Sayegh M H; Sykes M
Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatment.
Nature medicine 2000;6(4):464-9.
2000: Ohdan H; Yang Y G; Swenson K G; Thall A D; Sykes M
In vivo T-cell depletion enhances production of anti-GALalpha1,3GAL natural antibodies in alpha1,3-galactosyltransferase-deficient mice.
Transplantation 2000;69(5):910-3.
2000: Cheng T; Rodrigues N; Shen H; Yang Y; Dombkowski D; Sykes M; Scadden D T
Hematopoietic stem cell quiescence maintained by p21cip1/waf1.
Science (New York, N.Y.) 2000;287(5459):1804-8.
2000: Yang Y G; Chen A M; Garrett L J; Sergio J J; Theodore P; Awwad M; VerHalen J; Bodine D M; Sachs D H; Sykes M
Development and analysis of transgenic mice expressing porcine hematopoietic cytokines: a model for achieving durable porcine hematopoietic chimerism across an extensive xenogeneic barrier.
Xenotransplantation 2000;7(1):58-64.
2000: Warrens A N; Simon A R; Theodore P R; Sachs D H; Sykes M
Cross-species compatibility of intercellular adhesion molecule-1 (CD54) with its ligands.
Transplantation 2000;69(3):394-9.
2000: Kozlowski T; Sablinski T; Basker M; Kitamura H; Spitzer T R; Fishman J; Sykes M; Cooper D K; Sachs D H
Decreased graft-versus-host disease after haplotype mismatched bone marrow allografts in miniature swine following interleukin-2 treatment.
Bone marrow transplantation 2000;25(1):47-52.
2000: Yang Y G; Chen A M; Sergio J J; Zhou Y; Sykes M
Role of antibody-independent complement activation in rejection of porcine bone marrow cells in mice.
Transplantation 2000;69(1):163-5.
2000: Spitzer T R; McAfee S; Sackstein R; Colby C; Toh H C; Multani P; Saidman S; Weyouth D W; Preffer F; Poliquin C; Foley A; Cox B; Andrews D; Sachs D H; Sykes M
Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 2000;6(3A):309-20.
1999: Wekerle T; Sayegh M H; Ito H; Hill J; Chandraker A; Pearson D A; Swenson K G; Zhao G; Sykes M
Anti-CD154 or CTLA4Ig obviates the need for thymic irradiation in a non-myeloablative conditioning regimen for the induction of mixed hematopoietic chimerism and tolerance.
Transplantation 1999;68(9):1348-55.
1999: Haller G W; Esnaola N; Yamada K; Wu A; Shimizu A; Hansen A; Ferrara V R; Allison K S; Colvin R B; Sykes M; Sachs D H
Thymic transplantation across an MHC class I barrier in swine.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(7):3785-92.
1999: Manilay J O; Waneck G L; Sykes M
Levels of Ly-49 receptor expression are determined by the frequency of interactions with MHC ligands: evidence against receptor calibration to a "useful" level.
Journal of immunology (Baltimore, Md. : 1950) 1999;163(5):2628-33.
1999: Spitzer T R; Delmonico F; Tolkoff-Rubin N; McAfee S; Sackstein R; Saidman S; Colby C; Sykes M; Sachs D H; Cosimi A B
Combined histocompatibility leukocyte antigen-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: the induction of allograft tolerance through mixed lymphohematopoietic chimerism.
Transplantation 1999;68(4):480-4.
1999: Wekerle T; Sykes M
Mixed chimerism as an approach for the induction of transplantation tolerance.
Transplantation 1999;68(4):459-67.
1999: Ohdan H; Yang Y G; Shimizu A; Swenson K G; Sykes M
Mixed chimerism induced without lethal conditioning prevents T cell- and anti-Gal alpha 1,3Gal-mediated graft rejection.
The Journal of clinical investigation 1999;104(3):281-90.
1999: Dey B; Yang Y G; Preffer F; Shimizu A; Swenson K; Dombkowski D; Sykes M
The fate of donor T-cell receptor transgenic T cells with known host antigen specificity in a graft-versus-host disease model.
Transplantation 1999;68(1):141-9.
1999: Simon A R; Warrens A N; Sykes M
Efficacy of adhesive interactions in pig-to-human xenotransplantation.
Immunology today 1999;20(7):323-30.
1999: Warrens A N; Simon A R; Theodore P R; Sykes M
Human-porcine receptor-ligand compatibility within the immune system: relevance for xenotransplantation.
Xenotransplantation 1999;6(2):75-8.
1999: Yang Y G; Sykes M
The role of interleukin-12 in preserving the graft-versus-leukemia effect of allogeneic CD8 T cells independently of GVHD.
Leukemia & lymphoma 1999;33(5-6):409-20.
1999: Nikolic B; Gardner J P; Scadden D T; Arn J S; Sachs D H; Sykes M
Normal development in porcine thymus grafts and specific tolerance of human T cells to porcine donor MHC.
Journal of immunology (Baltimore, Md. : 1950) 1999;162(6):3402-7.
1999: Wu A; Esnaola N F; Yamada K; Awwad M; Shimizu A; Huang C; Wain J; Zhao Y; Neville D M; Cooper D K; Sykes M; Sachs D H
Xenogeneic thymic transplantation in a pig-to-nonhuman primate model.
Transplantation proceedings 1999;31(1-2):957.
1999: Ohdan H; Yang Y G; Sykes M
Reduction of anti-Gal alpha 1-3Gal natural antibodies in sera of alpha 1,3-galactosyltransferase-deficient mice receiving Gal-positive bone marrow transplantation.
Transplantation proceedings 1999;31(1-2):945-6.
1999: Nikolic B; Sykes M
Porcine thymus supports development of human T cells that are tolerant to porcine xenoantigens.
Transplantation proceedings 1999;31(1-2):924.
1999: Cooke D T; Nikolic B; Sykes M
The role of atypical T cells and NK cells in inhibiting primary engraftment of xenogeneic donor rat bone marrow cells.
Transplantation proceedings 1999;31(1-2):683.
1999: Wekerle T; Sayegh M H; Chandraker A; Swenson K G; Zhao Y; Sykes M
Role of peripheral clonal deletion in tolerance induction with bone marrow transplantation and costimulatory blockade.
Transplantation proceedings 1999;31(1-2):680.
1999: Sykes M; Pearson D A; Taylor P A; Szot G L; Goldman S J; Blazar B R
Dose and timing of interleukin (IL)-12 and timing and type of total-body irradiation: effects on graft-vs.-host disease inhibition and toxicity of exogenous IL-12 in murine bone marrow transplant recipients.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1999;5(5):277-84.
1999: Pelot M R; Pearson D A; Swenson K; Zhao G; Sachs J; Yang Y G; Sykes M
Lymphohematopoietic graft-vs.-host reactions can be induced without graft-vs.-host disease in murine mixed chimeras established with a cyclophosphamide-based nonmyeloablative conditioning regimen.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1999;5(3):133-43.
1998: Manilay J O; Waneck G L; Sykes M
Altered expression of Ly-49 receptors on NK cells developing in mixed allogeneic bone marrow chimeras.
International immunology 1998;10(12):1943-55.
1998: Sykes M; Ohdan H; Manilay J O; Wekerle T; Yang Y G
Hematopoietic chimerism and tolerance of T cells, B cells, and NK cells.
Transplantation proceedings 1998;30(8):4020.
1998: Yang Y G; Dey B R; Sergio J J; Pearson D A; Sykes M
Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12.
The Journal of clinical investigation 1998;102(12):2126-35.
1998: Manilay J O; Sykes M
Natural killer cells and their role in graft rejection.
Current opinion in immunology 1998;10(5):532-8.
1998: Dey B; Sykes M; Spitzer T R
Outcomes of recipients of both bone marrow and solid organ transplants. A review.
Medicine 1998;77(5):355-69.
1998: Wekerle T; Sachs D H; Sykes M
Mixed chimerism for the induction of tolerance: potential applicability in clinical composite tissue grafting.
Transplantation proceedings 1998;30(6):2708-10.
1998: Simon A R; Warrens A N; Yazzie N P; Seebach J D; Sachs D H; Sykes M
Cross-species interaction of porcine and human integrins with their respective ligands: implications for xenogeneic tolerance induction.
Transplantation 1998;66(3):385-94.
1998: Zhao Y; Swenson K; Sergio J J; Sykes M
Pig MHC mediates positive selection of mouse CD4+ T cells with a mouse MHC-restricted TCR in pig thymus grafts.
Journal of immunology (Baltimore, Md. : 1950) 1998;161(3):1320-6.
1998: Warrens A N; Simon A R; Theodore P R; Sachs D H; Sykes M
Function of porcine adhesion molecules in a human marrow microenvironment.
Transplantation 1998;66(2):252-9.
1998: Manilay J O; Pearson D A; Sergio J J; Swenson K G; Sykes M
Intrathymic deletion of alloreactive T cells in mixed bone marrow chimeras prepared with a nonmyeloablative conditioning regimen.
Transplantation 1998;66(1):96-102.
1998: Yang Y G; deGoma E; Barth R; Sergio J J; Sykes M
B-cell reconstitution and xenoreactive anti-pig natural antibody production in severe combined immunodeficient mice reconstituted with immunocompetent B cells from varying sources.
Transplantation 1998;66(1):89-95.
1998: Wekerle T; Sayegh M H; Hill J; Zhao Y; Chandraker A; Swenson K G; Zhao G; Sykes M
Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell tolerance.
The Journal of experimental medicine 1998;187(12):2037-44.
1998: Sykes M; Szot G L; Swenson K; Pearson D A; Wekerle T
Separate regulation of peripheral hematopoietic and thymic engraftment.
Experimental hematology 1998;26(6):457-65.
1998: Nikolic B; Lei H; Pearson D A; Sergio J J; Swenson K G; Sykes M
Role of intrathymic rat class II+ cells in maintaining deletional tolerance in xenogeneic rat-->mouse bone marrow chimeras.
Transplantation 1998;65(9):1216-24.
1998: Dey B R; Yang Y G; Szot G L; Pearson D A; Sykes M
Interleukin-12 inhibits graft-versus-host disease through an Fas-mediated mechanism associated with alterations in donor T-cell activation and expansion.
Blood 1998;91(9):3315-22.
1998: Yang Y G; deGoma E; Ohdan H; Bracy J L; Xu Y; Iacomini J; Thall A D; Sykes M
Tolerization of anti-Galalpha1-3Gal natural antibody-forming B cells by induction of mixed chimerism.
The Journal of experimental medicine 1998;187(8):1335-42.
1998: Zhao Y; Barth R N; Swenson K; Pearson D A; Sykes M
Functionally and phenotypically mature mouse CD8+ T cells develop in porcine thymus grafts in mice.
Xenotransplantation 1998;5(1):99-104.
1997: Colby C; Sykes M; Sachs D H; Spitzer T R
Cellular modulation of acute graft-vs.-host disease.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation 1997;3(6):287-93.
1997: Yang Y G; Sergio J J; Pearson D A; Szot G L; Shimizu A; Sykes M
Interleukin-12 preserves the graft-versus-leukemia effect of allogeneic CD8 T cells while inhibiting CD4-dependent graft-versus-host disease in mice.
Blood 1997;90(11):4651-60.
1997: Yang Y G; Dey B; Sergio J J; Sykes M
Interleukin-12 prevents severe acute graft-versus-host disease (GVHD) and GVHD-associated immune dysfunction in a fully major histocompatibility complex haplotype-mismatched murine bone marrow transplantation model.
Transplantation 1997;64(9):1343-52.
1997: Sykes M; Zhao Y; Yang Y G
Tolerance induction for xenotransplantation.
World journal of surgery 1997;21(9):932-8.
1997: Nikolic B; Sykes M
Bone marrow chimerism and transplantation tolerance.
Current opinion in immunology 1997;9(5):634-40.
1997: Zhao Y; Sergio J J; Swenson K; Arn J S; Sachs D H; Sykes M
Positive and negative selection of functional mouse CD4 cells by porcine MHC in pig thymus grafts.
Journal of immunology (Baltimore, Md. : 1950) 1997;159(5):2100-7.
1997: Zhao Y; Sykes M
Resistance to monoclonal antibody-induced CD8+ T-cell depletion in thymectomized MHC class II-deficient mice.
Transplantation 1997;64(3):489-94.
1997: Sykes M; Szot G L; Swenson K A; Pearson D A
Induction of high levels of allogeneic hematopoietic reconstitution and donor-specific tolerance without myelosuppressive conditioning.
Nature medicine 1997;3(7):783-7.
1997: Mayfield R S; Hayashi H; Sawada T; Bergen K; LeGuern C; Sykes M; Sachs D H; Iacomini J
The mechanism of specific prolongation of class I-mismatched skin grafts induced by retroviral gene therapy.
European journal of immunology 1997;27(5):1177-81.
1997: Zhao Y; Sergio J J; Pearson D A; Szot G L; Arn J S; Sachs D H; Sykes M
Repopulation of mouse CD4 cells in BALB/c nude mice receiving fetal pig thymus/liver grafts.
Transplantation proceedings 1997;29(1-2):1228-9.
1997: Hayashi H; Mayfield R S; Sawada T; Germana S; Sykes M; Iacomini J; Sachs D H; LeGuern C
Role of the thymus in donor specific hyporesponsiveness induced by retroviral transduction of bone marrow using an MHC class I gene.
Transplantation proceedings 1997;29(1-2):1133.
1997: Yasumoto A; Yamada K; Sablinski T; LeGuern C; Sykes M; Sachs D H
Mechanism of tolerance following class II gene transduction of autologous swine bone marrow.
Transplantation proceedings 1997;29(1-2):1132.
1997: Zhao Y; Fishman J A; Sergio J J; Oliveros J L; Pearson D A; Szot G L; Wilkinson R A; Arn J S; Sachs D H; Sykes M
Immune restoration by fetal pig thymus grafts in T cell-depleted, thymectomized mice.
Journal of immunology (Baltimore, Md. : 1950) 1997;158(4):1641-9.
1997: Khan A; Sergio J J; Zhao Y; Pearson D A; Sachs D H; Sykes M
Discordant xenogeneic neonatal thymic transplantation can induce donor-specific tolerance.
Transplantation 1997;63(1):124-31.
1997: Nikolic B; Sykes M
Mixed hematopoietic chimerism and transplantation tolerance.
Immunologic research 1997;16(3):217-28.
1996: Nikolic B; Sykes M
Clonal deletion as a mechanism of transplantation tolerance.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 1996;15(12):1171-8.
1996: Zhao Y; Swenson K; Sergio J J; Arn J S; Sachs D H; Sykes M
Skin graft tolerance across a discordant xenogeneic barrier.
Nature medicine 1996;2(11):1211-6.
1996: Sykes M
Chimerism and central tolerance.
Current opinion in immunology 1996;8(5):694-703.
1996: Hayashi H; LeGuern C; Sachs D H; Sykes M
Alloresistance to K locus class I-mismatched bone marrow engraftment is mediated entirely by CD4+ and CD8+ T cells.
Bone marrow transplantation 1996;18(2):285-92.
1996: Khan A; Tomita Y; Sykes M
Thymic dependence of loss of tolerance in mixed allogeneic bone marrow chimeras after depletion of donor antigen. Peripheral mechanisms do not contribute to maintenance of tolerance.
Transplantation 1996;62(3):380-7.
1996: Sykes M
Immunobiology of transplantation.
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1996;10(7):721-30.
1996: Gritsch H A; Sykes M
Hematopoietic competition limits xenogenic myeloid reconstitution in SCID mice.
Transplantation proceedings 1996;28(2):708.
1996: Yang Y G; Glaser R M; Monroy R; Swenson K; Sykes M
Enhanced porcine hematopoiesis in mice receiving donor-specific interleukin-3.
Transplantation proceedings 1996;28(2):655.
1996: Hayashi H; LeGuern C; Sachs D H; Sykes M
Long-term engraftment of precultured post-5-fluorouracil allogeneic marrow in mice conditioned with a nonmyeloablative regimen: relevance for a gene therapy approach to tolerance induction.
Transplant immunology 1996;4(1):86-90.
1996: Tomita Y; Khan A; Sykes M
Mechanism by which additional monoclonal antibody (mAB) injections overcome the requirement for thymic irradiation to achieve mixed chimerism in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation.
Transplantation 1996;61(3):477-85.
1996: Tomita Y; Sachs D H; Khan A; Sykes M
Additional monoclonal antibody (mAB) injections can replace thymic irradiation to allow induction of mixed chimerism and tolerance in mice receiving bone marrow transplantation after conditioning with anti-T cell mABs and 3-Gy whole body irradiation.
Transplantation 1996;61(3):469-77.
1996: Lee L A; Sergio J J; Sykes M
Natural killer cells weakly resist engraftment of allogeneic, long-term, multilineage-repopulating hematopoietic stem cells.
Transplantation 1996;61(1):125-32.
1996: Szebeni J; Sykes M
CAG repeat mutation in the mouse IL-2 gene enables concurrent assessment of T- and B-cell-specific gene expression by northern analysis.
Experimental and clinical immunogenetics 1996;13(2):117-9.
1995: Wang M G; Szebeni J; Pearson D A; Szot G L; Sykes M
Inhibition of graft-versus-host disease by interleukin-2 treatment is associated with altered cytokine production by expanded graft-versus-host-reactive CD4+ helper cells.
Transplantation 1995;60(5):481-90.
1995: Sykes M; Szot G L; Nguyen P L; Pearson D A
Interleukin-12 inhibits murine graft-versus-host disease.
Blood 1995;86(6):2429-38.
1995: Sachs D H; Sykes M; Greenstein J L; Cosimi A B
Tolerance and xenograft survival.
Nature medicine 1995;1(9):969.
1995: Sykes M; Pearson D A; Szot G L
IL-2-induced GVHD protection is not inhibited by cyclosporine and is maximal when IL-2 is given over a 25 h period beginning on the day following bone marrow transplantation.
Bone marrow transplantation 1995;15(3):395-9.
1995: Hayashi H; Lee R S; Germana S; Fraser C; Sykes M; Sachs D H; LeGuern C
Retroviral vectors for long-term expression of allogeneic major histocompatibility complex transduced into syngeneic bone marrow cells.
Transplantation proceedings 1995;27(1):178-9.
1995: Fraser C C; Sykes M; Lee R S; Sachs D H; LeGuern C
Specific unresponsiveness to a retrovirally-transferred class I antigen is controlled through the helper pathway.
Journal of immunology (Baltimore, Md. : 1950) 1995;154(4):1587-95.
1995: Kawai T; Cosimi A B; Colvin R B; Powelson J; Eason J; Kozlowski T; Sykes M; Monroy R; Tanaka M; Sachs D H
Mixed allogeneic chimerism and renal allograft tolerance in cynomolgus monkeys.
Transplantation 1995;59(2):256-62.
1994: Szebeni J; Wang M G; Pearson D A; Szot G L; Sykes M
IL-2 inhibits early increases in serum gamma interferon levels associated with graft-versus-host-disease.
Transplantation 1994;58(12):1385-93.
1994: Lee L A; Gritsch H A; Sergio J J; Arn J S; Glaser R M; Sablinski T; Sachs D H; Sykes M
Specific tolerance across a discordant xenogeneic transplantation barrier.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(23):10864-7.
1994: Tomita Y; Khan A; Sykes M
Role of intrathymic clonal deletion and peripheral anergy in transplantation tolerance induced by bone marrow transplantation in mice conditioned with a nonmyeloablative regimen.
Journal of immunology (Baltimore, Md. : 1950) 1994;153(3):1087-98.
1994: Tanaka M; Latinne D; Gianello P; Sablinski T; Lorf T; Bailin M; Nickeleit V; Colvin R; Lebowitz E; Sykes M
Xenotransplantation from pig to cynomolgus monkey: the potential for overcoming xenograft rejection through induction of chimerism.
Transplantation proceedings 1994;26(3):1326-7.
1994: Emery D W; Sykes M; Sachs D H; LeGuern C
Mixed swine/human long-term bone marrow cultures.
Transplantation proceedings 1994;26(3):1313-4.
1994: Lee L A; Gritsch H A; Arn J S; Emery D W; Glaser R M; Sablinski T; Sachs D H; Sykes M
Induction of tolerance to pig antigens in mice grafted with fetal pig thymus/liver grafts.
Transplantation proceedings 1994;26(3):1300-1.
1994: Lee L A; Sergio J J; Sachs D H; Sykes M
Mechanism of tolerance in mixed xenogeneic chimeras prepared with a nonmyeloablative conditioning regimen.
Transplantation proceedings 1994;26(3):1197-8.
1994: Sykes M; Harty M W; Szot G L; Pearson D A
Interleukin-2 inhibits graft-versus-host disease-promoting activity of CD4+ cells while preserving CD4- and CD8-mediated graft-versus-leukemia effects.
Blood 1994;83(9):2560-9.
1994: Gritsch H A; Glaser R M; Emery D W; Lee L A; Smith C V; Sablinski T; Arn J S; Sachs D H; Sykes M
The importance of nonimmune factors in reconstitution by discordant xenogeneic hematopoietic cells.
Transplantation 1994;57(6):906-17.
1994: Tomita Y; Sachs D H; Sykes M
Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow.
Blood 1994;83(4):939-48.
1994: Latinne D; Vitiello D M; Sachs D H; Sykes M
Tolerance to discordant xenografts. I. Sharing of human natural antibody determinants on miniature swine bone marrow cells and endothelial cells.
Transplantation 1994;57(2):238-45.
1994: Sykes M; Harty M W; Pearson D A
Strain dependence of interleukin-2-induced graft-versus-host disease protection: evidence that interleukin-2 inhibits selected CD4 functions.
Journal of immunotherapy with emphasis on tumor immunology : official journal of the Society for Biological Therapy 1994;15(1):11-21.
1993: Sykes M
Novel approaches to the control of graft versus host disease.
Current opinion in immunology 1993;5(5):774-81.
1993: Sykes M; Harty M W; Karlhofer F M; Pearson D A; Szot G; Yokoyama W
Hematopoietic cells and radioresistant host elements influence natural killer cell differentiation.
The Journal of experimental medicine 1993;178(1):223-9.
1993: Sachs D H; Smith C V; Emery D W; LeGuern C; Bodine D; Nienhuis A; Sykes M
Induction of specific tolerance to MHC-disparate allografts through genetic engineering.
Experimental nephrology 1993;1(2):128-33.
1993: Lee L A; Sachs D H; Sykes M
Effect of natural killer cell depletion on long-term multilineage allogeneic bone marrow engraftment.
Transplantation proceedings 1993;25(1 Pt 2):1246-7.
1993: Sykes M; Abraham V S; Harty M W; Pearson D A
Selective inhibition of CD4 graft-versus-host activity in IL-2-treated mice.
Transplantation proceedings 1993;25(1 Pt 2):1225-6.
1993: Sachs D H; Bodine D M; Moulton A D; Pearson D A; Nienhuis A W; Sykes M
Tolerance induction using autologous bone marrow modified with an allogeneic class I MHC gene.
Transplantation proceedings 1993;25(1 Pt 1):348-9.
1993: Latinne D; Gianello P; Smith C V; Nickeleit V; Kawai T; Beadle M; Haug C; Sykes M; Lebowitz E; Bazin H
Xenotransplantation from pig to cynomolgus monkey: approach toward tolerance induction.
Transplantation proceedings 1993;25(1 Pt 1):336-8.
1993: Sykes M; Sachs D H; Nienhuis A W; Pearson D A; Moulton A D; Bodine D M
Specific prolongation of skin graft survival following retroviral transduction of bone marrow with an allogeneic major histocompatibility complex gene.
Transplantation 1993;55(1):197-202.
1993: Sykes M; Abraham V S; Harty M W; Pearson D A
IL-2 reduces graft-versus-host disease and preserves a graft-versus-leukemia effect by selectively inhibiting CD4+ T cell activity.
Journal of immunology (Baltimore, Md. : 1950) 1993;150(1):197-205.
1992: Sykes M; Pearson D A
Alloengraftment in IL-2-treated mice.
Bone marrow transplantation 1992;10(2):157-63.
1992: Abraham V S; Sachs D H; Sykes M
Mechanism of protection from graft-versus-host disease mortality by IL-2. III. Early reductions in donor T cell subsets and expansion of a CD3+CD4-CD8- cell population.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(12):3746-52.
1992: Aksentijevich I; Sachs D H; Sykes M
Humoral tolerance in xenogeneic BMT recipients conditioned by a nonmyeloablative regimen.
Transplantation 1992;53(5):1108-14.
1992: Sykes M; Abraham V S
The mechanism of IL-2-mediated protection against GVHD in mice. II. Protection occurs independently of NK/LAK cells.
Transplantation 1992;53(5):1063-70.
1992: Sykes M; Sachs D H; Aksentijevich I
Effect of natural antibody on xenogeneic bone marrow engraftment.
Transplantation proceedings 1992;24(2):497-8.
1992: Nakajima K; Smith C V; Mixon A; Sykes M; Guzzetta P C; Spitzer T R; Eckhaus M A; Sachs D H
In vitro and in vivo effects of recombinant human interleukin-2 in naive miniature swine.
Journal of immunotherapy : official journal of the Society for Biological Therapy 1992;11(3):169-75.
1992: Sykes M
Dissociating graft-vs-host disease from the graft-vs-leukemia effect of allogeneic T cells: the potential role of IL-2.
Bone marrow transplantation 1992;10 Suppl 1():1-4.

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