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Fraser Symmans

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Disorders

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Chemicals & Drugs

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Oligonucleotide Array Sequence Analysis

Physiology

Gene Expression Regulation, Neoplastic

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Ke-Da Yu; Ming Zhan; Rui Zhu; Xi Chen; Brian D Lehmann; Andreas Makris; Ingrid Mayer; Jennifer A Pietenpol; Angel A Rodriguez; Zhi-Ming Shao; W Fraser Symmans; Stephen Wong; Wei Yang; Jenny C Chang
Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer.
Borbala Szekely; Anna-Maria Tokes; Takayuki Iwamoto; Janina Kulka; Junji Matsuoka; Yuan Qi; Charles Swanton; W Fraser Symmans; A Marcell Szasz; Lajos Pusztai
A 3-gene proliferation score (TOP-FOX-67) can re-classify histological grade-2, ER-positive breast cancers into low- and high-risk prognostic categories.
H A Azim; Suzette Delaloge; M Filipits; Sherene Loi; S Michiels; M Namer; P Neven; W Fraser Symmans; A Thompson; F Zagouri; F André; C Swanton
Utility of prognostic genomic tests in breast cancer practice: The IMPAKT 2012 Working Group Consensus Statement.

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2013: Ke-Da Yu; Ming Zhan; Rui Zhu; Xi Chen; Brian D Lehmann; Andreas Makris; Ingrid Mayer; Jennifer A Pietenpol; Angel A Rodriguez; Zhi-Ming Shao; W Fraser Symmans; Stephen Wong; Wei Yang; Jenny C Chang
Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(10):2723-33.
2013: Borbala Szekely; Anna-Maria Tokes; Takayuki Iwamoto; Janina Kulka; Junji Matsuoka; Yuan Qi; Charles Swanton; W Fraser Symmans; A Marcell Szasz; Lajos Pusztai
A 3-gene proliferation score (TOP-FOX-67) can re-classify histological grade-2, ER-positive breast cancers into low- and high-risk prognostic categories.
Breast cancer research and treatment 2013;138(3):691-8.
2013: H A Azim; Suzette Delaloge; M Filipits; Sherene Loi; S Michiels; M Namer; P Neven; W Fraser Symmans; A Thompson; F Zagouri; F André; C Swanton
Utility of prognostic genomic tests in breast cancer practice: The IMPAKT 2012 Working Group Consensus Statement.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2013;24(3):647-54.
2013: Cathy M Kelly; W Fraser Symmans; Eleni Andreopoulou; Giampaolo Bianchini
Breast cancer genomics: challenges in interpretation and application.
The oncologist 2013;18(4):e11-2.
2012: Libero Santarpia; Katherine Stemke-Hale; W Fraser Symmans; Vicente Valero; Tatiana Vidaurre; Bailiang Wang; Elliana J Young; Yuan Qi; Daniel J Booser; Giulia Bottai; Angelo Di Leo; Henry Gomez; Ana M Gonzalez-Angulo; Beth Hellerstedt; Frankie A Holmes; Gabriel N Hortobagyi; Joyce O'Shaughnessy; John Pippen; Lajos Pusztai
Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers.
Breast cancer research and treatment 2012;134(1):333-43.
2012: Manfred Kaufmann; Cornelia Liedtke; Elefhterios P Mamounas; Davide Mauri; Roman Rouzier; Eugen Ruckhaeberle; Vladimir Semiglazov; W Fraser Symmans; Andrew Tutt; Gunter von Minckwitz; David Cameron; Lisa A Carey; Massimo Cristofanilli; Carsten Denkert; Wolfgang Eiermann; Michael Gnant; Jay R Harris; Thomas Karn; Lajos Pusztai
Recommendations from an international consensus conference on the current status and future of neoadjuvant systemic therapy in primary breast cancer.
Annals of surgical oncology 2012;19(5):1508-16.
2012: W Fraser Symmans
A perspective on genomic tests for breast cancer: the need for progress.
Oncology (Williston Park, N.Y.) 2012;26(4):364-5, 369.
2012: Takayuki Iwamoto; Kimberly Koenig; Junji Matsuoka; James L Murray; Daniel J Booser; Francisco J Esteva; Christos Hatzis; Gabriel N Hortobagyi; Yuan Qi; Weiwei Shi; W Fraser Symmans; Naoto T Ueno; Vicente Valero; Elliana J Yang; Jie Zhang; Lajos Pusztai
Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that are 1% to 10% ER-positive by immunohistochemistry.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2012;30(7):729-34.
2012: Ana M Gonzalez-Angulo; Gabriel N Hortobagyi; Takayuki Iwamoto; Shuying Liu; Funda Meric-Bernstam; Gordon B Mills; Huiqin Chen; Kim-Anh Do; W Fraser Symmans; Lajos Pusztai
Gene expression, molecular class changes, and pathway analysis after neoadjuvant systemic therapy for breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(4):1109-19.
2012: Kui Shen; Nan Song; W Fraser Symmans; Chunqiao Tian; Michael J Gabrin; Youngchul Kim; Lajos Pusztai; Shara D Rice; Jae K Lee
A systematic evaluation of multi-gene predictors for the pathological response of breast cancer patients to chemotherapy.
PloS one 2012;7(11):e49529.
2012: J Michael Dixon; Mark Verrill; Victoria Wilson; W Fraser Symmans
HER2 testing in patients with breast cancer.
BMJ (Clinical research ed.) 2012;344():e3958.
2011: Chang Chang; Youping Deng; Jennifer Fostel; Lajos Pusztai; W Fraser Symmans; Weida Tong; Junwei Wang; Chen Zhao; Pierre R Bushel; Tieliu Shi
Maximizing biomarker discovery by minimizing gene signatures.
BMC genomics 2011;12 Suppl 5():S6.
2011: Chen Zhao; W Fraser Symmans; Weida Tong; Youping Deng; André Oberthuer; Lajos Pusztai; John D Shaughnessy; Leming Shi; Tieliu Shi
Maximum predictive power of the microarray-based models for clinical outcomes is limited by correlation between endpoint and gene expression profile.
BMC genomics 2011;12 Suppl 5():S3.
2011: Takayuki Iwamoto; Sang Bae Kim; Ju Seog Lee; Junji Matsuoka; Giampaolo Bianchini; Gabriel N Hortobagyi; Rebekah E Hubbard; W Fraser Symmans; Elliana Young; Lajos Pusztai
First generation prognostic gene signatures for breast cancer predict both survival and chemotherapy sensitivity and identify overlapping patient populations.
Breast cancer research and treatment 2011;130(1):155-64.
2011: Sherene Loi; Lajos Pusztai; W Fraser Symmans; Laura Van't Veer; Giuseppe Viale; Joanne Zujewski; John M S Bartlett; Philippe Bedard; Carsten Denkert; Laura J Esserman; John F Forbes; Debora Fumagalli; Brian Leyland-Jones
Proposals for uniform collection of biospecimens from neoadjuvant breast cancer clinical trials: timing and specimen types.
The lancet oncology 2011;12(12):1162-8.
2011: Christos Hatzis; Lajos Pusztai; Vicente Valero; Daniel J Booser; Laura Esserman; Ana Lluch; Tatiana Vidaurre; Frankie Holmes; Eduardo Souchon; Hongkun Wang; Miguel Martin; José Cotrina; Henry Gomez; Rebekah Hubbard; J Ignacio Chacón; Jaime Ferrer-Lozano; Richard Dyer; Meredith Buxton; Yun Gong; Yun Wu; Nuhad Ibrahim; Eleni Andreopoulou; Naoto T Ueno; Kelly Hunt; Wei Yang; Arlene Nazario; Angela DeMichele; Joyce O'Shaughnessy; Gabriel N Hortobagyi; W Fraser Symmans
A genomic predictor of response and survival following taxane-anthracycline chemotherapy for invasive breast cancer.
JAMA : the journal of the American Medical Association 2011;305(18):1873-81.
2011: Charles Coutant; Roman Rouzier; Yuan Qi; Jacqueline Lehmann-Che; Giampaolo Bianchini; Takayuki Iwamoto; Gabriel N Hortobagyi; W Fraser Symmans; Serge Uzan; Fabrice Andre; Hugues de Thé; Lajos Pusztai
Distinct p53 gene signatures are needed to predict prognosis and response to chemotherapy in ER-positive and ER-negative breast cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(8):2591-601.
2011: Min Yi; Thomas A Buchholz; Funda Meric-Bernstam; Isabelle Bedrosian; Rosa F Hwang; Merrick I Ross; Henry M Kuerer; Sheng Luo; Ana M Gonzalez-Angulo; Aman U Buzdar; W Fraser Symmans; Barry W Feig; Anthony Lucci; Eugene H Huang; Kelly K Hunt
Classification of ipsilateral breast tumor recurrences after breast conservation therapy can predict patient prognosis and facilitate treatment planning.
Annals of surgery 2011;253(3):572-9.
2011: Min Yi; Steven J Kronowitz; Funda Meric-Bernstam; Barry W Feig; W Fraser Symmans; Anthony Lucci; Merrick I Ross; Gildy V Babiera; Henry M Kuerer; Kelly K Hunt
Local, regional, and systemic recurrence rates in patients undergoing skin-sparing mastectomy compared with conventional mastectomy.
Cancer 2011;117(5):916-24.
2011: Takayuki Iwamoto; Giampaolo Bianchini; Daniel J Booser; Yuan Qi; Charles Coutant; Christine Ya-Hui Shiang; Libero Santarpia; Junji Matsuoka; Gabriel N Hortobagyi; W Fraser Symmans; Frankie A Holmes; Joyce A O'Shaughnessy; Beth Hellerstedt; John Pippen; Fabrice Andre; Richard Simon; Lajos Pusztai
Gene pathways associated with prognosis and chemotherapy sensitivity in molecular subtypes of breast cancer.
Journal of the National Cancer Institute 2011;103(3):264-72.
2011: Takayuki Iwamoto; Giampaolo Bianchini; Yuan Qi; Massimo Cristofanilli; Anthony Lucci; Wendy A Woodward; James M Reuben; Junji Matsuoka; Yun Gong; Savitri Krishnamurthy; Vicente Valero; Gabriel N Hortobagyi; Fredika Robertson; W Fraser Symmans; Lajos Pusztai; Naoto T Ueno
Different gene expressions are associated with the different molecular subtypes of inflammatory breast cancer.
Breast cancer research and treatment 2011;125(3):785-95.
2011: Ana M Gonzalez-Angulo; Bryan T Hennessy; Gabriel N Hortobagyi; Zhenlin Ju; Wenbin Liu; Ana Lluch; Funda Meric-Bernstam; Jan Alsner; Sam Aparicio; Anne-Lise Borresen-Dale; Russell Broaddus; Powel Brown; Mark S Carey; Kevin R Coombes; Lei Deng; Simen Myhre; Jens Overgaard; Lajos Pusztai; Aysegul Sahin; Corey Speers; W Fraser Symmans; Gordon B Mills
Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer.
Clinical proteomics 2011;8(1):11.
2011: Qiyuan Li; Lajos Pusztai; Andrea L Richardson; C Sotiriou; W Fraser Symmans; Nicolai J Birkbak; Søren Brunak; Christine Desmedt; Aron C Eklund; Benjamin Haibe-Kains; Zoltan Szallasi
Consistent metagenes from cancer expression profiles yield agent specific predictors of chemotherapy response.
BMC bioinformatics 2011;12():310.
2011: Henry M Kuerer; Aman U Buzdar; Elizabeth A Mittendorf; Francisco J Esteva; Anthony Lucci; Luis M Vence; Laszlo Radvanyi; Funda Meric-Bernstam; Kelly K Hunt; W Fraser Symmans
Biologic and immunologic effects of preoperative trastuzumab for ductal carcinoma in situ of the breast.
Cancer 2011;117(1):39-47.
2010: Giampaolo Bianchini; Takayuki Iwamoto; Yuan Qi; Charles Coutant; Christine Y Shiang; Bailang Wang; Libero Santarpia; Vicente Valero; Gabriel N Hortobagyi; W Fraser Symmans; Luca Gianni; Lajos Pusztai
Prognostic and therapeutic implications of distinct kinase expression patterns in different subtypes of breast cancer.
Cancer research 2010;70(21):8852-62.
2010: Adel Tabchy; Vicente Valero; Tatiana Vidaurre; Ana Lluch; Henry Gomez; Miguel Martin; Yuan Qi; Luis Javier Barajas-Figueroa; Eduardo Souchon; Charles Coutant; Franco D Doimi; Nuhad K Ibrahim; Yun Gong; Gabriel N Hortobagyi; Kenneth R Hess; W Fraser Symmans; Lajos Pusztai
Evaluation of a 30-gene paclitaxel, fluorouracil, doxorubicin, and cyclophosphamide chemotherapy response predictor in a multicenter randomized trial in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(21):5351-61.
2010: Shivani S Shinde; Michele R Forman; Henry M Kuerer; Kai Yan; Florentia Peintinger; Kelly K Hunt; Gabriel N Hortobagyi; Lajos Pusztai; W Fraser Symmans
Higher parity and shorter breastfeeding duration: association with triple-negative phenotype of breast cancer.
Cancer 2010;116(21):4933-43.
2010: Giampaolo Bianchini; Yuan Qi; Ricardo H Alvarez; Takayuki Iwamoto; Charles Coutant; Nuhad K Ibrahim; Vicente Valero; Massimo Cristofanilli; Marjorie C Green; Laszlo Radvanyi; Christos Hatzis; Gabriel N Hortobagyi; Fabrice Andre; Luca Gianni; W Fraser Symmans; Lajos Pusztai
Molecular anatomy of breast cancer stroma and its prognostic value in estrogen receptor-positive and -negative cancers.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(28):4316-23.
2010: W Fraser Symmans; Christos Hatzis; Christos Sotiriou; Fabrice Andre; Florentia Peintinger; Peter Regitnig; Guenter Daxenbichler; Christine Desmedt; Julien Domont; Christian Marth; Suzette Delaloge; Thomas Bauernhofer; Vicente Valero; Daniel J Booser; Gabriel N Hortobagyi; Lajos Pusztai
Genomic index of sensitivity to endocrine therapy for breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(27):4111-9.
2010: Sherene Loi; Benjamin Haibe-Kains; Samira Majjaj; Francoise Lallemand; Virginie Durbecq; Denis Larsimont; Ana M Gonzalez-Angulo; Lajos Pusztai; W Fraser Symmans; Alberto Bardelli; Paul Ellis; Andrew N J Tutt; Cheryl E Gillett; Bryan T Hennessy; Gordon B Mills; Wayne A Phillips; Martine J Piccart; Terence P Speed; Grant A McArthur; C Sotiriou
PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(22):10208-13.
2010: Stacy Moulder; Kai Yan; Fei Huang; Kenneth R Hess; Cornelia Liedtke; Feng Lin; Christos Hatzis; Gabriel N Hortobagyi; W Fraser Symmans; Lajos Pusztai
Development of candidate genomic markers to select breast cancer patients for dasatinib therapy.
Molecular cancer therapeutics 2010;9(5):1120-7.
2010: Abigail S Caudle; Ana M Gonzalez-Angulo; Kelly K Hunt; Ping Liu; Lajos Pusztai; W Fraser Symmans; Henry M Kuerer; Elizabeth A Mittendorf; Gabriel N Hortobagyi; Funda Meric-Bernstam
Predictors of tumor progression during neoadjuvant chemotherapy in breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010;28(11):1821-8.
2010: Nicolai Juul; Zoltan Szallasi; Aron C Eklund; Qiyuan Li; Rebecca A Burrell; Marco Gerlinger; Vicente Valero; Eleni Andreopoulou; Francisco J Esteva; W Fraser Symmans; Christine Desmedt; Benjamin Haibe-Kains; C Sotiriou; Lajos Pusztai; Charles Swanton
Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials.
The lancet oncology 2010;11(4):358-65.
2010: Jae K Lee; Charles Coutant; Young-Chul Kim; Yuan Qi; Dan Theodorescu; W Fraser Symmans; Keith Baggerly; Roman Rouzier; Lajos Pusztai
Prospective comparison of clinical and genomic multivariate predictors of response to neoadjuvant chemotherapy in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(2):711-8.
2010: Jacqueline Lehmann-Che; Fabrice André; Christine Desmedt; Chafika Mazouni; Sylvie Giacchetti; Elisabeth Turpin; Marc Espié; Louis-François Plassa; Michel Marty; Philippe Bertheau; Christos Sotiriou; Martine Piccart; W Fraser Symmans; Lajos Pusztai; Hugues de Thé
Cyclophosphamide dose intensification may circumvent anthracycline resistance of p53 mutant breast cancers.
The oncologist 2010;15(3):246-52.
2010: Vlad Popovici; Weijie Chen; Brandon G Gallas; Christos Hatzis; Weiwei Shi; Frank W Samuelson; Yuri Nikolsky; Marina Tsyganova; Alex Ishkin; Tatiana Nikolskaya; Kenneth R Hess; Vicente Valero; Daniel Booser; Mauro Delorenzi; Gabriel N Hortobagyi; Leming Shi; W Fraser Symmans; Lajos Pusztai
Effect of training-sample size and classification difficulty on the accuracy of genomic predictors.
Breast cancer research : BCR 2010;12(1):R5.
2009: C Liedtke; Kristine Broglio; S Moulder; L Hsu; Shu-Wan Kau; W Fraser Symmans; Constance T Albarracin; Funda Meric-Bernstam; Wendy A Woodward; Richard L Theriault; L Kiesel; Gabriel N Hortobagyi; Lajos Pusztai; Ana M Gonzalez-Angulo
Prognostic impact of discordance between triple-receptor measurements in primary and recurrent breast cancer.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2009;20(12):1953-8.
2009: Xiaohong Leng; Tian Ding; Hui Lin; Yan Wang; Limei Hu; Jianhua Hu; Barry Feig; Wei Zhang; Lajos Pusztai; W Fraser Symmans; Yun Wu; Ralph B Arlinghaus
Inhibition of lipocalin 2 impairs breast tumorigenesis and metastasis.
Cancer research 2009;69(22):8579-84.
2009: Lajos Pusztai; Jong-Hyeon Jeong; Yun Gong; Jeffrey S Ross; Chungyeul Kim; Soonmyung Paik; Roman Rouzier; Fabrice Andre; Gabriel N Hortobagyi; Norman Wolmark; W Fraser Symmans
Evaluation of microtubule-associated protein-Tau expression as a prognostic and predictive marker in the NSABP-B 28 randomized clinical trial.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(26):4287-92.
2009: Yun Gong; William Sweet; Yi-Jing Duh; Larry Greenfield; Emily Tarco; Smita Trivedi; W Fraser Symmans; Jorma Isola; Nour Sneige
Performance of chromogenic in situ hybridization on testing HER2 Status in breast carcinomas with chromosome 17 polysomy and equivocal (2+) herceptest results: a study of two institutions using the conventional and new ASCO/CAP scoring criteria.
American journal of clinical pathology 2009;132(2):228-36.
2009: Cornelia Liedtke; Christos Hatzis; W Fraser Symmans; Christine Desmedt; Benjamin Haibe-Kains; Vicente Valero; Henry M Kuerer; Gabriel N Hortobagyi; Martine Piccart-Gebhart; Christos Sotiriou; Lajos Pusztai
Genomic grade index is associated with response to chemotherapy in patients with breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(19):3185-91.
2009: Jeffrey S Ross; Elzbieta A Slodkowska; W Fraser Symmans; Lajos Pusztai; Peter M Ravdin; Gabriel N Hortobagyi
The HER-2 receptor and breast cancer: ten years of targeted anti-HER-2 therapy and personalized medicine.
The oncologist 2009;14(4):320-68.
2009: Yun Gong; William Sweet; Yi-Jing Duh; Larry Greenfield; Yuan Fang; Jianxin Zhao; Emily Tarco; W Fraser Symmans; Jorma Isola; Nour Sneige
Chromogenic in situ hybridization is a reliable method for detecting HER2 gene status in breast cancer: a multicenter study using conventional scoring criteria and the new ASCO/CAP recommendations.
American journal of clinical pathology 2009;131(4):490-7.
2009: Fabrice Andre; Bastien Job; Philippe Dessen; Attila Tordai; Stefan Michiels; Cornelia Liedtke; Catherine Richon; Kai Yan; Bailang Wang; Gilles Vassal; Suzette Delaloge; Gabriel N Hortobagyi; W Fraser Symmans; Vladimir Lazar; Lajos Pusztai
Molecular characterization of breast cancer with high-resolution oligonucleotide comparative genomic hybridization array.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(2):441-51.
2009: Henry M Kuerer; Constance T Albarracin; Wei Tse Yang; Robert Cardiff; Abenaa M Brewster; W Fraser Symmans; Nola M Hylton; Lavinia P Middleton; Savitri Krishnamurthy; George H Perkins; Gildy Babiera; Mary E Edgerton; Brian J Czerniecki; Banu K Arun; Gabriel N Hortobagyi
Ductal carcinoma in situ: state of the science and roadmap to advance the field.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009;27(2):279-88.
2009: Jing Wang; Sijin Wen; W Fraser Symmans; Lajos Pusztai; Kevin R Coombes
The bimodality index: a criterion for discovering and ranking bimodal signatures from cancer gene expression profiling data.
Cancer informatics 2009;7():199-216.
2008: Stacy L Moulder; W Fraser Symmans; Daniel J Booser; Timothy L Madden; Cindy Lipsanen; Linda Yuan; Abenaa Brewster; Massimo Cristofanilli; Kelly K Hunt; Thomas Buchholz; James Zwiebel; Vicente Valero; Gabriel N Hortobagyi; Francisco J Esteva
Phase I/II study of G3139 (Bcl-2 antisense oligonucleotide) in combination with doxorubicin and docetaxel in breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(23):7909-16.
2008: Florentia Peintinger; Aman U Buzdar; Henry M Kuerer; Jaime A Mejia, M.D.; Christos Hatzis; Ana M Gonzalez-Angulo; Lajos Pusztai; Francisco J Esteva; S S Dawood; Marjorie C Green; Gabriel N Hortobagyi; W Fraser Symmans
Hormone receptor status and pathologic response of HER2-positive breast cancer treated with neoadjuvant chemotherapy and trastuzumab.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(12):2020-5.
2008: Lajos Pusztai; Kristine Broglio; Fabrice Andre; W Fraser Symmans; Kenneth R Hess; Gabriel N Hortobagyi
Effect of molecular disease subsets on disease-free survival in randomized adjuvant chemotherapy trials for estrogen receptor-positive breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(28):4679-83.
2008: Katherine Stemke-Hale; Ana Maria Gonzalez-Angulo; Ana Lluch; Richard M Neve; Wen-Lin Kuo; Michael Davies; Mark Carey; Zhi Hu; Yinghui Guan; Aysegul Sahin; W Fraser Symmans; Lajos Pusztai; Laura K Nolden; Hugo Horlings; Katrien Berns; Mien-Chie Hung; Marc J van de Vijver; Vicente Valero; Joe Gray; René Bernards; Gordon B Mills; Bryan T. J. Hennessy
An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer.
Cancer research 2008;68(15):6084-91.
2008: M Zoubir; Marie-Christine Mathieu; Chafika Mazouni; C Liedtke; L Corley; S Geha; J Bouaziz; Marc Spielmann; F Drusche; W Fraser Symmans; Suzette Delaloge; Fabrice Andre
Modulation of ER phosphorylation on serine 118 by endocrine therapy: a new surrogate marker for efficacy.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2008;19(8):1402-6.
2008: Jeffrey S Ross; Christos Hatzis; W Fraser Symmans; Lajos Pusztai; Gabriel N Hortobágyi
Commercialized multigene predictors of clinical outcome for breast cancer.
The oncologist 2008;13(5):477-93.
2008: W Fraser Symmans; Gabriel N Hortobagyi
Fingerprinting lymph node metastases.
Annals of surgical oncology 2008;15(5):1275-6.
2008: Florentia Peintinger; Henry M Kuerer; S E McGuire; Roland L Bassett; Lajos Pusztai; W Fraser Symmans
Residual specimen cellularity after neoadjuvant chemotherapy for breast cancer.
The British journal of surgery 2008;95(4):433-7.
2008: Cornelia Liedtke; Chafika Mazouni; Kenneth R Hess; Fabrice André; Attila Tordai; Jaime A Mejia, M.D.; W Fraser Symmans; Ana M Gonzalez-Angulo; Bryan T. J. Hennessy; Marjorie Green; Massimo Cristofanilli; Gabriel N Hortobagyi; Lajos Pusztai
Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2008;26(8):1275-81.
2008: Fabrice Andre; Chafika Mazouni; Cornelia Liedtke; Shu-Wan Kau; Debby Frye; Marjorie Green; Ana M Gonzalez-Angulo; W Fraser Symmans; Gabriel N Hortobagyi; Lajos Pusztai
HER2 expression and efficacy of preoperative paclitaxel/FAC chemotherapy in breast cancer.
Breast cancer research and treatment 2008;108(2):183-90.
2008: Attila Tordai; Jing Wang; Fabrice Andre; Cornelia Liedtke; Kai Yan; C Sotiriou; Gabriel N Hortobagyi; W Fraser Symmans; Lajos Pusztai
Evaluation of biological pathways involved in chemotherapy response in breast cancer.
Breast cancer research : BCR 2008;10(2):R37.
2008: Cornelia Liedtke; Luca Cardone; Attila Tordai; Kai Yan; Henry L Gomez; Luis J Barajas Figureoa; Rebekah E Hubbard; Vicente Valero; Eduardo A Souchon; W Fraser Symmans; Gabriel N Hortobagyi; Alberto Bardelli; Lajos Pusztai
PIK3CA-activating mutations and chemotherapy sensitivity in stage II-III breast cancer.
Breast cancer research : BCR 2008;10(2):R27.
2008: Shaheenah Dawood; Kristine Broglio; Shu-Wan Kau; Rabiul Islam; W Fraser Symmans; Thomas Buchholz; Sean E McGuire; Funda Meric-Bernstam; Massimo Cristofanilli; Gabriel N Hortobágyi; Ana M Gonzalez-Angulo
Prognostic value of initial clinical disease stage after achieving pathological complete response.
The oncologist 2008;13(1):6-15.
2007: Leslie K Diaz; Vincent L Cryns; W Fraser Symmans; Nour Sneige
Triple negative breast carcinoma and the basal phenotype: from expression profiling to clinical practice.
Advances in anatomic pathology 2007;14(6):419-30.
2007: Yun Gong; W Fraser Symmans; Lajos Pusztai
Gene-expression microarrays provide new prognostic and predictive tests for breast cancer.
Pharmacogenomics 2007;8(10):1359-68.
2007: Thao Vo; Yan Xing; Funda Meric-Bernstam; Nadeem Mirza; Georges Vlastos; W Fraser Symmans; George H Perkins; Thomas Buchholz; Gildy V Babiera; Henry M Kuerer; Isabelle Bedrosian; Jeri S Akins; Kelly K Hunt
Long-term outcomes in patients with mucinous, medullary, tubular, and invasive ductal carcinomas after lumpectomy.
American journal of surgery 2007;194(4):527-31.
2007: W Fraser Symmans; Florentia Peintinger; Christos Hatzis; Radhika Rajan; Henry M Kuerer; Vicente Valero; Lina Assad; Anna Poniecka; Bryan T. J. Hennessy; Marjorie Green; Aman U Buzdar; S Eva Singletary; Gabriel N Hortobagyi; Lajos Pusztai
Measurement of residual breast cancer burden to predict survival after neoadjuvant chemotherapy.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(28):4414-22.
2007: Shaheenah Dawood; Ana M Gonzalez-Angulo; Florentia Peintinger; Kristine Broglio; W Fraser Symmans; Shu-Wan Kau; Rabiul Islam; Gabriel N Hortobagyi; Aman U Buzdar
Efficacy and safety of neoadjuvant trastuzumab combined with paclitaxel and epirubicin: a retrospective review of the M. D. Anderson experience.
Cancer 2007;110(6):1195-200.
2007: Stephanie A Williams; Richard A Ehlers; Kelly K Hunt; Min Yi; Henry M Kuerer; S Eva Singletary; Merrick I Ross; Barry W Feig; W Fraser Symmans; Funda Meric-Bernstam
Metastases to the breast from nonbreast solid neoplasms: presentation and determinants of survival.
Cancer 2007;110(4):731-7.
2007: Florentia Peintinger; Keith Anderson; Chafika Mazouni; Henry M Kuerer; Christos Hatzis; Feng Lin; Gabriel N Hortobagyi; W Fraser Symmans; Lajos Pusztai
Thirty-gene pharmacogenomic test correlates with residual cancer burden after preoperative chemotherapy for breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(14):4078-82.
2007: Chafika Mazouni; Florentia Peintinger; Shu Wan-Kau; Fabrice Andre; Ana M Gonzalez-Angulo; W Fraser Symmans; Funda Meric-Bernstam; Vicente Valero; Gabriel N Hortobagyi; Lajos Pusztai
Residual ductal carcinoma in situ in patients with complete eradication of invasive breast cancer after neoadjuvant chemotherapy does not adversely affect patient outcome.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2007;25(19):2650-5.
2007: Jeffrey S Ross; W Fraser Symmans; Lajos Pusztai; Gabriel N Hortobagyi
Standardizing slide-based assays in breast cancer: hormone receptors, HER2, and sentinel lymph nodes.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(10):2831-5.
2007: Chafika Mazouni; Shu-Wan Kau; Debra Frye; Fabrice Andre; Henry M Kuerer; Thomas Buchholz; W Fraser Symmans; Keith Anderson; Kenneth R Hess; Ana M Gonzalez-Angulo; Gabriel N Hortobagyi; Aman U Buzdar; Lajos Pusztai
Inclusion of taxanes, particularly weekly paclitaxel, in preoperative chemotherapy improves pathologic complete response rate in estrogen receptor-positive breast cancers.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2007;18(5):874-80.
2007: W Fraser Symmans
A pathologist's perspective on emerging genomic tests for breast cancer.
Seminars in oncology 2007;34(2 Suppl 3):S4-9.
2007: Fabrice Andre; Christos Hatzis; Keith Anderson; Christos Sotiriou; Chafika Mazouni; Jaime A Mejia, M.D.; Bailiang Wang; Gabriel N Hortobagyi; W Fraser Symmans; Lajos Pusztai
Microtubule-associated protein-tau is a bifunctional predictor of endocrine sensitivity and chemotherapy resistance in estrogen receptor-positive breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(7):2061-7.
2007: Yun Gong; Kai Yan; Feng Lin; Keith Anderson; Christos Sotiriou; Fabrice Andre; Frankie A Holmes; Vicente Valero; Daniel J Booser; John Pippen; Svetislava Vukelja; Henry Gomez; Jaime A Mejia, M.D.; Luis J Barajas; Kenneth R Hess; Nour Sneige; Gabriel N Hortobagyi; Lajos Pusztai; W Fraser Symmans
Determination of oestrogen-receptor status and ERBB2 status of breast carcinoma: a gene-expression profiling study.
The lancet oncology 2007;8(3):203-11.
2007: Francisco J Esteva; Jing Wang; Feng Lin; Jaime A Mejia, M.D.; Kai Yan; Kadri Altundag; Vicente Valero; Aman U Buzdar; Gabriel N Hortobagyi; W Fraser Symmans; Lajos Pusztai
CD40 signaling predicts response to preoperative trastuzumab and concomitant paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide in HER-2-overexpressing breast cancer.
Breast cancer research : BCR 2007;9(6):R87.
2007: Aman U Buzdar; Vicente Valero; Nuhad K Ibrahim; Deborah Francis; Kristine Broglio; Richard L Theriault; Lajos Pusztai; Marjorie C Green; S Eva Singletary; Kelly K Hunt; Aysegul A Sahin; Francisco J Esteva; W Fraser Symmans; Michael S Ewer; Thomas Buchholz; Gabriel N Hortobagyi
Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: an update of the initial randomized study population and data of additional patients treated with the same regimen.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(1):228-33.
2006: Florentia Peintinger; Henry M Kuerer; Keith Anderson; Judy C Boughey; Funda Meric-Bernstam; S Eva Singletary; Kelly K Hunt; Gary J Whitman; Tanya W Stephens; Aman U Buzdar; Marjorie C Green; W Fraser Symmans
Accuracy of the combination of mammography and sonography in predicting tumor response in breast cancer patients after neoadjuvant chemotherapy.
Annals of surgical oncology 2006;13(11):1443-9.
2006: Florentia Peintinger; W Fraser Symmans; Ana M Gonzalez-Angulo; Judy C Boughey; Aman U Buzdar; Tse-Kuan Yu; Kelly K Hunt; S Eva Singletary; Gildy V Babiera; Anthony Lucci; Funda Meric-Bernstam; Henry M Kuerer
The safety of breast-conserving surgery in patients who achieve a complete pathologic response after neoadjuvant chemotherapy.
Cancer 2006;107(6):1248-54.
2006: Kenneth R Hess; Keith Anderson; W Fraser Symmans; Vicente Valero; Nuhad Ibrahim; Jaime A Mejia, M.D.; Daniel J Booser; Richard L Theriault; Aman U Buzdar; Peter J Dempsey; Roman Rouzier; Nour Sneige; Jeffrey S Ross; Tatiana Vidaurre; Henry L Gómez; Gabriel N Hortobagyi; Lajos Pusztai
Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2006;24(26):4236-44.
2006: Lajos Pusztai; Chafika Mazouni; Keith Anderson; Yun Wu; W Fraser Symmans
Molecular classification of breast cancer: limitations and potential.
The oncologist 2006;11(8):868-77.
2006: Kazumi Kawase; Isis Gayed; Kelly K Hunt; Henry M Kuerer; Jeri S Akins; Min Yi; Lynn Grimes; Gildy V Babiera; Merrick I Ross; Barry W Feig; Frederick C Ames; S Eva Singletary; Thomas Buchholz; W Fraser Symmans; Funda Meric-Bernstam
Use of lymphoscintigraphy defines lymphatic drainage patterns before sentinel lymph node biopsy for breast cancer.
Journal of the American College of Surgeons 2006;203(1):64-72.
2006: Rita Nahta; Linda X H Yuan; Derek J Fiterman; LI Zhang; W Fraser Symmans; Naoto T Ueno; Francisco J Esteva
B cell translocation gene 1 contributes to antisense Bcl-2-mediated apoptosis in breast cancer cells.
Molecular cancer therapeutics 2006;5(6):1593-601.
2006: W Fraser Symmans
Genomic testing for sensitivity of breast cancer to hormonal therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(7 Pt 1):1954-5.
2006: Keith Anderson; Kenneth R Hess; Mini Kapoor; Stephen Tirrell; Jean Courtemanche; Bailiang Wang; Yun Wu; Yun Gong; Gabriel N Hortobagyi; W Fraser Symmans; Lajos Pusztai
Reproducibility of gene expression signature-based predictions in replicate experiments.
Clinical cancer research : an official journal of the American Association for Cancer Research 2006;12(6):1721-7.
2006: Yuan Ji; Kevin R Coombes; Jiexin Zhang; Sijin Wen; James Mitchell; Lajos Pusztai; W Fraser Symmans; Jing Wang
RefSeq refinements of UniGene-based gene matching improve the correlation of expression measurements between two microarray platforms.
Applied bioinformatics 2006;5(2):89-98.
2006: Linda J Adepoju; W Fraser Symmans; Gildy V Babiera; S Eva Singletary; Banu Arun; Nour Sneige; Lajos Pusztai; Thomas Buchholz; Aysegul Sahin; Kelly K Hunt; Funda Meric-Bernstam; Merrick I Ross; Frederick C Ames; Henry M Kuerer
Impact of concurrent proliferative high-risk lesions on the risk of ipsilateral breast carcinoma recurrence and contralateral breast carcinoma development in patients with ductal carcinoma in situ treated with breast-conserving therapy.
Cancer 2006;106(1):42-50.
2005: Jeffrey S Ross; W Fraser Symmans; Lajos Pusztai; Gabriel N Hortobagyi
Pharmacogenomics and clinical biomarkers in drug discovery and development.
American journal of clinical pathology 2005;124 Suppl():S29-41.
2005: W Fraser Symmans; Derek J Fiterman; S K Anderson; Mark Ayers; Roman Rouzier; Valerie Dunmire; James Stec; Vicente Valero; Nour Sneige; Constance T Albarracin; Yun Wu; Jeffrey S Ross; Peter Wagner; Richard L Theriault; Banu Arun; Henry M Kuerer; Kenneth R Hess; Wei Zhang; Gabriel N Hortobagyi; Lajos Pusztai
A single-gene biomarker identifies breast cancers associated with immature cell type and short duration of prior breastfeeding.
Endocrine-related cancer 2005;12(4):1059-69.
2005: Roman Rouzier; Lajos Pusztai; Suzette Delaloge; Ana M Gonzalez-Angulo; Fabrice Andre; Kenneth R Hess; Aman U Buzdar; Jean-Rémi Garbay; Marc Spielmann; Marie-Christine Mathieu; W Fraser Symmans; Peter Wagner; david atallah; Vicente Valero; Donald A Berry; Gabriel N Hortobagyi
Nomograms to predict pathologic complete response and metastasis-free survival after preoperative chemotherapy for breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(33):8331-9.
2005: Ana M Tari; Ann-Marie Simeone; Yu-Jiang Li; Yolanda Gutierrez-Puente; Syeling Lai; W Fraser Symmans
Cyclooxygenase-2 protein reduces tamoxifen and N-(4-hydroxyphenyl)retinamide inhibitory effects in breast cancer cells.
Laboratory investigation; a journal of technical methods and pathology 2005;85(11):1357-67.
2005: Luca Gianni; Milvia Zambetti; Kim Clark; Joffre Baker; Maureen Cronin; Jenny Wu; Gabriella Mariani; Jaime Rodriguez; Marialuisa Carcangiu; Drew Watson; Pinuccia Valagussa; Roman Rouzier; W Fraser Symmans; Jeffrey S Ross; Gabriel N Hortobagyi; Lajos Pusztai; Steven Shak
Gene expression profiles in paraffin-embedded core biopsy tissue predict response to chemotherapy in women with locally advanced breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(29):7265-77.
2005: Marjorie C Green; Aman U Buzdar; Terry Smith; Nuhad K Ibrahim; Vicente Valero; Marguerite F Rosales; Massimo Cristofanilli; Daniel J Booser; Lajos Pusztai; Edgardo Rivera; Richard L Theriault; Cynthia Carter; Debra Frye; Kelly K Hunt; W Fraser Symmans; Eric A Strom; Aysegul A Sahin; William Sikov; Gabriel N Hortobagyi
Weekly paclitaxel improves pathologic complete remission in operable breast cancer when compared with paclitaxel once every 3 weeks.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2005;23(25):5983-92.
2005: Roman Rouzier; Charles M Perou; W Fraser Symmans; Nuhad Ibrahim; Massimo Cristofanilli; Keith Anderson; Kenneth R Hess; James Stec; Mark Ayers; Peter Wagner; Paolo Morandi; Chang Fan; Islam Rabiul; Jeffrey S Ross; Gabriel N Hortobagyi; Lajos Pusztai
Breast cancer molecular subtypes respond differently to preoperative chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer Research 2005;11(16):5678-85.
2005: Roman Rouzier; Radhika Rajan; Peter Wagner; Kenneth R Hess; David L Gold; James Stec; Mark Ayers; Jeffrey S Ross; Peter Zhang; Thomas Buchholz; Henry M Kuerer; Marjorie Green; Banu Arun; Gabriel N Hortobagyi; W Fraser Symmans; Lajos Pusztai
Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancer.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(23):8315-20.
2005: Tina W F Yen; Kelly K Hunt; Merrick I Ross; Nadeem Q Mirza; Gildy V Babiera; Funda Meric-Bernstam; S Eva Singletary; W Fraser Symmans; Sharon H Giordano; Barry W Feig; Frederick C Ames; Henry M Kuerer
Predictors of invasive breast cancer in patients with an initial diagnosis of ductal carcinoma in situ: a guide to selective use of sentinel lymph node biopsy in management of ductal carcinoma in situ.
Journal of the American College of Surgeons 2005;200(4):516-26.
2005: Jeffrey S Ross; W Fraser Symmans; Lajos Pusztai; Gabriel N Hortobagyi
Breast cancer biomarkers.
Advances in clinical chemistry 2005;40():99-125.
2004: Lajos Pusztai; Roman Rouzier; Peter Wagner; W Fraser Symmans
Individualized chemotherapy treatment for breast cancer: is it necessary? Is it feasible?
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2004;7(6):325-31.
2004: Jeffrey S Ross; David P Schenkein; Robert Pietrusko; Mark Rolfe; Gerald P Linette; James Stec; Nancy Stagliano; Geoffrey S Ginsburg; W Fraser Symmans; Lajos Pusztai; Gabriel N Hortobagyi
Targeted therapies for cancer 2004.
American journal of clinical pathology 2004;122(4):598-609.
2004: Radhika Rajan; Francisco J Esteva; W Fraser Symmans
Pathologic changes in breast cancer following neoadjuvant chemotherapy: implications for the assessment of response.
Clinical breast cancer 2004;5(3):235-8.
2004: Jeffrey S Ross; David P Schenkein; Oscar Kashala; Gerald P Linette; James Stec; W Fraser Symmans; Lajos Pusztai; Gabriel N Hortobagyi
Pharmacogenomics.
Advances in anatomic pathology 2004;11(4):211-20.
2004: Mark Ayers; W Fraser Symmans; James Stec; Andrew I Damokosh; E Clark; K Hess; M Lecocke; J Metivier; Daniel J Booser; Nuhad Ibrahim; Vicente Valero; Melanie Royce; Banu Arun; G Whitman; J Ross; Nour Sneige; Gabriel N Hortobagyi; Lajos Pusztai
Gene expression profiles predict complete pathologic response to neoadjuvant paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide chemotherapy in breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004;22(12):2284-93.
2004: Lajos Pusztai; Betsy Gregory; Keith A Baggerly; Bo Peng; John M Koomen; Henry M Kuerer; Francisco J Esteva; W Fraser Symmans; Peter Wagner; Gabriel N Hortobagyi; Christine Laronga; O John Semmes; George L Wright; Richard R Drake; Antonia Vlahou
Pharmacoproteomic analysis of prechemotherapy and postchemotherapy plasma samples from patients receiving neoadjuvant or adjuvant chemotherapy for breast carcinoma.
Cancer 2004;100(9):1814-22.
2004: Radhika Rajan; Anna Poniecka; Terry L Smith; Ying Yang; Deborah Frye; Lajos Pusztai; Derek J Fiterman; Eva Gal-Gombos; Gary J Whitman; Roman Rouzier; Marjorie Green; Henry M Kuerer; Aman U Buzdar; Gabriel N Hortobagyi; W Fraser Symmans
Change in tumor cellularity of breast carcinoma after neoadjuvant chemotherapy as a variable in the pathologic assessment of response.
Cancer 2004;100(7):1365-73.
2004: Jeffrey S Ross; Jonathan A Fletcher; Kenneth J Bloom; Gerald P Linette; James Stec; W Fraser Symmans; Lajos Pusztai; Gabriel N Hortobagyi
Targeted therapy in breast cancer: the HER-2/neu gene and protein.
Molecular & cellular proteomics : MCP 2004;3(4):379-98.
2004: Xishan Hao; Baocun Sun; Limei Hu; Harri Lähdesmäki; Valerie Dunmire; Yumei Feng; Shi-Wu Zhang; Huamin Wang; Chunlei Wu; Hua Wang; Gregory N Fuller; W Fraser Symmans; Ilya Shmulevich; Wei Zhang
Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis.
Cancer 2004;100(6):1110-22.
2004: Jeffrey S Ross; Gerald P Linette; James Stec; Edward Clark; Mark Ayers; Nick Leschly; W Fraser Symmans; Gabriel N Hortobagyi; Lajos Pusztai
Breast cancer biomarkers and molecular medicine: part II.
Expert review of molecular diagnostics 2004;4(2):169-88.
2004: Yun Gong; W Fraser Symmans; Savitri Krishnamurthy; Shobha Patel; Nour Sneige
Optimal fixation conditions for immunocytochemical analysis of estrogen receptor in cytologic specimens of breast carcinoma.
Cancer 2004;102(1):34-40.
2003: Jeffrey S Ross; Jonathan A Fletcher; Kenneth J Bloom; Gerald P Linette; James Stec; Edward Clark; Mark Ayers; W Fraser Symmans; Lajos Pusztai; Gabriel N Hortobagyi
HER-2/neu testing in breast cancer.
American journal of clinical pathology 2003;120 Suppl():S53-71.
2003: Lajos Pusztai; Jim Hou Zhen; Banu Arun; Edgardo Rivera; Clark Whitehead; W Joseph Thompson; Kimberly M Nealy; Amy Gibbs; W Fraser Symmans; Francisco J Esteva; Daniel J Booser; James L Murray; Vicente Valero; Terry L Smith; Gabriel N Hortobagyi
Phase I and II study of exisulind in combination with capecitabine in patients with metastatic breast cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2003;21(18):3454-61.
2003: Jeffrey S Ross; Gerald P Linette; James Stec; Edward Clark; Mark Ayers; Nick Leschly; W Fraser Symmans; Gabriel N Hortobagyi; Lajos Pusztai
Breast cancer biomarkers and molecular medicine.
Expert review of molecular diagnostics 2003;3(5):573-85.
2003: Lei Wang; Lindsay Duke; Peter S Zhang; Ralph B Arlinghaus; W Fraser Symmans; Aysegul Sahin; Richard Mendez; Jia Le Dai
Alternative splicing disrupts a nuclear localization signal in spleen tyrosine kinase that is required for invasion suppression in breast cancer.
Cancer research 2003;63(15):4724-30.
2003: Lajos Pusztai; Mark Ayers; James Stec; Edward Clark; Kenneth Hess; David N Stivers; Andrew I Damokosh; Nour Sneige; Thomas Buchholz; Francisco J Esteva; Banu Arun; Massimo Cristofanilli; Daniel J Booser; Marguerite Rosales; Vicente Valero; Constantine Adams; Gabriel N Hortobagyi; W Fraser Symmans
Gene expression profiles obtained from fine-needle aspirations of breast cancer reliably identify routine prognostic markers and reveal large-scale molecular differences between estrogen-negative and estrogen-positive tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(7):2406-15.
2003: W Fraser Symmans; Mark Ayers; Edwin A Clark; James Stec; Kenneth R Hess; Nour Sneige; Thomas Buchholz; Savitri Krishnamurthy; Nuhad K Ibrahim; Aman U Buzdar; Richard L Theriault; Marguerite F Rosales; Eva S Thomas; Karin Gwyn; Marjorie C Green; Abdul R Syed; Gabriel N Hortobagyi; Lajos Pusztai
Total RNA yield and microarray gene expression profiles from fine-needle aspiration biopsy and core-needle biopsy samples of breast carcinoma.
Cancer 2003;97(12):2960-71.
2003: Fan Zhang; Ying Yang; Terry Smith; Shu-Wan Kau; Judy M McConathy; Francisco J Esteva; Henry M Kuerer; W Fraser Symmans; Aman U Buzdar; Gabriel N Hortobagyi; Lajos Pusztai
Correlation between HER-2 expression and response to neoadjuvant chemotherapy with 5-fluorouracil, doxorubicin, and cyclophosphamide in patients with breast carcinoma.
Cancer 2003;97(7):1758-65.
2003: Lajos Pusztai; Christos Sotiriou; Thomas Buchholz; Funda Meric; W Fraser Symmans; Francisco J Esteva; Aysegul Sahin; Edison Liu; Gabriel N Hortobagi
Molecular profiles of invasive mucinous and ductal carcinomas of the breast: a molecular case study.
Cancer genetics and cytogenetics 2003;141(2):148-53.
2003: Leslie K Diaz; Kelly Hunt; Frederick C Ames; Funda Meric; Henry M Kuerer; Gildy V Babiera; Merrick Ross; Eva Singletary; Lavinia P Middleton; W Fraser Symmans; Savitri Krishnamurthy; Aysegul Sahin; Nour Sneige; Michael Z Gilcrease
Histologic localization of sentinel lymph node metastases in breast cancer.
The American journal of surgical pathology 2003;27(3):385-9.
2003: Jeffrey S Ross; Jonathan A Fletcher; Gerald P Linette; James Stec; Edward Clark; Mark Ayers; W Fraser Symmans; Lajos Pusztai; Kenneth J Bloom
The Her-2/neu gene and protein in breast cancer 2003: biomarker and target of therapy.
The oncologist 2003;8(4):307-25.
2003: Thomas Buchholz; Darren W Davis; David J McConkey; W Fraser Symmans; Vicente Valero; Anuja Jhingran; Susan L Tucker; Lajos Pusztai; Massimo Cristofanilli; Francisco J Esteva; Gabriel N Hortobagyi; Aysegul A Sahin
Chemotherapy-induced apoptosis and Bcl-2 levels correlate with breast cancer response to chemotherapy.
Cancer journal (Sudbury, Mass.) 2003;9(1):33-41.
2002: Thomas Buchholz; David N Stivers; James Stec; Mark Ayers; Edward Clark; Bolt Andrew; Aysegul A Sahin; W Fraser Symmans; Kenneth R Hess; Henry M Kuerer; Vicente Valero; Gabriel N Hortobagyi; Lajos Pusztai
Global gene expression changes during neoadjuvant chemotherapy for human breast cancer.
Cancer journal (Sudbury, Mass.) 2002;8(6):461-8.
2002: Valerie Dunmire; Chunlei Wu; W Fraser Symmans; Wei Zhang
Increased yield of total RNA from fine-needle aspirates for use in expression microarray analysis.
BioTechniques 2002;33(4):890-2, 894, 896.
2002: Andrea Lee; Savitri Krishnamurthy; Aysegul Sahin; W Fraser Symmans; Kelly Hunt; Nour Sneige
Intraoperative touch imprint of sentinel lymph nodes in breast carcinoma patients.
Cancer 2002;96(4):225-31.
2002: Steven J Kronowitz; David W Chang; Geoffrey L Robb; Kelly K Hunt; Frederick C Ames; Merrick I Ross; S Eva Singletary; W Fraser Symmans; Stephen S Kroll; Henry M Kuerer
Implications of axillary sentinel lymph node biopsy in immediate autologous breast reconstruction.
Plastic and reconstructive surgery 2002;109(6):1888-96.