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Juhani Syväoja

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Valentina Aria; Mariarita De Felice; Roberta Di Perna; Ulrich Hübscher; Hisao Masai; Juhani E Syväoja; Shuji Uno; Barbara van Loon; Francesca M Pisani
The Human Tim-Tipin Complex Interacts Directly with DNA Polymerase {epsilon} and Stimulates Its Synthetic Activity.
Seiki Nakao; Peter Karran; Marietta Y Lee; Juhani E Syväoja; Toshiki Tsurimoto; Markku Vaara; Sufang Zhang; Shinya Oda
Efficient long DNA gap-filling in a mammalian cell-free system: a potential new in vitro DNA replication assay.
Markku Vaara; Tomi Hillukkala; Harri Itkonen; Zhe Liu; Heinz Nasheuer; Helmut Pospiech; Daniel Schaarschmidt; Juhani E Syväoja
Segregation of replicative DNA polymerases during S phase: DNA polymerase ε, but not DNA polymerases α/δ, are associated with lamins throughout S phase in human cells.

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All Publications

2013: Valentina Aria; Mariarita De Felice; Roberta Di Perna; Ulrich Hübscher; Hisao Masai; Juhani E Syväoja; Shuji Uno; Barbara van Loon; Francesca M Pisani
The Human Tim-Tipin Complex Interacts Directly with DNA Polymerase {epsilon} and Stimulates Its Synthetic Activity.
The Journal of biological chemistry 2013;288(18):12742-52.
2013: Seiki Nakao; Peter Karran; Marietta Y Lee; Juhani E Syväoja; Toshiki Tsurimoto; Markku Vaara; Sufang Zhang; Shinya Oda
Efficient long DNA gap-filling in a mammalian cell-free system: a potential new in vitro DNA replication assay.
Biochimie 2013;95(2):320-8.
2012: Markku Vaara; Tomi Hillukkala; Harri Itkonen; Zhe Liu; Heinz Nasheuer; Helmut Pospiech; Daniel Schaarschmidt; Juhani E Syväoja
Segregation of replicative DNA polymerases during S phase: DNA polymerase ε, but not DNA polymerases α/δ, are associated with lamins throughout S phase in human cells.
The Journal of biological chemistry 2012;287(40):33327-38.
2011: Giuseppe Villani; Giulia di Cicco; Nadege Gironis; Ulrich Hubscher; Enni Markkanen; Sinikka Parkkinen; Helmut Pospiech; Igor Shevelev; Juhani E Syväoja; Nicolas Tanguy Le Gac
In vitro gap-directed translesion DNA synthesis of an abasic site involving human DNA polymerases epsilon, lambda, and beta.
The Journal of biological chemistry 2011;286(37):32094-104.
2010: Giada A Locatelli; Helmut Pospiech; Nicolas Tanguy Le Gac; Barbara van Loon; Ulrich Hubscher; Sinikka Parkkinen; Juhani E Syväoja; Giuseppe Villani
Effect of 8-oxoguanine and abasic site DNA lesions on in vitro elongation by human DNA polymerase in the presence of replication protein A and proliferating-cell nuclear antigen.
The Biochemical journal 2010;429(3):573-82.
2010: Qi Zhou; Tuomo Lehtonen; Jaana Lehtonen; Susana Laakso; Janusz Szymas; Helmut Pospiech; Kirsi Huoponen; Juhani E Syväoja; Yrjö Collan
Genomic analysis of the 55 kDa subunit of DNA polymerase epsilon in human intracranial neoplasms.
Cancer genomics & proteomics 2010;7(3):143-6.
2010: Miiko Sokka; Sinikka Parkkinen; Helmut Pospiech; Juhani E Syväoja
Function of TopBP1 in genome stability.
Sub-cellular biochemistry 2010;50():119-41.
2009: Qi Zhou; Kati Talvinen; J Sundström; Adam Ibrahim Elzagheid; Helmut Pospiech; Juhani E Syväoja; Yrjö Collan
Mutations/polymorphisms in the 55 kDa subunit of DNA polymerase epsilon in human colorectal cancer.
Cancer genomics & proteomics 2009;6(6):297-304.
2008: Qi Zhou; Reza Effati; Kati Talvinen; Helmut Pospiech; Juhani E Syväoja; Yrjö Collan
Genomic changes of the 55 kDa subunit of DNA polymerase epsilon in human breast cancer.
Cancer genomics & proteomics 2008;5(5):287-92.
2006: Anna K Rytkönen; Tomi Hillukkala; Markku Vaara; Miiko Sokka; Maarit Jokela; Raija Sormunen; Heinz Nasheuer; Tamar Nethanel; Gabriel Kaufmann; Helmut Pospiech; Juhani E Syväoja
DNA polymerase epsilon associates with the elongating form of RNA polymerase II and nascent transcripts.
The FEBS journal 2006;273(24):5535-49.
2006: Peeter Karihtala; Robert Winqvist; Juhani E Syväoja; Vuokko L Kinnula; Ylermi Soini
Increasing oxidative damage and loss of mismatch repair enzymes during breast carcinogenesis.
European journal of cancer (Oxford, England : 1990) 2006;42(15):2653-9.
2006: Sanna-Maria Karppinen; Hannele Erkko; Kaarina Reini; Helmut Pospiech; Katri Heikkinen; Katrin Rapakko; Juhani E Syväoja; Robert Winqvist
Identification of a common polymorphism in the TopBP1 gene associated with hereditary susceptibility to breast and ovarian cancer.
European journal of cancer (Oxford, England : 1990) 2006;42(15):2647-52.
2006: Anna K Rytkönen; Markku Vaara; Tamar Nethanel; Gabriel Kaufmann; Raija Sormunen; Esa Läärä; Heinz Nasheuer; Amal Rahmeh; Marietta Y W T Lee; Juhani E Syväoja; Helmut Pospiech
Distinctive activities of DNA polymerases during human DNA replication.
The FEBS journal 2006;273(13):2984-3001.
2006: Mika Lännenpää; Juhani E Syväoja
Device for handling electron microscopy grids.
BioTechniques 2006;40(4):450, 452.
2005: Maarit Jokela; Mari Raki; Katri Heikkinen; Katri Sepponen; Anitta Eskelinen; Juhani E Syväoja
The screening of expression and purification conditions for replicative DNA polymerase associated B-subunits, assignment of the exonuclease activity to the C-terminus of archaeal pol D DP1 subunit.
Protein expression and purification 2005;43(1):73-84.
2004: Kaarina Reini; Lahja Uitto; David Perera; Peter B Moens; Raimundo Freire; Juhani E Syväoja
TopBP1 localises to centrosomes in mitosis and to chromosome cores in meiosis.
Chromosoma 2004;112(7):323-30.
2004: David Perera; Livia Perez-Hidalgo; Peter B Moens; Kaarina Reini; Nicholas Lakin; Juhani E Syväoja; Pedro A San-Segundo; Raimundo Freire
TopBP1 and ATR colocalization at meiotic chromosomes: role of TopBP1/Cut5 in the meiotic recombination checkpoint.
Molecular biology of the cell 2004;15(4):1568-79.
2004: Maarit Jokela; Anitta Eskelinen; Helmut Pospiech; Juha Rouvinen; Juhani E Syväoja
Characterization of the 3' exonuclease subunit DP1 of Methanococcus jannaschii replicative DNA polymerase D.
Nucleic acids research 2004;32(8):2430-40.
2003: Helmut Pospiech; Juhani E Syväoja
DNA polymerase epsilon - more than a polymerase.
TheScientificWorldJournal 2003;3():87-104.
2001: M Mäkiniemi; Tomi Hillukkala; Jussi T Tuusa; Kaarina Reini; Markku Vaara; D Huang; Helmut Pospiech; I Majuri; Thomas Westerling; Tomi Mäkelä; Juhani E Syväoja
BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.
The Journal of biological chemistry 2001;276(32):30399-406.
2001: Helmut Pospiech; Anna K Rytkönen; Juhani E Syväoja
The role of DNA polymerase activity in human non-homologous end joining.
Nucleic acids research 2001;29(15):3277-88.
2001: D Huang; Maarit Jokela; Jussi T Tuusa; S Skog; K Poikonen; Juhani E Syväoja
E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase epsilon B-subunit gene POLE2.
Nucleic acids research 2001;29(13):2810-21.
2000: Ulrich Hübscher; Heinz Nasheuer; Juhani E Syväoja
Eukaryotic DNA polymerases, a growing family.
Trends in biochemical sciences 2000;25(3):143-7.
2000: S J Araújo; F Tirode; Frédéric Coin; Helmut Pospiech; Juhani E Syväoja; M Stucki; U Hübscher; Jean-Marc Egly; Richard D Wood
Nucleotide excision repair of DNA with recombinant human proteins: definition of the minimal set of factors, active forms of TFIIH, and modulation by CAK.
Genes & development 2000;14(3):349-59.
1999: Helmut Pospiech; Inari Kursula; Waleed Abdel-Aziz; Linda H Malkas; Lahja Uitto; M Kastelli; M Vihinen-Ranta; Sinikka Eskelinen; Juhani E Syväoja
A neutralizing antibody against human DNA polymerase epsilon inhibits cellular but not SV40 DNA replication.
Nucleic acids research 1999;27(19):3799-804.
1999: D Huang; R Knuuti; Heidi Palosaari; Helmut Pospiech; Juhani E Syväoja
cDNA and structural organization of the gene Pole1 for the mouse DNA polymerase epsilon catalytic subunit.
Biochimica et biophysica acta 1999;1445(3):363-71.
1999: Tapio Kesti; Karin Flick; S Keränen; Juhani E Syväoja; Curt Wittenberg
DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viability.
Molecular cell 1999;3(5):679-85.
1999: D Huang; Helmut Pospiech; Tapio Kesti; Juhani E Syväoja
Structural organization and splice variants of the POLE1 gene encoding the catalytic subunit of human DNA polymerase epsilon.
The Biochemical journal 1999;339 ( Pt 3)():657-65.
1999: M Mäkiniemi; Helmut Pospiech; SH Kilpeläinen; Maarit Jokela; Mauno Vihinen; Juhani E Syväoja
A novel family of DNA-polymerase-associated B subunits.
Trends in biochemical sciences 1999;24(1):14-6.
1998: Maarit Jokela; M Mäkiniemi; Siri T Lehtonen; Claude Szpirer; U Hellman; Juhani E Syväoja
The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon.
Nucleic acids research 1998;26(3):730-4.
1997: D Kamel; Zachary B Mackey; T Sjöblom; Christi A Walter; John R McCarrey; Lahja Uitto; Heidi Palosaari; Jaana Lähdetie; Alan E Tomkinson; Juhani E Syväoja
Role of deoxyribonucleic acid polymerase epsilon in spermatogenesis in mice.
Biology of reproduction 1997;57(6):1367-74.
1996: T Zlotkin; Gabriel Kaufmann; Y Jiang; M Y Lee; L Uitto; Juhani E Syväoja; I Dornreiter; Ellen Fanning; T Nethanel
DNA polymerase epsilon may be dispensable for SV40- but not cellular-DNA replication.
The EMBO journal 1996;15(9):2298-305.
1995: J Tuusa; Lahja Uitto; Juhani E Syväoja
Human DNA polymerase epsilon is expressed during cell proliferation in a manner characteristic of replicative DNA polymerases.
Nucleic acids research 1995;23(12):2178-83.
1995: Lahja Uitto; Jussi M Halleen; Teuvo A Hentunen; M Höyhtyä; Juhani E Syväoja
Structural relationship between DNA polymerases epsilon and epsilon* and their occurrence in eukaryotic cells.
Nucleic acids research 1995;23(2):244-7.
1994: Josiane Szpirer; F Pedeutour; Tapio Kesti; M Riviere; Juhani E Syväoja; C Turc-Carel; Claude Szpirer
Localization of the gene for DNA polymerase epsilon (POLE) to human chromosome 12q24.3 and rat chromosome 12 by somatic cell hybrid panels and fluorescence in situ hybridization.
Genomics 1994;20(2):223-6.
1993: Tapio Kesti; H Frantti; Juhani E Syväoja
Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon.
The Journal of biological chemistry 1993;268(14):10238-45.
1992: Lahja Uitto; Jussi M Halleen; P Remes; Tapio Kesti; Juhani E Syväoja
The 3'-->5' exonuclease associated with HeLa DNA polymerase epsilon.
Chromosoma 1992;102(1 Suppl):S142-6.
1991: Tapio Kesti; Juhani E Syväoja
Identification and tryptic cleavage of the catalytic core of HeLa and calf thymus DNA polymerase epsilon.
The Journal of biological chemistry 1991;266(10):6336-41.
1990: Juhani E Syväoja
DNA polymerase epsilon: the latest member in the family of mammalian DNA polymerases.
BioEssays : news and reviews in molecular, cellular and developmental biology 1990;12(11):533-6.
1987: Juhani E Syväoja
The effects of DNA polymerase I and nucleotides on ligation of hydrogen-bonded lambda DNA circles by Escherichia coli DNA ligase.
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 1987;41(7):551-4.
1987: Juhani E Syväoja
ATP-stimulated polymerase activity involving DNA polymerase I and a recB-dependent factor in extracts of Escherichia coli cells.
Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry 1987;41(5):332-5.