Thomas Szekeres

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Stark Nicole; Gridling Manuela; Madlener Sibylle; Bauer Sabine; Lackner Andreas; Popescu Ruxandra; Diaz Rene; Tut Foster M; Vo Thanh-Phuong Nha; Vonach Caroline; Giessrigl Benedikt; Saiko Philipp; Grusch Michael; Fritzer-Szekeres Monika; Szekeres Thomas; Kopp Brigitte; Frisch Richard; Krupitza Georg
A polar extract of the Maya healing plant Anthurium schlechtendalii (Aracea) exhibits strong in vitro anticancer activity.
Ozmen Ali; Bauer Sabine; Gridling Manuela; Singhuber Judith; Krasteva Stanimira; Madlener Sibylle; Vo Than Phuong Nha; Stark Nicole; Saiko Philipp; Fritzer-Szekeres Monika; Szekeres Thomas; Askin-Celik Tülay; Krenn Liselotte; Krupitza Georg
In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey.
Bernhaus Astrid; Ozsvar-Kozma Maria; Saiko Philipp; Jaschke Margit; Lackner Andreas; Grusch Michael; Horvath Zsuzsanna; Madlener Sibylle; Krupitza Georg; Handler Norbert; Erker Thomas; Jaeger Walter; Fritzer-Szekeres Monika; Szekeres Thomas
Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells.

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2009: Stark Nicole; Gridling Manuela; Madlener Sibylle; Bauer Sabine; Lackner Andreas; Popescu Ruxandra; Diaz Rene; Tut Foster M; Vo Thanh-Phuong Nha; Vonach Caroline; Giessrigl Benedikt; Saiko Philipp; Grusch Michael; Fritzer-Szekeres Monika; Szekeres Thomas; Kopp Brigitte; Frisch Richard; Krupitza Georg
A polar extract of the Maya healing plant Anthurium schlechtendalii (Aracea) exhibits strong in vitro anticancer activity.
International journal of molecular medicine 2009;24(4):513-21.
2009: Ozmen Ali; Bauer Sabine; Gridling Manuela; Singhuber Judith; Krasteva Stanimira; Madlener Sibylle; Vo Than Phuong Nha; Stark Nicole; Saiko Philipp; Fritzer-Szekeres Monika; Szekeres Thomas; Askin-Celik Tülay; Krenn Liselotte; Krupitza Georg
In vitro anti-neoplastic activity of the ethno-pharmaceutical plant Hypericum adenotrichum Spach endemic to Western Turkey.
Oncology reports 2009;22(4):845-52.
2009: Bernhaus Astrid; Ozsvar-Kozma Maria; Saiko Philipp; Jaschke Margit; Lackner Andreas; Grusch Michael; Horvath Zsuzsanna; Madlener Sibylle; Krupitza Georg; Handler Norbert; Erker Thomas; Jaeger Walter; Fritzer-Szekeres Monika; Szekeres Thomas
Antitumor effects of KITC, a new resveratrol derivative, in AsPC-1 and BxPC-3 human pancreatic carcinoma cells.
Investigational new drugs 2009;27(5):393-401.
2009: Miksits Michaela; Wlcek Katrin; Svoboda Martin; Kunert Olaf; Haslinger Ernst; Thalhammer Theresia; Szekeres Thomas; Jäger Walter
Antitumor activity of resveratrol and its sulfated metabolites against human breast cancer cells.
Planta medica 2009;75(11):1227-30.
2009: Heffeter P; Popovic-Bijelic A; Saiko P; Dornetshuber R; Jungwirth U; Voevodskaya N; Biglino D; Jakupec M A; Elbling L; Micksche M; Szekeres T; Keppler B K; Gräslund A; Berger W
Ribonucleotide reductase as one important target of [Tris(1,10-phenanthroline)lanthanum(III)] trithiocyanate (KP772).
Current cancer drug targets 2009;9(5):595-607.
2009: Gridling Manuela; Stark Nicole; Madlener Sibylle; Lackner Andreas; Popescu Ruxandra; Benedek Birgit; Diaz Rene; Tut Foster M; Nha Vo Thanh Phuong; Huber Daniela; Gollinger Michaela; Saiko Philipp; Ozmen Ali; Mosgoeller Wilhelm; De Martin Rainer; Eytner Ruth; Wagner Karl-Heinz; Grusch Michael; Fritzer-Szekeres Monika; Szekeres Thomas; Kopp Brigitte; Frisch Richard; Krupitza Georg
In vitro anti-cancer activity of two ethno-pharmacological healing plants from Guatemala Pluchea odorata and Phlebodium decumanum.
International journal of oncology 2009;34(4):1117-28.
2009: Saiko Philipp; Ozsvar-Kozma Maria; Graser Geraldine; Lackner Andreas; Grusch Michael; Madlener Sibylle; Krupitza Georg; Jaeger Walter; Hidvegi Mate; Agarwal Ram P; Fritzer-Szekeres Monika; Szekeres Thomas
Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis.
Oncology reports 2009;21(3):787-91.
2009: Miksits Michaela; Sulyok Michael; Schuhmacher Rainer; Szekeres Thomas; Jäger Walter
In-vitro sulfation of piceatannol by human liver cytosol and recombinant sulfotransferases.
The Journal of pharmacy and pharmacology 2009;61(2):185-91.
2009: Bernhaus Astrid; Fritzer-Szekeres Monika; Grusch Michael; Saiko Philipp; Krupitza Georg; Venkateswarlu Somepalli; Trimurtulu Golakoti; Jaeger Walter; Szekeres Thomas
Digalloylresveratrol, a new phenolic acid derivative induces apoptosis and cell cycle arrest in human HT-29 colon cancer cells.
Cancer letters 2009;274(2):299-304.
2008: Fritzer-Szekeres Monika; Savinc Ivo; Horvath Zsuzsanna; Saiko Philipp; Pemberger Michael; Graser Geraldine; Bernhaus Astrid; Ozsvar-Kozma Maria; Grusch Michael; Jaeger Walter; Szekeres Thomas
Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells--synergism with Ara-C.
International journal of oncology 2008;33(4):887-92.
2008: Adlbrecht Christopher; Kommata Spyridoula; Hülsmann Martin; Szekeres Thomas; Bieglmayer Christian; Strunk Guido; Karanikas Georgios; Berger Rudolf; Mörtl Deddo; Kletter Kurt; Maurer Gerald; Lang Irene M; Pacher Richard
Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body's red cell volume.
European heart journal 2008;29(19):2343-50.
2008: Murias Marek; Luczak Michal W; Niepsuj Anna; Krajka-Kuzniak Violetta; Zielinska-Przyjemska Malgorzata; Jagodzinski Pawel P; Jäger Walter; Szekeres Thomas; Jodynis-Liebert Jadwiga
Cytotoxic activity of 3,3',4,4',5,5'-hexahydroxystilbene against breast cancer cells is mediated by induction of p53 and downregulation of mitochondrial superoxide dismutase.
Toxicology in vitro : an international journal published in association with BIBRA 2008;22(5):1361-70.
2008: Cappellacci Loredana; Franchetti Palmarisa; Vita Patrizia; Petrelli Riccardo; Lavecchia Antonio; Jayaram Hiremagalur N; Saiko Philipp; Graser Geraldine; Szekeres Thomas; Grifantini Mario
Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.
Journal of medicinal chemistry 2008;51(14):4260-9.
2008: Saiko Philipp; Pemberger Michael; Horvath Zsuzsanna; Savinc Ivo; Grusch Michael; Handler Norbert; Erker Thomas; Jaeger Walter; Fritzer-Szekeres Monika; Szekeres Thomas
Novel resveratrol analogs induce apoptosis and cause cell cycle arrest in HT29 human colon cancer cells: inhibition of ribonucleotide reductase activity.
Oncology reports 2008;19(6):1621-6.
2008: Maier-Salamon Alexandra; Hagenauer Birigt; Reznicek Gottfried; Szekeres Thomas; Thalhammer Theresia; Jäger Walter
Metabolism and disposition of resveratrol in the isolated perfused rat liver: role of Mrp2 in the biliary excretion of glucuronides.
Journal of pharmaceutical sciences 2008;97(4):1615-28.
2008: Bader Yvonne; Madlener Sibylle; Strasser Stephan; Maier Susanne; Saiko Philipp; Stark Nicole; Popescu Ruxandra; Huber Daniela; Gollinger Michaela; Erker Thomas; Handler Norbert; Szakmary Akos; Jäger Walter; Kopp Brigitte; Tentes Ioannis; Fritzer-Szekeres Monika; Krupitza Georg; Szekeres Thomas
Stilbene analogues affect cell cycle progression and apoptosis independently of each other in an MCF-7 array of clones with distinct genetic and chemoresistant backgrounds.
Oncology reports 2008;19(3):801-10.
2008: Murias Marek; Miksits Michaela; Aust Sylvia; Spatzenegger Margit; Thalhammer Theresia; Szekeres Thomas; Jaeger Walter
Metabolism of resveratrol in breast cancer cell lines: impact of sulfotransferase 1A1 expression on cell growth inhibition.
Cancer letters 2008;261(2):172-82.
2008: Bader Yvonne; Hartmann Johannes; Horvath Zsuzsanna; Saiko Philipp; Grusch Michael; Madlener Sibylle; Maier Susanne; Oehler Leopold; Fritzer-Szekeres Monika; Heller Nicole; Alken Rudolf-Giesbert; Krupitza Georg; Szekeres Thomas
Synergistic effects of deuterium oxide and gemcitabine in human pancreatic cancer cell lines.
Cancer letters 2008;259(2):231-9.
2008: Saiko Philipp; Szakmary Akos; Jaeger Walter; Szekeres Thomas
Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?
Mutation research 2008;658(1-2):68-94.
2007: Zorn Carina; Szekeres Thomas; Keilani Mohammad; Fialka-Moser Veronika; Crevenna Richard
Effects of neuromuscular electrical stimulation of the knee extensor muscles on muscle soreness and different serum parameters in young male athletes: preliminary data.
British journal of sports medicine 2007;41(12):914-6.
2007: Saiko Philipp; Ozsvar-Kozma Maria; Bernhaus Astrid; Jaschke Margit; Graser Geraldine; Lackner Andreas; Grusch Michael; Horvath Zsuzsanna; Madlener Sibylle; Krupitza Georg; Handler Norbert; Erker Thomas; Jaeger Walter; Fritzer-Szekeres Monika; Szekeres Thomas
N-hydroxy-N'-(3,4,5-trimethoxyphenyl)-3,4,5-trimethoxy-benzamidine, a novel resveratrol analog, inhibits ribonucleotide reductase in HL-60 human promyelocytic leukemia cells: synergistic antitumor activity with arabinofuranosylcytosine.
International journal of oncology 2007;31(5):1261-6.
2007: Meyer Brigitte; Huelsmann Martin; Wexberg Paul; Delle Karth Georg; Berger Rudolf; Moertl Deddo; Szekeres Thomas; Pacher Richard; Heinz Gottfried
N-terminal pro-B-type natriuretic peptide is an independent predictor of outcome in an unselected cohort of critically ill patients.
Critical care medicine 2007;35(10):2268-73.
2007: Horvath Zsuzsanna; Marihart-Fazekas Sybille; Saiko Philipp; Grusch Michael; Ozsüy Mehmet; Harik Mike; Handler Norbert; Erker Thomas; Jaeger Walter; Fritzer-Szekeres Monika; Djavan Bob; Szekeres Thomas
Novel resveratrol derivatives induce apoptosis and cause cell cycle arrest in prostate cancer cell lines.
Anticancer research 2007;27(5A):3459-64.
2007: Saiko Philipp; Ozsvar-Kozma Maria; Madlener Sibylle; Bernhaus Astrid; Lackner Andreas; Grusch Michael; Horvath Zsuzsanna; Krupitza Georg; Jaeger Walter; Ammer Kirsten; Fritzer-Szekeres Monika; Szekeres Thomas
Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells.
Cancer letters 2007;250(2):323-8.
2007: Madlener Sibylle; Illmer Christoph; Horvath Zsuzsanna; Saiko Philipp; Losert Annemarie; Herbacek Irene; Grusch Michael; Elford Howard L; Krupitza Georg; Bernhaus Astrid; Fritzer-Szekeres Monika; Szekeres Thomas
Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells.
Cancer letters 2007;245(1-2):156-62.
2007: Rauko P; Novotny L; Mego M; Saiko P; Schott H; Szekeres T
In vitro and in vivo antileukemic effect of novel dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine.
Neoplasma 2007;54(1):68-74.
2006: Strasser Stephen; Maier Susanne; Leisser Christina; Saiko Philipp; Madlener Sibylle; Bader Yvonne; Bernhaus Astrid; Gueorguieva Marieta; Richter Susanne; Mader Robert M; Wesierska-Gadek Jozefa; Schott Herbert; Szekeres Thomas; Fritzer-Szekeres Monika; Krupitza Georg
5-FdUrd-araC heterodinucleoside re-establishes sensitivity in 5-FdUrd- and AraC-resistant MCF-7 breast cancer cells overexpressing ErbB2.
Differentiation; research in biological diversity 2006;74(9-10):488-98.
2006: Horvath Zsuzsanna; Murias Marek; Saiko Philipp; Erker Thomas; Handler Norbert; Madlener Sibylle; Jaeger Walter; Grusch Michael; Fritzer-Szekeres Monika; Krupitza Georg; Szekeres Thomas
Cytotoxic and biochemical effects of 3,3',4,4',5,5'-hexahydroxystilbene, a novel resveratrol analog in HL-60 human promyelocytic leukemia cells.
Experimental hematology 2006;34(10):1377-84.
2006: Maier-Salamon Alexandra; Hagenauer Birgit; Wirth Michael; Gabor Franz; Szekeres Thomas; Jäger Walter
Increased transport of resveratrol across monolayers of the human intestinal Caco-2 cells is mediated by inhibition and saturation of metabolites.
Pharmaceutical research 2006;23(9):2107-15.
2006: Ovesná Zdenka; Kozics Katarína; Bader Yvonne; Saiko Philipp; Handler Norbert; Erker Thomas; Szekeres Thomas
Antioxidant activity of resveratrol, piceatannol and 3,3',4,4',5,5'-hexahydroxy-trans-stilbene in three leukemia cell lines.
Oncology reports 2006;16(3):617-24.
2006: Maier S; Strasser S; Saiko P; Leisser C; Sasgary S; Grusch M; Madlener S; Bader Y; Hartmann J; Schott H; Mader R M; Szekeres T; Fritzer-Szekeres M; Krupitza G
Analysis of mechanisms contributing to AraC-mediated chemoresistance and re-establishment of drug sensitivity by the novel heterodinucleoside phosphate 5-FdUrd-araC.
Apoptosis : an international journal on programmed cell death 2006;11(3):427-40.
2006: Novotny Ladislav; Rauko Peter; Liska Jan; Elford Howard L; Szekeres Thomas
Potentiation of the activity of cisplatin and cyclophosphamide by trimidox, a novel ribonucleotide reductase inhibitor, in leukemia-bearing mice.
Cancer letters 2006;233(1):178-84.
2006: Horvath Z; Saiko P; Illmer C; Madlener S; Hoechtl T; Bauer W; Erker T; Jaeger W; Fritzer-Szekeres M; Szekeres T
Resveratrol, an ingredient of wine, acts synergistically with Ara-C and tiazofurin in HL-60 human promyelocytic leukemia cells.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1019-24.
2006: Saiko P; Horvath Z; Murias M; Handler N; Jaeger W; Erker T; Fritzer-Szekeres M; Szekeres T
Antitumor effects of 3,3',4,4',5,5'-hexahydroxystilbene in HL-60 human promyelocytic leukemia cells.
Nucleosides, nucleotides & nucleic acids 2006;25(9-11):1013-7.
2005: Miksits M; Maier-Salamon A; Aust S; Thalhammer T; Reznicek G; Kunert O; Haslinger E; Szekeres T; Jaeger W
Sulfation of resveratrol in human liver: evidence of a major role for the sulfotransferases SULT1A1 and SULT1E1.
Xenobiotica; the fate of foreign compounds in biological systems 2005;35(12):1101-19.
2005: Hartmann Johannes; Bader Yvonne; Horvath Zsuzsanna; Saiko Philipp; Grusch Michael; Illmer Christoph; Madlener Sibylle; Fritzer-Szekeres Monika; Heller Nicole; Alken Rudolf-Giesbert; Szekeres Thomas
Effects of heavy water (D2O) on human pancreatic tumor cells.
Anticancer research 2005;25(5):3407-11.
2005: Franchetti Palmarisa; Cappellacci Loredana; Pasqualini Michela; Petrelli Riccardo; Vita Patrizia; Jayaram Hiremagalur N; Horvath Zsuzsanna; Szekeres Thomas; Grifantini Mario
Antitumor activity of C-methyl-beta-D-ribofuranosyladenine nucleoside ribonucleotide reductase inhibitors.
Journal of medicinal chemistry 2005;48(15):4983-9.
2005: Saiko Philipp; Horvath Zsuzsanna; Illmer Christoph; Madlener Sibylle; Bauer Wolfgang; Hoechtl Thomas; Erlach Natascha; Grusch Michael; Krupitza Georg; Mader Robert M; Jaeger Walter; Schott Herbert; Agarwal Ram P; Fritzer-Szekeres Monika; Szekeres Thomas
Cytotoxic effects of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine in cross-resistant H9 human lymphoma cells.
Leukemia research 2005;29(7):785-91.
2005: Novotny Ladislav; Szekeres Thomas
Recent developments in cancer chemotherapy oriented towards new targets.
Expert opinion on therapeutic targets 2005;9(2):343-57.
2005: Szekeres Thomas; Haushofer Alexander
Clinical pharmacogenetics of immunosuppressive drugs in organ transplantation.
Pharmacogenomics 2005;6(2):163-8.
2005: Murias Marek; Jäger Walter; Handler Norbert; Erker Thomas; Horvath Zsuzsanna; Szekeres Thomas; Nohl Hans; Gille Lars
Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure-activity relationship.
Biochemical pharmacology 2005;69(6):903-12.
2005: Horvath Zsuzsanna; Saiko Philipp; Illmer Christoph; Madlener Sibylle; Hoechtl Thomas; Bauer Wolfgang; Erker Thomas; Jaeger Walter; Fritzer-Szekeres Monika; Szekeres Thomas
Synergistic action of resveratrol, an ingredient of wine, with Ara-C and tiazofurin in HL-60 human promyelocytic leukemia cells.
Experimental hematology 2005;33(3):329-35.
2005: Illmer Christoph; Madlener Sibylle; Horvath Zsuzsanna; Saiko Philipp; Losert Annemarie; Herbacek Irene; Grusch Michael; Krupitza Georg; Fritzer-Szekeres Monika; Szekeres Thomas
Immunologic and biochemical effects of the fermented wheat germ extract Avemar.
Experimental biology and medicine (Maywood, N.J.) 2005;230(2):144-9.
2005: Saiko Philipp; Horvath Zsuzsanna; Jaeger Walter; Schott Herbert; Fritzer-Szekeres Monika; Szekeres Thomas
Heterodinucleoside phosphates of 5-fluorodeoxyuridine and arabinofuranosylcytosine--new drugs in cancer chemotherapy?
In vivo (Athens, Greece) 2005;19(1):205-14.
2004: Murias Marek; Handler Norbert; Erker Thomas; Pleban Karin; Ecker Gerhard; Saiko Philipp; Szekeres Thomas; Jäger Walter
Resveratrol analogues as selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationship.
Bioorganic & medicinal chemistry 2004;12(21):5571-8.
2004: Bauer W; Horvath Z; Höchtl T; Saiko P; Karl D; Fritzer-Szekeres M; Szekeres T
Amidox, an inhibitor of ribonucleotide reductase, potentiates the action of Ara-C in HL-60 human promyelocytic leukemia cells.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1541-4.
2004: Horvath Zsuzsanna; Bauer Wolfgang; Hoechtl Thomas; Saiko Philipp; Fritzer-Szekeres Monika; Tihan Tarik; Szekeres Thomas
Combination chemotherapy of BCNU and Didox acts synergystically in 9L glioma cells.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1531-5.
2004: Saiko P; Bauer W; Horvath Z; Hoechtl T; Grusch M; Illmer C; Madlener S; Krupitza G; Mader R M; Schott H; Fritzer-Szekeres M; Szekeres T
Cytotoxic and apoptotic effects of novel heterodinucleoside phosphates consisting of 5-fluorodeoxyuridine and Ara-C in human cancer cell lines.
Nucleosides, nucleotides & nucleic acids 2004;23(8-9):1507-11.
2004: Saiko Philipp; Horvath Zsuzsanna; Bauer Wolfgang; Hoechtl Thomas; Grusch Michael; Krupitza Georg; Rauko Peter; Mader Robert M; Jaeger Walter; Schott Herbert; Novotny Ladislav; Fritzer-Szekeres Monika; Szekeres Thomas
In vitro and in vivo antitumor activity of novel amphiphilic dimers consisting of 5-fluorodeoxyuridine and arabinofuranosylcytosine.
International journal of oncology 2004;25(2):357-64.
2004: Horvath Zsuzsanna; Höchtl Thomas; Bauer Wolfgang; Fritzer-Szekeres Monika; Elford Howard L; Szekeres Thomas; Tihan Tarik
Synergistic cytotoxicity of the ribonucleotide reductase inhibitor didox (3,4-dihydroxy-benzohydroxamic acid) and the alkylating agent carmustine (BCNU) in 9L rat gliosarcoma cells and DAOY human medulloblastoma cells.
Cancer chemotherapy and pharmacology 2004;54(2):139-45.
2004: Höchtl Thomas; Horvath Zsuzsanna; Bauer Wolfgang; Karl Doris; Saiko Philipp; Elford Howard L; Fritzer-Szekeres Monika; Szekeres Thomas
Biochemical modulation of Ara-C effects by amidox, an inhibitor of ribonucleotide reductase in HL-60 promyelocytic human leukemia cells.
Life sciences 2004;74(9):1071-80.
2003: Rauko Peter; Bauer Wolfgang; Horvath Zsuzsanna; Höchtl Thomas; Saiko Philipp; Karl Doris; Schott Herbert; Fritzer-Szekeres Monika; Novotny Ladislav; Szekeres Thomas
Combination effects of Ara-C and 5-fluorodeoxyuridine against leukemia cells in vitro and in mice.
Anticancer research 2003;23(5A):3841-6.
2003: Lhotka Christian; Szekeres Thomas; Steffan Ilse; Zhuber Klaus; Zweymüller Karl
Four-year study of cobalt and chromium blood levels in patients managed with two different metal-on-metal total hip replacements.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2003;21(2):189-95.
2002: Fritzer-Szekeres Monika; Salamon Alexandra; Grusch Michael; Horvath Zsuzsanna; Höchtl Thomas; Steinbrugger Richard; Jäger Walter; Krupitza Georg; Elford Howard L; Szekeres Thomas
Trimidox, an inhibitor of ribonucleotide reductase, synergistically enhances the inhibition of colony formation by Ara-C in HL-60 human promyelocytic leukemia cells.
Biochemical pharmacology 2002;64(3):481-5.
2002: Szekeres Thomas; Novotny Ladislav
New targets and drugs in cancer chemotherapy.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2002;11(3):117-25.
2002: Jäger Walter; Salamon Alexandra; Szekeres Thomas
Metabolism of the novel IMP dehydrogenase inhibitor benzamide riboside.
Current medicinal chemistry 2002;9(7):781-6.
2002: Novotny Ladislav; Rauko Peter; Yalowitz Joel A; Szekeres Thomas
Antitumor activity of benzamide riboside in vitro and in vivo.
Current medicinal chemistry 2002;9(7):773-9.
2002: Szekeres Thomas; Sedlak Jan; Novotny Ladislav
Benzamide riboside, a recent inhibitor of inosine 5'-monophosphate dehydrogenase induces transferrin receptors in cancer cells.
Current medicinal chemistry 2002;9(7):759-64.
2002: Grusch M; Polgar D; Gfatter S; Leuhuber K; Huettenbrenner S; Leisser C; Fuhrmann G; Kassie F; Steinkellner H; Smid K; Peters G J; Jayaram H N; Klepal W; Szekeres T; Knasmüller S; Krupitza G
Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside.
Cell death and differentiation 2002;9(2):169-78.
2001: Salamon A; Hagenauer B; Thalhammer T; Szekeres T; Krohn K; Jayaram H N; Jäger W
Metabolism and disposition of the novel antileukaemic drug, benzamide riboside, in the isolated perfused rat liver.
Life sciences 2001;69(21):2489-502.
2001: Grusch M; Fritzer-Szekeres M; Fuhrmann G; Rosenberger G; Luxbacher C; Elford H L; Smid K; Peters G J; Szekeres T; Krupitza G
Activation of caspases and induction of apoptosis by novel ribonucleotide reductase inhibitors amidox and didox.
Experimental hematology 2001;29(5):623-32.
2001: Rauko P; Novotny L; Dovinova I; Hunakova L; Szekeres T; Jayaram H N
Antitumor activity of benzamide riboside and its combination with cisplatin and staurosporine.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;12(4):387-94.
2000: Rosenberger G; Fuhrmann G; Grusch M; Fassl S; Elford H L; Smid K; Peters G J; Szekeres T; Krupitza G
The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells.
Life sciences 2000;67(26):3131-42.
2000: Gharehbaghi K; Szekeres T; Yalowitz J A; Fritzer-Szekeres M; Pommier Y G; Jayaram H N
Sensitizing human colon carcinoma HT-29 cells to cisplatin by cyclopentenylcytosine, in vitro and in vivo.
Life sciences 2000;68(1):1-11.
2000: Hamwi A; Salomon A; Steinbrugger R; Fritzer-Szekeres M; Jäger W; Szekeres T
Cyclosporine metabolism in patients after kidney, bone marrow, heart-lung, and liver transplantation in the early and late posttransplant periods.
American journal of clinical pathology 2000;114(4):536-43.
2000: Salamon A; Vielnascher E; Hagenauer B; Szekeres T; Szekeres-Fritzer M; Thalhammer T; Jäger W
Metabolism of the new ribonucleotide reductase inhibitor amidox in the isolated perfused rat liver.
Anticancer research 2000;20(5B):3521-6.
2000: Fritzer-Szekeres M; Grusch M; Luxbacher C; Horvath S; Krupitza G; Elford H L; Szekeres T
Trimidox, an inhibitor of ribonucleotide reductase, induces apoptosis and activates caspases in HL-60 promyelocytic leukemia cells.
Experimental hematology 2000;28(8):924-30.
2000: Gharehbaghi K; Kubin A; Grusch M; Gharehbaghi-Schnell E; Wierrani F; Jayaram H N; Grunberger W; Szekeres T
Photodynamic action of meta-tetrahydroxyphenylchlorin (mTHPC) on an ovarian cancer cell line.
Anticancer research 2000;20(4):2647-52.
2000: Hamwi A; Veitl M; Maenner G; Vogelsang H; Szekeres T
Pancreatic elastase 1 in stool: variations within one stool passage and individual changes from day to day.
Wiener klinische Wochenschrift 2000;112(1):32-5.
2000: Fritzer-Szekeres M; Luxbacher C; Horvath Z; Grusch M; Krupitza G; Elford H L; Szekeres T
Apoptosis-inducing cleavage of caspases by trimidox, an inhibitor of ribonucleotide reductase.
Advances in experimental medicine and biology 2000;486():125-30.
1999: Hamwi A; Veitl M; Männer G; Ruzicka K; Schweiger C; Szekeres T
Evaluation of four automated methods for determination of whole blood cyclosporine concentrations.
American journal of clinical pathology 1999;112(3):358-65.
1999: Grusch M; Rosenberger G; Fuhrmann G; Braun K; Titscher B; Szekeres T; Fritzer-Skekeres M; Oberhuber G; Krohn K; Hengstschlaeger M; Krupitza G; Jayaram H N
Benzamide riboside induces apoptosis independent of Cdc25A expression in human ovarian carcinoma N.1 cells.
Cell death and differentiation 1999;6(8):736-44.
1999: Gharehbaghi K; Zhen W; Fritzer-Szekeres M; Szekeres T; Jayaram H N
Studies on the antitumor activity and biochemical actions of cyclopentenyl cytosine against human colon carcinoma HT-29 in vitro and in vivo.
Life sciences 1999;64(2):103-12.
1998: Lhotka C G; Szekeres T; Fritzer-Szekeres M; Schwarz G; Steffan I; Maschke M; Dubsky G; Kremser M; Zweymüller K
Are allergic reactions to skin clips associated with delayed wound healing?
American journal of surgery 1998;176(4):320-3.
1998: Fritzer-Szekeres M; Blom H J; Boers G H; Szekeres T; Lubec B
Growth promotion by homocysteine but not by homocysteic acid: a role for excessive growth in homocystinuria or proliferation in hyperhomocysteinemia?
Biochimica et biophysica acta 1998;1407(1):1-6.
1998: Hunáková L; Duraj J; Romanová D; Novotný L; Sedlák J; Kelley M R; Szekeres T; Jayaram H N; Chorváth B
Staurosporine enhanced benzamide riboside-induced apoptosis in human multidrug-resistant promyelocytic leukemia cells (HL-60/VCR) in vitro.
Neoplasma 1998;45(4):204-9.
1998: Fritzer-Szekeres M; Novotny L; Romanova D; Göbl R; Sedlak J; Vachalkova A; Rauko P; Elford H L; Szekeres T
Enhanced effects of adriamycin by combination with a new ribonucleotide reductase inhibitor, trimidox, in murine leukemia.
Life sciences 1998;63(7):545-52.
1998: Fritzer-Szekeres M; Novotny L; Vachalkova A; Göbl R; Elford H L; Szekeres T
Iron binding capacity of didox (3,4 dihydroxybenzohydroxamic acid) and amidox (3,4 dihydroxybenzamidoxime) two inhibitors of the enzyme ribonucleotide reductase.
Advances in experimental medicine and biology 1998;431():599-604.
1997: Szekeres T; Fritzer-Szekeres M; Elford H L
The enzyme ribonucleotide reductase: target for antitumor and anti-HIV therapy.
Critical reviews in clinical laboratory sciences 1997;34(6):503-28.
1997: Rauko P; Romanova D; Miadokova E; Macakova K; Novotny L; Elford H L; Szekeres T
DNA-protective activity of new ribonucleotide reductase inhibitors.
Anticancer research 1997;17(5A):3437-40.
1997: Vielnascher E; Romanová D; Novotný L; Szekeres T; Elfort H L; Thalhammer T; Jäger W
Simultaneous determination of the new anticancer agent amidox and its metabolites in rat bile and plasma by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications 1997;696(2):267-74.
1997: Romanova D; Vachalkova A; Szekeres T; Elford H L; Novotny L
The new inhibitors of ribonucleotide reductase--comparison of some physico-chemical properties.
Journal of pharmaceutical and biomedical analysis 1997;15(7):951-6.
1997: Fritzer-Szekeres M; Novotny L; Vachalkova A; Findenig G; Elford H L; Szekeres T
Iron binding capacity of didox (3,4-dihydroxybenzohydroxamic acid) and amidox (3,4-dihydroxybenzamidoxime) new inhibitors of the enzyme ribonucleotide reductase.
Life sciences 1997;61(22):2231-7.
1996: Fritzer M; Szekeres T; Szüts V; Jarayam H N; Goldenberg H
Cytotoxic effects of a doxorubicin-transferrin conjugate in multidrug-resistant KB cells.
Biochemical pharmacology 1996;51(4):489-93.
1996: Krupitza G; Grill S; Harant H; Hulla W; Szekeres T; Huber H; Dittrich C
Genes related to growth and invasiveness are repressed by sodium butyrate in ovarian carcinoma cells.
British journal of cancer 1996;73(4):433-8.
1996: Findenig G; Mader R M; Fritzer-Szekeres M; Steger G G; Jaeger W; Szekeres T
Modulation of 5-fluorouracil resistance in human colon tumor cell lines by azidothymidine.
Oncology research 1996;8(5):189-96.
1996: Schön H J; Grgurin M; Szekeres T; Schurz B
A new mode of treatment of human papilloma virus associated anogenital lesions using a nonsteroid estrogen analogue.
Wiener klinische Wochenschrift 1996;108(2):45-7.
1995: Szekeres T; Vielnascher E; Novotny L; Vachalkova A; Fritzer M; Findenig G; Göbl R; Elford H L; Goldenberg H
Iron binding capacity of trimidox (3,4,5-trihydroxybenzamidoxime), a new inhibitor of the enzyme ribonucleotide reductase.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1995;33(11):785-9.
1995: Krupitza G; Harant H; Dittrich E; Szekeres T; Huber H; Dittrich C
Sodium butyrate inhibits c-myc splicing and interferes with signal transduction in ovarian carcinoma cells.
Carcinogenesis 1995;16(5):1199-205.
1995: Findenig G; Vielnascher E; Göbl R; Fritzer-Szekeres M; Szekeres T
[The ribonucleotide reductase enzyme as a target for enzyme-directed chemotherapy effects of trimidox (3,4,5-trihydroxybenzohydroxamidoxim), a new inhibitor of ribonucleotide reductases]
Wiener klinische Wochenschrift 1995;107(22):694-7.
1994: Szekeres T; Fritzer M; Strobl H; Gharehbaghi K; Findenig G; Elford H L; Lhotka C; Schoen H J; Jayaram H N
Synergistic growth inhibitory and differentiating effects of trimidox and tiazofurin in human promyelocytic leukemia HL-60 cells.
Blood 1994;84(12):4316-21.
1994: Gharehbaghi K; Sreenath A; Hao Z; Paull K D; Szekeres T; Cooney D A; Krohn K; Jayaram H N
Comparison of biochemical parameters of benzamide riboside, a new inhibitor of IMP dehydrogenase, with tiazofurin and selenazofurin.
Biochemical pharmacology 1994;48(7):1413-9.
1994: Szekeres T; Gharehbaghi K; Fritzer M; Woody M; Srivastava A; van't Riet B; Jayaram H N; Elford H L
Biochemical and antitumor activity of trimidox, a new inhibitor of ribonucleotide reductase.
Cancer chemotherapy and pharmacology 1994;34(1):63-6.
1994: Szekeres T; Fritzer M; Schön H J; Findenig G; Lhotka C
[Synergistic cytotoxic effects of chemotherapy in colon tumor cells by simultaneous inhibition of de novo and salvage energy metabolism pathways]
Wiener klinische Wochenschrift 1994;106(14):459-63.
1993: Szekeres T; Schuchter K; Chiba P; Ressmann G; Lhotka C; Gharehbaghi K; Szalay S M; Pillwein K
Synergistic action of tiazofurin with hypoxanthine and allopurinol in human neuroectodermal tumor cell lines.
Biochemical pharmacology 1993;46(11):1903-7.
1993: Pillwein K; Schuchter K; Ressmann G; Gharehbaghi K; Knoflach A; Cermak B; Jayaram H N; Szalay S M; Szekeres T; Chiba P
Cytotoxicity, differentiating activity and metabolism of tiazofurin in human neuroblastoma cells.
International journal of cancer. Journal international du cancer 1993;55(1):92-5.
1993: Fritzer M; Gharehbaghi K; Pillwein K; Chiba P; Goldenberg H; Szekeres T
GM-CSF: modulation of biochemical and cytotoxic effects of tiazofurin in HL-60 cells.
British journal of haematology 1993;84(3):552-4.
1993: Szekeres T; Artner-Dworzak E; Puschendorf B; Fritzer M; Havel M; Gassner A; Fridrich L
Correlation of atrial natriuretic peptide and cyclic guanosine monophosphate plasma concentrations in patients with heart disorders during rest and exercise.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1993;31(2):69-74.
1993: Weber G; Singhal R L; Abonyi M; Prajda N; Hata Y; Szekeres T; Yeh A; Look K Y
Regulation of deoxycytidine kinase activity and inhibition by DFDC.
Advances in enzyme regulation 1993;33():39-59.
1992: Szekeres T; Cho-Chung Y S; Weber G
Action of tiazofurin and 8-Cl-cAMP in human colon and pancreatic cancer cells.
Cancer biochemistry biophysics 1992;13(2):67-74.
1992: Fritzer M; Barabas K; Szüts V; Berczi A; Szekeres T; Faulk W P; Goldenberg H
Cytotoxicity of a transferrin-adriamycin conjugate to anthracycline-resistant cells.
International journal of cancer. Journal international du cancer 1992;52(4):619-23.
1992: Szekeres T; Fritzer M; Pillwein K; Felzmann T; Chiba P
Cell cycle dependent regulation of IMP dehydrogenase activity and effect of tiazofurin.
Life sciences 1992;51(16):1309-15.
1992: Weber G; Nakamura H; Natsumeda Y; Szekeres T; Nagai M
Regulation of GTP biosynthesis.
Advances in enzyme regulation 1992;32():57-69.
1992: Singhal R L; Yeh Y A; Szekeres T; Weber G
Increased deoxycytidine kinase activity in cancer cells and inhibition by difluorodeoxycytidine.
Oncology research 1992;4(11-12):517-22.
1991: Chiba P; Szekeres T; Jäger W
Determination of pyrimidine deoxynucleoside triphosphates in leukaemia cell extracts containing 1-beta-D-arabinofuranosylcytosine triphosphate.
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 1991;29(6):385-9.
1991: Weber G; Nagai M; Prajda N; Nakamura H; Szekeres T; Olah E
AZT: a biochemical response modifier of methotrexate and 5-fluorouracil cytotoxicity in human ovarian and pancreatic carcinoma cells.
Cancer communications 1991;3(4):127-32.
1990: Chiba P; Tihan T; Szekeres T; Salamon J; Kraupp M; Eher R; Köller U; Knapp W
Concordant changes of pyrimidine metabolism in blasts of two cases of acute myeloid leukemia after repeated treatment with ara-C in vivo.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 1990;4(11):761-5.
1989: Fridrich L; Szekeres T; Hartter E; Schweighofer F; Gassner A; Laczkovic A
Correlation between heart disorders and concentrations of directly measured atrial natriuretic peptide in plasma.
Clinical chemistry 1989;35(3):435-9.
1986: Kraupp M; März R; Legenstein E; Knerer B; Szekeres T
Evaluation of radioimmunoassays: comparison of dose interpolation calculations by four parameter logistic and spline functions.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift für klinische Chemie und klinische Biochemie 1986;24(12):1023-8.

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