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Jacob Sznajder

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Jacob I Sznajder; Laurent Brochard; G R Scott Budinger; Serpil C Erzurum; Elliot Israel; Paul Schumacker
Process and impact as the journal moves forward.
Hanh Chi Do-Umehara; Martin Eilers; Samuel Jang; Anning Lin; Margaret A Baker; G R Scott Budinger; Cong Chen; Gökhan M Mutlu; Ju Qiu; Karen M Ridge; Peter H S Sporn; Jacob I Sznajder; Daniela Urich; Alia Zander; Liang Zhou; Jing Liu
Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ.
Emilia Lecuona; Haiying Sun; Margaret A Baker; Jiwang Chen; Humberto Trejo; Jacob I Sznajder
Protein Kinase A-Iα Regulates Na,K-ATPase Endocytosis in Alveolar Epithelial Cells Exposed to High CO2 Concentrations.

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All Publications

2013: Jacob I Sznajder; Laurent Brochard; G R Scott Budinger; Serpil C Erzurum; Elliot Israel; Paul Schumacker
Process and impact as the journal moves forward.
American journal of respiratory and critical care medicine 2013;187(9):897-8.
2013: Hanh Chi Do-Umehara; Martin Eilers; Samuel Jang; Anning Lin; Margaret A Baker; G R Scott Budinger; Cong Chen; Gökhan M Mutlu; Ju Qiu; Karen M Ridge; Peter H S Sporn; Jacob I Sznajder; Daniela Urich; Alia Zander; Liang Zhou; Jing Liu
Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ.
Nature immunology 2013;14(5):461-9.
2013: Emilia Lecuona; Haiying Sun; Margaret A Baker; Jiwang Chen; Humberto Trejo; Jacob I Sznajder
Protein Kinase A-Iα Regulates Na,K-ATPase Endocytosis in Alveolar Epithelial Cells Exposed to High CO2 Concentrations.
American journal of respiratory cell and molecular biology 2013;48(5):626-34.
2012: Jacob I Sznajder; Aaron Ciechanover
Personalized medicine: the road ahead.
American journal of respiratory and critical care medicine 2012;186(10):945-7.
2012: Kristina Eneling; Naoki Mochizuki; Maria J Pinho; Vanda Pinto; Patricio Soares-da-Silva; Jacob I Sznajder; Laura Brion; Kazuo Emoto; Alejandro M Bertorello
Salt-inducible kinase 1 regulates E-cadherin expression and intercellular junction stability.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012;26(8):3230-9.
2012: István Vadász; Rolf D Hubmayr; Nicolás Nin; Peter H S Sporn; Jacob I Sznajder
Hypercapnia: a nonpermissive environment for the lung.
American journal of respiratory cell and molecular biology 2012;46(4):417-21.
2012: Elmira Tokhtaeva; Laura A Dada; George Sachs; Haiying Sun; Jacob I Sznajder; Olga Vagin
Identification of the amino acid region involved in the intercellular interaction between the β1 subunits of Na+/K+ -ATPase.
Journal of cell science 2012;125(Pt 6):1605-16.
2012: István Vadász; Curtis H Weiss; Jacob I Sznajder
Ubiquitination and proteolysis in acute lung injury.
Chest 2012;141(3):763-71.
2012: István Vadász; Lynn C Welch; Greg J Beitel; Arturo Briva; G R Scott Budinger; Laura A Dada; Yosef Gruenbaum; Benno A Grzesik; Iiro Taneli Helenius; Aileen M Kelly; Jing Liu; Werner Seeger; Kfir Sharabi; Jacob I Sznajder
Evolutionary conserved role of c-Jun-N-terminal kinase in CO2-induced epithelial dysfunction.
PloS one 2012;7(10):e46696.
2011: Christine U Vohwinkel; István Vadász; Navdeep S Chandel; Emilia Lecuona; Natascha Sommer; Haying Sun; Jacob I Sznajder
Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation.
The Journal of biological chemistry 2011;286(43):37067-76.
2011: Galina A Gusarova; Robert B Hamanaka; Gökhan M Mutlu; Murali Prakriya; Arturo Briva; Navdeep S Chandel; Laura A Dada; Humberto Trejo; Lynn C Welch; Jacob I Sznajder
Hypoxia leads to Na,K-ATPase downregulation via Ca(2+) release-activated Ca(2+) channels and AMPK activation.
Molecular and cellular biology 2011;31(17):3546-56.
2011: Qiyuan Zhou; G R Scott Budinger; Oliver Eickelberg; Cara J Gottardi; Jonathan Jones; Melanie Königshoff; Annie Pardo; J Usha Raj; Moises Selman; Jacob I Sznajder; Krishna Thavarajah; John Varga; Guofei Zhou
Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011;25(9):3032-44.
2011: Kristina Eneling; Jiwang Chen; Lynn C Welch; Hiroshi Takemori; Jacob I Sznajder; Alejandro M Bertorello
Salt-inducible kinase 1 is present in lung alveolar epithelial cells and regulates active sodium transport.
Biochemical and biophysical research communications 2011;409(1):28-33.
2011: István Vadász; Jacob I Sznajder
Update in acute lung injury and critical care 2010.
American journal of respiratory and critical care medicine 2011;183(9):1147-52.
2011: Laura A Dada; Jacob I Sznajder
Mitochondrial Ca²+ and ROS take center stage to orchestrate TNF-α-mediated inflammatory responses.
The Journal of clinical investigation 2011;121(5):1683-5.
2010: Lynn C Welch; Emilia Lecuona; Arturo Briva; Humberto E Trejo; Laura A Dada; Jacob I Sznajder
Extracellular signal-regulated kinase (ERK) participates in the hypercapnia-induced Na,K-ATPase downregulation.
FEBS letters 2010;584(18):3985-9.
2010: Yi Yang; HanhChi Do; Xuejun Tian; Chaozheng Zhang; Xinyuan Liu; Laura A Dada; Jacob I Sznajder; Jing Liu
E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFalpha-induced JNK activation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(30):13444-9.
2010: Arturo Briva; Emilia Lecuona; Jacob I Sznajder
[Permissive and non-permissive hypercapnia: mechanisms of action and consequences of high carbon dioxide levels].
Archivos de bronconeumología 2010;46(7):378-82.
2010: Naizhen Wang; Khalilah L Gates; Humberto Trejo; Silvio Favoreto; Robert P Schleimer; Jacob I Sznajder; Greg J Beitel; Peter H S Sporn
Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(7):2178-90.
2010: Alejandro P Comellas; Aileen M Kelly; Humberto E Trejo; Arturo Briva; Joyce Lee; Jacob I Sznajder; Laura A Dada
Insulin regulates alveolar epithelial function by inducing Na+/K+-ATPase translocation to the plasma membrane in a process mediated by the action of Akt.
Journal of cell science 2010;123(Pt 8):1343-51.
2010: Iiro T Helenius; Laura A Dada; Jacob I Sznajder
Role of ubiquitination in Na,K-ATPase regulation during lung injury.
Proceedings of the American Thoracic Society 2010;7(1):65-70.
2010: Humberto E Trejo; Emilia Lecuona; Doris Grillo; Igal Szleifer; Oksana E Nekrasova; Vladimir I Gelfand; Jacob I Sznajder
Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010;24(2):374-82.
2009: Guofei Zhou; Laura A Dada; Minghua Wu; Aileen Kelly; Humberto Trejo; Qiyuan Zhou; John Varga; Jacob I Sznajder
Hypoxia-induced alveolar epithelial-mesenchymal transition requires mitochondrial ROS and hypoxia-inducible factor 1.
American journal of physiology. Lung cellular and molecular physiology 2009;297(6):L1120-30.
2009: Emilia Lecuona; Haiying Sun; Christine Vohwinkel; Aaron Ciechanover; Jacob I Sznajder
Ubiquitination participates in the lysosomal degradation of Na,K-ATPase in steady-state conditions.
American journal of respiratory cell and molecular biology 2009;41(6):671-9.
2009: Iiro Taneli Helenius; Thomas Krupinski; Douglas W Turnbull; Yosef Gruenbaum; Neal Silverman; Eric A Johnson; Peter H S Sporn; Jacob I Sznajder; Greg J Beitel
Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(44):18710-5.
2009: Kfir Sharabi; Emilia Lecuona; Iiro Taneli Helenius; Greg J Beitel; Jacob I Sznajder; Yosef Gruenbaum
Sensing, physiological effects and molecular response to elevated CO2 levels in eukaryotes.
Journal of cellular and molecular medicine 2009;13(11-12):4304-18.
2009: Emilia Lecuona; Alexander Minin; Humberto E Trejo; Jiwang Chen; Alejandro P Comellas; Haiying Sun; Doris Grillo; Oxana E Nekrasova; Lynn C Welch; Igal Szleifer; Vladimir I Gelfand; Jacob I Sznajder
Myosin-Va restrains the trafficking of Na+/K+-ATPase-containing vesicles in alveolar epithelial cells.
Journal of cell science 2009;122(Pt 21):3915-22.
2009: Galina A Gusarova; Laura A Dada; Aileen M Kelly; Chaya Brodie; Lee A Witters; Navdeep S Chandel; Jacob I Sznajder
Alpha1-AMP-activated protein kinase regulates hypoxia-induced Na,K-ATPase endocytosis via direct phosphorylation of protein kinase C zeta.
Molecular and cellular biology 2009;29(13):3455-64.
2009: Kfir Sharabi; Anat Hurwitz; Amos J Simon; Greg J Beitel; Richard I Morimoto; Gideon Rechavi; Jacob I Sznajder; Yosef Gruenbaum
Elevated CO2 levels affect development, motility, and fertility and extend life span in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(10):4024-9.
2009: Alejandro P Comellas; Arturo Briva; Laura A Dada; Maria L Butti; Humberto E Trejo; Cecilia Yshii; Zaher S Azzam; Juan Litvan; Jiwang Chen; Emilia Lecuona; Liuska Pesce; Masashi Yanagisawa; Jacob I Sznajder
Endothelin-1 impairs alveolar epithelial function via endothelial ETB receptor.
American journal of respiratory and critical care medicine 2009;179(2):113-22.
2008: Yochai Adir; Lynn C Welch; Vidas Dumasius; Phillip H. Factor; Jacob I Sznajder; Karen M Ridge
Overexpression of the Na-K-ATPase alpha2-subunit improves lung liquid clearance during ventilation-induced lung injury.
American journal of physiology. Lung cellular and molecular physiology 2008;294(6):L1233-7.
2008: Guofei Zhou; Laura A Dada; Jacob I Sznajder
Regulation of alveolar epithelial function by hypoxia.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 2008;31(5):1107-13.
2008: Guofei Zhou; Laura A Dada; Navdeep S Chandel; Kazuhiro Iwai; Emilia Lecuona; Aaron Ciechanover; Jacob I Sznajder
Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008;22(5):1335-42.
2008: István Vadász; Laura A Dada; Arturo Briva; Humberto Trejo; Lynn C Welch; Jiwang Chen; Péter T Tóth; Emilia Lecuona; Lee A Witters; Paul T Schumacker; Navdeep S Chandel; Werner Seeger; Jacob I Sznajder
AMP-activated protein kinase regulates CO2-induced alveolar epithelial dysfunction in rats and human cells by promoting Na,K-ATPase endocytosis.
The Journal of clinical investigation 2008;118(2):752-62.
2008: Jiwang Chen; Emilia Lecuona; Arturo Briva; Lynn C Welch; Jacob I Sznajder
Carbonic anhydrase II and alveolar fluid reabsorption during hypercapnia.
American journal of respiratory cell and molecular biology 2008;38(1):32-7.
2007: Emilia Lecuona; Humberto Trejo; Jacob I Sznajder
Regulation of Na,K-ATPase during acute lung injury.
Journal of bioenergetics and biomembranes 2007;39(5-6):391-5.
2007: Gökhan M Mutlu; David Green; Amy Bellmeyer; Christina M Baker; Zach Burgess; Nalini Rajamannan; John W Christman; Nancy Foiles; David W Kamp; Andrew J Ghio; Navdeep S Chandel; David A Dean; Jacob I Sznajder; G R Scott Budinger
Ambient particulate matter accelerates coagulation via an IL-6-dependent pathway.
The Journal of clinical investigation 2007;117(10):2952-61.
2007: Laura A Dada; Lynn C Welch; Guofei Zhou; Ronen Ben-Saadon; Aaron Ciechanover; Jacob I Sznajder
Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia.
Cellular signalling 2007;19(9):1893-8.
2007: Laura A Dada; Eva Novoa; Emilia Lecuona; Haiying Sun; Jacob I Sznajder
Role of the small GTPase RhoA in the hypoxia-induced decrease of plasma membrane Na,K-ATPase in A549 cells.
Journal of cell science 2007;120(Pt 13):2214-22.
2007: István Vadász; Stacy Raviv; Jacob I Sznajder
Alveolar epithelium and Na,K-ATPase in acute lung injury.
Intensive care medicine 2007;33(7):1243-51.
2007: Laura A Dada; Jacob I Sznajder
Hypoxic inhibition of alveolar fluid reabsorption.
Advances in experimental medicine and biology 2007;618():159-68.
2007: Arturo Briva; István Vadász; Emilia Lecuona; Lynn C Welch; Jiwang Chen; Laura A Dada; Humberto Trejo; Vidas Dumasius; Zaher S Azzam; Pavlos Makarios Myrianthefs; Daniel Batlle; Yosef Gruenbaum; Jacob I Sznajder
High CO2 levels impair alveolar epithelial function independently of pH.
PloS one 2007;2(11):e1238.
2006: Astrid Crespo; Eva Novoa; Daniela Urich; Humberto Trejo; Alejandro Pezzulo; Jacob I Sznajder; Fernández Livia; Roberto Sánchez de León
[Effect of changes in airway pressure and the inspiratory volume on the fluid filtration rate and pulmonary artery pressure in isolated rabbit lungs perfused with blood and acellular solution].
Investigación clínica 2006;47(4):323-35.
2006: G R Scott Budinger; Jacob I Sznajder
The alveolar-epithelial barrier: a target for potential therapy.
Clinics in chest medicine 2006;27(4):655-69; abstract ix.
2006: Emilia Lecuona; Laura A Dada; Haiying Sun; Maria L Butti; Guofei Zhou; Teng-Leong Chew; Jacob I Sznajder
Na,K-ATPase alpha1-subunit dephosphorylation by protein phosphatase 2A is necessary for its recruitment to the plasma membrane.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(14):2618-20.
2006: Zaher S Azzam; Yochai Adir; Lynn C Welch; Jiwang Chen; Joseph Winaver; Phillip H. Factor; Norberto Krivoy; Aaron Hoffman; Jacob I Sznajder; Zaid Abassi
Alveolar fluid reabsorption is increased in rats with compensated heart failure.
American journal of physiology. Lung cellular and molecular physiology 2006;291(5):L1094-100.
2006: David M Guidot; Hans Folkesson; Lucky Jain; Jacob I Sznajder; Jean-François Pittet; Michael A Matthay
Integrating acute lung injury and regulation of alveolar fluid clearance.
American journal of physiology. Lung cellular and molecular physiology 2006;291(3):L301-6.
2006: Juan Litvan; Arturo Briva; Mindy S Wilson; G R Scott Budinger; Jacob I Sznajder; Karen M Ridge
Beta-adrenergic receptor stimulation and adenoviral overexpression of superoxide dismutase prevent the hypoxia-mediated decrease in Na,K-ATPase and alveolar fluid reabsorption.
The Journal of biological chemistry 2006;281(29):19892-8.
2006: Zongpei Chen; Rafael T Krmar; Laura Dada; Riad Efendiev; Ingo B Leibiger; Carlos H Pedemonte; Adrian I Katz; Jacob I Sznajder; Alejandro M Bertorello
Phosphorylation of adaptor protein-2 mu2 is essential for Na+,K+-ATPase endocytosis in response to either G protein-coupled receptor or reactive oxygen species.
American journal of respiratory cell and molecular biology 2006;35(1):127-32.
2006: Gökhan M Mutlu; Colleen Snyder; Amy Bellmeyer; Helena Wang; Keenan Hawkins; Saul Soberanes; Lynn C Welch; Andrew J Ghio; Navdeep S Chandel; David W Kamp; Jacob I Sznajder; G R Scott Budinger
Airborne particulate matter inhibits alveolar fluid reabsorption in mice via oxidant generation.
American journal of respiratory cell and molecular biology 2006;34(6):670-6.
2006: Alejandro P Comellas; Laura A Dada; Emilia Lecuona; Liuska Pesce; Navdeep S Chandel; Nancy Quesada; G R Scott Budinger; Ger J Strous; Aaron Ciechanover; Jacob I Sznajder
Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system.
Circulation research 2006;98(10):1314-22.
2005: Alejandro M Bertorello; Jacob I Sznajder
The dopamine paradox in lung and kidney epithelia: sharing the same target but operating different signaling networks.
American journal of respiratory cell and molecular biology 2005;33(5):432-7.
2005: Gökhan M Mutlu; Jacob I Sznajder
Mechanisms of pulmonary edema clearance.
American journal of physiology. Lung cellular and molecular physiology 2005;289(5):L685-95.
2005: Karen M Ridge; Laura Linz; Frederick ('Eric') Werner Flitney; Edward R Kuczmarski; Ying-Hao Chou; Bishr Omary; Jacob I Sznajder; Robert D Goldman
Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells.
The Journal of biological chemistry 2005;280(34):30400-5.
2005: Jonathan C R Jones; Kimberly Lane; Susan B Hopkinson; Emilia Lecuona; R. Christopher Geiger; David A Dean; Eduardo Correa-Meyer; Meredith Gonzales; Kevin Campbell; Jacob I Sznajder; Scott Budinger
Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism.
Journal of cell science 2005;118(Pt 12):2557-66.
2005: Pavlos Makarios Myrianthefs; Arturo Briva; Emilia Lecuona; Vidas Dumasius; David H Rutschman; Karen M Ridge; George Baltopoulos; Jacob I Sznajder
Hypocapnic but not metabolic alkalosis impairs alveolar fluid reabsorption.
American journal of respiratory and critical care medicine 2005;171(11):1267-71.
2005: Gökhan M Mutlu; Yochai Adir; Mohammed Jameel; Alexander T Akhmedov; Lynn C Welch; Vidas Dumasius; Fan Jing Meng; Joseph Zabner; Craig Koenig; Erin Rachel Lewis; Rajesh Balagani; Geri L Traver; Jacob I Sznajder; Phillip H. Factor
Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport.
Circulation research 2005;96(9):999-1005.
2005: G R Scott Budinger; Jacob I Sznajder
To live or die: a critical decision for the lung.
The Journal of clinical investigation 2005;115(4):828-30.
2005: David Machado-Aranda; Yochai Adir; Jennifer L Young; Arturo Briva; G R Scott Budinger; Anjana V Yeldandi; Jacob I Sznajder; David A Dean
Gene transfer of the Na+,K+-ATPase beta1 subunit using electroporation increases lung liquid clearance.
American journal of respiratory and critical care medicine 2005;171(3):204-11.
2005: Manu Jain; Jacob I Sznajder
Effects of hypoxia on the alveolar epithelium.
Proceedings of the American Thoracic Society 2005;2(3):202-5.
2005: Gökhan M Mutlu; Jacob I Sznajder
Pseudohypoxemia: interpretation of discrepancies between SaO(2) and SpO(2).
Tüberküloz ve toraks 2005;53(2):185-9.
2005: Manu Jain; Jacob I Sznajder
Low tidal volume needs to be used in patients with acute respiratory distress syndrome.
Critical care medicine 2005;33(1):239-40.
2004: Zaher S Azzam; Yochai Adir; Astrid Crespo; Alejandro P Comellas; Emilia Lecuona; Laura A Dada; Norberto Krivoy; David H Rutschman; Jacob I Sznajder; Karen M Ridge
Norepinephrine increases alveolar fluid reabsorption and Na,K-ATPase activity.
American journal of respiratory and critical care medicine 2004;170(7):730-6.
2004: Gökhan M Mutlu; Jacob I Sznajder
beta(2)-Agonists for treatment of pulmonary edema: ready for clinical studies?
Critical care medicine 2004;32(7):1607-8.
2004: Yochai Adir; Zaher S Azzam; Emilia Lecuona; Sergio Leal; Liuska Pesce; Vidas Dumasius; Alejandro M Bertorello; Phillip H. Factor; James B Young; Karen M Ridge; Jacob I Sznajder
Augmentation of endogenous dopamine production increases lung liquid clearance.
American journal of respiratory and critical care medicine 2004;169(6):757-63.
2004: Daniel E Sloniewsky; Karen M Ridge; Yochai Adir; Francine P Fries; Arturo Briva; Jacob I Sznajder; Peter H S Sporn
Leukotriene D4 activates alveolar epithelial Na,K-ATPase and increases alveolar fluid clearance.
American journal of respiratory and critical care medicine 2004;169(3):407-12.
2003: Yochai Adir; Phillip H. Factor; Vidas Dumasius; Karen M Ridge; Jacob I Sznajder
Na,K-ATPase gene transfer increases liquid clearance during ventilation-induced lung injury.
American journal of respiratory and critical care medicine 2003;168(12):1445-8.
2003: Liuska Pesce; Alejandro P Comellas; Jacob I Sznajder
Beta-adrenergic agonists regulate Na-K-ATPase via p70S6k.
American journal of physiology. Lung cellular and molecular physiology 2003;285(4):L802-7.
2003: Emilia Lecuona; Karen M Ridge; Liuska Pesce; Daniel Batlle; Jacob I Sznajder
The GTP-binding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells.
Molecular biology of the cell 2003;14(9):3888-97.
2003: Daya Upadhyay; Emilia Lecuona; Alejandro P Comellas; David W Kamp; Jacob I Sznajder
Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway.
FEBS letters 2003;545(2-3):173-6.
2003: Dean E Schraufnagel; Narasimhan P Agaram; Aamir Faruqui; Sajal Jain; Leena Jain; Karen M Ridge; Jacob I Sznajder
Pulmonary lymphatics and edema accumulation after brief lung injury.
American journal of physiology. Lung cellular and molecular physiology 2003;284(5):L891-7.
2003: Alejandro P Comellas; Liuska Pesce; Zaher S Azzam; Fernando Saldías; Jacob I Sznajder
Scorpion venom decreases lung liquid clearance in rats.
American journal of respiratory and critical care medicine 2003;167(8):1064-7.
2003: Laura A Dada; Jacob I Sznajder
Mechanisms of pulmonary edema clearance during acute hypoxemic respiratory failure: role of the Na,K-ATPase.
Critical care medicine 2003;31(4 Suppl):S248-52.
2003: Laura A Dada; Navdeep S Chandel; Karen M Ridge; Carlos Pedemonte; Alejandro M Bertorello; Jacob I Sznajder
Hypoxia-induced endocytosis of Na,K-ATPase in alveolar epithelial cells is mediated by mitochondrial reactive oxygen species and PKC-zeta.
The Journal of clinical investigation 2003;111(7):1057-64.
2003: Karen M Ridge; WG Olivera; Fernando J Saldias; Zaher S Azzam; S Horowitz; David H Rutschman; Vidas Dumasius; Phillip H. Factor; Jacob I Sznajder
Alveolar type 1 cells express the alpha2 Na,K-ATPase, which contributes to lung liquid clearance.
Circulation research 2003;92(4):453-60.
2003: Alejandro M Bertorello; Yulia Komarova; Kristen Smith; Ingo B Leibiger; Riad Efendiev; Carlos H Pedemonte; Gary G Borisy; Jacob I Sznajder
Analysis of Na+,K+-ATPase motion and incorporation into the plasma membrane in response to G protein-coupled receptor signals in living cells.
Molecular biology of the cell 2003;14(3):1149-57.
2003: Daya Upadhyay; Eduardo Correa-Meyer; Jacob I Sznajder; David W Kamp
FGF-10 prevents mechanical stretch-induced alveolar epithelial cell DNA damage via MAPK activation.
American journal of physiology. Lung cellular and molecular physiology 2003;284(2):L350-9.
2003: Yochai Adir; Jacob I Sznajder
Regulation of lung edema clearance by dopamine.
The Israel Medical Association journal : IMAJ 2003;5(1):47-50.
2002: Jacob I Sznajder; Phillip H. Factor; D H Ingbar
Invited review: lung edema clearance: role of Na(+)-K(+)-ATPase.
Journal of applied physiology (Bethesda, Md. : 1985) 2002;93(5):1860-6.
2002: Fernando Saldías; Alejandro P Comellas; Liuska Pesce; Emilia Lecuona; Jacob I Sznajder
Dopamine increases lung liquid clearance during mechanical ventilation.
American journal of physiology. Lung cellular and molecular physiology 2002;283(1):L136-43.
2002: G R Scott Budinger; May Tso; David S McClintock; David A Dean; Jacob I Sznajder; Navdeep S Chandel
Hyperoxia-induced apoptosis does not require mitochondrial reactive oxygen species and is regulated by Bcl-2 proteins.
The Journal of biological chemistry 2002;277(18):15654-60.
2002: Carmen Guerrero; Liuska Pesce; Emilia Lecuona; Karen M Ridge; Jacob I Sznajder
Dopamine activates ERKs in alveolar epithelial cells via Ras-PKC-dependent and Grb2/Sos-independent mechanisms.
American journal of physiology. Lung cellular and molecular physiology 2002;282(5):L1099-107.
2002: Eduardo Correa-Meyer; Liuska Pesce; Carmen Guerrero; Jacob I Sznajder
Cyclic stretch activates ERK1/2 via G proteins and EGFR in alveolar epithelial cells.
American journal of physiology. Lung cellular and molecular physiology 2002;282(5):L883-91.
2002: Karen M Ridge; Laura Dada; Emilia Lecuona; Alejandro M Bertorello; Adrian I Katz; Daria Mochly-Rosen; Jacob I Sznajder
Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta.
Molecular biology of the cell 2002;13(4):1381-9.
2002: Phillip H. Factor; Zaher A Azzam; Gökhan M Mutlu; Jacob I Sznajder; Vidas Dumasius
Enhancement of alveolar epithelial beta(2)-adrenergic receptor function via gene transfer.
Chest 2002;121(3 Suppl):45S-46S.
2002: Gökhan M Mutlu; Phillip H. Factor; David E Schwartz; Jacob I Sznajder
Severe status asthmaticus: management with permissive hypercapnia and inhalation anesthesia.
Critical care medicine 2002;30(2):477-80.
2002: Zaher S Azzam; Vidas Dumasius; Fernando J Saldias; Yochai Adir; Jacob I Sznajder; Phillip H. Factor
Na,K-ATPase overexpression improves alveolar fluid clearance in a rat model of elevated left atrial pressure.
Circulation 2002;105(4):497-501.
2001: Vidas Dumasius; Jacob I Sznajder; Zaher S Azzam; John W Boja; Gökhan M Mutlu; M B Maron; Phillip H. Factor
beta(2)-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats.
Circulation research 2001;89(10):907-14.
2001: Fernando Saldías; Zaher S Azzam; Karen M Ridge; A Yeldandi; David H Rutschman; Dean E Schraufnagel; Jacob I Sznajder
Alveolar fluid reabsorption is impaired by increased left atrial pressures in rats.
American journal of physiology. Lung cellular and molecular physiology 2001;281(3):L591-7.
2001: Carmen Guerrero; Emilia Lecuona; Liuska Pesce; Karen M Ridge; Jacob I Sznajder
Dopamine regulates Na-K-ATPase in alveolar epithelial cells via MAPK-ERK-dependent mechanisms.
American journal of physiology. Lung cellular and molecular physiology 2001;281(1):L79-85.
2001: U Thome; L Chen; Phillip H. Factor; Vidas Dumasius; B Freeman; Jacob I Sznajder; Sadis Matalon
Na,K-ATPase gene transfer mitigates an oxidant-induced decrease of active sodium transport in rat fetal ATII cells.
American journal of respiratory cell and molecular biology 2001;24(3):245-52.
2001: Zaher S Azzam; Fernando J Saldias; Alejandro P Comellas; Karen M Ridge; David H Rutschman; Jacob I Sznajder
Catecholamines increase lung edema clearance in rats with increased left atrial pressure.
Journal of applied physiology (Bethesda, Md. : 1985) 2001;90(3):1088-94.
2000: Liuska Pesce; Carmen Guerrero; Alejandro P Comellas; Karen M Ridge; Jacob I Sznajder
beta-agonists regulate Na,K-ATPase via novel MAPK/ERK and rapamycin-sensitive pathways.
FEBS letters 2000;486(3):310-4.
2000: Phillip H. Factor; Vidas Dumasius; Fernando J Saldias; L A Brown; Jacob I Sznajder
Adenovirus-mediated transfer of an Na+/K+-ATPase beta1 subunit gene improves alveolar fluid clearance and survival in hyperoxic rats.
Human gene therapy 2000;11(16):2231-42.
2000: Phillip H. Factor; Karen M Ridge; J Alverdy; Jacob I Sznajder
Continuous enteral nutrition attenuates pulmonary edema in rats exposed to 100% oxygen.
Journal of applied physiology (Bethesda, Md. : 1985) 2000;89(5):1759-65.
2000: Emilia Lecuona; A Garcia; Jacob I Sznajder
A novel role for protein phosphatase 2A in the dopaminergic regulation of Na,K-ATPase.
FEBS letters 2000;481(3):217-20.
2000: Fernando Saldías; Emilia Lecuona; Alejandro P Comellas; Karen M Ridge; David H Rutschman; Jacob I Sznajder
beta-adrenergic stimulation restores rat lung ability to clear edema in ventilator-associated lung injury.
American journal of respiratory and critical care medicine 2000;162(1):282-7.
2000: J E Dematte; Jacob I Sznajder
Mechanisms of pulmonary edema clearance: from basic research to clinical implication.
Intensive care medicine 2000;26(4):477-80.
2000: Zaher S Azzam; Jacob I Sznajder
The cellular mechanisms contributing to lung edema clearance.
The Israel Medical Association journal : IMAJ 2000;2(3):235-9.
2000: WG Olivera; D E Ciccolella; N Barquin; Karen M Ridge; David H Rutschman; D B Yeates; Jacob I Sznajder
Aldosterone regulates Na,K-ATPase and increases lung edema clearance in rats.
American journal of respiratory and critical care medicine 2000;161(2 Pt 1):567-73.
1999: Michele Barnard; Karen M Ridge; Fernando J Saldias; E Friedman; M Gare; Carmen Guerrero; Emilia Lecuona; Alejandro M Bertorello; Adrian I Katz; Jacob I Sznajder
Stimulation of the dopamine 1 receptor increases lung edema clearance.
American journal of respiratory and critical care medicine 1999;160(3):982-6.
1999: C M Waters; Karen M Ridge; G Sunio; K Venetsanou; Jacob I Sznajder
Mechanical stretching of alveolar epithelial cells increases Na(+)-K(+)-ATPase activity.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;87(2):715-21.
1999: Carmen Guerrero; A Ghosh; Emilia Lecuona; Karen M Ridge; E Santos; Jacob I Sznajder
Dopamine regulates NA,K-adenosine triphosphatase in alveolar epithelial cells via the mitogen-activated protein kinase/extracellular-signal-regulated kinase pathway.
Chest 1999;116(1 Suppl):88S-89S.
1999: Emilia Lecuona; Fernando Saldías; Alejandro P Comellas; Karen M Ridge; Carmen Guerrero; Jacob I Sznajder
Ventilator-associated lung injury decreases lung ability to clear edema and downregulates alveolar epithelial cell Na,K-adenosine triphosphatase function.
Chest 1999;116(1 Suppl):29S-30S.
1999: Phillip H. Factor; Vidas Dumasius; Fernando J Saldias; Jacob I Sznajder
Adenoviral-mediated overexpression of the NA,K-ATPase beta1 subunit gene increases lung edema clearance and improves survival during acute hyperoxic lung injury in rats.
Chest 1999;116(1 Suppl):24S-25S.
1999: Fernando Saldías; Alejandro P Comellas; Karen M Ridge; Emilia Lecuona; Jacob I Sznajder
Isoproterenol improves ability of lung to clear edema in rats exposed to hyperoxia.
Journal of applied physiology (Bethesda, Md. : 1985) 1999;87(1):30-5.
1999: Fernando Saldías; Emilia Lecuona; Alejandro P Comellas; Karen M Ridge; Jacob I Sznajder
Dopamine restores lung ability to clear edema in rats exposed to hyperoxia.
American journal of respiratory and critical care medicine 1999;159(2):626-33.
1999: Emilia Lecuona; Fernando Saldías; Alejandro P Comellas; Karen M Ridge; Carmen Guerrero; Jacob I Sznajder
Ventilator-associated lung injury decreases lung ability to clear edema in rats.
American journal of respiratory and critical care medicine 1999;159(2):603-9.
1999: Alejandro M Bertorello; Karen M Ridge; Alexander V Chibalin; Adrian I Katz; Jacob I Sznajder
Isoproterenol increases Na+-K+-ATPase activity by membrane insertion of alpha-subunits in lung alveolar cells.
The American journal of physiology 1999;276(1 Pt 1):L20-7.
1998: Phillip H. Factor; Fernando J Saldias; Karen M Ridge; Vidas Dumasius; Joseph Zabner; H Ari Jaffe; G Blanco; Michele Barnard; RW Mercer; R Perrin; Jacob I Sznajder
Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene.
The Journal of clinical investigation 1998;102(7):1421-30.
1998: Fernando Saldías; Alejandro P Comellas; C Guerrero; Karen M Ridge; David H Rutschman; Jacob I Sznajder
Time course of active and passive liquid and solute movement in the isolated perfused rat lung model.
Journal of applied physiology (Bethesda, Md. : 1985) 1998;85(4):1572-7.
1998: Jacob I Sznajder; A Nahum; D E Hansen; G R Long; L D Wood
Volume recruitment and oxygenation in pulmonary edema: a comparison between HFOV and CMV.
Journal of critical care 1998;13(3):126-35.
1998: Jacob I Sznajder; Karen M Ridge; D B Yeates; J Ilekis; WG Olivera
Epidermal growth factor increases lung liquid clearance in rat lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1998;85(3):1004-10.
1998: Phillip H. Factor; C Senne; Vidas Dumasius; Karen M Ridge; H Ari Jaffe; Bruce D Uhal; Z Gao; Jacob I Sznajder
Overexpression of the Na+,K+-ATPase alpha1 subunit increases Na+,K+-ATPase function in A549 cells.
American journal of respiratory cell and molecular biology 1998;18(6):741-9.
1998: Fernando Saldías; Emilia Lecuona; E Friedman; Michele Barnard; Karen M Ridge; Jacob I Sznajder
Modulation of lung liquid clearance by isoproterenol in rat lungs.
The American journal of physiology 1998;274(5 Pt 1):L694-701.
1997: Karen M Ridge; WG Olivera; David H Rutschman; RW Mercer; Bruce D Uhal; S Horowitz; F Hughes; Phillip H. Factor; Michele Barnard; Jacob I Sznajder
Alpha-2 Na,K-ATPase contributes to lung liquid clearance.
Annals of the New York Academy of Sciences 1997;834():651-2.
1997: Phillip H. Factor; C Senne; Karen M Ridge; H Ari Jaffe; G Blanco; RW Mercer; Jacob I Sznajder
Effects of adenoviral mediated transfer of Na+,K(+)-ATPase subunit genes to alveolar epithelial cells.
Annals of the New York Academy of Sciences 1997;834():104-6.
1997: Michele Barnard; WG Olivera; D M Rutschman; Alejandro M Bertorello; Adrian I Katz; Jacob I Sznajder
Dopamine stimulates sodium transport and liquid clearance in rat lung epithelium.
American journal of respiratory and critical care medicine 1997;156(3 Pt 1):709-14.
1997: Fernando Saldías; Jacob I Sznajder
[Lung volume reduction surgery in patients with emphysema].
Archivos de bronconeumología 1997;33(6):263-7.
1997: Phillip H. Factor; C Senne; Karen M Ridge; H Ari Jaffe; Jacob I Sznajder
Differential effects of adenoviral-mediated transfer of Na+/K(+)-ATPase subunit genes in lung epithelial cells.
Chest 1997;111(6 Suppl):110S-111S.
1997: Jacob I Sznajder; WG Olivera
[New prospects in the clearance of pulmonary edema].
Archivos de bronconeumología 1997;33(5):207-9.
1996: A Pardo; M Selman; Karen M Ridge; R Barrios; Jacob I Sznajder
Increased expression of gelatinases and collagenase in rat lungs exposed to 100% oxygen.
American journal of respiratory and critical care medicine 1996;154(4 Pt 1):1067-75.
1996: B González-Flecha; Pablo Evelson; Karen M Ridge; Jacob I Sznajder
Hydrogen peroxide increases Na+/K(+)-ATPase function in alveolar type II cells.
Biochimica et biophysica acta 1996;1290(1):46-52.
1996: Z Leah Harris; Karen M Ridge; B Gonzalez-Flecha; L Gottlieb; A Zucker; Jacob I Sznajder
Hyperbaric oxygenation upregulates rat lung Na,K-ATPase.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1996;9(3):472-7.
1995: WG Olivera; Karen M Ridge; Jacob I Sznajder
Lung liquid clearance and Na,K-ATPase during acute hyperoxia and recovery in rats.
American journal of respiratory and critical care medicine 1995;152(4 Pt 1):1229-34.
1995: Jacob I Sznajder; WG Olivera; Karen M Ridge; David H Rutschman
Mechanisms of lung liquid clearance during hyperoxia in isolated rat lungs.
American journal of respiratory and critical care medicine 1995;151(5):1519-25.
1994: K D Hainis; Jacob I Sznajder; Dean E Schraufnagel
Lung lymphatics cast from the airspace.
The American journal of physiology 1994;267(2 Pt 1):L199-205.
1994: Edward Naureckas; Phillip H. Factor; O Benjaminov; E Hoffer; V Sriram; Jacob I Sznajder
Pentoxifylline does not protect against hyperoxic lung injury in rats.
The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology 1994;7(8):1397-402.
1994: Dean E Schraufnagel; J L Basterra; K Hainis; Jacob I Sznajder
Lung lymphatics increase after hyperoxic injury. An ultrastructural study of casts.
The American journal of pathology 1994;144(6):1393-402.
1994: WG Olivera; Karen M Ridge; L D Wood; Jacob I Sznajder
Active sodium transport and alveolar epithelial Na-K-ATPase increase during subacute hyperoxia in rats.
The American journal of physiology 1994;266(5 Pt 1):L577-84.
1994: Jacob I Sznajder; Karen M Ridge; Z Leah Harris; WG Olivera; C Curiel; David H Rutschman
Alveolar type II cell Na,K-ATPase is upregulated during mechanical ventilation-induced pulmonary edema.
Chest 1994;105(3 Suppl):116S-117S.
1993: David H Rutschman; WG Olivera; Jacob I Sznajder
Active transport and passive liquid movement in isolated perfused rat lungs.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(4):1574-80.
1993: WG Olivera; Karen M Ridge; L D Wood; Jacob I Sznajder
ANF decreases active sodium transport and increases alveolar epithelial permeability in rats.
Journal of applied physiology (Bethesda, Md. : 1985) 1993;75(4):1581-6.
1992: A R Zucker; B A Holm; G P Crawford; Karen M Ridge; L D Wood; Jacob I Sznajder
PEEP is necessary for exogenous surfactant to reduce pulmonary edema in canine aspiration pneumonitis.
Journal of applied physiology (Bethesda, Md. : 1985) 1992;73(2):679-86.
1991: A Nahum; William H Chamberlin; Jacob I Sznajder
Differential activation of mixed venous and arterial neutrophils in patients with sepsis syndrome and acute lung injury.
The American review of respiratory disease 1991;143(5 Pt 1):1083-7.
1990: J Yanos; K Presberg; G Crawford; J Meller; L D Wood; Jacob I Sznajder
The effect of hypopnea on low-pressure pulmonary edema.
The American review of respiratory disease 1990;142(2):316-20.
1990: T C Corbridge; L D Wood; G P Crawford; M J Chudoba; J Yanos; Jacob I Sznajder
Adverse effects of large tidal volume and low PEEP in canine acid aspiration.
The American review of respiratory disease 1990;142(2):311-5.
1990: A Nahum; M Hegarty; H Chen; William H Chamberlin; Jacob I Sznajder
Effect of sodium azide on hydrogen peroxide production by zymosan-activated human neutrophils.
Inflammation 1990;14(3):285-96.
1990: K W Presberg; Jacob I Sznajder; J Melendres; T Lewis; Cyril Abrahams; L D Wood
Distribution of pulmonary vascular resistance during lactic acid infusion in dogs.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;68(4):1328-36.
1990: A Nahum; L D Wood; G Crawford; R Ripper; L Segil; Jacob I Sznajder
Pathogenesis of pulmonary edema associated with intracisternal endotoxin in dogs.
Journal of applied physiology (Bethesda, Md. : 1985) 1990;68(4):1688-95.
1989: Jacob I Sznajder; A Nahum; G Crawford; E R Pollak; Paul T Schumacker; L D Wood
Alveolar pressure inhomogeneity and gas exchange during constant-flow ventilation in dogs.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;67(4):1489-94.
1989: Jacob I Sznajder; A Fraiman; Jesse B Hall; William M. Sanders; G Schmidt; G Crawford; A Nahum; Phillip H. Factor; L D Wood
Increased hydrogen peroxide in the expired breath of patients with acute hypoxemic respiratory failure.
Chest 1989;96(3):606-12.
1989: Jacob I Sznajder; C J Becker; G P Crawford; L D Wood
Combination of constant-flow and continuous positive-pressure ventilation in canine pulmonary edema.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;67(2):817-23.
1989: Paul T Schumacker; R W Samsel; Jacob I Sznajder; L D Wood; Julian Solway
Gas density dependence of regional VA/V and VA/Q inequality during constant-flow ventilation.
Journal of applied physiology (Bethesda, Md. : 1985) 1989;66(4):1722-9.
1989: A Nahum; L D Wood; Jacob I Sznajder
Measurement of hydrogen peroxide in plasma and blood.
Free radical biology & medicine 1989;6(5):479-84.
1988: Paul T Schumacker; Julian Solway; L D Wood; Jacob I Sznajder
Lobar contribution to VA/Q inequality during constant-flow ventilation.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;65(5):2132-7.
1988: A Nahum; Jacob I Sznajder; Julian Solway; L D Wood; Paul T Schumacker
Pressure, flow, and density relationships in airway models during constant-flow ventilation.
Journal of applied physiology (Bethesda, Md. : 1985) 1988;64(5):2066-73.
1987: Jacob I Sznajder; E Evander; E R Pollak; C Becker; A G Little
Pericardial effusion causes interstitial pulmonary edema in dogs.
Circulation 1987;76(4):843-9.
1987: Paul T Schumacker; Jacob I Sznajder; A Nahum; L D Wood
Ventilation-perfusion inequality during constant-flow ventilation.
Journal of applied physiology (Bethesda, Md. : 1985) 1987;62(3):1255-63.
1986: Jacob I Sznajder; A R Zucker; L D Wood; G R Long
The effects of plasmapheresis and hemofiltration on canine acid aspiration pulmonary edema.
The American review of respiratory disease 1986;134(2):222-8.