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Jack Szostak

Research Profile

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Chemicals & Drugs

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Directed Molecular Evolution

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Saccharomyces cerevisiae

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TOP 3
Aaron E Engelhart; Matthew W Powner; Jack W Szostak
Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity.
Shenglong Zhang; Na Zhang; J Craig Blain; Jack W Szostak
Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension.
Itay Budin; Anik Debnath; Jack W Szostak
Concentration-driven growth of model protocell membranes.

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All Publications

2013: Aaron E Engelhart; Matthew W Powner; Jack W Szostak
Functional RNAs exhibit tolerance for non-heritable 2'-5' versus 3'-5' backbone heterogeneity.
Nature chemistry 2013;5(5):390-4.
2013: Shenglong Zhang; Na Zhang; J Craig Blain; Jack W Szostak
Synthesis of N3'-P5'-linked phosphoramidate DNA by nonenzymatic template-directed primer extension.
Journal of the American Chemical Society 2013;135(2):924-32.
2012: Itay Budin; Anik Debnath; Jack W Szostak
Concentration-driven growth of model protocell membranes.
Journal of the American Chemical Society 2012;134(51):20812-9.
2012: Yollete V Guillen Schlippe; Matthew C T Hartman; Kristopher Josephson; Jack W Szostak
In vitro selection of highly modified cyclic peptides that act as tight binding inhibitors.
Journal of the American Chemical Society 2012;134(25):10469-77.
2012: Ting F Zhu; Na Zhang; Katarzyna Adamala; Jack W Szostak
Photochemically driven redox chemistry induces protocell membrane pearling and division.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(25):9828-32.
2012: Na Zhang; Shenglong Zhang; Jack W Szostak
Activated ribonucleotides undergo a sugar pucker switch upon binding to a single-stranded RNA template.
Journal of the American Chemical Society 2012;134(8):3691-4.
2011: Jack W Szostak
An optimal degree of physical and chemical heterogeneity for the origin of life?
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2011;366(1580):2894-901.
2011: Simon G Trevino; Na Zhang; Mark P Elenko; Andrej Lupták; Jack W Szostak
Evolution of functional nucleic acids in the presence of nonheritable backbone heterogeneity.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(33):13492-7.
2011: Florian P Seebeck; Alonso Ricardo; Jack W Szostak
Artificial lantipeptides from in vitro translations.
Chemical communications (Cambridge, England) 2011;47(21):6141-3.
2011: Itay Budin; Jack W Szostak
Physical effects underlying the transition from primitive to modern cell membranes.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(13):5249-54.
2011: Alexander O Subtelny; Matthew C T Hartman; Jack W Szostak
Optimal codon choice can improve the efficiency and fidelity of N-methyl amino acid incorporation into peptides by in-vitro translation.
Angewandte Chemie (International ed. in English) 2011;50(14):3164-7.
2010: Matthew W Powner; John D Sutherland; Jack W Szostak
Chemoselective multicomponent one-pot assembly of purine precursors in water.
Journal of the American Chemical Society 2010;132(46):16677-88.
2010: Jack W Szostak
DNA ends: just the beginning (Nobel lecture).
Angewandte Chemie (International ed. in English) 2010;49(41):7386-404.
2010: Jason P Schrum; Ting F Zhu; Jack W Szostak
The origins of cellular life.
Cold Spring Harbor perspectives in biology 2010;2(9):a002212.
2010: Itay Budin; Jack W Szostak
Expanding roles for diverse physical phenomena during the origin of life.
Annual review of biophysics 2010;39():245-63.
2009: Jason P Schrum; Alonso Ricardo; Mathangi Krishnamurthy; J Craig Blain; Jack W Szostak
Efficient and rapid template-directed nucleic acid copying using 2'-amino-2',3'-dideoxyribonucleoside-5'-phosphorimidazolide monomers.
Journal of the American Chemical Society 2009;131(40):14560-70.
2009: Itay Budin; Raphael J Bruckner; Jack W Szostak
Formation of protocell-like vesicles in a thermal diffusion column.
Journal of the American Chemical Society 2009;131(28):9628-9.
2009: Alexander Litovchick; Jack W Szostak
Retraction for Litovchick and Szostak. "Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display".
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):7263.
2009: Ting F Zhu; Jack W Szostak
Coupled growth and division of model protocell membranes.
Journal of the American Chemical Society 2009;131(15):5705-13.
2009: Jesse J Chen; Xin Cai; Jack W Szostak
N2'-->p3' phosphoramidate glycerol nucleic acid as a potential alternative genetic system.
Journal of the American Chemical Society 2009;131(6):2119-21.
2009: Ting F Zhu; Jack W Szostak
Preparation of large monodisperse vesicles.
PloS one 2009;4(4):e5009.
2009: Jesse J Chen; Ching-Hsuan Tsai; Xin Cai; Allen T Horhota; Larry W McLaughlin; Jack W Szostak
Enzymatic primer-extension with glycerol-nucleoside triphosphates on DNA templates.
PloS one 2009;4(3):e4949.
2008: Alexander Litovchick; Jack W Szostak
Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(40):15293-8.
2008: Sheref S Mansy; Jack W Szostak
Thermostability of model protocell membranes.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(36):13351-5.
2008: Sheref S Mansy; Jason Schrum; Mathangi Krishnamurthy; Sylvia Tobé; Douglas Treco; Jack W Szostak
Template-directed synthesis of a genetic polymer in a model protocell.
Nature 2008;454(7200):122-5.
2008: Alexander O Subtelny; Matthew C T Hartman; Jack W Szostak
Ribosomal synthesis of N-methyl peptides.
Journal of the American Chemical Society 2008;130(19):6131-6.
2008: Pierre-Alain Monnard; Jack W Szostak
Metal-ion catalyzed polymerization in the eutectic phase in water-ice: a possible approach to template-directed RNA polymerization.
Journal of inorganic biochemistry 2008;102(5-6):1104-11.
2007: Burckhard Seelig; Jack W Szostak
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold.
Nature 2007;448(7155):828-31.
2007: Sheref S Mansy; Jinglei Zhang; Rainer Kümmerle; Mikael Nilsson; James J Chou; Jack W Szostak; John C Chaput
Structure and evolutionary analysis of a non-biological ATP-binding protein.
Journal of molecular biology 2007;371(2):501-13.
2007: Robert M Hazen; Patrick L Griffin; James M Carothers; Jack W Szostak
Functional information and the emergence of biocomplexity.
Proceedings of the National Academy of Sciences of the United States of America 2007;104 Suppl 1():8574-81.
2007: Mui Sam; Kathryn Pierce; Jack W Szostak; Larry W McLaughlin
2',3'-Dideoxy-3'-thionucleoside triphosphates: syntheses and polymerase substrate activities.
Organic letters 2007;9(6):1161-3.
2007: Martin M Hanczyc; Sheref S Mansy; Jack W Szostak
Mineral surface directed membrane assembly.
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life 2007;37(1):67-82.
2007: Matthew C T Hartman; Kristopher Josephson; Chi-Wang Lin; Jack W Szostak
An expanded set of amino acid analogs for the ribosomal translation of unnatural peptides.
PloS one 2007;2(10):e972.
2007: Matthew D Smith; Matthew A Rosenow; Meitian Wang; James P Allen; Jack W Szostak; John C Chaput
Structural insights into the evolution of a non-biological protein: importance of surface residues in protein fold optimization.
PloS one 2007;2(5):e467.
2006: Allen Horhota; Jack W Szostak; Larry W McLaughlin
Glycerol nucleoside triphosphates: synthesis and polymerase substrate activities.
Organic letters 2006;8(23):5345-7.
2006: Kourosh Salehi-Ashtiani; Andrej Lupták; Alexander Litovchick; Jack W Szostak
A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene.
Science (New York, N.Y.) 2006;313(5794):1788-92.
2006: James M Carothers; Stephanie C Oestreich; Jack W Szostak
Aptamers selected for higher-affinity binding are not more specific for the target ligand.
Journal of the American Chemical Society 2006;128(24):7929-37.
2006: James M Carothers; Jonathan H Davis; James J Chou; Jack W Szostak
Solution structure of an informationally complex high-affinity RNA aptamer to GTP.
RNA (New York, N.Y.) 2006;12(4):567-79.
2006: Matthew C T Hartman; Kristopher Josephson; Jack W Szostak
Enzymatic aminoacylation of tRNA with unnatural amino acids.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(12):4356-61.
2006: Glen S Cho; Jack W Szostak
Directed evolution of ATP binding proteins from a zinc finger domain by using mRNA display.
Chemistry & biology 2006;13(2):139-47.
2005: Shelly M Fujikawa; Irene Ann Chen; Jack W Szostak
Shrink-wrap vesicles.
Langmuir : the ACS journal of surfaces and colloids 2005;21(26):12124-9.
2005: Irene Ann Chen; Kourosh Salehi-Ashtiani; Jack W Szostak
RNA catalysis in model protocell vesicles.
Journal of the American Chemical Society 2005;127(38):13213-9.
2005: Kristopher Josephson; Matthew C T Hartman; Jack W Szostak
Ribosomal synthesis of unnatural peptides.
Journal of the American Chemical Society 2005;127(33):11727-35.
2005: Allen Horhota; Keyong Zou; Justin K Ichida; Biao Yu; Larry W McLaughlin; Jack W Szostak; John C Chaput
Kinetic analysis of an efficient DNA-dependent TNA polymerase.
Journal of the American Chemical Society 2005;127(20):7427-34.
2005: M G Sacerdote; Jack W Szostak
Semipermeable lipid bilayers exhibit diastereoselectivity favoring ribose.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(17):6004-8.
2005: Keyong Zou; Allen Horhota; Biao Yu; Jack W Szostak; Larry W McLaughlin
Synthesis of alpha-L-threofuranosyl nucleoside triphosphates (tNTPs).
Organic letters 2005;7(8):1485-7.
2005: Justin K Ichida; Keyong Zou; Allen Horhota; Biao Yu; Larry W McLaughlin; Jack W Szostak
An in vitro selection system for TNA.
Journal of the American Chemical Society 2005;127(9):2802-3.
2005: Kelly A Plummer; James M Carothers; Masahiro Yoshimura; Jack W Szostak; Gregory L Verdine
In vitro selection of RNA aptamers against a composite small molecule-protein surface.
Nucleic acids research 2005;33(17):5602-10.
2005: Justin K Ichida; Allen Horhota; Keyong Zou; Larry W McLaughlin; Jack W Szostak
High fidelity TNA synthesis by Therminator polymerase.
Nucleic acids research 2005;33(16):5219-25.
2004: Martin M Hanczyc; Jack W Szostak
Replicating vesicles as models of primitive cell growth and division.
Current opinion in chemical biology 2004;8(6):660-4.
2004: Irene Ann Chen; Richard W Roberts; Jack W Szostak
The emergence of competition between model protocells.
Science (New York, N.Y.) 2004;305(5689):1474-6.
2004: Irene Ann Chen; Jack W Szostak
A kinetic study of the growth of fatty acid vesicles.
Biophysical journal 2004;87(2):988-98.
2004: Peter L Sazani; Rosa Larralde; Jack W Szostak
A small aptamer with strong and specific recognition of the triphosphate of ATP.
Journal of the American Chemical Society 2004;126(27):8370-1.
2004: John C Chaput; Jack W Szostak
Evolutionary optimization of a nonbiological ATP binding protein for improved folding stability.
Chemistry & biology 2004;11(6):865-74.
2004: Irene Ann Chen; Jack W Szostak
Membrane growth can generate a transmembrane pH gradient in fatty acid vesicles.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(21):7965-70.
2004: James M Carothers; Stephanie C Oestreich; Jonathan H Davis; Jack W Szostak
Informational complexity and functional activity of RNA structures.
Journal of the American Chemical Society 2004;126(16):5130-7.
2003: Martin M Hanczyc; Shelly M Fujikawa; Jack W Szostak
Experimental models of primitive cellular compartments: encapsulation, growth, and division.
Science (New York, N.Y.) 2003;302(5645):618-22.
2003: John C Chaput; Jack W Szostak
TNA synthesis by DNA polymerases.
Journal of the American Chemical Society 2003;125(31):9274-5.
2003: Narendra K Vaish; Rosa Larralde; Andrew Fraley; Jack W Szostak; Larry W McLaughlin
A novel, modification-dependent ATP-binding aptamer selected from an RNA library incorporating a cationic functionality.
Biochemistry 2003;42(29):8842-51.
2003: Jack W Szostak
Functional information: Molecular messages.
Nature 2003;423(6941):689.
2003: John C Chaput; Justin K Ichida; Jack W Szostak
DNA polymerase-mediated DNA synthesis on a TNA template.
Journal of the American Chemical Society 2003;125(4):856-7.
2002: Jonathan H Davis; Jack W Szostak
Isolation of high-affinity GTP aptamers from partially structured RNA libraries.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11616-21.
2002: Rick Baggio; Petra Burgstaller; Stephen P Hale; Andrew R Putney; Meghan Lane; Dasa Lipovsek; Martin C Wright; Richard W Roberts; Rihe Liu; Jack W Szostak; Richard Wagner
Identification of epitope-like consensus motifs using mRNA display.
Journal of molecular recognition : JMR 2002;15(3):126-34.
2001: AD Keefe; DS Wilson; B Seelig; Jack W Szostak
One-step purification of recombinant proteins using a nanomolar-affinity streptavidin-binding peptide, the SBP-Tag.
Protein expression and purification 2001;23(3):440-6.
2001: Kourosh Salehi-Ashtiani; Jack W Szostak
In vitro evolution suggests multiple origins for the hammerhead ribozyme.
Nature 2001;414(6859):82-4.
2001: AD Keefe; Jack W Szostak
Functional proteins from a random-sequence library.
Nature 2001;410(6829):715-8.
2001: DS Wilson; AD Keefe; Jack W Szostak
The use of mRNA display to select high-affinity protein-binding peptides.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(7):3750-5.
2001: Jack W Szostak; David P Bartel; P L Luisi
Synthesizing life.
Nature 2001;409(6818):387-90.
2000: Narendra K Vaish; Andrew Fraley; Jack W Szostak; Larry W McLaughlin
Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids.
Nucleic acids research 2000;28(17):3316-22.
2000: G Cho; AD Keefe; Rihe Liu; DS Wilson; Jack W Szostak
Constructing high complexity synthetic libraries of long ORFs using in vitro selection.
Journal of molecular biology 2000;297(2):309-19.
2000: Rihe Liu; Jeffrey E Barrick; Jack W Szostak; Richard W Roberts
Optimized synthesis of RNA-protein fusions for in vitro protein selection.
Methods in enzymology 2000;318():268-93.
1999: DS Wilson; Jack W Szostak
In vitro selection of functional nucleic acids.
Annual review of biochemistry 1999;68():611-47.
1998: H Suga; J A Cowan; Jack W Szostak
Unusual metal ion catalysis in an acyl-transferase ribozyme.
Biochemistry 1998;37(28):10118-25.
1998: H Suga; P A Lohse; Jack W Szostak
Structural and kinetic characterization of an acyl transferase ribozyme.
Journal of the American Chemical Society 1998;120(6):1151-6.
1997: Richard W Roberts; Jack W Szostak
RNA-peptide fusions for the in vitro selection of peptides and proteins.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(23):12297-302.
1997: A J Hager; Jack W Szostak
Isolation of novel ribozymes that ligate AMP-activated RNA substrates.
Chemistry & biology 1997;4(8):607-17.
1997: Jack W Szostak
In vitro selection and directed evolution.
Harvey lectures 1997;93():95-118.
1996: Zhen Huang; Jack W Szostak
A simple method for 3'-labeling of RNA.
Nucleic acids research 1996;24(21):4360-1.
1996: A J Hager; J D Pollard; Jack W Szostak
Ribozymes: aiming at RNA replication and protein synthesis.
Chemistry & biology 1996;3(9):717-25.
1996: R Rohatgi; D P Bartel; Jack W Szostak
Nonenzymatic, template-directed ligation of oligoribonucleotides is highly regioselective for the formation of 3'-5' phosphodiester bonds.
Journal of the American Chemical Society 1996;118(14):3340-4.
1996: R Rohatgi; D P Bartel; Jack W Szostak
Kinetic and mechanistic analysis of nonenzymatic, template-directed oligoribonucleotide ligation.
Journal of the American Chemical Society 1996;118(14):3332-9.
1996: Jon R Lorsch; Jack W Szostak
Chance and necessity in the selection of nucleic acid catalysts.
Accounts of chemical research 1996;29(2):103-10.
1995: Jon R Lorsch; Jack W Szostak
Kinetic and thermodynamic characterization of the reaction catalyzed by a polynucleotide kinase ribozyme.
Biochemistry 1995;34(46):15315-27.
1995: Jon R Lorsch; D P Bartel; Jack W Szostak
Reverse transcriptase reads through a 2'-5'linkage and a 2'-thiophosphate in a template.
Nucleic acids research 1995;23(15):2811-4.
1995: K B Chapman; Jack W Szostak
Isolation of a ribozyme with 5'-5' ligase activity.
Chemistry & biology 1995;2(5):325-33.
1995: C Wilson; Jack W Szostak
In vitro evolution of a self-alkylating ribozyme.
Nature 1995;374(6525):777-82.
1995: S K Whoriskey; N Usman; Jack W Szostak
Total chemical synthesis of a ribozyme derived from a group I intron.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(7):2465-9.
1995: C T Lauhon; Jack W Szostak
RNA aptamers that bind flavin and nicotinamide redox cofactors.
Journal of the American Chemical Society 1995;117(4):1246-57.
1995: D E Huizenga; Jack W Szostak
A DNA aptamer that binds adenosine and ATP.
Biochemistry 1995;34(2):656-65.
1994: M Hanna; Jack W Szostak
Suppression of mutations in the core of the Tetrahymena ribozyme by spermidine, ethanol and by substrate stabilization.
Nucleic acids research 1994;22(24):5326-31.
1994: Jon R Lorsch; Jack W Szostak
In vitro evolution of new ribozymes with polynucleotide kinase activity.
Nature 1994;371(6492):31-6.
1994: C W Lin; M Hanna; Jack W Szostak
Evidence that the guanosine substrate of the Tetrahymena ribozyme is bound in the anti conformation and that N7 contributes to binding.
Biochemistry 1994;33(9):2703-7.
1994: Jon R Lorsch; Jack W Szostak
In vitro selection of RNA aptamers specific for cyanocobalamin.
Biochemistry 1994;33(4):973-82.
1994: Rachel Green; Jack W Szostak
In vitro genetic analysis of the hinge region between helical elements P5-P4-P6 and P7-P3-P8 in the sunY group I self-splicing intron.
Journal of molecular biology 1994;235(1):140-55.
1993: D P Bartel; Jack W Szostak
Isolation of new ribozymes from a large pool of random sequences [see comment].
Science (New York, N.Y.) 1993;261(5127):1411-8.
1993: Jennifer A Doudna; N Usman; Jack W Szostak
Ribozyme-catalyzed primer extension by trinucleotides: a model for the RNA-catalyzed replication of RNA.
Biochemistry 1993;32(8):2111-5.
1992: Rachel Green; Jack W Szostak
Selection of a ribozyme that functions as a superior template in a self-copying reaction.
Science (New York, N.Y.) 1992;258(5090):1910-5.
1992: L O Ross; Douglas Treco; A Nicolas; Jack W Szostak; D Dawson
Meiotic recombination on artificial chromosomes in yeast.
Genetics 1992;131(3):541-50.
1992: E C Park; Jack W Szostak
ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity.
The EMBO journal 1992;11(6):2087-93.
1992: A D Ellington; Jack W Szostak
Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures.
Nature 1992;355(6363):850-2.
1992: E C Park; D Finley; Jack W Szostak
A strategy for the generation of conditional mutations by protein destabilization.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(4):1249-52.
1991: H Sun; D Dawson; Jack W Szostak
Genetic and physical analyses of sister chromatid exchange in yeast meiosis.
Molecular and cellular biology 1991;11(12):6328-36.
1991: D P Bartel; Maria L Zapp; Michael R Green; Jack W Szostak
HIV-1 Rev regulation involves recognition of non-Watson-Crick base pairs in viral RNA.
Cell 1991;67(3):529-36.
1991: Rachel Green; Jack W Szostak; S A Benner; A Rich; N Usman
Synthesis of RNA containing inosine: analysis of the sequence requirements for the 5' splice site of the Tetrahymena group I intron.
Nucleic acids research 1991;19(15):4161-6.
1991: D P Bartel; Jennifer A Doudna; N Usman; Jack W Szostak
Template-directed primer extension catalyzed by the Tetrahymena ribozyme.
Molecular and cellular biology 1991;11(6):3390-4.
1991: Jennifer A Doudna; S Couture; Jack W Szostak
A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis.
Science (New York, N.Y.) 1991;251(5001):1605-8.
1991: H Sun; Douglas Treco; Jack W Szostak
Extensive 3'-overhanging, single-stranded DNA associated with the meiosis-specific double-strand breaks at the ARG4 recombination initiation site.
Cell 1991;64(6):1155-61.
1991: U Pace; Jack W Szostak
Mutations in a semiconserved region of the Tetrahymena intron.
FEBS letters 1991;280(1):171-4.
1991: N P Schultes; Jack W Szostak
A poly(dA.dT) tract is a component of the recombination initiation site at the ARG4 locus in Saccharomyces cerevisiae.
Molecular and cellular biology 1991;11(1):322-8.
1990: N P Schultes; A D Ellington; J M Cherry; Jack W Szostak
Saccharomyces cerevisiae homoserine kinase is homologous to prokaryotic homoserine kinases.
Gene 1990;96(2):177-80.
1990: N P Schultes; Jack W Szostak
Decreasing gradients of gene conversion on both sides of the initiation site for meiotic recombination at the ARG4 locus in yeast.
Genetics 1990;126(4):813-22.
1990: Jennifer A Doudna; Jack W Szostak; Alexander Rich; N Usman
Chemical synthesis of oligoribonucleotides containing 2-aminopurine: substrates for the investigation of ribozyme function.
The Journal of organic chemistry 1990;55(21):5547-9.
1990: F Michel; A D Ellington; S Couture; Jack W Szostak
Phylogenetic and genetic evidence for base-triples in the catalytic domain of group I introns.
Nature 1990;347(6293):578-80.
1990: S Couture; A D Ellington; A S Gerber; J M Cherry; Jennifer A Doudna; Rachel Green; M Hanna; U Pace; J Rajagopal; Jack W Szostak
Mutational analysis of conserved nucleotides in a self-splicing group I intron.
Journal of molecular biology 1990;215(3):345-58.
1990: M Lichten; C Goyon; N P Schultes; Douglas Treco; Jack W Szostak; J E Haber; A Nicolas
Detection of heteroduplex DNA molecules among the products of Saccharomyces cerevisiae meiosis.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(19):7653-7.
1990: Rachel Green; A D Ellington; Jack W Szostak
In vitro genetic analysis of the Tetrahymena self-splicing intron.
Nature 1990;347(6291):406-8.
1990: E C Park; Jack W Szostak
Point mutations in the yeast histone H4 gene prevent silencing of the silent mating type locus HML.
Molecular and cellular biology 1990;10(9):4932-4.
1990: A D Ellington; Jack W Szostak
In vitro selection of RNA molecules that bind specific ligands.
Nature 1990;346(6287):818-22.
1989: Jennifer A Doudna; Jack W Szostak
Miniribozymes, small derivatives of the sunY intron, are catalytically active.
Molecular and cellular biology 1989;9(12):5480-3.
1989: F Michel; M Hanna; Rachel Green; D P Bartel; Jack W Szostak
The guanosine binding site of the Tetrahymena ribozyme.
Nature 1989;342(6248):391-5.
1989: Jennifer A Doudna; Brendan P Cormack; Jack W Szostak
RNA structure, not sequence, determines the 5' splice-site specificity of a group I intron.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(19):7402-6.
1989: Jennifer A Doudna; Jack W Szostak
RNA-catalysed synthesis of complementary-strand RNA.
Nature 1989;339(6225):519-22.
1989: J Rajagopal; Jennifer A Doudna; Jack W Szostak
Stereochemical course of catalysis by the Tetrahymena ribozyme.
Science (New York, N.Y.) 1989;244(4905):692-4.
1989: H Sun; Douglas Treco; N P Schultes; Jack W Szostak
Double-strand breaks at an initiation site for meiotic gene conversion.
Nature 1989;338(6210):87-90.
1989: A Nicolas; Douglas Treco; N P Schultes; Jack W Szostak
An initiation site for meiotic gene conversion in the yeast Saccharomyces cerevisiae.
Nature 1989;338(6210):35-9.
1988: Terry L. Orr-Weaver; A Nicolas; Jack W Szostak
Gene conversion adjacent to regions of double-strand break repair.
Molecular and cellular biology 1988;8(12):5292-8.
1988: A W Murray; T E Claus; Jack W Szostak
Characterization of two telomeric DNA processing reactions in Saccharomyces cerevisiae.
Molecular and cellular biology 1988;8(11):4642-50.
1987: M Whiteway; R Freedman; S Van Arsdell; Jack W Szostak; Jeremy Thorner
The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus.
Molecular and cellular biology 1987;7(10):3713-22.
1987: A E Reynolds; A W Murray; Jack W Szostak
Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae.
Molecular and cellular biology 1987;7(10):3566-73.
1987: Jennifer A Doudna; A S Gerber; J M Cherry; Jack W Szostak
Genetic dissection of an RNA enzyme.
Cold Spring Harbor symposia on quantitative biology 1987;52():173-80.
1986: A W Murray; N P Schultes; Jack W Szostak
Chromosome length controls mitotic chromosome segregation in yeast.
Cell 1986;45(4):529-36.