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Moshe Szyf

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Physiology

Chemicals & Drugs

Anatomy

Phenomena

Methylation

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Publications

TOP 3
Benoit Labonté; Juan Pablo Lopez; Gilles Maussion; Michael J Meaney; Naguib Mechawar; Luis Navarro-Sánchez; Matt Suderman; Moshe Szyf; Volodymyr Yerko; Gustavo Turecki
Genome-wide methylation changes in the brains of suicide completers.
Matthew Suderman; Nada Borghol; Michael T Hallett; Clyde Hertzman; Wendy McArdle; Jane J Pappas; Marcus E Pembrey; Chris Power; Ariane Racine; Moshe Szyf
Epigenomic socioeconomic studies more similar than different.
Ariann Crudo; Michael Hallett; Alice Kostaki; Vasilis G Moisiadis; Sophie Petropoulos; Matthew Suderman; Moshe Szyf; Stephen G Matthews
Glucocorticoid programming of the fetal male hippocampal epigenome.

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All Publications

2013: Benoit Labonté; Juan Pablo Lopez; Gilles Maussion; Michael J Meaney; Naguib Mechawar; Luis Navarro-Sánchez; Matt Suderman; Moshe Szyf; Volodymyr Yerko; Gustavo Turecki
Genome-wide methylation changes in the brains of suicide completers.
The American journal of psychiatry 2013;170(5):511-20.
2013: Matthew Suderman; Nada Borghol; Michael T Hallett; Clyde Hertzman; Wendy McArdle; Jane J Pappas; Marcus E Pembrey; Chris Power; Ariane Racine; Moshe Szyf
Epigenomic socioeconomic studies more similar than different.
Proceedings of the National Academy of Sciences of the United States of America 2013;110(14):E1246.
2013: Ariann Crudo; Michael Hallett; Alice Kostaki; Vasilis G Moisiadis; Sophie Petropoulos; Matthew Suderman; Moshe Szyf; Stephen G Matthews
Glucocorticoid programming of the fetal male hippocampal epigenome.
Endocrinology 2013;154(3):1168-80.
2013: Sebastian Alvarado; Magali Millecamps; Laura S Stone; Mathew Suderman; Maral Tajerian; Moshe Szyf
Peripheral nerve injury is accompanied by chronic transcriptome-wide changes in the mouse prefrontal cortex.
Molecular pain 2013;9():21.
2013: Linda Booij; Mélissa L Lévesque; Richard E Tremblay; Dongsha Wang; Moshe Szyf
Looking beyond the DNA sequence: the relevance of DNA methylation processes for the stress-diathesis model of depression.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 2013;368(1615):20120251.
2013: Maral Tajerian; Pascal Vachon; Moshe Szyf; Sebastian Alvarado; M Catherine Bushnell; Cecilia Crosby; Magali Millecamps; Laura S Stone
Peripheral nerve injury is associated with chronic, reversible changes in global DNA methylation in the mouse prefrontal cortex.
PloS one 2013;8(1):e55259.
2013: Moshe Szyf
How do environments talk to genes?
Nature neuroscience 2013;16(1):2-4.
2013: Laura S Stone; Moshe Szyf
The emerging field of pain epigenetics.
Pain 2013;154(1):1-2.
2013: Moshe Szyf; Johanna Bick
DNA methylation: a mechanism for embedding early life experiences in the genome.
Child development 2013;84(1):49-57.
2012: Nadine Provençal; Angela Ruggiero; Matthew J Suderman; Stephen J Suomi; Allyson J Bennett; Sylvana M Côté; David P Friedman; Claire Guillemin; Michael Hallett; Renaud Massart; Peter J Pierre; Richard E Tremblay; Dongsha Wang; Moshe Szyf
The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012;32(44):15626-42.
2012: Matthew Suderman; Gustavo Turecki; Michael T Hallett; Tony C T Huang; Patrick O McGowan; Michael J Meaney; Aya Sasaki; Moshe Szyf
Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus.
Proceedings of the National Academy of Sciences of the United States of America 2012;109 Suppl 2():17266-72.
2012: Benoit Labonté; Ian Mahar; Gilles Maussion; Michael J Meaney; Naguib Mechawar; Luis Navaro; Matt Suderman; Moshe Szyf; Alexandre Bureau; Volodymyr Yerko; Gustavo Turecki
Genome-wide epigenetic regulation by early-life trauma.
Archives of general psychiatry 2012;69(7):722-31.
2012: Ariann Crudo; Majid Iqbal; Alice Kostaki; Ziv Machnes; Vasilis G Moisiadis; Sophie Petropoulos; Moshe Szyf; Stephen G Matthews
Prenatal synthetic glucocorticoid treatment changes DNA methylation states in male organ systems: multigenerational effects.
Endocrinology 2012;153(7):3269-83.
2012: Benoit Labonte; Michael J Meaney; Naguib Mechawar; Moshe Szyf; Jeffrey Gross; Volodymyr Yerko; Gustavo Turecki
Differential glucocorticoid receptor exon 1(B), 1(C), and 1(H) expression and methylation in suicide completers with a history of childhood abuse.
Biological psychiatry 2012;72(1):41-8.
2012: Allen W Cowley; Myriam Fornage; Andrea Baccarelli; Kathleen Berecek; Gary H Gibbons; David G Harrison; Mingyu Liang; Joseph H Nadeau; Peter W Nathanielsz; Daniel T O'Connor; Jose Ordovas; Weiqun Peng; Marcelo Bento Soares; Moshe Szyf; H Eser Tolunay; Katherine C Wood; Keji Zhao; Zorina S Galis
Report of the National Heart, Lung, and Blood Institute Working Group on epigenetics and hypertension.
Hypertension 2012;59(5):899-905.
2012: Moshe Szyf
Inflammation and age-dependent DNA demethylation.
Epigenomics 2012;4(1):16.
2012: Moshe Szyf
Genes methylated in cancer that are resistant to activation by DNA demethylating agents and histone deacetylase inhibitors.
Epigenomics 2012;4(1):15.
2012: Moshe Szyf
DNA methylation biomarkers for colorectal carcinoma and adenomatous polyps.
Epigenomics 2012;4(1):14-5.
2012: Nada Borghol; Michael Hallett; Clyde Hertzman; Wendy McArdle; Marcus Pembrey; Chris Power; Ariane Racine; Matthew Suderman; Moshe Szyf
Associations with early-life socio-economic position in adult DNA methylation.
International journal of epidemiology 2012;41(1):62-74.
2012: Moshe Szyf
Heterogeneous DNA methylation as an early marker of cancer.
Epigenomics 2012;4(1):13-4.
2012: Oksana Yu Naumova; Moshe Szyf; Mary Dozier; Roman A Koposov; Maria Lee; Elena L Grigorenko
Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents.
Development and psychopathology 2012;24(1):143-55.
2012: Moshe Szyf
Mind-body interrelationship in DNA methylation.
Chemical immunology and allergy 2012;98():85-99.
2012: Dongsha Wang; Chawki Benkelfat; Doretta Caramaschi; Sylvana M Côté; Nadine Provençal; Moshe Szyf; Richard E Tremblay; Gustavo Turecki; Frank Vitaro; Linda Booij
Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression.
PloS one 2012;7(6):e39501.
2012: Ekaterina Yurchenko; Marina Tiemi Shio; Moshe Szyf; Maria Da Silva Martins; Tony C Huang; Megan K Levings; Martin Olivier; Ciriaco Piccirillo
Inflammation-driven reprogramming of CD4+ Foxp3+ regulatory T cells into pathogenic Th1/Th17 T effectors is abrogated by mTOR inhibition in vivo.
PloS one 2012;7(4):e35572.
2011: Barbara Stefanska; Matthew Suderman; Bishnu Bhattacharyya; Michael Hallett; Ze-Guang Han; Jian Huang; Moshe Szyf
Definition of the landscape of promoter DNA hypomethylation in liver cancer.
Cancer research 2011;71(17):5891-903.
2011: Moshe Szyf
DNA methylation, the early-life social environment and behavioral disorders.
Journal of neurodevelopmental disorders 2011;3(3):238-49.
2011: Moshe Szyf
The early life social environment and DNA methylation: DNA methylation mediating the long-term impact of social environments early in life.
Epigenetics : official journal of the DNA Methylation Society 2011;6(8):971-8.
2011: Moshe Szyf
The implications of DNA methylation for toxicology: toward toxicomethylomics, the toxicology of DNA methylation.
Toxicological sciences : an official journal of the Society of Toxicology 2011;120(2):235-55.
2011: M T Ferretti; V Partridge; W C Leon; Fabio Canneva; S Allard; D N Arvanitis; Freya Vercauteren; D Houle; Adriana Ducatenzeiler; William L Klein; C G Glabe; Moshe Szyf; A Claudio Cuello
Transgenic mice as a model of pre-clinical Alzheimer's disease.
Current Alzheimer research 2011;8(1):4-23.
2011: Flora Chik; Moshe Szyf
Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors.
Carcinogenesis 2011;32(2):224-32.
2011: Flora Chik; Moshe Szyf; Shafaat A Rabbani
Role of epigenetics in cancer initiation and progression.
Advances in experimental medicine and biology 2011;720():91-104.
2011: Maral Tajerian; Moshe Szyf; Sebastian Alvarado; Kathleen M Anderson; Thomas Dashwood; Lisbet Haglund; Magali Millecamps; Jean Ouellet; Laura S Stone
DNA methylation of SPARC and chronic low back pain.
Molecular pain 2011;7():65.
2011: Patrick O McGowan; Matthew Suderman; Aya Sasaki; Tony C T Huang; Michael Hallett; Michael J Meaney; Moshe Szyf
Broad epigenetic signature of maternal care in the brain of adult rats.
PloS one 2011;6(2):e14739.
2010: Moshe Szyf
A dynamic methylome; implications of non-CG methylation/demethylation.
Cell cycle (Georgetown, Tex.) 2010;9(19):3846-7.
2010: Moshe Szyf
DNA methylation and demethylation probed by small molecules.
Biochimica et biophysica acta 2010;1799(10-12):750-9.
2010: Patrick O McGowan; Moshe Szyf
Environmental epigenomics: understanding the effects of parental care on the epigenome.
Essays in biochemistry 2010;48(1):275-87.
2010: Richard E Tremblay; Moshe Szyf
Developmental origins of chronic physical aggression and epigenetics.
Epigenomics 2010;2(4):495-9.
2010: Moshe Szyf
Epigenetic therapeutics in autoimmune disease.
Clinical reviews in allergy & immunology 2010;39(1):62-77.
2010: Patrick O McGowan; Moshe Szyf
The epigenetics of social adversity in early life: implications for mental health outcomes.
Neurobiology of disease 2010;39(1):66-72.
2010: Wanda Carolina Leon; Fabio Canneva; Vanessa Partridge; Simon Allard; Maria Teresa Ferretti; Arald DeWilde; Freya Vercauteren; Ramtin Atifeh; Adriana Ducatenzeiler; William L Klein; Moshe Szyf; Leena Alhonen; A Claudio Cuello
A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment.
Journal of Alzheimer's disease : JAD 2010;20(1):113-26.
2009: Antonei B Csoka; Moshe Szyf
Epigenetic side-effects of common pharmaceuticals: a potential new field in medicine and pharmacology.
Medical hypotheses 2009;73(5):770-80.
2009: Moshe Szyf
Implications of a life-long dynamic epigenome.
Epigenomics 2009;1(1):9-12.
2009: Moshe Szyf
The early life environment and the epigenome.
Biochimica et biophysica acta 2009;1790(9):878-85.
2009: Moshe Szyf
Early life, the epigenome and human health.
Acta paediatrica (Oslo, Norway : 1992) 2009;98(7):1082-4.
2009: Patrick O McGowan; Aya Sasaki; Ana C D'Alessio; Sergiy Dymov; Benoit Labonté; Moshe Szyf; Gustavo Turecki; Michael J Meaney
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse.
Nature neuroscience 2009;12(3):342-8.
2009: Carl Ernst; Vesselina Deleva; Xiaoming Deng; Pedro Adolfo Sequeira; Amanda Pomarenski; Tim Klempan; Neil Ernst; Remi Quirion; Alain Gratton; Moshe Szyf; Gustavo Turecki
Alternative splicing, methylation state, and expression profile of tropomyosin-related kinase B in the frontal cortex of suicide completers.
Archives of general psychiatry 2009;66(1):22-32.
2009: Moshe Szyf
Epigenetics, DNA methylation, and chromatin modifying drugs.
Annual review of pharmacology and toxicology 2009;49():243-63.
2008: Samir K Patra; Moshe Szyf
DNA methylation-mediated nucleosome dynamics and oncogenic Ras signaling: insights from FAS, FAS ligand and RASSF1A.
The FEBS journal 2008;275(21):5217-35.
2008: Patrick O McGowan; Michael J Meaney; Moshe Szyf
Diet and the epigenetic (re)programming of phenotypic differences in behavior.
Brain research 2008;1237():12-24.
2008: Michael O Poulter; Lisheng Du; Ian C G Weaver; Miklós Palkovits; Gabor Faludi; Zul Merali; Moshe Szyf; Hymie Anisman
GABAA receptor promoter hypermethylation in suicide brain: implications for the involvement of epigenetic processes.
Biological psychiatry 2008;64(8):645-52.
2008: Carl Ernst; Patrick O McGowan; Vesselina Deleva; Michael J Meaney; Moshe Szyf; Gustavo Turecki
The effects of pH on DNA methylation state: In vitro and post-mortem brain studies.
Journal of neuroscience methods 2008;174(1):123-5.
2008: Shelley E Brown; Matthew J Suderman; Michael Hallett; Moshe Szyf
DNA demethylation induced by the methyl-CpG-binding domain protein MBD3.
Gene 2008;420(2):99-106.
2008: Shelley E Brown; Ian C G Weaver; Michael J Meaney; Moshe Szyf
Regional-specific global cytosine methylation and DNA methyltransferase expression in the adult rat hippocampus.
Neuroscience letters 2008;440(1):49-53.
2008: N M Cameron; D Shahrokh; A Del Corpo; Sabine Dhir; Moshe Szyf; Frances A Champagne; Michael J Meaney
Epigenetic programming of phenotypic variations in reproductive strategies in the rat through maternal care.
Journal of neuroendocrinology 2008;20(6):795-801.
2008: Moshe Szyf
DNA demethylation and cancer metastasis: therapeutic implications.
Expert opinion on drug discovery 2008;3(5):519-31.
2008: Moshe Szyf; Michael J Meaney
Epigenetics, behaviour, and health.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2008;4(1):37-49.
2008: Bushra Ateeq; Alexander Unterberger; Moshe Szyf; Shafaat A Rabbani
Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo.
Neoplasia (New York, N.Y.) 2008;10(3):266-78.
2008: Angela O Choi; Shelley E Brown; Moshe Szyf; Dusica Maysinger
Quantum dot-induced epigenetic and genotoxic changes in human breast cancer cells.
Journal of molecular medicine (Berlin, Germany) 2008;86(3):291-302.
2008: Shelley E Brown; Moshe Szyf
Dynamic epigenetic states of ribosomal RNA promoters during the cell cycle.
Cell cycle (Georgetown, Tex.) 2008;7(3):382-90.
2008: Stefan Hamm; George Just; Nathalie Lacoste; Nicolas Moitessier; Moshe Szyf; Orval Mamer
On the mechanism of demethylation of 5-methylcytosine in DNA.
Bioorganic & medicinal chemistry letters 2008;18(3):1046-9.
2008: Alexander Unterberger; jerome torrisani; Moshe Szyf
A method for purification, identification and validation of DNMT1 mRNA binding proteins.
Biological procedures online 2008;10():47-57.
2008: Patrick O McGowan; Aya Sasaki; Tony C T Huang; Alexander Unterberger; Matthew Suderman; Carl Ernst; Michael J Meaney; Gustavo Turecki; Moshe Szyf
Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain.
PloS one 2008;3(5):e2085.
2008: Moshe Szyf; Patrick McGowan; Michael J Meaney
The social environment and the epigenome.
Environmental and molecular mutagenesis 2008;49(1):46-60.
2007: Ana C D'Alessio; Ian C G Weaver; Moshe Szyf
Acetylation-induced transcription is required for active DNA demethylation in methylation-silenced genes.
Molecular and cellular biology 2007;27(21):7462-74.
2007: Moshe Szyf
The dynamic epigenome and its implications in toxicology.
Toxicological sciences : an official journal of the Society of Toxicology 2007;100(1):7-23.
2007: D N Arvanitis; Adriana Ducatenzeiler; J N Ou; E Grodstein; S D Andrews; Sachin R Tendulkar; Alfredo Ribeiro-da-Silva; Moshe Szyf; A Claudio Cuello
High intracellular concentrations of amyloid-beta block nuclear translocation of phosphorylated CREB.
Journal of neurochemistry 2007;103(1):216-28.
2007: Moshe Szyf; Ian C G Weaver; Michael Meaney
Maternal care, the epigenome and phenotypic differences in behavior.
Reproductive toxicology (Elmsford, N.Y.) 2007;24(1):9-19.
2007: Michael J Meaney; Moshe Szyf; Jonathan R Seckl
Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health.
Trends in molecular medicine 2007;13(7):269-77.
2007: Shelley E Brown; Moshe Szyf
Epigenetic programming of the rRNA promoter by MBD3.
Molecular and cellular biology 2007;27(13):4938-52.
2007: Jing-Ni Ou; jerome torrisani; Alexander Unterberger; Nadine Provençal; Keisuke Shikimi; Mohsen Karimi; Tomas J Ekström; Moshe Szyf
Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines.
Biochemical pharmacology 2007;73(9):1297-307.
2007: Anne Monique Nuyt; Moshe Szyf
Developmental programming through epigenetic changes.
Circulation research 2007;100(4):452-5.
2007: Snezana Milutinovic; Ana C D'Alessio; Nancy Detich; Moshe Szyf
Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes.
Carcinogenesis 2007;28(3):560-71.
2007: Ian C G Weaver; Ana C D'Alessio; Shelley E Brown; Ian C Hellstrom; Sergiy Dymov; Shakti Sharma; Moshe Szyf; Michael J Meaney
The transcription factor nerve growth factor-inducible protein a mediates epigenetic programming: altering epigenetic marks by immediate-early genes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(7):1756-68.
2007: Shelley E Brown; Mario F Fraga; Ian C G Weaver; Maria Berdasco; Moshe Szyf
Variations in DNA methylation patterns during the cell cycle of HeLa cells.
Epigenetics : official journal of the DNA Methylation Society 2007;2(1):54-65.
2007: jerome torrisani; Alexander Unterberger; Sachin R Tendulkar; Keisuke Shikimi; Moshe Szyf
AUF1 cell cycle variations define genomic DNA methylation by regulation of DNMT1 mRNA stability.
Molecular and cellular biology 2007;27(1):395-410.
2006: Alexander Unterberger; Stephen D Andrews; Ian C G Weaver; Moshe Szyf
DNA methyltransferase 1 knockdown activates a replication stress checkpoint.
Molecular and cellular biology 2006;26(20):7575-86.
2006: Nicholas Shukeir; Pouya Pakneshan; Gaoping Chen; Moshe Szyf; Shafaat A Rabbani
Alteration of the methylation status of tumor-promoting genes decreases prostate cancer cell invasiveness and tumorigenesis in vitro and in vivo.
Cancer research 2006;66(18):9202-10.
2006: Moshe Szyf
Targeting DNA methylation in cancer.
Bulletin du cancer 2006;93(9):961-72.
2006: Ana C D'Alessio; Moshe Szyf
Epigenetic tête-à-tête: the bilateral relationship between chromatin modifications and DNA methylation.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2006;84(4):463-76.
2006: Tie Yuan Zhang; Rose Bagot; Carine Parent; Cathy Nesbitt; Timothy W Bredy; Christian Caldji; Eric W Fish; Hymie Anisman; Moshe Szyf; Michael J Meaney
Maternal programming of defensive responses through sustained effects on gene expression.
Biological psychology 2006;73(1):72-89.
2006: Frances A Champagne; Ian C G Weaver; Josie Diorio; Sergiy Dymov; Moshe Szyf; Michael J Meaney
Maternal care associated with methylation of the estrogen receptor-alpha1b promoter and estrogen receptor-alpha expression in the medial preoptic area of female offspring.
Endocrinology 2006;147(6):2909-15.
2006: Ian C G Weaver; Michael J Meaney; Moshe Szyf
Maternal care effects on the hippocampal transcriptome and anxiety-mediated behaviors in the offspring that are reversible in adulthood.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3480-5.
2005: Ian C G Weaver; Frances A Champagne; Shelley E Brown; Sergiy Dymov; Shakti Sharma; Michael J Meaney; Moshe Szyf
Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(47):11045-54.
2005: Pouya Pakneshan; Moshe Szyf; Shafaat A Rabbani
Hypomethylation of urokinase (uPA) promoter in breast and prostate cancer: prognostic and therapeutic implications.
Current cancer drug targets 2005;5(7):471-88.
2005: Moshe Szyf; Ian C G Weaver; Frances A Champagne; Josie Diorio; Michael J Meaney
Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat.
Frontiers in neuroendocrinology 2005;26(3-4):139-62.
2005: Michael J Meaney; Moshe Szyf
Maternal care as a model for experience-dependent chromatin plasticity?
Trends in neurosciences 2005;28(9):456-63.
2005: Moshe Szyf
DNA methylation and demethylation as targets for anticancer therapy.
Biochemistry. Biokhimii͡a 2005;70(5):533-49.
2005: Pouya Pakneshan; Moshe Szyf; Shafaat A Rabbani
Methylation and inhibition of expression of uPA by the RAS oncogene: divergence of growth control and invasion in breast cancer cells.
Carcinogenesis 2005;26(3):557-64.
2005: Moshe Szyf
Therapeutic implications of DNA methylation.
Future oncology (London, England) 2005;1(1):125-35.
2005: Michael J Meaney; Moshe Szyf
Environmental programming of stress responses through DNA methylation: life at the interface between a dynamic environment and a fixed genome.
Dialogues in clinical neuroscience 2005;7(2):103-23.
2004: Freya Vercauteren; Stefan Clerens; Line Roy; Nathalie Hamel; Lutgarde Arckens; Frans Vandesand; Leena Alhonen; Juhani Janne; Moshe Szyf; A Claudio Cuello
Early dysregulation of hippocampal proteins in transgenic rats with Alzheimer's disease-linked mutations in amyloid precursor protein and presenilin 1.
Brain research. Molecular brain research 2004;132(2):241-59.
2004: Eric W Fish; Dara Shahrokh; Rose Bagot; Christian Caldji; Timothy W Bredy; Moshe Szyf; Michael J Meaney
Epigenetic programming of stress responses through variations in maternal care.
Annals of the New York Academy of Sciences 2004;1036():167-80.
2004: Moshe Szyf; Pouya Pakneshan; Shafaat A Rabbani
DNA methylation and breast cancer.
Biochemical pharmacology 2004;68(6):1187-97.
2004: Moshe Szyf; Pouya Pakneshan; Shafaat A Rabbani
DNA demethylation and cancer: therapeutic implications.
Cancer letters 2004;211(2):133-43.
2004: Ian C G Weaver; Nadia Cervoni; Frances A Champagne; Ana C D'Alessio; Shakti Sharma; Jonathan R Seckl; Sergiy Dymov; Moshe Szyf; Michael J Meaney
Epigenetic programming by maternal behavior.
Nature neuroscience 2004;7(8):847-54.
2004: Pouya Pakneshan; Moshe Szyf; Robin Farias-Eisner; Shafaat A Rabbani
Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis.
The Journal of biological chemistry 2004;279(30):31735-44.
2004: Snezana Milutinovic; Shelley E Brown; Qianli Zhuang; Moshe Szyf
DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation.
The Journal of biological chemistry 2004;279(27):27915-27.
2004: Ian C G Weaver; Josie Diorio; Jonathan R Seckl; Moshe Szyf; Michael J Meaney
Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites.
Annals of the New York Academy of Sciences 2004;1024():182-212.
2004: Valentina Echeverria Moran; Adriana Ducatenzeiler; Leena Alhonen; Juhani Janne; Susan M Grant; Francisco Wandosell; Andres Muro; Francisco Baralle; Hongshan Li; karen duff; Moshe Szyf; A Claudio Cuello
Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex.
Journal of Alzheimer's disease : JAD 2004;6(3):209-19.
2004: Paul M Campbell; Veronica Bovenzi; Moshe Szyf
Methylated DNA-binding protein 2 antisense inhibitors suppress tumourigenesis of human cancer cell lines in vitro and in vivo.
Carcinogenesis 2004;25(4):499-507.
2004: Valentina Echeverria Moran; Adriana Ducatenzeiler; E Dowd; J Jänne; Susan M Grant; Moshe Szyf; Francisco Wandosell; Jesús Avila; H Grimm; Stephen B Dunnett; Tobias Hartmann; Leena Alhonen; A Claudio Cuello
Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons.
Neuroscience 2004;129(3):583-92.
2003: Moshe Szyf
DNA methylation and cancer therapy.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2003;6(6):341-53.
2003: Marie-Agnès Ivanov; Badia Lamrihi; Moshe Szyf; Daniel Scherman; Pascal Bigey
Enhanced antitumor activity of a combination of MBD2-antisense electrotransfer gene therapy and bleomycin electrochemotherapy.
The journal of gene medicine 2003;5(10):893-9.
2003: Nancy Detich; Veronica Bovenzi; Moshe Szyf
Valproate induces replication-independent active DNA demethylation.
The Journal of biological chemistry 2003;278(30):27586-92.
2003: Moshe Szyf
Targeting DNA methylation in cancer.
Ageing research reviews 2003;2(3):299-328.
2003: Nancy Detich; Stefan Hamm; George Just; J David Knox; Moshe Szyf
The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine.
The Journal of biological chemistry 2003;278(23):20812-20.
2003: Snezana Milutinovic; Qianli Zhuang; Alain Niveleau; Moshe Szyf
Epigenomic stress response. Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes.
The Journal of biological chemistry 2003;278(17):14985-95.
2003: Paul M Campbell; Moshe Szyf
Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway.
Carcinogenesis 2003;24(1):17-24.
2002: Ian C G Weaver; Moshe Szyf; Michael J Meaney
From maternal care to gene expression: DNA methylation and the maternal programming of stress responses.
Endocrine research 2002;28(4):699.
2002: Yongjing Guo; Pouya Pakneshan; Julienne Gladu; Andrew Slack; Moshe Szyf; Shafaat A Rabbani
Regulation of DNA methylation in human breast cancer. Effect on the urokinase-type plasminogen activator gene production and tumor invasion.
The Journal of biological chemistry 2002;277(44):41571-9.
2002: Nancy Detich; Johanne Theberge; Moshe Szyf
Promoter-specific activation and demethylation by MBD2/demethylase.
The Journal of biological chemistry 2002;277(39):35791-4.
2002: Nadia Cervoni; Nancy Detich; Sang-Beom Seo; Debabrata Chakravarti; Moshe Szyf
The oncoprotein Set/TAF-1beta, an inhibitor of histone acetyltransferase, inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing.
The Journal of biological chemistry 2002;277(28):25026-31.
2002: Andrew Slack; Veronica Bovenzi; Pascal Bigey; M A Ivanov; Shyam Ramchandani; Sanjoy K Bhattacharya; Benjamin R Tenoever; B Lamrihi; Daniel Scherman; Moshe Szyf
Antisense MBD2 gene therapy inhibits tumorigenesis.
The journal of gene medicine 2002;4(4):381-9.
2002: Snezana Milutinovic; Qianli Zhuang; Moshe Szyf
Proliferating cell nuclear antigen associates with histone deacetylase activity, integrating DNA replication and chromatin modification.
The Journal of biological chemistry 2002;277(23):20974-8.
2002: Moshe Szyf
Utilization of antisense oligonucleotides to study the role of 5-cytosine DNA methyltransferase in cellular transformation and oncogenesis.
Methods (San Diego, Calif.) 2002;27(2):184-91.
2002: Moshe Szyf; Sanjoy K Bhattacharya
Extracting DNA demethylase activity from mammalian cells.
Methods in molecular biology (Clifton, N.J.) 2002;200():163-76.
2002: Moshe Szyf; Sanjoy K Bhattacharya
Measuring DNA demethylase activity in vitro.
Methods in molecular biology (Clifton, N.J.) 2002;200():155-61.
2001: Ian C G Weaver; P La Plante; S Weaver; Angèle T Parent; S Sharma; Josie Diorio; Karen E Chapman; Jonathan R Seckl; Moshe Szyf; Michael J Meaney
Early environmental regulation of hippocampal glucocorticoid receptor gene expression: characterization of intracellular mediators and potential genomic target sites.
Molecular and cellular endocrinology 2001;185(1-2):205-18.
2001: Nadia Cervoni; Moshe Szyf
Demethylase activity is directed by histone acetylation.
The Journal of biological chemistry 2001;276(44):40778-87.
2001: Nancy Detich; Shyam Ramchandani; Moshe Szyf
A conserved 3'-untranslated element mediates growth regulation of DNA methyltransferase 1 and inhibits its transforming activity.
The Journal of biological chemistry 2001;276(27):24881-90.
2001: Moshe Szyf
Towards a pharmacology of DNA methylation.
Trends in pharmacological sciences 2001;22(7):350-4.
2001: Andrew Slack; Minola Pinard; FD Araujo; Moshe Szyf
A novel regulatory element in the dnmt1 gene that responds to co-activation by Rb and c-Jun.
Gene 2001;268(1-2):87-96.
2001: Moshe Szyf
The role of DNA methyltransferase 1 in growth control.
Frontiers in bioscience : a journal and virtual library 2001;6():D599-609.
2001: FD Araujo; Sylvie Croteau; Andrew Slack; Snezana Milutinovic; Pascal Bigey; Gerald B Price; Maria Zannis-Hadjopoulos; M Zannis-Hajopoulos; Moshe Szyf
The DNMT1 target recognition domain resides in the N terminus.
The Journal of biological chemistry 2001;276(10):6930-6.
2001: Moshe Szyf; Nancy Detich
Regulation of the DNA methylation machinery and its role in cellular transformation.
Progress in nucleic acid research and molecular biology 2001;69():47-79.
2000: Susan M Grant; Adriana Ducatenzeiler; Moshe Szyf; A Claudio Cuello
Abeta immunoreactive material is present in several intracellular compartments in transfected, neuronally differentiated, P19 cells expressing the human amyloid beta-protein precursor.
Journal of Alzheimer's disease : JAD 2000;2(3-4):207-22.
2000: Moshe Szyf; Andrew Slack
Mechanisms of epigenetic silencing of the c21 gene in Y1 adrenocortical tumor cells.
Endocrine research 2000;26(4):921-30.
2000: Moshe Szyf
The DNA methylation machinery as a therapeutic target.
Current drug targets 2000;1(1):101-18.
2000: J David Knox; FD Araujo; Pascal Bigey; Andrew Slack; Gerald B Price; Maria Zannis-Hadjopoulos; Moshe Szyf
Inhibition of DNA methyltransferase inhibits DNA replication.
The Journal of biological chemistry 2000;275(24):17986-90.
2000: Moshe Szyf; D J Knox; Snezana Milutinovic; Andrew Slack; FD Araujo
How does DNA methyltransferase cause oncogenic transformation?
Annals of the New York Academy of Sciences 2000;910():156-74; discussion 175-7.
2000: Snezana Milutinovic; J David Knox; Moshe Szyf
DNA methyltransferase inhibition induces the transcription of the tumor suppressor p21(WAF1/CIP1/sdi1).
The Journal of biological chemistry 2000;275(9):6353-9.
2000: Pascal Bigey; Shyam Ramchandani; J Theberge; FD Araujo; Moshe Szyf
Transcriptional regulation of the human DNA Methyltransferase (dnmt1) gene.
Gene 2000;242(1-2):407-18.
1999: Susan M Grant; Anne Morinville; Dusica Maysinger; Moshe Szyf; A Claudio Cuello
Phosphorylation of mitogen-activated protein kinase is altered in neuroectodermal cells overexpressing the human amyloid precursor protein 751 isoform.
Brain research. Molecular brain research 1999;72(2):115-20.
1999: Andrew Slack; Nadia Cervoni; Minola Pinard; Moshe Szyf
Feedback regulation of DNA methyltransferase gene expression by methylation.
European journal of biochemistry / FEBS 1999;264(1):191-9.
1999: J Deng; Moshe Szyf
Downregulation of DNA (cytosine-5-)methyltransferase is a late event in NGF-induced PC12 cell differentiation.
Brain research. Molecular brain research 1999;71(1):23-31.
1999: Shyam Ramchandani; Sanjoy K Bhattacharya; Nadia Cervoni; Moshe Szyf
DNA methylation is a reversible biological signal.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(11):6107-12.
1999: Andrew Slack; Nadia Cervoni; Minola Pinard; Moshe Szyf
DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen.
The Journal of biological chemistry 1999;274(15):10105-12.
1999: FD Araujo; J David Knox; Shyam Ramchandani; R Pelletier; Pascal Bigey; G Price; Moshe Szyf; Maria Zannis-Hadjopoulos
Identification of initiation sites for DNA replication in the human dnmt1 (DNA-methyltransferase) locus.
The Journal of biological chemistry 1999;274(14):9335-41.
1999: Nadia Cervoni; Sanjoy K Bhattacharya; Moshe Szyf
DNA demethylase is a processive enzyme.
The Journal of biological chemistry 1999;274(13):8363-6.
1999: Pascal Bigey; J David Knox; Sylvie Croteau; Sanjoy K Bhattacharya; Jean-François Théberge; Moshe Szyf
Modified oligonucleotides as bona fide antagonists of proteins interacting with DNA. Hairpin antagonists of the human DNA methyltransferase.
The Journal of biological chemistry 1999;274(8):4594-606.
1999: Sanjoy K Bhattacharya; Shyam Ramchandani; Nadia Cervoni; Moshe Szyf
A mammalian protein with specific demethylase activity for mCpG DNA.
Nature 1999;397(6720):579-83.
1999: Susan M Grant; S L Shankar; Ruth Chalmers-Redman; William G Tatton; Moshe Szyf; A Claudio Cuello
Mitochondrial abnormalities in neuroectodermal cells stably expressing human amyloid precursor protein (hAPP751).
Neuroreport 1999;10(1):41-6.
1998: J Deng; Moshe Szyf
Multiple isoforms of DNA methyltransferase are encoded by the vertebrate cytosine DNA methyltransferase gene.
The Journal of biological chemistry 1998;273(36):22869-72.
1998: Moshe Szyf
Targeting DNA methyltransferase in cancer.
Cancer metastasis reviews 1998;17(2):219-31.
1998: FD Araujo; J David Knox; Moshe Szyf; Gerald B Price; Maria Zannis-Hadjopoulos
Concurrent replication and methylation at mammalian origins of replication.
Molecular and cellular biology 1998;18(6):3475-82.
1998: Shyam Ramchandani; Pascal Bigey; Moshe Szyf
Genomic structure of the human DNA methyltransferase gene.
Biological chemistry 1998;379(4-5):535-40.
1997: Shyam Ramchandani; A R MacLeod; Minola Pinard; E von Hofe; Moshe Szyf
Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(2):684-9.
1996: Moshe Szyf
The DNA methylation machinery as a target for anticancer therapy.
Pharmacology & therapeutics 1996;70(1):1-37.
1995: Moshe Szyf; J Theberge; V Bozovic
Ras induces a general DNA demethylation activity in mouse embryonal P19 cells.
The Journal of biological chemistry 1995;270(21):12690-6.
1995: A R MacLeod; J Rouleau; Moshe Szyf
Regulation of DNA methylation by the Ras signaling pathway.
The Journal of biological chemistry 1995;270(19):11327-37.
1995: A R MacLeod; Moshe Szyf
Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis.
The Journal of biological chemistry 1995;270(14):8037-43.
1995: J Rouleau; A R MacLeod; Moshe Szyf
Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway.
The Journal of biological chemistry 1995;270(4):1595-601.
1994: Moshe Szyf
DNA methylation properties: consequences for pharmacology.
Trends in pharmacological sciences 1994;15(7):233-8.
1993: M Quik; R Odeh; Jacynthe Philie; Moshe Szyf
Functional nicotinic receptor expression in mesodermal cells transfected with MyoD cDNA.
Neuroscience 1993;57(3):787-95.
1992: D S Milstone; S K Shaw; K L Parker; Moshe Szyf; Jonathan G Seidman
An element regulating adrenal-specific steroid 21-hydroxylase expression is located within the slp gene.
The Journal of biological chemistry 1992;267(30):21924-7.
1992: Moshe Szyf; J Rouleau; J Theberge; V Bozovic
Induction of myogenic differentiation by an expression vector encoding the DNA methyltransferase cDNA sequence in the antisense orientation.
The Journal of biological chemistry 1992;267(18):12831-6.
1992: H Abdel-Baset; V Bozovic; Moshe Szyf; Paul R Albert
Conditional transformation mediated via a pertussis toxin-sensitive receptor signalling pathway.
Molecular endocrinology (Baltimore, Md.) 1992;6(5):730-40.
1992: J Rouleau; G Tanigawa; Moshe Szyf
The mouse DNA methyltransferase 5'-region. A unique housekeeping gene promoter.
The Journal of biological chemistry 1992;267(11):7368-77.
1991: Moshe Szyf
DNA methylation patterns: an additional level of information?
Biochemistry and cell biology = Biochimie et biologie cellulaire 1991;69(12):764-7.
1991: Moshe Szyf; V Bozovic; G Tanigawa
Growth regulation of mouse DNA methyltransferase gene expression.
The Journal of biological chemistry 1991;266(16):10027-30.
1990: Moshe Szyf; G Tanigawa; P L McCarthy
A DNA signal from the Thy-1 gene defines de novo methylation patterns in embryonic stem cells.
Molecular and cellular biology 1990;10(8):4396-400.
1990: Moshe Szyf; D S Milstone; Bernard P Schimmer; K L Parker; Jonathan G Seidman
cis modification of the steroid 21-hydroxylase gene prevents its expression in the Y1 mouse adrenocortical tumor cell line.
Molecular endocrinology (Baltimore, Md.) 1990;4(8):1144-52.
1989: Moshe Szyf; Bernard P Schimmer; Jonathan G Seidman
Nucleotide-sequence-specific de novo methylation in a somatic murine cell line.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(18):6853-7.
1989: J D Handler; Bernard P Schimmer; T R Flynn; Moshe Szyf; D A Rice; K L Parker
Regulation of 21-hydroxylase gene expression.
Endocrine research 1989;15(1-2):31-47.
1988: J D Handler; Bernard P Schimmer; T R Flynn; Moshe Szyf; J G Seidman; K L Parker
An enhancer element and a functional cyclic AMP-dependent protein kinase are required for expression of adrenocortical 21-hydroxylase.
The Journal of biological chemistry 1988;263(26):13068-73.