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Thomas Szyperski

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Bharathwaj Sathyamoorthy; Kiran K Singarapu; Angel E Garcia; Thomas Szyperski
Protein conformational space populated in solution probed with aromatic residual dipolar (13) C-(1) H couplings.
Jeffrey L Mills; Gaetano T Montelione; Thomas B Acton; John K Everett; Rong Xiao; Thomas Szyperski
Solution NMR structure of the helicase associated domain BVU_0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA.
Kathryn A Manning; Bharathwaj Sathyamoorthy; Thomas Szyperski; Alexander Eletsky; Andrew S Murkin
Highly precise measurement of kinetic isotope effects using 1H-detected 2D [13C,1H]-HSQC NMR spectroscopy.

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All Publications

2013: Bharathwaj Sathyamoorthy; Kiran K Singarapu; Angel E Garcia; Thomas Szyperski
Protein conformational space populated in solution probed with aromatic residual dipolar (13) C-(1) H couplings.
Chembiochem : a European journal of chemical biology 2013;14(6):684-8.
2013: Jeffrey L Mills; Gaetano T Montelione; Thomas B Acton; John K Everett; Rong Xiao; Thomas Szyperski
Solution NMR structure of the helicase associated domain BVU_0683(627-691) from Bacteroides vulgatus provides first structural coverage for protein domain family PF03457 and indicates domain binding to DNA.
Journal of structural and functional genomics 2013;14(1):19-24.
2012: Kathryn A Manning; Bharathwaj Sathyamoorthy; Thomas Szyperski; Alexander Eletsky; Andrew S Murkin
Highly precise measurement of kinetic isotope effects using 1H-detected 2D [13C,1H]-HSQC NMR spectroscopy.
Journal of the American Chemical Society 2012;134(51):20589-92.
2012: Hanudatta S Atreya; Victor Beaumont; Garima Jaipuria; Bharathwaj Sathyamoorthy; Gabriele Varani; Thomas Szyperski
GFT projection NMR for efficient (1)H/ (13)C sugar spin system identification in nucleic acids.
Journal of biomolecular NMR 2012;54(4):337-42.
2012: Paolo F Rinaudo; Shehua Shen; Dinesh Sukumaran; Thomas Szyperski; Marcelle I Cedars; Erwin Garcia; Jia Hua; Uday Prabhu; Su Qian; Chris Andrews
(1)H NMR based profiling of spent culture media cannot predict success of implantation for day 3 human embryos.
Journal of assisted reproduction and genetics 2012;29(12):1435-42.
2012: Alexander Eletsky; Mi-Young Jeong; Hyung Kim; Hsiau-Wei Lee; Gaetano T Montelione; David J Pagliarini; James H Prestegard; Dennis R Winge; Rong Xiao; Thomas Szyperski
Solution NMR structure of yeast succinate dehydrogenase flavinylation factor Sdh5 reveals a putative Sdh1 binding site.
Biochemistry 2012;51(43):8475-7.
2012: James M Thompson; Gaohua Liu; Jeffrey L Mills; Gaetano T Montelione; Paolo Rossi; Nikolaos G Sgourakis; Thomas Szyperski; Yuefeng Tang; David Baker
Accurate protein structure modeling using sparse NMR data and homologous structure information.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(25):9875-80.
2012: Grant S Murphy; Thomas Szyperski; Mischa Machius; Michael J Miley; Jeffrey L Mills; Brian Kuhlman
Increasing sequence diversity with flexible backbone protein design: the complete redesign of a protein hydrophobic core.
Structure (London, England : 1993) 2012;20(6):1086-96.
2012: Alexander Eletsky; John K Everett; Barry Honig; Hsiau-Wei Lee; Gaetano T Montelione; Donald Petrey; James H Prestegard; Rong Xiao; Qiangfeng Cliff Zhang; Thomas B Acton; Thomas Szyperski
Solution NMR structures reveal unique homodimer formation by a winged helix-turn-helix motif and provide first structures for protein domain family PF10771.
Journal of structural and functional genomics 2012;13(1):1-7.
2012: Alexander Eletsky; John K Everett; Gaetano T Montelione; Thomas B Acton; Rong Xiao; Thomas Szyperski
Solution NMR structures reveal a distinct architecture and provide first structures for protein domain family PF04536.
Journal of structural and functional genomics 2012;13(1):9-14.
2012: Yibing Wu; Rong Xiao; Thomas B Acton; Fabian Dey; Markus Fischer; Gaetano T Montelione; Marco Punta; Burkhard Rost; Bharathwaj Sathyamoorthy; Arne Skerra; Thomas Szyperski
NMR structure of lipoprotein YxeF from Bacillus subtilis reveals a calycin fold and distant homology with the lipocalin Blc from Escherichia coli.
PloS one 2012;7(6):e37404.
2011: Arindam Ghosh; Yunfen He; Yibing Wu; Thomas Szyperski
Theory of mirrored time domain sampling for NMR spectroscopy.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2011;213(1):46-57.
2011: Alexander Eletsky; Gaetano T Montelione; William T Ruyechan; Thomas B Acton; Rong Xiao; Thomas Szyperski
Solution NMR structure of MED25(391-543) comprising the activator-interacting domain (ACID) of human mediator subunit 25.
Journal of structural and functional genomics 2011;12(3):159-66.
2011: Erwin Garcia; Chris Andrews; Jia Hua; Hyung L Kim; Dinesh K Sukumaran; Thomas Szyperski; Kunle Odunsi
Diagnosis of early stage ovarian cancer by 1H NMR metabonomics of serum explored by use of a microflow NMR probe.
Journal of proteome research 2011;10(4):1765-71.
2011: Thomas Szyperski; Jeffrey L Mills
NMR-based structural biology of proteins in supercooled water.
Journal of structural and functional genomics 2011;12(1):1-7.
2010: W Trent Franks; Hanudatta S Atreya; Thomas Szyperski; Chad M Rienstra
GFT projection NMR spectroscopy for proteins in the solid state.
Journal of biomolecular NMR 2010;48(4):213-23.
2010: James Love; Filippo Mancia; Lawrence Shapiro; Marco Punta; Burkhard Rost; Mark E Girvin; Da-Neng Wang; Ming Zhou; John F Hunt; Thomas Szyperski; Eric Gouaux; Roderick MacKinnon; Ann McDermott; Barry Honig; Masayori Inouye; Gaetano T Montelione; Wayne A Hendrickson
The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins.
Journal of structural and functional genomics 2010;11(3):191-9.
2010: Ramesh K Jha; Andrew Leaver-Fay; Shuangye Yin; Yibing Wu; Glenn L Butterfoss; Thomas Szyperski; Nikolay V Dokholyan; Brian Kuhlman
Computational design of a PAK1 binding protein.
Journal of molecular biology 2010;400(2):257-70.
2010: Gaetano T Montelione; Thomas Szyperski
Advances in protein NMR provided by the NIGMS Protein Structure Initiative: impact on drug discovery.
Current opinion in drug discovery & development 2010;13(3):335-49.
2010: Srivatsan Raman; oliver lange; Paolo Rossi; Michael Tyka; Xu Wang; James Aramini; Gaohua Liu; Theresa A Ramelot; Alexander Eletsky; Thomas Szyperski; Michael A Kennedy; James H Prestegard; Gaetano T Montelione; David Baker
NMR structure determination for larger proteins using backbone-only data.
Science (New York, N.Y.) 2010;327(5968):1014-8.
2010: Kiran Kumar Singarapu; Jeffrey L Mills; Rong Xiao; Thomas B Acton; Marco Punta; Markus Fischer; Barry Honig; Burkhard Rost; Gaetano T Montelione; Thomas Szyperski
Solution NMR structures of proteins VPA0419 from Vibrio parahaemolyticus and yiiS from Shigella flexneri provide structural coverage for protein domain family PFAM 04175.
Proteins 2010;78(3):779-84.
2009: Dinesh K Sukumaran; Erwin Garcia; Jia Hua; Walter Tabaczynski; Kunle Odunsi; Chris Andrews; Thomas Szyperski
Standard operating procedure for metabonomics studies of blood serum and plasma samples using a 1H-NMR micro-flow probe.
Magnetic resonance in chemistry : MRC 2009;47 Suppl 1():S81-5.
2009: Rhiju Das; Ingemar André; Yang Shen; Yibing Wu; Alexander Lemak; Sonal Bansal; Cheryl H Arrowsmith; Thomas Szyperski; David Baker
Simultaneous prediction of protein folding and docking at high resolution.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(45):18978-83.
2009: Yibing Wu; Arindam Ghosh; Thomas Szyperski
Clean absorption mode NMR data acquisition based on time-proportional phase incrementation.
Journal of structural and functional genomics 2009;10(3):227-32.
2009: Alexander Eletsky; Dinesh K Sukumaran; Rong Xiao; Thomas B Acton; Burkhard Rost; Gaetano T Montelione; Thomas Szyperski
NMR structure of protein YvyC from Bacillus subtilis reveals unexpected structural similarity between two PFAM families.
Proteins 2009;76(4):1037-41.
2009: Jeffrey L Mills; Gaohua Liu; Arne Skerra; Thomas Szyperski
NMR structure and dynamics of the engineered fluorescein-binding lipocalin FluA reveal rigidification of beta-barrel and variable loops upon enthalpy-driven ligand binding.
Biochemistry 2009;48(31):7411-9.
2009: Shinobu Yamamoto; Alexander Eletsky; Thomas Szyperski; John Hay; William T Ruyechan
Analysis of the varicella-zoster virus IE62 N-terminal acidic transactivating domain and its interaction with the human mediator complex.
Journal of virology 2009;83(12):6300-5.
2009: Gaetano T Montelione; Cheryl Arrowsmith; Mark E Girvin; Michael A Kennedy; John Lute Markley; Robert Powers; James H Prestegard; Thomas Szyperski
Unique opportunities for NMR methods in structural genomics.
Journal of structural and functional genomics 2009;10(2):101-6.
2009: Gaohua Liu; Farhad Forouhar; Alexander Eletsky; Hanudatta S Atreya; James M Aramini; Rong Xiao; Yuanpeng J Huang; Mariam Abashidze; Jayaraman Seetharaman; Jinfeng Liu; Burkhard Rost; Thomas B Acton; Gaetano T Montelione; John F Hunt; Thomas Szyperski
NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway.
Journal of structural and functional genomics 2009;10(2):127-36.
2009: Yibing Wu; Arindam Ghosh; Thomas Szyperski
Clean absorption-mode NMR data acquisition.
Angewandte Chemie (International ed. in English) 2009;48(8):1479-83.
2008: David Parish; Jordi Benach; Goahua Liu; Kiran Kumar Singarapu; Rong Xiao; Thomas B Acton; Min Su; Sonal Bansal; James H Prestegard; John Hunt; Gaetano T Montelione; Thomas Szyperski
Protein chaperones Q8ZP25_SALTY from Salmonella typhimurium and HYAE_ECOLI from Escherichia coli exhibit thioredoxin-like structures despite lack of canonical thioredoxin active site sequence motif.
Journal of structural and functional genomics 2008;9(1-4):41-9.
2008: David A Snyder; Arindam Ghosh; Fengli Zhang; Thomas Szyperski; Rafael Brüschweiler
Z-matrix formalism for quantitative noise assessment of covariance nuclear magnetic resonance spectra.
The Journal of chemical physics 2008;129(10):104511.
2008: Kiran Kumar Singarapu; Rong Xiao; Thomas B Acton; Burkhard Rost; Gaetano T Montelione; Thomas Szyperski
NMR structure of the peptidyl-tRNA hydrolase domain from Pseudomonas syringae expands the structural coverage of the hydrolysis domains of class 1 peptide chain release factors.
Proteins 2008;71(2):1027-31.
2008: David M Parish; Thomas Szyperski
Simultaneously cycled NMR spectroscopy.
Journal of the American Chemical Society 2008;130(14):4925-33.
2008: Yang Shen; oliver lange; Frank Delaglio; Paolo Rossi; James M Aramini; Gaohua Liu; Alexander Eletsky; Yibing Wu; Kiran K Singarapu; Alexander Lemak; Alexandr Ignatchenko; Cheryl H Arrowsmith; Thomas Szyperski; Gaetano T Montelione; David Baker; Adriaan Bax
Consistent blind protein structure generation from NMR chemical shift data.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(12):4685-90.
2008: Qi Zhang; Hanudatta S Atreya; Douglas E. Kamen; Mark E Girvin; Thomas Szyperski
GFT projection NMR based resonance assignment of membrane proteins: application to subunit C of E. coli F(1)F (0) ATP synthase in LPPG micelles.
Journal of biomolecular NMR 2008;40(3):157-63.
2008: Kiran Kumar Singarapu; Rong Xiao; Dinesh K Sukumaran; Thomas B Acton; Gaetano T Montelione; Thomas Szyperski
NMR structure of protein Cgl2762 from Corynebacterium glutamicum implicated in DNA transposition reveals a helix-turn-helix motif attached to a flexibly disordered leucine zipper.
Proteins 2008;70(4):1650-4.
2008: Minfeng Li; Kazuhiro Yamato; Joseph Ferguson; Kiran Kumar Singarapu; Thomas Szyperski; Bing Gong
Sequence-specific, dynamic covalent crosslinking in aqueous media.
Journal of the American Chemical Society 2008;130(2):491-500.
2008: Yang Shen; Thomas Szyperski
Structure of the protein BPTI derived with NOESY in supercooled water: validation and refinement of solution structures.
Angewandte Chemie (International ed. in English) 2008;47(2):324-6.
2007: Kiran Kumar Singarapu; Gaohua Liu; Rong Xiao; Claudia Bertonati; Barry Honig; Gaetano T Montelione; Thomas Szyperski
NMR structure of protein yjbR from Escherichia coli reveals 'double-wing' DNA binding motif.
Proteins 2007;67(2):501-4.
2007: Hanudatta S Atreya; Erwin Garcia; Yang Shen; Thomas Szyperski
J-GFT NMR for precise measurement of mutually correlated nuclear spin-spin couplings.
Journal of the American Chemical Society 2007;129(3):680-92.
2007: Aina Solà; Paula Jouhten; Hannu Maaheimo; Francesc Sánchez-Ferrando; Thomas Szyperski; Pau Ferrer
Metabolic flux profiling of Pichia pastoris grown on glycerol/methanol mixtures in chemostat cultures at low and high dilution rates.
Microbiology (Reading, England) 2007;153(Pt 1):281-90.
2006: Yu-Chieh Lin; Gaohua Liu; Yang Shen; Claudia Bertonati; Adelinda Yee; Barry Honig; Cheryl H Arrowsmith; Thomas Szyperski
NMR structure of protein PA2021 from Pseudomonas aeruginosa.
Proteins 2006;65(3):767-70.
2006: Thomas Szyperski; Hanudatta S Atreya
Principles and applications of GFT projection NMR spectroscopy.
Magnetic resonance in chemistry : MRC 2006;44 Spec No():S51-60.
2006: Thomas Szyperski; Jeffrey L Mills; Dieter Perl; Jochen Balbach
Combined NMR-observation of cold denaturation in supercooled water and heat denaturation enables accurate measurement of deltaC(p) of protein unfolding.
European biophysics journal : EBJ 2006;35(4):363-6.
2006: Sulakshana Mukherjee; Dasari Muralidhar; Hanudatta S Atreya; Thomas Szyperski; Andreas Jeromin; Yogendra Sharma; Kandala V R Chary
1H, 13C, and 15N chemical shift assignments of neuronal calcium sensor-1, a multi-functional calcium-binding protein.
Journal of biomolecular NMR 2006;36 Suppl 1():48.
2006: Gaohua Liu; Yang Shen; Rong Xiao; Thomas B Acton; Li Chung Ma; Andrzej Joachimiak; Gaetano T Montelione; Thomas Szyperski
NMR structure of protein yqbG from Bacillus subtilis reveals a novel alpha-helical protein fold.
Proteins 2006;62(1):288-91.
2005: Alexander Eletsky; Hanudatta S Atreya; Gaohua Liu; Thomas Szyperski
Probing structure and functional dynamics of (large) proteins with aromatic rings: L-GFT-TROSY (4,3)D HCCH NMR spectroscopy.
Journal of the American Chemical Society 2005;127(42):14578-9.
2005: Antonio Pineda-Lucena; Cynthia S W Ho; Daniel Y L Mao; Yi Sheng; Rob Laister; Ranjith Muhandiram; Ying Lu; Bruce Seet; Sigal Katz; Thomas Szyperski; Linda Z Penn; Cheryl H Arrowsmith
A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants.
Journal of molecular biology 2005;351(1):182-94.
2005: Gaohua Liu; Yang Shen; Hanudatta S Atreya; David Parish; Ying Shao; Dinesh K Sukumaran; Rong Xiao; Adelinda Yee; Alexander Lemak; Aneerban Bhattacharya; Thomas A Acton; Cheryl H Arrowsmith; Gaetano T Montelione; Thomas Szyperski
NMR data collection and analysis protocol for high-throughput protein structure determination.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(30):10487-92.
2005: Gaohua Liu; James M Aramini; Hanudatta S Atreya; Alexander Eletsky; Rong Xiao; Thomas B Acton; LiChung Ma; Gaetano T Montelione; Thomas Szyperski
GFT NMR based resonance assignment for the 21 kDa human protein UFC1.
Journal of biomolecular NMR 2005;32(3):261.
2005: Yang Shen; Hanudatta S Atreya; Gaohua Liu; Thomas Szyperski
G-matrix Fourier transform NOESY-based protocol for high-quality protein structure determination.
Journal of the American Chemical Society 2005;127(25):9085-99.
2005: Gaohua Liu; Zhaohui Li; Yiwen Chiang; Thomas B Acton; Gaetano T Montelione; Diana Murray; Thomas Szyperski
High-quality homology models derived from NMR and X-ray structures of E. coli proteins YgdK and Suf E suggest that all members of the YgdK/Suf E protein family are enhancers of cysteine desulfurases.
Protein science : a publication of the Protein Society 2005;14(6):1597-608.
2005: Hanudatta S Atreya; Alexander Eletsky; Thomas Szyperski
Resonance assignment of proteins with high shift degeneracy based on 5D spectral information encoded in G2FT NMR experiments.
Journal of the American Chemical Society 2005;127(13):4554-5.
2005: Yang Shen; Sharon Goldsmith-Fischman; Hanudatta S Atreya; Thomas B Acton; LiChung Ma; Rong Xiao; Barry Honig; Gaetano T Montelione; Thomas Szyperski
NMR structure of the 18 kDa protein CC1736 from Caulobacter crescentus identifies a member of the START domain superfamily and suggests residues mediating substrate specificity.
Proteins 2005;58(3):747-50.
2005: Catherine Hervé du Penhoat; Zhaohui Li; Hanudatta S Atreya; Seho Kim; Adelinda Yee; Rong Xiao; Diana Murray; Cheryl H Arrowsmith; Thomas Szyperski
NMR solution structure of Thermotoga maritima protein TM1509 reveals a Zn-metalloprotease-like tertiary structure.
Journal of structural and functional genomics 2005;6(1):51-62.
2005: Yuanpeng J Huang; Hunter N B Moseley; Michael C Baran; Cheryl Arrowsmith; Robert Powers; Roberto Tejero; Thomas Szyperski; Gaetano T Montelione
An integrated platform for automated analysis of protein NMR structures.
Methods in enzymology 2005;394():111-41.
2005: Hanudatta S Atreya; Thomas Szyperski
Rapid NMR data collection.
Methods in enzymology 2005;394():78-108.
2004: Lihua Yuan; Huaqiang Zeng; Kazuhiro Yamato; Adam R Sanford; Wen Feng; Hanudatta S Atreya; Dinesh K Sukumaran; Thomas Szyperski; Bing Gong
Helical aromatic oligoamides: reliable, readily predictable folding from the combination of rigidified structural motifs.
Journal of the American Chemical Society 2004;126(50):16528-37.
2004: Nicola Zamboni; Hannu Maaheimo; Thomas Szyperski; Hans-Peter Hohmann; Uwe Sauer
The phosphoenolpyruvate carboxykinase also catalyzes C3 carboxylation at the interface of glycolysis and the TCA cycle of Bacillus subtilis.
Metabolic engineering 2004;6(4):277-84.
2004: Hunter N B Moseley; Nadeem Riaz; James M Aramini; Thomas Szyperski; Gaetano T Montelione
A generalized approach to automated NMR peak list editing: application to reduced dimensionality triple resonance spectra.
Journal of magnetic resonance (San Diego, Calif. : 1997) 2004;170(2):263-77.
2004: Yang Shen; Hanudatta S Atreya; Rong Xiao; Thomas B Acton; Ritu Shastry; LiChung Ma; Gaetano T Montelione; Thomas Szyperski
Resonance assignments for the 18 kDa protein CC1736 from Caulobacter crescentus.
Journal of biomolecular NMR 2004;29(4):549-50.
2004: Hanudatta S Atreya; Thomas Szyperski
G-matrix Fourier transform NMR spectroscopy for complete protein resonance assignment.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(26):9642-7.
2004: Aina Solà; Hannu Maaheimo; Katri Ylönen; Pau Ferrer; Thomas Szyperski
Amino acid biosynthesis and metabolic flux profiling of Pichia pastoris.
European journal of biochemistry / FEBS 2004;271(12):2462-70.
2004: Gaohua Liu; Dinesh K Sukumaran; Duanxiang Xu; Yiwen Chiang; Thomas B Acton; Sharon Goldsmith-Fischman; Barry Honig; Gaetano T Montelione; Thomas Szyperski
NMR structure of the hypothetical protein NMA1147 from Neisseria meningitidis reveals a distinct 5-helix bundle.
Proteins 2004;55(3):756-8.
2004: Catherine Herve du Penhoat; Hanudatta S Atreya; Yang Shen; Gaohua Liu; Thomas B Acton; Rong Xiao; Zhaohui Li; Diana Murray; Gaetano T Montelione; Thomas Szyperski
The NMR solution structure of the 30S ribosomal protein S27e encoded in gene RS27_ARCFU of Archaeoglobus fulgidis reveals a novel protein fold.
Protein science : a publication of the Protein Society 2004;13(5):1407-16.
2004: Duanxiang Xu; Gaohua Liu; Rong Xiao; Thomas B Acton; Sharon Goldsmith-Fischman; Barry Honig; Gaetano T Montelione; Thomas Szyperski
NMR structure of the hypothetical protein AQ-1857 encoded by the Y157 gene from Aquifex aeolicus reveals a novel protein fold.
Proteins 2004;54(4):794-6.
2004: Seho Kim; Thomas Szyperski
GFT NMR experiments for polypeptide backbone and 13Cbeta chemical shift assignment.
Journal of biomolecular NMR 2004;28(2):117-30.
2004: Daniel Monleon; Yiwen Chiang; James M Aramini; G V T Swapna; Daphne Macapagal; Kristin C Gunsalus; Seho Kim; Thomas Szyperski; Gaetano T Montelione
Backbone 1H, 15N and 13C assignments for the 21 kDa Caenorhabditis elegans homologue of "brain-specific" protein.
Journal of biomolecular NMR 2004;28(1):91-2.
2003: James M Aramini; Jeffrey L Mills; Rong Xiao; Thomas B Acton; Maggie J Wu; Thomas Szyperski; Gaetano T Montelione
Resonance assignments for the hypothetical protein yggU from Escherichia coli.
Journal of biomolecular NMR 2003;27(3):285-6.
2003: Gaohua Liu; Jeffrey L Mills; Tracy A Hess; Seho Kim; Jack J Skalicky; Dinesh K Sukumaran; Eriks Kupce; Arne Skerra; Thomas Szyperski
Resonance assignments for the 21 kDa engineered fluorescein-binding lipocalin FluA.
Journal of biomolecular NMR 2003;27(2):187-8.
2003: Dalia Daujotyte; Giedrius Vilkaitis; Laura Manelyte; Jack Skalicky; Thomas Szyperski; Saulius Klimasauskas
Solubility engineering of the HhaI methyltransferase.
Protein engineering 2003;16(4):295-301.
2003: Seho Kim; Thomas Szyperski
GFT NMR, a new approach to rapidly obtain precise high-dimensional NMR spectral information.
Journal of the American Chemical Society 2003;125(5):1385-93.
2003: Jocelyne Fiaux; Z Petek Cakar; Marco Sonderegger; Kurt Wüthrich; Thomas Szyperski; Uwe Sauer
Metabolic-flux profiling of the yeasts Saccharomyces cerevisiae and Pichia stipitis.
Eukaryotic cell 2003;2(1):170-80.
2002: Bing Gong; Huaqiang Zeng; Jin Zhu; Lihua Yuan; Yaohua Han; Shizhi Cheng; Mako Furukawa; Rubén D Parra; Andrey Yu Kovalevsky; Jeffrey L Mills; Ewa Skrzypczak-Jankun; Suzana Martinovic; Richard D Smith; Chong Zheng; Thomas Szyperski; Xiao Cheng Zeng; Lihua Yua
Creating nanocavities of tunable sizes: hollow helices.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(18):11583-8.
2002: Youlin Xia; Cheryl H Arrowsmith; Thomas Szyperski
Novel projected 4D triple resonance experiments for polypeptide backbone chemical shift assignment.
Journal of biomolecular NMR 2002;24(1):41-50.
2002: Thomas Szyperski; Deok C Yeh; Dinesh K Sukumaran; Hunter N B Moseley; Gaetano T Montelione
Reduced-dimensionality NMR spectroscopy for high-throughput protein resonance assignment.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(12):8009-14.
2002: Jeffrey L Mills; Thomas Szyperski
Protein dynamics in supercooled water: the search for slow motional modes.
Journal of biomolecular NMR 2002;23(1):63-7.
2002: Michael Dauner; Marco Sonderegger; Michel Hochuli; Thomas Szyperski; Kurt Wüthrich; Hans-Peter Hohmann; Uwe Sauer; James E Bailey
Intracellular carbon fluxes in riboflavin-producing Bacillus subtilis during growth on two-carbon substrate mixtures.
Applied and environmental microbiology 2002;68(4):1760-71.
2002: Blair Szymczyna; Antonio Pineda-Lucena; Jeffrey L Mills; Thomas Szyperski; Cheryl H Arrowsmith
1H, 13C, and 15N resonance assignments and secondary structure of the PWI domain from SRm160 using reduced dimensionality NMR.
Journal of biomolecular NMR 2002;22(3):299-300.
2002: Daniel Monleon; Kimberly Colson; Hunter N B Moseley; Clemens Anklin; Robert Oswald; Thomas Szyperski; Gaetano T Montelione
Rapid analysis of protein backbone resonance assignments using cryogenic probes, a distributed Linux-based computing architecture, and an integrated set of spectral analysis tools.
Journal of structural and functional genomics 2002;2(2):93-101.
2002: Marcel Emmerling; Michael Dauner; Aaron Ponti; Jocelyne Fiaux; Michel Hochuli; Thomas Szyperski; Kurt Wüthrich; James E Bailey; Uwe Sauer
Metabolic flux responses to pyruvate kinase knockout in Escherichia coli.
Journal of bacteriology 2002;184(1):152-64.
2001: Fabrizio Canonaco; T A Hess; S Heri; T Wang; Thomas Szyperski; Uwe Sauer
Metabolic flux response to phosphoglucose isomerase knock-out in Escherichia coli and impact of overexpression of the soluble transhydrogenase UdhA.
FEMS microbiology letters 2001;204(2):247-52.
2001: Hannu Maaheimo; Jocelyne Fiaux; Z Petek Cakar; James E Bailey; Uwe Sauer; Thomas Szyperski
Central carbon metabolism of Saccharomyces cerevisiae explored by biosynthetic fractional (13)C labeling of common amino acids.
European journal of biochemistry / FEBS 2001;268(8):2464-79.
2001: Alexander D Frey; Jocelyne Fiaux; Thomas Szyperski; Kurt Wüthrich; James E Bailey; Pauli T Kallio
Dissection of central carbon metabolism of hemoglobin-expressing Escherichia coli by 13C nuclear magnetic resonance flux distribution analysis in microaerobic bioprocesses.
Applied and environmental microbiology 2001;67(2):680-7.
2001: J J Skalicky; J L Mills; S Sharma; Thomas Szyperski
Aromatic ring-flipping in supercooled water: implications for NMR-based structural biology of proteins.
Journal of the American Chemical Society 2001;123(3):388-97.
2000: Gaetano T Montelione; Deyou Zheng; Y J Huang; Kristin C Gunsalus; Thomas Szyperski
Protein NMR spectroscopy in structural genomics.
Nature structural biology 2000;7 Suppl():982-5.
2000: Michel Hochuli; Thomas Szyperski; Kurt Wüthrich
Deuterium isotope effects on the central carbon metabolism of Escherichia coli cells grown on a D2O-containing minimal medium.
Journal of biomolecular NMR 2000;17(1):33-42.
2000: F L García; Thomas Szyperski; JH Dyer; Thomas Choinowski; U Seedorf; Helmut Hauser; Kurt Wüthrich
NMR structure of the sterol carrier protein-2: implications for the biological role.
Journal of molecular biology 2000;295(3):595-603.
1999: Uwe Sauer; DR Lasko; Jocelyne Fiaux; Michel Hochuli; R Glaser; Thomas Szyperski; Kurt Wüthrich; James E Bailey
Metabolic flux ratio analysis of genetic and environmental modulations of Escherichia coli central carbon metabolism.
Journal of bacteriology 1999;181(21):6679-88.
1999: Thomas Szyperski; César Fernández; A Ono; Kurt Wüthrich; M Kainosho
The 2D [31P] spin-echo-difference constant-time [13C, 1H]-HMQC experiment for simultaneous determination of 3J(H3'P) and 3J(C4'P) in 13C-labeled nucleic acids and their protein complexes.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1999;140(2):491-4.
1999: César Fernández; Thomas Szyperski; M Billeter; A Ono; H Iwai; M Kainosho; Kurt Wüthrich
Conformational changes of the BS2 operator DNA upon complex formation with the Antennapedia homeodomain studied by NMR with 13C/15N-labeled DNA.
Journal of molecular biology 1999;292(3):609-17.
1999: Thomas Szyperski; R W Glaser; Michel Hochuli; Jocelyne Fiaux; Uwe Sauer; James E Bailey; Kurt Wüthrich
Bioreaction network topology and metabolic flux ratio analysis by biosynthetic fractional 13C labeling and two-dimensional NMR spectroscopy.
Metabolic engineering 1999;1(3):189-97.
1999: Michel Hochuli; Holger Patzelt; Dieter Oesterhelt; Kurt Wüthrich; Thomas Szyperski
Amino acid biosynthesis in the halophilic archaeon Haloarcula hispanica.
Journal of bacteriology 1999;181(10):3226-37.
1999: Thomas Szyperski; Matthias Götte; M Billeter; E Perola; Luciano Cellai; Hermann Heumann; Kurt Wüthrich
NMR structure of the chimeric hybrid duplex r(gcaguggc).r(gcca)d(CTGC) comprising the tRNA-DNA junction formed during initiation of HIV-1 reverse transcription.
Journal of biomolecular NMR 1999;13(4):343-55.
1998: Thomas Szyperski; G Vandenbussche; Tore Curstedt; Jean-Marie Ruysschaert; Kurt Wüthrich; Jan Johansson
Pulmonary surfactant-associated polypeptide C in a mixed organic solvent transforms from a monomeric alpha-helical state into insoluble beta-sheet aggregates.
Protein science : a publication of the Protein Society 1998;7(12):2533-40.
1998: Konstantin Pervushin; A Ono; César Fernández; Thomas Szyperski; M Kainosho; Kurt Wüthrich
NMR scalar couplings across Watson-Crick base pair hydrogen bonds in DNA observed by transverse relaxation-optimized spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14147-51.
1998: César Fernández; Thomas Szyperski; A Ono; H Iwai; S Tate; M Kainosho; Kurt Wüthrich
NMR with (13)C, (15)N-doubly-labeled DNA: The shape Antennapedia homeodomain complex with a 14-mer DNA duplex.
Journal of biomolecular NMR 1998;12(1):25-37.
1998: César Fernández; Thomas Szyperski; A Ono; H Iwai; S Tate; M Kainosho; Kurt Wüthrich
NMR with 13C, 15N-doubly-labeled DNA: the Antennapedia homeodomain complex with a 14-mer DNA duplex.
Journal of biomolecular NMR 1998;12(1):25-37.
1998: Franz Weber; JH Dyer; F López García; martin werder; Thomas Szyperski; Kurt Wüthrich; Helmut Hauser
In pre-sterol carrier protein 2 (SCP2) in solution the leader peptide 1-20 is flexibly disordered, and residues 21-143 adopt the same globular fold as in mature SCP2.
Cellular and molecular life sciences : CMLS 1998;54(7):751-9.
1998: Thomas Szyperski; César Fernández; C Mumenthaler; Kurt Wüthrich
Structure comparison of human glioma pathogenesis-related protein GliPR and the plant pathogenesis-related protein P14a indicates a functional link between the human immune system and a plant defense system.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(5):2262-6.
1998: Thomas Szyperski
13C-NMR, MS and metabolic flux balancing in biotechnology research.
Quarterly reviews of biophysics 1998;31(1):41-106.
1998: Saulius Klimasauskas; Thomas Szyperski; Saulius Serva; Kurt Wüthrich
Dynamic modes of the flipped-out cytosine during HhaI methyltransferase-DNA interactions in solution.
The EMBO journal 1998;17(1):317-24.
1997: Thomas Szyperski; César Fernández; Kurt Wüthrich
Two-dimensional ct-HC(C)H-COSY for resonance assignments of smaller 13C-labeled biomolecules.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1997;128(2):228-32.
1997: Uwe Sauer; Vassily Hatzimanikatis; James E Bailey; Michel Hochuli; Thomas Szyperski; Kurt Wüthrich
Metabolic fluxes in riboflavin-producing Bacillus subtilis.
Nature biotechnology 1997;15(5):448-52.
1997: César Fernández; Thomas Szyperski; T Bruyère; P Ramage; E Mösinger; Kurt Wüthrich
NMR solution structure of the pathogenesis-related protein P14a.
Journal of molecular biology 1997;266(3):576-93.
1997: M Pellecchia; H Iwai; Thomas Szyperski; Kurt Wüthrich
The 2D NMR experiments H(C)CO2 and HCCO2 for assignment and pH titration of carboxylate groups in uniformly 15N/13C-labeled proteins.
Journal of magnetic resonance (San Diego, Calif. : 1997) 1997;124(1):274-8.
1996: M Pellecchia; Thomas Szyperski; D Wall; C Georgopoulos; Kurt Wüthrich
NMR structure of the J-domain and the Gly/Phe-rich region of the Escherichia coli DnaJ chaperone.
Journal of molecular biology 1996;260(2):236-50.
1996: Oliver Zerbe; M Ottiger; Thomas Szyperski; Kurt Wüthrich
Three-dimensional (1)H-TOCSY-relayed ct-[(13)C, (1)H]-HMQC for aromatic spin system identification in uniformly (13)C-labeled proteins.
Journal of biomolecular NMR 1996;7(2):99-106.
1995: Thomas Szyperski
Biosynthetically directed fractional 13C-labeling of proteinogenic amino acids. An efficient analytical tool to investigate intermediary metabolism.
European journal of biochemistry / FEBS 1995;232(2):433-48.
1995: J Johansson; Thomas Szyperski; Kurt Wüthrich
Pulmonary surfactant-associated polypeptide SP-C in lipid micelles: CD studies of intact SP-C and NMR secondary structure determination of depalmitoyl-SP-C(1-17).
FEBS letters 1995;362(3):261-5.
1994: Thomas Szyperski; M Pellecchia; D Wall; C Georgopoulos; Kurt Wüthrich
NMR structure determination of the Escherichia coli DnaJ molecular chaperone: secondary structure and backbone fold of the N-terminal region (residues 2-108) containing the highly conserved J domain.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(24):11343-7.
1994: M Ottiger; Thomas Szyperski; P Luginbühl; C Ortenzi; P Luporini; Ralph A Bradshaw; Kurt Wüthrich
The NMR solution structure of the pheromone Er-2 from the ciliated protozoan Euplotes raikovi.
Protein science : a publication of the Protein Society 1994;3(9):1515-26.
1994: Thomas Szyperski; W Antuch; M Schick; A Betz; S R Stone; Kurt Wüthrich
Transient hydrogen bonds identified on the surface of the NMR solution structure of Hirudin.
Biochemistry 1994;33(31):9303-10.
1994: J Johansson; Thomas Szyperski; T Curstedt; Kurt Wüthrich
The NMR structure of the pulmonary surfactant-associated polypeptide SP-C in an apolar solvent contains a valyl-rich alpha-helix.
Biochemistry 1994;33(19):6015-23.
1993: Thomas Szyperski; S Scheek; J Johansson; G Assmann; U Seedorf; Kurt Wüthrich
NMR determination of the secondary structure and the three-dimensional polypeptide backbone fold of the human sterol carrier protein 2.
FEBS letters 1993;335(1):18-26.
1993: Thomas Szyperski; P Luginbühl; Gottfried Otting; Peter Güntert; Kurt Wüthrich
Protein dynamics studied by rotating frame 15N spin relaxation times.
Journal of biomolecular NMR 1993;3(2):151-64.
1993: Thomas Szyperski; Gerhard Wider; J H Bushweller; Kurt Wüthrich
3D 13C-15N-heteronuclear two-spin coherence spectroscopy for polypeptide backbone assignments in 13C-15N-double-labeled proteins.
Journal of biomolecular NMR 1993;3(1):127-32.
1992: Thomas Szyperski; Peter Güntert; S R Stone; A Tulinsky; W Bode; Robert Huber; Kurt Wüthrich
Impact of protein-protein contacts on the conformation of thrombin-bound hirudin studied by comparison with the nuclear magnetic resonance solution structure of hirudin(1-51).
Journal of molecular biology 1992;228(4):1206-11.
1992: Thomas Szyperski; Peter Güntert; S R Stone; Kurt Wüthrich
Nuclear magnetic resonance solution structure of hirudin(1-51) and comparison with corresponding three-dimensional structures determined using the complete 65-residue hirudin polypeptide chain.
Journal of molecular biology 1992;228(4):1193-205.
1992: Thomas Szyperski; D Neri; B Leiting; Gottfried Otting; Kurt Wüthrich
Support of 1H NMR assignments in proteins by biosynthetically directed fractional 13C-labeling.
Journal of biomolecular NMR 1992;2(4):323-34.
1989: D Neri; Thomas Szyperski; Gottfried Otting; Hans Senn; Kurt Wüthrich
Stereospecific nuclear magnetic resonance assignments of the methyl groups of valine and leucine in the DNA-binding domain of the 434 repressor by biosynthetically directed fractional 13C labeling.
Biochemistry 1989;28(19):7510-6.