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Ira Tabas

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
17
Maxfield, Frederick
13
Kuriakose, George
12
Li, Yankun
11
Williams, Kevin Jon
10
Tall, Alan
10
Beatini, N
8
Schissel, SL
7
Thorp, Edward
7
Yao, Pin Mei
6
Devlin, Cecilia
6
Marathe, Sudhir
5
Han, Seongah
5
Leventhal, Andrew
4
Accili, Domenico
4
Liang, Chien-Ping

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Publications

TOP 3
Thorp Edward; Tabas Ira
Mechanisms and consequences of efferocytosis in advanced atherosclerosis.
Timmins Jenelle M; Ozcan Lale; Seimon Tracie A; Li Gang; Malagelada Cristina; Backs Johannes; Backs Thea; Bassel-Duby Rhonda; Olson Eric N; Anderson Mark E; Tabas Ira
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.
Li Gang; Mongillo Marco; Chin King-Tung; Harding Heather; Ron David; Marks Andrew R; Tabas Ira
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis.

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All Publications

2009: Thorp Edward; Tabas Ira
Mechanisms and consequences of efferocytosis in advanced atherosclerosis.
Journal of leukocyte biology 2009;86(5):1089-95.
2009: Timmins Jenelle M; Ozcan Lale; Seimon Tracie A; Li Gang; Malagelada Cristina; Backs Johannes; Backs Thea; Bassel-Duby Rhonda; Olson Eric N; Anderson Mark E; Tabas Ira
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.
The Journal of clinical investigation 2009;119(10):2925-41.
2009: Li Gang; Mongillo Marco; Chin King-Tung; Harding Heather; Ron David; Marks Andrew R; Tabas Ira
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis.
The Journal of cell biology 2009;186(6):783-92.
2009: Tabas Ira; Seimon Tracie; Timmins Jenelle; Li Gang; Lim Wahseng
Macrophage apoptosis in advanced atherosclerosis.
Annals of the New York Academy of Sciences 2009;1173 Suppl 1():E40-5.
2009: Thorp Edward; Li Gang; Seimon Tracie A; Kuriakose George; Ron David; Tabas Ira
Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.
Cell metabolism 2009;9(5):474-81.
2009: Seimon Tracie; Tabas Ira
Mechanisms and consequences of macrophage apoptosis in atherosclerosis.
Journal of lipid research 2009;50 Suppl():S382-7.
2009: Thorp Edward; Li Yankun; Bao Liping; Yao Pin Mei; Kuriakose George; Rong James; Fisher Edward A; Tabas Ira
Brief report: increased apoptosis in advanced atherosclerotic lesions of Apoe-/- mice lacking macrophage Bcl-2.
Arteriosclerosis, thrombosis, and vascular biology 2009;29(2):169-72.
2008: Li Yankun; Zhang Yuan; Dorweiler Bernhard; Cui Dongying; Wang Tao; Woo Connie W; Brunkan Cynthia S; Wolberger Cynthia; Imai Shin-ichiro; Tabas Ira
Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism.
The Journal of biological chemistry 2008;283(50):34833-43.
2008: Senokuchi Takafumi; Liang Chien-Ping; Seimon Tracie A; Han Seongah; Matsumoto Michihiro; Banks Alexander S; Paik Ji-Hye; DePinho Ronald A; Accili Domenico; Tabas Ira; Tall Alan R
Forkhead transcription factors (FoxOs) promote apoptosis of insulin-resistant macrophages during cholesterol-induced endoplasmic reticulum stress.
Diabetes 2008;57(11):2967-76.
2008: Packard René R S; Maganto-García Elena; Gotsman Israel; Tabas Ira; Libby Peter; Lichtman Andrew H
CD11c(+) dendritic cells maintain antigen processing, presentation capabilities, and CD4(+) T-cell priming efficacy under hypercholesterolemic conditions associated with atherosclerosis.
Circulation research 2008;103(9):965-73.
2008: Devlin Cecilia M; Leventhal Andrew R; Kuriakose George; Schuchman Edward H; Williams Kevin Jon; Tabas Ira
Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(10):1723-30.
2008: Thorp Edward; Cui Dongying; Schrijvers Dorien M; Kuriakose George; Tabas Ira
Mertk receptor mutation reduces efferocytosis efficiency and promotes apoptotic cell accumulation and plaque necrosis in atherosclerotic lesions of apoe-/- mice.
Arteriosclerosis, thrombosis, and vascular biology 2008;28(8):1421-8.
2008: Iqbal Jahangir; Dai Kezhi; Seimon Tracie; Jungreis Rivka; Oyadomari Miho; Kuriakose George; Ron David; Tabas Ira; Hussain M Mahmood
IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA.
Cell metabolism 2008;7(5):445-55.
2008: Lim Wah-Seng; Timmins Jenelle M; Seimon Tracie A; Sadler Anthony; Kolodgie Frank D; Virmani Renu; Tabas Ira
Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo.
Circulation 2008;117(7):940-51.
2007: Tabas Ira
Apoptosis and efferocytosis in mouse models of atherosclerosis.
Current drug targets 2007;8(12):1288-96.
2007: Thorp Edward; Kuriakose George; Shah Yatrik M; Gonzalez Frank J; Tabas Ira
Pioglitazone increases macrophage apoptosis and plaque necrosis in advanced atherosclerotic lesions of nondiabetic low-density lipoprotein receptor-null mice.
Circulation 2007;116(19):2182-90.
2007: Cui Dongying; Thorp Edward; Li Yankun; Wang Nan; Yvan-Charvet Laurent; Tall Alan R; Tabas Ira
Pivotal advance: macrophages become resistant to cholesterol-induced death after phagocytosis of apoptotic cells.
Journal of leukocyte biology 2007;82(5):1040-50.
2007: Tabas Ira; Williams Kevin Jon; Borén Jan
Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications.
Circulation 2007;116(16):1832-44.
2007: Li Yankun; Tabas Ira
The inflammatory cytokine response of cholesterol-enriched macrophages is dampened by stimulated pinocytosis.
Journal of leukocyte biology 2007;81(2):483-91.
2007: Tabas Ira
A two-carbon switch to sterol-induced autophagic death.
Autophagy 2007;3(1):38-41.
2007: Tabas Ira; Seimon Tracie; Arellano Jerry; Li Yankun; Forcheron Fabien; Cui Dongying; Han Seongah; Liang Chien-Ping; Tall Alan; Accili Domenico
The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis.
Novartis Foundation symposium 2007;286():99-109; discussion 109-12, 162-3, 196-203.
2006: Seimon Tracie A; Obstfeld Amrom; Moore Kathryn J; Golenbock Douglas T; Tabas Ira
Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(52):19794-9.
2006: Bao Liping; Li Yankun; Deng Shi-Xian; Landry Donald; Tabas Ira
Sitosterol-containing lipoproteins trigger free sterol-induced caspase-independent death in ACAT-competent macrophages.
The Journal of biological chemistry 2006;281(44):33635-49.
2006: Boullier Agnès; Li Yankun; Quehenberger Oswald; Palinski Wulf; Tabas Ira; Witztum Joseph L; Miller Yury I
Minimally oxidized LDL offsets the apoptotic effects of extensively oxidized LDL and free cholesterol in macrophages.
Arteriosclerosis, thrombosis, and vascular biology 2006;26(5):1169-76.
2006: Han Seongah; Liang Chien-Ping; DeVries-Seimon Tracie; Ranalletta Mollie; Welch Carrie L; Collins-Fletcher Kadesha; Accili Domenico; Tabas Ira; Tall Alan R
Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.
Cell metabolism 2006;3(4):257-66.
2006: Li Yankun; Gerbod-Giannone Marie-Christine; Seitz Heather; Cui Dongying; Thorp Edward; Tall Alan R; Matsushima Glenn K; Tabas Ira
Cholesterol-induced apoptotic macrophages elicit an inflammatory response in phagocytes, which is partially attenuated by the Mer receptor.
The Journal of biological chemistry 2006;281(10):6707-17.
2006: Gerbod-Giannone Marie-Christine; Li Yankun; Holleboom Adriaan; Han Seongah; Hsu Li-Chung; Tabas Ira; Tall Alan R
TNFalpha induces ABCA1 through NF-kappaB in macrophages and in phagocytes ingesting apoptotic cells.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(9):3112-7.
2005: Maxfield Frederick R; Tabas Ira
Role of cholesterol and lipid organization in disease.
Nature 2005;438(7068):612-21.
2005: Tabas Ira
Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(11):2255-64.
2005: Devries-Seimon Tracie; Li Yankun; Yao Pin Mei; Stone Elizabeth; Wang Yibin; Davis Roger J; Flavell Richard; Tabas Ira
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor.
The Journal of cell biology 2005;171(1):61-73.
2005: Jacobs René L; Stead Lori M; Devlin Cecilia; Tabas Ira; Brosnan Margaret E; Brosnan John T; Vance Dennis E
Physiological regulation of phospholipid methylation alters plasma homocysteine in mice.
The Journal of biological chemistry 2005;280(31):28299-305.
2005: Devlin Cecilia M; Lee Sung-Joon; Kuriakose George; Spencer Craig; Becker Lev; Grosskopf Itamar; Ko Carol; Huang Li-Shin; Koschinsky Marlys L; Cooper Allen D; Tabas Ira
An apolipoprotein(a) peptide delays chylomicron remnant clearance and increases plasma remnant lipoproteins and atherosclerosis in vivo.
Arteriosclerosis, thrombosis, and vascular biology 2005;25(8):1704-10.
2005: Li Yankun; Schwabe Robert F; DeVries-Seimon Tracie; Yao Pin Mei; Gerbod-Giannone Marie-Christine; Tall Alan R; Davis Roger J; Flavell Richard; Brenner David A; Tabas Ira
Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis.
The Journal of biological chemistry 2005;280(23):21763-72.
2005: Wüstner Daniel; Mondal Mousumi; Tabas Ira; Maxfield Frederick R
Direct observation of rapid internalization and intracellular transport of sterol by macrophage foam cells.
Traffic (Copenhagen, Denmark) 2005;6(5):396-412.
2005: Mintzer Robert J; Appell Kenneth C; Cole Andrew; Johns Anthony; Pagila Rene; Polokoff Mark A; Tabas Ira; Snider R Michael; Meurer-Ogden Janet A
A novel high-throughput screening format to identify inhibitors of secreted acid sphingomyelinase.
Journal of biomolecular screening : the official journal of the Society for Biomolecular Screening 2005;10(3):225-34.
2004: Jacobs René L; Devlin Cecilia; Tabas Ira; Vance Dennis E
Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase alpha in mice decreases plasma high density and very low density lipoproteins.
The Journal of biological chemistry 2004;279(45):47402-10.
2004: Li Yankun; Ge Mingtao; Ciani Laura; Kuriakose George; Westover Emily J; Dura Miroslav; Covey Douglas F; Freed Jack H; Maxfield Frederick R; Lytton Jonathan; Tabas Ira
Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages.
The Journal of biological chemistry 2004;279(35):37030-9.
2004: Tabas I
Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol.
Cell death and differentiation 2004;11 Suppl 1():S12-6.
2004: Liang Chien-Ping; Han Seongah; Okamoto Haruka; Carnemolla Ronald; Tabas Ira; Accili Domenico; Tall Alan R
Increased CD36 protein as a response to defective insulin signaling in macrophages.
The Journal of clinical investigation 2004;113(5):764-73.
2004: Leventhal Andrew R; Leslie Christina C; Tabas Ira
Suppression of macrophage eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-fatty acyl esterification and the Niemann-Pick C pathway of lipid trafficking.
The Journal of biological chemistry 2004;279(9):8084-92.
2003: Patel Mintoo; Morrow John; Maxfield Frederick R; Strickland Dudley K; Greenberg Steven; Tabas Ira
The cytoplasmic domain of the low density lipoprotein (LDL) receptor-related protein, but not that of the LDL receptor, triggers phagocytosis.
The Journal of biological chemistry 2003;278(45):44799-807.
2003: Feng Bo; Zhang Dajun; Kuriakose George; Devlin Cecillia M; Kockx Mark; Tabas Ira
Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(18):10423-8.
2003: Feng Bo; Yao Pin Mei; Li Yankun; Devlin Cecilia M; Zhang Dajun; Harding Heather P; Sweeney Michele; Rong James X; Kuriakose George; Fisher Edward A; Marks Andrew R; Ron David; Tabas Ira
The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages.
Nature cell biology 2003;5(9):781-92.
2002: Feng Bo; Tabas Ira
ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity.
The Journal of biological chemistry 2002;277(45):43271-80.
2002: Tabas Ira
Consequences of cellular cholesterol accumulation: basic concepts and physiological implications.
The Journal of clinical investigation 2002;110(7):905-11.
2002: Tabas Ira
Cholesterol in health and disease.
The Journal of clinical investigation 2002;110(5):583-90.
2002: Devlin Cecilia M; Kuriakose George; Hirsch Emmet; Tabas Ira
Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(9):6280-5.
2001: Leventhal A R; Chen W; Tall A R; Tabas I
Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux.
The Journal of biological chemistry 2001;276(48):44976-83.
2001: Chen W; Sun Y; Welch C; Gorelik A; Leventhal A R; Tabas I; Tall A R
Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes.
The Journal of biological chemistry 2001;276(47):43564-9.
2001: Yao P M; Tabas I
Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway.
The Journal of biological chemistry 2001;276(45):42468-76.
2001: Sakr S W; Eddy R J; Barth H; Wang F; Greenberg S; Maxfield F R; Tabas I
The uptake and degradation of matrix-bound lipoproteins by macrophages require an intact actin Cytoskeleton, Rho family GTPases, and myosin ATPase activity.
The Journal of biological chemistry 2001;276(40):37649-58.
2000: Marathe S; Choi Y; Leventhal A R; Tabas I
Sphingomyelinase converts lipoproteins from apolipoprotein E knockout mice into potent inducers of macrophage foam cell formation.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(12):2607-13.
2000: Tabas I
Cholesterol and phospholipid metabolism in macrophages.
Biochimica et biophysica acta 2000;1529(1-3):164-74.
2000: Zhang D; Tang W; Yao P M; Yang C; Xie B; Jackowski S; Tabas I
Macrophages deficient in CTP:Phosphocholine cytidylyltransferase-alpha are viable under normal culture conditions but are highly susceptible to free cholesterol-induced death. Molecular genetic evidence that the induction of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response.
The Journal of biological chemistry 2000;275(45):35368-76.
2000: Marathe S; Miranda S R; Devlin C; Johns A; Kuriakose G; Williams K J; Schuchman E H; Tabas I
Creation of a mouse model for non-neurological (type B) Niemann-Pick disease by stable, low level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase: relationship between brain intra-lysosomal enzyme activity and central nervous system function.
Human molecular genetics 2000;9(13):1967-76.
2000: Yao P M; Tabas I
Free cholesterol loading of macrophages induces apoptosis involving the fas pathway.
The Journal of biological chemistry 2000;275(31):23807-13.
2000: Khelef N; Soe T T; Quehenberger O; Beatini N; Tabas I; Maxfield F R
Enrichment of acyl coenzyme A:cholesterol O-acyltransferase near trans-golgi network and endocytic recycling compartment.
Arteriosclerosis, thrombosis, and vascular biology 2000;20(7):1769-76.
2000: Wong M L; Xie B; Beatini N; Phu P; Marathe S; Johns A; Gold P W; Hirsch E; Williams K J; Licinio J; Tabas I
Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(15):8681-6.
1999: Tabas I
Secretory sphingomyelinase.
Chemistry and physics of lipids 1999;102(1-2):123-30.
1999: Marathe S; Kuriakose G; Williams K J; Tabas I
Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(11):2648-58.
1999: Buton X; Mamdouh Z; Ghosh R; Du H; Kuriakose G; Beatini N; Grabowski G A; Maxfield F R; Tabas I
Unique cellular events occurring during the initial interaction of macrophages with matrix-retained or methylated aggregated low density lipoprotein (LDL). Prolonged cell-surface contact during which ldl-cholesteryl ester hydrolysis exceeds ldl protein degradation.
The Journal of biological chemistry 1999;274(45):32112-21.
1999: Bakovic M; Waite K; Tang W; Tabas I; Vance D E
Transcriptional activation of the murine CTP:phosphocholine cytidylyltransferase gene (Ctpct): combined action of upstream stimulatory and inhibitory cis-acting elements.
Biochimica et biophysica acta 1999;1438(1):147-65.
1999: Tang W; Walsh A; Tabas I
Macrophage-targeted CTP:phosphocholine cytidylyltransferase (1-314) transgenic mice.
Biochimica et biophysica acta 1999;1437(3):301-16.
1998: Mukherjee S; Zha X; Tabas I; Maxfield F R
Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog.
Biophysical journal 1998;75(4):1915-25.
1998: Schissel S L; Keesler G A; Schuchman E H; Williams K J; Tabas I
The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene.
The Journal of biological chemistry 1998;273(29):18250-9.
1998: Khelef N; Buton X; Beatini N; Wang H; Meiner V; Chang T Y; Farese R V; Maxfield F R; Tabas I
Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages.
The Journal of biological chemistry 1998;273(18):11218-24.
1998: Jeong Ts; Schissel S L; Tabas I; Pownall H J; Tall A R; Jiang X
Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase.
The Journal of clinical investigation 1998;101(4):905-12.
1998: Marathe S; Schissel S L; Yellin M J; Beatini N; Mintzer R; Williams K J; Tabas I
Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell signaling.
The Journal of biological chemistry 1998;273(7):4081-8.
1998: Schissel S L; Jiang X; Tweedie-Hardman J; Jeong T; Camejo E H; Najib J; Rapp J H; Williams K J; Tabas I
Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development.
The Journal of biological chemistry 1998;273(5):2738-46.
1998: Zha X; Pierini L M; Leopold P L; Skiba P J; Tabas I; Maxfield F R
Sphingomyelinase treatment induces ATP-independent endocytosis.
The Journal of cell biology 1998;140(1):39-47.
1997: Tabas I
Phospholipid metabolism in cholesterol-loaded macrophages.
Current opinion in lipidology 1997;8(5):263-7.
1997: Zha X; Tabas I; Leopold P L; Jones N L; Maxfield F R
Evidence for prolonged cell-surface contact of acetyl-LDL before entry into macrophages.
Arteriosclerosis, thrombosis, and vascular biology 1997;17(7):1421-31.
1997: Tang W; Keesler G A; Tabas I
The structure of the gene for murine CTP:phosphocholine cytidylyltransferase, Ctpct. Relationship of exon structure to functional domains and identification of transcriptional start sites and potential upstream regulatory elements.
The Journal of biological chemistry 1997;272(20):13146-51.
1996: Keesler G A; Gabel B R; Devlin C M; Koschinsky M L; Tabas I
The binding activity of the macrophage lipoprotein(a)/apolipoprotein(a) receptor is induced by cholesterol via a post-translational mechanism and recognizes distinct kringle domains on apolipoprotein(a).
The Journal of biological chemistry 1996;271(50):32096-104.
1996: Schissel S L; Tweedie-Hardman J; Rapp J H; Graham G; Williams K J; Tabas I
Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins.
The Journal of clinical investigation 1996;98(6):1455-64.
1996: Tabas I; Marathe S; Keesler G A; Beatini N; Shiratori Y
Evidence that the initial up-regulation of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response that prevents cholesterol-induced cellular necrosis. Proposed role of an eventual failure of this response in foam cell necrosis in advanced atherosclerosis.
The Journal of biological chemistry 1996;271(37):22773-81.
1996: Schissel S L; Schuchman E H; Williams K J; Tabas I
Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene.
The Journal of biological chemistry 1996;271(31):18431-6.
1996: Skiba P J; Zha X; Maxfield F R; Schissel S L; Tabas I
The distal pathway of lipoprotein-induced cholesterol esterification, but not sphingomyelinase-induced cholesterol esterification, is energy-dependent.
The Journal of biological chemistry 1996;271(23):13392-400.
1996: Wang N; Tabas I; Winchester R; Ravalli S; Rabbani L E; Tall A
Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma.
The Journal of biological chemistry 1996;271(15):8837-42.
1995: Shiratori Y; Houweling M; Zha X; Tabas I
Stimulation of CTP:phosphocholine cytidylyltransferase by free cholesterol loading of macrophages involves signaling through protein dephosphorylation.
The Journal of biological chemistry 1995;270(50):29894-903.
1995: Tabas I
The stimulation of the cholesterol esterification pathway by atherogenic lipoproteins in macrophages.
Current opinion in lipidology 1995;6(5):260-8.
1995: Schissel S L; Beatini N; Zha X; Maxfield F R; Tabas I
Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and Chinese hamster ovary cells.
Biochemistry 1995;34(33):10463-73.
1994: Granot E; Schwiegelshohn B; Tabas I; Gorecki M; Vogel T; Carpentier Y A; Deckelbaum R J
Effects of particle size on cell uptake of model triglyceride-rich particles with and without apoprotein E.
Biochemistry 1994;33(50):15190-7.
1994: Tabas I
Atherosclerosis: cell biology and lipoproteins.
Current opinion in lipidology 1994;5(5):U126-31.
1994: Skiba P J; Keesler G A; Tabas I
Interferon-gamma down-regulates the lipoprotein(a)/apoprotein(a) receptor activity on macrophage foam cells. Evidence for disruption of ligand-induced receptor recycling by interferon-gamma.
The Journal of biological chemistry 1994;269(37):23059-67.
1994: Tabas I; Zha X; Beatini N; Myers J N; Maxfield F R
The actin cytoskeleton is important for the stimulation of cholesterol esterification by atherogenic lipoproteins in macrophages.
The Journal of biological chemistry 1994;269(36):22547-56.
1994: Keesler G A; Li Y; Skiba P J; Fless G M; Tabas I
Macrophage foam cell lipoprotein(a)/apoprotein(a) receptor. Cell-surface localization, dependence of induction on new protein synthesis, and ligand specificity.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1994;14(8):1337-45.
1994: Shiratori Y; Okwu A K; Tabas I
Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP: phosphocholine cytidylyltransferase.
The Journal of biological chemistry 1994;269(15):11337-48.
1994: Okwu A K; Xu X X; Shiratori Y; Tabas I
Regulation of the threshold for lipoprotein-induced acyl-CoA:cholesterol O-acyltransferase stimulation in macrophages by cellular sphingomyelin content.
Journal of lipid research 1994;35(4):644-55.
1993: Myers J N; Tabas I; Jones N L; Maxfield F R
Beta-very low density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages.
The Journal of cell biology 1993;123(6 Pt 1):1389-402.
1993: Tabas I; Li Y; Brocia R W; Xu S W; Swenson T L; Williams K J
Lipoprotein lipase and sphingomyelinase synergistically enhance the association of atherogenic lipoproteins with smooth muscle cells and extracellular matrix. A possible mechanism for low density lipoprotein and lipoprotein(a) retention and macrophage foam cell formation.
The Journal of biological chemistry 1993;268(27):20419-32.
1993: Bottalico L A; Keesler G A; Fless G M; Tabas I
Cholesterol loading of macrophages leads to marked enhancement of native lipoprotein(a) and apoprotein(a) internalization and degradation.
The Journal of biological chemistry 1993;268(12):8569-73.
1993: Bottalico L A; Kendrick N C; Keller A; Li Y; Tabas I
Cholesteryl ester loading of mouse peritoneal macrophages is associated with changes in the expression or modification of specific cellular proteins, including increase in an alpha-enolase isoform.
Arteriosclerosis and thrombosis : a journal of vascular biology / American Heart Association 1993;13(2):264-75.
1991: Xu X X; Tabas I
Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages.
The Journal of biological chemistry 1991;266(36):24849-58.
1991: Bottalico L A; Wager R E; Agellon L B; Assoian R K; Tabas I
Transforming growth factor-beta 1 inhibits scavenger receptor activity in THP-1 human macrophages.
The Journal of biological chemistry 1991;266(34):22866-71.
1991: Tabas I; Myers J N; Innerarity T L; Xu X X; Arnold K; Boyles J; Maxfield F R
The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of beta-VLDL in mouse peritoneal macrophages.
The Journal of cell biology 1991;115(6):1547-60.
1991: Tabas I; Beatini N; Chen L L; Su W C; Puar M S; Dugar S; Clader J W
Identification and characterization of an acyl-CoA:triterpene acyltransferase activity in rabbit and human tissues.
Journal of lipid research 1991;32(10):1689-98.
1991: Xu X X; Tabas I
Lipoproteins activate acyl-coenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level.
The Journal of biological chemistry 1991;266(26):17040-8.
1990: Tabas I; Lim S; Xu X X; Maxfield F R
Endocytosed beta-VLDL and LDL are delivered to different intracellular vesicles in mouse peritoneal macrophages.
The Journal of cell biology 1990;111(3):929-40.
1990: Tabas I; Chen L L; Clader J W; McPhail A T; Burnett D A; Bartner P; Das P R; Pramanik B N; Puar M S; Feinmark S J
Rabbit and human liver contain a novel pentacyclic triterpene ester with acyl-CoA: cholesterol acyltransferase inhibitory activity.
The Journal of biological chemistry 1990;265(14):8042-51.
1989: Tabas I; Feinmark S J; Beatini N
The reactivity of desmosterol and other shellfish- and xanthomatosis-associated sterols in the macrophage sterol esterification reaction.
The Journal of clinical investigation 1989;84(6):1713-21.
1989: Khoo J C; Miller E; McLoughlin P; Tabas I; Rosoff W J
Cholesterol esterification as a limiting factor in accumulation of cell cholesterol: a comparison of two J774 macrophage cell lines.
Biochimica et biophysica acta 1989;1012(2):215-7.
1988: Tabas I; Rosoff W J; Boykow G C
Acyl coenzyme A:cholesterol acyl transferase in macrophages utilizes a cellular pool of cholesterol oxidase-accessible cholesterol as substrate.
The Journal of biological chemistry 1988;263(3):1266-72.
1987: Tabas I; Boykow G C
Protein synthesis inhibition in mouse peritoneal macrophages results in increased acyl coenzyme A:cholesterol acyl transferase activity and cholesteryl ester accumulation in the presence of native low density lipoprotein.
The Journal of biological chemistry 1987;262(25):12175-81.
1987: Tall A; Granot E; Brocia R; Tabas I; Hesler C; Williams K; Denke M
Accelerated transfer of cholesteryl esters in dyslipidemic plasma. Role of cholesteryl ester transfer protein.
The Journal of clinical investigation 1987;79(4):1217-25.
1987: Tabas I; Boykow G C; Tall A R
Foam cell-forming J774 macrophages have markedly elevated acyl coenzyme A:cholesterol acyl transferase activity compared with mouse peritoneal macrophages in the presence of low density lipoprotein (LDL) despite similar LDL receptor activity.
The Journal of clinical investigation 1987;79(2):418-26.

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