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Tetsuya Taga

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Chemicals & Drugs

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Keisuke Hagihara; Teppei Nishikawa; Yasuhiro Sugamata; Jian Song; Tomoyasu Isobe; Tetsuya Taga; Kazuyuki Yoshizaki
Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression.
X J Wang; Tetsuya Taga; Kanji Yoshida; M Saito; Tadamitsu Kishimoto; Hitoshi Kikutani
gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6.
Tetsuji Naka; Michiko Narazaki; M Hirata; Takuya Matsumoto; S Minamoto; A Aono; N Nishimoto; T Kajita; Tetsuya Taga; Kazuyuki Yoshizaki; S Akira; Tadamitsu Kishimoto
Structure and function of a new STAT-induced STAT inhibitor.

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2005: Keisuke Hagihara; Teppei Nishikawa; Yasuhiro Sugamata; Jian Song; Tomoyasu Isobe; Tetsuya Taga; Kazuyuki Yoshizaki
Essential role of STAT3 in cytokine-driven NF-kappaB-mediated serum amyloid A gene expression.
Genes to cells : devoted to molecular & cellular mechanisms 2005;10(11):1051-63.
1998: X J Wang; Tetsuya Taga; Kanji Yoshida; M Saito; Tadamitsu Kishimoto; Hitoshi Kikutani
gp130, the cytokine common signal-transducer of interleukin-6 cytokine family, is downregulated in T cells in vivo by interleukin-6.
Blood 1998;91(9):3308-14.
1997: Tetsuji Naka; Michiko Narazaki; M Hirata; Takuya Matsumoto; S Minamoto; A Aono; N Nishimoto; T Kajita; Tetsuya Taga; Kazuyuki Yoshizaki; S Akira; Tadamitsu Kishimoto
Structure and function of a new STAT-induced STAT inhibitor.
Nature 1997;387(6636):924-9.
1997: K Nakashima; Michiko Narazaki; Tetsuya Taga
Leptin receptor (OB-R) oligomerizes with itself but not with its closely related cytokine signal transducer gp130.
FEBS letters 1997;403(1):79-82.
1997: I S Lee; Y Liu; Michiko Narazaki; Masahiko Hibi; Tadamitsu Kishimoto; Tetsuya Taga
Vav is associated with signal transducing molecules gp130, Grb2 and Erk2, and is tyrosine phosphorylated in response to interleukin-6.
FEBS letters 1997;401(2-3):133-7.
1997: K Nakashima; Michiko Narazaki; Tetsuya Taga
Overlapping and distinct signals through leptin receptor (OB-R) and a closely related cytokine signal transducer, gp130.
FEBS letters 1997;401(1):49-52.
1997: Tetsuya Taga; Tadamitsu Kishimoto
Gp130 and the interleukin-6 family of cytokines.
Annual review of immunology 1997;15():797-819.
1996: Keiko Yamauchi-Takihara; Hisao Hirota; Keita Kunisada; H Matsui; Yasushi Fujio; Tetsuya Taga; Tadamitsu Kishimoto
Roles of gp130 signaling pathways in cardiac myocytes: recent advances and implications for cardiovascular disease.
Journal of cardiac failure 1996;2(4 Suppl):S63-8.
1996: D Watanabe; R Yoshimura; M Khalil; Kanji Yoshida; Tadamitsu Kishimoto; Tetsuya Taga; Hiroshi Kiyama
Characteristic localization of gp130 (the signal-transducing receptor component used in common for IL-6/IL-11/CNTF/LIF/OSM) in the rat brain.
The European journal of neuroscience 1996;8(8):1630-40.
1996: Jennifer Nichols; D Davidson; Tetsuya Taga; Kanji Yoshida; Ian Chambers; Austin Smith
Complementary tissue-specific expression of LIF and LIF-receptor mRNAs in early mouse embryogenesis.
Mechanisms of development 1996;57(2):123-31.
1996: Tetsuya Taga
Gp130, a shared signal transducing receptor component for hematopoietic and neuropoietic cytokines.
Journal of neurochemistry 1996;67(1):1-10.
1996: Hisao Hirota; Hiroshi Kiyama; Tadamitsu Kishimoto; Tetsuya Taga
Accelerated Nerve Regeneration in Mice by upregulated expression of interleukin (IL) 6 and IL-6 receptor after trauma.
The Journal of experimental medicine 1996;183(6):2627-34.
1996: Hirohiko Shibayama; S Tagawa; H Hattori; Kenichi Harigaya; Tetsuya Taga; Takashi Machii; Teruo Kitani
Interleukin-6 inhibits the chemotaxis of human malignant plasma cell lines.
British journal of haematology 1996;93(3):534-41.
1996: Hisao Hirota; Kanji Yoshida; Tetsuya Taga; Tadamitsu Kishimoto
gp130 signaling pathways: Recent advances and implications for cardiovascular disease.
Trends in cardiovascular medicine 1996;6(4):109-15.
1996: Kanji Yoshida; Tetsuya Taga; M Saito; Sachiko Suematsu; A Kumanogoh; T Tanaka; Hiromi Fujiwara; M Hirata; T Yamagami; T Nakahata; T Hirabayashi; Yoshihiro Yoneda; K Tanaka; W Z Wang; C Mori; K Shiota; N Yoshida; Tadamitsu Kishimoto
Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(1):407-11.
1995: S Akira; Kanji Yoshida; T Tanaka; Tetsuya Taga; Tadamitsu Kishimoto
Targeted disruption of the IL-6 related genes: gp130 and NF-IL-6.
Immunological reviews 1995;148():221-53.
1995: Tadamitsu Kishimoto; T Tanaka; Kanji Yoshida; S Akira; Tetsuya Taga
Cytokine signal transduction through a homo- or heterodimer of gp130.
Annals of the New York Academy of Sciences 1995;766():224-34.
1995: Tadamitsu Kishimoto; S Akira; Michiko Narazaki; Tetsuya Taga
Interleukin-6 family of cytokines and gp130.
Blood 1995;86(4):1243-54.
1995: Masaaki Yamaguchi; Tetsuya Taga; Tadamitsu Kishimoto; A Miyake
Cytokines that use gp130 as a signal transducer stimulate mouse placental lactogen-I (mPL-I) but inhibit mPL-II production in vitro.
Biology of reproduction 1995;53(2):399-406.
1995: Masaaki Yamaguchi; A Mammoto; Tetsuya Taga; Tadamitsu Kishimoto; A Miyake
Regulation of mouse soluble interleukin-6 receptor secretion by decidua.
Biochemical and biophysical research communications 1995;211(3):1077-82.
1995: Hisao Hirota; Kanji Yoshida; Tadamitsu Kishimoto; Tetsuya Taga
Continuous activation of gp130, a signal-transducing receptor component for interleukin 6-related cytokines, causes myocardial hypertrophy in mice.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(11):4862-6.
1995: K Sawai; Nobue Matsuzaki; T Kameda; K Hashimoto; T Okada; Koichiro Shimoya; Toshikatsu Nobunaga; Tetsuya Taga; Tadamitsu Kishimoto; Fumitaka Saji
Leukemia inhibitory factor produced at the fetomaternal interface stimulates chorionic gonadotropin production: its possible implication during pregnancy, including implantation period.
The Journal of clinical endocrinology and metabolism 1995;80(4):1449-56.
1995: Masaaki Yamaguchi; Naomasa Miki; M Ono; C Ohtsuka; H Demura; Hirohisa Kurachi; M Inoue; H Endo; Tetsuya Taga; Tadamitsu Kishimoto
Inhibition of growth hormone-releasing factor production in mouse placenta by cytokines using gp130 as a signal transducer.
Endocrinology 1995;136(3):1072-8.
1995: Tetsuya Taga; Tadamitsu Kishimoto
Signaling mechanisms through cytokine receptors that share signal transducing receptor components.
Current opinion in immunology 1995;7(1):17-23.
1994: Takashi Maeda; Masaaki Yamaguchi; Tetsuya Taga; Tadamitsu Kishimoto; K Wada; Hiroshi Ikegami; Hirohisa Kurachi; A Miyake
Decidua is a possible source of serum mouse soluble interleukin-6 receptor (msIL-6R): gestational profile of serum msIL-6R concentration.
Biochemical and biophysical research communications 1994;205(2):998-1003.
1994: Michiko Narazaki; bruce witthuhn; Kanji Yoshida; O Silvennoinen; K Yasukawa; James N Ihle; Tadamitsu Kishimoto; Tetsuya Taga
Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(6):2285-9.
1994: Kanji Yoshida; Ian Chambers; Jennifer Nichols; Austin Smith; M Saito; K Yasukawa; M Shoyab; Tetsuya Taga; Tadamitsu Kishimoto
Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways.
Mechanisms of development 1994;45(2):163-71.
1994: Tadamitsu Kishimoto; Tetsuya Taga; S Akira
Cytokine signal transduction.
Cell 1994;76(2):253-62.
1993: Michiko Narazaki; K Yasukawa; T Saito; Yoshiyuki Ohsugi; H Fukui; Y Koishihara; G D Yancopoulos; Tetsuya Taga; Tadamitsu Kishimoto
Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130.
Blood 1993;82(4):1120-6.
1993: T Saito; Tetsuya Taga; D Miki; K Futatsugi; H Yawata; Tadamitsu Kishimoto; K Yasukawa
Preparation of monoclonal antibodies against the IL-6 signal transducer, gp130, that can inhibit IL-6-mediated functions.
Journal of immunological methods 1993;163(2):217-23.
1993: M Murakami; Masahiko Hibi; N Nakagawa; T Nakagawa; K Yasukawa; K Yamanishi; Tetsuya Taga; Tadamitsu Kishimoto
IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase.
Science (New York, N.Y.) 1993;260(5115):1808-10.
1993: H Suzuki; K Yasukawa; T Saito; Michiko Narazaki; A Hasegawa; Tetsuya Taga; Tadamitsu Kishimoto
Serum soluble interleukin-6 receptor in MRL/lpr mice is elevated with age and mediates the interleukin-6 signal.
European journal of immunology 1993;23(5):1078-82.
1993: Neil stahl; S Davis; V Wong; Tetsuya Taga; Tadamitsu Kishimoto; N Y Ip; George D Yancopoulos
Cross-linking identifies leukemia inhibitory factor-binding protein as a ciliary neurotrophic factor receptor component.
The Journal of biological chemistry 1993;268(11):7628-31.
1993: H Yawata; K Yasukawa; Shunji Natsuka; M Murakami; K Yamasaki; Masahiko Hibi; Tetsuya Taga; Tadamitsu Kishimoto
Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130.
The EMBO journal 1993;12(4):1705-12.
1993: S Akira; Tetsuya Taga; Tadamitsu Kishimoto
Interleukin-6 in biology and medicine.
Advances in immunology 1993;54():1-78.
1992: I Kobayashi; Toshio Matsuda; T Saito; K Yasukawa; Hitoshi Kikutani; Toshio Hirano; Tetsuya Taga; Tadamitsu Kishimoto
Abnormal distribution of IL-6 receptor in aged MRL/lpr mice: elevated expression on B cells and absence on CD4+ cells.
International immunology 1992;4(12):1407-12.
1992: Tetsuya Taga; Michiko Narazaki; K Yasukawa; T Saito; D Miki; M Hamaguchi; S Davis; M Shoyab; G D Yancopoulos; Tadamitsu Kishimoto
Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(22):10998-1001.
1992: Tadamitsu Kishimoto; S Akira; Tetsuya Taga
Interleukin-6 and its receptor: a paradigm for cytokines.
Science (New York, N.Y.) 1992;258(5082):593-7.
1992: Tetsuya Taga
IL6 signalling through IL6 receptor and receptor-associated signal transducer, gp130.
Research in immunology 1992;143(7):737-9.
1992: H Suzuki; K Yasukawa; T Saito; R Goitsuka; A Hasegawa; Y Ohsugi; Tetsuya Taga; Tadamitsu Kishimoto
Anti-human interleukin-6 receptor antibody inhibits human myeloma growth in vivo.
European journal of immunology 1992;22(8):1989-93.
1992: Tetsuya Taga
[The interleukin-6 signal transducer, gp130, functioning in immune, hematopoietic, and neural systems].
Nihon rinsho. Japanese journal of clinical medicine 1992;50(8):1802-10.
1992: M Saito; Kanji Yoshida; Masahiko Hibi; Tetsuya Taga; Tadamitsu Kishimoto
Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo.
Journal of immunology (Baltimore, Md. : 1950) 1992;148(12):4066-71.
1992: Tadatsugu Taniguchi; Nobue Matsuzaki; T Jo; Fumitaka Saji; Tetsuya Taga; Toshio Hirano; Tadamitsu Kishimoto; O Tanizawa
Interleukin-1 (IL-1)-induced IL-6- and IL-6-receptor-mediated release of human chorionic gonadotropin by choriocarcinoma cell lines (Jar and HCCM-5) activates adenosine 3',5'-monophosphate-independent signal transduction pathway.
The Journal of clinical endocrinology and metabolism 1992;74(6):1389-95.
1992: Tadamitsu Kishimoto; S Akira; Tetsuya Taga
IL-6 receptor and mechanism of signal transduction.
International journal of immunopharmacology 1992;14(3):431-8.
1992: K Yasukawa; K Futatsugi; T Saito; H Yawata; Michiko Narazaki; H Suzuki; Tetsuya Taga; Tadamitsu Kishimoto
Association of recombinant soluble IL-6-signal transducer, gp130, with a complex of IL 6 and soluble IL-6 receptor, and establishment of an ELISA for soluble gp130.
Immunology letters 1992;31(2):123-30.
1992: Tetsuya Taga; Tadamitsu Kishimoto
Role of a two-chain IL-6 receptor system in immune and hematopoietic cell regulation.
Critical reviews in immunology 1992;11(5):265-80.
1992: Tetsuya Taga; Masahiko Hibi; M Murakami; M Saito; H Yawata; Michiko Narazaki; Y Hirata; T Sugita; K Yasukawa; Toshio Hirano
Interleukin-6 receptor and signals.
Chemical immunology 1992;51():181-204.
1992: Tadamitsu Kishimoto; Masahiko Hibi; M Murakami; Michiko Narazaki; M Saito; Tetsuya Taga
The molecular biology of interleukin 6 and its receptor.
Ciba Foundation symposium 1992;167():5-16; discussion 16-23.
1991: M Murakami; Michiko Narazaki; Masahiko Hibi; H Yawata; K Yasukawa; M Hamaguchi; Tetsuya Taga; Tadamitsu Kishimoto
Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11349-53.
1991: H Suzuki; K Yasukawa; T Saito; M Anzai; R Goitsuka; A Hasegawa; Y Ohsugi; Tetsuya Taga; Tadamitsu Kishimoto
Anti-murine IL-6 receptor antibody inhibits IL-6 effects in vivo.
Immunology letters 1991;30(1):17-21.
1990: Masahiko Hibi; M Murakami; M Saito; Toshio Hirano; Tetsuya Taga; Tadamitsu Kishimoto
Molecular cloning and expression of an IL-6 signal transducer, gp130.
Cell 1990;63(6):1149-57.
1990: Toshio Hirano; S Akira; Tetsuya Taga; Tadamitsu Kishimoto
Biological and clinical aspects of interleukin 6.
Immunology today 1990;11(12):443-9.
1990: Kazuyuki Yoshizaki; Norihiro Nishimoto; K Matsumoto; H Tagoh; Tetsuya Taga; Y Deguchi; T Kuritani; Toshio Hirano; K Hashimoto; N Okada
Interleukin 6 and expression of its receptor on epidermal keratinocytes.
Cytokine 1990;2(5):381-7.
1990: T Sugita; T Totsuka; M Saito; K Yamasaki; Tetsuya Taga; Toshio Hirano; Tadamitsu Kishimoto
Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis.
The Journal of experimental medicine 1990;171(6):2001-9.
1990: Toshio Hirano; Tetsuya Taga; Toshio Matsuda; Masahiko Hibi; Sachiko Suematsu; B Tang; M Murakami; Tadamitsu Kishimoto
Interleukin 6 and its receptor in the immune response and hematopoiesis.
International journal of cell cloning 1990;8 Suppl 1():155-66; discussion 166-7.
1990: Sachiko Suematsu; Masahiko Hibi; T Sugita; M Saito; M Murakami; T Matsusaka; Toshio Matsuda; Toshio Hirano; Tetsuya Taga; Tadamitsu Kishimoto
Interleukin 6 (IL-6) and its receptor (IL-6R) in myeloma/plasmacytoma.
Current topics in microbiology and immunology 1990;166():13-22.
1989: Y Hirata; Tetsuya Taga; Masahiko Hibi; N Nakano; Toshio Hirano; Tadamitsu Kishimoto
Characterization of IL-6 receptor expression by monoclonal and polyclonal antibodies.
Journal of immunology (Baltimore, Md. : 1950) 1989;143(9):2900-6.
1989: Tetsuya Taga; Masahiko Hibi; Y Hirata; K Yamasaki; K Yasukawa; Toshio Matsuda; Toshio Hirano; Tadamitsu Kishimoto
Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130.
Cell 1989;58(3):573-81.
1989: Toshio Matsuda; K Yamasaki; Tetsuya Taga; Toshio Hirano; Tadamitsu Kishimoto
Current concepts of B cell modulation.
International reviews of immunology 1989;5(2):97-109.
1989: Toshio Hirano; Tetsuya Taga; K Yamasaki; Toshio Matsuda; K Yasukawa; Y Hirata; H Yawata; O Tanabe; S Akira; Tadamitsu Kishimoto
Molecular cloning of the cDNAs for interleukin-6/B cell stimulatory factor 2 and its receptor.
Annals of the New York Academy of Sciences 1989;557():167-78, discussion 178-80.
1989: Tadamitsu Kishimoto; Tetsuya Taga; K Yamasaki; Toshio Matsuda; B Tang; Atsushi Muraguchi; Y Horii; Sachiko Suematsu; Y Hirata; H Yawata
Normal and abnormal regulation of human B cell differentiation by a new cytokine, BSF2/IL-6.
Advances in experimental medicine and biology 1989;254():135-43.
1989: Toshio Hirano; Tetsuya Taga; K Yamasaki; Toshio Matsuda; B Tang; Atsushi Muraguchi; Y Horii; Sachiko Suematsu; Y Hirata; H Yawata
A multifunctional cytokine (IL-6/BSF-2) and its receptor.
International archives of allergy and applied immunology 1989;88(1-2):29-33.
1989: Tetsuya Taga; Masahiko Hibi; Y Hirata; H Yawata; Shunji Natsuka; K Yasukawa; T Totsuka; K Yamasaki; Toshio Hirano; Tadamitsu Kishimoto
Interleukin-6 receptor and a unique mechanism of its signal transduction.
Cold Spring Harbor symposia on quantitative biology 1989;54 Pt 2():713-22.
1988: K Yamasaki; Tetsuya Taga; Y Hirata; H Yawata; Y Kawanishi; B Seed; Tadatsugu Taniguchi; Toshio Hirano; Tadamitsu Kishimoto
Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor.
Science (New York, N.Y.) 1988;241(4867):825-8.
1988: T Hirano; Tetsuya Taga; T Matsuda; Y Horii; B Tang; Y Kawanishi; Sachiko Suematsu; T Kishimoto
[Cytokines and receptors--their functions, structures and cloning of code genes. Functional polymorphism of BSF-2/IL-6 and its abnormal expression].
Nihon rinsho. Japanese journal of clinical medicine 1988;46(5):1029-35.
1987: Tetsuya Taga; Y Kawanishi; R R Hardy; Toshio Hirano; Tadamitsu Kishimoto
Receptors for B cell stimulatory factor 2. Quantitation, specificity, distribution, and regulation of their expression.
The Journal of experimental medicine 1987;166(4):967-81.