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Tom Taghon

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Jessica Filtjens; Tessa C C Kerre; Jean Plum; Tom Taghon; Sylvie Taveirne; Aline Van Acker; Els Van Ammel; Bart Vandekerckhove; Mandy Vanhees; Georges Leclercq
Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function.
Inge Van de Walle; Bart Vandekerckhove; Els Waegemans; Tao Wang; Jelle De Medts; Magda De Smedt; Greet De Smet; Thomas Gridley; Tessa Kerre; Ute Koch; Georges Leclercq; Jean Plum; Freddy Radtke; Sylvia Snauwaert; Tom Taghon
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.
Tina Van Den Broeck; Bart Vandekerckhove; Maarten Delforche; Tessa C C Kerre; Jean Plum; Tom Taghon; Sylvie Taveirne; Els Van Ammel; Georges Leclercq
Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells.

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All Publications

2013: Jessica Filtjens; Tessa C C Kerre; Jean Plum; Tom Taghon; Sylvie Taveirne; Aline Van Acker; Els Van Ammel; Bart Vandekerckhove; Mandy Vanhees; Georges Leclercq
Abundant stage-dependent Ly49E expression by liver NK cells is not essential for their differentiation and function.
Journal of leukocyte biology 2013;93(5):699-711.
2013: Inge Van de Walle; Bart Vandekerckhove; Els Waegemans; Tao Wang; Jelle De Medts; Magda De Smedt; Greet De Smet; Thomas Gridley; Tessa Kerre; Ute Koch; Georges Leclercq; Jean Plum; Freddy Radtke; Sylvia Snauwaert; Tom Taghon
Specific Notch receptor-ligand interactions control human TCR-αβ/γδ development by inducing differential Notch signal strength.
The Journal of experimental medicine 2013;210(4):683-97.
2013: Tina Van Den Broeck; Bart Vandekerckhove; Maarten Delforche; Tessa C C Kerre; Jean Plum; Tom Taghon; Sylvie Taveirne; Els Van Ammel; Georges Leclercq
Differential Ly49e expression pathways in resting versus TCR-activated intraepithelial γδ T cells.
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):1982-90.
2012: Sylvia Snauwaert; Tom Taghon; Kris Thielemans; Yasmine Van Caeneghem; Zwi N Berneman; Glenn Goetgeluk; Tessa C C Kerre; Georges Leclercq; Jan Philippé; Jean Plum; Stijn Vanhee; Imke Velghe; Greet Verstichel; Bart Vandekerckhove
RHAMM/HMMR (CD168) is not an ideal target antigen for immunotherapy of acute myeloid leukemia.
Haematologica 2012;97(10):1539-47.
2012: Jolien Vermeire; Veronica Iannucci; Alessia Landi; Evelien Naessens; Massimo Pizzato; Tom Taghon; Anouk Van Nuffel; Hanne Vanderstraeten; Bruno Verhasselt
Quantification of reverse transcriptase activity by real-time PCR as a fast and accurate method for titration of HIV, lenti- and retroviral vectors.
PloS one 2012;7(12):e50859.
2012: Tom Taghon; Els Waegemans; Inge Van de Walle
Notch signaling during human T cell development.
Current topics in microbiology and immunology 2012;360():75-97.
2011: Veerle De Colvenaer; Magda De Smedt; Maarten Delforche; Jean Plum; Tom Taghon; Sylvie Taveirne; Bart Vandekerckhove; Louis Boon; Georges Leclercq
CD27-deficient mice show normal NK-cell differentiation but impaired function upon stimulation.
Immunology and cell biology 2011;89(7):803-11.
2011: An De Weer; Marta Jeison; Torsten A Konrad; Frédéric Lambert; Pieter Mestdagh; Lucien Noens; Maria Odero; Jan Philippé; Hélène-Antoine Poirel; Bruce Poppe; Pieter Rondou; Maria García Sánchez; Tom Taghon; Joni Van der Meulen; Tom Van Maerken; Nadine Van Roy; Pieter Van Vlierberghe; Peter Vandenberghe; Jo Vandesompele; Bruno Verhasselt; Rotraud Wieser; Isaac Yaniv; Barbara Cauwelier; Nicole Dastugue; Anne De Paepe; Katleen De Preter; Frank Speleman
EVI1-mediated down regulation of MIR449A is essential for the survival of EVI1 positive leukaemic cells.
British journal of haematology 2011;154(3):337-48.
2011: Konstantinos J Mavrakis; Evelien Mets; Pieter Rondou; Nicholas B Socci; Frank Speleman; Tom Taghon; Joni Van Der Meulen; Pieter Van Vlierberghe; Peter Vandenberghe; Yves Benoit; Eric Delabesse; Aly A Khan; Christina S Leslie; Xiaoping Liu; Andrew L Wolfe; Manu Setty; Manu Setti; Hans-Guido Wendel
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).
Nature genetics 2011;43(7):673-8.
2011: Sylvie Taveirne; Els Van Ammel; Tina Van Den Broeck; Bart Vandekerckhove; Clare L Bennett; Björn E Clausen; Veerle De Colvenaer; Daniel H Kaplan; Jean Plum; Tom Taghon; Georges Leclercq
Langerhans cells are not required for epidermal Vgamma3 T cell homeostasis and function.
Journal of leukocyte biology 2011;90(1):61-8.
2011: Apostolos Klinakis; Camille Lobry; Omar Abdel-Wahab; Philmo Oh; Hiroshi Haeno; Silvia Buonamici; Inge van De Walle; Severine Cathelin; Thomas Trimarchi; Elisa Araldi; Cynthia Liu; Sherif Ibrahim; Miroslav Beran; Jiri Zavadil; Argiris Efstratiadis; Tom Taghon; Franziska Michor; Ross L Levine; Iannis Aifantis
A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia.
Nature 2011;473(7346):230-3.
2011: Magda De Smedt; Georges Leclercq; Bart Vandekerckhove; Tessa Kerre; Tom Taghon; Jean Plum
T-lymphoid differentiation potential measured in vitro is higher in CD34+CD38-/lo hematopoietic stem cells from umbilical cord blood than from bone marrow and is an intrinsic property of the cells.
Haematologica 2011;96(5):646-54.
2011: Inge Van de Walle; Greet De Smet; Martina Gärtner; Magda De Smedt; Els Waegemans; Bart Vandekerckhove; Georges Leclercq; Jean Plum; Jon C Aster; Irwin D Bernstein; Cynthia J Guidos; Bruno Kyewski; Tom Taghon
Jagged2 acts as a Delta-like Notch ligand during early hematopoietic cell fate decisions.
Blood 2011;117(17):4449-59.
2011: Bart Vandekerckhove; Stijn Vanhee; Stefanie Van Coppernolle; Sylvia Snauwaert; Imke Velghe; Tom Taghon; Georges Leclercq; Tessa C C Kerre; Jean Plum
In vitro generation of immune cells from pluripotent stem cells.
Frontiers in bioscience : a journal and virtual library 2011;16():1488-504.
2009: Stefanie Van Coppernolle; Greet Verstichel; Frank Timmermans; Imke Velghe; David Vermijlen; Magda De Smedt; Georges Leclercq; Jean Plum; Tom Taghon; Bart Vandekerckhove; Tessa C C Kerre
Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;183(8):4859-70.
2009: Frank Timmermans; Imke Velghe; Lieve Vanwalleghem; Magda De Smedt; Stefanie Van Coppernolle; Tom Taghon; Harry D Moore; Georges Leclercq; Anton Langerak; Tessa C C Kerre; Jean Plum; Bart Vandekerckhove
Generation of T cells from human embryonic stem cell-derived hematopoietic zones.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(11):6879-88.
2009: Tom Taghon; Inge Van de Walle; Greet De Smet; Magda De Smedt; Georges Leclercq; Bart Vandekerckhove; Jean Plum
Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development.
Blood 2009;113(14):3254-63.
2009: Inge Van de Walle; Greet De Smet; Magda De Smedt; Bart Vandekerckhove; Georges Leclercq; Jean Plum; Tom Taghon
An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.
Blood 2009;113(13):2988-98.
2009: Tom Taghon
Regulation of early T cell development in mouse and human by Notch.
Verhandelingen - Koninklijke Academie voor Geneeskunde van België 2009;71(5):301-14.
2008: Tina Van Den Broeck; Frederik Stevenaert; Sylvie Taveirne; Veronique Debacker; Christel Vangestel; Bart Vandekerckhove; Tom Taghon; Patrick Matthys; Jean Plum; Werner Held; Mieke Dewerchin; Wayne M Yokoyama; Georges Leclercq
Ly49E-dependent inhibition of natural killer cells by urokinase plasminogen activator.
Blood 2008;112(13):5046-51.
2008: Tom Taghon; Ellen V Rothenberg
Molecular mechanisms that control mouse and human TCR-alphabeta and TCR-gammadelta T cell development.
Seminars in immunopathology 2008;30(4):383-98.
2008: Jean Plum; Magda De Smedt; Georges Leclercq; Tom Taghon; Tessa C C Kerre; Bart Vandekerckhove
Human intrathymic development: a selective approach.
Seminars in immunopathology 2008;30(4):411-23.
2007: Magda De Smedt; Tom Taghon; Inge Van de Walle; Greet De Smet; Georges Leclercq; Jean Plum
Notch signaling induces cytoplasmic CD3 epsilon expression in human differentiating NK cells.
Blood 2007;110(7):2696-703.
2007: Tom Taghon; Mary A Yui; Ellen V Rothenberg
Mast cell lineage diversion of T lineage precursors by the essential T cell transcription factor GATA-3.
Nature immunology 2007;8(8):845-55.
2007: Kaatje Smits; Magda De Smedt; Evelien Naessens; Greet De Smet; Veronique Stove; Tom Taghon; Jean Plum; Bruno Verhasselt
Tumor necrosis factor promotes T-cell at the expense of B-cell lymphoid development from cultured human CD34+ cord blood cells.
Experimental hematology 2007;35(8):1272-8.
2007: C Chace Tydell; Elizabeth-Sharon David-Fung; Jonathan E Moore; Lee Rowen; Tom Taghon; Ellen V Rothenberg
Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway.
Journal of immunology (Baltimore, Md. : 1950) 2007;179(1):421-38.
2006: Christopher B Franco; Deirdre D Scripture-Adams; Irina Proekt; Tom Taghon; Angela H Weiss; Mary A Yui; Stephanie L Adams; Rochelle A Diamond; Ellen V Rothenberg
Notch/Delta signaling constrains reengineering of pro-T cells by PU.1.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(32):11993-8.
2006: Elizabeth-Sharon David-Fung; Mary A Yui; Marissa Morales; Hua Wang; Tom Taghon; Rochelle A Diamond; Ellen V Rothenberg
Progression of regulatory gene expression states in fetal and adult pro-T-cell development.
Immunological reviews 2006;209():212-36.
2006: Tom Taghon; Mary A Yui; Rashmi Pant; Rochelle A Diamond; Ellen V Rothenberg
Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus.
Immunity 2006;24(1):53-64.
2005: Tom Taghon; Elizabeth-Sharon David; Juan Carlos Zúñiga-Pflücker; Ellen V Rothenberg
Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling.
Genes & development 2005;19(8):965-78.
2005: Ellen V Rothenberg; Tom Taghon
Molecular genetics of T cell development.
Annual review of immunology 2005;23():601-49.
2003: Tom Taghon; K Thys; Magda De Smedt; Floor Weerkamp; Frank Staal; Jean Plum; Georges Leclercq
Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development.
Leukemia 2003;17(6):1157-63.
2002: Magda De Smedt; Katia Reynvoet; Tessa C C Kerre; Tom Taghon; Bruno Verhasselt; Bart Vandekerckhove; Georges Leclercq; Jean Plum
Active form of Notch imposes T cell fate in human progenitor cells.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(6):3021-9.
2002: Tom Taghon; Frank Stolz; Magda De Smedt; Maggy Cnockaert; Bruno Verhasselt; Jean Plum; Georges Leclercq
HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor.
Blood 2002;99(4):1197-204.
2001: Tom Taghon; Magda De Smedt; Frank Stolz; M Cnockaert; Jean Plum; Georges Leclercq
Enforced expression of GATA-3 severely reduces human thymic cellularity.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(8):4468-75.
2000: An De Creus; Katrien van Beneden; Tom Taghon; Frank Stolz; Veronique Debacker; Jean Plum; Georges Leclercq
Langerhans cells that have matured in vivo in the absence of T cells are fully capable of inducing a helper CD4 as well as a cytotoxic CD8 response.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(2):645-53.