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Yu-Tzu Tai

Research Profile

Disorders

Multiple Myeloma

Anatomy

Chemicals & Drugs

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Publications

TOP 3
Lian Xu; Guang Yang; Yangsheng Zhou; Christina K Tripsas; Alessandra Trojani; Maria Varettoni; Kenneth C Anderson; Luca Arcaini; Jennifer R Brown; Yang Cao; Antonino Greco; Zachary R Hunter; Neal I Lindeman; Xia Liu; Robert J Manning; Enrica Morra; Nikhil C Munshi; Christopher J Patterson; Yu-Tzu Tai; Steve P Treon
MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction.
Ze Tian; Jian-jun Zhao; Samir B Amin; Allison J Berger; Dharminder Chauhan; Yiguo Hu; Paul Richardson; Yu-Tzu Tai; Kenneth C Anderson
Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells.
Michele Cea; Dharminder Chauhan; Francesca Cottini; Mariateresa Fulciniti; Marco Gobbi; Teru Hideshima; Jana Jakubikova; Sun-Young Kong; Nikhil Munshi; Alessio Nencioni; Franco Patrone; Paul Richardson; Aldo Roccaro; Antonio Sacco; Yu-Tzu Tai; Antonia Cagnetta; Teresa Calimeri; Kenneth C Anderson
Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.

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All Publications

2013: Lian Xu; Guang Yang; Yangsheng Zhou; Christina K Tripsas; Alessandra Trojani; Maria Varettoni; Kenneth C Anderson; Luca Arcaini; Jennifer R Brown; Yang Cao; Antonino Greco; Zachary R Hunter; Neal I Lindeman; Xia Liu; Robert J Manning; Enrica Morra; Nikhil C Munshi; Christopher J Patterson; Yu-Tzu Tai; Steve P Treon
MYD88 L265P in Waldenström macroglobulinemia, immunoglobulin M monoclonal gammopathy, and other B-cell lymphoproliferative disorders using conventional and quantitative allele-specific polymerase chain reaction.
Blood 2013;121(11):2051-8.
2012: Ze Tian; Jian-jun Zhao; Samir B Amin; Allison J Berger; Dharminder Chauhan; Yiguo Hu; Paul Richardson; Yu-Tzu Tai; Kenneth C Anderson
Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells.
Blood 2012;120(19):3958-67.
2012: Michele Cea; Dharminder Chauhan; Francesca Cottini; Mariateresa Fulciniti; Marco Gobbi; Teru Hideshima; Jana Jakubikova; Sun-Young Kong; Nikhil Munshi; Alessio Nencioni; Franco Patrone; Paul Richardson; Aldo Roccaro; Antonio Sacco; Yu-Tzu Tai; Antonia Cagnetta; Teresa Calimeri; Kenneth C Anderson
Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.
Blood 2012;120(17):3519-29.
2012: Yu-Tzu Tai; Kenneth C Anderson
Bruton's tyrosine kinase: oncotarget in myeloma.
Oncotarget 2012;3(9):913-4.
2012: Yu-Tzu Tai; Steve P Treon; Qiuju Wang; Guang Yang; Jian-Jun Zhao; Mike Y Zhong; Chirag Acharya; Joseph J Buggy; Antonia Cagnetta; Yolanda Calle; Daniel R Carrasco; Michele Cea; Betty Y Chang; Laurence Elias; Mariateresa Fulciniti; Yiguo Hu; Sun-Young Kong; Jianhong Lin; William Matsui; Nikhil C Munshi; Paul Richardson; Michael A Sellitto; Kenneth C Anderson
Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.
Blood 2012;120(9):1877-87.
2012: Naoya Mimura; Jiro Minami; Nikhil C Munshi; Hiroto Ohguchi; John B Patterson; Tuan Pham; Paul G Richardson; Loredana Santo; Yu-Tzu Tai; Victor Tam; Qingping Zeng; Martina Blumenthal; Diana Cirstea; Claire Fabre; Maureen French; Mariateresa Fulciniti; Gullu Gorgun; Mark Hokenson; Yiguo Hu; Hiroshi Ikeda; Yutaka Kawano; Nathalie L Kertesz; Tanyel Kiziltepe; Uriel M Malyankar; Kenneth C Anderson
Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma.
Blood 2012;119(24):5772-81.
2012: Merav Leiba; Constantine S Mitsiades; Arnon Nagler; Mark Pines; Paul G Richardson; Yu-Tzu Tai; Teru Hideshima; Jana Jakubikova; Steffen Klippel; Adi Leiba; Kenneth C Anderson
Halofuginone inhibits multiple myeloma growth in vitro and in vivo and enhances cytotoxicity of conventional and novel agents.
British journal of haematology 2012;157(6):718-31.
2012: Jagannath Pal; Yu-Tzu Tai; Pierfrancesco Tassone; Leutz Buon; Mariateresa Fulciniti; Nikhil C Munshi; Puru Nanjappa; Masood A Shammas
Targeting PI3K and RAD51 in Barrett's adenocarcinoma: impact on DNA damage checkpoints, expression profile and tumor growth.
Cancer genomics & proteomics 2012;9(2):55-66.
2012: Yu-Tzu Tai; Nikhil C Munshi; Duc-Hanh T Nguyen; Erik Pong; Kenneth C Anderson; Matthew J Bernett; Saso Cemerski; Hsing Chen; Seung Y Chu; John Desjarlais; Holly M Horton; Sher Karki; Sun-Young Kong; Greg A Lazar; Umesh S Muchhal
Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function.
Blood 2012;119(9):2074-82.
2011: Triona Ni Chonghaile; Paul Richardson; Jeremy A Ryan; Stephen E Sallan; Kristopher A Sarosiek; Lewis Silverman; Richard Stone; Yu-Tzu Tai; Anupama Tammareddi; Thanh-Trang Vo; Kenneth C Anderson; Daniel Ruben Carrasco; Daniel J DeAngelo; Jing Deng; Ronny Drapkin; Michelle S Hirsch; Ursula A Matulonis; David J McConkey; Constantine S Mitsiades; Victoria Del Gaizo Moore; Anthony Letai
Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy.
Science (New York, N.Y.) 2011;334(6059):1129-33.
2011: klaus podar; Martin Sattler; Yu-Tzu Tai; Giovanni Tonon; Sonia Vallet; Alexander Zimmerhackl; Dharminder Chauhan; Mariateresa Fulciniti; Ursula Hainz; Niels Halama; Dirk Jäger; Dian L Olson; Kenneth C Anderson
The selective adhesion molecule inhibitor Natalizumab decreases multiple myeloma cell growth in the bone marrow microenvironment: therapeutic implications.
British journal of haematology 2011;155(4):438-48.
2011: Mariateresa Fulciniti; Teru Hideshima; Cheng Li; Stephane Minvielle; Puru Nanjappa; Rao Prabhala; Scott Rodig; Yu-Tzu Tai; Pierfrancesco Tassone; Samir Amin; Kenneth C Anderson; Herve Avet-Loiseau; Nikhil C Munshi
Significant biological role of sp1 transactivation in multiple myeloma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(20):6500-9.
2011: Yu-Tzu Tai; Kenneth C Anderson
Antibody-based therapies in multiple myeloma.
Bone marrow research 2011;2011():924058.
2011: W Song; Yu-Tzu Tai; Z Tian; Teru Hideshima; Dharminder Chauhan; P Nanjappa; Mark A Exley; Kenneth C Anderson; Nikhil C Munshi
HDAC inhibition by LBH589 affects the phenotype and function of human myeloid dendritic cells.
Leukemia 2011;25(1):161-8.
2010: Güllü Görgün; Elisabetta Calabrese; Ender Soydan; Teru Hideshima; Giulia Perrone; Madhavi Bandi; Diana Cirstea; Loredana Santo; Yiguo Hu; Yu-Tzu Tai; Sabikun Nahar; Naoya Mimura; Claire Fabre; Noopur Raje; Nikhil Munshi; Paul Richardson; Kenneth C Anderson
Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma.
Blood 2010;116(17):3227-37.
2010: Moshe E Gatt; Roi Gazit; Mala Mani; Stéphane Minvielle; Nikhil C Munshi; Yu-Tzu Tai; Yunyu Zhang; Jian-Jun Zhao; Sophia Adamia; Kenneth C Anderson; Hervé Avet-Loiseau; Daniel E Carrasco; Zhangbo Chu; Jui Dutta-Simmons; Margaret S Ebert; Daniel R Carrasco
MicroRNAs 15a/16-1 function as tumor suppressor genes in multiple myeloma.
Blood 2010;():.
2010: Rao H Prabhala; dheeraj pelluru; Mariateresa Fulciniti; Harsha K Prabhala; Puru Nanjappa; Weihua Song; Christine Pai; Samir Amin; Yu-Tzu Tai; Paul G Richardson; Irene M Ghobrial; Steve P Treon; John F Daley; Kenneth C Anderson; Jeffery L Kutok; Nikhil C Munshi
Elevated IL-17 produced by TH17 cells promotes myeloma cell growth and inhibits immune function in multiple myeloma.
Blood 2010;115(26):5385-92.
2010: Güllü Görgün; Elisabetta Calabrese; Teru Hideshima; Jeffrey Ecsedy; Giulia Perrone; Mala Mani; Hiroshi Ikeda; Giada Bianchi; Yiguo Hu; Diana Cirstea; Loredana Santo; Yu-Tzu Tai; Sabikun Nahar; Mei Zheng; Madhavi Bandi; Ruben D Carrasco; Noopur Raje; Nikhil Munshi; Paul Richardson; Kenneth C Anderson
A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell-cycle arrest in multiple myeloma.
Blood 2010;115(25):5202-13.
2010: Kihyun Kim; Sun-Young Kong; Mariateresa Fulciniti; Xianfeng Li; Weihua Song; Sabikun Nahar; Peter C Burger; Mathew J Rumizen; klaus podar; Dharminder Chauhan; Teru Hideshima; Nikhil C Munshi; Paul Richardson; Ann Clark; Janet Ogden; Andreas Goutopoulos; Luca Rastelli; Kenneth C Anderson; Yu-Tzu Tai
Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti-myeloma activity in vitro and in vivo.
British journal of haematology 2010;149(4):537-49.
2010: James J Driscoll; dheeraj pelluru; Konstantinos Lefkimmiatis; Mariateresa Fulciniti; Rao H Prabhala; Philip R Greipp; Bart Barlogie; Yu-Tzu Tai; Kenneth C Anderson; John D Shaughnessy; Christina M Annunziata; Nikhil C Munshi
The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome.
Blood 2010;115(14):2827-34.
2009: Simona Blotta; Pierfrancesco Tassone; Rao H Prabhala; Pierosandro Tagliaferri; David Cervi; Samir Amin; Jana Jakubikova; Yu-Tzu Tai; klaus podar; Constantine S Mitsiades; Alessandro Zullo; Brunella Franco; Kenneth C Anderson; Nikhil C Munshi
Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance.
Blood 2009;114(15):3276-84.
2009: Jui Dutta-Simmons; Yunyu Zhang; Gullu T Gorgun; Moshe Gatt; Mala Mani; Teru Hideshima; Kohichi Takada; Nicole E Carlson; Daniel E Carrasco; Yu-Tzu Tai; Noopur Raje; Anthony Letai; Kenneth C Anderson; Daniel R Carrasco
Aurora kinase A is a target of Wnt/beta-catenin involved in multiple myeloma disease progression.
Blood 2009;114(13):2699-708.
2009: Mariateresa Fulciniti; Pierfrancesco Tassone; Teru Hideshima; Sonia Vallet; Puru Nanjappa; Seth A Ettenberg; Zhenxin Shen; Nipun Patel; Yu-Tzu Tai; Dharminder Chauhan; Constantine S Mitsiades; Rao H Prabhala; Noopur Raje; Kenneth C Anderson; David R Stover; Nikhil C Munshi
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma.
Blood 2009;114(2):371-9.
2009: Jing Zhang; Martin Sattler; Giovanni Tonon; Clemens Grabher; Samir Lababidi; Alexander Zimmerhackl; Marc S Raab; Sonia Vallet; Yiming Zhou; Marie-Astrid Cartron; Teru Hideshima; Yu-Tzu Tai; Dharminder Chauhan; Kenneth C Anderson; Klaus Podar
Targeting angiogenesis via a c-Myc/hypoxia-inducible factor-1alpha-dependent pathway in multiple myeloma.
Cancer research 2009;69(12):5082-90.
2009: Hiroshi Ikeda; Teru Hideshima; Mariateresa Fulciniti; Robert J Lutz; Hiroshi Yasui; Yutaka Okawa; Tanyel Kiziltepe; Sonia Vallet; Samantha Pozzi; Loredana Santo; Giulia Perrone; Yu-Tzu Tai; Diana Cirstea; Noopur S Raje; Christoph Uherek; Benjamin Dälken; Silke Aigner; Frank Osterroth; Nikhil Munshi; Paul G Richardson; Kenneth C Anderson
The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):4028-37.
2009: Yu-Tzu Tai; Ender Soydan; Weihua Song; Mariateresa Fulciniti; Kihyun Kim; Fangxin Hong; Xian-Feng Li; Peter C Burger; Matthew J Rumizen; Sabikun Nahar; klaus podar; Teru Hideshima; Nikhil C Munshi; Giovanni Tonon; Ruben D Carrasco; Daniel E H Afar; Kenneth C Anderson
CS1 promotes multiple myeloma cell adhesion, clonogenic growth, and tumorigenicity via c-maf-mediated interactions with bone marrow stromal cells.
Blood 2009;113(18):4309-18.
2009: klaus podar; Yu-Tzu Tai; Teru Hideshima; Sonia Vallet; Paul G Richardson; Kenneth C Anderson
Emerging therapies for multiple myeloma.
Expert opinion on emerging drugs 2009;14(1):99-127.
2009: Renate Burger; Steven Le Gouill; Yu-Tzu Tai; Reshma Shringarpure; Pierfrancesco Tassone; Paola Neri; klaus podar; Laurence Catley; Teru Hideshima; Dharminder Chauhan; Eian Caulder; Claire L Neilan; Kris Vaddi; Jun Li; Martin Gramatzki; Jordan S Fridman; Kenneth C Anderson
Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo.
Molecular cancer therapeutics 2009;8(1):26-35.
2008: Yu-Tzu Tai; Myles Dillon; Weihua Song; Merav Leiba; Xian-Feng Li; Peter C Burger; Alfred I Lee; klaus podar; Teru Hideshima; Audie G Rice; A van Abbema; Lynne Jesaitis; Ingrid Caras; Debbie Law; Edie Weller; Wanling Xie; Paul G Richardson; Nikhil C Munshi; Claire Mathiot; Hervé Avet-Loiseau; Daniel E H Afar; Kenneth C Anderson
Anti-CS1 humanized monoclonal antibody HuLuc63 inhibits myeloma cell adhesion and induces antibody-dependent cellular cytotoxicity in the bone marrow milieu.
Blood 2008;112(4):1329-37.
2008: Noopur Raje; Sook-Bin Woo; Karen Hande; Jeff T Yap; Paul G Richardson; Sonia Vallet; Nathaniel S Treister; Teru Hideshima; Niall Sheehy; Shweta Chhetri; Brendan Connell; Wanling Xie; Yu-Tzu Tai; Agnieszka Szot-Barnes; Mei Tian; Robert Schlossman; Edie Weller; Nikhil C Munshi; Annick D Van den Abbeele; Kenneth C Anderson
Clinical, radiographic, and biochemical characterization of multiple myeloma patients with osteonecrosis of the jaw.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(8):2387-95.
2008: Alissa Huston; Xavier Leleu; Xiaoying Jia; Anne-Sophie Moreau; Hai T Ngo; Judith Runnels; Judy Anderson; Yazan Alsayed; Aldo Roccaro; Sonia Vallet; Evdoxia Hatjiharissi; Yu-Tzu Tai; Peter Sportelli; Nikhil C Munshi; Paul G Richardson; Teru Hideshima; David G Roodman; Kenneth C Anderson; Irene M Ghobrial
Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(3):865-74.
2008: klaus podar; S L Gouill; J Zhang; J T Opferman; E Zorn; Yu-Tzu Tai; Teru Hideshima; M Amiot; Dharminder Chauhan; Jean-Luc Harousseau; Kenneth C Anderson
A pivotal role for Mcl-1 in Bortezomib-induced apoptosis.
Oncogene 2008;27(6):721-31.
2008: Masahisa Jinushi; Matthew Vanneman; Nikhil C Munshi; Yu-Tzu Tai; Rao H Prabhala; Jerome Ritz; Donna Neuberg; Kenneth C Anderson; Daniel R Carrasco; Glenn Dranoff
MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(4):1285-90.
2007: Paola Neri; Shaji Kumar; Mariateresa Fulciniti; Sonia Vallet; Shweta Chhetri; Sidhartha Mukherjee; Yu-Tzu Tai; Dharminder Chauhan; Pierfrancesco Tassone; Salvatore Venuta; Nikhil C Munshi; Teru Hideshima; Kenneth C Anderson; Noopur Raje
Neutralizing B-cell activating factor antibody improves survival and inhibits osteoclastogenesis in a severe combined immunodeficient human multiple myeloma model.
Clinical cancer research : an official journal of the American Association for Cancer Research 2007;13(19):5903-9.
2007: Daniel Ditzel Santos; Allen W Ho; Olivier Tournilhac; Evdoxia Hatjiharissi; Xavier Leleu; Lian Xu; Pierfrancesco Tassone; Paola Neri; Zachary R Hunter; Mariana A Z Chemaly; Andrew R Branagan; Robert J Manning; Christopher J Patterson; Anne-Sophie Moreau; Bryan Ciccarelli; Sophia Adamia; Jitra Kriangkum; Jeffery L Kutok; Yu-Tzu Tai; Jiangwen Zhang; Linda M Pilarski; Kenneth C Anderson; Nikhil C Munshi; Steve P Treon
Establishment of BCWM.1 cell line for Waldenström's macroglobulinemia with productive in vivo engraftment in SCID-hu mice.
Experimental hematology 2007;35(9):1366-75.
2007: Teru Hideshima; Laurence Catley; Noopur Raje; Dharminder Chauhan; klaus podar; Constantine S Mitsiades; Yu-Tzu Tai; Sonia Vallet; Tanyel Kiziltepe; Enrique M Ocio; Hiroshi Ikeda; Yutaka Okawa; Hiromasa Hideshima; Nikhil C Munshi; Hiroshi Yasui; Paul G Richardson; Kenneth C Anderson
Inhibition of Akt induces significant downregulation of survivin and cytotoxicity in human multiple myeloma cells.
British journal of haematology 2007;138(6):783-91.
2007: Yu-Tzu Tai; Mariateresa Fulciniti; Teru Hideshima; Weihua Song; Merav Leiba; Xian-Feng Li; Matthew Rumizen; Peter C Burger; Aileen Morrison; klaus podar; Dharminder Chauhan; Pierfrancesco Tassone; Paul Richardson; Nikhil C Munshi; Irene M Ghobrial; Kenneth C Anderson
Targeting MEK induces myeloma-cell cytotoxicity and inhibits osteoclastogenesis.
Blood 2007;110(5):1656-63.
2007: Laurence Catley; Teru Hideshima; Dharminder Chauhan; Paola Neri; Pierfrancesco Tassone; Roderick Bronson; Weihua Song; Yu-Tzu Tai; Nikhil C Munshi; Kenneth C Anderson
Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model.
Experimental hematology 2007;35(7):1038-46.
2007: Jooeun Bae; Constantine S Mitsiades; Yu-Tzu Tai; Robert C Bertheau; Masood Ahmad Shammas; Ramesh Babu Batchu; Cheng Li; Laurence Catley; Rao H Prabhala; Kenneth C Anderson; Nikhil C Munshi
Phenotypic and functional effects of heat shock protein 90 inhibition on dendritic cell.
Journal of immunology (Baltimore, Md. : 1950) 2007;178(12):7730-7.
2007: Kumar Sukhdeo; Mala Mani; Yunyu Zhang; Jui Dutta; Hiroshi Yasui; Melissa D Rooney; Daniel E Carrasco; Mei Zheng; Haiying He; Yu-Tzu Tai; Constantine S Mitsiades; Kenneth C Anderson; Daniel R Carrasco
Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(18):7516-21.
2007: klaus podar; Marc S Raab; Giovanni Tonon; Martin Sattler; Daniela Barilà; Jing Zhang; Yu-Tzu Tai; Hiroshi Yasui; Noopur Raje; Ronald A DePinho; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
Up-regulation of c-Jun inhibits proliferation and induces apoptosis via caspase-triggered c-Abl cleavage in human multiple myeloma.
Cancer research 2007;67(4):1680-8.
2007: klaus podar; Marc S Raab; Jing Zhang; Douglas W McMillin; Iris Breitkreutz; Yu-Tzu Tai; Boris K Lin; Nikhil C Munshi; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
Targeting PKC in multiple myeloma: in vitro and in vivo effects of the novel, orally available small-molecule inhibitor enzastaurin (LY317615.HCl).
Blood 2007;109(4):1669-77.
2006: klaus podar; Giovanni Tonon; Martin Sattler; Yu-Tzu Tai; Steven Legouill; Hiroshi Yasui; Kenji Ishitsuka; Shaji Kumar; Rakesh Kumar; Lini Pandite; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
The small-molecule VEGF receptor inhibitor pazopanib (GW786034B) targets both tumor and endothelial cells in multiple myeloma.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(51):19478-83.
2006: Laurence Catley; Ellen Weisberg; Tanyel Kiziltepe; Yu-Tzu Tai; Teru Hideshima; Paola Neri; Pierfrancesco Tassone; Peter Atadja; Dharminder Chauhan; Nikhil C Munshi; Kenneth C Anderson
Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells.
Blood 2006;108(10):3441-9.
2006: Masood Ahmad Shammas; Paola Neri; Hemanta Koley; Ramesh Babu Batchu; Robert C Bertheau; Vidit Munshi; Rao H Prabhala; Mariateresa Fulciniti; Yu-Tzu Tai; Steve P Treon; Raj K Goyal; Kenneth C Anderson; Nikhil C Munshi
Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications.
Blood 2006;108(8):2804-10.
2006: Olivier Tournilhac; Daniel Ditzel Santos; Lian Xu; Jeffery L Kutok; Yu-Tzu Tai; Steven Le Gouill; Laurence Catley; Zachary R Hunter; Andrew R Branagan; J A Boyce; Nikhil C Munshi; Kenneth C Anderson; Steve P Treon
Mast cells in Waldenstrom's macroglobulinemia support lymphoplasmacytic cell growth through CD154/CD40 signaling.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2006;17(8):1275-82.
2006: Reshma Shringarpure; Laurence Catley; Deepak Bhole; Renate Burger; klaus podar; Yu-Tzu Tai; Benedikt Kessler; Paul J Galardy; Hidde L Ploegh; Pierfrancesco Tassone; Teru Hideshima; Constantine S Mitsiades; Nikhil C Munshi; Dharminder Chauhan; Kenneth C Anderson
Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib.
British journal of haematology 2006;134(2):145-56.
2006: Yu-Tzu Tai; Xian-Feng Li; Iris Breitkreutz; Weihua Song; Paola Neri; Laurence Catley; klaus podar; Teru Hideshima; Dharminder Chauhan; Noopur Raje; Robert Schlossman; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment.
Cancer research 2006;66(13):6675-82.
2006: Daniel Ditzel Santos; Evdoxia Hatjiharissi; Olivier Tournilhac; Mariana Z A Chemaly; Xavier Leleu; Lian Xu; Christopher Patterson; Andrew R Branagan; Robert J Manning; Allen W Ho; Zachary R Hunter; Elizabeth A Dimmock; Jeffery L Kutok; Winthrop H Churchill; Mariana C Castells; Yu-Tzu Tai; Kenneth C Anderson; Steve P Treon
CD52 is expressed on human mast cells and is a potential therapeutic target in Waldenstrom's Macroglobulinemia and mast cell disorders.
Clinical lymphoma & myeloma 2006;6(6):478-83.
2005: Yu-Tzu Tai; Xian-Feng Li; Laurence Catley; Rory Coffey; Iris Breitkreutz; Jooeun Bae; Weihua Song; klaus podar; Teru Hideshima; Dharminder Chauhan; Robert Schlossman; Paul Richardson; Steve P Treon; Iqbal Grewal; Nikhil C Munshi; Kenneth C Anderson
Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: clinical implications.
Cancer research 2005;65(24):11712-20.
2005: Hiroshi Yasui; Teru Hideshima; Noopur Raje; Aldo Roccaro; Norihiko Shiraishi; Shaji Kumar; Makoto Hamasaki; Kenji Ishitsuka; Yu-Tzu Tai; klaus podar; Laurence Catley; Constantine S Mitsiades; Paul G Richardson; Rainer Albert; Volker Brinkmann; Dharminder Chauhan; Kenneth C Anderson
FTY720 induces apoptosis in multiple myeloma cells and overcomes drug resistance.
Cancer research 2005;65(16):7478-84.
2005: Laurence Catley; Yu-Tzu Tai; Dharminder Chauhan; Kenneth C Anderson
Perspectives for combination therapy to overcome drug-resistant multiple myeloma.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 2005;8(4):205-18.
2005: Hiroshi Yasui; Teru Hideshima; Makoto Hamasaki; Aldo Roccaro; Norihiko Shiraishi; Shaji Kumar; Pierfrancesco Tassone; Kenji Ishitsuka; Noopur Raje; Yu-Tzu Tai; klaus podar; Dharminder Chauhan; Lorenzo Leoni; Sarath Kanekal; Gary Elliott; Nikhil C Munshi; Kenneth C Anderson
SDX-101, the R-enantiomer of etodolac, induces cytotoxicity, overcomes drug resistance, and enhances the activity of dexamethasone in multiple myeloma.
Blood 2005;106(2):706-12.
2005: Yu-Tzu Tai; Xianfeng Li; Xia Tong; Daniel Santos; Takemi Otsuki; Laurence Catley; Olivier Tournilhac; klaus podar; Teru Hideshima; Robert Schlossman; Paul Richardson; Nikhil C Munshi; Mohammad Luqman; Kenneth C Anderson
Human anti-CD40 antagonist antibody triggers significant antitumor activity against human multiple myeloma.
Cancer research 2005;65(13):5898-906.
2005: Kip M Connor; Sita Subbaram; Kevin J Regan; Kristin K Nelson; Joseph E Mazurkiewicz; Peter J Bartholomew; Andrew E. Aplin; Yu-Tzu Tai; Julio A Aguirre Ghiso; Sonia C Flores; J Andres Melendez
Mitochondrial H2O2 regulates the angiogenic phenotype via PTEN oxidation.
The Journal of biological chemistry 2005;280(17):16916-24.
2005: Boris Lin; Laurence Catley; Richard LeBlanc; Constantine S Mitsiades; Renate Burger; Yu-Tzu Tai; klaus podar; Markus Wartmann; Dharminder Chauhan; James D Griffin; Kenneth C Anderson
Patupilone (epothilone B) inhibits growth and survival of multiple myeloma cells in vitro and in vivo.
Blood 2005;105(1):350-7.
2004: Laurence Catley; Yu-Tzu Tai; Reshma Shringarpure; Renate Burger; Moni Thi Son; klaus podar; Pierfrancesco Tassone; Dharminder Chauhan; Teru Hideshima; Louis Denis; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
Proteasomal degradation of topoisomerase I is preceded by c-Jun NH2-terminal kinase activation, Fas up-regulation, and poly(ADP-ribose) polymerase cleavage in SN38-mediated cytotoxicity against multiple myeloma.
Cancer research 2004;64(23):8746-53.
2004: Teru Hideshima; klaus podar; Dharminder Chauhan; Kenji Ishitsuka; Constantine S Mitsiades; Yu-Tzu Tai; Makoto Hamasaki; Noopur Raje; Hiromasa Hideshima; George F Schreiner; Aaron N Nguyen; Tony A Navas; Nikhil C Munshi; Paul G Richardson; Linda S Higgins; Kenneth C Anderson
p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells.
Oncogene 2004;23(54):8766-76.
2004: klaus podar; Reshma Shringarpure; Yu-Tzu Tai; Melissa Simoncini; Martin Sattler; Kenji Ishitsuka; Paul G Richardson; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib.
Cancer research 2004;64(20):7500-6.
2004: klaus podar; Gustavo Mostoslavsky; Martin Sattler; Yu-Tzu Tai; Toshiaki Hayashi; Laurence Catley; Teru Hideshima; Richard C Mulligan; Dharminder Chauhan; Kenneth C Anderson
Critical role for hematopoietic cell kinase (Hck)-mediated phosphorylation of Gab1 and Gab2 docking proteins in interleukin 6-induced proliferation and survival of multiple myeloma cells.
The Journal of biological chemistry 2004;279(20):21658-65.
2004: Noopur Raje; Teru Hideshima; Faith E Davies; Dharminder Chauhan; Steve P Treon; Gloria Young; Yu-Tzu Tai; David Avigan; Jianlin Gong; Robert Schlossman; Paul Richardson; Donald Kufe; Kenneth C Anderson
Tumour cell/dendritic cell fusions as a vaccination strategy for multiple myeloma.
British journal of haematology 2004;125(3):343-52.
2004: klaus podar; Laurence Catley; Yu-Tzu Tai; Reshma Shringarpure; Pedro Carvalho; Toshiaki Hayashi; Renate Burger; Robert Schlossman; Paul G Richardson; Lini Pandite; Rakesh Kumar; Teru Hideshima; Dharminder Chauhan; Kenneth C Anderson
GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Blood 2004;103(9):3474-9.
2004: Yu-Tzu Tai; Laurence Catley; Constantine S Mitsiades; Renate Burger; klaus podar; Reshma Shringpaure; Teru Hideshima; Dharminder Chauhan; Makoto Hamasaki; Kenji Ishitsuka; Paul Richardson; Steve P Treon; Nikhil C Munshi; Kenneth C Anderson
Mechanisms by which SGN-40, a humanized anti-CD40 antibody, induces cytotoxicity in human multiple myeloma cells: clinical implications.
Cancer research 2004;64(8):2846-52.
2004: Dharminder Chauhan; Guilan Li; klaus podar; Teru Hideshima; Reshma Shringarpure; Laurence Catley; Constantine S Mitsiades; Nikhil C Munshi; Yu-Tzu Tai; Nanjoo Suh; Gordon W Gribble; Tadashi Honda; Robert Schlossman; Paul Richardson; Michael B. Sporn; Kenneth C Anderson
The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance.
Blood 2004;103(8):3158-66.
2003: Renate Burger; Frank Bakker; Andreas Guenther; Wolfgang Baum; Dirk Schmidt-Arras; Teru Hideshima; Yu-Tzu Tai; Reshma Shringarpure; Laurence Catley; Giorgio Senaldi; Martin Gramatzki; Kenneth C Anderson
Functional significance of novel neurotrophin-1/B cell-stimulating factor-3 (cardiotrophin-like cytokine) for human myeloma cell growth and survival.
British journal of haematology 2003;123(5):869-78.
2003: Dharminder Chauhan; Guilan Li; Teru Hideshima; klaus podar; Constantine S Mitsiades; Nicholas Mitsiades; Laurence Catley; Yu-Tzu Tai; Toshiaki Hayashi; Reshma Shringarpure; Renate Burger; Nikhil C Munshi; Yasuyuki Ohtake; Satya Saxena; Kenneth C Anderson
Hsp27 inhibits release of mitochondrial protein Smac in multiple myeloma cells and confers dexamethasone resistance.
Blood 2003;102(9):3379-86.
2003: Masaharu Akiyama; Teru Hideshima; Masood Ahmad Shammas; Toshiaki Hayashi; Makoto Hamasaki; Yu-Tzu Tai; Paul Richardson; Sergei Gryaznov; Nikhil C Munshi; Kenneth C Anderson
Effects of oligonucleotide N3'-->P5' thio-phosphoramidate (GRN163) targeting telomerase RNA in human multiple myeloma cells.
Cancer research 2003;63(19):6187-94.
2003: Laurence Catley; Ellen Weisberg; Yu-Tzu Tai; Peter Atadja; Stacy W Remiszewski; Teru Hideshima; Nicholas Mitsiades; Reshma Shringarpure; Richard LeBlanc; Dharminder Chauhan; Nikhil C Munshi; Robert Schlossman; Paul Richardson; James Griffin; Kenneth C Anderson
NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma.
Blood 2003;102(7):2615-22.
2003: Yu-Tzu Tai; klaus podar; Laurence Catley; Yu-Hua Tseng; Masaharu Akiyama; Reshma Shringarpure; Renate Burger; Teru Hideshima; Dharminder Chauhan; Nicholas Mitsiades; Paul Richardson; Nikhil C Munshi; C Ronald Kahn; Constantine S Mitsiades; Kenneth C Anderson
Insulin-like growth factor-1 induces adhesion and migration in human multiple myeloma cells via activation of beta1-integrin and phosphatidylinositol 3'-kinase/AKT signaling.
Cancer research 2003;63(18):5850-8.
2003: Toshiaki Hayashi; Steve P Treon; Teru Hideshima; Yu-Tzu Tai; Masaharu Akiyama; Paul Richardson; Dharminder Chauhan; Iqbal Grewal; Kenneth C Anderson
Recombinant humanized anti-CD40 monoclonal antibody triggers autologous antibody-dependent cell-mediated cytotoxicity against multiple myeloma cells.
British journal of haematology 2003;121(4):592-6.
2003: Yu-Tzu Tai; klaus podar; Nicholas Mitsiades; Boris Lin; Constantine S Mitsiades; Deepak Gupta; Masaharu Akiyama; Laurence Catley; Teru Hideshima; Nikhil C Munshi; Steve P Treon; Kenneth C Anderson
CD40 induces human multiple myeloma cell migration via phosphatidylinositol 3-kinase/AKT/NF-kappa B signaling.
Blood 2003;101(7):2762-9.
2003: Nicholas Mitsiades; Constantine S Mitsiades; Paul G Richardson; Vassiliki Poulaki; Yu-Tzu Tai; Dharminder Chauhan; Galinos Fanourakis; Xuesong Gu; Charles Bailey; Marie Joseph; Towia Libermann; Robert Schlossman; Nikhil C Munshi; Teru Hideshima; Kenneth C Anderson
The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications.
Blood 2003;101(6):2377-80.
2003: klaus podar; Yu-Tzu Tai; Craig E Cole; Teru Hideshima; Martin Sattler; Angela Hamblin; Nicholas Mitsiades; Robert Schlossman; Faith E Davies; Gareth J Morgan; Nikhil C Munshi; Dharminder Chauhan; Kenneth C Anderson
Essential role of caveolae in interleukin-6- and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells.
The Journal of biological chemistry 2003;278(8):5794-801.
2003: Masaharu Akiyama; Teru Hideshima; Toshiaki Hayashi; Yu-Tzu Tai; Constantine S Mitsiades; Nicholas Mitsiades; Dharminder Chauhan; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein.
Cancer research 2003;63(1):18-21.
2002: Boris Lin; klaus podar; Deepak Gupta; Yu-Tzu Tai; Sigui Li; Edie Weller; Teru Hideshima; Suzanne Lentzsch; Faith Davies; Cheng Li; Ellen Weisberg; Robert Schlossman; Paul G Richardson; James D Griffin; Jeanette Wood; Nikhil C Munshi; Kenneth C Anderson
The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment.
Cancer research 2002;62(17):5019-26.
2002: Deepak Gupta; klaus podar; Yu-Tzu Tai; Boris Lin; Teru Hideshima; Masaharu Akiyama; Richard LeBlanc; Laurence Catley; Nicholas Mitsiades; Constantine S Mitsiades; Dharminder Chauhan; Nikhil C Munshi; Kenneth C Anderson
beta-lapachone, a novel plant product, overcomes drug resistance in human multiple myeloma cells.
Experimental hematology 2002;30(7):711-20.
2002: Masaharu Akiyama; Teru Hideshima; Toshiaki Hayashi; Yu-Tzu Tai; Constantine S Mitsiades; Nicholas Mitsiades; Dharminder Chauhan; Paul Richardson; Nikhil C Munshi; Kenneth C Anderson
Cytokines modulate telomerase activity in a human multiple myeloma cell line.
Cancer research 2002;62(13):3876-82.
2002: klaus podar; Yu-Tzu Tai; Boris K Lin; Radha P Narsimhan; Martin Sattler; Takashi Kijima; Ravi Salgia; Deepak Gupta; Dharminder Chauhan; Kenneth C Anderson
Vascular endothelial growth factor-induced migration of multiple myeloma cells is associated with beta 1 integrin- and phosphatidylinositol 3-kinase-dependent PKC alpha activation.
The Journal of biological chemistry 2002;277(10):7875-81.
2002: Yu-Tzu Tai; klaus podar; Stine-Kathrein Kraeft; Fengfei Wang; Gloria Young; Boris Lin; Deepak Gupta; Lan Bo Chen; Kenneth C Anderson
Translocation of Ku86/Ku70 to the multiple myeloma cell membrane: functional implications.
Experimental hematology 2002;30(3):212-20.
2002: Yu-Tzu Tai; klaus podar; Deepak Gupta; Boris Lin; Gloria Young; Masaharu Akiyama; Kenneth C Anderson
CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma cells.
Blood 2002;99(4):1419-27.
2001: Deepak Gupta; Steve P Treon; Y Shima; Teru Hideshima; klaus podar; Yu-Tzu Tai; Boris Lin; Suzanne Lentzsch; Faith E Davies; Dharminder Chauhan; Robert Schlossman; Paul Richardson; P Ralph; Lei Wu; Faribourz Payvandi; G Muller; David I Stirling; Kenneth C Anderson
Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications.
Leukemia 2001;15(12):1950-61.
2001: klaus podar; Yu-Tzu Tai; Faith E Davies; Suzanne Lentzsch; Martin Sattler; Teru Hideshima; Boris K Lin; Deepak Gupta; Y Shima; Dharminder Chauhan; Constantine S Mitsiades; Noopur Raje; Paul Richardson; Kenneth C Anderson
Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration.
Blood 2001;98(2):428-35.
2001: Faith E Davies; Noopur Raje; Teru Hideshima; Suzanne Lentzsch; Gloria Young; Yu-Tzu Tai; Boris Lin; klaus podar; Deepak Gupta; Dharminder Chauhan; Steve P Treon; Paul G Richardson; Robert Schlossman; G J Morgan; George W Muller; David I Stirling; Kenneth C Anderson
Thalidomide and immunomodulatory derivatives augment natural killer cell cytotoxicity in multiple myeloma.
Blood 2001;98(1):210-6.
2000: Yu-Tzu Tai; G Teoh; Boris Lin; FE Davies; Dharminder Chauhan; Steve P Treon; Noopur Raje; Teru Hideshima; Y Shima; klaus podar; Kenneth C Anderson
Ku86 variant expression and function in multiple myeloma cells is associated with increased sensitivity to DNA damage.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(11):6347-55.
2000: Steve P Treon; P Maimonis; D Bua; Gloria Young; Noopur Raje; Joseph A Mollick; Dharminder Chauhan; Yu-Tzu Tai; Teru Hideshima; Y Shima; JH Hilgers; Silvia von Mensdorff-Pouilly; Andrew R Belch; Linda M Pilarski; Kenneth C Anderson
Elevated soluble MUC1 levels and decreased anti-MUC1 antibody levels in patients with multiple myeloma.
Blood 2000;96(9):3147-53.
2000: Teru Hideshima; Dharminder Chauhan; Y Shima; Noopur Raje; Faith E Davies; Yu-Tzu Tai; Steve P Treon; Boris Lin; Robert Schlossman; Paul Richardson; G Muller; David I Stirling; Kenneth C Anderson
Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy.
Blood 2000;96(9):2943-50.
2000: Dharminder Chauhan; Pramod Pandey; Teru Hideshima; Steve P Treon; Noopur Raje; Faith E Davies; Y Shima; Yu-Tzu Tai; S Rosen; S Avraham; Surender Kharbanda; Kenneth C Anderson
SHP2 mediates the protective effect of interleukin-6 against dexamethasone-induced apoptosis in multiple myeloma cells.
The Journal of biological chemistry 2000;275(36):27845-50.
2000: Noopur Raje; G Kica; Dharminder Chauhan; Yana Zhang; G Teoh; Steve P Treon; Teru Hideshima; Jian-Hong Deng; Shou-Jiang Gao; M Alsina; J Wally; FE Davies; Yu-Tzu Tai; Geraldine S Pinkus; Jack L Pinkus; Martha Skinner; Raymond Comenzo; Kenneth C Anderson
Kaposi's sarcoma-associated herpesvirus gene sequences are detectable at low copy number in primary amyloidosis.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis 2000;7(2):126-32.
2000: Teru Hideshima; Dharminder Chauhan; G Teoh; Noopur Raje; Steve P Treon; Yu-Tzu Tai; Y Shima; Kenneth C Anderson
Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6.
Clinical cancer research : an official journal of the American Association for Cancer Research 2000;6(3):1180-9.
2000: Yu-Tzu Tai; G Teoh; Y Shima; Dharminder Chauhan; Steve P Treon; Noopur Raje; Teru Hideshima; FE Davies; Kenneth C Anderson
Isolation and characterization of human multiple myeloma cell enriched populations.
Journal of immunological methods 2000;235(1-2):11-9.
2000: G Teoh; Yu-Tzu Tai; Mitsuyoshi Urashima; S Shirahama; M Matsuzaki; Dharminder Chauhan; Steve P Treon; Noopur Raje; Teru Hideshima; Y Shima; Kenneth C Anderson
CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines.
Blood 2000;95(3):1039-46.
1999: Yu-Tzu Tai; T Strobel; Donald Kufe; Stephen A Cannistra
In vivo cytotoxicity of ovarian cancer cells through tumor-selective expression of the BAX gene.
Cancer research 1999;59(9):2121-6.
1999: Dharminder Chauhan; Teru Hideshima; Steve P Treon; G Teoh; Noopur Raje; S Yoshihimito; Yu-Tzu Tai; W Li; J Fan; James A DeCaprio; Kenneth C Anderson
Functional interaction between retinoblastoma protein and stress-activated protein kinase in multiple myeloma cells.
Cancer research 1999;59(6):1192-5.
1998: G Teoh; L Chen; Mitsuyoshi Urashima; Yu-Tzu Tai; L A Celi; D Chen; Dharminder Chauhan; A Ogata; Robert W Finberg; Iain Webb; Donald Kufe; Kenneth C Anderson
Adenovirus vector-based purging of multiple myeloma cells.
Blood 1998;92(12):4591-601.
1998: T Strobel; Yu-Tzu Tai; S Korsmeyer; Stephen A Cannistra
BAD partly reverses paclitaxel resistance in human ovarian cancer cells.
Oncogene 1998;17(19):2419-27.
1998: Yu-Tzu Tai; Sandra Lee; E Niloff; CARLA WEISMAN; T Strobel; Stephen A Cannistra
BAX protein expression and clinical outcome in epithelial ovarian cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1998;16(8):2583-90.