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John Tainer

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TOP 3
Robert P Rambo; John A Tainer
Super-resolution in solution x-ray scattering and its applications to structural systems biology.
Robert P Rambo; John A Tainer
Accurate assessment of mass, models and resolution by small-angle scattering.
Sophia Reindl; Gareth J Williams; Sonja-Verena Albers; Abhrajyoti Ghosh; Anna-Lena Henche; Kerstin Lassak; Tomasz Neiner; John A Tainer
Insights into FlaI functions in archaeal motor assembly and motility from structures, conformations, and genetics.

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All Publications

2013: Robert P Rambo; John A Tainer
Super-resolution in solution x-ray scattering and its applications to structural systems biology.
Annual review of biophysics 2013;42():415-41.
2013: Robert P Rambo; John A Tainer
Accurate assessment of mass, models and resolution by small-angle scattering.
Nature 2013;496(7446):477-81.
2013: Sophia Reindl; Gareth J Williams; Sonja-Verena Albers; Abhrajyoti Ghosh; Anna-Lena Henche; Kerstin Lassak; Tomasz Neiner; John A Tainer
Insights into FlaI functions in archaeal motor assembly and motility from structures, conformations, and genetics.
Molecular cell 2013;49(6):1069-82.
2013: Susan Tsutakawa; Andrew S Arvai; Richard P Cunningham; Kenneth A Frankel; Kenichi Hitomi; David J Hosfield; Ivaylo N Ivanov; Tadahide Izumi; Buddhadev Maiti; Anil K Mantha; Sankar Mitra; Clifford D Mol; Mike E Pique; David S Shin; Bartosz Szczesny; John A Tainer
Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes.
The Journal of biological chemistry 2013;288(12):8445-55.
2013: J Jefferson P Perry; John A Tainer
Developing advanced X-ray scattering methods combined with crystallography and computation.
Methods (San Diego, Calif.) 2013;59(3):363-71.
2013: Brandi L Mahaney; Katheryn Meek; John A Tainer; Michal Hammel; Susan P Lees-Miller
XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2013;91(1):31-41.
2013: Chris A Brosey; William T Heller; Ivaylo Ivanov; Robert P Rambo; John A Tainer; Susan Tsutakawa; Chunli Yan; Walter J Chazin
A new structural framework for integrating replication protein A into DNA processing machinery.
Nucleic acids research 2013;41(4):2313-27.
2013: Bjørn Dalhus; Rune Johansen Forstrøm; Joy Huffman; Hanne Korvald; Cynthia T McMurray; Line Nilsen; John A Tainer; Ingrun Alseth; Magnar Bjørås
Sculpting of DNA at abasic sites by DNA glycosylase homolog mag2.
Structure (London, England : 1993) 2013;21(1):154-66.
2012: Ke Shi; John A Tainer; Susan E Tsutakawa; Rui Gao; Kayo Kurahashi; Yves Pommier; Hideki Aihara
Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2.
Nature structural & molecular biology 2012;19(12):1372-7.
2012: Oliver Limbo; davide moiani; John A Tainer; Claire Wyman; Aryandi Kertokalio; Paul Russell
Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair.
Nucleic acids research 2012;40(22):11435-49.
2012: Oliver J Wilkinson; Hannah Blackburn; Bernard A Connolly; Jane A Grasby; Christopher A Hunter; Vitaly Latypov; Geoffrey P Margison; Andrew Marriott; Ryoji Masui; Gail McGown; Christopher L Millington; Rihito Morita; John A Tainer; Mary Thorncroft; Julie L Tubbs; Amanda J Watson; David M Williams
Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(46):18755-60.
2012: Athira Omanakuttan; Nanjan Pandurangan; J Jefferson P Perry; John A Tainer; Rebu K Varghese; Asoke Banerji; Chinchu Bose; Rodney M Harris; Geetha B Kumar; Jyotsna Nambiar; Bipin G Nair
Anacardic acid inhibits the catalytic activity of matrix metalloproteinase-2 and matrix metalloproteinase-9.
Molecular pharmacology 2012;82(4):614-22.
2012: Ka Cheong Lee; davide moiani; Nicholas J Morris; Kay Padget; Zbyslaw Sondka; John A Tainer; Simon J Cockell; Ian G Cowell; Hannah Curtis; Graham H Jackson; Caroline A Austin
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA.
Biology open 2012;1(9):863-73.
2012: Vitaly F Latypov; Andrew S Arvai; Amna Butt; Andrew S Marriott; Gail McGown; Christopher L Millington; Andrew C Povey; Mauro F Santibanez-Koref; Pattama Senthong; John A Tainer; Mary R Thorncroft; Julie L Tubbs; Amanda J Watson; Oliver J Wilkinson; David M Williams; Geoffrey P Margison
Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines.
Molecular cell 2012;47(1):50-60.
2012: Victoria A Roberts; Geir Slupphaug; John A Tainer; Lynn F Ten Eyck; Simon Hsu; Jonathan W Jamison; Jun H Lee; Sheng Li; Tong Liu; Michael E Pique; Robert P Rambo; Virgil L Woods
Combining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase.
Nucleic acids research 2012;40(13):6070-81.
2012: John M Christie; Andrew S Arvai; Kimberly A Hartfield; Kenichi Hitomi; Marcel Mettlen; Ashley J Pratt; John A Tainer; Elizabeth D Getzoff
Structural tuning of the fluorescent protein iLOV for improved photostability.
The Journal of biological chemistry 2012;287(26):22295-304.
2012: In-Kwon Kim; Roderick A Stegeman; John A Tainer; Scott Classen; Chris M W Ho; James R Kiefer; Tom Ellenberger
Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element.
Nature structural & molecular biology 2012;19(6):653-6.
2012: Jordi Querol-Audí; John A Tainer; Miaw-Sheue Tsai; Susan Tsutakawa; Xiaojun Xu; Chunli Yan; Priscilla K Cooper; Eva Nogales; Ivaylo Ivanov
Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(22):8528-33.
2012: Atsushi Yamagata; Lisa Craig; Ekaterina Milgotina; Karen Scanlon; John A Tainer; Michael S Donnenberg
Structure of an essential type IV pilus biogenesis protein provides insights into pilus and type II secretion systems.
Journal of molecular biology 2012;419(1-2):110-24.
2012: Nikesh Patel; John A Tainer; Peter Thompson; Susan Tsutakawa; David M Williams; John M Atack; Jack C Exell; L David Finger; Jane A Grasby
Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends.
Nucleic acids research 2012;40(10):4507-19.
2012: Vincent J B Ruigrok; Hauke Smidt; Regina Stoltenburg; Beate Strehlitz; John A Tainer; Arjan Barendregt; Kevin Dyer; Mark Levisson; Esther van Duijn; John van der Oost
Kinetic and stoichiometric characterisation of streptavidin-binding aptamers.
Chembiochem : a European journal of chemical biology 2012;13(6):829-36.
2012: Kenichi Hitomi; Shigenori Iwai; John A Tainer; Mika Teranishi; Junpei Yamamoto; Kazuo Yamamoto; Andrew S Arvai; Jun Hidema; Tokuhisa Hirouchi; Chiharu Hitomi; Elizabeth D Getzoff
Eukaryotic class II cyclobutane pyrimidine dimer photolyase structure reveals basis for improved ultraviolet tolerance in plants.
The Journal of biological chemistry 2012;287(15):12060-9.
2012: Susan Tsutakawa; John A Tainer
Double strand binding-single strand incision mechanism for human flap endonuclease: implications for the superfamily.
Mechanisms of ageing and development 2012;133(4):195-202.
2012: Pamela A Sontz; John A Tainer; Jill O Fuss; Timothy P Mui; Jacqueline K Barton
DNA charge transport as a first step in coordinating the detection of lesions by repair proteins.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(6):1856-61.
2012: Steven M Yannone; Michael W W Adams; Sophia Hartung; Angeli L Menon; John A Tainer
Metals in biology: defining metalloproteomes.
Current opinion in biotechnology 2012;23(1):89-95.
2012: Jane A Grasby; John M Atack; L David Finger; Susan Tsutakawa; John A Tainer
Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases.
Trends in biochemical sciences 2012;37(2):74-84.
2011: Susan E Tsutakawa; Adam W Van Wynsberghe; M Todd Washington; Christopher P Weinacht; Zhihao Zhuang; Bret D Freudenthal; Lokesh Gakhar; John A Tainer; Ivaylo Ivanov
Solution X-ray scattering combined with computational modeling reveals multiple conformations of covalently bound ubiquitin on PCNA.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(43):17672-7.
2011: Timothy P Mui; John A Tainer; Jill O Fuss; Justin P Ishida; Jacqueline K Barton
ATP-stimulated, DNA-mediated redox signaling by XPD, a DNA repair and transcription helicase.
Journal of the American Chemical Society 2011;133(41):16378-81.
2011: Michal Hammel; Susan P Lees-Miller; Mona Liu; Brandi L Mahaney; Rajam S Mani; Michael E Pique; Martial Rey; David C Schriemer; Scott Classen; Shujuan Fang; Michael Weinfeld; Yaping Yu; John A Tainer
XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair.
The Journal of biological chemistry 2011;286(37):32638-50.
2011: Christopher G Tomlinson; Nicholas H Williams; John M Atack; Jon Sayers; Blanka Sengerová; Linda Swanson; Karl Syson; John A Tainer; Jane A Grasby
Neutralizing mutations of carboxylates that bind metal 2 in T5 flap endonuclease result in an enzyme that still requires two metal ions.
The Journal of biological chemistry 2011;286(35):30878-87.
2011: Robert P Rambo; John A Tainer
Characterizing flexible and intrinsically unstructured biological macromolecules by SAS using the Porod-Debye law.
Biopolymers 2011;95(8):559-71.
2011: Jill Fuss; John A Tainer
XPB and XPD helicases in TFIIH orchestrate DNA duplex opening and damage verification to coordinate repair with transcription and cell cycle via CAK kinase.
DNA repair 2011;10(7):697-713.
2011: Abhrajyoti Ghosh; Sophia Hartung; John A Tainer; chris van der does; Sonja-Verena Albers
Archaeal flagellar ATPase motor shows ATP-dependent hexameric assembly and activity stimulation by specific lipid binding.
The Biochemical journal 2011;437(1):43-52.
2011: Kelly S Trego; Miaw-Sheue Tsai; Steven M Yannone; Judith Campisi; Sophia B Chernikova; Albert R Davalos; L David Finger; Cliff Ng; J Jefferson P Perry; John A Tainer; Priscilla K Cooper
The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome.
Cell cycle (Georgetown, Tex.) 2011;10(12):1998-2007.
2011: Julie L Tubbs; John A Tainer
P53 conformational switching for selectivity may reveal a general solution for specific DNA binding.
The EMBO journal 2011;30(11):2099-100.
2011: Alexei V Kazantsev; Robert P Rambo; Sina Karimpour; John SantaLucia; John A Tainer; Norman R Pace
Solution structure of RNase P RNA.
RNA (New York, N.Y.) 2011;17(6):1159-71.
2011: John Prudden; J Jefferson P Perry; Minghua Nie; Ajay A Vashisht; Andrew S Arvai; Chiharu Hitomi; Grant Guenther; James Wohlschlegel; John A Tainer; Michael N Boddy
DNA repair and global sumoylation are regulated by distinct Ubc9 noncovalent complexes.
Molecular and cellular biology 2011;31(11):2299-310.
2011: David C Arthur; Ross A Edwards; Susan Tsutakawa; John A Tainer; Laura S Frost; J N Mark Glover
Mapping interactions between the RNA chaperone FinO and its RNA targets.
Nucleic acids research 2011;39(10):4450-63.
2011: Susan Tsutakawa; Scott Classen; Brian R Chapados; Andrew S Arvai; L David Finger; Grant Guenther; Christopher G Tomlinson; Peter Thompson; Altaf H Sarker; Binghui Shen; Priscilla K Cooper; Jane A Grasby; John A Tainer
Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily.
Cell 2011;145(2):198-211.
2011: Gareth J Williams; R Scott Williams; Jessica S Williams; Gabriel Moncalian; Andrew S Arvai; Oliver Limbo; Grant Guenther; Soumita SilDas; Michal Hammel; Paul Russell; John A Tainer
ABC ATPase signature helices in Rad50 link nucleotide state to Mre11 interface for DNA repair.
Nature structural & molecular biology 2011;18(4):423-31.
2011: Johanna Heideker; John Prudden; J Jefferson P Perry; John A Tainer; Michael N Boddy
SUMO-targeted ubiquitin ligase, Rad60, and Nse2 SUMO ligase suppress spontaneous Top1-mediated DNA damage and genome instability.
PLoS genetics 2011;7(3):e1001320.
2011: Nathanael G Lintner; Kenneth A Frankel; Susan E Tsutakawa; Donald L Alsbury; Valérie Copié; Mark J Young; John A Tainer; C Martin Lawrence
The structure of the CRISPR-associated protein Csa3 provides insight into the regulation of the CRISPR/Cas system.
Journal of molecular biology 2011;405(4):939-55.
2011: J Jefferson P Perry; John A Tainer
All stressed out without ATM kinase.
Science signaling 2011;4(167):pe18.
2011: W Andrew Lancaster; Jeremy L Praissman; Farris L Poole; Aleksandar Cvetkovic; Angeli Lal Menon; Joseph W Scott; Francis E Jenney; Michael P Thorgersen; Ewa Kalisiak; Junefredo V Apon; Sunia A Trauger; Gary Siuzdak; John A Tainer; Michael W W Adams
A computational framework for proteome-wide pursuit and prediction of metalloproteins using ICP-MS and MS/MS data.
BMC bioinformatics 2011;12():64.
2010: Gareth J Williams; Susan Lees-Miller; John A Tainer
Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks.
DNA repair 2010;9(12):1299-306.
2010: Tracey A Dobbs; John A Tainer; Susan Lees-Miller
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation.
DNA repair 2010;9(12):1307-14.
2010: Robert P Rambo; Gareth J Williams; John A Tainer
Achieving fidelity in homologous recombination despite extreme complexity: informed decisions by molecular profiling.
Molecular cell 2010;40(3):347-8.
2010: Michal Hammel; Yaping Yu; Shujuan Fang; Susan P Lees-Miller; John A Tainer
XLF regulates filament architecture of the XRCC4·ligase IV complex.
Structure (London, England : 1993) 2010;18(11):1431-42.
2010: Scott Classen; Ivan Rodic; James Holton; Greg L Hura; Michal Hammel; John A Tainer
Software for the high-throughput collection of SAXS data using an enhanced Blu-Ice/DCS control system.
Journal of synchrotron radiation 2010;17(6):774-81.
2010: Julie L Tubbs; John A Tainer
Alkyltransferase-like proteins: molecular switches between DNA repair pathways.
Cellular and molecular life sciences : CMLS 2010;67(22):3749-62.
2010: Robin J Rosenfeld; Joseph Bonaventura; Blair R Szymczyna; Michael J MacCoss; Andrew S Arvai; John R Yates; John A Tainer; Elizabeth D Getzoff
Nitric-oxide synthase forms N-NO-pterin and S-NO-cys: implications for activity, allostery, and regulation.
The Journal of biological chemistry 2010;285(41):31581-9.
2010: J Jefferson P Perry; Aroumougame Asaithamby; Adam Barnebey; Foad Kiamanesch; David J Chen; Seungil Han; John A Tainer; Steven M Yannone
Identification of a coiled coil in werner syndrome protein that facilitates multimerization and promotes exonuclease processivity.
The Journal of biological chemistry 2010;285(33):25699-707.
2010: Aleksandar Cvetkovic; Angeli Lal Menon; Michael P Thorgersen; Joseph W Scott; Farris L Poole; Francis E Jenney; W Andrew Lancaster; Jeremy L Praissman; Saratchandra Shanmukh; Brian J Vaccaro; Sunia A Trauger; Ewa Kalisiak; Junefredo V Apon; Gary Siuzdak; Steven M Yannone; John A Tainer; Michael W W Adams
Microbial metalloproteomes are largely uncharacterized.
Nature 2010;466(7307):779-82.
2010: Mindy S Lim; Dixon Ng; ZuSheng Zong; Andrew S Arvai; Ronald K Taylor; John A Tainer; Lisa Craig
Vibrio cholerae El Tor TcpA crystal structure and mechanism for pilus-mediated microcolony formation.
Molecular microbiology 2010;77(3):755-70.
2010: Elizabeth Cotner-Gohara; In-Kwon Kim; Michal Hammel; John A Tainer; Alan E Tomkinson; Tom Ellenberger
Human DNA ligase III recognizes DNA ends by dynamic switching between two DNA-bound states.
Biochemistry 2010;49(29):6165-76.
2010: Elias A Rahal; Leigh A Henricksen; Yuling Li; R Scott Williams; John A Tainer; Kathleen Dixon
ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.
Cell cycle (Georgetown, Tex.) 2010;9(14):2866-77.
2010: John A Tainer; J Andrew McCammon; Ivaylo Ivanov
Recognition of the ring-opened state of proliferating cell nuclear antigen by replication factor C promotes eukaryotic clamp-loading.
Journal of the American Chemical Society 2010;132(21):7372-8.
2010: J Jefferson P Perry; Elizabeth Cotner-Gohara; Tom Ellenberger; John A Tainer
Structural dynamics in DNA damage signaling and repair.
Current opinion in structural biology 2010;20(3):283-94.
2010: James M Aramini; Julie L Tubbs; Sreenivas Kanugula; Paolo Rossi; Asli Ertekin; Melissa Maglaqui; Keith Hamilton; Colleen T Ciccosanti; Mei Jiang; Rong Xiao; Ta-Tsen Soong; Burkhard Rost; Thomas B Acton; John K Everett; Anthony E Pegg; John A Tainer; Gaetano T Montelione
Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein.
The Journal of biological chemistry 2010;285(18):13736-41.
2010: Dalyir I Pretto; Susan Tsutakawa; Chris A Brosey; Amalchi Castillo; Marie-Eve Chagot; Jarrod A Smith; John A Tainer; Walter J Chazin
Structural dynamics and single-stranded DNA binding activity of the three N-terminal domains of the large subunit of replication protein A from small angle X-ray scattering.
Biochemistry 2010;49(13):2880-9.
2010: Christopher G Tomlinson; John M Atack; Brian Chapados; John A Tainer; Jane A Grasby
Substrate recognition and catalysis by flap endonucleases and related enzymes.
Biochemical Society transactions 2010;38(2):433-7.
2010: Jessica S Williams; R Scott Williams; Claire L Dovey; Grant Guenther; John A Tainer; Paul Russell
gammaH2A binds Brc1 to maintain genome integrity during S-phase.
The EMBO journal 2010;29(6):1136-48.
2010: Qingming Fang; Sreenivas Kanugula; Julie L Tubbs; John A Tainer; Anthony E Pegg
Repair of O4-alkylthymine by O6-alkylguanine-DNA alkyltransferases.
The Journal of biological chemistry 2010;285(11):8185-95.
2010: Robert P Rambo; John A Tainer
Improving small-angle X-ray scattering data for structural analyses of the RNA world.
RNA (New York, N.Y.) 2010;16(3):638-46.
2010: Robert P Rambo; John A Tainer
Bridging the solution divide: comprehensive structural analyses of dynamic RNA, DNA, and protein assemblies by small-angle X-ray scattering.
Current opinion in structural biology 2010;20(1):128-37.
2010: Michal Hammel; Yaping Yu; Brandi L Mahaney; Brandon Cai; Ruiqiong Ye; Barry M Phipps; Robert P Rambo; Greg L Hura; Martin Pelikan; Sairei So; Ramin M Abolfath; David J Chen; Susan P Lees-Miller; John A Tainer
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.
The Journal of biological chemistry 2010;285(2):1414-23.
2010: Sayo Kashiwagi; Isao Kuraoka; Yoshie Fujiwara; Kenichi Hitomi; Quen J Cheng; Jill O Fuss; David S Shin; Chikahide Masutani; John A Tainer; Fumio Hanaoka; Shigenori Iwai
Characterization of a Y-Family DNA Polymerase eta from the Eukaryotic Thermophile Alvinella pompejana.
Journal of nucleic acids 2010;2010():.
2010: J Jefferson P Perry; David S Shin; John A Tainer
Amyotrophic lateral sclerosis.
Advances in experimental medicine and biology 2010;685():9-20.
2009: Alexander E Aleshin; Svetlana Gramatikova; Gregory L Hura; Andrey Bobkov; Alex Y Strongin; Boguslaw Stec; John A Tainer; Robert C Liddington; Jeffrey W Smith
Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case.
Structure (London, England : 1993) 2009;17(11):1465-75.
2009: R Scott Williams; Gerald E Dodson; Oliver Limbo; Yoshiki Yamada; Jessica S Williams; Grant Guenther; Scott Classen; J N Mark Glover; Hiroshi Iwasaki; Paul Russell; John A Tainer
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.
Cell 2009;139(1):87-99.
2009: Nina K Bernstein; M Hammel; Rajam S Mani; Michael Weinfeld; M Pelikan; John A Tainer; J N Mark Glover
Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase.
Nucleic acids research 2009;37(18):6161-73.
2009: J Jefferson P Perry; Rodney M Harris; davide moiani; Arthur J Olson; John A Tainer
p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses.
Journal of molecular biology 2009;391(1):1-11.
2009: Greg L Hura; Angeli L Menon; Michal Hammel; Robert P Rambo; Farris L Poole; Susan Tsutakawa; Francis E Jenney; Scott Classen; Ken Frankel; Robert C Hopkins; Sung-Jae Yang; Joseph W Scott; Bret D Dillard; Michael W W Adams; John A Tainer
Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS).
Nature methods 2009;6(8):606-12.
2009: Julie L Tubbs; Vitaly Latypov; Sreenivas Kanugula; Amna Butt; Manana Melikishvili; Rolf Kraehenbuehl; Oliver Fleck; Andrew Marriott; Amanda J Watson; Barbara Verbeek; Gail McGown; Mary Thorncroft; Mauro F Santibanez-Koref; Christopher Millington; Andrew S Arvai; Matthew D Kroeger; Lisa A Peterson; David M Williams; Michael G Fried; Geoffrey P Margison; Anthony E Pegg; John A Tainer
Flipping of alkylated DNA damage bridges base and nucleotide excision repair.
Nature 2009;459(7248):808-13.
2009: J Jefferson P Perry; Kenichi Hitomi; John A Tainer
Flexibility promotes fidelity.
Structure (London, England : 1993) 2009;17(5):633-4.
2009: John Prudden; J Jefferson P Perry; Andrew S Arvai; John A Tainer; Michael N Boddy
Molecular mimicry of SUMO promotes DNA repair.
Nature structural & molecular biology 2009;16(5):509-16.
2009: Kenichi Hitomi; Luciano DiTacchio; Andrew S Arvai; Junpei Yamamoto; Sang-Tae Kim; Takeshi Todo; John A Tainer; Shigenori Iwai; Satchidananda Panda; Elizabeth D Getzoff
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):6962-7.
2009: J Jefferson P Perry; Amy S Hearn; Diane E Cabelli; Harry S Nick; John A Tainer; David N Silverman
Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.
Biochemistry 2009;48(15):3417-24.
2009: David S Shin; Michael DiDonato; David P Barondeau; Greg L Hura; Chiharu Hitomi; J Andrew Berglund; Elizabeth D Getzoff; S Craig Cary; John A Tainer
Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis.
Journal of molecular biology 2009;385(5):1534-55.
2009: Bjørn Dalhus; Andrew S Arvai; Ida Rosnes; Øyvind E Olsen; Paul H Backe; Ingrun Alseth; Honghai Gao; Weiguo Cao; John A Tainer; Magnar Bjørås
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair.
Nature structural & molecular biology 2009;16(2):138-43.
2009: Xiaoshan Min; Radha Akella; Haixia He; John M Humphreys; Susan Tsutakawa; Seung-Jae Lee; John A Tainer; Melanie H Cobb; Elizabeth J Goldsmith
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer.
Structure (London, England : 1993) 2009;17(1):96-104.
2008: R Scott Williams; Gareth Williams; John A Tainer
A charged performance by gp17 in viral packaging.
Cell 2008;135(7):1169-71.
2008: Ross A Edwards; Megan S Lee; Susan Tsutakawa; R Scott Williams; I Nazeer; F E Kleiman; John A Tainer; J N Mark Glover
The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.
Biochemistry 2008;47(44):11446-56.
2008: Elsa D Garcin; Andrew S Arvai; Robin J Rosenfeld; Matt D Kroeger; Brian R Crane; Gunilla Andersson; Glen Andrews; Peter J Hamley; Philip R Mallinder; David J Nicholls; Stephen A St-Gallay; Alan C Tinker; Nigel P Gensmantel; Antonio Mete; David R Cheshire; Stephen Connolly; Dennis J Stuehr; Anders Aberg; Alan V Wallace; John A Tainer; Elizabeth D Getzoff
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nature chemical biology 2008;4(11):700-7.
2008: Karl Syson; Christopher Tomlinson; Brian R Chapados; Jon Sayers; John A Tainer; Nicholas H Williams; Jane A Grasby
Three metal ions participate in the reaction catalyzed by T5 flap endonuclease.
The Journal of biological chemistry 2008;283(42):28741-6.
2008: Qingming Fang; Anne M Noronha; Sebastian P Murphy; Christopher J Wilds; Julie L Tubbs; John A Tainer; Goutam Chowdhury; F Peter Guengerich; Anthony E Pegg
Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.
Biochemistry 2008;47(41):10892-903.
2008: R Scott Williams; Gabriel Moncalian; Jessica S Williams; Yoshiki Yamada; Oliver Limbo; David S Shin; Lynda M Groocock; Dana Cahill; Chiharu Hitomi; Grant Guenther; davide moiani; James P Carney; Paul Russell; John A Tainer
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Cell 2008;135(1):97-109.
2008: Stephanie Pebernard; J Jefferson P Perry; John A Tainer; Michael N Boddy
Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.
Molecular biology of the cell 2008;19(10):4099-109.
2008: Jill E Chrencik; Alexei Brooun; Hui Zhang; Irimpan I Mathews; Greg L Hura; Scott A Foster; J Jefferson P Perry; Markus B Streiff; Paul Ramage; Hans Widmer; Gary M Bokoch; John A Tainer; Gisbert Weckbecker; Peter Kuhn
Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.
Journal of molecular biology 2008;380(5):828-43.
2008: Li Fan; Jill Fuss; Quen J Cheng; Andrew S Arvai; Michal Hammel; Victoria A Roberts; Priscilla K Cooper; John A Tainer
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
Cell 2008;133(5):789-800.
2008: Elsa D Garcin; David J Hosfield; Brenda Osborne; Brian J Haas; Magnar Björas; Richard P Cunningham; John A Tainer
DNA apurinic-apyrimidinic site binding and excision by endonuclease IV.
Nature structural & molecular biology 2008;15(5):515-22.
2008: J Jefferson P Perry; John A Tainer; Michael N Boddy
A SIM-ultaneous role for SUMO and ubiquitin.
Trends in biochemical sciences 2008;33(5):201-8.
2007: Blaine R Roberts; John A Tainer; Elizabeth D Getzoff; Dean A Malencik; Sonia R Anderson; Valerie C Bomben; Kathrin R Meyers; P Andrew Karplus; Joseph S Beckman
Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS.
Journal of molecular biology 2007;373(4):877-90.
2007: John Prudden; Stephanie Pebernard; Grazia D Raffa; Daniela A Slavin; J Jefferson P Perry; John A Tainer; Clare H McGowan; Michael N Boddy
SUMO-targeted ubiquitin ligases in genome stability.
The EMBO journal 2007;26(18):4089-101.
2007: Ryan Williams; Blanka Sengerová; Sadie Osborne; Karl Syson; Sophie Ault; Anna Kilgour; Brian R Chapados; John A Tainer; Jon Sayers; Jane A Grasby
Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease.
Journal of molecular biology 2007;371(1):34-48.
2007: Christopher D Putnam; Michal Hammel; Greg L Hura; John A Tainer
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution.
Quarterly reviews of biophysics 2007;40(3):191-285.
2007: R Scott Williams; Jessica S Williams; John A Tainer
Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2007;85(4):509-20.
2007: Julie L Tubbs; Anthony E Pegg; John A Tainer
DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy.
DNA repair 2007;6(8):1100-15.
2007: Susan Tsutakawa; Greg L Hura; Ken Frankel; Priscilla K Cooper; John A Tainer
Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography.
Journal of structural biology 2007;158(2):214-23.
2007: Kenichi Hitomi; Shigenori Iwai; John A Tainer
The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair.
DNA repair 2007;6(4):410-28.
2007: R Scott Williams; John A Tainer
Learning our ABCs: Rad50 directs MRN repair functions via adenylate kinase activity from the conserved ATP binding cassette.
Molecular cell 2007;25(6):789-91.
2007: David P Barondeau; Carey J Kassmann; John A Tainer; Elizabeth D Getzoff
The case of the missing ring: radical cleavage of a carbon-carbon bond and implications for GFP chromophore biosynthesis.
Journal of the American Chemical Society 2007;129(11):3118-26.
2007: Atsushi Yamagata; John A Tainer
Hexameric structures of the archaeal secretion ATPase GspE and implications for a universal secretion mechanism.
The EMBO journal 2007;26(3):878-90.
2007: Ivaylo Ivanov; John A Tainer; J Andrew McCammon
Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1465-70.
2007: Sangeetha Vijayakumar; Brian R Chapados; Kristina H Schmidt; Richard D Kolodner; John A Tainer; Alan E Tomkinson
The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase.
Nucleic acids research 2007;35(5):1624-37.
2006: John Pascal; Oleg V Tsodikov; Greg L Hura; Wei Song; Elizabeth A Cotner; Scott Classen; Alan E Tomkinson; John A Tainer; Tom Ellenberger
A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.
Molecular cell 2006;24(2):279-91.
2006: Lisa Craig; Niels Volkmann; Andrew S Arvai; Michael E Pique; Mark Yeager; Edward H Egelman; John A Tainer
Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions.
Molecular cell 2006;23(5):651-62.
2006: Ottar Sundheim; Cathrine B Vågbø; Magnar Bjørås; Mirta M L Sousa; Vivi Talstad; Per Arne Aas; Finn Drabløs; Hans E Krokan; John A Tainer; Geir Slupphaug
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
The EMBO journal 2006;25(14):3389-97.
2006: Li Fan; Sangbumn Kim; Carol L Farr; Kevin T Schaefer; Kathleen M Randolph; John A Tainer; Laurie S Kaguni
A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase.
Journal of molecular biology 2006;358(5):1229-43.
2006: J Jefferson P Perry; Steven M Yannone; Lauren G Holden; Chiharu Hitomi; Aroumougame Asaithamby; Seungil Han; Priscilla K Cooper; David J Chen; John A Tainer
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.
Nature structural & molecular biology 2006;13(5):414-22.
2006: David P Barondeau; Carey J Kassmann; John A Tainer; Elizabeth D Getzoff
Understanding GFP posttranslational chemistry: structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation.
Journal of the American Chemical Society 2006;128(14):4685-93.
2006: Li Fan; Andrew S Arvai; Priscilla K Cooper; Shigenori Iwai; Fumio Hanaoka; John A Tainer
Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair.
Molecular cell 2006;22(1):27-37.
2006: David P Barondeau; John A Tainer; Elizabeth D Getzoff
Structural evidence for an enolate intermediate in GFP fluorophore biosynthesis.
Journal of the American Chemical Society 2006;128(10):3166-8.
2006: Ivaylo Ivanov; Brian R Chapados; J Andrew McCammon; John A Tainer
Proliferating cell nuclear antigen loaded onto double-stranded DNA: dynamics, minor groove interactions and functional implications.
Nucleic acids research 2006;34(20):6023-33.
2006: Yusuke Doi; Atsushi Katafuchi; Yoshie Fujiwara; Kenichi Hitomi; John A Tainer; Hiroshi Ide; Shigenori Iwai
Synthesis and characterization of oligonucleotides containing 2'-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction.
Nucleic acids research 2006;34(5):1540-51.
2005: Timothy I Wood; David P Barondeau; Chiharu Hitomi; Carey J Kassmann; John A Tainer; Elizabeth D Getzoff
Defining the role of arginine 96 in green fluorescent protein fluorophore biosynthesis.
Biochemistry 2005;44(49):16211-20.
2005: Christopher D Putnam; John A Tainer
Protein mimicry of DNA and pathway regulation.
DNA repair 2005;4(12):1410-20.
2005: Patricia Ayala; J Scott Wilbur; Wetzler Lee; John A Tainer; Aurelie Snyder; Magdalene So
The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca(2+) transients in infected epithelial cells.
Cellular microbiology 2005;7(12):1736-48.
2005: Idelisa Ayala; J Jefferson P Perry; Jan Szczepanski; John A Tainer; Martin T Vala; Harry S Nick; David N Silverman
Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine.
Biophysical journal 2005;89(6):4171-9.
2005: Altaf H Sarker; Susan Tsutakawa; Seth Kostek; Cliff Ng; David S Shin; Marian Peris; Eric Campeau; John A Tainer; Eva Nogales; Priscilla K Cooper
Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome.
Molecular cell 2005;20(2):187-98.
2005: R Scott Williams; John A Tainer
A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks.
Molecular cell 2005;19(6):724-6.
2005: Federica Simeoni; Andrew S Arvai; Paul Bello; Claire Gondeau; Karl-Peter Hopfner; Paolo Neyroz; Frédéric Heitz; John A Tainer; Gilles Divita
Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2.
Biochemistry 2005;44(36):11997-2008.
2005: Joy L Huffman; Ottar Sundheim; John A Tainer
DNA base damage recognition and removal: new twists and grooves.
Mutation research 2005;577(1-2):55-76.
2005: Julie L Tubbs; John A Tainer; Elizabeth D Getzoff
Crystallographic structures of Discosoma red fluorescent protein with immature and mature chromophores: linking peptide bond trans-cis isomerization and acylimine formation in chromophore maturation.
Biochemistry 2005;44(29):9833-40.
2005: Lynette J Crowther; Atsushi Yamagata; Lisa Craig; John A Tainer; Michael S Donnenberg
The ATPase activity of BfpD is greatly enhanced by zinc and allosteric interactions with other Bfp proteins.
The Journal of biological chemistry 2005;280(26):24839-48.
2005: David P Barondeau; Carey J Kassmann; John A Tainer; Elizabeth D Getzoff
Understanding GFP chromophore biosynthesis: controlling backbone cyclization and modifying post-translational chemistry.
Biochemistry 2005;44(6):1960-70.
2005: Yusuke Doi; Kenichi Hitomi; John A Tainer; Shigenori Iwai
Synthesis of oligonucleotides containing 2'-fluorinated thymidine glycol as mechanism-based inhibitors of endonuclease III.
Nucleic acids symposium series (2004) 2005;(49):195-6.
2004: Raymond C Manuel; Kenichi Hitomi; Andrew S Arvai; Paul G House; Andrew J Kurtz; ML Dodson; Amanda K McCullough; John A Tainer; R Stephen Lloyd
Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase.
The Journal of biological chemistry 2004;279(45):46930-9.
2004: Elsa D Garcin; Christopher M Bruns; Sarah J Lloyd; David J Hosfield; Mauro Tiso; Ratan Gachhui; Dennis J Stuehr; John A Tainer; Elizabeth D Getzoff
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.
The Journal of biological chemistry 2004;279(36):37918-27.
2004: David S Shin; Charly Chahwan; Joy L Huffman; John A Tainer
Structure and function of the double-strand break repair machinery.
DNA repair 2004;3(8-9):863-73.
2004: Douglas S Daniels; Tammy T Woo; Kieu X Luu; David M Noll; Neil D Clarke; Anthony E Pegg; John A Tainer
DNA binding and nucleotide flipping by the human DNA repair protein AGT.
Nature structural & molecular biology 2004;11(8):714-20.
2004: David P Barondeau; Carey J Kassmann; Cami K Bruns; John A Tainer; Elizabeth D Getzoff
Nickel superoxide dismutase structure and mechanism.
Biochemistry 2004;43(25):8038-47.
2004: Martijn de Jager; Kelly M Trujillo; Patrick Sung; Karl-Peter Hopfner; James P Carney; John A Tainer; John C Connelly; David R F Leach; Roland Kanaar; Claire Wyman
Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex.
Journal of molecular biology 2004;339(4):937-49.
2004: William B Greenleaf; J Jefferson P Perry; Amy S Hearn; Diane E Cabelli; James R Lepock; M Elizabeth Stroupe; John A Tainer; Harry S Nick; David N Silverman
Role of hydrogen bonding in the active site of human manganese superoxide dismutase.
Biochemistry 2004;43(22):7038-45.
2004: Junzhuan Qiu; Ren Liu; Brian R Chapados; Mark Sherman; John A Tainer; Binghui Shen
Interaction interface of human flap endonuclease-1 with its DNA substrates.
The Journal of biological chemistry 2004;279(23):24394-402.
2004: Stephen Connolly; Anders Aberg; Andrew S Arvai; Haydn G Beaton; David R Cheshire; Anthony R Cook; Sally Cooper; David Cox; Peter Hamley; Phil Mallinder; Ian Millichip; David J Nicholls; Robin J Rosenfeld; Stephen A St-Gallay; John A Tainer; Alan C Tinker; Alan V Wallace
2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.
Journal of medicinal chemistry 2004;47(12):3320-3.
2004: Lisa Craig; Michael E Pique; John A Tainer
Type IV pilus structure and bacterial pathogenicity.
Nature reviews. Microbiology 2004;2(5):363-78.
2004: Amy S Hearn; Li Fan; James R Lepock; James P Luba; William B Greenleaf; Diane E Cabelli; John A Tainer; Harry S Nick; David N Silverman
Amino acid substitution at the dimeric interface of human manganese superoxide dismutase.
The Journal of biological chemistry 2004;279(7):5861-6.
2004: Gabriel Moncalian; Bettina Lengsfeld; Venugopal Bhaskara; Karl-Peter Hopfner; Annette Karcher; Erinn Alden; John A Tainer; Tanya T Paull
The rad50 signature motif: essential to ATP binding and biological function.
Journal of molecular biology 2004;335(4):937-51.
2004: Brian R Chapados; David J Hosfield; Seungil Han; Junzhuan Qiu; Biana Yelent; Binghui Shen; John A Tainer
Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.
Cell 2004;116(1):39-50.
2004: L Matthew Arthur; Karin Gustausson; Karl-Peter Hopfner; Christian T Carson; Travis H Stracker; Annette Karcher; Diana Felton; Matthew D Weitzman; John A Tainer; James P Carney
Structural and functional analysis of Mre11-3.
Nucleic acids research 2004;32(6):1886-93.
2003: David P Barondeau; Christopher D Putnam; Carey J Kassmann; John A Tainer; Elizabeth D Getzoff
Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12111-6.
2003: Michael DiDonato; Lisa Craig; Mary E Huff; Maria M Thayer; Rosa M F Cardoso; Carey J Kassmann; Terence P Lo; Cami K Bruns; Evan T Powers; Jeffery W Kelly; Elizabeth D Getzoff; John A Tainer
ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization.
Journal of molecular biology 2003;332(3):601-15.
2003: David S Shin; Luca Pellegrini; Douglas S Daniels; Biana Yelent; Lisa Craig; Debbie Bates; David S Yu; Mahmud K K Shivji; Chiharu Hitomi; Andrew S Arvai; Niels Volkmann; Hiro Tsuruta; Tom L Blundell; Ashok R Venkitaraman; John A Tainer
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2.
The EMBO journal 2003;22(17):4566-76.
2003: Joy L Huffman; Hong Li; Robert H White; John A Tainer
Structural basis for recognition and catalysis by the bifunctional dCTP deaminase and dUTPase from Methanococcus jannaschii.
Journal of molecular biology 2003;331(4):885-96.
2003: Cynthia T McMurray; John A Tainer
Cancer, cadmium and genome integrity.
Nature genetics 2003;34(3):239-41.
2003: Michael Wang; Joseph M Howell; Jane E Libbey; John A Tainer; Robert S Fujinami
Manganese superoxide dismutase induction during measles virus infection.
Journal of medical virology 2003;70(3):470-4.
2003: Lisa Craig; Ronald K Taylor; Michael E Pique; Brian D Adair; Andrew S Arvai; Mona Singh; Sarah J Lloyd; David S Shin; Elizabeth D Getzoff; Mark Yeager; Katrina T Forest; John A Tainer
Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin.
Molecular cell 2003;11(5):1139-50.
2003: Karl-Peter Hopfner; John A Tainer
Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures.
Current opinion in structural biology 2003;13(2):249-55.
2003: Rosa M F Cardoso; Douglas S Daniels; Christopher M Bruns; John A Tainer
Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum.
Proteins 2003;51(1):137-46.
2003: Amy S Hearn; M Elizabeth Stroupe; Diane E Cabelli; Cecilia A Ramilo; James P Luba; John A Tainer; Harry S Nick; David N Silverman
Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel.
Biochemistry 2003;42(10):2781-9.
2003: Mika Aoyagi; Andrew S Arvai; John A Tainer; Elizabeth D Getzoff
Structural basis for endothelial nitric oxide synthase binding to calmodulin.
The EMBO journal 2003;22(4):766-75.
2003: Ronald Brudler; Kenichi Hitomi; Hiromi Daiyasu; Hiroyuki Toh; Ken-ichi Kucho; Masahiro Ishiura; Minoru Kanehisa; Victoria A Roberts; Takeshi Todo; John A Tainer; Elizabeth D Getzoff
Identification of a new cryptochrome class. Structure, function, and evolution.
Molecular cell 2003;11(1):59-67.
2002: Robin J Rosenfeld; Elsa D Garcin; Koustubh Panda; Gunilla Andersson; Anders Aberg; Alan V Wallace; Garrett M Morris; Arthur J Olson; Dennis J Stuehr; John A Tainer; Elizabeth D Getzoff
Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.
Biochemistry 2002;41(47):13915-25.
2002: Rosa M F Cardoso; Maria M Thayer; Michael DiDonato; Terence P Lo; Cami K Bruns; Elizabeth D Getzoff; John A Tainer
Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase.
Journal of molecular biology 2002;324(2):247-56.
2002: Abdel-Monem Abdalla; Christopher M Bruns; John A Tainer; Bengt Mannervik; Gun Stenberg
Design of a monomeric human glutathione transferase GSTP1, a structurally stable but catalytically inactive protein.
Protein engineering 2002;15(10):827-34.
2002: Karl-Peter Hopfner; Lisa Craig; Gabriel Moncalian; Robert A Zinkel; Takehiko Usui; Barbara A L Owen; Annette Karcher; Brendan Henderson; Jean-Luc Bodmer; Cynthia T McMurray; James P Carney; John H J Petrini; John A Tainer
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair.
Nature 2002;418(6897):562-6.
2002: May C Morris; Claire Gondeau; John A Tainer; Gilles Divita
Kinetic mechanism of activation of the Cdk2/cyclin A complex. Key role of the C-lobe of the Cdk.
The Journal of biological chemistry 2002;277(26):23847-53.
2002: David P Barondeau; Carey J Kassmann; John A Tainer; Elizabeth D Getzoff
Structural chemistry of a green fluorescent protein Zn biosensor.
Journal of the American Chemical Society 2002;124(14):3522-4.
2002: Seungil Han; John A Tainer
The ARTT motif and a unified structural understanding of substrate recognition in ADP-ribosylating bacterial toxins and eukaryotic ADP-ribosyltransferases.
International journal of medical microbiology : IJMM 2002;291(6-7):523-9.
2002: Karl-Peter Hopfner; Christopher D Putnam; John A Tainer
DNA double-strand break repair from head to tail.
Current opinion in structural biology 2002;12(1):115-22.
2002: Clifford D Mol; Andrew S Arvai; Thomas Begley; Richard P Cunningham; John A Tainer
Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases.
Journal of molecular biology 2002;315(3):373-84.
2002: Subrata Adak; Alexandrine M Bilwes; Koustubh Panda; David J Hosfield; kulwant aulak; John F McDonald; John A Tainer; Elizabeth D Getzoff; Brian R Crane; Dennis J Stuehr
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):107-12.
2002: Jesus M Castagnetto; Sean W Hennessy; Victoria A Roberts; Elizabeth D Getzoff; John A Tainer; Michael E Pique
MDB: the Metalloprotein Database and Browser at The Scripps Research Institute.
Nucleic acids research 2002;30(1):379-82.
2001: M Aoyagi; Andrew S Arvai; Sanjay Ghosh; Dennis J Stuehr; John A Tainer; Elizabeth D Getzoff
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Biochemistry 2001;40(43):12826-32.
2001: Amy S Hearn; M Elizabeth Stroupe; Diane E Cabelli; James R Lepock; John A Tainer; Harry S Nick; David N Silverman
Kinetic analysis of product inhibition in human manganese superoxide dismutase.
Biochemistry 2001;40(40):12051-8.
2001: Christopher D Putnam; S B Clancy; Hiro Tsuruta; S Gonzalez; J G Wetmur; John A Tainer
Structure and mechanism of the RuvB Holliday junction branch migration motor.
Journal of molecular biology 2001;311(2):297-310.
2001: Karl-Peter Hopfner; Annette Karcher; Lisa Craig; T T Woo; James P Carney; John A Tainer
Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase.
Cell 2001;105(4):473-85.
2001: B P Ayala; Brandi Vasquez; Susan Clary; John A Tainer; K Rodland; Magdalene So
The pilus-induced Ca2+ flux triggers lysosome exocytosis and increases the amount of Lamp1 accessible to Neisseria IgA1 protease.
Cellular microbiology 2001;3(4):265-75.
2001: Brian R Chapados; Qing Chai; David J Hosfield; Junzhuan Qiu; Binghui Shen; John A Tainer
Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication.
Journal of molecular biology 2001;307(2):541-56.
2001: Seungil Han; Andrew S Arvai; S B Clancy; John A Tainer
Crystal structure and novel recognition motif of rho ADP-ribosylating C3 exoenzyme from Clostridium botulinum: structural insights for recognition specificity and catalysis.
Journal of molecular biology 2001;305(1):95-107.
2001: David J Hosfield; Douglas S Daniels; Clifford D Mol; Christopher D Putnam; SS Parikh; John A Tainer
DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes.
Progress in nucleic acid research and molecular biology 2001;68():315-47.
2000: Karl-Peter Hopfner; John A Tainer
DNA mismatch repair: the hands of a genome guardian.
Structure (London, England : 1993) 2000;8(12):R237-41.
2000: Karl-Peter Hopfner; Annette Karcher; D Shin; C Fairley; John A Tainer; James P Carney
Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine.
Journal of bacteriology 2000;182(21):6036-41.
2000: Clifford D Mol; David J Hosfield; John A Tainer
Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means.
Mutation research 2000;460(3-4):211-29.
2000: SS Parikh; Christopher D Putnam; John A Tainer
Lessons learned from structural results on uracil-DNA glycosylase.
Mutation research 2000;460(3-4):183-99.
2000: Douglas S Daniels; John A Tainer
Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase.
Mutation research 2000;460(3-4):151-63.
2000: Karl-Peter Hopfner; Annette Karcher; David S Shin; Lisa Craig; L Matthew Arthur; James P Carney; John A Tainer
Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily.
Cell 2000;101(7):789-800.
2000: V J Lévêque; M Elizabeth Stroupe; James R Lepock; Diane E Cabelli; John A Tainer; Harry S Nick; David N Silverman
Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis.
Biochemistry 2000;39(24):7131-7.
2000: SS Parikh; G Walcher; G D Jones; Geir Slupphaug; Hans E Krokan; G M Blackburn; John A Tainer
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5083-8.
2000: Brian R Crane; Andrew S Arvai; Sanjay Ghosh; Elizabeth D Getzoff; Dennis J Stuehr; John A Tainer
Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.
Biochemistry 2000;39(16):4608-21.
2000: Douglas S Daniels; Clifford D Mol; Andrew S Arvai; S Kanugula; Anthony E Pegg; John A Tainer
Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.
The EMBO journal 2000;19(7):1719-30.
2000: Christopher D Putnam; Andrew S Arvai; Y Bourne; John A Tainer
Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.
Journal of molecular biology 2000;296(1):295-309.
2000: Karl-Peter Hopfner; SS Parikh; John A Tainer
Envisioning the fourth dimension of the genetic code: the structural biology of macromolecular recognition and conformational switching in DNA repair.
Cold Spring Harbor symposia on quantitative biology 2000;65():113-26.
1999: Brian R Crane; Robin J Rosenfeld; Andrew S Arvai; DK Ghosh; Sanjay Ghosh; John A Tainer; Dennis J Stuehr; Elizabeth D Getzoff
N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.
The EMBO journal 1999;18(22):6271-81.
1999: DK Ghosh; Brian R Crane; Sanjay Ghosh; D Wolan; Ratan Gachhui; C Crooks; A Presta; John A Tainer; Elizabeth D Getzoff; Dennis J Stuehr
Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction.
The EMBO journal 1999;18(22):6260-70.
1999: S Han; J A Craig; Christopher D Putnam; N B Carozzi; John A Tainer
Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex.
Nature structural biology 1999;6(10):932-6.
1999: C A Ramilo; Vincent Leveque; Y Guan; James R Lepock; John A Tainer; Harry S Nick; David N Silverman
Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase.
The Journal of biological chemistry 1999;274(39):27711-6.
1999: Subrata Adak; C Crooks; Qing Wang; Brian R Crane; John A Tainer; Elizabeth D Getzoff; Dennis J Stuehr
Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric oxide feedback inhibition.
The Journal of biological chemistry 1999;274(38):26907-11.
1999: Diane E Cabelli; Y Guan; Vincent Leveque; Amy S Hearn; John A Tainer; Harry S Nick; David N Silverman
Role of tryptophan 161 in catalysis by human manganese superoxide dismutase.
Biochemistry 1999;38(36):11686-92.
1999: Sanjay Ghosh; D Wolan; Subrata Adak; Brian R Crane; N S Kwon; John A Tainer; Elizabeth D Getzoff; Dennis J Stuehr
Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase.
The Journal of biological chemistry 1999;274(34):24100-12.
1999: David J Hosfield; Y Guan; Brian J Haas; Richard P Cunningham; John A Tainer
Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis.
Cell 1999;98(3):397-408.
1999: Jean-Luc Pellequer; S w Chen; Victoria A Roberts; John A Tainer; Elizabeth D Getzoff
Unraveling the effect of changes in conformation and compactness at the antibody V(L)-V(H) interface upon antigen binding.
Journal of molecular recognition : JMR 1999;12(4):267-75.
1999: Christopher M Bruns; Ina Hubatsch; M Ridderström; Bengt Mannervik; John A Tainer
Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products.
Journal of molecular biology 1999;288(3):427-39.
1999: Brian J Haas; Margarita Sandigursky; John A Tainer; William A Franklin; Richard P Cunningham
Purification and characterization of Thermotoga maritima endonuclease IV, a thermostable apurinic/apyrimidinic endonuclease and 3'-repair diesterase.
Journal of bacteriology 1999;181(9):2834-9.
1999: Mary Jane Shroyer; Samuel E Bennett; Christopher D Putnam; John A Tainer; Dale W Mosbaugh
Mutation of an active site residue in Escherichia coli uracil-DNA glycosylase: effect on DNA binding, uracil inhibition and catalysis.
Biochemistry 1999;38(15):4834-45.
1999: Christopher D Putnam; Mary Jane Shroyer; Amy J Lundquist; Clifford D Mol; Andrew S Arvai; Dale W Mosbaugh; John A Tainer
Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase.
Journal of molecular biology 1999;287(2):331-46.
1999: Katrina T Forest; Steven Dunham; Michael Koomey; John A Tainer
Crystallographic structure reveals phosphorylated pilin from Neisseria: phosphoserine sites modify type IV pilus surface chemistry and fibre morphology.
Molecular microbiology 1999;31(3):743-52.
1999: SS Parikh; Clifford D Mol; David J Hosfield; John A Tainer
Envisioning the molecular choreography of DNA base excision repair.
Current opinion in structural biology 1999;9(1):37-47.
1999: Clifford D Mol; SS Parikh; Christopher D Putnam; Terence P Lo; John A Tainer
DNA repair mechanisms for the recognition and removal of damaged DNA bases.
Annual review of biophysics and biomolecular structure 1999;28():101-28.
1998: Y Guan; Raymond C Manuel; Andrew S Arvai; SS Parikh; Clifford D Mol; J H Miller; R Stephen Lloyd; John A Tainer
MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily.
Nature structural biology 1998;5(12):1058-64.
1998: David J Hosfield; G Frank; Y Weng; John A Tainer; Binghui Shen
Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1.
The Journal of biological chemistry 1998;273(42):27154-61.
1998: David J Hosfield; Clifford D Mol; Binghui Shen; John A Tainer
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Cell 1998;95(1):135-46.
1998: SS Parikh; Clifford D Mol; Geir Slupphaug; S Bharati; Hans E Krokan; John A Tainer
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
The EMBO journal 1998;17(17):5214-26.
1998: Binghui Shen; Junzhuan Qiu; D Hosfield; John A Tainer
Flap endonuclease homologs in archaebacteria exist as independent proteins.
Trends in biochemical sciences 1998;23(5):171-3.
1998: Y Hsieh; Y Guan; Chingkuang Tu; P J Bratt; Alexander Angerhofer; James R Lepock; M J Hickey; John A Tainer; Harry S Nick; David N Silverman
Probing the active site of human manganese superoxide dismutase: the role of glutamine 143.
Biochemistry 1998;37(14):4731-9.
1998: Y Guan; M J Hickey; Gloria E. Borgstahl; RA Hallewell; James R Lepock; D O'Connor; Y Hsieh; Harry S Nick; David N Silverman; John A Tainer
Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34.
Biochemistry 1998;37(14):4722-30.
1998: Brian R Crane; Andrew S Arvai; DK Ghosh; Chuanyue Wu; Elizabeth D Getzoff; Dennis J Stuehr; John A Tainer
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Science (New York, N.Y.) 1998;279(5359):2121-6.
1998: Michael Marceau; Katrina T Forest; J L Béretti; John A Tainer; Xavier Nassif
Consequences of the loss of O-linked glycosylation of meningococcal type IV pilin on piliation and pilus-mediated adhesion.
Molecular microbiology 1998;27(4):705-15.
1997: SS Parikh; Clifford D Mol; John A Tainer
Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway.
Structure (London, England : 1993) 1997;5(12):1543-50.
1997: Brian R Crane; Andrew S Arvai; Ratan Gachhui; Chuanyue Wu; DK Ghosh; Elizabeth D Getzoff; Dennis J Stuehr; John A Tainer
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Science (New York, N.Y.) 1997;278(5337):425-31.
1997: C L Fisher; Diane E Cabelli; RA Hallewell; P Beroza; Terence P Lo; Elizabeth D Getzoff; John A Tainer
Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase.
Proteins 1997;29(1):103-12.
1997: Katrina T Forest; John A Tainer
Type-4 pilus-structure: outside to inside and top to bottom--a minireview.
Gene 1997;192(1):165-9.
1997: Maurice Boissinot; S Karnas; James R Lepock; Diane E Cabelli; John A Tainer; Elizabeth D Getzoff; RA Hallewell
Function of the Greek key connection analysed using circular permutants of superoxide dismutase.
The EMBO journal 1997;16(9):2171-8.
1996: Y Bourne; S M Redford; Howard M Steinman; James R Lepock; John A Tainer; Elizabeth D Getzoff
Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):12774-9.
1996: Geir Slupphaug; Clifford D Mol; B Kavli; Andrew S Arvai; Hans E Krokan; John A Tainer
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature 1996;384(6604):87-92.
1996: Clifford D Mol; J M Harris; E M McIntosh; John A Tainer
Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits.
Structure (London, England : 1993) 1996;4(9):1077-92.
1996: Mark H Watson; Y Bourne; Andrew S Arvai; M J Hickey; A Santiago; S L Bernstein; John A Tainer; Steven I Reed
A mutation in the human cyclin-dependent kinase interacting protein, CksHs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly.
Journal of molecular biology 1996;261(5):646-57.
1996: B Kavli; Geir Slupphaug; Clifford D Mol; Andrew S Arvai; S B Peterson; John A Tainer; Hans E Krokan
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
The EMBO journal 1996;15(13):3442-7.
1996: Gloria E. Borgstahl; H E Parge; M J Hickey; M J Johnson; Maurice Boissinot; RA Hallewell; James R Lepock; Diane E Cabelli; John A Tainer
Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface.
Biochemistry 1996;35(14):4287-97.
1996: Y Bourne; Mark H Watson; M J Hickey; W Holmes; W Rocque; Steven I Reed; John A Tainer
Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.
Cell 1996;84(6):863-74.
1996: Katrina T Forest; S L Bernstein; Elizabeth D Getzoff; Magdalene So; G Tribbick; H M Geysen; C D Deal; John A Tainer
Assembly and antigenicity of the Neisseria gonorrhoeae pilus mapped with antibodies.
Infection and immunity 1996;64(2):644-52.
1995: Leslie A Kuhn; C A Swanson; Michael E Pique; John A Tainer; Elizabeth D Getzoff
Atomic and residue hydrophilicity in the context of folded protein structures.
Proteins 1995;23(4):536-47.
1995: H E Parge; Katrina T Forest; M J Hickey; D A Christensen; Elizabeth D Getzoff; John A Tainer
Structure of the fibre-forming protein pilin at 2.6 A resolution.
Nature 1995;378(6552):32-8.
1995: Y Bourne; Andrew S Arvai; S L Bernstein; Mark H Watson; Steven I Reed; J E Endicott; M E Noble; L N Johnson; John A Tainer
Crystal structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10232-6.
1995: Clifford D Mol; Andrew S Arvai; R J Sanderson; Geir Slupphaug; B Kavli; Hans E Krokan; Dale W Mosbaugh; John A Tainer
Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA.
Cell 1995;82(5):701-8.
1995: M M Thayer; H Ahern; D Xing; Richard P Cunningham; John A Tainer
Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.
The EMBO journal 1995;14(16):4108-20.
1995: G Barzilay; Clifford D Mol; C N Robson; L J Walker; Richard P Cunningham; John A Tainer; Ian D Hickson
Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1.
Nature structural biology 1995;2(7):561-8.
1995: Andrew S Arvai; Y Bourne; M J Hickey; John A Tainer
Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain.
Journal of molecular biology 1995;249(5):835-42.
1995: M A McTigue; S L Bernstein; D R Williams; John A Tainer
Purification and crystallization of a schistosomal glutathione S-transferase.
Proteins 1995;22(1):55-7.
1995: Clifford D Mol; Andrew S Arvai; Geir Slupphaug; B Kavli; I Alseth; Hans E Krokan; John A Tainer
Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis.
Cell 1995;80(6):869-78.
1995: Clifford D Mol; C F Kuo; M M Thayer; Richard P Cunningham; John A Tainer
Structure and function of the multifunctional DNA-repair enzyme exonuclease III.
Nature 1995;374(6520):381-6.
1995: M A McTigue; D R Williams; John A Tainer
Crystal structures of a schistosomal drug and vaccine target: glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel.
Journal of molecular biology 1995;246(1):21-7.
1995: John A Tainer; M M Thayer; Richard P Cunningham
DNA repair proteins.
Current opinion in structural biology 1995;5(1):20-6.
1995: Andrew S Arvai; Y Bourne; D Williams; Steven I Reed; John A Tainer
Crystallization and preliminary crystallographic study of human CksHs1: a cell cycle regulatory protein.
Proteins 1995;21(1):70-3.
1994: C F Kuo; Clifford D Mol; M M Thayer; Richard P Cunningham; John A Tainer
Structure and function of the DNA repair enzyme exonuclease III from E. coli.
Annals of the New York Academy of Sciences 1994;726():223-34; discussion 234-5.
1994: Richard P Cunningham; H Ahern; D Xing; M M Thayer; John A Tainer
Structure and function of Escherichia coli endonuclease III.
Annals of the New York Academy of Sciences 1994;726():215-22.
1994: C L Fisher; Diane E Cabelli; John A Tainer; RA Hallewell; Elizabeth D Getzoff
The role of arginine 143 in the electrostatics and mechanism of Cu,Zn superoxide dismutase: computational and experimental evaluation by mutational analysis.
Proteins 1994;19(1):24-34.
1993: H E Parge; Andrew S Arvai; D J Murtari; Steven I Reed; John A Tainer
Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control.
Science (New York, N.Y.) 1993;262(5132):387-95.
1993: John A Tainer; R P Cunningham
Molecular recognition in DNA-binding proteins and enzymes.
Current opinion in biotechnology 1993;4(4):474-83.
1993: Maurice Boissinot; Leslie A Kuhn; P Lee; C L Fisher; Y Wang; RA Hallewell; John A Tainer
Rational design and expression of a heparin-targeted human superoxide dismutase.
Biochemical and biophysical research communications 1993;190(1):250-6.
1993: C F Kuo; Duncan E McRee; Richard P Cunningham; John A Tainer
Purification, crystallization and space group determination of DNA repair enzyme exonuclease III from E. coli.
Journal of molecular biology 1993;229(1):239-42.
1992: Leslie A Kuhn; M A Siani; Michael E Pique; C L Fisher; Elizabeth D Getzoff; John A Tainer
The interdependence of protein surface topography and bound water molecules revealed by surface accessibility and fractal density measures.
Journal of molecular biology 1992;228(1):13-22.
1992: C F Kuo; Duncan E McRee; C L Fisher; S F O'Handley; Richard P Cunningham; John A Tainer
Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III.
Science (New York, N.Y.) 1992;258(5081):434-40.
1992: Gloria E. Borgstahl; H E Parge; M J Hickey; W F Beyer; RA Hallewell; John A Tainer
The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles.
Cell 1992;71(1):107-18.
1992: C F Kuo; Duncan E McRee; Richard P Cunningham; John A Tainer
Crystallization and crystallographic characterization of the iron-sulfur-containing DNA-repair enzyme endonuclease III from Escherichia coli.
Journal of molecular biology 1992;227(1):347-51.
1992: John A Tainer; Victoria A Roberts; Elizabeth D Getzoff
Protein metal-binding sites.
Current opinion in biotechnology 1992;3(4):378-87.
1992: H E Parge; RA Hallewell; John A Tainer
Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6109-13.
1991: RA Hallewell; K C Imlay; P Lee; N M Fong; C Gallegos; Elizabeth D Getzoff; John A Tainer; Diane E Cabelli; P Tekamp-Olson; G T Mullenbach
Thermostabilization of recombinant human and bovine CuZn superoxide dismutases by replacement of free cysteines.
Biochemical and biophysical research communications 1991;181(1):474-80.
1991: John A Tainer; Victoria A Roberts; Elizabeth D Getzoff
Metal-binding sites in proteins.
Current opinion in biotechnology 1991;2(4):582-91.
1991: Victoria A Roberts; H C Freeman; Arthur J Olson; John A Tainer; Elizabeth D Getzoff
Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c.
The Journal of biological chemistry 1991;266(20):13431-41.
1991: Ronald J Nachman; Victoria A Roberts; H J Dyson; G M Holman; John A Tainer
Active conformation of an insect neuropeptide family.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(10):4518-22.
1991: John A Tainer; C D Deal; H M Geysen; Victoria A Roberts; Elizabeth D Getzoff
Defining antibody-antigen recognition: towards engineered antibodies and epitopes.
International reviews of immunology 1991;7(2):165-88.
1991: C L Fisher; RA Hallewell; Victoria A Roberts; John A Tainer; Elizabeth D Getzoff
Probing the structural basis for enzyme-substrate recognition in Cu,Zn superoxide dismutase.
Free radical research communications 1991;12-13 Pt 1():287-96.
1991: Victoria A Roberts; C L Fisher; S M Redford; Duncan E McRee; H E Parge; Elizabeth D Getzoff; John A Tainer
Mechanism and atomic structure of superoxide dismutase.
Free radical research communications 1991;12-13 Pt 1():269-78.
1990: Leslie A Kuhn; John H Griffin; C L Fisher; J S Greengard; B N Bouma; F España; John A Tainer
Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8506-10.
1990: Victoria A Roberts; B L Iverson; S A Iverson; Stephen J Benkovic; Richard A Lerner; Elizabeth D Getzoff; John A Tainer
Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6654-8.
1990: C L Fisher; John A Tainer; Michael E Pique; Elizabeth D Getzoff
Visualization of molecular flexibility and its effects on electrostatic recognition.
Journal of molecular graphics 1990;8(3):125-32, 145.
1990: Duncan E McRee; S M Redford; Elizabeth D Getzoff; James R Lepock; RA Hallewell; John A Tainer
Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine.
The Journal of biological chemistry 1990;265(24):14234-41.
1990: B L Iverson; S A Iverson; Victoria A Roberts; Elizabeth D Getzoff; John A Tainer; Stephen J Benkovic; Richard A Lerner
Metalloantibodies.
Science (New York, N.Y.) 1990;249(4969):659-62.
1990: S M Redford; Duncan E McRee; Elizabeth D Getzoff; Howard M Steinman; John A Tainer
Crystallographic characterization of a Cu,Zn superoxide dismutase from Photobacterium leiognathi.
Journal of molecular biology 1990;212(3):449-51.
1989: Duncan E McRee; John A Tainer; T E Meyer; J Van Beeumen; M A Cusanovich; Elizabeth D Getzoff
Crystallographic structure of a photoreceptor protein at 2.4 A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6533-7.
1989: RA Hallewell; I Laria; A Tabrizi; G Carlin; Elizabeth D Getzoff; John A Tainer; L S Cousens; G T Mullenbach
Genetically engineered polymers of human CuZn superoxide dismutase. Biochemistry and serum half-lives.
The Journal of biological chemistry 1989;264(9):5260-8.
1988: G T Mullenbach; A Tabrizi; B D Irvine; G I Bell; John A Tainer; RA Hallewell
Selenocysteine's mechanism of incorporation and evolution revealed in cDNAs of three glutathione peroxidases.
Protein engineering 1988;2(3):239-46.
1988: Elizabeth D Getzoff; H E Parge; Duncan E McRee; John A Tainer
Understanding the structure and antigenicity of gonococcal pili.
Reviews of infectious diseases 1988;10 Suppl 2():S296-9.
1988: John A Tainer; RA Hallewell; Victoria A Roberts; H E Parge; Elizabeth D Getzoff
Probing enzyme-substrate recognition and catalytic mechanism in Cu,Zn superoxide dismutase.
Basic life sciences 1988;49():635-40.
1988: Elizabeth D Getzoff; John A Tainer; Richard A Lerner; H M Geysen
The chemistry and mechanism of antibody binding to protein antigens.
Advances in immunology 1988;43():1-98.
1987: T M Fieser; John A Tainer; H M Geysen; R A Houghten; Richard A Lerner
Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein alpha-helix.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8568-72.
1987: H E Parge; Duncan E McRee; M A Capozza; S L Bernstein; Elizabeth D Getzoff; John A Tainer
Three dimensional structure of bacterial pili.
Antonie van Leeuwenhoek 1987;53(6):447-53.
1986: H E Parge; Elizabeth D Getzoff; C S Scandella; RA Hallewell; John A Tainer
Crystallographic characterization of recombinant human CuZn superoxide dismutase.
The Journal of biological chemistry 1986;261(34):16215-8.