Username

Password

Forgot Password?

Preview

Sign-in free and Explore the Exciting World of BiomedExperts:

Over 1.500.000 Profiles
More than 1.800 Organizations worldwide
State of the Art Network Visualizations

Manage your own Profile
Locate Experts in your Country/Region
Locate Experts in your 1. and 2. Level Network
Connect to Experts Worldwide

NetworkView

John Tainer

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

Research Profile (preview)

Concepts & Ideas

Procedures

X-Ray Crystallography

Chemicals & Drugs

Genes & Molecular Sequences

Amino Acid Sequence

Physiology

Phenomena

Living Beings

Escherichia coli

Sign-in to see full Profile

Network (preview)

Co-Publications
Name
58
Getzoff, Elizabeth
34
Arvai, Andrew
19
Mol, Clifford
15
Hallewell, RA
14
Roberts, Victoria
13
Cunningham, Richard
12
Cabelli, Diane
12
Hopfner, Karl-Peter
12
Stuehr, Dennis
11
Silverman, David
11
Perry, Jefferson
11
Hosfield, David
11
Nick, Harry
11
Lepock, James
9
McRee, Duncan

Sign-in to see all Coauthors

Publications

TOP 3
Aleshin Alexander E; Gramatikova Svetlana; Hura Gregory L; Bobkov Andrey; Strongin Alex Y; Stec Boguslaw; Tainer John A; Liddington Robert C; Smith Jeffrey W
Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case.
Williams R Scott; Dodson Gerald E; Limbo Oliver; Yamada Yoshiki; Williams Jessica S; Guenther Grant; Classen Scott; Glover J N Mark; Iwasaki Hiroshi; Russell Paul; Tainer John A
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.
Bernstein N K; Hammel M; Mani R S; Weinfeld M; Pelikan M; Tainer J A; Glover J N M
Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase.

Sign-in to see all Publications

Sign in free and see...

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the visualized research activity
of experts around the globe

Sign-in to see more

Geonetwork of John Tainer (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

Sign-in to see more

All Publications

2009: Aleshin Alexander E; Gramatikova Svetlana; Hura Gregory L; Bobkov Andrey; Strongin Alex Y; Stec Boguslaw; Tainer John A; Liddington Robert C; Smith Jeffrey W
Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case.
Structure (London, England : 1993) 2009;17(11):1465-75.
2009: Williams R Scott; Dodson Gerald E; Limbo Oliver; Yamada Yoshiki; Williams Jessica S; Guenther Grant; Classen Scott; Glover J N Mark; Iwasaki Hiroshi; Russell Paul; Tainer John A
Nbs1 flexibly tethers Ctp1 and Mre11-Rad50 to coordinate DNA double-strand break processing and repair.
Cell 2009;139(1):87-99.
2009: Bernstein N K; Hammel M; Mani R S; Weinfeld M; Pelikan M; Tainer J A; Glover J N M
Mechanism of DNA substrate recognition by the mammalian DNA repair enzyme, Polynucleotide Kinase.
Nucleic acids research 2009;37(18):6161-73.
2009: Hura Greg L; Menon Angeli L; Hammel Michal; Rambo Robert P; Poole Farris L; Tsutakawa Susan E; Jenney Francis E; Classen Scott; Frankel Kenneth A; Hopkins Robert C; Yang Sung-Jae; Scott Joseph W; Dillard Bret D; Adams Michael W W; Tainer John A
Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS).
Nature methods 2009;6(8):606-12.
2009: Perry J Jefferson P; Harris Rodney M; Moiani Davide; Olson Arthur J; Tainer John A
p38alpha MAP kinase C-terminal domain binding pocket characterized by crystallographic and computational analyses.
Journal of molecular biology 2009;391(1):1-11.
2009: Tubbs Julie L; Latypov Vitaly; Kanugula Sreenivas; Butt Amna; Melikishvili Manana; Kraehenbuehl Rolf; Fleck Oliver; Marriott Andrew; Watson Amanda J; Verbeek Barbara; McGown Gail; Thorncroft Mary; Santibanez-Koref Mauro F; Millington Christopher; Arvai Andrew S; Kroeger Matthew D; Peterson Lisa A; Williams David M; Fried Michael G; Margison Geoffrey P; Pegg Anthony E; Tainer John A
Flipping of alkylated DNA damage bridges base and nucleotide excision repair.
Nature 2009;459(7248):808-13.
2009: Perry J Jefferson P; Hitomi Kenichi; Tainer John A
Flexibility promotes fidelity.
Structure (London, England : 1993) 2009;17(5):633-4.
2009: Prudden John; Perry J Jefferson P; Arvai Andrew S; Tainer John A; Boddy Michael N
Molecular mimicry of SUMO promotes DNA repair.
Nature structural & molecular biology 2009;16(5):509-16.
2009: Hitomi Kenichi; DiTacchio Luciano; Arvai Andrew S; Yamamoto Junpei; Kim Sang-Tae; Todo Takeshi; Tainer John A; Iwai Shigenori; Panda Satchidananda; Getzoff Elizabeth D
Functional motifs in the (6-4) photolyase crystal structure make a comparative framework for DNA repair photolyases and clock cryptochromes.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(17):6962-7.
2009: Perry J Jefferson P; Hearn Amy S; Cabelli Diane E; Nick Harry S; Tainer John A; Silverman David N
Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis.
Biochemistry 2009;48(15):3417-24.
2009: Dalhus Bjørn; Arvai Andrew S; Rosnes Ida; Olsen Øyvind E; Backe Paul H; Alseth Ingrun; Gao Honghai; Cao Weiguo; Tainer John A; Bjørås Magnar
Structures of endonuclease V with DNA reveal initiation of deaminated adenine repair.
Nature structural & molecular biology 2009;16(2):138-43.
2009: Shin David S; Didonato Michael; Barondeau David P; Hura Greg L; Hitomi Chiharu; Berglund J Andrew; Getzoff Elizabeth D; Cary S Craig; Tainer John A
Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis.
Journal of molecular biology 2009;385(5):1534-55.
2009: Min Xiaoshan; Akella Radha; He Haixia; Humphreys John M; Tsutakawa Susan E; Lee Seung-Jae; Tainer John A; Cobb Melanie H; Goldsmith Elizabeth J
The structure of the MAP2K MEK6 reveals an autoinhibitory dimer.
Structure (London, England : 1993) 2009;17(1):96-104.
2008: Williams R Scott; Williams Gareth J; Tainer John A
A charged performance by gp17 in viral packaging.
Cell 2008;135(7):1169-71.
2008: Garcin Elsa D; Arvai Andrew S; Rosenfeld Robin J; Kroeger Matt D; Crane Brian R; Andersson Gunilla; Andrews Glen; Hamley Peter J; Mallinder Philip R; Nicholls David J; St-Gallay Stephen A; Tinker Alan C; Gensmantel Nigel P; Mete Antonio; Cheshire David R; Connolly Stephen; Stuehr Dennis J; Aberg Anders; Wallace Alan V; Tainer John A; Getzoff Elizabeth D
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nature chemical biology 2008;4(11):700-7.
2008: Edwards Ross A; Lee Megan S; Tsutakawa Susan E; Williams R Scott; Nazeer I; Kleiman F E; Tainer John A; Glover J N Mark
The BARD1 C-terminal domain structure and interactions with polyadenylation factor CstF-50.
Biochemistry 2008;47(44):11446-56.
2008: Williams R Scott; Moncalian Gabriel; Williams Jessica S; Yamada Yoshiki; Limbo Oliver; Shin David S; Groocock Lynda M; Cahill Dana; Hitomi Chiharu; Guenther Grant; Moiani Davide; Carney James P; Russell Paul; Tainer John A
Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Cell 2008;135(1):97-109.
2008: Fang Qingming; Noronha Anne M; Murphy Sebastian P; Wilds Christopher J; Tubbs Julie L; Tainer John A; Chowdhury Goutam; Guengerich F Peter; Pegg Anthony E
Repair of O6-G-alkyl-O6-G interstrand cross-links by human O6-alkylguanine-DNA alkyltransferase.
Biochemistry 2008;47(41):10892-903.
2008: Syson Karl; Tomlinson Christopher; Chapados Brian R; Sayers Jon R; Tainer John A; Williams Nicholas H; Grasby Jane A
Three metal ions participate in the reaction catalyzed by T5 flap endonuclease.
The Journal of biological chemistry 2008;283(42):28741-6.
2008: Pebernard Stephanie; Perry J Jefferson P; Tainer John A; Boddy Michael N
Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability.
Molecular biology of the cell 2008;19(10):4099-109.
2008: Chrencik Jill E; Brooun Alexei; Zhang Hui; Mathews Irimpan I; Hura Greg L; Foster Scott A; Perry J Jefferson P; Streiff Markus; Ramage Paul; Widmer Hans; Bokoch Gary M; Tainer John A; Weckbecker Gisbert; Kuhn Peter
Structural basis of guanine nucleotide exchange mediated by the T-cell essential Vav1.
Journal of molecular biology 2008;380(5):828-43.
2008: Fan Li; Fuss Jill O; Cheng Quen J; Arvai Andrew S; Hammel Michal; Roberts Victoria A; Cooper Priscilla K; Tainer John A
XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutations.
Cell 2008;133(5):789-800.
2008: Garcin Elsa D; Hosfield David J; Desai Sunil A; Haas Brian J; Björas Magnar; Cunningham Richard P; Tainer John A
DNA apurinic-apyrimidinic site binding and excision by endonuclease IV.
Nature structural & molecular biology 2008;15(5):515-22.
2008: Perry J Jefferson P; Tainer John A; Boddy Michael N
A SIM-ultaneous role for SUMO and ubiquitin.
Trends in biochemical sciences 2008;33(5):201-8.
2007: Roberts Blaine R; Tainer John A; Getzoff Elizabeth D; Malencik Dean A; Anderson Sonia R; Bomben Valerie C; Meyers Kathrin R; Karplus P Andrew; Beckman Joseph S
Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS.
Journal of molecular biology 2007;373(4):877-90.
2007: Prudden John; Pebernard Stephanie; Raffa Grazia; Slavin Daniela A; Perry J Jefferson P; Tainer John A; McGowan Clare H; Boddy Michael N
SUMO-targeted ubiquitin ligases in genome stability.
The EMBO journal 2007;26(18):4089-101.
2007: Putnam Christopher D; Hammel Michal; Hura Greg L; Tainer John A
X-ray solution scattering (SAXS) combined with crystallography and computation: defining accurate macromolecular structures, conformations and assemblies in solution.
Quarterly reviews of biophysics 2007;40(3):191-285.
2007: Williams R Scott; Williams Jessica S; Tainer John A
Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template.
Biochemistry and cell biology = Biochimie et biologie cellulaire 2007;85(4):509-20.
2007: Williams Ryan; Sengerová Blanka; Osborne Sadie; Syson Karl; Ault Sophie; Kilgour Anna; Chapados Brian R; Tainer John A; Sayers Jon R; Grasby Jane A
Comparison of the catalytic parameters and reaction specificities of a phage and an archaeal flap endonuclease.
Journal of molecular biology 2007;371(1):34-48.
2007: Tubbs Julie L; Pegg Anthony E; Tainer John A
DNA binding, nucleotide flipping, and the helix-turn-helix motif in base repair by O6-alkylguanine-DNA alkyltransferase and its implications for cancer chemotherapy.
DNA repair 2007;6(8):1100-15.
2007: Tsutakawa Susan E; Hura Greg L; Frankel Ken A; Cooper Priscilla K; Tainer John A
Structural analysis of flexible proteins in solution by small angle X-ray scattering combined with crystallography.
Journal of structural biology 2007;158(2):214-23.
2007: Hitomi Kenichi; Iwai Shigenori; Tainer John A
The intricate structural chemistry of base excision repair machinery: implications for DNA damage recognition, removal, and repair.
DNA repair 2007;6(4):410-28.
2007: Williams R Scott; Tainer John A
Learning our ABCs: Rad50 directs MRN repair functions via adenylate kinase activity from the conserved ATP binding cassette.
Molecular cell 2007;25(6):789-91.
2007: Barondeau David P; Kassmann Carey J; Tainer John A; Getzoff Elizabeth D
The case of the missing ring: radical cleavage of a carbon-carbon bond and implications for GFP chromophore biosynthesis.
Journal of the American Chemical Society 2007;129(11):3118-26.
2007: Yamagata Atsushi; Tainer John A
Hexameric structures of the archaeal secretion ATPase GspE and implications for a universal secretion mechanism.
The EMBO journal 2007;26(3):878-90.
2007: Ivanov Ivaylo; Tainer John A; McCammon J Andrew
Unraveling the three-metal-ion catalytic mechanism of the DNA repair enzyme endonuclease IV.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1465-70.
2007: Vijayakumar Sangeetha; Chapados Brian R; Schmidt Kristina H; Kolodner Richard D; Tainer John A; Tomkinson Alan E
The C-terminal domain of yeast PCNA is required for physical and functional interactions with Cdc9 DNA ligase.
Nucleic acids research 2007;35(5):1624-37.
2006: Pascal John M; Tsodikov Oleg V; Hura Greg L; Song Wei; Cotner Elizabeth A; Classen Scott; Tomkinson Alan E; Tainer John A; Ellenberger Tom
A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA.
Molecular cell 2006;24(2):279-91.
2006: Craig Lisa; Volkmann Niels; Arvai Andrew S; Pique Michael E; Yeager Mark; Egelman Edward H; Tainer John A
Type IV pilus structure by cryo-electron microscopy and crystallography: implications for pilus assembly and functions.
Molecular cell 2006;23(5):651-62.
2006: Sundheim Ottar; Vågbø Cathrine B; Bjørås Magnar; Sousa Mirta M L; Talstad Vivi; Aas Per A; Drabløs Finn; Krokan Hans E; Tainer John A; Slupphaug Geir
Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage.
The EMBO journal 2006;25(14):3389-97.
2006: Perry J Jefferson P; Yannone Steven M; Holden Lauren G; Hitomi Chiharu; Asaithamby Aroumougame; Han Seungil; Cooper Priscilla K; Chen David J; Tainer John A
WRN exonuclease structure and molecular mechanism imply an editing role in DNA end processing.
Nature structural & molecular biology 2006;13(5):414-22.
2006: Fan Li; Kim Sangbumn; Farr Carol L; Schaefer Kevin T; Randolph Kathleen M; Tainer John A; Kaguni Laurie S
A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase.
Journal of molecular biology 2006;358(5):1229-43.
2006: Fan Li; Arvai Andrew S; Cooper Priscilla K; Iwai Shigenori; Hanaoka Fumio; Tainer John A
Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repair.
Molecular cell 2006;22(1):27-37.
2006: Barondeau David P; Kassmann Carey J; Tainer John A; Getzoff Elizabeth D
Understanding GFP posttranslational chemistry: structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation.
Journal of the American Chemical Society 2006;128(14):4685-93.
2006: Barondeau David P; Tainer John A; Getzoff Elizabeth D
Structural evidence for an enolate intermediate in GFP fluorophore biosynthesis.
Journal of the American Chemical Society 2006;128(10):3166-8.
2006: Ivanov Ivaylo; Chapados Brian R; McCammon J Andrew; Tainer John A
Proliferating cell nuclear antigen loaded onto double-stranded DNA: dynamics, minor groove interactions and functional implications.
Nucleic acids research 2006;34(20):6023-33.
2006: Doi Yusuke; Katafuchi Atsushi; Fujiwara Yoshie; Hitomi Kenichi; Tainer John A; Ide Hiroshi; Iwai Shigenori
Synthesis and characterization of oligonucleotides containing 2'-fluorinated thymidine glycol as inhibitors of the endonuclease III reaction.
Nucleic acids research 2006;34(5):1540-51.
2005: Wood Timothy I; Barondeau David P; Hitomi Chiharu; Kassmann Carey J; Tainer John A; Getzoff Elizabeth D
Defining the role of arginine 96 in green fluorescent protein fluorophore biosynthesis.
Biochemistry 2005;44(49):16211-20.
2005: Ayala Patricia; Wilbur J Scott; Wetzler Lee M; Tainer John A; Snyder Aurelie; So Magdalene
The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca(2+) transients in infected epithelial cells.
Cellular microbiology 2005;7(12):1736-48.
2005: Putnam Christopher D; Tainer John A
Protein mimicry of DNA and pathway regulation.
DNA repair 2005;4(12):1410-20.
2005: Ayala Idelisa; Perry J Jefferson P; Szczepanski Jan; Tainer John A; Vala Martin T; Nick Harry S; Silverman David N
Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine.
Biophysical journal 2005;89(6):4171-9.
2005: Sarker Altaf H; Tsutakawa Susan E; Kostek Seth; Ng Cliff; Shin David S; Peris Marian; Campeau Eric; Tainer John A; Nogales Eva; Cooper Priscilla K
Recognition of RNA polymerase II and transcription bubbles by XPG, CSB, and TFIIH: insights for transcription-coupled repair and Cockayne Syndrome.
Molecular cell 2005;20(2):187-98.
2005: Williams R Scott; Tainer John A
A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks.
Molecular cell 2005;19(6):724-6.
2005: Simeoni Federica; Arvai Andy; Bello Paul; Gondeau Claire; Hopfner Karl-Peter; Neyroz Paolo; Heitz Frederic; Tainer John; Divita Gilles
Biochemical characterization and crystal structure of a Dim1 family associated protein: Dim2.
Biochemistry 2005;44(36):11997-2008.
2005: Huffman Joy L; Sundheim Ottar; Tainer John A
DNA base damage recognition and removal: new twists and grooves.
Mutation research 2005;577(1-2):55-76.
2005: Tubbs Julie L; Tainer John A; Getzoff Elizabeth D
Crystallographic structures of Discosoma red fluorescent protein with immature and mature chromophores: linking peptide bond trans-cis isomerization and acylimine formation in chromophore maturation.
Biochemistry 2005;44(29):9833-40.
2005: Crowther Lynette J; Yamagata Atsushi; Craig Lisa; Tainer John A; Donnenberg Michael S
The ATPase activity of BfpD is greatly enhanced by zinc and allosteric interactions with other Bfp proteins.
The Journal of biological chemistry 2005;280(26):24839-48.
2005: Barondeau David P; Kassmann Carey J; Tainer John A; Getzoff Elizabeth D
Understanding GFP chromophore biosynthesis: controlling backbone cyclization and modifying post-translational chemistry.
Biochemistry 2005;44(6):1960-70.
2005: Doi Yusuke; Hitomi Kenichi; Tainer John A; Iwai Shigenori
Synthesis of oligonucleotides containing 2'-fluorinated thymidine glycol as mechanism-based inhibitors of endonuclease III.
Nucleic acids symposium series (2004) 2005;(49):195-6.
2004: Manuel Raymond C; Hitomi Kenichi; Arvai Andrew S; House Paul G; Kurtz Andrew J; Dodson M L; McCullough Amanda K; Tainer John A; Lloyd R Stephen
Reaction intermediates in the catalytic mechanism of Escherichia coli MutY DNA glycosylase.
The Journal of biological chemistry 2004;279(45):46930-9.
2004: Garcin Elsa D; Bruns Christopher M; Lloyd Sarah J; Hosfield David J; Tiso Mauro; Gachhui Ratan; Stuehr Dennis J; Tainer John A; Getzoff Elizabeth D
Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase.
The Journal of biological chemistry 2004;279(36):37918-27.
2004: Shin David S; Chahwan Charly; Huffman Joy L; Tainer John A
Structure and function of the double-strand break repair machinery.
DNA repair 2004;3(8-9):863-73.
2004: Daniels Douglas S; Woo Tammy T; Luu Kieu X; Noll David M; Clarke Neil D; Pegg Anthony E; Tainer John A
DNA binding and nucleotide flipping by the human DNA repair protein AGT.
Nature structural & molecular biology 2004;11(8):714-20.
2004: Barondeau David P; Kassmann Carey J; Bruns Cami K; Tainer John A; Getzoff Elizabeth D
Nickel superoxide dismutase structure and mechanism.
Biochemistry 2004;43(25):8038-47.
2004: Greenleaf William B; Perry J Jefferson P; Hearn Amy S; Cabelli Diane E; Lepock James R; Stroupe M Elizabeth; Tainer John A; Nick Harry S; Silverman David N
Role of hydrogen bonding in the active site of human manganese superoxide dismutase.
Biochemistry 2004;43(22):7038-45.
2004: de Jager Martijn; Trujillo Kelly M; Sung Patrick; Hopfner Karl-Peter; Carney James P; Tainer John A; Connelly John C; Leach David R F; Kanaar Roland; Wyman Claire
Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex.
Journal of molecular biology 2004;339(4):937-49.
2004: Connolly Stephen; Aberg Anders; Arvai Andrew; Beaton Haydn G; Cheshire David R; Cook Anthony R; Cooper Sally; Cox David; Hamley Peter; Mallinder Phil; Millichip Ian; Nicholls David J; Rosenfeld Robin J; St-Gallay Stephen A; Tainer John; Tinker Alan C; Wallace Alan V
2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.
Journal of medicinal chemistry 2004;47(12):3320-3.
2004: Qiu Junzhuan; Liu Ren; Chapados Brian R; Sherman Mark; Tainer John A; Shen Binghui
Interaction interface of human flap endonuclease-1 with its DNA substrates.
The Journal of biological chemistry 2004;279(23):24394-402.
2004: Craig Lisa; Pique Michael E; Tainer John A
Type IV pilus structure and bacterial pathogenicity.
Nature reviews. Microbiology 2004;2(5):363-78.
2004: Hearn Amy S; Fan Li; Lepock James R; Luba James P; Greenleaf William B; Cabelli Diane E; Tainer John A; Nick Harry S; Silverman David N
Amino acid substitution at the dimeric interface of human manganese superoxide dismutase.
The Journal of biological chemistry 2004;279(7):5861-6.
2004: Chapados Brian R; Hosfield David J; Han Seungil; Qiu Junzhuan; Yelent Biana; Shen Binghui; Tainer John A
Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair.
Cell 2004;116(1):39-50.
2004: Moncalian Gabriel; Lengsfeld Bettina; Bhaskara Venugopal; Hopfner Karl-Peter; Karcher Annette; Alden Erinn; Tainer John A; Paull Tanya T
The rad50 signature motif: essential to ATP binding and biological function.
Journal of molecular biology 2004;335(4):937-51.
2004: Arthur L Matthew; Gustausson Karin; Hopfner Karl-Peter; Carson Christian T; Stracker Travis H; Karcher Annette; Felton Diana; Weitzman Matthew D; Tainer John; Carney James P
Structural and functional analysis of Mre11-3.
Nucleic acids research 2004;32(6):1886-93.
2003: Barondeau David P; Putnam Christopher D; Kassmann Carey J; Tainer John A; Getzoff Elizabeth D
Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(21):12111-6.
2003: DiDonato Michael; Craig Lisa; Huff Mary E; Thayer Maria M; Cardoso Rosa M F; Kassmann Carey J; Lo Terence P; Bruns Cami K; Powers Evan T; Kelly Jeffery W; Getzoff Elizabeth D; Tainer John A
ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization.
Journal of molecular biology 2003;332(3):601-15.
2003: Shin David S; Pellegrini Luca; Daniels Douglas S; Yelent Biana; Craig Lisa; Bates Debbie; Yu David S; Shivji Mahmud K; Hitomi Chiharu; Arvai Andrew S; Volkmann Niels; Tsuruta Hiro; Blundell Tom L; Venkitaraman Ashok R; Tainer John A
Full-length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2.
The EMBO journal 2003;22(17):4566-76.
2003: Huffman Joy L; Li Hong; White Robert H; Tainer John A
Structural basis for recognition and catalysis by the bifunctional dCTP deaminase and dUTPase from Methanococcus jannaschii.
Journal of molecular biology 2003;331(4):885-96.
2003: McMurray Cynthia T; Tainer John A
Cancer, cadmium and genome integrity.
Nature genetics 2003;34(3):239-41.
2003: Wang Michael; Howell Joseph M; Libbey Jane E; Tainer John A; Fujinami Robert S
Manganese superoxide dismutase induction during measles virus infection.
Journal of medical virology 2003;70(3):470-4.
2003: Craig Lisa; Taylor Ronald K; Pique Michael E; Adair Brian D; Arvai Andrew S; Singh Mona; Lloyd Sarah J; Shin David S; Getzoff Elizabeth D; Yeager Mark; Forest Katrina T; Tainer John A
Type IV pilin structure and assembly: X-ray and EM analyses of Vibrio cholerae toxin-coregulated pilus and Pseudomonas aeruginosa PAK pilin.
Molecular cell 2003;11(5):1139-50.
2003: Hopfner Karl-Peter; Tainer John A
Rad50/SMC proteins and ABC transporters: unifying concepts from high-resolution structures.
Current opinion in structural biology 2003;13(2):249-55.
2003: Cardoso Rosa M F; Daniels Douglas S; Bruns Christopher M; Tainer John A
Characterization of the electrophile binding site and substrate binding mode of the 26-kDa glutathione S-transferase from Schistosoma japonicum.
Proteins 2003;51(1):137-46.
2003: Hearn Amy S; Stroupe M Elizabeth; Cabelli Diane E; Ramilo Cecilia A; Luba James P; Tainer John A; Nick Harry S; Silverman David N
Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: insertion of valine C gamma into the substrate access channel.
Biochemistry 2003;42(10):2781-9.
2003: Aoyagi Mika; Arvai Andrew S; Tainer John A; Getzoff Elizabeth D
Structural basis for endothelial nitric oxide synthase binding to calmodulin.
The EMBO journal 2003;22(4):766-75.
2003: Brudler Ronald; Hitomi Kenichi; Daiyasu Hiromi; Toh Hiroyuki; Kucho Ken-ichi; Ishiura Masahiro; Kanehisa Minoru; Roberts Victoria A; Todo Takeshi; Tainer John A; Getzoff Elizabeth D
Identification of a new cryptochrome class. Structure, function, and evolution.
Molecular cell 2003;11(1):59-67.
2002: Cardoso Rosa M F; Thayer Maria M; DiDonato Michael; Lo Terence P; Bruns Cami K; Getzoff Elizabeth D; Tainer John A
Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase.
Journal of molecular biology 2002;324(2):247-56.
2002: Rosenfeld Robin J; Garcin Elsa D; Panda Koustubh; Andersson Gunilla; Aberg Anders; Wallace Alan V; Morris Garrett M; Olson Arthur J; Stuehr Dennis J; Tainer John A; Getzoff Elizabeth D
Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.
Biochemistry 2002;41(47):13915-25.
2002: Abdalla Abdel-Monem; Bruns Christopher M; Tainer John A; Mannervik Bengt; Stenberg Gun
Design of a monomeric human glutathione transferase GSTP1, a structurally stable but catalytically inactive protein.
Protein engineering 2002;15(10):827-34.
2002: Hopfner Karl-Peter; Craig Lisa; Moncalian Gabriel; Zinkel Robert A; Usui Takehiko; Owen Barbara A L; Karcher Annette; Henderson Brendan; Bodmer Jean-Luc; McMurray Cynthia T; Carney James P; Petrini John H J; Tainer John A
The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair.
Nature 2002;418(6897):562-6.
2002: Morris May C; Gondeau Claire; Tainer John A; Divita Gilles
Kinetic mechanism of activation of the Cdk2/cyclin A complex. Key role of the C-lobe of the Cdk.
The Journal of biological chemistry 2002;277(26):23847-53.
2002: Barondeau David P; Kassmann Carey J; Tainer John A; Getzoff Elizabeth D
Structural chemistry of a green fluorescent protein Zn biosensor.
Journal of the American Chemical Society 2002;124(14):3522-4.
2002: Han Seungil; Tainer John A
The ARTT motif and a unified structural understanding of substrate recognition in ADP-ribosylating bacterial toxins and eukaryotic ADP-ribosyltransferases.
International journal of medical microbiology : IJMM 2002;291(6-7):523-9.
2002: Hopfner Karl Peter; Putnam Christopher D; Tainer John A
DNA double-strand break repair from head to tail.
Current opinion in structural biology 2002;12(1):115-22.
2002: Mol Clifford D; Arvai Andrew S; Begley Thomas J; Cunningham Richard P; Tainer John A
Structure and activity of a thermostable thymine-DNA glycosylase: evidence for base twisting to remove mismatched normal DNA bases.
Journal of molecular biology 2002;315(3):373-84.
2002: Adak Subrata; Bilwes Alexandrine M; Panda Koustubh; Hosfield David; Aulak Kulwant S; McDonald John F; Tainer John A; Getzoff Elizabeth D; Crane Brian R; Stuehr Dennis J
Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):107-12.
2002: Castagnetto Jesus M; Hennessy Sean W; Roberts Victoria A; Getzoff Elizabeth D; Tainer John A; Pique Michael E
MDB: the Metalloprotein Database and Browser at The Scripps Research Institute.
Nucleic acids research 2002;30(1):379-82.
2001: Aoyagi M; Arvai A S; Ghosh S; Stuehr D J; Tainer J A; Getzoff E D
Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457.
Biochemistry 2001;40(43):12826-32.
2001: Hearn A S; Stroupe M E; Cabelli D E; Lepock J R; Tainer J A; Nick H S; Silverman D N
Kinetic analysis of product inhibition in human manganese superoxide dismutase.
Biochemistry 2001;40(40):12051-8.
2001: Putnam C D; Clancy S B; Tsuruta H; Gonzalez S; Wetmur J G; Tainer J A
Structure and mechanism of the RuvB Holliday junction branch migration motor.
Journal of molecular biology 2001;311(2):297-310.
2001: Hopfner K P; Karcher A; Craig L; Woo T T; Carney J P; Tainer J A
Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase.
Cell 2001;105(4):473-85.
2001: Ayala B P; Vasquez B; Clary S; Tainer J A; Rodland K; So M
The pilus-induced Ca2+ flux triggers lysosome exocytosis and increases the amount of Lamp1 accessible to Neisseria IgA1 protease.
Cellular microbiology 2001;3(4):265-75.
2001: Chapados B R; Chai Q; Hosfield D J; Qiu J; Shen B; Tainer J A
Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication.
Journal of molecular biology 2001;307(2):541-56.
2001: Han S; Arvai A S; Clancy S B; Tainer J A
Crystal structure and novel recognition motif of rho ADP-ribosylating C3 exoenzyme from Clostridium botulinum: structural insights for recognition specificity and catalysis.
Journal of molecular biology 2001;305(1):95-107.
2001: Hosfield D J; Daniels D S; Mol C D; Putnam C D; Parikh S S; Tainer J A
DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes.
Progress in nucleic acid research and molecular biology 2001;68():315-47.
2000: Hopfner K P; Tainer J A
DNA mismatch repair: the hands of a genome guardian.
Structure (London, England : 1993) 2000;8(12):R237-41.
2000: Hopfner K P; Karcher A; Shin D; Fairley C; Tainer J A; Carney J P
Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine.
Journal of bacteriology 2000;182(21):6036-41.
2000: Mol C D; Hosfield D J; Tainer J A
Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means.
Mutation research 2000;460(3-4):211-29.
2000: Parikh S S; Putnam C D; Tainer J A
Lessons learned from structural results on uracil-DNA glycosylase.
Mutation research 2000;460(3-4):183-99.
2000: Daniels D S; Tainer J A
Conserved structural motifs governing the stoichiometric repair of alkylated DNA by O(6)-alkylguanine-DNA alkyltransferase.
Mutation research 2000;460(3-4):151-63.
2000: Hopfner K P; Karcher A; Shin D S; Craig L; Arthur L M; Carney J P; Tainer J A
Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily.
Cell 2000;101(7):789-800.
2000: Lévêque V J; Stroupe M E; Lepock J R; Cabelli D E; Tainer J A; Nick H S; Silverman D N
Multiple replacements of glutamine 143 in human manganese superoxide dismutase: effects on structure, stability, and catalysis.
Biochemistry 2000;39(24):7131-7.
2000: Parikh S S; Walcher G; Jones G D; Slupphaug G; Krokan H E; Blackburn G M; Tainer J A
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(10):5083-8.
2000: Crane B R; Arvai A S; Ghosh S; Getzoff E D; Stuehr D J; Tainer J A
Structures of the N(omega)-hydroxy-L-arginine complex of inducible nitric oxide synthase oxygenase dimer with active and inactive pterins.
Biochemistry 2000;39(16):4608-21.
2000: Daniels D S; Mol C D; Arvai A S; Kanugula S; Pegg A E; Tainer J A
Active and alkylated human AGT structures: a novel zinc site, inhibitor and extrahelical base binding.
The EMBO journal 2000;19(7):1719-30.
2000: Putnam C D; Arvai A S; Bourne Y; Tainer J A
Active and inhibited human catalase structures: ligand and NADPH binding and catalytic mechanism.
Journal of molecular biology 2000;296(1):295-309.
2000: Hopfner K P; Parikh S S; Tainer J A
Envisioning the fourth dimension of the genetic code: the structural biology of macromolecular recognition and conformational switching in DNA repair.
Cold Spring Harbor symposia on quantitative biology 2000;65():113-26.
1999: Crane B R; Rosenfeld R J; Arvai A S; Ghosh D K; Ghosh S; Tainer J A; Stuehr D J; Getzoff E D
N-terminal domain swapping and metal ion binding in nitric oxide synthase dimerization.
The EMBO journal 1999;18(22):6271-81.
1999: Ghosh D K; Crane B R; Ghosh S; Wolan D; Gachhui R; Crooks C; Presta A; Tainer J A; Getzoff E D; Stuehr D J
Inducible nitric oxide synthase: role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction.
The EMBO journal 1999;18(22):6260-70.
1999: Han S; Craig J A; Putnam C D; Carozzi N B; Tainer J A
Evolution and mechanism from structures of an ADP-ribosylating toxin and NAD complex.
Nature structural biology 1999;6(10):932-6.
1999: Cabelli D E; Guan Y; Leveque V; Hearn A S; Tainer J A; Nick H S; Silverman D N
Role of tryptophan 161 in catalysis by human manganese superoxide dismutase.
Biochemistry 1999;38(36):11686-92.
1999: Ramilo C A; Leveque V; Guan Y; Lepock J R; Tainer J A; Nick H S; Silverman D N
Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase.
The Journal of biological chemistry 1999;274(39):27711-6.
1999: Adak S; Crooks C; Wang Q; Crane B R; Tainer J A; Getzoff E D; Stuehr D J
Tryptophan 409 controls the activity of neuronal nitric-oxide synthase by regulating nitric oxide feedback inhibition.
The Journal of biological chemistry 1999;274(38):26907-11.
1999: Hosfield D J; Guan Y; Haas B J; Cunningham R P; Tainer J A
Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis.
Cell 1999;98(3):397-408.
1999: Ghosh S; Wolan D; Adak S; Crane B R; Kwon N S; Tainer J A; Getzoff E D; Stuehr D J
Mutational analysis of the tetrahydrobiopterin-binding site in inducible nitric-oxide synthase.
The Journal of biological chemistry 1999;274(34):24100-12.
1999: Pellequer J L; Chen S w; Roberts V A; Tainer J A; Getzoff E D
Unraveling the effect of changes in conformation and compactness at the antibody V(L)-V(H) interface upon antigen binding.
Journal of molecular recognition : JMR 1999;12(4):267-75.
1999: Bruns C M; Hubatsch I; Ridderström M; Mannervik B; Tainer J A
Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation products.
Journal of molecular biology 1999;288(3):427-39.
1999: Haas B J; Sandigursky M; Tainer J A; Franklin W A; Cunningham R P
Purification and characterization of Thermotoga maritima endonuclease IV, a thermostable apurinic/apyrimidinic endonuclease and 3'-repair diesterase.
Journal of bacteriology 1999;181(9):2834-9.
1999: Shroyer M J; Bennett S E; Putnam C D; Tainer J A; Mosbaugh D W
Mutation of an active site residue in Escherichia coli uracil-DNA glycosylase: effect on DNA binding, uracil inhibition and catalysis.
Biochemistry 1999;38(15):4834-45.
1999: Putnam C D; Shroyer M J; Lundquist A J; Mol C D; Arvai A S; Mosbaugh D W; Tainer J A
Protein mimicry of DNA from crystal structures of the uracil-DNA glycosylase inhibitor protein and its complex with Escherichia coli uracil-DNA glycosylase.
Journal of molecular biology 1999;287(2):331-46.
1999: Forest K T; Dunham S A; Koomey M; Tainer J A
Crystallographic structure reveals phosphorylated pilin from Neisseria: phosphoserine sites modify type IV pilus surface chemistry and fibre morphology.
Molecular microbiology 1999;31(3):743-52.
1999: Parikh S S; Mol C D; Hosfield D J; Tainer J A
Envisioning the molecular choreography of DNA base excision repair.
Current opinion in structural biology 1999;9(1):37-47.
1999: Mol C D; Parikh S S; Putnam C D; Lo T P; Tainer J A
DNA repair mechanisms for the recognition and removal of damaged DNA bases.
Annual review of biophysics and biomolecular structure 1999;28():101-28.
1998: Guan Y; Manuel R C; Arvai A S; Parikh S S; Mol C D; Miller J H; Lloyd S; Tainer J A
MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily.
Nature structural biology 1998;5(12):1058-64.
1998: Hosfield D J; Mol C D; Shen B; Tainer J A
Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Cell 1998;95(1):135-46.
1998: Hosfield D J; Frank G; Weng Y; Tainer J A; Shen B
Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1.
The Journal of biological chemistry 1998;273(42):27154-61.
1998: Parikh S S; Mol C D; Slupphaug G; Bharati S; Krokan H E; Tainer J A
Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.
The EMBO journal 1998;17(17):5214-26.
1998: Shen B; Qiu J; Hosfield D; Tainer J A
Flap endonuclease homologs in archaebacteria exist as independent proteins.
Trends in biochemical sciences 1998;23(5):171-3.
1998: Hsieh Y; Guan Y; Tu C; Bratt P J; Angerhofer A; Lepock J R; Hickey M J; Tainer J A; Nick H S; Silverman D N
Probing the active site of human manganese superoxide dismutase: the role of glutamine 143.
Biochemistry 1998;37(14):4731-9.
1998: Guan Y; Hickey M J; Borgstahl G E; Hallewell R A; Lepock J R; O'Connor D; Hsieh Y; Nick H S; Silverman D N; Tainer J A
Crystal structure of Y34F mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34.
Biochemistry 1998;37(14):4722-30.
1998: Crane B R; Arvai A S; Ghosh D K; Wu C; Getzoff E D; Stuehr D J; Tainer J A
Structure of nitric oxide synthase oxygenase dimer with pterin and substrate.
Science (New York, N.Y.) 1998;279(5359):2121-6.
1998: Marceau M; Forest K; Béretti J L; Tainer J; Nassif X
Consequences of the loss of O-linked glycosylation of meningococcal type IV pilin on piliation and pilus-mediated adhesion.
Molecular microbiology 1998;27(4):705-15.
1997: Parikh S S; Mol C D; Tainer J A
Base excision repair enzyme family portrait: integrating the structure and chemistry of an entire DNA repair pathway.
Structure (London, England : 1993) 1997;5(12):1543-50.
1997: Crane B R; Arvai A S; Gachhui R; Wu C; Ghosh D K; Getzoff E D; Stuehr D J; Tainer J A
The structure of nitric oxide synthase oxygenase domain and inhibitor complexes.
Science (New York, N.Y.) 1997;278(5337):425-31.
1997: Fisher C L; Cabelli D E; Hallewell R A; Beroza P; Lo T P; Getzoff E D; Tainer J A
Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase.
Proteins 1997;29(1):103-12.
1997: Forest K T; Tainer J A
Type-4 pilus-structure: outside to inside and top to bottom--a minireview.
Gene 1997;192(1):165-9.
1997: Boissinot M; Karnas S; Lepock J R; Cabelli D E; Tainer J A; Getzoff E D; Hallewell R A
Function of the Greek key connection analysed using circular permutants of superoxide dismutase.
The EMBO journal 1997;16(9):2171-8.
1996: Bourne Y; Redford S M; Steinman H M; Lepock J R; Tainer J A; Getzoff E D
Novel dimeric interface and electrostatic recognition in bacterial Cu,Zn superoxide dismutase.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(23):12774-9.
1996: Slupphaug G; Mol C D; Kavli B; Arvai A S; Krokan H E; Tainer J A
A nucleotide-flipping mechanism from the structure of human uracil-DNA glycosylase bound to DNA.
Nature 1996;384(6604):87-92.
1996: Mol C D; Harris J M; McIntosh E M; Tainer J A
Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits.
Structure (London, England : 1993) 1996;4(9):1077-92.
1996: Watson M H; Bourne Y; Arvai A S; Hickey M J; Santiago A; Bernstein S L; Tainer J A; Reed S I
A mutation in the human cyclin-dependent kinase interacting protein, CksHs2, interferes with cyclin-dependent kinase binding and biological function, but preserves protein structure and assembly.
Journal of molecular biology 1996;261(5):646-57.
1996: Kavli B; Slupphaug G; Mol C D; Arvai A S; Peterson S B; Tainer J A; Krokan H E
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase.
The EMBO journal 1996;15(13):3442-7.
1996: Borgstahl G E; Parge H E; Hickey M J; Johnson M J; Boissinot M; Hallewell R A; Lepock J R; Cabelli D E; Tainer J A
Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface.
Biochemistry 1996;35(14):4287-97.
1996: Bourne Y; Watson M H; Hickey M J; Holmes W; Rocque W; Reed S I; Tainer J A
Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.
Cell 1996;84(6):863-74.
1996: Forest K T; Bernstein S L; Getzoff E D; So M; Tribbick G; Geysen H M; Deal C D; Tainer J A
Assembly and antigenicity of the Neisseria gonorrhoeae pilus mapped with antibodies.
Infection and immunity 1996;64(2):644-52.
1995: Kuhn L A; Swanson C A; Pique M E; Tainer J A; Getzoff E D
Atomic and residue hydrophilicity in the context of folded protein structures.
Proteins 1995;23(4):536-47.
1995: Parge H E; Forest K T; Hickey M J; Christensen D A; Getzoff E D; Tainer J A
Structure of the fibre-forming protein pilin at 2.6 A resolution.
Nature 1995;378(6552):32-8.
1995: Bourne Y; Arvai A S; Bernstein S L; Watson M H; Reed S I; Endicott J E; Noble M E; Johnson L N; Tainer J A
Crystal structure of the cell cycle-regulatory protein suc1 reveals a beta-hinge conformational switch.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(22):10232-6.
1995: Mol C D; Arvai A S; Sanderson R J; Slupphaug G; Kavli B; Krokan H E; Mosbaugh D W; Tainer J A
Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA.
Cell 1995;82(5):701-8.
1995: Thayer M M; Ahern H; Xing D; Cunningham R P; Tainer J A
Novel DNA binding motifs in the DNA repair enzyme endonuclease III crystal structure.
The EMBO journal 1995;14(16):4108-20.
1995: Barzilay G; Mol C D; Robson C N; Walker L J; Cunningham R P; Tainer J A; Hickson I D
Identification of critical active-site residues in the multifunctional human DNA repair enzyme HAP1.
Nature structural biology 1995;2(7):561-8.
1995: Arvai A S; Bourne Y; Hickey M J; Tainer J A
Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain.
Journal of molecular biology 1995;249(5):835-42.
1995: McTigue M A; Bernstein S L; Williams D R; Tainer J A
Purification and crystallization of a schistosomal glutathione S-transferase.
Proteins 1995;22(1):55-7.
1995: Mol C D; Kuo C F; Thayer M M; Cunningham R P; Tainer J A
Structure and function of the multifunctional DNA-repair enzyme exonuclease III.
Nature 1995;374(6520):381-6.
1995: Mol C D; Arvai A S; Slupphaug G; Kavli B; Alseth I; Krokan H E; Tainer J A
Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis.
Cell 1995;80(6):869-78.
1995: McTigue M A; Williams D R; Tainer J A
Crystal structures of a schistosomal drug and vaccine target: glutathione S-transferase from Schistosoma japonica and its complex with the leading antischistosomal drug praziquantel.
Journal of molecular biology 1995;246(1):21-7.
1995: Tainer J A; Thayer M M; Cunningham R P
DNA repair proteins.
Current opinion in structural biology 1995;5(1):20-6.
1995: Arvai A S; Bourne Y; Williams D; Reed S I; Tainer J A
Crystallization and preliminary crystallographic study of human CksHs1: a cell cycle regulatory protein.
Proteins 1995;21(1):70-3.
1994: Kuo C F; Mol C D; Thayer M M; Cunningham R P; Tainer J A
Structure and function of the DNA repair enzyme exonuclease III from E. coli.
Annals of the New York Academy of Sciences 1994;726():223-34; discussion 234-5.
1994: Cunningham R P; Ahern H; Xing D; Thayer M M; Tainer J A
Structure and function of Escherichia coli endonuclease III.
Annals of the New York Academy of Sciences 1994;726():215-22.
1994: Fisher C L; Cabelli D E; Tainer J A; Hallewell R A; Getzoff E D
The role of arginine 143 in the electrostatics and mechanism of Cu,Zn superoxide dismutase: computational and experimental evaluation by mutational analysis.
Proteins 1994;19(1):24-34.
1993: Parge H E; Arvai A S; Murtari D J; Reed S I; Tainer J A
Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control.
Science (New York, N.Y.) 1993;262(5132):387-95.
1993: Tainer J A; Cunningham R P
Molecular recognition in DNA-binding proteins and enzymes.
Current opinion in biotechnology 1993;4(4):474-83.
1993: Boissinot M; Kuhn L A; Lee P; Fisher C L; Wang Y; Hallewell R A; Tainer J A
Rational design and expression of a heparin-targeted human superoxide dismutase.
Biochemical and biophysical research communications 1993;190(1):250-6.
1993: Kuo C F; McRee D E; Cunningham R P; Tainer J A
Purification, crystallization and space group determination of DNA repair enzyme exonuclease III from E. coli.
Journal of molecular biology 1993;229(1):239-42.
1992: Kuhn L A; Siani M A; Pique M E; Fisher C L; Getzoff E D; Tainer J A
The interdependence of protein surface topography and bound water molecules revealed by surface accessibility and fractal density measures.
Journal of molecular biology 1992;228(1):13-22.
1992: Kuo C F; McRee D E; Fisher C L; O'Handley S F; Cunningham R P; Tainer J A
Atomic structure of the DNA repair [4Fe-4S] enzyme endonuclease III.
Science (New York, N.Y.) 1992;258(5081):434-40.
1992: Borgstahl G E; Parge H E; Hickey M J; Beyer W F; Hallewell R A; Tainer J A
The structure of human mitochondrial manganese superoxide dismutase reveals a novel tetrameric interface of two 4-helix bundles.
Cell 1992;71(1):107-18.
1992: Kuo C F; McRee D E; Cunningham R P; Tainer J A
Crystallization and crystallographic characterization of the iron-sulfur-containing DNA-repair enzyme endonuclease III from Escherichia coli.
Journal of molecular biology 1992;227(1):347-51.
1992: Tainer J A; Roberts V A; Getzoff E D
Protein metal-binding sites.
Current opinion in biotechnology 1992;3(4):378-87.
1992: Parge H E; Hallewell R A; Tainer J A
Atomic structures of wild-type and thermostable mutant recombinant human Cu,Zn superoxide dismutase.
Proceedings of the National Academy of Sciences of the United States of America 1992;89(13):6109-13.
1991: Hallewell R A; Imlay K C; Lee P; Fong N M; Gallegos C; Getzoff E D; Tainer J A; Cabelli D E; Tekamp-Olson P; Mullenbach G T
Thermostabilization of recombinant human and bovine CuZn superoxide dismutases by replacement of free cysteines.
Biochemical and biophysical research communications 1991;181(1):474-80.
1991: Tainer J A; Roberts V A; Getzoff E D
Metal-binding sites in proteins.
Current opinion in biotechnology 1991;2(4):582-91.
1991: Roberts V A; Freeman H C; Olson A J; Tainer J A; Getzoff E D
Electrostatic orientation of the electron-transfer complex between plastocyanin and cytochrome c.
The Journal of biological chemistry 1991;266(20):13431-41.
1991: Nachman R J; Roberts V A; Dyson H J; Holman G M; Tainer J A
Active conformation of an insect neuropeptide family.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(10):4518-22.
1991: Tainer J A; Deal C D; Geysen H M; Roberts V A; Getzoff E D
Defining antibody-antigen recognition: towards engineered antibodies and epitopes.
International reviews of immunology 1991;7(2):165-88.
1991: Fisher C L; Hallewell R A; Roberts V A; Tainer J A; Getzoff E D
Probing the structural basis for enzyme-substrate recognition in Cu,Zn superoxide dismutase.
Free radical research communications 1991;12-13 Pt 1():287-96.
1991: Roberts V A; Fisher C L; Redford S M; McRee D E; Parge H E; Getzoff E D; Tainer J A
Mechanism and atomic structure of superoxide dismutase.
Free radical research communications 1991;12-13 Pt 1():269-78.
1990: Kuhn L A; Griffin J H; Fisher C L; Greengard J S; Bouma B N; España F; Tainer J A
Elucidating the structural chemistry of glycosaminoglycan recognition by protein C inhibitor.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(21):8506-10.
1990: Roberts V A; Iverson B L; Iverson S A; Benkovic S J; Lerner R A; Getzoff E D; Tainer J A
Antibody remodeling: a general solution to the design of a metal-coordination site in an antibody binding pocket.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(17):6654-8.
1990: Fisher C L; Tainer J A; Pique M E; Getzoff E D
Visualization of molecular flexibility and its effects on electrostatic recognition.
Journal of molecular graphics 1990;8(3):125-32, 145.
1990: McRee D E; Redford S M; Getzoff E D; Lepock J R; Hallewell R A; Tainer J A
Changes in crystallographic structure and thermostability of a Cu,Zn superoxide dismutase mutant resulting from the removal of a buried cysteine.
The Journal of biological chemistry 1990;265(24):14234-41.
1990: Iverson B L; Iverson S A; Roberts V A; Getzoff E D; Tainer J A; Benkovic S J; Lerner R A
Metalloantibodies.
Science (New York, N.Y.) 1990;249(4969):659-62.
1990: Redford S M; McRee D E; Getzoff E D; Steinman H M; Tainer J A
Crystallographic characterization of a Cu,Zn superoxide dismutase from Photobacterium leiognathi.
Journal of molecular biology 1990;212(3):449-51.
1989: McRee D E; Tainer J A; Meyer T E; Van Beeumen J; Cusanovich M A; Getzoff E D
Crystallographic structure of a photoreceptor protein at 2.4 A resolution.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(17):6533-7.
1989: Hallewell R A; Laria I; Tabrizi A; Carlin G; Getzoff E D; Tainer J A; Cousens L S; Mullenbach G T
Genetically engineered polymers of human CuZn superoxide dismutase. Biochemistry and serum half-lives.
The Journal of biological chemistry 1989;264(9):5260-8.
1988: Mullenbach G T; Tabrizi A; Irvine B D; Bell G I; Tainer J A; Hallewell R A
Selenocysteine's mechanism of incorporation and evolution revealed in cDNAs of three glutathione peroxidases.
Protein engineering 1988;2(3):239-46.
1988: Getzoff E D; Parge H E; McRee D E; Tainer J A
Understanding the structure and antigenicity of gonococcal pili.
Reviews of infectious diseases 1988;10 Suppl 2():S296-9.
1988: Tainer J A; Hallewell R A; Roberts V A; Parge H E; Getzoff E D
Probing enzyme-substrate recognition and catalytic mechanism in Cu,Zn superoxide dismutase.
Basic life sciences 1988;49():635-40.
1988: Getzoff E D; Tainer J A; Lerner R A; Geysen H M
The chemistry and mechanism of antibody binding to protein antigens.
Advances in immunology 1988;43():1-98.
1987: Fieser T M; Tainer J A; Geysen H M; Houghten R A; Lerner R A
Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein alpha-helix.
Proceedings of the National Academy of Sciences of the United States of America 1987;84(23):8568-72.
1987: Parge H E; McRee D E; Capozza M A; Bernstein S L; Getzoff E D; Tainer J A
Three dimensional structure of bacterial pili.
Antonie van Leeuwenhoek 1987;53(6):447-53.
1986: Parge H E; Getzoff E D; Scandella C S; Hallewell R A; Tainer J A
Crystallographic characterization of recombinant human CuZn superoxide dismutase.
The Journal of biological chemistry 1986;261(34):16215-8.

Sign-in to see more