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Haruhiko Takada

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Tomoko Ikeuchi; Takashi Nakamura; Satoshi Fukumoto; Haruhiko Takada
A vitamin D3 analog augmented interleukin-8 production by human monocytic cells in response to various microbe-related synthetic ligands, especially NOD2 agonistic muramyldipeptide.
Ling Huang; Masayuki Kinbara; Shunji Sugawara; Haruhiko Takada; Hiromi Funayama; Yasuo Endo
The elicitation step of nickel allergy is promoted in mice by microbe-related substances, including some from oral bacteria.
Tadasu Sato; Yosuke Shikama; Hidetoshi Shimauchi; Yasuo Endo; Haruhiko Takada
Analgesic effects of chemically synthesized NOD1 and NOD2 agonists in mice.

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2013: Tomoko Ikeuchi; Takashi Nakamura; Satoshi Fukumoto; Haruhiko Takada
A vitamin D3 analog augmented interleukin-8 production by human monocytic cells in response to various microbe-related synthetic ligands, especially NOD2 agonistic muramyldipeptide.
International immunopharmacology 2013;15(1):15-22.
2011: Ling Huang; Masayuki Kinbara; Shunji Sugawara; Haruhiko Takada; Hiromi Funayama; Yasuo Endo
The elicitation step of nickel allergy is promoted in mice by microbe-related substances, including some from oral bacteria.
International immunopharmacology 2011;11(11):1916-24.
2011: Tadasu Sato; Yosuke Shikama; Hidetoshi Shimauchi; Yasuo Endo; Haruhiko Takada
Analgesic effects of chemically synthesized NOD1 and NOD2 agonists in mice.
Innate immunity 2011;17(1):54-9.
2011: Yosuke Shikama; Toshinobu Kuroishi; Yasuhiro Nagai; Yoichiro Iwakura; Hidetoshi Shimauchi; Haruhiko Takada; Shunji Sugawara; Yasuo Endo
Muramyldipeptide augments the actions of lipopolysaccharide in mice by stimulating macrophages to produce pro-IL-1β and by down-regulation of the suppressor of cytokine signaling 1 (SOCS1).
Innate immunity 2011;17(1):3-15.
2010: Naoki Sato; Takefumi Oizumi; Masayuki Kinbara; Tadasu Sato; Hiromi Funayama; Seiji Sato; Kazuhiro Matsuda; Haruhiko Takada; Shunji Sugawara; Yasuo Endo
Promotion of arthritis and allergy in mice by aminoglycoglycerophospholipid, a membrane antigen specific to Mycoplasma fermentans.
FEMS immunology and medical microbiology 2010;59(1):33-41.
2008: Mizuho Natsuka; Akiko Uehara; Shuhua Yang; Seishi Echigo; Haruhiko Takada
A polymer-type water-soluble peptidoglycan exhibited both Toll-like receptor 2- and NOD2-agonistic activities, resulting in synergistic activation of human monocytic cells.
Innate immunity 2008;14(5):298-308.
2008: Akiko Uehara; Haruhiko Takada
Synergism between TLRs and NOD1/2 in oral epithelial cells.
Journal of dental research 2008;87(7):682-6.
2008: Akiko Uehara; Yasuhiko Hirabayashi; Haruhiko Takada
Antibodies to proteinase 3 prime human oral, lung, and kidney epithelial cells to secrete proinflammatory cytokines upon stimulation with agonists to various Toll-like receptors, NOD1, and NOD2.
Clinical and vaccine immunology : CVI 2008;15(7):1060-6.
2008: Akiko Uehara; Mariko Naito; Takahisa Imamura; Jan Potempa; James Travis; Koji Nakayama; Haruhiko Takada
Dual regulation of interleukin-8 production in human oral epithelial cells upon stimulation with gingipains from Porphyromonas gingivalis.
Journal of medical microbiology 2008;57(Pt 4):500-7.
2007: Akiko Uehara; Atsushi Iwashiro; Tadasu Sato; Sou Yokota; Haruhiko Takada
Antibodies to proteinase 3 prime human monocytic cells via protease-activated receptor-2 and NF-kappaB for Toll-like receptor- and NOD-dependent activation.
Molecular immunology 2007;44(14):3552-62.
2007: Akiko Uehara; Yukari Fujimoto; Koichi Fukase; Haruhiko Takada
Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines.
Molecular immunology 2007;44(12):3100-11.
2007: Akiko Uehara; Haruhiko Takada
Functional TLRs and NODs in human gingival fibroblasts.
Journal of dental research 2007;86(3):249-54.
2006: Akiko Uehara; Yukari Fujimoto; Akiko Kawasaki; Shoichi Kusumoto; Koichi Fukase; Haruhiko Takada
Meso-diaminopimelic acid and meso-lanthionine, amino acids specific to bacterial peptidoglycans, activate human epithelial cells through NOD1.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(3):1796-804.
2006: Haruhiko Takada; Akiko Uehara
Enhancement of TLR-mediated innate immune responses by peptidoglycans through NOD signaling.
Current pharmaceutical design 2006;12(32):4163-72.
2005: Hiroyuki Tada; Setsuya Aiba; Ken-Ichiro Shibata; Toshiaki Ohteki; Haruhiko Takada
Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells.
Infection and immunity 2005;73(12):7967-76.
2005: Akiko Uehara; Koji Muramoto; Takahisa Imamura; Koji Nakayama; Jan Potempa; James Travis; Shunji Sugawara; Haruhiko Takada
Arginine-specific gingipains from Porphyromonas gingivalis stimulate production of hepatocyte growth factor (scatter factor) through protease-activated receptors in human gingival fibroblasts in culture.
Journal of immunology (Baltimore, Md. : 1950) 2005;175(9):6076-84.
2005: Akiko Uehara; Y Sugawara; S Kurata; Yukari Fujimoto; Koichi Fukase; Shoichi Kusumoto; Y Satta; T Sasano; Shunji Sugawara; Haruhiko Takada
Chemically synthesized pathogen-associated molecular patterns increase the expression of peptidoglycan recognition proteins via toll-like receptors, NOD1 and NOD2 in human oral epithelial cells.
Cellular microbiology 2005;7(5):675-86.
2005: Akiko Uehara; Shuhua Yang; Yukari Fujimoto; Koichi Fukase; Shoichi Kusumoto; K Shibata; Shunji Sugawara; Haruhiko Takada
Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture.
Cellular microbiology 2005;7(1):53-61.
2004: Fumiaki Shinohara; Keiko Sato; Maiko Suzuki; Haruhiko Takada; Seishi Echigo; Hidemi Rikiishi
Role of caspase in CD80 expression of superantigen-stimulated monocytes.
International journal of molecular medicine 2004;14(2):241-6.
2004: Keiko Sato; Takahiro Taniguchi; Maiko Suzuki; Fumiaki Shinohara; Haruhiko Takada; Hidemi Rikiishi
Dual role of NF-kappaB in apoptosis of THP-1 cells during treatment with etoposide and lipopolysaccharide.
Leukemia research 2004;28(1):63-9.
2003: Hiroyuki Tada; Shunji Sugawara; Eiji Nemoto; Takahisa Imamura; Jan Potempa; James Travis; Hidetoshi Shimauchi; Haruhiko Takada
Proteolysis of ICAM-1 on human oral epithelial cells by gingipains.
Journal of dental research 2003;82(10):796-801.
2003: Akiko Ozawa; Hiroyuki Tada; Riyoko Tamai; Akiko Uehara; Kouichi Watanabe; Takahiro Yamaguchi; Hidetoshi Shimauchi; Haruhiko Takada; Shunji Sugawara
Expression of IL-2 receptor beta and gamma chains by human gingival fibroblasts and up-regulation of adhesion to neutrophils in response to IL-2.
Journal of leukocyte biology 2003;74(3):352-9.
2003: Akiko Uehara; Shunji Sugawara; Kouichi Watanabe; Seishi Echigo; Mitsunobu Sato; Takahiro Yamaguchi; Haruhiko Takada
Constitutive expression of a bacterial pattern recognition receptor, CD14, in human salivary glands and secretion as a soluble form in saliva.
Clinical and diagnostic laboratory immunology 2003;10(2):286-92.
2003: Maiko Suzuki; Fumiaki Shinohara; Keiko Sato; Takahiro Taniguchi; Haruhiko Takada; Hidemi Rikiishi
Interleukin-1beta converting enzyme subfamily inhibitors prevent induction of CD86 molecules by butyrate through a CREB-dependent mechanism in HL60 cells.
Immunology 2003;108(3):375-83.
2003: Riyoko Tamai; Shunji Sugawara; Osamu Takeuchi; Shizuo Akira; Haruhiko Takada
Synergistic effects of lipopolysaccharide and interferon-gamma in inducing interleukin-8 production in human monocytic THP-1 cells is accompanied by up-regulation of CD14, Toll-like receptor 4, MD-2 and MyD88 expression.
Journal of endotoxin research 2003;9(3):145-53.
2002: Akiko Uehara; Shunji Sugawara; Haruhiko Takada
Priming of human oral epithelial cells by interferon-gamma to secrete cytokines in response to lipopolysaccharides, lipoteichoic acids and peptidoglycans.
Journal of medical microbiology 2002;51(8):626-34.
2002: Hiroyuki Tada; Shunji Sugawara; Eiji Nemoto; Nobuhiro Takahashi; Takahisa Imamura; Jan Potempa; James Travis; Hidetoshi Shimauchi; Haruhiko Takada
Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production.
Infection and immunity 2002;70(6):3304-7.
2002: Riyoko Tamai; Tetsuya Sakuta; Kenji Matsushita; Mitsuo Torii; Osamu Takeuchi; Shizuo Akira; Sachiko Akashi; Terje Espevik; Shunji Sugawara; Haruhiko Takada
Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression.
Infection and immunity 2002;70(3):1272-8.
2002: Shunji Sugawara; Akiko Uehara; Riyoko Tamai; Haruhiko Takada
Innate immune responses in oral mucosa.
Journal of endotoxin research 2002;8(6):465-8.
2002: Haruhiko Takada; Shigekuni Yokoyama; Shuhua Yang
Enhancement of endotoxin activity by muramyldipeptide.
Journal of endotoxin research 2002;8(5):337-42.
2002: Hiroyuki Tada; Eiji Nemoto; Hidetoshi Shimauchi; Toshihiko Watanabe; Takeshi Mikami; Tatsuji Matsumoto; Naohito Ohno; Hiroshi Tamura; Ken-ichiro Shibata; Sachiko Akashi; Kensuke Miyake; Shunji Sugawara; Haruhiko Takada
Saccharomyces cerevisiae- and Candida albicans-derived mannan induced production of tumor necrosis factor alpha by human monocytes in a CD14- and Toll-like receptor 4-dependent manner.
Microbiology and immunology 2002;46(7):503-12.
2002: A Sugiyama; Akiko Uehara; K Iki; K Matsushita; R Nakamura; T Ogawa; Shunji Sugawara; Haruhiko Takada
Activation of human gingival epithelial cells by cell-surface components of black-pigmented bacteria: augmentation of production of interleukin-8, granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor and expression of intercellular adhesion molecule 1.
Journal of medical microbiology 2002;51(1):27-33.
2001: Akiko Uehara; Shunji Sugawara; Riyoko Tamai; Haruhiko Takada
Contrasting responses of human gingival and colonic epithelial cells to lipopolysaccharides, lipoteichoic acids and peptidoglycans in the presence of soluble CD14.
Medical microbiology and immunology 2001;189(4):185-92.
2001: Shunji Sugawara; Shuhua Yang; K Iki; J Hatakeyama; Riyoko Tamai; Osamu Takeuchi; Sachiko Akashi; Terje Espevik; Shizuo Akira; Haruhiko Takada
Monocytic cell activation by Nonendotoxic glycoprotein from Prevotella intermedia ATCC 25611 is mediated by toll-like receptor 2.
Infection and immunity 2001;69(8):4951-7.
2001: Masato Takahashi; M Takahashi; Fumiaki Shinohara; Haruhiko Takada; Hidemi Rikiishi
Effects of superantigen and lipopolysaccharide on induction of CD80 through apoptosis of human monocytes.
Infection and immunity 2001;69(6):3652-7.
2001: Shuhua Yang; Riyoko Tamai; Sachiko Akashi; Osamu Takeuchi; Shizuo Akira; Shunji Sugawara; Haruhiko Takada
Synergistic effect of muramyldipeptide with lipopolysaccharide or lipoteichoic acid to induce inflammatory cytokines in human monocytic cells in culture.
Infection and immunity 2001;69(4):2045-53.
2001: Shuhua Yang; Shunji Sugawara; T Monodane; M Nishijima; Y Adachi; Sachiko Akashi; Kensuke Miyake; S Hase; Haruhiko Takada
Micrococcus luteus teichuronic acids activate human and murine monocytic cells in a CD14- and toll-like receptor 4-dependent manner.
Infection and immunity 2001;69(4):2025-30.
2001: Tetsuya Sakuta; Kakushi Matsushita; N Yamaguchi; Tohru Oyama; R Motani; T Koga; Shigetaka Nagaoka; Kazuhiro Abeyama; Ikuro Maruyama; Haruhiko Takada; Mitsuo Torii
Enhanced production of vascular endothelial growth factor by human monocytic cells stimulated with endotoxin through transcription factor SP-1.
Journal of medical microbiology 2001;50(3):233-7.
2001: T Monodane; Y Kawabata; Shuhua Yang; S Hase; Haruhiko Takada
Induction of necrosis factor-alpha and interleukin-6 in mice in vivo and in murine peritoneal macrophages and human whole blood cells in vitro by Micrococcus luteus teichuronic acids.
Journal of medical microbiology 2001;50(1):4-12.
2000: Eiji Nemoto; Shunji Sugawara; Hiroyuki Tada; Haruhiko Takada; Hidetoshi Shimauchi; H Horiuchi
Cleavage of CD14 on human gingival fibroblasts cocultured with activated neutrophils is mediated by human leukocyte elastase resulting in down-regulation of lipopolysaccharide-induced IL-8 production.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5807-13.
2000: Y Kawabata; T S Yang; T T Yokochi; M Matsushita; T Fujita; M Shibazaki; T Noikura; T Y Endo; Haruhiko Takada
Complement system is involved in anaphylactoid reaction induced by lipopolysaccharides in muramyldipeptide-treated mice.
Shock (Augusta, Ga.) 2000;14(5):572-7.
2000: Shunji Sugawara; Eiji Nemoto; Hiroyuki Tada; Kensuke Miyake; Takahisa Imamura; Haruhiko Takada
Proteolysis of human monocyte CD14 by cysteine proteinases (gingipains) from Porphyromonas gingivalis leading to lipopolysaccharide hyporesponsiveness.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(1):411-8.
2000: A Sugiyama; T Ogawa; Y Daikuhara; Haruhiko Takada
Enhancement of hepatocyte growth factor (scatter factor) production by human gingival fibroblasts in culture stimulated with Porphyromonas gingivalis fimbriae.
Journal of medical microbiology 2000;49(4):319-25.
1999: Kenji Matsushita; T Tajima; K Tomita; Haruhiko Takada; Shigetaka Nagaoka; Mitsuo Torii
Inflammatory cytokine production and specific antibody responses to lipopolysaccharide from endodontopathic black-pigmented bacteria in patients with multilesional periapical periodontitis.
Journal of endodontics 1999;25(12):795-9.
1999: Kakushi Matsushita; R Motani; Tetsuya Sakuta; Shigetaka Nagaoka; Takami Matsuyama; Kazuhiro Abeyama; Ikuro Maruyama; Haruhiko Takada; Mitsuo Torii
Lipopolysaccharide enhances the production of vascular endothelial growth factor by human pulp cells in culture.
Infection and immunity 1999;67(4):1633-9.
1999: Shunji Sugawara; R Arakaki; Hidemi Rikiishi; Haruhiko Takada
Lipoteichoic acid acts as an antagonist and an agonist of lipopolysaccharide on human gingival fibroblasts and monocytes in a CD14-dependent manner.
Infection and immunity 1999;67(4):1623-32.
1998: Kenji Matsushita; T Tajima; K Tomita; Kazuhiro Abeyama; Ikuro Maruyama; Haruhiko Takada; Shigetaka Nagaoka
Inflammatory cytokine production and specific antibody responses against possible causative bacteria in patients with multilesional periapical periodontitis.
Journal of endodontics 1998;24(12):817-21.
1998: Y Kawabata; Ichiro Semba; Yoshikazu Hirayama; T Koga; S Nagao; Haruhiko Takada
Wax D of Mycobacterium tuberculosis induced osteomyelitis accompanied by reactive bone formation in Buffalo rats.
FEMS immunology and medical microbiology 1998;22(4):293-302.
1998: R Arakaki; S Sugawara; H Nakashima; S Kotani; Haruhiko Takada
A lipoteichoic acid fraction of Enterococcus hirae activates cultured human monocytic cells via a CD14-independent pathway to promote cytokine production, and the activity is inhibited by serum components.
FEMS immunology and medical microbiology 1998;22(4):283-91.
1998: Tetsuya Sakuta; Masayuki Tokuda; M Tamura; E Jimi; T Ikebe; T Koba; Shigetaka Nagaoka; Haruhiko Takada
Dual regulatory effects of interferon-alpha, -beta, and -gamma on interleukin-8 gene expression by human gingival fibroblasts in culture upon stimulation with lipopolysaccharide from Prevotella intermedia, interleukin-1alpha, or tumor necrosis factor-alpha.
Journal of dental research 1998;77(8):1597-605.
1998: Shunji Sugawara; A Sugiyama; Eiji Nemoto; Hidemi Rikiishi; Haruhiko Takada
Heterogeneous expression and release of CD14 by human gingival fibroblasts: characterization and CD14-mediated interleukin-8 secretion in response to lipopolysaccharide.
Infection and immunity 1998;66(7):3043-9.
1997: K Iki; K Kawahara; S Sawamura; R Arakaki; Tetsuya Sakuta; A Sugiyama; H Tamura; T Sueda; S Hamada; Haruhiko Takada
A novel component different from endotoxin extracted from Prevotella intermedia ATCC 25611 activates lymphoid cells from C3H/HeJ mice and gingival fibroblasts from humans.
Infection and immunity 1997;65(11):4531-8.
1997: Kakushi Matsushita; T Uchiyama; H Igarashi; Hisashi Ohkuni; S Nagaoka; S Kotani; Haruhiko Takada
Possible pathogenic effect of Streptococcus mitis superantigen on oral epithelial cells.
Advances in experimental medicine and biology 1997;418():685-8.
1997: T Monodane; Y Kawabata; Haruhiko Takada
Micrococcus luteus cells and cell walls induce anaphylactoid reactions accompanied by early death and serum cytokines in mice primed with muramyl dipeptide.
FEMS immunology and medical microbiology 1997;17(1):49-55.
1996: A Sugiyama; R Arakaki; Tomokazu Ohnishi; N Arakaki; Yasushi Daikuhara; Haruhiko Takada
Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture.
Infection and immunity 1996;64(4):1426-31.
1996: K Matsushita; A Sugiyama; T Uchiyama; H Igarashi; Hisashi Ohkuni; Shigetaka Nagaoka; S Kotani; Haruhiko Takada
Induction of lymphocytes cytotoxic to oral epithelial cells by Streptococcus mitis superantigen.
Journal of dental research 1996;75(3):927-34.
1996: Haruhiko Takada; Y Kawabata; S Kawata; S Kusumoto
Structural characteristics of peptidoglycan fragments required to prime mice for induction of anaphylactoid reactions by lipopolysaccharides.
Infection and immunity 1996;64(2):657-9.
1996: Shigetaka Nagaoka; M Tokuda; Tetsuya Sakuta; Y Taketoshi; M Tamura; Haruhiko Takada; M Kawagoe
Interleukin-8 gene expression by human dental pulp fibroblast in cultures stimulated with Prevotella intermedia lipopolysaccharide.
Journal of endodontics 1996;22(1):9-12.
1995: S Nagao; Y Kawabata; M Kitano; K Suzuki; T Nishikawa; Haruhiko Takada
Modification of delayed-type hypersensitivity reactions by muramyldipeptide in guinea pigs.
FEMS immunology and medical microbiology 1995;11(3):231-45.
1995: K Matsushita; W Fujimaki; H Kato; T Uchiyama; H Igarashi; Hisashi Ohkuni; Shigetaka Nagaoka; M Kawagoe; S Kotani; Haruhiko Takada
Immunopathological activities of extracellular products of Streptococcus mitis, particularly a superantigenic fraction.
Infection and immunity 1995;63(3):785-93.
1995: S Nagao; Y Kawabata; T Nishikawa; Haruhiko Takada
Endotoxin induces severe inflammatory reactions with necrosis at sites primed with delayed-type hypersensitivity reactions in guinea pigs.
Microbiology and immunology 1995;39(12):1011-14.
1995: Haruhiko Takada; K Iki; Tetsuya Sakuta; A Sugiyama; S Sawamura; S Hamada
Lipopolysaccharides of oral black pigmented bacteria and periodontal diseases. A novel immunomodulator different from endotoxin was extracted from Prevotella intermedia ATCC 25611 with hot phenol-water.
Progress in clinical and biological research 1995;392():59-68.
1995: Haruhiko Takada; Y Kawabata; R Arakaki; S Kusumoto; Koichi Fukase; Y Suda; T Yoshimura; S Kokeguchi; K Kato; T Komuro
Molecular and structural requirements of a lipoteichoic acid from Enterococcus hirae ATCC 9790 for cytokine-inducing, antitumor, and antigenic activities.
Infection and immunity 1995;63(1):57-65.
1994: Y Kawabata; S Nagao; T Asano; T Nishikawa; Haruhiko Takada
Guinea pigs prepared with various bacteria and their components to induce a necrotic reaction provoked with muramyldipeptide.
FEMS immunology and medical microbiology 1994;9(4):287-97.
1994: K Matsushita; Shigetaka Nagaoka; R Arakaki; Y Kawabata; K Iki; M Kawagoe; Haruhiko Takada
Immunobiological activities of a 55-kilodalton cell surface protein of Prevotella intermedia ATCC 25611.
Infection and immunity 1994;62(6):2459-69.
1993: Haruhiko Takada; Y Kawabata; M Tamura; K Matsushita; H Igarashi; Hisashi Ohkuni; Yuko Todome; T Uchiyama; S Kotani
Cytokine induction by extracellular products of oral viridans group streptococci.
Infection and immunity 1993;61(12):5252-60.
1993: M Tamura; N Arakaki; H Tsubouchi; Haruhiko Takada; Yasushi Daikuhara
Enhancement of human hepatocyte growth factor production by interleukin-1 alpha and -1 beta and tumor necrosis factor-alpha by fibroblasts in culture.
The Journal of biological chemistry 1993;268(11):8140-5.
1992: M Tamura; M Tokuda; Shigetaka Nagaoka; Haruhiko Takada
Lipopolysaccharides of Bacteroides intermedius (Prevotella intermedia) and Bacteroides (Porphyromonas) gingivalis induce interleukin-8 gene expression in human gingival fibroblast cultures.
Infection and immunity 1992;60(11):4932-7.