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Tappei Takada

Research Profile

Chemicals & Drugs

Physiology

Disorders

Hyperuricemia

Anatomy

Living Beings

Rats

Genes & Molecular Sequences

Single Nucleotide Polymorphism

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Publications

TOP 3
Takashi Yoshikado; Kousei Ito; Tomofumi Santa; Tappei Takada; Jeng Kae Tan; Hideaki Yamamoto; Hiroshi Suzuki
Ticlopidine, a cholestatic liver injury-inducible drug, causes dysfunction of bile formation via diminished biliary secretion of phospholipids: involvement of biliary-excreted glutathione-conjugated ticlopidine metabolites.
Masanori Ito; Hiroko Izumi-Nakaseko; Masaru Kuroda; Satoko Oda; Atsushi Sugiyama; Hiroshi Suzuki; Tappei Takada; Yu Toyoda; Yoshihide Yamanashi; Satomi Adachi-Akahane
Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis.
Tappei Takada
[Transporter-mediated regulation of pharmacokinetics of lifestyle-related substances].

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2013: Takashi Yoshikado; Kousei Ito; Tomofumi Santa; Tappei Takada; Jeng Kae Tan; Hideaki Yamamoto; Hiroshi Suzuki
Ticlopidine, a cholestatic liver injury-inducible drug, causes dysfunction of bile formation via diminished biliary secretion of phospholipids: involvement of biliary-excreted glutathione-conjugated ticlopidine metabolites.
Molecular pharmacology 2013;83(2):552-62.
2013: Masanori Ito; Hiroko Izumi-Nakaseko; Masaru Kuroda; Satoko Oda; Atsushi Sugiyama; Hiroshi Suzuki; Tappei Takada; Yu Toyoda; Yoshihide Yamanashi; Satomi Adachi-Akahane
Disruption of Stard10 gene alters the PPARα-mediated bile acid homeostasis.
Biochimica et biophysica acta 2013;1831(2):459-68.
2013: Tappei Takada
[Transporter-mediated regulation of pharmacokinetics of lifestyle-related substances].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2013;133(4):451-61.
2012: Yuki Ikebuchi; Kousei Ito; Hidetoshi Shimizu; Tappei Takada; Yoshihide Yamanashi; Takashi Yoshikado; Hiroshi Suzuki
Ursodeoxycholic acid stimulates the formation of the bile canalicular network.
Biochemical pharmacology 2012;84(7):925-35.
2012: Yoshihide Yamanashi; Tappei Takada; Jun-Ichi Shoda; Hiroshi Suzuki
Novel function of Niemann-Pick C1-like 1 as a negative regulator of Niemann-Pick C2 protein.
Hepatology (Baltimore, Md.) 2012;55(3):953-64.
2012: Tappei Takada; Yoshihide Yamanashi; Hiroshi Suzuki
[Transportsome in biliary cholesterol secretion].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2012;139(2):56-60.
2012: Kimiyoshi Ichida; Yuki Ikebuchi; Hiroki Inoue; Kousei Ito; Hiroshi Kasuga; Yusuke Kawamura; Hirotaka Matsuo; Keizo Murakami; Makiko Nakamura; Takahiro Nakamura; Hiroshi Nakashima; Akiyoshi Nakayama; Chisa Okada; Yutaka Sakurai; Toru Shimizu; Yoshihiko Shinohara; Nariyoshi Shinomiya; Tappei Takada; Yuzo Takada; Yoshitaka Utsumi; Yoshihide Yamanashi; Tatsuo Hosoya; Makoto Hosoyamada; Hiroshi Suzuki
Decreased extra-renal urate excretion is a common cause of hyperuricemia.
Nature communications 2012;3():764.
2011: Tappei Takada; Hirotaka Matsuo
[Urate exporter gene ABCG 2/BCRP and gout risk].
Seikagaku. The Journal of Japanese Biochemical Society 2011;83(12):1131-5.
2011: Hirotaka Matsuo; Takahiro Nakamura; Akiyoshi Nakayama; Tatsuo Hosoya; Kimiyoshi Ichida; Hiroshi Suzuki; Tappei Takada; Nariyoshi Shinomiya
ABCG2/BCRP dysfunction as a major cause of gout.
Nucleosides, nucleotides & nucleic acids 2011;30(12):1117-28.
2011: H Matsuo; T Nakamura; A Nakayama; C Okada; Y Sakurai; T Hosoya; K Ichida; Y Kanai; H Suzuki; Tappei Takada; Y Takada; Nariyoshi Shinomiya
Identification of ABCG2 dysfunction as a major factor contributing to gout.
Nucleosides, nucleotides & nucleic acids 2011;30(12):1098-104.
2011: Akiyoshi Nakayama; Hiroshi Suzuki; Tappei Takada; Tatsuo Hosoya; Kimiyoshi Ichida; Yuki Ikebuchi; Kousei Ito; Yoshikatsu Kanai; Hirotaka Matsuo; Takahiro Nakamura; Nariyoshi Shinomiya
ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans.
Nucleosides, nucleotides & nucleic acids 2011;30(12):1091-7.
2011: Yoshihide Yamanashi; Tappei Takada; Takashi Yoshikado; Jun-Ichi Shoda; Hiroshi Suzuki
NPC2 regulates biliary cholesterol secretion via stimulation of ABCG5/G8-mediated cholesterol transport.
Gastroenterology 2011;140(5):1664-74.
2011: Takashi Yoshikado; Tappei Takada; Takehito Yamamoto; Hiroko Yamaji; Kousei Ito; Tomofumi Santa; Hiromitsu Yokota; Yutaka Yatomi; Haruhiko Yoshida; Jun Goto; Shoji Tsuji; Hiroshi Suzuki
Itraconazole-induced cholestasis: involvement of the inhibition of bile canalicular phospholipid translocator MDR3/ABCB4.
Molecular pharmacology 2011;79(2):241-50.
2011: Yuki Iwayanagi; Tappei Takada; Fumiya Tomura; Yoshihide Yamanashi; Tomohiro Terada; Ken-ichi Inui; Hiroshi Suzuki
Human NPC1L1 expression is positively regulated by PPARα.
Pharmaceutical research 2011;28(2):405-12.
2010: Yuki Ikebuchi; Kousei Ito; Tappei Takada; Naohiko Anzai; Yoshikatsu Kanai; Hiroshi Suzuki
Receptor for activated C-kinase 1 regulates the cell surface expression and function of ATP binding cassette G2.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(12):2320-8.
2010: Tappei Takada; Hiroshi Suzuki
Molecular mechanisms of membrane transport of vitamin E.
Molecular nutrition & food research 2010;54(5):616-22.
2009: Yoshihide Yamanashi; Tappei Takada; Hiroshi Suzuki
In-vitro characterization of the six clustered variants of NPC1L1 observed in cholesterol low absorbers.
Pharmacogenetics and genomics 2009;19(11):884-92.
2009: Yuki Ikebuchi; Tappei Takada; Kousei Ito; Takashi Yoshikado; Naohiko Anzai; Yoshikatsu Kanai; Hiroshi Suzuki
Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4.
Hepatology research : the official journal of the Japan Society of Hepatology 2009;39(11):1091-107.
2009: Saori Koh; Tappei Takada; Ikuya Kukuu; Hiroshi Suzuki
FIC1-mediated stimulation of FXR activity is decreased with PFIC1 mutations in HepG2 cells.
Journal of gastroenterology 2009;44(6):592-600.
2008: Kazuhiro Kobayashi; Kousei Ito; Tappei Takada; Yuichi Sugiyama; Hiroshi Suzuki
Functional analysis of nonsynonymous single nucleotide polymorphism type ATP-binding cassette transmembrane transporter subfamily C member 3.
Pharmacogenetics and genomics 2008;18(9):823-33.
2008: Naoko Yoshida; Tappei Takada; Yoshikazu Yamamura; Isao Adachi; Hiroshi Suzuki; Junichi Kawakami
Inhibitory effects of terpenoids on multidrug resistance-associated protein 2- and breast cancer resistance protein-mediated transport.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(7):1206-11.
2008: Kazuya Narushima; Tappei Takada; Yoshihide Yamanashi; Hiroshi Suzuki
Niemann-pick C1-like 1 mediates alpha-tocopherol transport.
Molecular pharmacology 2008;74(1):42-9.
2008: Yuki Iwayanagi; Tappei Takada; Hiroshi Suzuki
HNF4alpha is a crucial modulator of the cholesterol-dependent regulation of NPC1L1.
Pharmaceutical research 2008;25(5):1134-41.
2007: Takehito Yamamoto; Kousei Ito; Masashi Honma; Tappei Takada; Hiroshi Suzuki
Cholesterol-lowering effect of ezetimibe in uridine diphosphate glucuronosyltransferase 1A-deficient (Gunn) rats.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(9):1455-8.
2007: Masae Okuwaki; Tappei Takada; Yuki Iwayanagi; Saori Koh; Yoshiaki Kariya; Hiroshi Fujii; Hiroshi Suzuki
LXR alpha transactivates mouse organic solute transporter alpha and beta via IR-1 elements shared with FXR.
Pharmaceutical research 2007;24(2):390-8.
2007: Yoshihide Yamanashi; Tappei Takada; Hiroshi Suzuki
Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells.
The Journal of pharmacology and experimental therapeutics 2007;320(2):559-64.
2006: Tsukasa Okiyoneda; Akiko Niibori; Kazutsune Harada; Taijun Kohno; Yasuaki Hashimoto; Hiroyuki Kusuhara; Tappei Takada; Tsuyoshi Shuto; Mary Ann Suico; Yuichi Sugiyama; Hirofumi Kai
Bafilomycin A1-sensitive pathway is required for the maturation of cystic fibrosis transmembrane conductance regulator.
Biochimica et biophysica acta 2006;1763(10):1017-23.
2006: Tsukasa Okiyoneda; Taijun Kono; Akiko Niibori; Kazutsune Harada; Hiroyuki Kusuhara; Tappei Takada; Tsuyoshi Shuto; Mary Ann Suico; Yuichi Sugiyama; Hirofumi Kai
Calreticulin facilitates the cell surface expression of ABCG5/G8.
Biochemical and biophysical research communications 2006;347(1):67-75.
2005: Hisamitsu Hayashi; Tappei Takada; Hiroshi Suzuki; Reiko Onuki; Alan F Hofmann; Yuichi Sugiyama
Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep.
Biochimica et biophysica acta 2005;1738(1-3):54-62.
2005: Tappei Takada; Hiroshi Suzuki; Yukiko Gotoh; Yuichi Sugiyama
Regulation of the cell surface expression of human BCRP/ABCG2 by the phosphorylation state of Akt in polarized cells.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(7):905-9.
2005: Hisamitsu Hayashi; Tappei Takada; Hiroshi Suzuki; Hidetaka Akita; Yuichi Sugiyama
Two common PFIC2 mutations are associated with the impaired membrane trafficking of BSEP/ABCB11.
Hepatology (Baltimore, Md.) 2005;41(4):916-24.
2005: Tappei Takada; Hiroshi Suzuki; Yuichi Sugiyama
Characterization of polarized expression of point- or deletion-mutated human BCRP/ABCG2 in LLC-PK1 cells.
Pharmaceutical research 2005;22(3):458-64.
2004: Tappei Takada; H Markus Weiss; Olivier Kretz; Gerhard Gross; Yuichi Sugiyama
Hepatic transport of PKI166, an epidermal growth factor receptor kinase inhibitor of the pyrrolo-pyrimidine class, and its main metabolite, ACU154.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(11):1272-8.
2004: Tappei Takada; Hiroshi Suzuki
[Transporters for bile lipids].
Seikagaku. The Journal of Japanese Biochemical Society 2004;76(6):546-52.
2000: Tappei Takada; Hiroshi Suzuki; Yuichi Sugiyama
Characterization of 5'-flanking region of human MRP3.
Biochemical and biophysical research communications 2000;270(3):728-32.