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Christophe Bonny

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Saida Abdelli; Christophe Bonny
JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling.
Corinne Benakis; Christophe Bonny; Lorenz Hirt
JNK inhibition and inflammation after cerebral ischemia.
Anne-Caroline Bessero; Florence Chiodini; Elisabeth Rungger-Brändle; Christophe Bonny; Peter G H Clarke
Role of the c-Jun N-terminal kinase pathway in retinal excitotoxicity, and neuroprotection by its inhibition.

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All Publications

2012: Saida Abdelli; Christophe Bonny
JNK3 maintains expression of the insulin receptor substrate 2 (IRS2) in insulin-secreting cells: functional consequences for insulin signaling.
PloS one 2012;7(5):e35997.
2010: Corinne Benakis; Christophe Bonny; Lorenz Hirt
JNK inhibition and inflammation after cerebral ischemia.
Brain, behavior, and immunity 2010;24(5):800-11.
2010: Anne-Caroline Bessero; Florence Chiodini; Elisabeth Rungger-Brändle; Christophe Bonny; Peter G H Clarke
Role of the c-Jun N-terminal kinase pathway in retinal excitotoxicity, and neuroprotection by its inhibition.
Journal of neurochemistry 2010;113(5):1307-18.
2009: Saida Abdelli; J Puyal; C Bielmann; V Buchillier; Amar Abderrahmani; P G H Clarke; Jacques Beckmann; Christophe Bonny
JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis.
Diabetologia 2009;52(9):1871-80.
2009: Mariaelena Repici; L Mare; A Colombo; Cristina Ploia; A Sclip; Christophe Bonny; Pascal Nicod; M Salmona; Borsello Tiziana
c-Jun N-terminal kinase binding domain-dependent phosphorylation of mitogen-activated protein kinase kinase 4 and mitogen-activated protein kinase kinase 7 and balancing cross-talk between c-Jun N-terminal kinase and extracellular signal-regulated kinase pathways in cortical neurons.
Neuroscience 2009;159(1):94-103.
2008: Alexandre Sarre; Stephany Gardier; Fabienne Maurer; Christophe Bonny; Eric Raddatz
Modulation of the c-Jun N-terminal kinase activity in the embryonic heart in response to anoxia-reoxygenation: involvement of the Ca2+ and mitoKATP channels.
Molecular and cellular biochemistry 2008;313(1-2):133-8.
2008: Karine Wiegler; Christophe Bonny; Didier Coquoz; Lorenz Hirt
The JNK inhibitor XG-102 protects from ischemic damage with delayed intravenous administration also in the presence of recombinant tissue plasminogen activator.
Cerebrovascular diseases (Basel, Switzerland) 2008;26(4):360-6.
2007: Mariaelena Repici; C Centeno; Simone Tomasi; Gianluigi Forloni; Christophe Bonny; Alessandro Vercelli; Borsello Tiziana
Time-course of c-Jun N-terminal kinase activation after cerebral ischemia and effect of D-JNKI1 on c-Jun and caspase-3 activation.
Neuroscience 2007;150(1):40-9.
2007: Alessandra K Cardozo; Valérie Buchillier; Marc Mathieu; Jianhua Chen; Fernanda Ortis; Laurence Ladrière; Nathalie Allaman-Pillet; Olivier Poirot; Stephan Kellenberger; Jacques Beckmann; Decio L Eizirik; Christophe Bonny; Fabienne Maurer
Cell-permeable peptides induce dose- and length-dependent cytotoxic effects.
Biochimica et biophysica acta 2007;1768(9):2222-34.
2007: Saida Abdelli; Amar Abderrahmani; Bernhard J Hering; Jacques Beckmann; Christophe Bonny
The c-Jun N-terminal kinase JNK participates in cytokine- and isolation stress-induced rat pancreatic islet apoptosis.
Diabetologia 2007;50(8):1660-9.
2007: Giuseppina Milano; Sandrine Morel; Christophe Bonny; Michele Samaja; Ludwig K von Segesser; Pascal Nicod; Giuseppe Vassalli
A peptide inhibitor of c-Jun NH2-terminal kinase reduces myocardial ischemia-reperfusion injury and infarct size in vivo.
American journal of physiology. Heart and circulatory physiology 2007;292(4):H1828-35.
2007: Adrien A Eshraghi; Jing Wang; Eelam Adil; Jiao He; Azel Zine; Michael Bublik; Christophe Bonny; Jean-Luc Puel; Thomas J Balkany; Thomas R Van De Water
Blocking c-Jun-N-terminal kinase signaling can prevent hearing loss induced by both electrode insertion trauma and neomycin ototoxicity.
Hearing research 2007;226(1-2):168-77.
2007: Jing Wang; Jérôme Ruel; Sabine Ladrech; Christophe Bonny; Thomas R Van De Water; Jean-Luc Puel
Inhibition of the c-Jun N-terminal kinase-mediated mitochondrial cell death pathway restores auditory function in sound-exposed animals.
Molecular pharmacology 2007;71(3):654-66.
2007: C Centeno; Mariaelena Repici; Jean-Yves Chatton; Beat M Riederer; Christophe Bonny; Pascal Nicod; M Price; Peter G H Clarke; S Papa; G Franzoso; Borsello Tiziana
Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons.
Cell death and differentiation 2007;14(2):240-53.
2006: Sylvie Guenat; Nathalie Rouleau; Christelle Bielmann; Julie Bedard; Fabienne Maurer; Nathalie Allaman-Pillet; Pascal Nicod; Martina Bielefeld-Sévigny; Jacques Beckmann; Christophe Bonny; Roger Bossé; Raphael Roduit
Homogeneous and nonradioactive high-throughput screening platform for the characterization of kinase inhibitors in cell lysates.
Journal of biomolecular screening 2006;11(8):1015-26.
2006: Sandrine Morel; Giuseppina Milano; Kathi Mujynya Ludunge; Antonio F Corno; Michele Samaja; Sylvain Fleury; Christophe Bonny; Lukas Kappenberger; Ludwig K von Segesser; Giuseppe Vassalli
Brief reoxygenation episodes during chronic hypoxia enhance posthypoxic recovery of LV function: role of mitogen-activated protein kinase signaling pathways.
Basic research in cardiology 2006;101(4):336-45.
2006: Adrien A Eshraghi; Jiao He; Cai Hong Mou; Marek Polak; Azel Zine; Christophe Bonny; Thomas J Balkany; Thomas R Van De Water
D-JNKI-1 treatment prevents the progression of hearing loss in a model of cochlear implantation trauma.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology 2006;27(4):504-11.
2006: Zhi-Ye Zhuang; Yeong-Ray Wen; De-Ren Zhang; Borsello Tiziana; Christophe Bonny; Gary R Strichartz; Isabelle Decosterd; Ru-Rong Ji
A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2006;26(13):3551-60.
2006: Ole Kristensen; Sylvie Guenat; Imran Dar; Nathalie Allaman-Pillet; Amar Abderrahmani; Mourad Ferdaoussi; Raphael Roduit; Fabienne Maurer; Jacques Beckmann; Jette S Kastrup; Michael Gajhede; Christophe Bonny
A unique set of SH3-SH3 interactions controls IB1 homodimerization.
The EMBO journal 2006;25(4):785-97.
2005: Daniel F Schorderet; Violaine d'Allèves Manzi; Kriss Canola; Christophe Bonny; Yvan Arsenijevic; Francis L Munier; Fabienne Maurer
D-TAT transporter as an ocular peptide delivery system.
Clinical & experimental ophthalmology 2005;33(6):628-35.
2005: L Larsen; Joachim Størling; Martine I Darville; Decio L Eizirik; Christophe Bonny; Nils Billestrup; Thomas Mandrup-Poulsen
Extracellular signal-regulated kinase is essential for interleukin-1-induced and nuclear factor kappaB-mediated gene expression in insulin-producing INS-1E cells.
Diabetologia 2005;48(12):2582-90.
2005: Joachim Størling; Nathalie Allaman-Pillet; Allan E Karlsen; Nils Billestrup; Christophe Bonny; Thomas Mandrup-Poulsen
Antitumorigenic effect of proteasome inhibitors on insulinoma cells.
Endocrinology 2005;146(4):1718-26.
2005: Christophe Bonny; Borsello Tiziana; Azel Zine
Targeting the JNK pathway as a therapeutic protective strategy for nervous system diseases.
Reviews in the neurosciences 2005;16(1):57-67.
2004: David Michod; Jiang-Yan Yang; Jianhua Chen; Christophe Bonny; Christian Widmann
A RasGAP-derived cell permeable peptide potently enhances genotoxin-induced cytotoxicity in tumor cells.
Oncogene 2004;23(55):8971-8.
2004: Saida Abdelli; Jeffrey D Ansite; Raphael Roduit; Borsello Tiziana; Ippei Matsumoto; Toshiya Sawada; Nathalie Allaman-Pillet; Hugues Henry; Jacques Beckmann; Bernhard J Hering; Christophe Bonny
Intracellular stress signaling pathways activated during human islet preparation and following acute cytokine exposure.
Diabetes 2004;53(11):2815-23.
2004: Nathalie Allaman-Pillet; Raphael Roduit; Anne Oberson; Saida Abdelli; J Ruiz; Jacques Beckmann; Daniel F Schorderet; Christophe Bonny
Circadian regulation of islet genes involved in insulin production and secretion.
Molecular and cellular endocrinology 2004;226(1-2):59-66.
2004: Angela Tenzer; Barbara Hofstetter; Christelle Sauser; Stephan Bodis; August P Schubiger; Christophe Bonny; Martin Pruschy
Profiling treatment-specific post-translational modifications in a complex proteome with subtractive substrate phage display.
Proteomics 2004;4(9):2796-804.
2004: Lorenz Hirt; Jérôme Badaut; Jonathan Thevenet; Cristina Granziera; luca regli; Fabienne Maurer; Christophe Bonny; daryoush heydari
D-JNKI1, a cell-penetrating c-Jun-N-terminal kinase inhibitor, protects against cell death in severe cerebral ischemia.
Stroke; a journal of cerebral circulation 2004;35(7):1738-43.
2004: Borsello Tiziana; Christophe Bonny
Use of cell-permeable peptides to prevent neuronal degeneration.
Trends in molecular medicine 2004;10(5):239-44.
2003: Nathalie Allaman-Pillet; Joachim Størling; Anne Oberson; Raphael Roduit; Stéphanie Negri; Christelle Sauser; Pascal Nicod; Jacques Beckmann; Daniel F Schorderet; Thomas Mandrup-Poulsen; Christophe Bonny
Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1.
The Journal of biological chemistry 2003;278(49):48720-6.
2003: Imran Dar; Christophe Bonny; Jan Torleif Pedersen; Michael Gajhede; Ole Kristensen
Crystallization and preliminary crystallographic characterization of an SH3 domain from the IB1 scaffold protein.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 12):2300-2.
2003: Jing Wang; Thomas R Van De Water; Christophe Bonny; Francois de Ribaupierre; Jean-Luc Puel; Azel Zine
A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(24):8596-607.
2003: Borsello Tiziana; Peter G H Clarke; Lorenz Hirt; Alessandro Vercelli; Mariaelena Repici; Daniel F Schorderet; daryoush heydari; Christophe Bonny
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia.
Nature medicine 2003;9(9):1180-6.
2003: Sabine Morand; Valérie Buchillier; Fabienne Maurer; Christophe Bonny; Yvan Arsenijevic; Francis L Munier; Daniel F Schorderet
Induction of apoptosis in human corneal and HeLa cells by mutated BIGH3.
Investigative ophthalmology & visual science 2003;44(7):2973-9.
2002: Carole T Monney; Valérie Kaltenrieder; Pascal Cousin; Christophe Bonny; Daniel F Schorderet
Large Family With Maturity-Onset Diabetes of the Young and a Novel V121I Mutation in HNF4A.
Human mutation 2002;20(3):230-1.
2001: Amar Abderrahmani; M Steinmann; Valérie Plaisance; Guy Niederhauser; Jacques-Antoine Haefliger; Vincent Mooser; Christophe Bonny; Pascal Nicod; Gérard Waeber
The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1).
Molecular and cellular biology 2001;21(21):7256-67.
2001: Christophe Bonny; Anne Oberson; Stéphanie Negri; Christelle Sauser; Daniel F Schorderet
Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death.
Diabetes 2001;50(1):77-82.
2000: A Ammendrup; A Maillard; K Nielsen; N Aabenhus Andersen; P Serup; O Dragsbaek Madsen; Thomas Mandrup-Poulsen; Christophe Bonny
The c-Jun amino-terminal kinase pathway is preferentially activated by interleukin-1 and controls apoptosis in differentiating pancreatic beta-cells.
Diabetes 2000;49(9):1468-76.
2000: Christophe Bonny; Anne Oberson; M Steinmann; Daniel F Schorderet; Pascal Nicod; Gérard Waeber
IB1 reduces cytokine-induced apoptosis of insulin-secreting cells.
The Journal of biological chemistry 2000;275(22):16466-72.
2000: Nathalie Allaman-Pillet; V Kaltenrieder; S Mathieu; Christophe Bonny; Daniel F Schorderet
[Inactivation of the X-chromosome in female mammals].
Revue médicale de la Suisse romande 2000;120(5):431-4.
2000: Christophe Bonny; Anne Oberson; Stéphanie Negri; Christelle Sauser; Daniel F Schorderet
[Diabetes and genetics: significance of intracellular signaling pathways].
Revue médicale de la Suisse romande 2000;120(5):409-13.
2000: Gérard Waeber; Jérôme Delplanque; Christophe Bonny; Vincent Mooser; M Steinmann; Christian Widmann; A Maillard; Judith Miklossy; Christian Dina; El Habib Hani; Nathalie Vionnet; Pascal Nicod; Philippe Boutin; philippe froguel
The gene MAPK8IP1, encoding islet-brain-1, is a candidate for type 2 diabetes.
Nature genetics 2000;24(3):291-5.
2000: J B Pellet; Jacques-Antoine Haefliger; Julie K Staple; Christian Widmann; Egbert Welker; Harald Hirling; Christophe Bonny; P Nicod; Stefan Catsicas; Gérard Waeber; Beat M Riederer
Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain.
The European journal of neuroscience 2000;12(2):621-32.
2000: Nathalie Allaman-Pillet; A Djemaï; Christophe Bonny; Daniel F Schorderet
The 5' repeat elements of the mouse Xist gene inhibit the transcription of X-linked genes.
Gene expression 2000;9(3):93-101.
1999: Gérard Waeber; Thierry Calandra; Christophe Bonny; R Bucala
A role for the endocrine and pro-inflammatory mediator MIF in the control of insulin secretion during stress.
Diabetes/metabolism research and reviews 1999;15(1):47-54.
1998: Christophe Bonny; Pascal Nicod; Gérard Waeber
IB1, a JIP-1-related nuclear protein present in insulin-secreting cells.
The Journal of biological chemistry 1998;273(4):1843-6.
1998: Nathalie Allaman-Pillet; A Djemaï; Christophe Bonny; Daniel F Schorderet
Methylation status of CpG sites and methyl-CpG binding proteins are involved in the promoter regulation of the mouse Xist gene.
Gene expression 1998;7(2):61-73.
1997: Christophe Bonny; Raphael Roduit; Sandrine Gremlich; Pascal Nicod; Bernard Thorens; Gérard Waeber
The loss of GLUT2 expression in the pancreatic beta-cells of diabetic db/db mice is associated with an impaired DNA-binding activity of islet-specific trans-acting factors.
Molecular and cellular endocrinology 1997;135(1):59-65.
1997: Sandrine Gremlich; Christophe Bonny; Gérard Waeber; Bernard Thorens
Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels.
The Journal of biological chemistry 1997;272(48):30261-9.
1997: Gérard Waeber; Thierry Calandra; Raphael Roduit; Jacques-Antoine Haefliger; Christophe Bonny; Norman W Thompson; Bernard Thorens; E Temler; A Meinhardt; Michael Bacher; Christine N Metz; Pascal Nicod; R Bucala
Insulin secretion is regulated by the glucose-dependent production of islet beta cell macrophage migration inhibitory factor.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(9):4782-7.
1996: Gérard Waeber; Norman W Thompson; Pascal Nicod; Christophe Bonny
Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor.
Molecular endocrinology (Baltimore, Md.) 1996;10(11):1327-34.
1995: N Pillet; Christophe Bonny; Daniel F Schorderet
Characterization of the promoter region of the mouse Xist gene.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(26):12515-9.
1995: Gérard Waeber; T Pedrazzini; O Bonny; Christophe Bonny; M Steinmann; Pascal Nicod; Jacques-Antoine Haefliger
A 338-bp proximal fragment of the glucose transporter type 2 (GLUT2) promoter drives reporter gene expression in the pancreatic islets of transgenic mice.
Molecular and cellular endocrinology 1995;114(1-2):205-15.
1995: Christophe Bonny; Norman W Thompson; Pascal Nicod; Gérard Waeber
Pancreatic-specific expression of the glucose transporter type 2 gene: identification of cis-elements and islet-specific trans-acting factors.
Molecular endocrinology (Baltimore, Md.) 1995;9(10):1413-26.