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Junichi Takagi

Research Profile

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Publications

TOP 3
Bing-Hao Luo; Christopher V Carman; Junichi Takagi; Timothy A Springer
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.
JianFeng Chen; Junichi Takagi; Can Xie; Tsan Xiao; Bing-Hao Luo; Timothy A Springer
The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7.
Tsan Xiao; Junichi Takagi; Barry S Coller; Jia-huai Wang; Timothy A Springer
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics.

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All Publications

2005: Bing-Hao Luo; Christopher V Carman; Junichi Takagi; Timothy A Springer
Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(10):3679-84.
2004: JianFeng Chen; Junichi Takagi; Can Xie; Tsan Xiao; Bing-Hao Luo; Timothy A Springer
The relative influence of metal ion binding sites in the I-like domain and the interface with the hybrid domain on rolling and firm adhesion by integrin alpha4beta7.
The Journal of biological chemistry 2004;279(53):55556-61.
2004: Tsan Xiao; Junichi Takagi; Barry S Coller; Jia-huai Wang; Timothy A Springer
Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics.
Nature 2004;432(7013):59-67.
2004: Bing-Hao Luo; Konstantin Strokovich; Thomas Walz; Timothy A Springer; Junichi Takagi
Allosteric beta1 integrin antibodies that stabilize the low affinity state by preventing the swing-out of the hybrid domain.
The Journal of biological chemistry 2004;279(26):27466-71.
2004: Bing-Hao Luo; Timothy A Springer; Junichi Takagi
A specific interface between integrin transmembrane helices and affinity for ligand.
PLoS biology 2004;2(6):e153.
2004: Bing-Hao Luo; Junichi Takagi; Timothy A Springer
Locking the beta3 integrin I-like domain into high and low affinity conformations with disulfides.
The Journal of biological chemistry 2004;279(11):10215-21.
2004: WEI YANG; Motomu Shimaoka; Azucena Salas; Junichi Takagi; Timothy A Springer
Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(9):2906-11.
2003: Junichi Takagi; Konstantin Strokovich; Timothy A Springer; Thomas Walz
Structure of integrin alpha5beta1 in complex with fibronectin.
The EMBO journal 2003;22(18):4607-15.
2003: Bing-Hao Luo; Timothy A Springer; Junichi Takagi
High affinity ligand binding by integrins does not involve head separation.
The Journal of biological chemistry 2003;278(19):17185-9.
2003: Bing-Hao Luo; Timothy A Springer; Junichi Takagi
Stabilizing the open conformation of the integrin headpiece with a glycan wedge increases affinity for ligand.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(5):2403-8.
2003: Motomu Shimaoka; Tsan Xiao; Jin-Huan Liu; Yuting Yang; Yicheng Dong; Chang-Duk Jun; Alison McCormack; Rongguang Zhang; Andrzej Joachimiak; Junichi Takagi; Jia-huai Wang; Timothy A Springer
Structures of the alpha L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation.
Cell 2003;112(1):99-111.
2002: Motomu Shimaoka; Chafen Lu; Azucena Salas; Tsan Xiao; Junichi Takagi; Timothy A Springer
Stabilizing the integrin alpha M inserted domain in alternative conformations with a range of engineered disulfide bonds.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(26):16737-41.
2002: Hua Jing; Junichi Takagi; Jin-huan Liu; Sara Lindgren; Rong-guang Zhang; Andrzej Joachimiak; Jia-huai Wang; Timothy A Springer
Archaeal surface layer proteins contain beta propeller, PKD, and beta helix domains and are related to metazoan cell surface proteins.
Structure (London, England : 1993) 2002;10(10):1453-64.
2002: Junichi Takagi; Benjamin M Petre; Thomas Walz; Timothy A Springer
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling.
Cell 2002;110(5):599-11.
2002: Junichi Takagi; Timothy A Springer
Integrin activation and structural rearrangement.
Immunological reviews 2002;186():141-63.
2002: Junichi Takagi; Daniel P DeBottis; Harold P Erickson; Timothy A Springer
The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding.
Biochemistry 2002;41(13):4339-47.
2002: Natalia Beglova; Stephen C Blacklow; Junichi Takagi; Timothy A Springer
Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.
Nature structural biology 2002;9(4):282-7.
2002: Rahul Kohli; Junichi Takagi; Christopher T Walsh
The thioesterase domain from a nonribosomal peptide synthetase as a cyclization catalyst for integrin binding peptides.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(3):1247-52.
2002: Motomu Shimaoka; Junichi Takagi; Timothy A Springer
Conformational regulation of integrin structure and function.
Annual review of biophysics and biomolecular structure 2002;31():485-516.
2001: Junichi Takagi; Natalia Beglova; P Yalamanchili; Stephen C Blacklow; Timothy A Springer
Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(20):11175-80.
2001: Chang-Duk Jun; Motomu Shimaoka; Christopher V Carman; Junichi Takagi; Timothy A Springer
Dimerization and the effectiveness of ICAM-1 in mediating LFA-1-dependent adhesion.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(12):6830-5.
2001: Hyesung Jeon; W Meng; Junichi Takagi; Michael J Eck; Timothy A Springer; Stephen C Blacklow
Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.
Nature structural biology 2001;8(6):499-504.
2001: Motomu Shimaoka; Chafen Lu; Roger Palframan; Ulrich H von Andrian; A McCormack; Junichi Takagi; Timothy A Springer
Reversibly locking a protein fold in an active conformation with a disulfide bond: integrin alphaL I domains with high affinity and antagonist activity in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(11):6009-14.
2001: Chafen Lu; Junichi Takagi; Timothy A Springer
Association of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive state.
The Journal of biological chemistry 2001;276(18):14642-8.
2001: Junichi Takagi; Harold P Erickson; Timothy A Springer
C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1.
Nature structural biology 2001;8(5):412-6.
2001: Chafen Lu; M Ferzly; Junichi Takagi; Timothy A Springer
Epitope mapping of antibodies to the C-terminal region of the integrin beta 2 subunit reveals regions that become exposed upon receptor activation.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5629-37.
2001: Chafen Lu; Motomu Shimaoka; Q Zang; Junichi Takagi; Timothy A Springer
Locking in alternate conformations of the integrin alphaLbeta2 I domain with disulfide bonds reveals functional relationships among integrin domains.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2393-8.
2001: Chafen Lu; Motomu Shimaoka; M Ferzly; C Oxvig; Junichi Takagi; Timothy A Springer
An isolated, surface-expressed I domain of the integrin alphaLbeta2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond.
Proceedings of the National Academy of Sciences of the United States of America 2001;98(5):2387-92.
2000: Motomu Shimaoka; Julia M Shifman; H Jing; Junichi Takagi; Stephen L Mayo; Timothy A Springer
Computational design of an integrin I domain stabilized in the open high affinity conformation.
Nature structural biology 2000;7(8):674-8.
2000: Q Zang; Chafen Lu; Chao Huang; Junichi Takagi; Timothy A Springer
The top of the inserted-like domain of the integrin lymphocyte function-associated antigen-1 beta subunit contacts the alpha subunit beta -propeller domain near beta-sheet 3.
The Journal of biological chemistry 2000;275(29):22202-12.
2000: Chao Huang; Q Zang; Junichi Takagi; Timothy A Springer
Structural and functional studies with antibodies to the integrin beta 2 subunit. A model for the I-like domain.
The Journal of biological chemistry 2000;275(28):21514-24.