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Kenzo Takagi

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Tatsuya Hirayama; Tsutomu Kawabe; Miyoko Matsushima; Yuko Nishimura; Yuko Kobe; Yui Ota; Kenji Baba; Kenzo Takagi
Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues.
Miyoko Matsushima; Kenzo Takagi; Miyuki Ogawa; Etsuko Hirose; Yui Ota; Fumie Abe; Kenji Baba; Takaaki Hasegawa; Yoshinori Hasegawa; Tsutomu Kawabe
Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells.
Masataka Shibasaki; Katsunori Hashimoto; Masakazu Okamoto; Yuta Hayashi; Kazuyoshi Imaizumi; Naozumi Hashimoto; Nobuaki Ozaki; Toyoharu Yokoi; Kenzo Takagi; Yoshinori Hasegawa; Kaoru Shimokata; Tsutomu Kawabe
Up-regulation of surfactant protein production in a mouse model of secondary pulmonary alveolar proteinosis.

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All Publications

2010: Tatsuya Hirayama; Tsutomu Kawabe; Miyoko Matsushima; Yuko Nishimura; Yuko Kobe; Yui Ota; Kenji Baba; Kenzo Takagi
Ghrelin and obestatin promote the allergic action in rat peritoneal mast cells as basic secretagogues.
Peptides 2010;31(11):2109-13.
2009: Miyoko Matsushima; Kenzo Takagi; Miyuki Ogawa; Etsuko Hirose; Yui Ota; Fumie Abe; Kenji Baba; Takaaki Hasegawa; Yoshinori Hasegawa; Tsutomu Kawabe
Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells.
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2009;58(10):705-15.
2009: Masataka Shibasaki; Katsunori Hashimoto; Masakazu Okamoto; Yuta Hayashi; Kazuyoshi Imaizumi; Naozumi Hashimoto; Nobuaki Ozaki; Toyoharu Yokoi; Kenzo Takagi; Yoshinori Hasegawa; Kaoru Shimokata; Tsutomu Kawabe
Up-regulation of surfactant protein production in a mouse model of secondary pulmonary alveolar proteinosis.
American journal of respiratory cell and molecular biology 2009;40(5):536-42.
2009: Etsuko Hirose; Miyoko Matsushima; Kenzo Takagi; Yui Ota; Keiko Ishigami; Tatsuya Hirayama; Yuta Hayashi; Toshinobu Nakamura; Naozumi Hashimoto; Kazuyoshi Imaizumi; Kenji Baba; Yoshinori Hasegawa; Tsutomu Kawabe
Involvement of heme oxygenase-1 in kaempferol-induced anti-allergic actions in RBL-2H3 cells.
Inflammation 2009;32(2):99-108.
2008: Jun Ueyama; Masayuki Nadai; Ying Lan Zhao; Hiroaki Kanazawa; Kenzo Takagi; Takaaki Kondo; Kenji Takagi; Shinya Wakusawa; Fumie Abe; Hiroko Saito; Ken-Ichi Miyamoto; Takaaki Hasegawa
Effect of thalidomide on endotoxin-induced decreases in activity and expression of hepatic cytochrome P450 3A2.
Biological & pharmaceutical bulletin 2008;31(8):1596-600.
2008: Atsushi Sumida; Yoshinori Hasegawa; Masakazu Okamoto; Naozumi Hashimoto; Kazuyoshi Imaizumi; Hiroshi Yatsuya; Toyoharu Yokoi; Kenzo Takagi; Kaoru Shimokata; Tsutomu Kawabe
TH1/TH2 immune response in lung fibroblasts in interstitial lung disease.
Archives of medical research 2008;39(5):503-10.
2007: Hironao Nakayama; Kiyoyuki Kitaichi; Yukiko Ito; Katsunori Hashimoto; Kenji Takagi; Toyoharu Yokoi; Kenzo Takagi; Norio Ozaki; Tuneyuki Yamamoto; Takaaki Hasegawa
The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats.
Brain research 2007;1184():260-9.
2007: Dong Wang; Michihiro Kamijima; Ryota Imai; Takayoshi Suzuki; Yohei Kameda; Kazumi Asai; Ai Okamura; Hisao Naito; Jun Ueyama; Isao Saito; Tamie Nakajima; Masahiro Goto; Eiji Shibata; Takaaki Kondo; Kenji Takagi; Kenzo Takagi; Shinya Wakusawa
Biological monitoring of pyrethroid exposure of pest control workers in Japan.
Journal of occupational health 2007;49(6):509-14.
2007: Masakazu Okamoto; Kazuyoshi Imaizumi; Yoshinori Hasegawa; Naozumi Hashimoto; Atsushi Sumida; Masataka Shibazaki; Kenzo Takagi; Kaoru Shimokata; Tsutomu Kawabe
Macrophage-derived chemokine in malignant and tuberculous pleural effusions.
Respirology (Carlton, Vic.) 2007;12(4):581-4.
2007: Jun Ueyama; Dong Wang; Takaaki Kondo; Isao Saito; Kenji Takagi; Kenzo Takagi; Michihiro Kamijima; Tamie Nakajima; Ken-Ichi Miyamoto; Shinya Wakusawa; Takaaki Hasegawa
Toxicity of diazinon and its metabolites increases in diabetic rats.
Toxicology letters 2007;170(3):229-37.
2007: Yohei Fujimoto; Kiyoyuki Kitaichi; Hironao Nakayama; Yukiko Ito; Kenji Takagi; Kenzo Takagi; Takaaki Hasegawa
The pharmacokinetic properties of methamphetamine in rats with previous repeated exposure to methamphetamine: the differences between Long-Evans and Wistar rats.
Experimental animals / Japanese Association for Laboratory Animal Science 2007;56(2):119-29.
2006: Satoshi Suzuki; Hisao Hayashi; Kenzo Takagi; Takaaki Kondo; Kenji Takagi; Jun Ueyama; Shinya Wakusawa
Protein kinase Cbeta isoform down-regulates the expression of MDR3 P-glycoprotein in human Chang liver cells.
Biochimica et biophysica acta 2006;1760(10):1552-7.
2006: Tatsuya Suzuki; Ying Lan Zhao; Masayuki Nadai; Kazumasa Naruhashi; Akemi Shimizu; Kenji Takagi; Kenzo Takagi; Takaaki Hasegawa
Gender-related differences in expression and function of hepatic P-glycoprotein and multidrug resistance-associated protein (Mrp2) in rats.
Life sciences 2006;79(5):455-61.
2006: Hiroyuki Nosaka; Masayuki Nadai; Miki Kato; Kazumasa Yasui; Hideo Yoshizumi; Mika Miyoshi; Ying Lan Zhao; Kenji Baba; Kenzo Takagi; Takaaki Hasegawa
Effect of a newly developed ketolide antibiotic, telithromycin, on metabolism of theophylline and expression of cytochrome P450 in rats.
Life sciences 2006;79(1):50-6.
2006: Kensuke Kataoka; Ryujiro Suzuki; Hiroyuki Taniguchi; Yasunobu Noda; Joe Shindoh; Syuichi Matsumoto; Yoshiaki Watanabe; Kousuke Honda; Kiyoshi Suzuki; Kenji Baba; Kazuyoshi Imaizumi; Hiroaki Kume; Yoshinori Hasegawa; Kenzo Takagi
Phase I/II trial of docetaxel and carboplatin as a first-line therapy in patients with stage IV non-small-cell lung cancer.
Lung 2006;184(3):133-9.
2006: Hironao Nakayama; Kiyoyuki Kitaichi; Hiroaki Kanazawa; Mai Ando; Yohei Fujimoto; Kenji Takagi; Kenzo Takagi; Takaaki Hasegawa
Effect of Shiga-like toxin II from Escherichia coli O157:H7 on intestinal clearance of norfloxacin in rats.
Life sciences 2006;78(17):1967-74.
2006: Jun Ueyama; Isao Saito; Michihiro Kamijima; Tamie Nakajima; Masahiro Gotoh; Takayoshi Suzuki; Eiji Shibata; Takaaki Kondo; Kenji Takagi; Ken-ichi Miyamoto; Junki Takamatsu; Takaaki Hasegawa; Kenzo Takagi
Simultaneous determination of urinary dialkylphosphate metabolites of organophosphorus pesticides using gas chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2006;832(1):58-66.
2006: Shoji Yamaguchi; Ying Lan Zhao; Masayuki Nadai; Hideo Yoshizumi; Xiaobo Cen; Shoko Torita; Kenzo Takagi; Kenji Takagi; Takaaki Hasegawa
Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport.
Antimicrobial agents and chemotherapy 2006;50(1):80-7.
2005: Kiyoyuki Kitaichi; Masaya Fukuda; Hironao Nakayama; Nagisa Aoyama; Yukiko Ito; Yohei Fujimoto; Kenzo Takagi; Kenji Takagi; Takaaki Hasegawa
Behavioral changes following antisense oligonucleotide-induced reduction of organic cation transporter-3 in mice.
Neuroscience letters 2005;382(1-2):195-200.
2005: Masaya Fukuda; Kiyoyuki Kitaichi; Fumie Abe; Yohei Fujimoto; Kenji Takagi; Kenzo Takagi; Tsuneo Morishima; Takaaki Hasegawa
Altered brain penetration of diclofenac and mefenamic acid, but not acetaminophen, in Shiga-like toxin II-treated mice.
Journal of pharmacological sciences 2005;97(4):525-32.
2005: Jun Ueyama; Masayuki Nadai; Hiroaki Kanazawa; Mitsunori Iwase; Hironao Nakayama; Katsunori Hashimoto; Toyoharu Yokoi; Kenji Baba; Kenzo Takagi; Kenji Takagi; Takaaki Hasegawa
Endotoxin from various gram-negative bacteria has differential effects on function of hepatic cytochrome P450 and drug transporters.
European journal of pharmacology 2005;510(1-2):127-34.
2005: Mika Miyoshi; Masayuki Nadai; Atsumi Nitta; Jun Ueyama; Akemi Shimizu; Kenji Takagi; Toshitaka Nabeshima; Kenzo Takagi; Kuniaki Saito; Takaaki Hasegawa
Role of tumor necrosis factor-alpha in down-regulation of hepatic cytochrome P450 and P-glycoprotein by endotoxin.
European journal of pharmacology 2005;507(1-3):229-37.
2004: Akemi Shimizu; Mika Miyoshi; Masami Sugie; Jun Ueyama; Takuji Yamaguchi; Toshinobu Sasaki; Kenzo Takagi; Mingji Jin; Ken-Ichi Miyamoto; Akira Tsuji; Takaaki Hasegawa
Possible involvement of P-glycoprotein in renal excretion of pazufloxacin in rats.
European journal of pharmacology 2004;501(1-3):151-9.
2004: Kiyoyuki Kitaichi; Yukiko Ito; Masaya Fukuda; Nagisa Aoyama; Hironao Nakayama; Kenzo Takagi; Takaaki Hasegawa
The altered disposition of methamphetamine in the model of methamphetamine-induced neurotoxicity.
Annals of the New York Academy of Sciences 2004;1025():248-56.
2004: Jun Ueyama; Kiyoyuki Kitaichi; Masayuki Nadai; Mitsunori Iwase; Nao Tomyo; Hiroaki Kanazawa; Ryujiro Suzuki; Kenzo Takagi; Kenji Takagi; Takaaki Hasegawa
Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity and expression of CYP3A2 and CYP2C11.
European journal of pharmacology 2004;498(1-3):257-65.
2004: Kiyoyuki Kitaichi; Hironao Nakayama; Jun Ueyama; Masayuki Nadai; Kenji Baba; Kenji Takagi; Kenzo Takagi; Michio Ohta; Takaaki Hasegawa
Down-regulation of cytochrome P450 proteins and its activities by Shiga-like toxin II from Escherichia coli O157:H7.
Biochemical pharmacology 2004;67(8):1427-35.
2004: Masami Sugie; Emiko Asakura; Ying Lan Zhao; Shoko Torita; Masayuki Nadai; Kenji Baba; Kiyoyuki Kitaichi; Kenzo Takagi; Kenji Takagi; Takaaki Hasegawa
Possible involvement of the drug transporters P glycoprotein and multidrug resistance-associated protein Mrp2 in disposition of azithromycin.
Antimicrobial agents and chemotherapy 2004;48(3):809-14.
2004: Kenji Takagi; Yasuaki Tatsumi; Kiyoyuki Kitaichi; Mitsunori Iwase; Eiji Shibata; Makoto Nakao; Takatoshi Matsumoto; Kenzo Takagi; Takaaki Hasegawa
A sensitive colorimetric assay for polyamines in erythrocytes using oat seedling polyamine oxidase.
Clinica chimica acta; international journal of clinical chemistry 2004;340(1-2):219-27.
2004: Emiko Asakura; Hironao Nakayama; Masami Sugie; Ying Lan Zhao; Masayuki Nadai; Kiyoyuki Kitaichi; Akemi Shimizu; Mika Miyoshi; Kenji Takagi; Kenzo Takagi; Takaaki Hasegawa
Azithromycin reverses anticancer drug resistance and modifies hepatobiliary excretion of doxorubicin in rats.
European journal of pharmacology 2004;484(2-3):333-9.
2003: Jun Ueyama; Kiyoyuki Kitaichi; Mitsunori Iwase; Kenji Takagi; Kenzo Takagi; Takaaki Hasegawa
Application of ultrafiltration method to measurement of catecholamines in plasma of human and rodents by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2003;798(1):35-41.
2003: Yosuke Kato; Mitsunori Iwase; Hiroaki Kanazawa; Natsuki Kawata; Yukie Yoshimori; Katsunori Hashimoto; Toyoharu Yokoi; Akiko Noda; Kenzo Takagi; Yasuo Koike; Takao Nishizawa; Masahiko Nishimura; Mitsuhiro Yokota
Progressive development of pulmonary hypertension leading to right ventricular hypertrophy assessed by echocardiography in rats.
Experimental animals / Japanese Association for Laboratory Animal Science 2003;52(4):285-94.
2003: Kazuhiko Hidemura; Ying Lan Zhao; Katsuki Ito; Akimasa Nakao; Yasuaki Tatsumi; Hiroaki Kanazawa; Kenzo Takagi; Michio Ohta; Takaaki Hasegawa
Shiga-like toxin II impairs hepatobiliary transport of doxorubicin in rats by down-regulation of hepatic P glycoprotein and multidrug resistance-associated protein Mrp2.
Antimicrobial agents and chemotherapy 2003;47(5):1636-42.
2003: Miyoko Matsushima; Kiyoyuki Kitaichi; Yasuaki Tatsumi; Takaaki Hasegawa; Kenzo Takagi
The expression of mRNA for calcitonin receptor-like receptor/receptor-activity modifying proteins in rat peritoneal mast cells.
European journal of pharmacology 2003;464(2-3):111-4.
2003: Kiyoyuki Kitaichi; Yuki Morishita; Yuko Doi; Jun Ueyama; Miyoko Matsushima; Ying Lan Zhao; Kenzo Takagi; Takaaki Hasegawa
Increased plasma concentration and brain penetration of methamphetamine in behaviorally sensitized rats.
European journal of pharmacology 2003;464(1):39-48.
2002: Hiroaki Kume; Masashi Kondo; Yasushi Ito; Ryujiro Suzuki; Kenichi Yamaki; Kenzo Takagi
Effects of sustained-release tulobuterol on asthma control and beta-adrenoceptor function.
Clinical and experimental pharmacology & physiology 2002;29(12):1076-83.
2002: Ying Lan Zhao; Jun Du; Hiroaki Kanazawa; Xiaobo Cen; Kenzo Takagi; Kiyoyuki Kitaichi; Yasuaki Tatsumi; Kenji Takagi; Michio Ohta; Takaaki Hasegawa
Shiga-like toxin II modifies brain distribution of a P-glycoprotein substrate, doxorubicin, and P-glycoprotein expression in mice.
Brain research 2002;956(2):246-53.
2002: Yuko Ito; Akiko Tamakoshi; Kenji Wakai; Kenzo Takagi; Kenichi Yamaki; Yoshiyuki Ohno
Trends in asthma mortality in Japan.
The Journal of asthma : official journal of the Association for the Care of Asthma 2002;39(7):633-9.
2002: Ryujiro Suzuki; Tomoki Kimura; Kiyoyuki Kitaichi; Yasuaki Tatsumi; Miyoko Matsushima; Ying Lan Zhao; Eiji Shibata; Kenji Baba; Takaaki Hasegawa; Kenzo Takagi
Platelet factor 4 fragment induces histamine release from rat peritoneal mast cells.
Peptides 2002;23(10):1713-7.
2002: Yasushi Ito; Shinji Sato; Masami Son; Hiroaki Kume; Kenzo Takagi; Kenichi Yamaki
Bioelectric toxicity caused by chlorpromazine in human lung epithelial cells.
Toxicology and applied pharmacology 2002;183(3):198-206.
2002: Hiroshi Mizutani; Hiroaki Kume; Yasushi Ito; Kenzo Takagi; Kenichi Yamaki
Different effects of beta-adrenoceptor desensitization on inhibitory actions in guinea-pig trachealis.
Clinical and experimental pharmacology & physiology 2002;29(8):646-54.
2002: Ying Lan Zhao; Jun Du; Hiroaki Kanazawa; Ayako Sugawara; Kenji Takagi; Kiyoyuki Kitaichi; Yasuaki Tatsumi; Kenzo Takagi; Takaaki Hasegawa
Effect of endotoxin on doxorubicin transport across blood-brain barrier and P-glycoprotein function in mice.
European journal of pharmacology 2002;445(1-2):115-23.
2002: Ying Lan Zhao; Xiaobo Cen; Masafumi Ito; Keiko Yokoyama; Kenji Takagi; Kiyoyuki Kitaichi; Masayuki Nadai; Michio Ohta; Kenzo Takagi; Takaaki Hasegawa
Shiga-like toxin II derived from Escherichia coli O157:H7 modifies renal handling of levofloxacin in rats.
Antimicrobial agents and chemotherapy 2002;46(5):1522-8.
2002: Ying Lan Zhao; Shao Hui Cai; Li Wang; Kiyoyuki Kitaichi; Yasuaki Tatsumi; Masayuki Nadai; Hideo Yoshizumi; Kenji Takagi; Kenzo Takagi; Takaaki Hasegawa
Possible involvement of P-glycoprotein in the biliary excretion of grepafloxacin.
Clinical and experimental pharmacology & physiology 2002;29(3):167-72.
2002: Masayuki Takeuchi; Yasuaki Tatsumi; Kiyoyuki Kitaichi; Kenji Baba; Ryujiro Suzuki; Eiji Shibata; Kenji Takagi; Ken-ichi Miyamoto; Takaaki Hasegawa; Kenzo Takagi
Selective phosphodiesterase type 4 inhibitors reduce the prolonged survival of eosinophils stimulated by granulocyte-macrophage colony-stimulating factor.
Biological & pharmaceutical bulletin 2002;25(2):184-7.
2002: Yukio Sudo; Hiroaki Kume; Satoru Ito; Yasushi Ito; Kenichi Yamaki; Kenzo Takagi
Effects of direct and indirect activation of G protein of adenylyl cyclase on the subsequent response to beta-adrenergic receptor agonists in human trachealis.
Arzneimittel-Forschung 2002;52(11):803-12.
1998: T Katoh; T Andoh; K Mikawa; M Tanizawa; M Tanigawa; R Suzuki; Kenzo Takagi
Computed tomographic findings in non-specific interstitial pneumonia/fibrosis.
Respirology (Carlton, Vic.) 1998;3(2):69-75.