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Joseph Takahashi

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Seung-Hee Yoo; Ming Xu; Zheng Chen; Zhijian J Chen; Carla B Green; Hee-Kyung Hong; Seong Kwon Huh; Nobuya Koike; Izabela Kornblum; Vivek Kumar; Xinran Liu; Jennifer A Mohawk; Justin Nussbaum; Yongli Shan; Sandra M Siepka; Joseph S Takahashi
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.
Kazuhiro Shimomura; Martha Hotz Vitaterna; A Whiteley; Tim Wiltshire; Seung-Hee Yoo; Joseph Bass; Ethan D Buhr; Jason Chong; Deborah Fenner; John Hogenesch; Hee-Kyung Hong; Tae-Kyung Kim; Nobuya Koike; Vivek Kumar; Sharon S Low; Phillip L Lowrey; Chiaki Omura; Joseph R Owens; Mathew T Pletcher; Marc Richards; Joseph S Takahashi
Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice.
Nobuya Koike; Vivek Kumar; Choogon Lee; Hung-Chung Huang; Tae-Kyung Kim; Seung-Hee Yoo; Joseph S Takahashi
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals.

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All Publications

2013: Seung-Hee Yoo; Ming Xu; Zheng Chen; Zhijian J Chen; Carla B Green; Hee-Kyung Hong; Seong Kwon Huh; Nobuya Koike; Izabela Kornblum; Vivek Kumar; Xinran Liu; Jennifer A Mohawk; Justin Nussbaum; Yongli Shan; Sandra M Siepka; Joseph S Takahashi
Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.
Cell 2013;152(5):1091-105.
2013: Kazuhiro Shimomura; Martha Hotz Vitaterna; A Whiteley; Tim Wiltshire; Seung-Hee Yoo; Joseph Bass; Ethan D Buhr; Jason Chong; Deborah Fenner; John Hogenesch; Hee-Kyung Hong; Tae-Kyung Kim; Nobuya Koike; Vivek Kumar; Sharon S Low; Phillip L Lowrey; Chiaki Omura; Joseph R Owens; Mathew T Pletcher; Marc Richards; Joseph S Takahashi
Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice.
eLife 2013;2():e00426.
2012: Nobuya Koike; Vivek Kumar; Choogon Lee; Hung-Chung Huang; Tae-Kyung Kim; Seung-Hee Yoo; Joseph S Takahashi
Transcriptional architecture and chromatin landscape of the core circadian clock in mammals.
Science (New York, N.Y.) 2012;338(6105):349-54.
2012: Nian Huang; Carrie Partch; Yongli Shan; Yogarany Chelliah; Carla B Green; Clinton A Taylor; Seung-Hee Yoo; Hong Zhang; Joseph S Takahashi
Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
Science (New York, N.Y.) 2012;337(6091):189-94.
2012: Michael E Hughes; Alejandra A Indacochea; Samuel S Lee; Joseph S Takahashi; Jason L Chong; Michael Han; Hee-Kyung Hong; John B Hogenesch
Brain-specific rescue of Clock reveals system-driven transcriptional rhythms in peripheral tissue.
PLoS genetics 2012;8(7):e1002835.
2011: Deborah Fenner; Joseph Grimsby; Hee-Kyung Hong; Yumiko Kobayashi; Akira Kohsaka; Franz M Matschinsky; Stella Odili; Sandra M Siepka; Joseph S Takahashi; Martha Hotz Vitaterna; Bogumil Zelent; Pan Chen; Joseph Bass
Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.
The Journal of biological chemistry 2011;286(45):39560-72.
2011: Vivek Kumar; Heekyung Hong; Chryshanthi Joseph; Kyungin Kim; Lisa C Thomas; Joseph S Takahashi
Second-generation high-throughput forward genetic screen in mice to isolate subtle behavioral mutants.
Proceedings of the National Academy of Sciences of the United States of America 2011;108 Suppl 3():15557-64.
2011: Kafui Dzirasa; Sunil Kumar; Colleen A McClung; DeAnna L McGarity; Anirban Bhattacharya; David Dunson; Joseph S Takahashi; Miguel A L Nicolelis
Impaired limbic gamma oscillatory synchrony during anxiety-related behavior in a genetic mouse model of bipolar mania.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011;31(17):6449-56.
2010: Joseph Bass; Joseph S Takahashi
Circadian integration of metabolism and energetics.
Science (New York, N.Y.) 2010;330(6009):1349-54.
2010: Jessica L Andrews; Xiping Zhang; John J McCarthy; Erin L McDearmon; Troy A Hornberger; Brenda Russell; Kenneth S Campbell; sandrine Arbogast; Michael B Reid; John R Walker; John B Hogenesch; Joseph S Takahashi; Karyn A Esser
CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(44):19090-5.
2010: Ethan D Buhr; Seung-Hee Yoo; Joseph S Takahashi
Temperature as a universal resetting cue for mammalian circadian oscillators.
Science (New York, N.Y.) 2010;330(6002):379-85.
2010: Vivek Kumar; Joseph S Takahashi
PARP around the clock.
Cell 2010;142(6):841-3.
2010: Biliana Marcheva; Kathryn Moynihan Ramsey; Ethan D Buhr; Yumiko Kobayashi; Hong Su; Caroline Ko; Ganka Ivanova; Chiaki Omura; Shelley Mo; Martha H Vitaterna; James P Lopez; Louis H Philipson; Christopher A Bradfield; Seth D Crosby; Lellean JeBailey; Xiaozhong Wang; Joseph S Takahashi; Joseph Bass
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes.
Nature 2010;466(7306):627-31.
2010: Kazuhiro Shimomura; Phillip L Lowrey; Martha Hotz Vitaterna; Ethan D Buhr; Vivek Kumar; Peter Hanna; Chiaki Omura; Mariko Izumo; Sharon S Low; R Keith Barrett; Silvia I LaRue; Carla B Green; Joseph S Takahashi
Genetic suppression of the circadian Clock mutation by the melatonin biosynthesis pathway.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(18):8399-403.
2010: Caroline H Ko; Yujiro R Yamada; David K Welsh; Ethan D Buhr; Andrew C Liu; Eric Erquan Zhang; Martin R Ralph; Steve A Kay; Daniel B Forger; Joseph S Takahashi
Emergence of noise-induced oscillations in the central circadian pacemaker.
PLoS biology 2010;8(10):e1000513.
2010: David K Welsh; Joseph S Takahashi; Steve A Kay
Suprachiasmatic nucleus: cell autonomy and network properties.
Annual review of physiology 2010;72():551-77.
2009: Leah C Solberg Woods; Nasim Ahmadiyeh; Amber Baum; Kazuhiro Shimomura; Qian Li; Donald F Steiner; Fred W Turek; Joseph S Takahashi; Gary Churchill; Eva Redei
Identification of genetic loci involved in diabetes using a rat model of depression.
Mammalian genome : official journal of the International Mammalian Genome Society 2009;20(8):486-97.
2009: Kathryn Moynihan Ramsey; Jun Yoshino; Cynthia S Brace; Dana Abrassart; Yumiko Kobayashi; Biliana Marcheva; Hee-Kyung Hong; Jason L Chong; Ethan D Buhr; Choogon Lee; Joseph S Takahashi; Shin-Ichiro Imai; Joseph Bass
Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis.
Science (New York, N.Y.) 2009;324(5927):651-4.
2008: Joseph S Takahashi; Kazuhiro Shimomura; Vivek Kumar
Searching for genes underlying behavior: lessons from circadian rhythms.
Science (New York, N.Y.) 2008;322(5903):909-12.
2008: Joseph S Takahashi; Hee-Kyung Hong; Caroline Ko; Erin L McDearmon
The genetics of mammalian circadian order and disorder: implications for physiology and disease.
Nature reviews. Genetics 2008;9(10):764-75.
2008: Carla B Green; Joseph S Takahashi; Joseph Bass
The meter of metabolism.
Cell 2008;134(5):728-42.
2008: Chunlei Wu; David L Delano; Nico Mitro; Stephen V Su; Jeff Janes; Phillip McClurg; Serge Batalov; Genevieve L Welch; Jie Zhang; Anthony P Orth; John R Walker; Richard J Glynne; Michael P Cooke; Joseph S Takahashi; Kazuhiro Shimomura; Akira Kohsaka; Joseph Bass; Enrique Saez; Timothy Wiltshire; Andrew Su
Gene set enrichment in eQTL data identifies novel annotations and pathway regulators.
PLoS genetics 2008;4(5):e1000070.
2007: Lawrence H Pinto; Brandon M Invergo; Kazuhiro Shimomura; Joseph S Takahashi; John B Troy
Interpretation of the mouse electroretinogram.
Documenta ophthalmologica. Advances in ophthalmology 2007;115(3):127-36.
2007: John J McCarthy; Jessica L Andrews; Erin L McDearmon; Kenneth S Campbell; Brigham K Barber; Brooke H Miller; John R Walker; John B Hogenesch; Joseph S Takahashi; Karyn A Esser
Identification of the circadian transcriptome in adult mouse skeletal muscle.
Physiological genomics 2007;31(1):86-95.
2007: Sandra M Siepka; Seung-Hee Yoo; Junghea Park; Weimin Song; Vivek Kumar; Yinin Hu; Choogon Lee; Joseph S Takahashi
Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression.
Cell 2007;129(5):1011-23.
2007: Andrew C Liu; David K Welsh; Caroline Ko; Hien G Tran; Eric Erquan Zhang; Aaron A Priest; Ethan D Buhr; Oded Singer; Kirsten Meeker; Inder M Verma; Francis J Doyle; Joseph S Takahashi; Steve A Kay
Intercellular coupling confers robustness against mutations in the SCN circadian clock network.
Cell 2007;129(3):605-16.
2007: Phillip McClurg; Jeff Janes; Chunlei Wu; David L Delano; John R Walker; Serge Batalov; Joseph S Takahashi; Kazuhiro Shimomura; Akira Kohsaka; Joseph Bass; Timothy Wiltshire; Andrew Su
Genomewide association analysis in diverse inbred mice: power and population structure.
Genetics 2007;176(1):675-83.
2007: Kole Roybal; David Theobold; Ami Graham; Jennifer A DiNieri; Scott J Russo; Vaishnav Krishnan; Sumana Chakravarty; Joseph Peevey; Nathan Oehrlein; Shari Birnbaum; Martha Hotz Vitaterna; Paul Orsulak; Joseph S Takahashi; Eric J Nestler; William A Carlezon; Colleen A McClung
Mania-like behavior induced by disruption of CLOCK.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(15):6406-11.
2007: Brooke H Miller; Erin L McDearmon; Satchidananda Panda; Kevin R Hayes; Jie Zhang; Jessica L Andrews; Marina P Antoch; John R Walker; Karyn A Esser; John B Hogenesch; Joseph S Takahashi
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3342-7.
2007: Hee-Kyung Hong; Jason L Chong; Weimin Song; Eun-joo Song; Amira A Jyawook; Andrew C Schook; Caroline Ko; Joseph S Takahashi
Inducible and reversible Clock gene expression in brain using the tTA system for the study of circadian behavior.
PLoS genetics 2007;3(2):e33.
2007: Sandra M Siepka; Seung-Hee Yoo; J Park; Cheolju Lee; Joseph S Takahashi
Genetics and neurobiology of circadian clocks in mammals.
Cold Spring Harbor symposia on quantitative biology 2007;72():251-9.
2007: Lawrence H Pinto; Martha Hotz Vitaterna; Kazuhiro Shimomura; Sandra M Siepka; Victoria Balannik; Erin L McDearmon; Chiaki Omura; Stephen Lumayag; Brandon M Invergo; Brett Glawe; Donald R Cantrell; Samsoon Inayat; Marissa A Olvera; Kirstan A Vessey; Maureen A McCall; Dennis Maddox; Catherine W Morgans; Brandon Young; Mathew Pletcher; robert Mullins; John B Troy; Joseph S Takahashi
Generation, identification and functional characterization of the nob4 mutation of Grm6 in the mouse.
Visual neuroscience 2007;24(1):111-23.
2006: Erin L McDearmon; Kush N Patel; Caroline Ko; Jacqueline A Walisser; Andrew C Schook; Jason L Chong; Lisa D Wilsbacher; Eun-joo Song; Hee-Kyung Hong; Christopher A Bradfield; Joseph S Takahashi
Dissecting the functions of the mammalian clock protein BMAL1 by tissue-specific rescue in mice.
Science (New York, N.Y.) 2006;314(5803):1304-8.
2006: Brooke H Miller; Susan Losee Olson; Jon E Levine; Fred W Turek; Teresa H Horton; Joseph S Takahashi
Vasopressin regulation of the proestrous luteinizing hormone surge in wild-type and Clock mutant mice.
Biology of reproduction 2006;75(5):778-84.
2006: Caroline Ko; Joseph S Takahashi
Molecular components of the mammalian circadian clock.
Human molecular genetics 2006;15 Spec No 2():R271-7.
2006: Carla B Green; Joseph S Takahashi
Xenobiotic metabolism in the fourth dimension: PARtners in time.
Cell metabolism 2006;4(1):3-4.
2006: Martha Hotz Vitaterna; Caroline Ko; Anne-Marie Chang; Ethan D Buhr; Ethan M Fruechte; Andrew Schook; Marina P Antoch; Fred W Turek; Joseph S Takahashi
The mouse Clock mutation reduces circadian pacemaker amplitude and enhances efficacy of resetting stimuli and phase-response curve amplitude.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(24):9327-32.
2006: Martha Hotz Vitaterna; Lawrence H Pinto; Joseph S Takahashi
Large-scale mutagenesis and phenotypic screens for the nervous system and behavior in mice.
Trends in neurosciences 2006;29(4):233-40.
2006: Jennifer L Moran; Andrew D Bolton; Pamela V Tran; Alison Brown; Noelle D Dwyer; Danielle K Manning; Bryan Bjork; Cheng Li; Kate Montgomery; Sandra M Siepka; Martha Hotz Vitaterna; Joseph S Takahashi; Timothy Wiltshire; David J Kwiatkowski; Raju Kucherlapati; David Beier
Utilization of a whole genome SNP panel for efficient genetic mapping in the mouse.
Genome research 2006;16(3):436-40.
2005: Lawrence H Pinto; Martha Hotz Vitaterna; Kazuhiro Shimomura; Sandra M Siepka; Erin L McDearmon; Deborah Fenner; Stephen Lumayag; Chiaki Omura; Anne W Andrews; Matthew Baker; Brandon M Invergo; Marissa A Olvera; Edward Heffron; robert Mullins; Val C Sheffield; Edwin M Stone; Joseph S Takahashi
Generation, characterization, and molecular cloning of the Noerg-1 mutation of rhodopsin in the mouse.
Visual neuroscience 2005;22(5):619-29.
2005: Joseph A Brzezinski; Nadean L Brown; Atsuhiro Tanikawa; Ronald A Bush; Paul Sieving; Martha Hotz Vitaterna; Joseph S Takahashi; Thomas M Glaser
Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice.
Investigative ophthalmology & visual science 2005;46(7):2540-51.
2005: Marina P Antoch; Roman V Kondratov; Joseph S Takahashi
Circadian clock genes as modulators of sensitivity to genotoxic stress.
Cell cycle (Georgetown, Tex.) 2005;4(7):901-7.
2005: Colleen A McClung; Kyriaki Sidiropoulou; Martha Hotz Vitaterna; Joseph S Takahashi; Francis J White; Donald C Cooper; Eric J Nestler
Regulation of dopaminergic transmission and cocaine reward by the Clock gene.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(26):9377-81.
2005: Fred W Turek; Corinne Joshu; Akira Kohsaka; Emily Lin; Ganka Ivanova; Erin L McDearmon; Aaron D Laposky; Susan Losee Olson; Amy Easton; Dalan R Jensen; Robert H Eckel; Joseph S Takahashi; Joseph Bass
Obesity and metabolic syndrome in circadian Clock mutant mice.
Science (New York, N.Y.) 2005;308(5724):1043-5.
2005: Victoria Y Gorbacheva; Roman V Kondratov; Renliang Zhang; Srujana Cherukuri; Andrei V Gudkov; Joseph S Takahashi; Marina P Antoch
Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(9):3407-12.
2005: Seung-Hee Yoo; Caroline Ko; Phillip L Lowrey; Ethan D Buhr; Eun-joo Song; Suhwan Chang; Ook Joon Yoo; Shin Yamazaki; Choogon Lee; Joseph S Takahashi
A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(7):2608-13.
2005: Laura M Prolo; Joseph S Takahashi; Erik D Herzog
Circadian rhythm generation and entrainment in astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005;25(2):404-8.
2005: Sharon S Low; Joseph S Takahashi
Mouse chimeras and their application to circadian biology.
Methods in enzymology 2005;393():478-92.
2005: Sandra M Siepka; Joseph S Takahashi
Methods to record circadian rhythm wheel running activity in mice.
Methods in enzymology 2005;393():230-9.
2005: Sandra M Siepka; Joseph S Takahashi
Forward genetic screens to identify circadian rhythm mutants in mice.
Methods in enzymology 2005;393():219-29.
2004: David K Welsh; Seung-Hee Yoo; Andrew C Liu; Joseph S Takahashi; Steve A Kay
Bioluminescence imaging of individual fibroblasts reveals persistent, independently phased circadian rhythms of clock gene expression.
Current biology : CB 2004;14(24):2289-95.
2004: Dan Goldowitz; Wayne N Frankel; Joseph S Takahashi; Martha Holtz-Vitaterna; Carol Bult; Warren Kibbe; Jay Snoddy; Yanxia Li; Stephanie Pretel; Jeana Yates; Douglas J Swanson
Large-scale mutagenesis of the mouse to understand the genetic bases of nervous system structure and function.
Brain research. Molecular brain research 2004;132(2):105-15.
2004: Gérard Triqueneaux; Sandrine Thenot; Tomoko Kakizawa; Marina P Antoch; Rachid Safi; Joseph S Takahashi; Franck Delaunay; Vincent Laudet
The orphan receptor Rev-erbalpha gene is a target of the circadian clock pacemaker.
Journal of molecular endocrinology 2004;33(3):585-608.
2004: Lawrence H Pinto; Martha Hotz Vitaterna; Sandra M Siepka; Kazuhiro Shimomura; Stephen Lumayag; Matthew Baker; Deborah Fenner; robert Mullins; Val C Sheffield; Edwin M Stone; Edward Heffron; Joseph S Takahashi
Results from screening over 9000 mutation-bearing mice for defects in the electroretinogram and appearance of the fundus.
Vision research 2004;44(28):3335-45.
2004: Joseph S Takahashi
Finding new clock components: past and future.
Journal of biological rhythms 2004;19(5):339-47.
2004: Amander T Clark; Dan Goldowitz; Joseph S Takahashi; Martha Hotz Vitaterna; Sandra M Siepka; Luanne L Peters; Wayne N Frankel; George A Carlson; Janet Rossant; Joseph H Nadeau; Monica J Justice
Implementing large-scale ENU mutagenesis screens in North America.
Genetica 2004;122(1):51-64.
2004: Brooke H Miller; Susan Losee Olson; Fred W Turek; Jon E Levine; Teresa H Horton; Joseph S Takahashi
Circadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy.
Current biology : CB 2004;14(15):1367-73.
2004: Carol Bult; Warren Kibbe; Jay Snoddy; Martha Hotz Vitaterna; Doug Swanson; Stephanie Pretel; Yanxia Li; Moses M Hohman; Eugene Rinchik; Joseph S Takahashi; Wayne N Frankel; Dan Goldowitz
A genome end-game: understanding gene function in the nervous system.
Nature neuroscience 2004;7(5):484-5.
2004: Seung-Hee Yoo; Shin Yamazaki; Phillip L Lowrey; Kazuhiro Shimomura; Caroline Ko; Ethan D Buhr; Sandra M Siepka; Hee-Kyung Hong; Won Jun Oh; Ook Joon Yoo; Michael Menaker; Joseph S Takahashi
PERIOD2::LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(15):5339-46.
2004: Daniel E Kolker; Martha Hotz Vitaterna; Ethan M Fruechte; Joseph S Takahashi; Fred W Turek
Effects of age on circadian rhythms are similar in wild-type and heterozygous Clock mutant mice.
Neurobiology of aging 2004;25(4):517-23.
2004: Hee-Kyung Hong; Aravinda Chakravarti; Joseph S Takahashi
The gene for soluble N-ethylmaleimide sensitive factor attachment protein alpha is mutated in hydrocephaly with hop gait (hyh) mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(6):1748-53.
2004: Phillip L Lowrey; Joseph S Takahashi
Mammalian circadian biology: elucidating genome-wide levels of temporal organization.
Annual review of genomics and human genetics 2004;5():407-41.
2003: Daniel E Kolker; Hiroo Fukuyama; David S Huang; Joseph S Takahashi; Teresa H Horton; Fred W Turek
Aging alters circadian and light-induced expression of clock genes in golden hamsters.
Journal of biological rhythms 2003;18(2):159-69.
2003: Alexander C Zambon; Erin L McDearmon; Nathan Salomonis; Karen Vranizan; Kirsten L Johansen; Deborah Adey; Joseph S Takahashi; Morris Schambelan; Bruce R Conklin
Time- and exercise-dependent gene regulation in human skeletal muscle.
Genome biology 2003;4(10):R61.
2002: Satchidananda Panda; Marina P Antoch; Brooke H Miller; Andrew Su; Andrew B Schook; Marty Straume; Peter G Schultz; Steve A Kay; Joseph S Takahashi; John B Hogenesch
Coordinated transcription of key pathways in the mouse by the circadian clock.
Cell 2002;109(3):307-20.
2002: Lisa D Wilsbacher; Shin Yamazaki; Erik D Herzog; Eun-joo Song; Laurel A Radcliffe; Michikazu Abe; Gene Block; Edward Spitznagel; Michael Menaker; Joseph S Takahashi
Photic and circadian expression of luciferase in mPeriod1-luc transgenic mice invivo.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(1):489-94.
2001: Kathryn J Reid; Anne-Marie Chang; Margarita L Dubocovich; Fred W Turek; Joseph S Takahashi; Phyllis C Zee
Familial advanced sleep phase syndrome.
Archives of neurology 2001;58(7):1089-94.
2001: Kazuhiro Shimomura; Sharon S Low; DP King; TD Steeves; A Whiteley; J Kushla; P D Zemenides; A Lin; Martha Hotz Vitaterna; Gary Churchill; Joseph S Takahashi
Genome-wide epistatic interaction analysis reveals complex genetic determinants of circadian behavior in mice.
Genome research 2001;11(6):959-80.
2001: Sharon S Low; Joseph S Takahashi
Chimera analysis of the Clock mutation in mice shows that complex cellular integration determines circadian behavior.
Cell 2001;105(1):25-42.
2001: Martha Hotz Vitaterna; Joseph S Takahashi; Fred W Turek
Overview of circadian rhythms.
Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 2001;25(2):85-93.
2000: Maureen K Bunger; Lisa D Wilsbacher; Susan M Moran; CJ Clendenin; Laurel A Radcliffe; JB Hogenesch; M Celeste Simon; Joseph S Takahashi; Christopher A Bradfield
Mop3 is an essential component of the master circadian pacemaker in mammals.
Cell 2000;103(7):1009-17.
2000: Lisa D Wilsbacher; AM Sangoram; Marina P Antoch; Joseph S Takahashi
The mouse Clock locus: sequence and comparative analysis of 204 kb from mouse chromosome 5.
Genome research 2000;10(12):1928-40.
2000: Elizabeth M Naylor; Bernard M Bergmann; K Krauski; Phyllis C Zee; Joseph S Takahashi; Martha Hotz Vitaterna; Fred W Turek
The circadian clock mutation alters sleep homeostasis in the mouse.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(21):8138-43.
2000: JB Hogenesch; YZ Gu; Susan M Moran; K Shimomura; Laurel A Radcliffe; Joseph S Takahashi; Christopher A Bradfield
The basic helix-loop-helix-PAS protein MOP9 is a brain-specific heterodimeric partner of circadian and hypoxia factors.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2000;20(13):RC83.
2000: VS Valentinuzzi; Orfeu M Buxton; Anne-Marie Chang; K Scarbrough; EA Ferrari; Joseph S Takahashi; Fred W Turek
Locomotor response to an open field during C57BL/6J active and inactive phases: differences dependent on conditions of illumination.
Physiology & behavior 2000;69(3):269-75.
2000: Phillip L Lowrey; Kazuhiro Shimomura; Marina P Antoch; Shin Yamazaki; P D Zemenides; M R Ralph; Michael Menaker; Joseph S Takahashi
Positional syntenic cloning and functional characterization of the mammalian circadian mutation tau.
Science (New York, N.Y.) 2000;288(5465):483-92.
2000: Etienne Challet; Joseph S Takahashi; Fred W Turek
Nonphotic phase-shifting in clock mutant mice.
Brain research 2000;859(2):398-403.
2000: H Zhu; Silvia I LaRue; A Whiteley; TD Steeves; Joseph S Takahashi; Carla B Green
The Xenopus clock gene is constitutively expressed in retinal photoreceptors.
Brain research. Molecular brain research 2000;75(2):303-8.
2000: Phillip L Lowrey; Joseph S Takahashi
Genetics of the mammalian circadian system: Photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation.
Annual review of genetics 2000;34():533-562.
1999: Martha Hotz Vitaterna; Christopher P Selby; T Todo; H Niwa; Carol Thompson; Ethan M Fruechte; K Hitomi; Randy J Thresher; T Ishikawa; J Miyazaki; Joseph S Takahashi; Aziz Sancar
Differential regulation of mammalian period genes and circadian rhythmicity by cryptochromes 1 and 2.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(21):12114-9.
1999: Joseph S Takahashi
Narcolepsy genes wake up the sleep field.
Science (New York, N.Y.) 1999;285(5436):2076-7.
1999: Seung Hahm; Tooru M Mizuno; T J Wu; JP Wisor; Catherine A Priest; C A Kozak; Carol N Boozer; B Peng; R C McEvoy; P Good; Kevin A Kelley; Joseph S Takahashi; JE Pintar; James Roberts; Charles V Mobbs; Stephen R J Salton
Targeted deletion of the Vgf gene indicates that the encoded secretory peptide precursor plays a novel role in the regulation of energy balance.
Neuron 1999;23(3):537-48.
1999: TD Steeves; DP King; Y Zhao; AM Sangoram; F Du; A M Bowcock; R Y Moore; Joseph S Takahashi
Molecular cloning and characterization of the human CLOCK gene: expression in the suprachiasmatic nuclei.
Genomics 1999;57(2):189-200.
1998: Y Zhang; George C Brainard; P C Zee; L H Pinto; Joseph S Takahashi; F W Turek
Effects of aging on lens transmittance and retinal input to the suprachiasmatic nucleus in golden hamsters.
Neuroscience letters 1998;258(3):167-70.
1998: Erik D Herzog; Joseph S Takahashi; Gene D Block
Clock controls circadian period in isolated suprachiasmatic nucleus neurons.
Nature neuroscience 1998;1(8):708-13.
1998: S S Nikaido; Joseph S Takahashi
Day/night differences in the stimulation of adenylate cyclase activity by calcium/calmodulin in chick pineal cell cultures: evidence for circadian regulation of cyclic AMP.
Journal of biological rhythms 1998;13(6):479-93.
1998: Randy J Thresher; Martha Hotz Vitaterna; Y Miyamoto; A Kazantsev; DS Hsu; C Petit; Christopher P Selby; L Dawut; Oliver Smithies; Joseph S Takahashi; Aziz Sancar
Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses.
Science (New York, N.Y.) 1998;282(5393):1490-4.
1998: AM Sangoram; Lino Saez; Marina P Antoch; Nicholas Gekakis; David Staknis; A Whiteley; Ethan M Fruechte; Martha Hotz Vitaterna; Kazuhiro Shimomura; D P King; Michael W Young; Charles J Weitz; Joseph S Takahashi
Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription.
Neuron 1998;21(5):1101-13.
1998: Marianna Max; Arjun Surya; Joseph S Takahashi; Robert Margolskee; Barry E Knox
Light-dependent activation of rod transducin by pineal opsin.
The Journal of biological chemistry 1998;273(41):26820-6.
1998: Lisa D Wilsbacher; Joseph S Takahashi
Circadian rhythms: molecular basis of the clock.
Current opinion in genetics & development 1998;8(5):595-602.
1998: VS Valentinuzzi; Daniel E Kolker; Martha Hotz Vitaterna; Kazuhiro Shimomura; A Whiteley; Sharon S Low; Fred W Turek; EA Ferrari; R Paylor; Joseph S Takahashi
Automated measurement of mouse freezing behavior and its use for quantitative trait locus analysis of contextual fear conditioning in (BALB/cJ x C57BL/6J)F2 mice.
Learning & memory (Cold Spring Harbor, N.Y.) 1998;5(4-5):391-403.
1998: K Shimomura; JM Kornhauser; JP Wisor; T Umezu; S Yamazaki; NL Ihara; Joseph S Takahashi; Michael Menaker
Circadian behavior and plasticity of light-induced c-fos expression in SCN of tau mutant hamsters.
Journal of biological rhythms 1998;13(4):305-14.
1998: TK Darlington; KA Wager-Smith; M Fernanda Ceriani; David Staknis; Nicholas Gekakis; TD Steeves; Charles J Weitz; Joseph S Takahashi; Steve A Kay
Closing the circadian loop: CLOCK-induced transcription of its own inhibitors per and tim.
Science (New York, N.Y.) 1998;280(5369):1599-603.
1998: Nicholas Gekakis; David Staknis; H B Nguyen; Fred C Davis; Lisa D Wilsbacher; DP King; Joseph S Takahashi; Charles J Weitz
Role of the CLOCK protein in the mammalian circadian mechanism.
Science (New York, N.Y.) 1998;280(5369):1564-9.
1997: VS Valentinuzzi; K Scarbrough; Joseph S Takahashi; Fred W Turek
Effects of aging on the circadian rhythm of wheel-running activity in C57BL/6 mice.
The American journal of physiology 1997;273(6 Pt 2):R1957-64.
1997: R K Barrett; Joseph S Takahashi
Lability of circadian pacemaker amplitude in chick pineal cells: a temperature-dependent process.
Journal of biological rhythms 1997;12(4):309-18.
1997: DP King; Martha Hotz Vitaterna; Anne-Marie Chang; W F Dove; Lawrence H Pinto; Fred W Turek; Joseph S Takahashi
The mouse Clock mutation behaves as an antimorph and maps within the W19H deletion, distal of Kit.
Genetics 1997;146(3):1049-60.
1997: J T Lin; JM Kornhauser; N P Singh; Kelly E Mayo; Joseph S Takahashi
Visual sensitivities of nur77 (NGFI-B) and zif268 (NGFI-A) induction in the suprachiasmatic nucleus are dissociated from c-fos induction and behavioral phase-shifting responses.
Brain research. Molecular brain research 1997;46(1-2):303-10.
1997: Marina P Antoch; Eun-joo Song; Anne-Marie Chang; Martha Hotz Vitaterna; Y Zhao; Lisa D Wilsbacher; AM Sangoram; DP King; Lawrence H Pinto; Joseph S Takahashi
Functional identification of the mouse circadian Clock gene by transgenic BAC rescue.
Cell 1997;89(4):655-67.
1997: DP King; Y Zhao; AM Sangoram; Lisa D Wilsbacher; M Tanaka; Marina P Antoch; TD Steeves; Martha Hotz Vitaterna; JM Kornhauser; Phillip L Lowrey; Fred W Turek; Joseph S Takahashi
Positional cloning of the mouse circadian clock gene.
Cell 1997;89(4):641-53.
1997: JP Wisor; Joseph S Takahashi
Regulation of the vgf gene in the golden hamster suprachiasmatic nucleus by light and by the circadian clock.
The Journal of comparative neurology 1997;378(2):229-38.
1996: Y Zhang; Joseph S Takahashi; Fred W Turek
Critical period for cycloheximide blockade of light-induced phase advances of the circadian locomotor activity rhythm in golden hamsters.
Brain research 1996;740(1-2):285-90.
1996: J C Florez; K J Seidenman; R K Barrett; AM Sangoram; Joseph S Takahashi
Molecular cloning of chick pineal tryptophan hydroxylase and circadian oscillation of its mRNA levels.
Brain research. Molecular brain research 1996;42(1):25-30.
1996: J C Florez; Joseph S Takahashi
Quantitative two-dimensional gel electrophoretic analysis of clock-controlled proteins in cultured chick pineal cells: circadian regulation of tryptophan hydroxylase.
Journal of biological rhythms 1996;11(3):241-57.
1996: J C Florez; Joseph S Takahashi
Regulation of tryptophan hydroxylase by cyclic AMP, calcium, norepinephrine, and light in cultured chick pineal cells.
Journal of neurochemistry 1996;67(1):242-50.
1996: Jon M Kornhauser; Kelly E Mayo; Joseph S Takahashi
Light, immediate-early genes, and circadian rhythms.
Behavior genetics 1996;26(3):221-40.
1996: S S Nikaido; Joseph S Takahashi
Calcium modulates circadian variation in cAMP-stimulated melatonin in chick pineal cells.
Brain research 1996;716(1-2):1-10.
1996: Y Zhang; Jon M Kornhauser; Phyllis C Zee; Kelly E Mayo; Joseph S Takahashi; Fred W Turek
Effects of aging on light-induced phase-shifting of circadian behavioral rhythms, fos expression and CREB phosphorylation in the hamster suprachiasmatic nucleus.
Neuroscience 1996;70(4):951-61.
1996: DP King; Joseph S Takahashi
Forward genetic approaches to circadian clocks in mice.
Cold Spring Harbor symposia on quantitative biology 1996;61():295-302.
1996: Jon M Kornhauser; David D Ginty; Michael E Greenberg; Kelly E Mayo; Joseph S Takahashi
Light entrainment and activation of signal transduction pathways in the SCN.
Progress in brain research 1996;111():133-46.
1996: Joseph S Takahashi
The biological clock: it's all in the genes.
Progress in brain research 1996;111():5-9.
1995: J C Florez; Joseph S Takahashi
The circadian clock: from molecules to behaviour.
Annals of medicine 1995;27(4):481-90.
1995: R K Barrett; Joseph S Takahashi
Temperature compensation and temperature entrainment of the chick pineal cell circadian clock.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(8):5681-92.
1995: Fred W Turek; Lawrence H Pinto; Martha Hotz Vitaterna; PD Penev; Phyllis C Zee; Joseph S Takahashi
Pharmacological and genetic approaches for the study of circadian rhythms in mammals.
Frontiers in neuroendocrinology 1995;16(3):191-223.
1995: Marianna Max; Peter J McKinnon; K J Seidenman; R K Barrett; M L Applebury; Joseph S Takahashi; Robert Margolskee
Pineal opsin: a nonvisual opsin expressed in chick pineal.
Science (New York, N.Y.) 1995;267(5203):1502-6.
1995: J L Janavs; J C Florez; M E Pierce; Joseph S Takahashi
Forskolin and camptothecin induce a 30 kDa protein associated with melatonin production in Y79 human retinoblastoma cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1995;15(1 Pt 1):298-309.
1995: Fred W Turek; PD Penev; Y Zhang; O Van Reeth; Joseph S Takahashi; Phyllis C Zee
Alterations in the circadian system in advanced age.
Ciba Foundation symposium 1995;183():212-26; discussion 226-34.
1995: Joseph S Takahashi
Molecular neurobiology and genetics of circadian rhythms in mammals.
Annual review of neuroscience 1995;18():531-53.
1994: L M Besecke; Andrew Wolfe; M E Pierce; Joseph S Takahashi; Jon E Levine
Neuropeptide Y stimulates luteinizing hormone-releasing hormone release from superfused hypothalamic GT1-7 cells.
Endocrinology 1994;135(4):1621-7.
1994: H Sheshberadaran; Joseph S Takahashi
Characterization of the chicken rhodopsin promoter: identification of retina-specific and glass-like protein binding domains.
Molecular and cellular neurosciences 1994;5(4):309-18.
1994: Joseph S Takahashi; Lawrence H Pinto; Martha Hotz Vitaterna
Forward and reverse genetic approaches to behavior in the mouse.
Science (New York, N.Y.) 1994;264(5166):1724-33.
1994: Martha Hotz Vitaterna; DP King; Anne-Marie Chang; Jon M Kornhauser; P L Lowrey; J D McDonald; William F Dove; Lawrence H Pinto; Fred W Turek; Joseph S Takahashi
Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior.
Science (New York, N.Y.) 1994;264(5159):719-25.
1994: J L Janavs; M E Pierce; Joseph S Takahashi
RNA synthesis inhibitors increase melatonin production in Y79 human retinoblastoma cells.
Brain research. Molecular brain research 1994;23(1-2):47-56.
1994: Joseph S Takahashi
Circadian rhythms. ICER is nicer at night (sir!).
Current biology : CB 1994;4(2):165-8.
1993: Y Zhang; O Van Reeth; Phyllis C Zee; Joseph S Takahashi; Fred W Turek
Fos protein expression in the circadian clock is not associated with phase shifts induced by a nonphotic stimulus, triazolam.
Neuroscience letters 1993;164(1-2):203-8.
1993: Y Zhang; Phyllis C Zee; J D Kirby; Joseph S Takahashi; Fred W Turek
A cholinergic antagonist, mecamylamine, blocks light-induced fos immunoreactivity in specific regions of the hamster suprachiasmatic nucleus.
Brain research 1993;615(1):107-12.
1993: David D Ginty; Jon M Kornhauser; M A Thompson; H Bading; Kelly E Mayo; Joseph S Takahashi; Michael E Greenberg
Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock.
Science (New York, N.Y.) 1993;260(5105):238-41.
1993: Joseph S Takahashi
Circadian-clock regulation of gene expression.
Current opinion in genetics & development 1993;3(2):301-9.
1993: M E Pierce; H Sheshberadaran; Z Zhang; L E Fox; M L Applebury; Joseph S Takahashi
Circadian regulation of iodopsin gene expression in embryonic photoreceptors in retinal cell culture.
Neuron 1993;10(4):579-84.
1993: Joseph S Takahashi; Jon M Kornhauser; C Koumenis; Arnold Eskin
Molecular approaches to understanding circadian oscillations.
Annual review of physiology 1993;55():729-53.
1992: Joseph S Takahashi
Circadian clock genes are ticking.
Science (New York, N.Y.) 1992;258(5080):238-40.
1992: R D Smith; Fred W Turek; Joseph S Takahashi
Two families of phase-response curves characterize the resetting of the hamster circadian clock.
The American journal of physiology 1992;262(6 Pt 2):R1149-53.
1992: Jon M Kornhauser; D E Nelson; Kelly E Mayo; Joseph S Takahashi
Regulation of jun-B messenger RNA and AP-1 activity by light and a circadian clock.
Science (New York, N.Y.) 1992;255(5051):1581-4.
1991: D E Nelson; Joseph S Takahashi
Comparison of visual sensitivity for suppression of pineal melatonin and circadian phase-shifting in the golden hamster.
Brain research 1991;554(1-2):272-7.
1991: J L Janavs; M E Pierce; Joseph S Takahashi
N-acetyltransferase and protein synthesis modulate melatonin production by Y79 human retinoblastoma cells.
Brain research 1991;540(1-2):138-44.
1990: Jon M Kornhauser; D E Nelson; Kelly E Mayo; Joseph S Takahashi
Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus.
Neuron 1990;5(2):127-34.
1990: J J Milette; Joseph S Takahashi; Fred W Turek
Photic threshold for stimulation of testicular growth and pituitary FSH release in male Djungarian hamsters.
Brain research 1990;512(2):304-8.
1989: S S Nikaido; Joseph S Takahashi
Twenty-four hour oscillation of cAMP in chick pineal cells: role of cAMP in the acute and circadian regulation of melatonin production.
Neuron 1989;3(5):609-19.
1989: B L Pratt; Joseph S Takahashi
Vasoactive intestinal polypeptide and alpha 2-adrenoceptor agonists regulate adenosine 3',5'-monophosphate accumulation and melatonin release in chick pineal cell cultures.
Endocrinology 1989;125(5):2375-84.
1989: F Wollnik; Fred W Turek; P Majewski; Joseph S Takahashi
Phase shifting the circadian clock with cycloheximide: response of hamsters with an intact or a split rhythm of locomotor activity.
Brain research 1989;496(1-2):82-8.
1989: M E Pierce; D Barker; J Harrington; Joseph S Takahashi
Cyclic AMP-dependent melatonin production in Y79 human retinoblastoma cells.
Journal of neurochemistry 1989;53(1):307-10.
1989: Joseph S Takahashi; D E Nelson; Arnold Eskin
Immunocytochemical localization of serotonergic fibers innervating the ocular circadian system of Aplysia.
Neuroscience 1989;28(1):139-47.
1989: Joseph S Takahashi; N Murakami; S S Nikaido; B L Pratt; L M Robertson
The avian pineal, a vertebrate model system of the circadian oscillator: cellular regulation of circadian rhythms by light, second messengers, and macromolecular synthesis.
Recent progress in hormone research 1989;45():279-348; discussion 348-52.
1988: S T Inouye; Joseph S Takahashi; F Wollnik; Fred W Turek
Inhibitor of protein synthesis phase shifts a circadian pacemaker in mammalian SCN.
The American journal of physiology 1988;255(6 Pt 2):R1055-8.
1988: B L Pratt; Joseph S Takahashi
A pertussis toxin-sensitive G-protein mediates the alpha 2-adrenergic receptor inhibition of melatonin release in photoreceptive chick pineal cell cultures.
Endocrinology 1988;123(1):277-83.
1988: L M Robertson; Joseph S Takahashi
Circadian clock in cell culture: II. In vitro photic entrainment of melatonin oscillation from dissociated chick pineal cells.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(1):22-30.
1988: L M Robertson; Joseph S Takahashi
Circadian clock in cell culture: I. Oscillation of melatonin release from dissociated chick pineal cells in flow-through microcarrier culture.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1988;8(1):12-21.
1987: B L Pratt; Joseph S Takahashi
Alpha-2 adrenergic regulation of melatonin release in chick pineal cell cultures.
The Journal of neuroscience : the official journal of the Society for Neuroscience 1987;7(11):3665-74.