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Mika Takahashi

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Mariko Matsumoto; Atsushi Ono; Mika Senuma; Mika Takahashi; Hiromasa Takashima; Makiko Yamaguchi; Kazuhito Yokoyama; Yuka Yoshida; Mutsuko Hirata-Koizumi; Hina Kato; Tomoko Kawamura; Akihiko Hirose
An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test.
Mika Takahashi; Kaoru Yabe; Mutsuko Hirata-Koizumi; Hina Kato; Tomoko Kawamura; Mariko Matsumoto; Atsushi Ono; Akihiko Hirose
Reproductive and developmental toxicity screening test of 3-cyanopyridine in rats.
Atsushi Ono; Kyoko Sato; Mika Takahashi; Masami Yamada; Takeshi Yamazaki; Eiichi Kamata; Tomoko Kawamura; Yoshiharu Mirokuji; Hiroyuki Okamura; Takayuki Fukumoto; Akihiko Hirose; Masamitsu Honma
Validation of the (Q)SAR combination approach for mutagenicity prediction of flavor chemicals.

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2013: Mariko Matsumoto; Atsushi Ono; Mika Senuma; Mika Takahashi; Hiromasa Takashima; Makiko Yamaguchi; Kazuhito Yokoyama; Yuka Yoshida; Mutsuko Hirata-Koizumi; Hina Kato; Tomoko Kawamura; Akihiko Hirose
An antioxidant, N,N'-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2013;56():290-6.
2013: Mika Takahashi; Kaoru Yabe; Mutsuko Hirata-Koizumi; Hina Kato; Tomoko Kawamura; Mariko Matsumoto; Atsushi Ono; Akihiko Hirose
Reproductive and developmental toxicity screening test of 3-cyanopyridine in rats.
Reproductive toxicology (Elmsford, N.Y.) 2013;35():7-16.
2012: Atsushi Ono; Kyoko Sato; Mika Takahashi; Masami Yamada; Takeshi Yamazaki; Eiichi Kamata; Tomoko Kawamura; Yoshiharu Mirokuji; Hiroyuki Okamura; Takayuki Fukumoto; Akihiko Hirose; Masamitsu Honma
Validation of the (Q)SAR combination approach for mutagenicity prediction of flavor chemicals.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50(5):1538-46.
2012: Mutsuko Hirata-Koizumi; Tomoko Kawamura; Mariko Matsumoto; Atsushi Ono; Mika Takahashi; Akihiko Hirose
[Toxicity effects of phthalate substitute plasticizers used in toys].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 2012;(130):31-42.
2012: Mariko Matsumoto; Atsushi Ono; Hideki Serizawa; Masao Sunaga; Mika Takahashi; Mutsuko Hirata-Koizumi; Eiichi Kamata; Hina Kato; Akihiko Hirose
No toxicological effects on acute and repeated oral gavage doses of single-wall or multi-wall carbon nanotube in rats.
The Journal of toxicological sciences 2012;37(3):463-74.
2012: Mika Takahashi; Yuko Doi; Akihiro Hagiwara; Mutsuko Hirata-Koizumi; Hina Kato; Reiji Kubota; Tetsuji Nishimura; Atsushi Ono; Akihiko Hirose
Sub-acute oral toxicity study with fullerene C60 in rats.
The Journal of toxicological sciences 2012;37(2):353-61.
2009: Mika Takahashi; Masao Sunaga; Mutsuko Hirata-Koizumi; Akihiko Hirose; Eiichi Kamata; Makoto Ema
Reproductive and developmental toxicity screening study of 2,4-dinitrophenol in rats.
Environmental toxicology 2009;24(1):74-81.
2008: Yoshiko Sugita-Konishi; Atsutaka Kubosaki; Mika Takahashi; B J Park; Toshitsugu Tanaka; Kosuke Takatori; Masao Hirose; Makoto Shibutani
Nivalenol and the targeting of the female reproductive system as well as haematopoietic and immune systems in rats after 90-day exposure through the diet.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 2008;25(9):1118-27.
2006: Mika Takahashi; Mutsuko Hirata-Koizumi; Nobuo Nishimura; Yoshihiko Ito; Masao Sunaga; Sakiko Fujii; Eiichi Kamata; Ryuichi Hasegawa; Makoto Ema
Susceptibility of newborn rats to 3-ethylphenol and 4-ethylphenol compared with that of young rats.
Congenital anomalies 2006;46(1):26-33.
2005: Makoto Hayashi; Eiichi Kamata; Akihiko Hirose; Mika Takahashi; Takeshi Morita; Makoto Ema
In silico assessment of chemical mutagenesis in comparison with results of Salmonella microsome assay on 909 chemicals.
Mutation research 2005;588(2):129-35.
2005: Mutsuko Hirata-Koizumi; Masao Hamamura; Hiromi Furukawa; Naemi Fukuda; Yoshihiko Ito; Yumi Wako; Kotaro Yamashita; Mika Takahashi; Eiichi Kamata; Makoto Ema; Ryuichi Hasegawa
Elevated susceptibility of newborn as compared with young rats to 2-tert-butylphenol and 2,4-di-tert-butylphenol toxicity.
Congenital anomalies 2005;45(4):146-53.
2005: Ryuichi Hasegawa; Mutsuko Hirata-Koizumi; Mika Takahashi; Eiichi Kamata; Makoto Ema
Comparative susceptibility of newborn and young rats to six industrial chemicals.
Congenital anomalies 2005;45(4):137-45.
2004: Akihiko Hirose; Ryuichi Hasegawa; Akiyoshi Nishikawa; Mika Takahashi; Makoto Ema
Revision and establishment of Japanese drinking water quality guidelines for di(2-ethylhexyl) phthalate, toluene and vinyl chloride -- differences from the latest WHO guideline drafts.
The Journal of toxicological sciences 2004;29(5):535-9.
2004: Mika Takahashi; Hidehiro Ogata; Hiroyuki Izumi; Kotaro Yamashita; Masato Takechi; Mutsuko Hirata-Koizumi; Eiichi Kamata; Ryuichi Hasegawa; Makoto Ema
Comparative toxicity study of 2,4,6-trinitrophenol (picric acid) in newborn and young rats.
Congenital anomalies 2004;44(4):204-14.
2002: Naoko Niho; Makoto Shibutani; Kazuhiro Toyoda; H Sato; Akihiko Hirose; K Imaida; Mika Takahashi; Y Hayashi; Masao Hirose
Dose- and time-response studies of sodium o-phenylphenate urinary bladder carcinogenicity in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2002;40(5):715-22.
2000: Kiyoshi Takegawa; Kunitoshi Mitsumori; Hiroshi Onodera; T Shimo; K Kitaura; Kazuo Yasuhara; Masao Hirose; Mika Takahashi
Studies on the carcinogenicity of potassium iodide in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(9):773-81.
2000: T Itoh; Takayoshi Suzuki; Akiyoshi Nishikawa; Fumio Furukawa; Mika Takahashi; W Xue; Toshio Sofuni; Makoto Hayashi
In vivo genotoxicity of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in lacI transgenic (Big Blue) mice.
Mutation research 2000;468(1):19-25.
2000: Fumio Furukawa; Akiyoshi Nishikawa; In Seon Lee; Hwa-Young Son; Hideaki Nakamura; Makoto Miyauchi; Mika Takahashi; Masao Hirose
Inhibition by methionine of pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl) amine.
Cancer letters 2000;152(2):163-7.
2000: Takayoshi Imazawa; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Takako Ikeda; Mika Takahashi; Masao Hirose
Lack of carcinogenicity of gardenia blue colour given chronically in the diet to F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(4):313-8.
2000: Fumio Furukawa; Akiyoshi Nishikawa; Hajimu Ishiwata; Mika Takahashi; Y Hayashi; Masao Hirose
Renal carcinogenicity of concurrently administered fish meal and sodium nitrite in F344 rats.
Japanese journal of cancer research : Gann 2000;91(2):139-47.
2000: Kazuhiro Toyoda; Makoto Shibutani; H Sato; Chikako Uneyama; Mika Takahashi; Y Hayashi; Masao Hirose
Lack of carcinogenicity and increased survival in F344 rats treated with 5-fluorouracil for two years.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2000;38(2-3):187-93.
2000: Takayoshi Imazawa; Kunitoshi Mitsumori; S Kitajima; Hiroshi Onodera; Toru Tamura; Mika Takahashi; Masao Hirose
Time course of ultrastructural changes and immunoelectron microscopic localization of neurocalcin in motor endplates of the lumbrical muscles of rats given a single administration of 2,5-di(tert-butyl)-1,4-hydroquinone.
Acta neuropathologica 2000;99(2):109-16.
1999: Toru Tamura; Makoto Shibutani; Kazuhiro Toyoda; T Shoda; K Takada; Chikako Uneyama; Mika Takahashi; Masao Hirose
Tumor-promoting activities of hydroquinone and 1,1-dimethylhydrazine after initiation of newborn mice with 1-methyl-1-nitrosourea.
Cancer letters 1999;143(1):71-80.
1999: Toru Tamura; Kunitoshi Mitsumori; Hiroshi Onodera; Mika Takahashi; T Funakoshi; Kazuo Yasuhara; Kiyoshi Takegawa; Hisayoshi Takagi; Masao Hirose
Time course observation of thyroid proliferative lesions and serum levels of related hormones in rats treated with kojic acid after DHPN initiation.
The Journal of toxicological sciences 1999;24(3):145-55.
1999: Makoto Miyauchi; Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; Hideaki Nakamura; Mika Takahashi; Masao Hirose
Carcinogenic risk assessment of MeIQx and PhIP in a newborn mouse two-stage tumorigenesis assay.
Cancer letters 1999;142(1):75-81.
1999: Toru Tamura; Kunitoshi Mitsumori; Hiroshi Onodera; N Fujimoto; Kazuo Yasuhara; Kiyoshi Takegawa; Mika Takahashi
Inhibition of thyroid iodine uptake and organification in rats treated with kojic acid.
Toxicological sciences : an official journal of the Society of Toxicology 1999;47(2):170-5.
1999: Fumio Furukawa; Akiyoshi Nishikawa; Ken-Ichiro Kasahara; In Seon Lee; K Wakabayashi; Mika Takahashi; Masao Hirose
Inhibition by beta-carotene of upper respiratory tumorigenesis in hamsters receiving diethylnitrosamine followed by cigarette smoke exposure.
Japanese journal of cancer research : Gann 1999;90(2):154-61.
1999: Ken-Ichiro Kasahara; Akiyoshi Nishikawa; Fumio Furukawa; S Ikezaki; Z Tanakamaru; Hisayoshi Takagi; Takako Ikeda; Takayoshi Imazawa; Mika Takahashi
Suppressive effects of josamycin on the development of altered liver cell foci and chronic nephropathy in a carcinogenicity study.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1999;37(1):61-7.
1999: Kunitoshi Mitsumori; Hiroshi Onodera; Mika Takahashi; T Funakoshi; Toru Tamura; Kazuo Yasuhara; Kiyoshi Takegawa; M Takahashi
Promoting effects of kojic acid due to serum TSH elevation resulting from reduced serum thyroid hormone levels on development of thyroid proliferative lesions in rats initiated with N-bis(2-hydroxypropyl)nitrosamine.
Carcinogenesis 1999;20(1):173-6.
1998: H Okamiya; Kunitoshi Mitsumori; H Onodera; S Ito; Takayoshi Imazawa; K Yasuhara; Mika Takahashi
Mechanistic study on liver tumor promoting effects of piperonyl butoxide in rats.
Archives of toxicology 1998;72(11):744-50.
1998: X Wang; Takayoshi Suzuki; T Itoh; Masamitsu Honma; Akiyoshi Nishikawa; Fumio Furukawa; Mika Takahashi; Makoto Hayashi; T Kato; Toshio Sofuni
Specific mutational spectrum of dimethylnitrosamine in the lacI transgene of Big Blue C57BL/6 mice.
Mutagenesis 1998;13(6):625-30.
1998: Kiyoshi Takegawa; Kunitoshi Mitsumori; Hiroshi Onodera; K Yasuhara; Mika Takahashi; T Yanai; T Masegi; Y Hayashi
Immunohistochemical studies of TSH-producing cells in the pituitary and expression of growth factors in thyroidal proliferative lesions in rats treated with thiourea and excess vitamin A.
The Journal of toxicological sciences 1998;23(3):213-21.
1998: T Shoda; Kunitoshi Mitsumori; Takayoshi Imazawa; Kazuhiro Toyoda; Toru Tamura; K Takada; Mika Takahashi
A spontaneous seminal vesicle adenocarcinoma in an aged F344 rat.
Toxicologic pathology 1998;26(3):448-51.
1998: Fumio Furukawa; Akiyoshi Nishikawa; Takayoshi Imazawa; Ken-Ichiro Kasahara; Mika Takahashi
Enhancing effects of quinacrine on development of hepatopancreatic lesions in N-nitrosobis(2-oxopropyl)amine-initiated hamsters.
Japanese journal of cancer research : Gann 1998;89(2):131-6.
1998: Kiyoshi Takegawa; Kunitoshi Mitsumori; Hiroshi Onodera; Kazuo Yasuhara; K Kitaura; T Shimo; Mika Takahashi
Induction of squamous cell carcinomas in the salivary glands of rats by potassium iodide.
Japanese journal of cancer research : Gann 1998;89(2):105-9.
1998: Akiyoshi Nishikawa; Z Tanakamura; Fumio Furukawa; In Seon Lee; Ken-Ichiro Kasahara; S Ikezaki; Mika Takahashi
Chemopreventive activity of oltipraz against induction of glandular stomach carcinogenesis in rats by N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis 1998;19(2):365-8.
1998: Kunitoshi Mitsumori; Takayoshi Imazawa; Hiroshi Onodera; Mika Takahashi; S Kitajima; Tohru Inoue; Yuji Kurokawa
Ultrastructural changes in motor endplates of the lumbrical muscles of rats induced by a microsomal Ca2+ ATPase inhibitor, 2,5-di(tert-butyl)-1,4-hydroquinone.
Archives of toxicology 1998;72(2):115-8.
1997: Akiyoshi Nishikawa; In Seon Lee; Chikako Uneyama; Fumio Furukawa; H C Kim; Ken-Ichiro Kasahara; N Huh; Mika Takahashi
Mechanistic insights into chemopreventive effects of phenethyl isothiocyanate in N-nitrosobis(2-oxopropyl)amine-treated hamsters.
Japanese journal of cancer research : Gann 1997;88(12):1137-42.
1997: T Shoda; Kazuhiro Toyoda; Chikako Uneyama; K Takada; Mika Takahashi
Lack of carcinogenicity of medium-viscosity liquid paraffin given in the diet to F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35(12):1181-90.
1997: Z Tanakamaru; Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; In Seon Lee; Ken-Ichiro Kasahara; T Tanaka; Mika Takahashi
Failure of dietary alpha-difluoromethylornithine to inhibit gastric carcinogenesis in rats after 8 weeks of treatment with N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride.
Cancer letters 1997;120(1):95-100.
1997: Kazuo Yasuhara; Kunitoshi Mitsumori; T Shimo; Hiroshi Onodera; Mika Takahashi; Y Hayashi
Mice with focal pulmonary fibrosis caused by monocrotaline are insensitive to urethane induction of lung tumorigenesis.
Toxicologic pathology 1997;25(6):574-81.
1997: Akiyoshi Nishikawa; Fumio Furukawa; Ken-Ichiro Kasahara; In Seon Lee; Takayoshi Suzuki; Makoto Hayashi; Toshio Sofuni; Mika Takahashi
Comparative study on organ-specificity of tumorigenicity, mutagenicity and cell proliferative activity induced by dimethylnitrosamine in Big Blue mice.
Cancer letters 1997;117(2):143-7.
1997: Kunitoshi Mitsumori; Hiroshi Onodera; T Shoda; Chikako Uneyama; Takayoshi Imazawa; Kiyoshi Takegawa; Kazuo Yasuhara; T Watanabe; Mika Takahashi
Liver tumour-promoting effects of oxfendazole in rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35(8):799-806.
1997: Kazuhiro Toyoda; H Matsui; T Shoda; Chikako Uneyama; K Takada; Mika Takahashi
Assessment of the carcinogenicity of stevioside in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35(6):597-603.
1997: Kazuo Yasuhara; T Shimo; Kunitoshi Mitsumori; Hiroshi Onodera; K Kitaura; Mika Takahashi
Lack of carcinogenicity of cyanoguanidine in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35(5):475-80.
1997: Fumio Furukawa; Akiyoshi Nishikawa; Tomonori Enami; M Mitsui; Takayoshi Imazawa; Z Tanakamaru; H C Kim; In Seon Lee; Ken-Ichiro Kasahara; Mika Takahashi
Promotional effects of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) on N-nitrosobis(2-oxopropyl)amine (BOP)-initiated carcinogenesis in hamsters.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35(3-4):387-92.
1997: Kazuhiro Toyoda; T Shoda; Chikako Uneyama; K Takada; Mika Takahashi
Carcinogenicity study of beta-cyclodextrin in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1997;35(3-4):331-6.
1997: Ken-Ichiro Kasahara; Fumio Furukawa; Akiyoshi Nishikawa; Z Tanakamaru; H C Kim; S Ikezaki; Mika Takahashi
[Effects of 16-week dietary administration of 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline in rats].
Kokuritsu Iyakuhin Shokuhin Eisei Kenkyūjo hōkoku = Bulletin of National Institute of Health Sciences 1997;(115):107-11.
1997: Kiyoshi Takegawa; Kunitoshi Mitsumori; Hiroshi Onodera; M Mutai; K Kitaura; M Takahashi; Chikako Uneyama; Kazuo Yasuhara; Mika Takahashi; T Yanai; Toshiaki Masegi; Y Hayashi
UDP-GT involvement in the enhancement of cell proliferation in thyroid follicular cell proliferative lesions in rats treated with thiourea and vitamin A.
Archives of toxicology 1997;71(11):661-7.
1996: Kazuo Yasuhara; Kunitoshi Mitsumori; Takayoshi Imazawa; H Yoshimura; Hiroshi Onodera; K Takegawa; Mika Takahashi; W Shirai; Y Hayashi
Ultrastructure and cell proliferative activities of karyomegalic alveolar epithelial cells in early pulmonary inflammatory lesions of Syrian golden hamsters induced by N-methyl-N-nitrosourethane.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 1996;58(9):825-31.
1996: S Ikezaki; Akiyoshi Nishikawa; Fumio Furukawa; T Enami; M Mitsui; Z Tanakamaru; H C Kim; In Seon Lee; Takayoshi Imazawa; Mika Takahashi
Long-term toxicity/carcinogenicity study of L-histidine monohydrochloride in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(8):687-91.
1996: S Ikezaki; Akiyoshi Nishikawa; Fumio Furukawa; Z Tanakamura; H C Kim; H Mori; Mika Takahashi
Chemopreventive effects of 24R,25-dihydroxyvitamin D3, a vitamin D3 derivative, on glandular stomach carcinogenesis induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride.
Cancer research 1996;56(12):2767-70.
1996: Akiyoshi Nishikawa; Fumio Furukawa; Chikako Uneyama; S Ikezaki; Z Tanakamaru; F L Chung; Mika Takahashi; Y Hayashi
Chemopreventive effects of phenethyl isothiocyanate on lung and pancreatic tumorigenesis in N-nitrosobis(2-oxopropyl)amine-treated hamsters.
Carcinogenesis 1996;17(6):1381-4.
1996: Kunitoshi Mitsumori; Hiroshi Onodera; M Takahashi; T Shimo; Kazuo Yasuhara; Kiyoshi Takegawa; Mika Takahashi; Y Hayashi
Promoting effect of large amounts of vitamin A on cell proliferation of thyroid proliferative lesions induced by simultaneous treatment with thiourea.
Cancer letters 1996;103(1):19-31.
1996: S Ikezaki; Akiyoshi Nishikawa; T Enami; Fumio Furukawa; Takayoshi Imazawa; Chikako Uneyama; S Fukushima; Mika Takahashi
Inhibitory effects of the dietary antioxidants butylated hydroxyanisole and butylated hydroxytoluene on bronchioloalveolar cell proliferation during the bleomycin-induced pulmonary fibrosing process in hamsters.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1996;34(4):327-35.
1996: Akiyoshi Nishikawa; Fumio Furukawa; S Ikezaki; Z Tanakamaru; F L Chung; Mika Takahashi; Y Hayashi
Chemopreventive effects of 3-phenylpropyl isothiocyanate on hamster lung tumorigenesis initiated with N-nitrosobis(2-oxopropyl)amine.
Japanese journal of cancer research : Gann 1996;87(2):122-6.
1996: Kiyoshi Takegawa; Kunitoshi Mitsumori; Hiroshi Onodera; T Shimo; Mika Takahashi; Kazuo Yasuhara; M Takahashi
[Modifying effects of goitrogens on the tumor development in the liver and lung of rats].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1996;(114):33-7.
1996: Takayoshi Imazawa; Akiyoshi Nishikawa; Fumio Furukawa; Z Tanakamaru; I S Lee; H C Kim; Mika Takahashi
[A 13-week subchronic toxicity study of gardenia blue in F344 rats].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1996;(114):27-32.
1996: Hiroshi Onodera; Kunitoshi Mitsumori; Chikako Uneyama; Kazuo Yasuhara; Kiyoshi Takegawa; Mika Takahashi
[Intensity of liver tumor promotion effects in rats given repeated oral administrations of benzimidazole compounds].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1996;(114):21-6.
1996: Takayoshi Suzuki; T Itoh; Makoto Hayashi; Y Nishikawa; S Ikezaki; Fumio Furukawa; Mika Takahashi; Toshio Sofuni
Organ variation in the mutagenicity of dimethylnitrosamine in Big Blue mice.
Environmental and molecular mutagenesis 1996;28(4):348-53.
1996: Kunitoshi Mitsumori; Kiyoshi Takegawa; T Shimo; Hiroshi Onodera; Kazuo Yasuhara; Mika Takahashi
Morphometric and immunohistochemical studies on atrophic changes in lympho-hematopoietic organs of rats treated with piperonyl butoxide or subjected to dietary restriction.
Archives of toxicology 1996;70(12):809-14.
1995: Chikako Uneyama; H Uneyama; Mika Takahashi; N Akaike
Pharmacological studies on mechanisms involved in Ca2+ oscillations in rat megakaryocytes.
European journal of pharmacology 1995;291(3):381-6.
1995: Akiyoshi Nishikawa; Fumio Furukawa; M Mitsui; T Enami; Takayoshi Imazawa; S Ikezaki; Mika Takahashi
Dose-dependent promotion effects of potassium chloride on glandular stomach carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine and the synergistic influence with sodium chloride.
Cancer research 1995;55(22):5238-41.
1995: H Ogasawara; K Imaida; H Ishiwata; Kazuhiro Toyoda; T Kawanishi; Chikako Uneyama; S Hayashi; Mika Takahashi; Y Hayashi
Urinary bladder carcinogenesis induced by melamine in F344 male rats: correlation between carcinogenicity and urolith formation.
Carcinogenesis 1995;16(11):2773-7.
1995: Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; S Ikezaki; T Otoshi; S Fukushima; Mika Takahashi
Cell proliferation in lung fibrosis-associated hyperplastic lesions.
Human & experimental toxicology 1995;14(9):701-5.
1995: Kazuo Yasuhara; Kunitoshi Mitsumori; H Yoshimura; Takayoshi Imazawa; S Hayashi; Hiroshi Onodera; Mika Takahashi; Y Hayashi
Relationship between the development of pulmonary fibrosis and lung tumors in Syrian golden hamsters induced by N-methyl-N-nitrosourethane.
Toxicologic pathology 1995;23(5):551-9.
1995: Mika Takahashi
Usefulness of in vivo short-term studies on carcinogenic risk assessment.
The Journal of toxicological sciences 1995;20(4):465-7.
1995: H Matsui; Kunitoshi Mitsumori; Kazuo Yasuhara; Hiroshi Onodera; T Shimo; Mika Takahashi
Morphological evaluation of cyclophosphamide testicular toxicity in rats using quantitative morphometry of spermatogenic cycle stages.
The Journal of toxicological sciences 1995;20(4):407-14.
1995: Kunitoshi Mitsumori; Hiroshi Onodera; Mika Takahashi; T Shimo; Kazuo Yasuhara; K Kitaura; M Takahashi; Y Hayashi
Effect of thyroid stimulating hormone on the development and progression of rat thyroid follicular cell tumors.
Cancer letters 1995;92(2):193-202.
1995: Chikako Uneyama; Takayoshi Imazawa; H Uneyama; N Akaike; T Kawanishi; Mika Takahashi
Not Ca2+ but CAMP is the second messenger for morphological changes in rat megakaryocyte.
Biochemical and biophysical research communications 1995;211(1):282-8.
1995: Kiyoshi Takegawa; Kazuo Yasuhara; Kunitoshi Mitsumori; Hiroshi Onodera; T Shimo; Mika Takahashi
[Toxicity in rats fed diet containing iron lactate for 26 weeks].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1995;(113):58-63.
1995: S Ikezaki; Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; M Mitsui; T Enami; Mika Takahashi
[A 13-week subchronic toxicity study of josamycin in F344 rats].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1995;(113):44-50.
1995: Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; S Ikezaki; T Hasegawa; Mika Takahashi
Effects of caffeine on glandular stomach carcinogenesis induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1995;33(1):21-6.
1995: Takayoshi Imazawa; Akiyoshi Nishikawa; M Tada; Mika Takahashi; Y Hayashi
Nucleolar segregation as an early marker for DNA damage; an experimental study in rats treated with 4-hydroxyaminoquinoline 1-oxide.
Virchows Archiv : an international journal of pathology 1995;426(3):295-300.
1994: Hiroshi Onodera; K Kitaura; Kunitoshi Mitsumori; J Yoshida; Kazuo Yasuhara; T Shimo; Mika Takahashi; Y Hayashi
Study on the carcinogenicity of tannic acid in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1994;32(12):1101-6.
1994: Hiroshi Onodera; Kunitoshi Mitsumori; Mika Takahashi; T Shimo; Kazuo Yasuhara; K Kitaura; M Takahashi; Y Hayashi
Thyroid proliferative lesions induced by anti-thyroid drugs in rats are not always accompanied by sustained increases in serum TSH.
The Journal of toxicological sciences 1994;19(4):227-34.
1994: Fumio Furukawa; Akiyoshi Nishikawa; H Yoshimura; M Mitsui; Takayoshi Imazawa; S Ikezaki; Mika Takahashi
Effects of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) on N-nitrosobis(2-oxopropyl)amine (BOP)-initiated carcinogenesis in hamsters.
Cancer letters 1994;86(1):75-82.
1994: Akiyoshi Nishikawa; Naohide Kinae; Fumio Furukawa; M Mitsui; T Enami; T Hasegawa; Mika Takahashi
Enhancing effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) on cell proliferation and lipid peroxidation in the rat gastric mucosa.
Cancer letters 1994;85(2):151-7.
1994: T Shimo; Kunitoshi Mitsumori; Hiroshi Onodera; Kazuo Yasuhara; Mika Takahashi; M Takahashi; Y Ueno; Y Hayashi
Time course observation of thyroid proliferative lesions and serum TSH levels in rats treated with thiourea after DHPN initiation.
Cancer letters 1994;85(2):141-9.
1994: Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; H Yoshimura; S Ikezaki; Y Hayashi; Mika Takahashi
Effects of cigarette smoke on N-nitrosobis(2-oxopropyl)amine-induced pancreatic and respiratory tumorigenesis in hamsters.
Japanese journal of cancer research : Gann 1994;85(10):1000-4.
1994: Chikako Uneyama; H Uneyama; Mika Takahashi; N Akaike
FCCP modulation of Ca2+ oscillation in rat megakaryocytes.
European journal of pharmacology 1994;268(3):455-8.
1994: Kazuhiro Toyoda; Akiyoshi Nishikawa; Fumio Furukawa; T Kawanishi; Y Hayashi; Mika Takahashi
Cell proliferation induced by laxatives and related compounds in the rat intestine.
Cancer letters 1994;83(1-2):43-9.
1994: Mika Takahashi; Akiyoshi Nishikawa; Fumio Furukawa; T Enami; T Hasegawa; Y Hayashi
Dose-dependent promoting effects of sodium chloride (NaCl) on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis 1994;15(7):1429-32.
1994: T Shimo; Kunitoshi Mitsumori; Hiroshi Onodera; Kazuo Yasuhara; K Kitaura; Mika Takahashi; J Kanno; Y Hayashi
Synergistic effects of phenobarbital and thiourea on proliferative lesions in the rat liver.
Cancer letters 1994;81(1):45-52.
1994: Chikako Uneyama; H Uneyama; Mika Takahashi; N Akaike
Biological actions of purines on rat megakaryocytes: potentiation by adenine of the purinoceptor-operated cytoplasmic Ca2+ oscillation.
British journal of pharmacology 1994;112(2):349-51.
1994: T Kawanishi; M Kawanishi; H Ohata; K Toyoda; Mika Takahashi; K Momose; Y Hayashi
The relationship between spontaneous calcium oscillations and cell proliferation in cultured smooth muscle cells.
Japanese journal of pharmacology 1994;65(1):59-62.
1994: M Sato; Fumio Furukawa; Akiyoshi Nishikawa; Kunitoshi Mitsumori; Takayoshi Imazawa; Mika Takahashi
Analysis of proliferative activity in renal lesions induced by N-nitrosobis(2-oxopropyl)amine (BOP) in male Syrian golden hamsters.
Cancer letters 1994;79(1):91-9.
1994: Takayoshi Imazawa; Fumio Furukawa; Makoto Shibutani; Kunitoshi Mitsumori; M Sato; Y Hayashi; Mika Takahashi
Correlation between nucleolar organizer regions and cell proliferation in pancreatic acinar cell proliferative lesions in rats.
Pancreas 1994;9(2):219-24.
1994: Hiroshi Onodera; Kunitoshi Mitsumori; Kazuo Yasuhara; T Shimo; N Kurokawa; Mika Takahashi
[13-week subchronic oral toxicity study of isopropyl p-hydroxybenzoate in F344 rats].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1994;(112):82-8.
1994: S Ikezaki; Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; T Enami; M Mitsui; Mika Takahashi
[13-week subchronic toxicity study of L-histidine monohydrochloride in F344 rats].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1994;(112):57-63.
1994: Kunitoshi Mitsumori; Fumio Furukawa; M Sato; H Yoshimura; Takayoshi Imazawa; Akiyoshi Nishikawa; Mika Takahashi
Promoting effects of ethinyl estradiol on development of renal proliferative lesions induced by N-nitrosobis (2-oxopropyl)amine in female Syrian golden hamsters.
Journal of cancer research and clinical oncology 1994;120(3):131-6.
1994: Fumio Furukawa; Akiyoshi Nishikawa; Takayoshi Imazawa; H Yoshimura; M Sato; Y Aze; Mika Takahashi
Blocking effects of synthetic trypsin inhibitor (camostat) on pancreatic carcinogenesis in hamsters initiated with N-nitrosobis(2-oxopropyl)amine.
Pancreas 1994;9(1):78-82.
1993: M Mitsui; Fumio Furukawa; M Sato; T Enami; Takayoshi Imazawa; Akiyoshi Nishikawa; Mika Takahashi
Carcinogenicity study of 1,1-bis(tert-butylperoxy)-3,3,5-trimethylcyclohexane in B6C3F1 mice.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(12):929-33.
1993: Chikako Uneyama; H Uneyama; Mika Takahashi; N Akaike
Cytoplasmic pH regulates ATP-induced Ca(2+)-dependent K(+)-current oscillation in rat megakaryocytes.
The Biochemical journal 1993;295 ( Pt 1)():317-20.
1993: Mika Takahashi; Kazuhiro Toyoda; Y Aze; K Furuta; Kunitoshi Mitsumori; Y Hayashi
The rat urinary bladder as a new target of heterocyclic amine carcinogenicity: tumor induction by 3-amino-1-methyl-5H-pyrido[4,3-b]indole acetate.
Japanese journal of cancer research : Gann 1993;84(8):852-8.
1993: Fumio Furukawa; Akiyoshi Nishikawa; K Imaida; Takayoshi Imazawa; K Shinoda; Mika Takahashi; Y Hayashi
Temporal dissociation between cell proliferation and eosinophilic foci development in the exocrine pancreas of rats initiated with 4-hydroxyaminoquinoline 1-oxide and administered soybean trypsin inhibitor.
Carcinogenesis 1993;14(4):607-10.
1993: Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; Kazuhiro Toyoda; M Mitsui; T Hasegawa; Mika Takahashi
Effects of hickory smoke condensate on gastric carcinogenesis in Wistar rats after treatment with N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1993;31(1):25-30.
1993: Y Aze; Kazuhiro Toyoda; Fumio Furukawa; Kunitoshi Mitsumori; Mika Takahashi
Enhancing effect of ethanol on esophageal tumor development in rats by initiation of diethylnitrosamine.
Carcinogenesis 1993;14(1):37-40.
1993: H Ogasawara; Kunitoshi Mitsumori; Hiroshi Onodera; Takayoshi Imazawa; Makoto Shibutani; Mika Takahashi; J M Ward; A Maekawa
Spontaneous histiocytic sarcoma with possible origin from the bone marrow and lymph node in Donryu and F-344 rats.
Toxicologic pathology 1993;21(1):63-70.
1992: Kazuhiro Toyoda; K Imaida; Kunitoshi Mitsumori; H Sato; A Maekawa; Hiroshi Onodera; Mika Takahashi
Correlation between cataract and retinopathy due to lighting in F344 rats used in a long-term carcinogenicity study.
Journal of toxicology and environmental health 1992;37(4):495-509.
1992: Fumio Furukawa; Akiyoshi Nishikawa; K Imaida; M Mitsui; T Enami; Y Hayashi; Mika Takahashi
Inhibitory effects of crude soybean trypsin inhibitor on pancreatic ductal carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine.
Carcinogenesis 1992;13(11):2133-5.
1992: M Sato; Fumio Furukawa; Kazuhiro Toyoda; Kunitoshi Mitsumori; Akiyoshi Nishikawa; Mika Takahashi
Lack of carcinogenicity of ferric chloride in F344 rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 1992;30(10):837-42.
1992: Akiyoshi Nishikawa; Fumio Furukawa; Takayoshi Imazawa; H Yoshimura; Kunitoshi Mitsumori; Mika Takahashi
Effects of caffeine, nicotine, ethanol and sodium selenite on pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine.
Carcinogenesis 1992;13(8):1379-82.
1992: Akiyoshi Nishikawa; Fumio Furukawa; M Mitsui; T Enami; T Kawanishi; T Hasegawa; Mika Takahashi
Inhibitory effect of calcium chloride on gastric carcinogenesis in rats after treatment with N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride.
Carcinogenesis 1992;13(7):1155-8.
1992: Mika Takahashi; K Imaida; Kunitoshi Mitsumori; H Okamiya; K Shinoda; H Yoshimura; Fumio Furukawa; Y Hayashi
Promoting effects of cigarette smoke on the respiratory tract carcinogenesis of Syrian golden hamsters treated with diethylnitrosamine.
Carcinogenesis 1992;13(4):569-72.
1992: K Imaida; Chikako Uneyama; H Ogasawara; S Hayashi; K Fukuhara; Naoki Miyata; Mika Takahashi
Induction of colon adenocarcinomas in CD rats and lung adenomas in ICR mice by 6-nitrochrysene: comparison of carcinogenicity and aryl hydrocarbon hydroxylase induction in the target organs of each species.
Cancer research 1992;52(6):1542-5.
1992: Fumio Furukawa; H Sato; K Imaida; Kazuhiro Toyoda; Takayoshi Imazawa; Mika Takahashi; Y Hayashi
Induction of pancreatic tumors in male Syrian golden hamsters by intraperitoneal N-methyl-N-nitrosourea injection.
Pancreas 1992;7(2):153-8.
1992: Fumio Furukawa; K Imaida; Takayoshi Imazawa; Y Hayashi; Mika Takahashi
Modifying effects of soybean trypsin inhibitor on development of eosinophilic nodules and basophilic foci in the exocrine pancreas of male Sprague-Dawley rats treated with 4-hydroxyaminoquinoline 1-oxide.
Japanese journal of cancer research : Gann 1992;83(1):40-4.
1992: M Mitsui; Fumio Furukawa; J Suzuki; T Enami; Akiyoshi Nishikawa; Mika Takahashi
[13-week subchronic toxicity study of 1,1-bis(t-butylperoxy) 3,3,5-trimethyl cyclohexane in mice].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1992;(110):42-8.
1992: T Enami; Fumio Furukawa; M Mitsui; H Yoshimura; Takayoshi Imazawa; Akiyoshi Nishikawa; Mika Takahashi
[Studies on cell proliferation activities in acute toxic lesions in the liver and pancreas of hamsters treated with N-nitrosobis(2-oxopropyl)amine].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1992;(110):37-42.
1991: Mika Takahashi; T Hasegawa; Fumio Furukawa; H Okamiya; K Shinoda; K Imaida; Kazuhiro Toyoda; Y Hayashi
Enhanced lipid peroxidation in rat gastric mucosa caused by NaCl.
Carcinogenesis 1991;12(12):2201-4.
1991: Fumio Furukawa; K Imaida; H Okamiya; K Shinoda; M Sato; Takayoshi Imazawa; Y Hayashi; Mika Takahashi
Inhibitory effects of soybean trypsin inhibitor on induction of pancreatic neoplastic lesions in hamsters by N-nitrosobis(2-oxopropyl)amine.
Carcinogenesis 1991;12(11):2123-5.
1991: Mika Takahashi; K Imaida
Modification of tumor development in the gastrointestinal tract.
Progress in experimental tumor research 1991;33():58-75.
1991: K Imaida; C Furihata; M Tatematsu; C H Yoon; F Furukawa; Chikako Uneyama; Mika Takahashi; N Ito; Y Hayashi
Immunohistochemical and biochemical identification of pepsinogen isozymes in the hamster lungs: induction by polychlorinated biphenyls.
Toxicologic pathology 1991;19(3):230-6.
1991: Y Aze; Kazuhiro Toyoda; K Imaida; S Hayashi; Takayoshi Imazawa; Y Hayashi; Mika Takahashi
[Subchronic oral toxicity study of stevioside in F344 rats].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1991;(109):48-54.
1990: R Hasegawa; Fumio Furukawa; Kazuhiro Toyoda; Mika Takahashi; Y Hayashi; Masao Hirose; N Ito
Inhibitory effects of antioxidants on N-bis(2-hydroxypropyl)nitrosamine-induced lung carcinogenesis in rats.
Japanese journal of cancer research : Gann 1990;81(9):871-7.
1990: R Hasegawa; Fumio Furukawa; Kazuhiro Toyoda; H Sato; Mika Takahashi; Y Hayashi
Urothelial damage and tumor initiation by urinary metabolites of sodium o-phenylphenate in the urinary bladder of female rats.
Japanese journal of cancer research : Gann 1990;81(5):483-8.
1990: N Shimoji; K Imaida; R Hasegawa; C Matsuoka; Chikako Uneyama; Mika Takahashi; Y Hayashi
Enhancing effect of oxymetholone, an anabolic steroid, on development of liver cell foci in rats initiated with N-diethylnitrosamine.
Cancer letters 1990;49(2):165-8.
1990: M Satoh; H Okamiya; Fumio Furukawa; K Shinoda; Takayoshi Imazawa; Kazuhiro Toyoda; Mika Takahashi
[Twenty-eight day repeated dose toxicity test of dicyclopentadiene in F344 rat].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1990;(108):71-7.
1989: Mika Takahashi; H Okamiya; Fumio Furukawa; Kazuhiro Toyoda; H Sato; K Imaida; Y Hayashi
Effects of glyoxal and methylglyoxal administration on gastric carcinogenesis in Wistar rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine.
Carcinogenesis 1989;10(10):1925-7.
1989: R Hasegawa; K Yamashita; K Morimoto; Fumio Furukawa; Kazuhiro Toyoda; N Shimoji; Mika Takahashi; Y Hayashi
In situ freezing of the rat urinary bladder: DNA adduct formation in the bladder epithelium demonstrated by 32P-postlabeling assay.
Japanese journal of cancer research : Gann 1989;80(9):826-32.
1989: Takayoshi Imazawa; Kazuhiro Toyoda; K Shinoda; H Okamiya; Fumio Furukawa; K Imaida; Mika Takahashi; Y Hayashi
[Analysis of renal calcification and stone formation in rats treated with ethoxyquin using X-ray analytical scanning electron microscopy: ultrastructural observations and element analysis].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1989;(107):68-72.
1989: K Shinoda; H Okamiya; Takayoshi Imazawa; Fumio Furukawa; Kazuhiro Toyoda; H Sato; Mika Takahashi
[Application of BrdU-immunohistochemistry and lanthanum-tracer methods to the pathological evaluation of 1,3-dinitrobenzene testicular toxicity].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1989;(107):63-7.
1988: R Hasegawa; Fumio Furukawa; Kazuhiro Toyoda; J J Jang; K Yamashita; S Sato; Mika Takahashi; Y Hayashi
Study for tumor-initiating effect of acetaminophen in two-stage liver carcinogenesis of male F344 rats.
Carcinogenesis 1988;9(5):755-9.
1988: R Hasegawa; Mika Takahashi; Fumio Furukawa; Kazuhiro Toyoda; H Sato; Y Hayashi
Co-carcinogenic effect of retinyl acetate on forestomach carcinogenesis of male F344 rats induced with butylated hydroxyanisole.
Japanese journal of cancer research : Gann 1988;79(3):320-8.
1988: H Okamiya; Takayoshi Imazawa; H Sato; Fumio Furukawa; Kazuhiro Toyoda; H Onodera; Mika Takahashi; Y Hayashi
[Application and significance of X-ray analytical scanning electron microscopy in investigation of rat urinary bladder stones].
Eisei Shikenjo hōkoku. Bulletin of National Institute of Hygienic Sciences 1988;(106):82-7.
1987: H Sato; Mika Takahashi; Fumio Furukawa; Y Miyakawa; R Hasegawa; Kazuhiro Toyoda; Y Hayashi
Initiating potential of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2), butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT) and 3,3',4',5,7-pentahydroxyflavone (quercetin) in two-stage mouse skin carcinogenesis.
Cancer letters 1987;38(1-2):49-56.