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Akira Takai

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Atsushi Miyazaki; Magne O Sydnes; Minoru Isobe; Hiroshi Ohinata; Motoi Miyazu; Akira Takai
Oxidatively induced Cu for Mn exchange in protein phosphatase 1gamma: a new method for active site analysis.
Magne O Sydnes; Masaki Kuse; Masakuni Kurono; Aya Shimomura; Hiroshi Ohinata; Akira Takai; Minoru Isobe
Protein phosphatase inhibitory activity of tautomycin photoaffinity probes evaluated at femto-molar level.
Minoru Isobe; Masakuni Kurono; Katsunori Tsuboi; Akira Takai
Synthesis of [18,19,21,22-(13)C4]-labeled tautomycin as an NMR probe of protein phosphatase inhibitor.

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All Publications

2009: Atsushi Miyazaki; Magne O Sydnes; Minoru Isobe; Hiroshi Ohinata; Motoi Miyazu; Akira Takai
Oxidatively induced Cu for Mn exchange in protein phosphatase 1gamma: a new method for active site analysis.
Bioorganic & medicinal chemistry 2009;17(23):7978-86.
2008: Magne O Sydnes; Masaki Kuse; Masakuni Kurono; Aya Shimomura; Hiroshi Ohinata; Akira Takai; Minoru Isobe
Protein phosphatase inhibitory activity of tautomycin photoaffinity probes evaluated at femto-molar level.
Bioorganic & medicinal chemistry 2008;16(4):1747-55.
2007: Minoru Isobe; Masakuni Kurono; Katsunori Tsuboi; Akira Takai
Synthesis of [18,19,21,22-(13)C4]-labeled tautomycin as an NMR probe of protein phosphatase inhibitor.
Chemistry, an Asian journal 2007;2(3):377-85.
2000: Akira Takai; Katsunori Tsuboi; M Koyasu; Minoru Isobe
Effects of modification of the hydrophobic C-1-C-16 segment of tautomycin on its affinity to type-1 and type-2A protein phosphatases.
The Biochemical journal 2000;350 Pt 1():81-8.
1998: Akira Takai
[Naturally occurring toxins with specific inhibitory activity against protein serine/threonine phosphatases 1 and 2A].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1998;43(8 Suppl):1091-101.
1997: Masaharu Takemura; T Kitagawa; Shunji Izuta; J Wasa; Akira Takai; T Akiyama; Shonen Yoshida
Phosphorylated retinoblastoma protein stimulates DNA polymerase alpha.
Oncogene 1997;15(20):2483-92.
1997: Y Takai; S Awaya; Akira Takai
Activation of non-selective cation conductance by carbachol in freshly isolated bovine ciliary muscle cells.
Pflügers Archiv : European journal of physiology 1997;433(6):705-12.
1995: Akira Takai; K Sasaki; H Nagai; G Mieskes; M Isobe; K Isono; T Yasumoto
Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: method of analysis of interactions of tight-binding ligands with target protein.
The Biochemical journal 1995;306 ( Pt 3)():657-65.
1994: K Sasaki; M Murata; T Yasumoto; G Mieskes; Akira Takai
Affinity of okadaic acid to type-1 and type-2A protein phosphatases is markedly reduced by oxidation of its 27-hydroxyl group.
The Biochemical journal 1994;298 ( Pt 2)():259-62.
1992: Akira Takai; Y Ohno; T Yasumoto; G Mieskes
Estimation of the rate constants associated with the inhibitory effect of okadaic acid on type 2A protein phosphatase by time-course analysis.
The Biochemical journal 1992;287 ( Pt 1)():101-6.
1992: Akira Takai; M Murata; K Torigoe; M Isobe; G Mieskes; T Yasumoto
Inhibitory effect of okadaic acid derivatives on protein phosphatases. A study on structure-affinity relationship.
The Biochemical journal 1992;284 ( Pt 2)():539-44.
1991: T Shigetomi; T Hayashi; Minoru Ueda; T Kaneda; H Tokuno; Akira Takai; T Tomita
Effects of Ca2+ removal and of tetraethylammonium on membrane currents induced by carbachol in isolated cells from the rat parotid gland.
Pflügers Archiv : European journal of physiology 1991;419(3-4):332-7.
1991: Akira Takai; G Mieskes
Inhibitory effect of okadaic acid on the p-nitrophenyl phosphate phosphatase activity of protein phosphatases.
The Biochemical journal 1991;275 ( Pt 1)():233-9.
1989: H Kume; Akira Takai; H Tokuno; T Tomita
Regulation of Ca2+-dependent K+-channel activity in tracheal myocytes by phosphorylation.
Nature 1989;341(6238):152-4.
1989: Akira Takai; M Troschka; G Mieskes; A V Somlyo
Protein phosphatase composition in the smooth muscle of guinea-pig ileum studied with okadaic acid and inhibitor 2.
The Biochemical journal 1989;262(2):617-23.
1988: C Bialojan; Akira Takai
Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics.
The Biochemical journal 1988;256(1):283-90.
1988: S Nakayama; Y Seo; Akira Takai; T Tomita; H Watari
Phosphorous compounds studied by 31P nuclear magnetic resonance spectroscopy in the taenia of guinea-pig caecum.
The Journal of physiology 1988;402():565-78.
1988: J Hescheler; G Mieskes; J Caspar Rüegg; Akira Takai; W Trautwein
Effects of a protein phosphatase inhibitor, okadaic acid, on membrane currents of isolated guinea-pig cardiac myocytes.
Pflügers Archiv : European journal of physiology 1988;412(3):248-52.
1988: C Bialojan; J Caspar Rüegg; Akira Takai
Effects of okadaic acid on isometric tension and myosin phosphorylation of chemically skinned guinea-pig taenia coli.
The Journal of physiology 1988;398():81-95.
1987: Akira Takai; C Bialojan; M Troschka; J Caspar Rüegg
Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin.
FEBS letters 1987;217(1):81-4.