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Shinji Takai

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Shinji Takai; Kazumi Niinuma; Shizuka Aritomi; Denan Jin; Mizuo Miyazaki
Powerful vascular protection by combining cilnidipine with valsartan in stroke-prone, spontaneously hypertensive rats.
Tomohiro Fujisaka; Toshiaki Hanafusa; Masaaki Hoshiga; Junko Hotchi; Denan Jin; Shinji Takai; Yoshihiro Takeda; Nobukazu Ishizaka
Angiotensin II promotes aortic valve thickening independent of elevated blood pressure in apolipoprotein-E deficient mice.
Daisuke Yamamoto; Shigeaki Muto; Shinji Takai; Tetsu Akimoto; Ichiro Hirahara; Chiharu Ito; Eiji Kusano
Matrix metalloproteinase-2 inhibition by temocapril and its important role in peritoneal transport.

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All Publications

2013: Shinji Takai; Kazumi Niinuma; Shizuka Aritomi; Denan Jin; Mizuo Miyazaki
Powerful vascular protection by combining cilnidipine with valsartan in stroke-prone, spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2013;36(4):342-8.
2013: Tomohiro Fujisaka; Toshiaki Hanafusa; Masaaki Hoshiga; Junko Hotchi; Denan Jin; Shinji Takai; Yoshihiro Takeda; Nobukazu Ishizaka
Angiotensin II promotes aortic valve thickening independent of elevated blood pressure in apolipoprotein-E deficient mice.
Atherosclerosis 2013;226(1):82-7.
2012: Daisuke Yamamoto; Shigeaki Muto; Shinji Takai; Tetsu Akimoto; Ichiro Hirahara; Chiharu Ito; Eiji Kusano
Matrix metalloproteinase-2 inhibition by temocapril and its important role in peritoneal transport.
Clinical and experimental pharmacology & physiology 2012;39(10):864-8.
2012: Takuya Kotani; Shigeki Makino; Koji Nagai; Shinji Takai; Tohru Takeuchi; Daisuke Wakura; Shuzo Yoshida; Kenichiro Hata; Kentaro Isoda; Toshiaki Hanafusa
Serum levels of matrix metalloproteinase (MMP) 9, a risk factor for acute coronary syndrome, are reduced independently of serum MMP-3 by anti-TNF-α antibody (infliximab) therapy in patients with rheumatoid arthritis.
Journal of pharmacological sciences 2012;120(1):50-3.
2012: Denan Jin; Zhonglian Li; Yoshinori Otsuki; Hiroshi Sakonjo; Yuro Shibayama; Shinji Takai; Mizuo Miyazaki
Outside fibroblasts play a key role in the development of inner neointima after the implantation of polytetrafluoroethylene grafts.
Journal of pharmacological sciences 2012;119(2):139-49.
2012: Shinji Takai; Denan Jin; Mizuo Miyazaki
Multiple mechanisms for the action of chymase inhibitors.
Journal of pharmacological sciences 2012;118(3):311-6.
2011: Shinji Takai; Denan Jin; Takashi Shimosato; Hiroshi Sakonjo; Mizuo Miyazaki
Candesartan and amlodipine combination therapy provides powerful vascular protection in stroke-prone spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2011;34(2):245-52.
2010: Shinji Takai; Denan Jin; Hiroshi Sakonjo; Mizuo Miyazaki
Combination therapy with irbesartan and efonidipine for attenuation of proteinuria in Dahl salt-sensitive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2010;33(9):953-9.
2010: Koji Komeda; Shinji Takai; Denan Jin; Keitaro Tashiro; Michihiro Hayashi; Nobuhiko Tanigawa; Mizuo Miyazaki
Chymase inhibition attenuates tetrachloride-induced liver fibrosis in hamsters.
Hepatology research : the official journal of the Japan Society of Hepatology 2010;40(8):832-40.
2010: Daisuke Yamamoto; Shinji Takai; Ichiro Hirahara; Eiji Kusano
Captopril directly inhibits matrix metalloproteinase-2 activity in continuous ambulatory peritoneal dialysis therapy.
Clinica chimica acta; international journal of clinical chemistry 2010;411(9-10):762-4.
2010: Keitaro Tashiro; Shinji Takai; Denan Jin; Hiromi Yamamoto; Koji Komeda; Michihiro Hayashi; Kazuhiko Tanaka; Nobuhiko Tanigawa; Mizuo Miyazaki
Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet.
Hepatology research : the official journal of the Japan Society of Hepatology 2010;40(5):514-23.
2010: Tetsuya Hayashi; Shinji Takai; Chika Yamashita
Impact of the renin-angiotensin-aldosterone-system on cardiovascular and renal complications in diabetes mellitus.
Current vascular pharmacology 2010;8(2):189-97.
2010: Kazuki Kakimoto; Shinji Takai; Mitsuyuki Murano; Kumi Ishida; Yukiko Yoda; Takuya Inoue; Denan Jin; Eiji Umegaki; Kazuhide Higuchi
Significance of chymase-dependent matrix metalloproteinase-9 activation on indomethacin-induced small intestinal damages in rats.
The Journal of pharmacology and experimental therapeutics 2010;332(2):684-9.
2010: Nao Inoue; Shinji Takai; Denan Jin; Kenichi Okumura; Naoyuki Okamura; Mitsugu Kajiura; Sosuke Yoshikawa; Naohisa Kawamura; Hiroshi Tamai; Mizuo Miyazaki
Effect of angiotensin-converting enzyme inhibitor on matrix metalloproteinase-9 activity in patients with Kawasaki disease.
Clinica chimica acta; international journal of clinical chemistry 2010;411(3-4):267-9.
2010: Shinji Takai; Denan Jin; Mizuo Miyazaki
New approaches to blockade of the renin-angiotensin-aldosterone system: chymase as an important target to prevent organ damage.
Journal of pharmacological sciences 2010;113(4):301-9.
2010: Shinji Takai; Denan Jin; Mizuo Miyazaki
Chymase as an important target for preventing complications of metabolic syndrome.
Current medicinal chemistry 2010;17(28):3223-9.
2009: Shinji Takai; Denan Jin; Hironobu Ikeda; Hiroshi Sakonjo; Mizuo Miyazaki
Significance of angiotensin II receptor blockers with high affinity to angiotensin II type 1 receptors for vascular protection in rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2009;32(10):853-60.
2009: Shinji Takai; Denan Jin; Hiroshi Kawashima; Maki Kimura; Akiko Shiraishi-Tateishi; Takao Tanaka; Saki Kakutani; Kazuhiko Tanaka; Yoshinobu Kiso; Mizuo Miyazaki
Anti-atherosclerotic effects of dihomo-gamma-linolenic acid in ApoE-deficient mice.
Journal of atherosclerosis and thrombosis 2009;16(4):480-9.
2009: Shinji Takai; Denan Jin; Mariko Ohzu; Kazuhiko Tanaka; Mizuo Miyazaki
Chymase inhibition provides pancreatic islet protection in hamsters with streptozotocin-induced diabetes.
Journal of pharmacological sciences 2009;110(4):459-65.
2009: Nao Inoue; Michiko Muramatsu; Denan Jin; Shinji Takai; Tetsuya Hayashi; Hiroshi Katayama; Yasushi Kitaura; Hiroshi Tamai; Mizuo Miyazaki
Involvement of vascular angiotensin II-forming enzymes in the progression of aortic abdominal aneurysms in angiotensin II- infused ApoE-deficient mice.
Journal of atherosclerosis and thrombosis 2009;16(3):164-71.
2009: Nao Inoue; Michiko Muramatsu; Denan Jin; Shinji Takai; Tetsuya Hayashi; Hiroshi Katayama; Yasushi Kitaura; Hiroshi Tamai; Mizuo Miyazaki
Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice.
Atherosclerosis 2009;204(2):359-64.
2009: Nobuyuki Amano; Shinji Takai; Denan Jin; Koichi Ueda; Mizuo Miyazaki
Possible roles of mast cell-derived chymase for skin rejuvenation.
Lasers in medical science 2009;24(2):223-9.
2009: Denan Jin; Shinji Takai; Tetsuya Sugiyama; Tetsuya Hayashi; Masanori Fukumoto; Hidehiro Oku; Yasushi Kitaura; Tsunehiko Ikeda; Mizuo Miyazaki
Long-term angiotensin II blockade may improve not only hyperglycemia but also age-associated cardiac fibrosis.
Journal of pharmacological sciences 2009;109(2):275-84.
2009: Daisuke Yamamoto; Shinji Takai
Pharmacological implications of MMP-9 inhibition by ACE inhibitors.
Current medicinal chemistry 2009;16(11):1349-54.
2008: Masanori Fukumoto; Shinji Takai; Eisuke Ishizaki; Tetsuya Sugiyama; Hidehiro Oku; Denan Jin; Masato Sakaguchi; Hiroshi Sakonjo; Tsunehiko Ikeda; Mizuo Miyazaki
Involvement of angiotensin II-dependent vascular endothelial growth factor gene expression via NADPH oxidase in the retina in a type 2 diabetic rat model.
Current eye research 2008;33(10):885-91.
2008: Daisuke Yamamoto; Shinji Takai; Mizuo Miyazaki
Inhibitory profiles of captopril on matrix metalloproteinase-9 activity.
European journal of pharmacology 2008;588(2-3):277-9.
2008: Koji Komeda; Denan Jin; Shinji Takai; Michihiro Hayashi; Atsushi Takeshita; Yuro Shibayama; Nobuhiko Tanigawa; Mizuo Miyazaki
Significance of chymase-dependent angiotensin II formation in the progression of human liver fibrosis.
Hepatology research : the official journal of the Japan Society of Hepatology 2008;38(5):501-10.
2008: Kumi Ishida; Shinji Takai; Mitsuyuki Murano; Takashi Nishikawa; Takuya Inoue; Naoko Murano; Nao Inoue; Denan Jin; Eiji Umegaki; Kazuhide Higuchi; Mizuo Miyazaki
Role of chymase-dependent matrix metalloproteinase-9 activation in mice with dextran sodium sulfate-induced colitis.
The Journal of pharmacology and experimental therapeutics 2008;324(2):422-6.
2008: Keiichi Furubayashi; Shinji Takai; Denan Jin; Mizuo Miyazaki; Takahiro Katsumata; Sachiko Inagaki; Maki Kimura; Kazuhiko Tanaka; Masayoshi Nishimoto; Hitoshi Fukumoto
Chymase activates promatrix metalloproteinase-9 in human abdominal aortic aneurysm.
Clinica chimica acta; international journal of clinical chemistry 2008;388(1-2):214-6.
2007: Shinji Takai; Denan Jin; Maki Kimura; Kazuyoshi Kirimura; Hiroshi Sakonjo; Kazuhiko Tanaka; Mizuo Miyazaki
Inhibition of vascular angiotensin-converting enzyme by telmisartan via the peroxisome proliferator-activated receptor gamma agonistic property in rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(12):1231-7.
2007: Shinji Takai; Denan Jin; Sachiko Inagaki; Daisuke Yamamoto; Kazuhiko Tanaka; Mizuo Miyazaki
Significance of matrix metalloproteinase-9 in cardiac dysfunction during the very acute phase after myocardial infarction in hamsters.
European journal of pharmacology 2007;572(1):57-60.
2007: Denan Jin; Haruhiko Ueda; Shinji Takai; Michiko Muramatsu; Keiichi Furubayashi; Toshihiko Ibaraki; Kanta Kishi; Yoji Katsuoka; Mizuo Miyazaki
Roles of chymase in stenosis occurring after polytetrafluoroethylene graft implantations.
Life sciences 2007;81(16):1291-300.
2007: Shinji Takai; Daisuke Yamamoto; Denan Jin; Sachiko Inagaki; Katsuhiro Yoshikawa; Kazuhiko Tanaka; Mizuo Miyazaki
Inhibition of matrix metalloproteinase-9 activity by lisinopril after myocardial infarction in hamsters.
European journal of pharmacology 2007;568(1-3):231-3.
2007: Keiichi Furubayashi; Shinji Takai; Denan Jin; Michiko Muramatsu; Toshihiko Ibaraki; Masayoshi Nishimoto; Hitoshi Fukumoto; Takahiro Katsumata; Mizuo Miyazaki
The significance of chymase in the progression of abdominal aortic aneurysms in dogs.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(4):349-57.
2007: Kanta Kishi; Michiko Muramatsu; Denan Jin; Keiichi Furubayashi; Shinji Takai; Hiroshi Tamai; Mizuo Miyazaki
The effects of chymase on matrix metalloproteinase-2 activation in neointimal hyperplasia after balloon injury in dogs.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(1):77-83.
2006: Mizuo Miyazaki; Shinji Takai; Denan Jin; Michiko Muramatsu
Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models.
Pharmacology & therapeutics 2006;112(3):668-76.
2006: Shinji Takai; Mizuo Miyazaki
[Anti-atherosclerotic effect].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():518-23.
2006: Shinji Takai; Mizuo Miyazaki
[Tumor suppressive effect].
Nihon rinsho. Japanese journal of clinical medicine 2006;64 Suppl 5():512-7.
2006: Kanta Kishi; Denan Jin; Shinji Takai; Michiko Muramatsu; Hiroshi Katayama; Hiroshi Tamai; Mizuo Miyazaki
Role of chymase-dependent angiotensin II formation in monocrotaline-induced pulmonary hypertensive rats.
Pediatric research 2006;60(1):77-82.
2006: Shinji Takai; Mizuo Miyazaki
Effect of olmesartan medoxomil on atherosclerosis: clinical implications of the emerging evidence.
American journal of cardiovascular drugs : drugs, devices, and other interventions 2006;6(6):363-6.
2006: Mizuo Miyazaki; Shinji Takai
Tissue angiotensin II generating system by angiotensin-converting enzyme and chymase.
Journal of pharmacological sciences 2006;100(5):391-7.
2005: Shinji Takai; Denan Jin; Michiko Muramatsu; Kazuyoshi Kirimura; Hiroshi Sakonjo; Mizuo Miyazaki
Eplerenone inhibits atherosclerosis in nonhuman primates.
Hypertension 2005;46(5):1135-9.
2005: Shinji Takai; Denan Jin; Masato Sakaguchi; Michiko Muramatsu; Mizuo Miyazaki
The regressive effect of an angiotensin II receptor blocker on formed fatty streaks in monkeys fed a high-cholesterol diet.
Journal of hypertension 2005;23(10):1879-86.
2005: Toshihiko Ibaraki; Michiko Muramatsu; Shinji Takai; Denan Jin; Hiroshi Maruyama; Tatsuhiko Orino; Takahiro Katsumata; Mizuo Miyazaki
The relationship of tryptase- and chymase-positive mast cells to angiogenesis in stage I non-small cell lung cancer.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2005;28(4):617-21.
2005: Shinji Takai; Kazuyoshi Kirimura; Denan Jin; Michiko Muramatsu; Katsuhiro Yoshikawa; Yoshiki Mino; Mizuo Miyazaki
Significance of angiotensin II receptor blocker lipophilicities and their protective effect against vascular remodeling.
Hypertension research : official journal of the Japanese Society of Hypertension 2005;28(7):593-600.
2005: Kazuyoshi Kirimura; Shinji Takai; Denan Jin; Michiko Muramatsu; Kanta Kishi; Katsuhiro Yoshikawa; Mika Nakabayashi; Yoshiki Mino; Mizuo Miyazaki
Role of chymase-dependent angiotensin II formation in regulating blood pressure in spontaneously hypertensive rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2005;28(5):457-64.
2005: Denan Jin; Haruhiko Ueda; Shinji Takai; Yukiko Okamoto; Michiko Muramatsu; Masato Sakaguchi; Nobuhisa Shibahara; Yoji Katsuoka; Mizuo Miyazaki
Effect of chymase inhibition on the arteriovenous fistula stenosis in dogs.
Journal of the American Society of Nephrology : JASN 2005;16(4):1024-34.
2004: Shinji Takai; Denan Jin; Michiko Muramatsu; Yukiko Okamoto; Mizuo Miyazaki
Therapeutic applications of chymase inhibitors in cardiovascular diseases and fibrosis.
European journal of pharmacology 2004;501(1-3):1-8.
2004: Shinji Takai; Denan Jin; Michiko Muramatsu; Mizuo Miyazaki
Chymase as a novel target for the prevention of vascular diseases.
Trends in pharmacological sciences 2004;25(10):518-22.
2004: Denan Jin; Shinji Takai; Yukiko Okamoto; Michiko Muramatsu; Mizuo Miyazaki
Chymase-derived angiotensin II and arrhythmias after myocardial infarction.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2004;124(2):77-82.
2004: Shinji Takai; Denan Jin; Masato Sakaguchi; Michiko Muramatsu; Kenji Ishii; Kazuyoshi Kirimura; Hiroshi Sakonjo; Mizuo Miyazaki
Comparative effects of candesartan and amlodipine in a monkey atherosclerotic model.
Hypertension research : official journal of the Japanese Society of Hypertension 2004;27(7):517-22.
2004: Midori Maruichi; Shinji Takai; Tetsuya Sugiyama; Mari Ueki; Hidehiro Oku; Masato Sakaguchi; Yukiko Okamoto; Michiko Muramatsu; Tsunehiko Ikeda; Mizuo Miyazaki
Role of chymase on growth of cultured canine Tenon's capsule fibroblasts and scarring in a canine conjunctival flap model.
Experimental eye research 2004;79(1):111-8.
2004: Masato Sakaguchi; Shinji Takai; Denan Jin; Yukiko Okamoto; Michiko Muramatsu; Shokei Kim; Mizuo Miyazaki
A specific chymase inhibitor, NK3201, suppresses bleomycin-induced pulmonary fibrosis in hamsters.
European journal of pharmacology 2004;493(1-3):173-6.
2004: Koutaro Tsunemi; Shinji Takai; Masayoshi Nishimoto; Denan Jin; Masato Sakaguchi; Michiko Muramatsu; Atsushi Yuda; Shinjiro Sasaki; Mizuo Miyazaki
A specific chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[3,4-dioxo-1-phenyl-7-(2-pyridyloxy)]-2-heptyl]acetamide (NK3201), suppresses development of abdominal aortic aneurysm in hamsters.
The Journal of pharmacology and experimental therapeutics 2004;309(3):879-83.
2004: Denan Jin; Shinji Takai; Masato Sakaguchi; Yukiko Okamoto; Michiko Muramatsu; Mizuo Miyazaki
An antiarrhythmic effect of a chymase inhibitor after myocardial infarction.
The Journal of pharmacology and experimental therapeutics 2004;309(2):490-7.
2004: Shinji Takai; Denan Jin; Masato Sakaguchi; Mizuo Miyazaki
A single treatment with a specific chymase inhibitor, TY-51184, prevents vascular proliferation in canine grafted veins.
Journal of pharmacological sciences 2004;94(4):443-8.
2004: Shinji Takai; Denan Jin; Masato Sakaguchi; Mizuo Miyazaki
Significant target organs for hypertension and cardiac hypertrophy by angiotensin-converting enzyme inhibitors.
Hypertension research : official journal of the Japanese Society of Hypertension 2004;27(3):213-9.
2004: Yukiko Okamoto; Shinji Takai; Mizuo Miyazaki
Significance of chymase inhibition for prevention of adhesion formation.
European journal of pharmacology 2004;484(2-3):357-9.
2004: Yukiko Okamoto; Shinji Takai; Mizuo Miyazaki
Effect of chymase-dependent transforming growth factor beta on peritoneal adhesion formation in a rat model.
Surgery today 2004;34(10):865-7.
2003: Denan Jin; Shinji Takai; Mayumi Yamada; Masato Sakaguchi; Keiichi Kamoshita; Koichi Ishida; Yoshikazu Sukenaga; Mizuo Miyazaki
Impact of chymase inhibitor on cardiac function and survival after myocardial infarction.
Cardiovascular research 2003;60(2):413-20.
2003: Shinji Takai
[Role of chymase in vascular diseases and the efficacy of chymase inhibitor].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;122(2):111-20.
2003: Shinji Takai; Mizuo Miyazaki
A novel therapeutic strategy against vascular disorders with chymase inhibitor.
Current vascular pharmacology 2003;1(2):217-24.
2003: Shinji Takai; Denan Jin; Masato Sakaguchi; Satoru Katayama; Michiko Muramatsu; Minoru Sakaguchi; Eiko Matsumura; Shokei Kim; Mizuo Miyazaki
A novel chymase inhibitor, 4-[1-([bis-(4-methyl-phenyl)-methyl]-carbamoyl)3-(2-ethoxy-benzyl)-4-oxo-azetidine-2-yloxy]-benzoic acid (BCEAB), suppressed cardiac fibrosis in cardiomyopathic hamsters.
The Journal of pharmacology and experimental therapeutics 2003;305(1):17-23.
2003: Michiko Muramatsu; Shinji Takai; Mizuo Miyazaki
[Detections of matrix metalloproteinases activities and localization by film in situ zymography (FIZ)].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2003;121(2):113-8.
2003: Shinji Takai; Shokei Kim; Hiroshi Sakonjo; Mizuo Miyazaki
Mechanisms of angiotensin II type 1 receptor blocker for anti-atherosclerotic effect in monkeys fed a high-cholesterol diet.
Journal of hypertension 2003;21(2):361-9.
2003: Shinji Takai; Hiroshi Sakonjo; Kohzo Fukuda; Denan Jin; Masato Sakaguchi; Keiichi Kamoshita; Koichi Ishida; Yoshikazu Sukenaga; Mizuo Miyazaki
A novel chymase inhibitor, 2-(5-formylamino-6-oxo-2-phenyl-1,6-dihydropyrimidine-1-yl)-N-[[,4-dioxo-1-phenyl-7-(2-pyridyloxy)]2-heptyl]acetamide (NK3201), suppressed intimal hyperplasia after balloon injury.
The Journal of pharmacology and experimental therapeutics 2003;304(2):841-4.
2003: Shinji Takai; Mizuo Miyazaki
Application of a chymase inhibitor, NK3201, for prevention of vascular proliferation.
Cardiovascular drug reviews 2003;21(3):185-98.
2002: Shinji Takai; Mizuo Miyazaki
Effect of chymase inhibitor on vascular proliferation.
Japanese journal of pharmacology 2002;90(3):223-7.
2002: Yoshikazu Sukenaga; Keiichi Kamoshita; Shinji Takai; Mizuo Miyazaki
Development of the chymase inhibitor as an anti-tissue-remodeling drug: myocardial infarction and some other possibilities.
Japanese journal of pharmacology 2002;90(3):218-22.
2002: Koutaro Tsunemi; Shinji Takai; Masayoshi Nishimoto; Atsushi Yuda; Shigeto Hasegawa; Yoshihide Sawada; Hitoshi Fukumoto; Shinjiro Sasaki; Mizuo Miyazaki
Possible roles of angiotensin II-forming enzymes, angiotensin converting enzyme and chymase-like enzyme, in the human aneurysmal aorta.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(6):817-22.
2002: Yukiko Okamoto; Shinji Takai; Mizuo Miyazaki
Chymase inhibitor, BCEAB, suppressed peritoneal adhesion formation in hamster.
The Journal of surgical research 2002;107(2):219-22.
2002: Mizuo Miyazaki; Shinji Takai
[Involvement of angiotensin II in development of atherosclerosis].
Nihon rinsho. Japanese journal of clinical medicine 2002;60(10):1904-10.
2002: Michiko Muramatsu; Mayumi Yamada; Shinji Takai; Mizuo Miyazaki
Suppression of basic fibroblast growth factor-induced angiogenesis by a specific chymase inhibitor, BCEAB, through the chymase-angiotensin-dependent pathway in hamster sponge granulomas.
British journal of pharmacology 2002;137(4):554-60.
2002: Masayoshi Nishimoto; Shinji Takai; Hitoshi Fukumoto; Koutaro Tsunemi; Atsushi Yuda; Yoshihide Sawada; Mayumi Yamada; Denan Jin; Masato Sakaguchi; Yasuhisa Nishimoto; Shinjiro Sasaki; Mizuo Miyazaki
Increased local angiotensin II formation in aneurysmal aorta.
Life sciences 2002;71(18):2195-205.
2002: Yukiko Okamoto; Shinji Takai; Mizuo Miyazaki
Oral administration of a novel chymase inhibitor, NK3201, prevents peritoneal adhesion formation in hamsters.
Japanese journal of pharmacology 2002;90(1):94-6.
2002: Koutaro Tsunemi; Shinji Takai; Masayoshi Nishimoto; Atsushi Yuda; Denan Jin; Masato Sakaguchi; Yoshihide Sawada; Kunio Asada; Keiichiro Kondo; Shinjiro Sasaki; Mizuo Miyazaki
Lengthy suppression of vascular proliferation by a chymase inhibitor in dog grafted veins.
The Journal of thoracic and cardiovascular surgery 2002;124(3):621-5.
2002: Ken Okamoto; Shinji Takai; Shinjiro Sasaki; Mizuo Miyazaki
Trandolapril reduces infarction area after middle cerebral artery occlusion in rats.
Hypertension research : official journal of the Japanese Society of Hypertension 2002;25(4):583-8.
2002: Denan Jin; Shinji Takai; Mayumi Yamada; Masato Sakaguchi; Mizuo Miyazaki
Beneficial effects of cardiac chymase inhibition during the acute phase of myocardial infarction.
Life sciences 2002;71(4):437-46.
2002: Yukiko Okamoto; Shinji Takai; Mayumi Yamada; Mizuo Miyazaki
Chymase inhibitors may prevent postoperative adhesion formation.
Fertility and sterility 2002;77(5):1044-8.
2002: Mizuo Miyazaki; Shinji Takai
Anti-atherosclerotic efficacy of olmesartan.
Journal of human hypertension 2002;16 Suppl 2():S7-12.
2002: Kenichi Okumura; Denan Jin; Shinji Takai; Mizuo Miyazaki
Beneficial effects of angiotensin-converting enzyme inhibition in adriamycin-induced cardiomyopathy in hamsters.
Japanese journal of pharmacology 2002;88(2):183-8.
2002: Yukiko Okamoto; Shinji Takai; Mizuo Miyazaki
Chymase inhibitor suppresses adhesion formation in a hamster experimental model.
European journal of pharmacology 2002;435(2-3):265-7.
2001: Masayoshi Nishimoto; Shinji Takai; Shokei Kim; Denan Jin; Atsushi Yuda; Masato Sakaguchi; Mayumi Yamada; Yoshihide Sawada; Keiichiro Kondo; Kunio Asada; Hiroshi Iwao; Shinjiro Sasaki; Mizuo Miyazaki
Significance of chymase-dependent angiotensin II-forming pathway in the development of vascular proliferation.
Circulation 2001;104(11):1274-9.
2001: Shinji Takai; Hiroshi Sakonjo; Mizuo Miyazaki
Beneficial effect of trandolapril on the lifespan of a severe hypertensive model.
Hypertension research : official journal of the Japanese Society of Hypertension 2001;24(5):559-64.
2001: Shinji Takai; Denan Jin; Masayoshi Nishimoto; Atsushi Yuda; Masato Sakaguchi; Keiichi Kamoshita; Koichi Ishida; Yoshikazu Sukenaga; Shinjiro Sasaki; Mizuo Miyazaki
Oral administration of a specific chymase inhibitor, NK3201, inhibits vascular proliferation in grafted vein.
Life sciences 2001;69(15):1725-32.
2001: Denan Jin; Shinji Takai; Mayumi Yamada; Masato Sakaguchi; Y Yao; Mizuo Miyazaki
Possible roles of cardiac chymase after myocardial infarction in hamster hearts.
Japanese journal of pharmacology 2001;86(2):203-14.
2001: Shinji Takai; Denan Jin; Masato Sakaguchi; Kazuyoshi Kirimura; Mizuo Miyazaki
An orally active chymase inhibitor, BCEAB, suppresses heart chymase activity in the hamster.
Japanese journal of pharmacology 2001;86(1):124-6.
2001: Mizuo Miyazaki; Shinji Takai
Local angiotensin II-generating system in vascular tissues: the roles of chymase.
Hypertension research : official journal of the Japanese Society of Hypertension 2001;24(3):189-93.
2001: Shinji Takai; Denan Jin; Kazuyoshi Kirimura; Y Fujimoto; Mizuo Miyazaki
12-Hydroxyeicosatetraenoic acid potentiates angiotensin II-induced pressor response in rats.
European journal of pharmacology 2001;418(1-2):R1-2.
2001: Masayoshi Nishimoto; Shinji Takai; Yoshihide Sawada; Atsushi Yuda; Keiichiro Kondo; Mayumi Yamada; Denan Jin; Masato Sakaguchi; Kunio Asada; Shinjiro Sasaki; Mizuo Miyazaki
Chymase-dependent angiotensin II formation in the saphenous vein versus the internal thoracic artery.
The Journal of thoracic and cardiovascular surgery 2001;121(4):729-34.
2001: Mayumi Yamada; Makiko Ueda; Takahiko Naruko; S Tanabe; Y S Han; Yoshihiro Ikura; Masayuki Ogami; Shinji Takai; Mizuo Miyazaki
Mast cell chymase expression and mast cell phenotypes in human rejected kidneys.
Kidney international 2001;59(4):1374-81.
2001: Shinji Takai; Masato Sakaguchi; Denan Jin; M Yamada; K Kirimura; Mizuo Miyazaki
Different angiotensin II-forming pathways in human and rat vascular tissues.
Clinica chimica acta; international journal of clinical chemistry 2001;305(1-2):191-5.
2001: K Takao; Shinji Takai; T Ishihara; S Mita; Mizuo Miyazaki
Isolation of chymase complexed with physiological inhibitor similar to secretory leukocyte protease inhibitor (SLPI) from hamster cheek pouch tissues.
Biochimica et biophysica acta 2001;1545(1-2):146-52.
2001: Koutaro Tsunemi; Masayoshi Nishimoto; Shinji Takai; Atsushi Yuda; Yasuhisa Nishimoto; Shigeto Hasegawa; Kunio Asada; Yoshihide Sawada; Keiichiro Kondo; Hitoshi Fukumoto; Mizuo Miyazaki; Shinjiro Sasaki
[Role of angiotensin II-forming pathway in ruptured aortic aneurysms].
Nihon Geka Gakkai zasshi 2001;102(2):243.
2001: Shinji Takai; Denan Jin; Masayoshi Nishimoto; Masato Sakaguchi; Kazuyoshi Kirimura; Atsushi Yuda; Mizuo Miyazaki
Cilostazol suppresses intimal formation in dog grafted veins with reduction of angiotensin II-forming enzymes.
European journal of pharmacology 2001;411(3):301-4.
2000: Denan Jin; Shinji Takai; Mayumi Yamada; Masato Sakaguchi; Mizuo Miyazaki
The functional ratio of chymase and angiotensin converting enzyme in angiotensin I-induced vascular contraction in monkeys, dogs and rats.
Japanese journal of pharmacology 2000;84(4):449-54.
2000: Masato Sakaguchi; Shinji Takai; Denan Jin; Mayumi Yamada; Mizuo Miyazaki
Characteristics of monkey tryptase purified from cheek pouch vascular tissues.
Japanese journal of pharmacology 2000;84(4):375-80.
2000: Atsushi Yuda; Shinji Takai; Denan Jin; Yoshihide Sawada; Masayoshi Nishimoto; N Matsuyama; Kunio Asada; Keiichiro Kondo; Shinjiro Sasaki; Mizuo Miyazaki
Angiotensin II receptor antagonist, L-158,809, prevents intimal hyperplasia in dog grafted veins.
Life sciences 2000;68(1):41-8.
2000: Shinji Takai; Masato Sakaguchi; Denan Jin; Mizuo Miyazaki
A new method for simultaneous measurements of mast cell proteases in human vascular tissue.
Clinical and experimental pharmacology & physiology 2000;27(9):700-4.
2000: Shinji Takai; Atsushi Yuda; Denan Jin; Masayoshi Nishimoto; M Sakagichi; Shinjiro Sasaki; Mizuo Miyazaki
Inhibition of chymase reduces vascular proliferation in dog grafted veins.
FEBS letters 2000;467(2-3):141-4.
2000: Shinji Takai; S Sumi; M Aoike; Masato Sakaguchi; Y Itoh; Denan Jin; Eiko Matsumura; Mizuo Miyazaki
Characterization of recombinant human chymase expressed in Escherichia coli.
Japanese journal of pharmacology 2000;82(2):144-9.
1999: K Takao; Shinji Takai; T Ishihara; S Mita; Mizuo Miyazaki
Inhibition of human chymase by suramin.
Japanese journal of pharmacology 1999;81(4):404-7.
1999: Shinji Takai; Denan Jin; Mizuo Miyazaki
[Pathophysiological roles of chymase and effects of chymase inhibitor].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 1999;114 Suppl 1():41P-47P.
1999: Mizuo Miyazaki; Hiroshi Sakonjo; Shinji Takai
Anti-atherosclerotic effects of an angiotensin converting enzyme inhibitor and an angiotensin II antagonist in Cynomolgus monkeys fed a high-cholesterol diet.
British journal of pharmacology 1999;128(3):523-9.
1999: Shinji Takai; Denan Jin; Masato Sakaguchi; Mizuo Miyazaki
Chymase-dependent angiotensin II formation in human vascular tissue.
Circulation 1999;100(6):654-8.
1999: Shinji Takai; Denan Jin; Kazuyoshi Kirimura; J Ikeda; Masato Sakaguchi; K Baba; T Fujita; Mizuo Miyazaki
Effects of a lipoxygenase inhibitor, panaxynol, on vascular contraction induced by angiotensin II.
Japanese journal of pharmacology 1999;80(1):89-92.
1999: Shinji Takai; Mizuo Miyazaki
[Role of angiotensin II-forming enzymes, angiotensin-converting enzyme and chymase].
Nihon rinsho. Japanese journal of clinical medicine 1999;57(5):1078-83.
1999: Mizuo Miyazaki; Naotaka Shiota; Hiroshi Sakonjo; Shinji Takai
Angiotensin II type 1 receptor antagonist, TCV-116, prevents neointima formation in injured arteries in the dog.
Japanese journal of pharmacology 1999;79(4):455-60.
1999: K Takao; Shinji Takai; Naotaka Shiota; K Song; K Nishimura; T Ishihara; Mizuo Miyazaki
Lack of effect of carbohydrate depletion on some properties of human mast cell chymase.
Biochimica et biophysica acta 1999;1427(1):74-81.
1999: Naotaka Shiota; Hideki Okunishi; Shinji Takai; I Mikoshiba; Hiroshi Sakonjo; N Shibata; Mizuo Miyazaki
Tranilast suppresses vascular chymase expression and neointima formation in balloon-injured dog carotid artery.
Circulation 1999;99(8):1084-90.
1999: Mizuo Miyazaki; Shinji Takai
Antiatherosclerotic effect of alacepril, an angiotensin-converting enzyme inhibitor, in monkeys fed a high-cholesterol diet.
Hypertension research : official journal of the Japanese Society of Hypertension 1999;22(1):49-54.
1999: Shinji Takai; Denan Jin; Masato Sakaguchi; Kazuyoshi Kirimura; J Ikeda; K Baba; T Fujita; Mizuo Miyazaki
Effects of a new 12-lipoxygenase inhibitor, daphnodorin A, on angiotensin II-induced vascular contraction in hamster.
Prostaglandins, leukotrienes, and essential fatty acids 1999;60(2):135-8.
1999: Kai Song; Hironori Kanehara; Shinji Takai; Naotaka Shiota; T Wada; Y Inada; Mizuo Miyazaki
Inhibition of the angiotensin II Type 1 receptor by TCV-116: quantitation by in vitro autoradiography.
Japanese journal of pharmacology 1999;79(2):131-9.
1999: Shinji Takai; Masato Sakaguchi; Denan Jin; K Baba; Mizuo Miyazaki
Effects of daphnodorin A, daphnodorin B and daphnodorin C on human chymase-dependent angiotensin II formation.
Life sciences 1999;64(21):1889-96.
1999: Mizuo Miyazaki; T Wada; Naotaka Shiota; Shinji Takai
Effect of an angiotensin II receptor antagonist, candesartan cilexetil, on canine intima hyperplasia after balloon injury.
Journal of human hypertension 1999;13 Suppl 1():S21-5; discussion S33-4.
1998: Denan Jin; Shinji Takai; Naotaka Shiota; Mizuo Miyazaki
Tranilast, an anti-allergic drug, possesses antagonistic potency to angiotensin II.
European journal of pharmacology 1998;361(2-3):199-205.
1998: Shinji Takai; Naotaka Shiota; Denan Jin; Mizuo Miyazaki
Functional role of chymase in angiotensin II formation in human vascular tissue.
Journal of cardiovascular pharmacology 1998;32(5):826-33.
1998: Shinji Takai; Naotaka Shiota; Denan Jin; Mizuo Miyazaki
Chymase processes big-endothelin-2 to endothelin-2-(1-31) that induces contractile responses in the isolated monkey trachea.
European journal of pharmacology 1998;358(3):229-33.
1998: Shinji Takai; Denan Jin; K Hara; H Takami; T Fujita; Mizuo Miyazaki
12-Hydroxyeicosatetraenoic acid directly potentiates angiotensin II-induced vascular contraction.
European journal of pharmacology 1998;358(2):161-4.
1998: Naotaka Shiota; Akiyoshi Fukamizu; Hideki Okunishi; Shinji Takai; K Murakami; Mizuo Miyazaki
Cloning of the gene and cDNA for hamster chymase 2, and expression of chymase 1, chymase 2 and angiotensin-converting enzyme in the terminal stage of cardiomyopathic hearts.
The Biochemical journal 1998;333 ( Pt 2)():417-24.
1998: Denan Jin; Shinji Takai; Naotaka Shiota; Mizuo Miyazaki
Roles of vascular angiotensin converting enzyme and chymase in two-kidney, one clip hypertensive hamsters.
Journal of hypertension 1998;16(5):657-64.
1998: K Song; Naotaka Shiota; Shinji Takai; H Takashima; H Iwasaki; Shokei Kim; Mizuo Miyazaki
Induction of angiotensin converting enzyme and angiotensin II receptors in the atherosclerotic aorta of high-cholesterol fed Cynomolgus monkeys.
Atherosclerosis 1998;138(1):171-82.
1997: Denan Jin; Kai Song; Y Oka; Shinji Takai; Naotaka Shiota; Mizuo Miyazaki
Pharmacological profiles of a novel non-peptide angiotensin II type I receptor antagonist HR720 in vitro and in vivo.
Japanese journal of pharmacology 1997;75(3):259-66.
1997: Shinji Takai; Naotaka Shiota; Masato Sakaguchi; H Muraguchi; Eiko Matsumura; Mizuo Miyazaki
Characterization of chymase from human vascular tissues.
Clinica chimica acta; international journal of clinical chemistry 1997;265(1):13-20.
1997: Shinji Takai; Naotaka Shiota; S Kobayashi; Eiko Matsumura; Mizuo Miyazaki
Induction of chymase that forms angiotensin II in the monkey atherosclerotic aorta.
FEBS letters 1997;412(1):86-90.
1997: Naotaka Shiota; Denan Jin; Shinji Takai; T Kawamura; M Koyama; N Nakamura; Mizuo Miyazaki
Chymase is activated in the hamster heart following ventricular fibrosis during the chronic stage of hypertension.
FEBS letters 1997;406(3):301-4.
1997: Naotaka Shiota; Akiyoshi Fukamizu; Shinji Takai; Hideki Okunishi; K Murakami; Mizuo Miyazaki
Activation of angiotensin II-forming chymase in the cardiomyopathic hamster heart.
Journal of hypertension 1997;15(4):431-40.
1996: Shinji Takai; Kai Song; T Tanaka; Hideki Okunishi; Mizuo Miyazaki
Antinociceptive effects of angiotensin-converting enzyme inhibitors and an angiotensin II receptor antagonist in mice.
Life sciences 1996;59(21):PL331-6.
1996: Shinji Takai; Naotaka Shiota; D Yamamoto; Hideki Okunishi; Mizuo Miyazaki
Purification and characterization of angiotensin II-generating chymase from hamster cheek pouch.
Life sciences 1996;58(7):591-7.
1994: Kai Song; Mizuo Miyazaki; Hideki Okunishi; K Ishii; Shinji Takai; Naotaka Shiota; S Kim; Frederick Mendelsohn
Localization and quantitation of active renin in monkey kidney by radioinhibitor binding and in vitro autoradiography.
American journal of hypertension 1994;7(6):529-35.