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Shinji Takai
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Research Profile (preview)
Phenomena
Anatomy
Living Beings
Chemicals & Drugs
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Network (preview)
41
Kozawa, Osamu
31
Tokuda, Haruhiko
30
Matsushima-Nishiwaki, Rie
24
Hanai, Yoshiteru
12
Kato, Kanefusa
9
Harada, Atsushi
9
Yasuda, Eisuke
8
Ohta, Toshiki
8
Akamatsu, Shigeru
8
Moriwaki, Hisataka
7
Nagaki, Masahito
7
Kimura, Kiminori
6
Ogura, Shinji
5
Noda, Takahiro
5
Tanabe, Kumiko
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Publications
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Geonetwork of Shinji Takai (preview)
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All Publications
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2009: Yamaguchi Shinobu; Tanabe Kumiko; Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Iida Hiroki; Kozawa Osamu; Dohi Shuji
Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells.
Neurochemistry international 2009;55(6):438-45.
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2009: Doi Tomoaki; Adachi Seiji; Takai Shinji; Matsushima-Nishiwaki Rie; Kato Hisaaki; Enomoto Yukiko; Minamitani Chiho; Otsuka Takanobu; Tokuda Haruhiko; Akamatsu Shigeru; Iwama Toru; Kozawa Osamu; Ogura Shinji
Antithrombin III suppresses ADP-induced platelet granule secretion: inhibition of HSP27 phosphorylation.
Archives of biochemistry and biophysics 2009;489(1-2):62-7.
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2009: Hanai Yoshiteru; Adachi Seiji; Yasuda Ichiro; Takai Shinji; Matsushima-Nishiwaki Rie; Kato Hisaaki; Enomoto Yukiko; Akamatsu Shigeru; Sakakibara Seiko; Ogura Shinji; Iwama Toru; Kozawa Osamu; Tokuda Haruhiko
Collagen-induced p38 MAP kinase activation is a biomarker of platelet hyper-aggregation in patients with diabetes mellitus.
Life sciences 2009;85(9-10):386-94.
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2009: Natsume Hideo; Adachi Seiji; Takai Shinji; Tokuda Haruhiko; Matsushima-Nishiwaki Rie; Minamitani Chiho; Yamauchi Junichi; Kato Kanefusa; Mizutani Jun; Kozawa Osamu; Otsuka Takanobu
(-)-Epigallocatechin gallate attenuates the induction of HSP27 stimulated by sphingosine 1-phosphate via suppression of phosphatidylinositol 3-kinase/Akt pathway in osteoblasts.
International journal of molecular medicine 2009;24(2):197-203.
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2009: Minamitani Chiho; Otsuka Takanobu; Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Hanai Yoshiteru; Mizutani Jun; Tokuda Haruhiko; Kozawa Osamu
Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
International journal of molecular medicine 2009;24(1):77-82.
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2009: Yamauchi Junichi; Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Minamitani Chiho; Natsume Hideo; Mizutani Jun; Otsuka Takanobu; Takeda Jun; Harada Atsushi; Kozawa Osamu; Tokuda Haruhiko
Tacrolimus but not cyclosporine A enhances FGF-2-induced VEGF release in osteoblasts.
International journal of molecular medicine 2009;23(2):267-72.
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2008: Minamitani Chiho; Otsuka Takanobu; Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Hanai Yoshiteru; Mizutani Jun; Tokuda Haruhiko; Kozawa Osamu
Involvement of Rho-kinase in prostaglandin F2alpha-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts.
Molecular and cellular endocrinology 2008;291(1-2):27-32.
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2008: Tokuda Haruhiko; Takai Shinji; Matsushima-Nishiwaki Rie; Hanai Yoshiteru; Adachi Seiji; Minamitani Chiho; Mizutani Jun; Otsuka Takanobu; Kozawa Osamu
Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts.
Prostaglandins, leukotrienes, and essential fatty acids 2008;79(1-2):41-6.
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2008: Matsushima-Nishiwaki Rie; Takai Shinji; Adachi Seiji; Minamitani Chiho; Yasuda Eisuke; Noda Takahiro; Kato Kanefusa; Toyoda Hidenori; Kaneoka Yuji; Yamaguchi Akihiro; Kumada Takashi; Kozawa Osamu
Phosphorylated heat shock protein 27 represses growth of hepatocellular carcinoma via inhibition of extracellular signal-regulated kinase.
The Journal of biological chemistry 2008;283(27):18852-60.
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2008: Kato Hisaaki; Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Minamitani Chiho; Otsuka Takanobu; Tokuda Haruhiko; Akamatsu Shigeru; Doi Tomoaki; Ogura Shinji; Kozawa Osamu
HSP27 phosphorylation is correlated with ADP-induced platelet granule secretion.
Archives of biochemistry and biophysics 2008;475(1):80-6.
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2008: Tanabe Kumiko; Takai Shinji; Matsushima-Nishiwaki Rie; Kato Kanefusa; Dohi Shuji; Kozawa Osamu
Alpha2 adrenoreceptor agonist regulates protein kinase C-induced heat shock protein 27 phosphorylation in C6 glioma cells.
Journal of neurochemistry 2008;106(2):519-28.
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2008: Hayashi Kana; Takai Shinji; Matsushima-Nishiwaki Rie; Hanai Yoshiteru; Kato Kanefusa; Tokuda Haruhiko; Kozawa Osamu
(-)-Epigallocatechin gallate reduces transforming growth factor beta-stimulated HSP27 induction through the suppression of stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.
Life sciences 2008;82(19-20):1012-7.
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2008: Takai S; Hanai Y; Matsushima-Nishiwaki R; Minamitani C; Otsuka T; Tokuda H; Kozawa O
P70 S6 kinase negatively regulates fibroblast growth factor 2-stimulated interleukin-6 synthesis in osteoblasts: function at a point downstream from protein kinase C.
The Journal of endocrinology 2008;197(1):131-7.
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2008: Takai Shinji; Matsushima-Nishiwaki Rie; Adachi Seiji; Natsume Hideo; Minamitani Chiho; Mizutani Jun; Otsuka Takanobu; Tokuda Haruhiko; Kozawa Osamu
(-)-Epigallocatechin gallate reduces platelet-derived growth factor-BB-stimulated interleukin-6 synthesis in osteoblasts: suppression of SAPK/JNK.
Mediators of inflammation 2008;2008():291808.
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2008: Minamitani Chiho; Takai Shinji; Matsushima-Nishiwaki Rie; Hanai Yoshiteru; Otuka Takanobu; Kozawa Osamu; Tokuda Haruhiko
Raloxifene-induced acceleration of platelet aggregation.
Internal medicine (Tokyo, Japan) 2008;47(17):1523-8.
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2008: Tokuda Haruhiko; Takai Shinji; Hanai Yoshiteru; Harada Atsushi; Matsushima-Nishiwaki Rie; Kato Hisaaki; Ogura Shinji; Kozawa Osamu
Potentiation by platelet-derived growth factor-BB of FGF-2-stimulated VEGF release in osteoblasts.
Journal of bone and mineral metabolism 2008;26(4):335-41.
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2007: Ogiso Tomio; Nagaki Masahito; Takai Shinji; Tsukada Yoshihiko; Mukai Tsuyoshi; Kimura Kiminori; Moriwaki Hisataka
Granulocyte colony-stimulating factor impairs liver regeneration in mice through the up-regulation of interleukin-1beta.
Journal of hepatology 2007;47(6):816-25.
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2007: Tokuda Haruhiko; Hanai Yoshiteru; Matsushima-Nishiwaki Rie; Yamauchi Junichi; Doi Tomoaki; Harada Atsushi; Takai Shinji; Kozawa Osamu
Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts.
Biochemical and biophysical research communications 2007;362(4):799-804.
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2007: Tokuda Haruhiko; Takai Shinji; Hanai Yoshiteru; Harada Atsushi; Matsushima-Nishiwaki Rie; Akamatsu Shigeru; Ohta Toshiki; Kozawa Osamu
Platelet-derived growth factor-BB amplifies PGF2alpha-stimulated VEGF synthesis in osteoblasts: function of phosphatidylinositol 3-kinase.
Prostaglandins, leukotrienes, and essential fatty acids 2007;77(3-4):187-93.
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2007: Yamauchi Junichi; Takai Shinji; Matsushima-Nishiwaki Rie; Hanai Yoshiteru; Doi Tomoaki; Kato Hisaaki; Ogura Shinji; Kato Kanefusa; Tokuda Haruhiko; Kozawa Osamu
(-)-epigallocatechin gallate inhibits prostaglandin D2-stimulated HSP27 induction via suppression of the p44/p42 MAP kinase pathway in osteoblasts.
Prostaglandins, leukotrienes, and essential fatty acids 2007;77(3-4):173-9.
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2007: Takai Shinji; Matsushima-Nishiwaki Rie; Tokuda Haruhiko; Yasuda Eisuke; Toyoda Hidenori; Kaneoka Yuji; Yamaguchi Akihiro; Kumada Takashi; Kozawa Osamu
Protein kinase C delta regulates the phosphorylation of heat shock protein 27 in human hepatocellular carcinoma.
Life sciences 2007;81(7):585-91.
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2007: Noda Takahiro; Kumada Takashi; Takai Shinji; Matsushima-Nishiwaki Rie; Yoshimi Naoki; Yasuda Eisuke; Kato Kanefusa; Toyoda Hidenori; Kaneoka Yuji; Yamaguchi Akihiro; Kozawa Osamu
Expression levels of heat shock protein 20 decrease in parallel with tumor progression in patients with hepatocellular carcinoma.
Oncology reports 2007;17(6):1309-14.
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2007: Takai Shinji; Nagaki Masahito; Imao Motohiro; Kimura Kiminori; Kozawa Osamu; Moriwaki Hisataka
Intrinsic resistance to TNF-alpha-induced hepatocyte apoptosis in ICR mice correlates with expression of a short form of c-FLIP.
Laboratory investigation; a journal of technical methods and pathology 2007;87(6):572-81.
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2007: Takai Shinji; Tokuda Haruhiko; Hanai Yoshiteru; Kozawa Osamu
Limitation by p70 S6 kinase of platelet-derived growth factor-BB-induced interleukin 6 synthesis in osteoblast-like MC3T3-E1 cells.
Metabolism: clinical and experimental 2007;56(4):476-83.
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2007: Tokuda Haruhiko; Takai Shinji; Hanai Yoshiteru; Matsushima-Nishiwaki Rie; Hosoi Takayuki; Harada Atsushi; Ohta Toshiki; Kozawa Osamu
(-)-Epigallocatechin gallate suppresses endothelin-1-induced interleukin-6 synthesis in osteoblasts: inhibition of p44/p42 MAP kinase activation.
FEBS letters 2007;581(7):1311-6.
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2007: Tokuda Haruhiko; Takai Shinji; Matsushima-Nishiwaki Rie; Akamatsu Shigeru; Hanai Yoshiteru; Hosoi Takayuki; Harada Atsushi; Ohta Toshiki; Kozawa Osamu
(--)-epigallocatechin gallate enhances prostaglandin F2alpha-induced VEGF synthesis via upregulating SAPK/JNK activation in osteoblasts.
Journal of cellular biochemistry 2007;100(5):1146-53.
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2007: Takai Shinji; Tokuda Haruhiko; Hanai Yoshiteru; Kozawa Osamu
Activation of phosphatidylinositol 3-kinase/Akt limits FGF-2-induced VEGF release in osteoblasts.
Molecular and cellular endocrinology 2007;267(1-2):46-54.
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2007: Takai Shinji; Tokuda Haruhiko; Hanai Yoshiteru; Harada Atsushi; Yasuda Eisuke; Matsushima-Nishiwaki Rie; Kato Hisaaki; Ogura Shinji; Ohta Toshiki; Kozawa Osamu
Negative regulation by p70 S6 kinase of FGF-2-stimulated VEGF release through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2007;22(3):337-46.
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2006: Hanai Yoshiteru; Tokuda Haruhiko; Yasuda Eisuke; Noda Takahiro; Ohta Toshiki; Takai Shinji; Kozawa Osamu
Up-regulation by zinc of FGF-2-induced VEGF release through enhancing p44/p42 MAP kinase activation in osteoblasts.
Life sciences 2006;80(3):230-4.
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2006: Hanai Yoshiteru; Tokuda Haruhiko; Ohta Toshiki; Matsushima-Nishiwaki Rie; Takai Shinji; Kozawa Osamu
Phosphatidylinositol 3-kinase/Akt auto-regulates PDGF-BB-stimulated interleukin-6 synthesis in osteoblasts.
Journal of cellular biochemistry 2006;99(6):1564-71.
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2006: Mukai Tsuyoshi; Nagaki Masahito; Imose Motoaki; Kimura Kiminori; Satake Shinichi; Takai Shinji; Moriwaki Hisataka
Prevention of hepatic fibrosis in nonobese diabetic mice: a critical role for interferon-gamma.
Liver international : official journal of the International Association for the Study of the Liver 2006;26(8):1006-14.
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2006: Takai S; Tokuda H; Hanai Y; Kozawa O
Phosphatidylinositol 3-kinase/Akt plays a part in tumor necrosis factor-alpha-induced interleukin-6 synthesis in osteoblasts.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2006;38(9):563-9.
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2006: Takai Shinji; Akamatsu Shigeru; Yasuda Eisuke; Kozawa Osamu
[Low-molecular-weight HSP and vasopressin in vascular smooth muscle]
Nippon yakurigaku zasshi. Folia pharmacologica Japonica 2006;128(3):141-5.
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2006: Tanabe Kumiko; Tokuda Haruhiko; Takai Shinji; Matsushima-Nishiwaki Rie; Hanai Yoshiteru; Hirade Kouseki; Katagiri Yoshihiro; Dohi Shuji; Kozawa Osamu
Modulation by the steroid/thyroid hormone superfamily of TGF-beta-stimulated VEGF release from vascular smooth muscle cells.
Journal of cellular biochemistry 2006;99(1):187-95.
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2006: Takai Shinji; Tokuda Haruhiko; Yoshida Minoru; Yasuda Eisuke; Matsushima-Nishiwaki Rie; Harada Atsushi; Kato Kanefusa; Kozawa Osamu
Prostaglandin D2 induces the phosphorylation of HSP27 in osteoblasts: function of the MAP kinase superfamily.
Prostaglandins, leukotrienes, and essential fatty acids 2006;75(2):61-7.
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2006: Takai Shinji; Tokuda Haruhiko; Matsushima-Nishiwaki Rie; Hanai Yoshiteru; Kato Kanefusa; Kozawa Osamu
Phosphatidylinositol 3-kinase/Akt plays a role in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts.
Journal of cellular biochemistry 2006;98(5):1249-56.
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2006: Hanai Yoshiteru; Tokuda Haruhiko; Ishisaki Akira; Matsushima-Nishiwaki Rie; Nakamura Norimi; Yoshida Minoru; Takai Shinji; Ohta Toshiki; Kozawa Osamu
Involvement of p44/p42 MAP kinase in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblast-like-MC3T3-E1 cells.
Molecular and cellular endocrinology 2006;251(1-2):42-8.
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2006: Hanai Y; Tokuda H; Takai S; Harada A; Ohta T; Kozawa O
Minodronate suppresses prostaglandin F2alpha-induced vascular endothelial growth factor synthesis in osteoblasts.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2006;38(3):152-8.
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2005: Takai Shinji; Kimura Kiminori; Nagaki Masahito; Satake Shinichi; Kakimi Kazuhiro; Moriwaki Hisataka
Blockade of neutrophil elastase attenuates severe liver injury in hepatitis B transgenic mice.
Journal of virology 2005;79(24):15142-50.
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2005: Pagamjav Ochir; Sakata Tohru; Ibrahim El-Sayed M; Sugimoto Chihiro; Takai Shinji; Paweska Janusz T; Yamaguchi Tsuyoshi; Yasuda Jun; Fukushi Hideto
Detection of novel gammaherpesviruses in wild animals of South Africa.
The Journal of veterinary medical science / the Japanese Society of Veterinary Science 2005;67(11):1185-8.
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2005: Yasuda Eisuke; Kumada Takashi; Takai Shinji; Ishisaki Akira; Noda Takahiro; Matsushima-Nishiwaki Rie; Yoshimi Naoki; Kato Kanefusa; Toyoda Hidenori; Kaneoka Yuji; Yamaguchi Akihiro; Kozawa Osamu
Attenuated phosphorylation of heat shock protein 27 correlates with tumor progression in patients with hepatocellular carcinoma.
Biochemical and biophysical research communications 2005;337(1):337-42.
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2005: Tanabe Kumiko; Akamatsu Shigeru; Suga Hidetaka; Takai Shinji; Kato Kanefusa; Dohi Shuji; Kozawa Osamu
Midazolam suppresses thrombin-induced heat shock protein 27 phosphorylation through inhibition of p38 mitogen-activated protein kinase in cardiac myocytes.
Journal of cellular biochemistry 2005;96(1):56-64.
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2005: Shu En; Matsuno Hiroyuki; Akamastu Shigeru; Kanno Yosuke; Suga Hidetaka; Nakajima Keiichi; Ishisaki Akira; Takai Shinji; Kato Kanefusa; Kitajima Yasuo; Kozawa Osamu
alphaB-crystallin is phosphorylated during myocardial infarction: involvement of platelet-derived growth factor-BB.
Archives of biochemistry and biophysics 2005;438(2):111-8.
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2005: Suga Hidetaka; Nakajima Keiichi; Shu En; Kanno Yosuke; Hirade Kouseki; Ishisaki Akira; Matsuno Hiroyuki; Tanabe Kumiko; Takai Shinji; Akamatsu Shigeru; Kato Kanefusa; Oiso Yutaka; Kozawa Osamu
Possible involvement of phosphatidylinositol 3-kinase/Akt signal pathway in vasopressin-induced HSP27 phosphorylation in aortic smooth muscle A10 cells.
Archives of biochemistry and biophysics 2005;438(2):137-45.
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2005: Noda T; Tokuda H; Yoshida M; Yasuda E; Hanai Y; Takai S; Kozawa O
Possible involvement of phosphatidylinositol 3-kinase/Akt pathway in insulin-like growth factor-I-induced alkaline phosphatase activity in osteoblasts.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2005;37(5):270-4.
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2005: Hayashi Hideki; Nagaki Masahito; Imose Motoaki; Osawa Yosuke; Kimura Kiminori; Takai Shinji; Imao Motohiro; Naiki Takafumi; Kato Tomohiro; Moriwaki Hisataka
Normal liver regeneration and liver cell apoptosis after partial hepatectomy in tumor necrosis factor-alpha-deficient mice.
Liver international : official journal of the International Association for the Study of the Liver 2005;25(1):162-70.
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2005: Takai Shinji; Tsurumi Hisashi; Ando Kazuki; Kasahara Senji; Sawada Michio; Yamada Toshiki; Hara Takeshi; Fukuno Kenji; Takahashi Takeshi; Oyama Masami; Onishi Hiroo; Tomita Eiichi; Takami Tsuyoshi; Imawari Michio; Moriwaki Hisataka
Prevalence of hepatitis B and C virus infection in haematological malignancies and liver injury following chemotherapy.
European journal of haematology 2005;74(2):158-65.
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2004: Kimura Kiminori; Nagaki Masahito; Takai Shinji; Satake Shinichi; Moriwaki Hisataka
Pivotal role of nuclear factor kappaB signaling in anti-CD40-induced liver injury in mice.
Hepatology (Baltimore, Md.) 2004;40(5):1180-9.
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2004: Imose Motoaki; Nagaki Masahito; Kimura Kiminori; Takai Shinji; Imao Motohiro; Naiki Takafumi; Osawa Yosuke; Asano Takahiko; Hayashi Hideki; Moriwaki Hisataka
Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor kappaB.
Hepatology (Baltimore, Md.) 2004;40(5):1160-9.
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