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Hiroshi Takaku

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
59
Miyano-Kurosaki, Naoko
57
Takai, K
36
Yokoyama, Shigeyuki
23
Yamamoto, Naoki
21
Kawai, Gota
18
Takagi, Masamichi
16
Nashimoto, Masayuki
16
Hatta, T
15
Hosono, Kazumi
14
Tsukahara, S
14
Takeuchi, Hiroaki
11
Yokota, T
11
Abe, T
11
Habu, Yuichiro
10
Minagawa, Asako

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Publications

TOP 3
Sugiyama Ryuichi; Habu Yuichiro; Ohnari Aki; Miyano-Kurosaki Naoko; Takaku Hiroshi
RNA interference targeted to the conserved dimerization initiation site (DIS) of HIV-1 restricts virus escape mutation.
Barnor Jacob S; Habu Yuichiro; Yamamoto Norio; Miyano-Kurosaki Naoko; Ishikawa Koichi; Yamamoto Naoki; Takaku Hiroshi
Inhibition of HIV-1 replication by long-term treatment with a chimeric RNA containing shRNA and TAR decoy RNA.
Mondal Nazrul Islam; Takaku Hiroshi; Ohkusa Yasushi; Sugawara Tamie; Okabe Nobuhiko
HIV/AIDS acquisition and transmission in Bangladesh: turning to the concentrated epidemic.

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All Publications

2009: Sugiyama Ryuichi; Habu Yuichiro; Ohnari Aki; Miyano-Kurosaki Naoko; Takaku Hiroshi
RNA interference targeted to the conserved dimerization initiation site (DIS) of HIV-1 restricts virus escape mutation.
Journal of biochemistry 2009;146(4):481-9.
2009: Barnor Jacob S; Habu Yuichiro; Yamamoto Norio; Miyano-Kurosaki Naoko; Ishikawa Koichi; Yamamoto Naoki; Takaku Hiroshi
Inhibition of HIV-1 replication by long-term treatment with a chimeric RNA containing shRNA and TAR decoy RNA.
Antiviral research 2009;83(2):156-64.
2009: Mondal Nazrul Islam; Takaku Hiroshi; Ohkusa Yasushi; Sugawara Tamie; Okabe Nobuhiko
HIV/AIDS acquisition and transmission in Bangladesh: turning to the concentrated epidemic.
Japanese journal of infectious diseases 2009;62(2):111-9.
2009: Ujino Saneyuki; Yamaguchi Saori; Shimotohno Kunitada; Takaku Hiroshi
Heat-shock protein 90 is essential for stabilization of the hepatitis C virus nonstructural protein NS3.
The Journal of biological chemistry 2009;284(11):6841-6.
2009: Suzuki Hitoshi; Matsumoto Norihiko; Suzuki Tomoyuki; Chang Myint Oo; Takaku Hiroshi
Stable replication of the EBNA1/OriP-mediated baculovirus vector and its application to anti-HCV gene therapy.
Virology journal 2009;6():156.
2009: Suzuki Hitoshi; Saitoh Hiroshi; Suzuki Tomoyuki; Takaku Hiroshi
Inhibition of influenza virus by baculovirus-mediated shRNA.
Nucleic acids symposium series (2004) 2009;(53):287-8.
2009: Mondal Nazrul Islam; Takaku Hiroshi; Ohkusa Yasushi
Impact of age at marriage and migration on HIV and AIDS epidemics in Japan.
International journal for equity in health 2009;8():23.
2008: Elbarbary Reyad A; Takaku Hiroaki; Nashimoto Masayuki
Functional analyses for tRNase Z variants: an aspartate and a histidine in the active site are essential for the catalytic activity.
Biochimica et biophysica acta 2008;1784(12):2079-85.
2008: Suzuki Hitoshi; Tamai Nobushige; Habu Yuichiro; Chang Myint O O; Takaku Hiroshi
Suppression of hepatitis C virus replication by baculovirus vector-mediated short-hairpin RNA expression.
FEBS letters 2008;582(20):3085-9.
2008: Takahashi Masayuki; Takaku Hiroaki; Nashimoto Masayuki
Regulation of the human tRNase ZS gene expression.
FEBS letters 2008;582(17):2532-6.
2008: Nishibe Y; Kaneko H; Suzuki H; Abe T; Matsuura Y; Takaku H
Baculovirus-mediated interferon alleviates dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model.
Gene therapy 2008;15(13):990-7.
2008: Someya Tatsuhiko; Hosono Kazumi; Morimura Kaori; Takaku Hiroshi; Kawai Gota
Recognition of a bulged RNA by peptides derived from the influenza NS1 protein.
Journal of biochemistry 2008;143(3):339-47.
2008: Gondai Takuma; Yamaguchi Kazuya; Miyano-Kurosaki Naoko; Habu Yuichirou; Takaku Hiroshi
Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon.
Nucleic acids research 2008;36(3):e18.
2008: Kitajima Masayuki; Takaku Hiroshi
Induction of antitumor acquired immunity by baculovirus Autographa californica multiple nuclear polyhedrosis virus infection in mice.
Clinical and vaccine immunology : CVI 2008;15(2):376-8.
2008: Kato Keijiro; Habu Yuichiro; Takaku Hiroshi
Micro RNA like inhibition of HIV-1 replication.
Nucleic acids symposium series (2004) 2008;(52):509-10.
2007: Ishii Ryohei; Minagawa Asako; Takaku Hiroaki; Takagi Masamichi; Nashimoto Masayuki; Yokoyama Shigeyuki
The structure of the flexible arm of Thermotoga maritima tRNase Z differs from those of homologous enzymes.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 8):637-41.
2007: Nakashima A; Takaku H; Shibata H S; Negishi Y; Takagi M; Tamura M; Nashimoto M
Gene silencing by the tRNA maturase tRNase ZL under the direction of small-guide RNA.
Gene therapy 2007;14(1):78-85.
2007: Suzuki Hitoshi; Kaneko Hiroyasu; Tamai Nobushige; Shimotohno Kunitada; Miyano-Kurosaki Naoko; Takaku Hiroshi
Suppression of hepatitis C virus core protein by short hairpin RNA expression vectors in the core protein expression Huh-7 cells.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):815-20.
2007: Gondai Takuma; Yamaguchi Kazuya; Hashimoto Kahoko; Miyano-Kurosaki Naoko; Takaku Hiroshi
Lack of interferon (IFN) response to T7 Transcribed pppG (n)(n = 2,3)-shRNA.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):805-8.
2007: Kato Keijiro; Habu Yuichiro; Takaku Hiroshi
Non-sequence specific RNA inhibition of HIV-1 replication.
Nucleic acids symposium series (2004) 2007;(51):411-2.
2007: Noguchi Kousei; Ishitu Yoshio; Miyano-Kurosaki Naoko; Takaku Hiroshi
Expression of shRNA using intron splicing.
Nucleic acids symposium series (2004) 2007;(51):409-10.
2006: Miyano-Kurosaki Naoko; Kurosaki Kunihiko; Hayashi Michiko; Takaku Hiroshi; Hayafune Masaaki; Shirato Ken; Kasuga Teruhiko; Endo Takahiko; Tomoda Akio
2-aminophenoxazine-3-one suppresses the growth of mouse malignant melanoma B16 cells transplanted into C57BL/6Cr Slc mice.
Biological & pharmaceutical bulletin 2006;29(11):2197-201.
2006: Takaku Hiroaki; Kimoto Ayumi; Kodaira Shoko; Nashimoto Masayuki; Takagi Masamichi
Isolation of a Gram-positive poly(3-hydroxybutyrate) (PHB)-degrading bacterium from compost, and cloning and characterization of a gene encoding PHB depolymerase of Bacillus megaterium N-18-25-9.
FEMS microbiology letters 2006;264(2):152-9.
2006: Kaneko Hiroyasu; Suzuki Hitoshi; Abe Takashi; Miyano-Kurosaki Naoko; Takaku Hiroshi
Inhibition of HIV-1 replication by vesicular stomatitis virus envelope glycoprotein pseudotyped baculovirus vector-transduced ribozyme in mammalian cells.
Biochemical and biophysical research communications 2006;349(4):1220-7.
2006: Minagawa Asako; Takaku Hiroaki; Shibata Hirotaka S; Ishii Ryohei; Takagi Masamichi; Yokoyama Shigeyuki; Nashimoto Masayuki
Substrate recognition ability differs among various prokaryotic tRNase Zs.
Biochemical and biophysical research communications 2006;345(1):385-93.
2006: Shibata Hirotaka S; Minagawa Asako; Takaku Hiroaki; Takagi Masamichi; Nashimoto Masayuki
Unstructured RNA is a substrate for tRNase Z.
Biochemistry 2006;45(17):5486-92.
2006: Hamazaki Hiroyuki; Ujino Saneyuki; Miyano-Kurosaki Naoko; Shimotohno Kunitada; Takaku Hiroshi
Inhibition of hepatitis C virus RNA replication by short hairpin RNA synthesized by T7 RNA polymerase in hepatitis C virus subgenomic replicons.
Biochemical and biophysical research communications 2006;343(3):988-94.
2006: Kitajima Masayuki; Hamazaki Hiroyuki; Miyano-Kurosaki Naoko; Takaku Hiroshi
Characterization of baculovirus Autographa californica multiple nuclear polyhedrosis virus infection in mammalian cells.
Biochemical and biophysical research communications 2006;343(2):378-84.
2006: Takaku Hiroaki; Kodaira Shoko; Kimoto Ayumi; Nashimoto Masayuki; Takagi Masamichi
Microbial communities in the garbage composting with rice hull as an amendment revealed by culture-dependent and -independent approaches.
Journal of bioscience and bioengineering 2006;101(1):42-50.
2006: Hayafune Masaaki; Miyano-Kurosaki Naoko; Park Wee-Sung; Moori Yuka; Takaku Hiroshi
Silencing of HIV-1 gene expression by two types of siRNA expression systems.
Antiviral chemistry & chemotherapy 2006;17(5):241-9.
2006: Hayafune Masaaki; Miyano-Kurosaki Naoko; Kusunoki Akiko; Mouri Yuka; Takaku Hiroshi
HIV gene therapy using RNA virus systems.
Nucleic acids symposium series (2004) 2006;(50):79-80.
2006: Minagawa Asako; Takaku Hiroaki; Ishii Ryohei; Takagi Masamichi; Yokoyama Shigeyuki; Nashimoto Masayuki
Identification by Mn2+ rescue of two residues essential for the proton transfer of tRNase Z catalysis.
Nucleic acids research 2006;34(13):3811-8.
2006: Hamazaki Hiroyuki; Takahashi Hitoshi; Shimotohno Kunitada; Miyano-Kurosaki Naoko; Takaku Hiroshi
Inhibition of hcv replication in HCV replicon by shRNAs.
Nucleosides, nucleotides & nucleic acids 2006;25(7):801-5.
2006: Hayafune Masaaki; Miyano-Kurosaki Naoko; Takaku Hiroshi; Park Wee-Sung
Silencing of HIV-1 gene expression by siRNAs in transduced cells.
Nucleosides, nucleotides & nucleic acids 2006;25(7):795-9.
2006: Ikeda Masahiro; Habu Yuichiro; Miyano-Kurosaki Naoko; Takaku Hiroshi
Suppression of HIV-1 replication by a combination of endonucleolytic ribozymes (RNase P and tRNnase ZL).
Nucleosides, nucleotides & nucleic acids 2006;25(4-6):427-37.
2005: Nameki Nobukazu; Someya Tatsuhiko; Okano Satoshi; Suemasa Reiko; Kimoto Michiko; Hanawa-Suetsugu Kyoko; Terada Takaho; Shirouzu Mikako; Hirao Ichiro; Takaku Hiroshi; Himeno Hyouta; Muto Akira; Kuramitsu Seiki; Yokoyama Shigeyuki; Kawai Gota
Interaction analysis between tmRNA and SmpB from Thermus thermophilus.
Journal of biochemistry 2005;138(6):729-39.
2005: Baba Seiki; Takahashi Ken-ichi; Noguchi Satoko; Takaku Hiroshi; Koyanagi Yoshio; Yamamoto Naoki; Kawai Gota
Solution RNA structures of the HIV-1 dimerization initiation site in the kissing-loop and extended-duplex dimers.
Journal of biochemistry 2005;138(5):583-92.
2005: Shibata Hirotaka S; Takaku Hiroaki; Takagi Masamichi; Nashimoto Masayuki
The T loop structure is dispensable for substrate recognition by tRNase ZL.
The Journal of biological chemistry 2005;280(23):22326-34.
2005: Minagawa Asako; Takaku Hiroaki; Takagi Masamichi; Nashimoto Masayuki
The missense mutations in the candidate prostate cancer gene ELAC2 do not alter enzymatic properties of its product.
Cancer letters 2005;222(2):211-5.
2005: Hayashi Mieko; Satou Emi; Ueki Ryouji; Yano Mayuka; Miyano-Kurosaki Naoko; Fujii Masayuki; Takaku Hiroshi
Resistance to influenza A virus infection by antigen-conjugated CpG oligonucleotides, a novel antigen-specific immunomodulator.
Biochemical and biophysical research communications 2005;329(1):230-6.
2005: Ishii Ryohei; Minagawa Asako; Takaku Hiroaki; Takagi Masamichi; Nashimoto Masayuki; Yokoyama Shigeyuki
Crystal structure of the tRNA 3' processing endoribonuclease tRNase Z from Thermotoga maritima.
The Journal of biological chemistry 2005;280(14):14138-44.
2005: Suzuki Hitoshi; Kaneko Hiroyasu; Tamai Nobushige; Miyano-Kurosaki Naoko; Hashimoto Kahoko; Shimotohno Kunitada; Takaku Hiroshi
Suppression of HCV RNA replication by baculovirus-mediated shRNA expression.
Nucleic acids symposium series (2004) 2005;(49):339-40.
2005: Habu Yuichiro; Nagawa Takashi; Matsumoto Norihiko; Takeuchi Hiroaki; Miyano-Kurosaki Naoko; Takaku Hiroshi
Suppression of human immunodeficiency virus type 1 (HIV-1) replication by an HIV-1-dependent double locked vector with the Cre/loxP system.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1907-17.
2005: Barnor Jacob Samson; Miyano-Kurosaki Naoko; Takaku Hiroshi; Yamaguchi Kazuya; Sakamoto Atsushi; Ishikawa Koichi; Yamamoto Naoki; Osei-Kwasi Mubarak; Ofori-Adjei David
The middle to 3' end of the HIV-1 vif gene sequence is important for vif biological activity and could be used for antisense oligonucleotide targets.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1745-61.
2005: Kitajima Masayuki; Tsuyama Youichi; Miyano-Kurosaki Naoko; Takaku Hiroshi
Anti-tumor effect of intravenous TNFalpha gene delivery naked plasmid DNA using a hydrodynamics-based procedure.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):647-50.
2005: Habu Yuichiro; Miyano-Kurosaki Naoko; Kitano Michiko; Endo Yumihiko; Yukita Masakazu; Ohira Shigeru; Takaku Hiroaki; Nashimoto Masayuki; Takaku Hiroshi
Inhibition of HIV-1 gene expression by retroviral vector-mediated small-guide RNAs that direct specific RNA cleavage by tRNase ZL.
Nucleic acids research 2005;33(1):235-43.
2005: Habu Yuichiro; Miyano-Kurosaki Naoko; Kitano Michiko; Endo Yumihiko; Yukita Masakazu; Ohira Shigeru; Takaku Hiroaki; Nashimoto Masayuki; Takaku Hiroshi
Inhibition of HIV-1 gene expression by retroviral vector-mediated small-guide RNAs that direct specific RNA cleavage by tRNase ZL.
Nucleic acids research 2005;33(1):235-43.
2004: Barnor Jacob S; Endo Yumihiko; Habu Yuichiro; Miyano-Kurosaki Naoko; Kitano Michiko; Yamamoto Hirokazu; Takaku Hiroshi
Effective inhibition of HIV-1 replication in cultured cells by external guide sequences and ribonuclease P.
Bioorganic & medicinal chemistry letters 2004;14(19):4941-4.
2004: Barnor Jacob Samson; Miyano-Kurosaki Naoko; Yamaguchi Kazuya; Sakamoto Atsushi; Ishikawa Koichi; Inagaki Yoshio; Yamamoto Naoki; Osei-Kwasi Mubarak; Ofori-Adjei David; Takaku Hiroshi
Intracellular expression of antisense RNA transcripts complementary to the human immunodeficiency virus type-1 vif gene inhibits viral replication in infected T-lymphoblastoid cells.
Biochemical and biophysical research communications 2004;320(2):544-50.
2004: Takaku Hiroaki; Mutoh Eishun; Sagehashi Yoshiyuki; Fukuda Ryouichi; Horiuchi Hiroyuki; Ochi Kozo; Takagi Masamichi; Ohta Akinori
A Gcn4p homolog is essential for the induction of a ribosomal protein L41 variant responsible for cycloheximide resistance in the yeast Candida maltosa.
The Journal of biological chemistry 2004;279(22):23030-7.
2004: Minagawa Asako; Takaku Hiroaki; Takagi Masamichi; Nashimoto Masayuki
A novel endonucleolytic mechanism to generate the CCA 3' termini of tRNA molecules in Thermotoga maritima.
The Journal of biological chemistry 2004;279(15):15688-97.
2004: Miyano-Kurosaki Naoko; Barnor Jacob Samson; Takeuchi Hiroaki; Owada Takashi; Nakashima Hideki; Yamamoto Naoki; Matsuzaki Tetsuo; Shimada Fumiyuki; Takaku Hiroshi
In vitro and in vivo transport and delivery of phosphorothioate oligonucleotides with cationic liposomes.
Antiviral chemistry & chemotherapy 2004;15(2):93-100.
2004: Takahashi Hitoshi; Hamazaki Hiroyuki; Habu Yuichiro; Hayashi Mieko; Abe Takayuki; Miyano-Kurosaki Naoko; Takaku Hiroshi
A new modified DNA enzyme that targets influenza virus A mRNA inhibits viral infection in cultured cells.
FEBS letters 2004;560(1-3):69-74.
2004: Hamazaki Hiroyuki; Ujino Saneyuki; Abe Emi; Miyano-Kurosaki Naoko; Shimotohno Kunitada; Takaku Hiroshi
RNAi expression mediated inhibition of HCV replication.
Nucleic acids symposium series (2004) 2004;(48):307-8.
2004: Tsuyama Youichi; Kitajima Masayuki; Miyano-Kurosaki Naoko; Takaku Hiroshi
Anti-tumor effects of naked plasmid DNA using a hydrodynamics-based procedure.
Nucleic acids symposium series (2004) 2004;(48):239-40.
2004: Takaku Hiroaki; Minagawa Asako; Takagi Masamichi; Nashimoto Masayuki
The N-terminal half-domain of the long form of tRNase Z is required for the RNase 65 activity.
Nucleic acids research 2004;32(15):4429-38.
2004: Takaku Hiroaki; Minagawa Asako; Takagi Masamichi; Nashimoto Masayuki
A novel 4-base-recognizing RNA cutter that can remove the single 3' terminal nucleotides from RNA molecules.
Nucleic acids research 2004;32(11):e91.
2003: Baba Seiki; Takahashi Ken-Ichi; Koyanagi Yoshio; Yamamoto Naoki; Takaku Hiroshi; Gorelick Robert J; Kawai Gota
Role of the zinc fingers of HIV-1 nucleocapsid protein in maturation of genomic RNA.
Journal of biochemistry 2003;134(5):637-9.
2003: Park W-S; Hayafune M; Miyano-Kurosaki N; Takaku H
Specific HIV-1 env gene silencing by small interfering RNAs in human peripheral blood mononuclear cells.
Gene therapy 2003;10(24):2046-50.
2003: Abe Takayuki; Takahashi Hitoshi; Hamazaki Hiroyuki; Miyano-Kurosaki Naoko; Matsuura Yoshiharu; Takaku Hiroshi
Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1133-9.
2003: Takaku Hiroaki; Minagawa Asako; Takagi Masamichi; Nashimoto Masayuki
A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease.
Nucleic acids research 2003;31(9):2272-8.
2003: Kuwasaki Tomoyuki; Hatta Masasi; Takeuchi Hiroaki; Takaku Hiroshi
Inhibition of human immunodeficiency virus 1 replication in vitro by a self-stabilized oligonucleotide with 2'-O-methyl-guanosine-uridine quadruplex motifs.
The Journal of antimicrobial chemotherapy 2003;51(4):813-9.
2003: Ichiyama Kozi; Yokoyama-Kumakura Sei; Tanaka Yuetsu; Tanaka Reiko; Hirose Kunitaka; Bannai Kenji; Edamatsu Takeo; Yanaka Mikiro; Niitani Yoshiaki; Miyano-Kurosaki Naoko; Takaku Hiroshi; Koyanagi Yoshio; Yamamoto Naoki
A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4185-90.
2003: Kusunoki Akiko; Miyano-Kurosaki Naoko; Takaku Hiroshi
A novel single-stranded DNA enzyme expression system using HIV-1 reverse transcriptase.
Biochemical and biophysical research communications 2003;301(2):535-9.
2003: Hayashi Mieko; Kuwahara Makoto; Ogata Miwa; Miyao-Kurosaki Naoko; Abel Takayuki; Ueki Ryouji; Yano Mayuka; Fujii Masayuki; Hartmann Gunther; Takaku Hiroshi
Evaluating the immune responses stimulated by CpG oligodeoxynucleotides.
Nucleic acids research. Supplement (2001) 2003;(3):323-4.
2002: Park Wee-Sung; Miyano-Kurosaki Naoko; Hayafune Masaaki; Nakajima Emiko; Matsuzaki Tetsuo; Shimada Fumiyuki; Takaku Hiroshi
Prevention of HIV-1 infection in human peripheral blood mononuclear cells by specific RNA interference.
Nucleic acids research 2002;30(22):4830-5.
2002: Habu Yuichiro; Miyano-Kurosaki Naoko; Nagawa Takashi; Matsumoto Norihiko; Takeuchi Hiroaki; Takaku Hiroshi
Inhibition of HIV-1 replication by an HIV-1 dependent ribozyme expression vector with the Cre/loxP (ON/OFF) system.
Antiviral chemistry & chemotherapy 2002;13(5):273-81.
2002: Takaku Hiroaki; Horiuchi Hiroyuki; Takagi Masamichi; Ohta Akinori
Pseudohyphal growth in a dimorphic yeast, Candida maltosa, after disruption of the C-GCN4 gene, a homolog of Saccharomyces cerevisiae GCN4.
Bioscience, biotechnology, and biochemistry 2002;66(9):1936-9.
2002: Inagawa Takubumi; Nakashima Hideki; Karwowski Boleslaw; Guga Piotr; Stec Wojciech J; Takeuchi Hiroaki; Takaku Hiroshi
Inhibition of human immunodeficiency virus type 1 replication by P-stereodefined oligo(nucleoside phosphorothioate)s in a long-term infection model.
FEBS letters 2002;528(1-3):48-52.
2002: Kitamura Aya; Muto Yutaka; Watanabe Satoru; Kim Insil; Ito Takuhiro; Nishiya Yoichi; Sakamoto Kensaku; Ohtsuki Takashi; Kawai Gota; Watanabe Kimitsuna; Hosono Kazumi; Takaku Hiroshi; Katoh Etsuko; Yamazaki Toshimasa; Inoue Tan; Yokoyama Shigeyuki
Solution structure of an RNA fragment with the P7/P9.0 region and the 3'-terminal guanosine of the tetrahymena group I intron.
RNA (New York, N.Y.) 2002;8(4):440-51.
2002: Suzuki Jun-ichiro; Miyano-Kurosaki Naoko; Kuwasaki Tomoyuki; Takeuchi Hiroaki; Kawai Gota; Takaku Hiroshi
Inhibition of human immunodeficiency virus type 1 activity in vitro by a new self-stabilized oligonucleotide with guanosine-thymidine quadruplex motifs.
Journal of virology 2002;76(6):3015-22.
2002: Yukita Masakazu; Kitano Michiko; Miyano-Kurosaki Naoko; Takeuchi Hiroaki; Nashimoto Masayuki; Takaku Hiroshi
RNA cleavage by a mammalian tRNA 3'processing endoribonuclease (3'tRNase) reduces HIV-1 expression.
Nucleic acids research. Supplement (2001) 2002;(2):297-8.
2002: Nagawa Takashi; Habu Yuichiro; Matsumoto Norihiko; Takeuchi Hiroaki; Kurosaki Naoko; Takaku Hiroshi
Development of HIV-1 dependent gene expression vector with the Cre/loxP (ON) system.
Nucleic acids research. Supplement (2001) 2002;(2):295-6.
2002: Barnor Jacob Samson; Miyano-Kurosaki Naoko; Yamaguchi Kazuya; Kobayashi Hiroki; Ishikawa Koichi; Osei-Kwasi Mubarak; Ampofo William Kwabina; Ofori-Adjei David; Inagaki Yoshio; Yamamoto Naoki; Takaku Hiroshi
Down regulation of human immunodeficiency virus type-1 (HIV-1) expression by Vif antisense RNA expression vectors in transfected cells.
Nucleic acids research. Supplement (2001) 2002;(2):123-4.
2001: Tado M; Abe T; Hatta T; Ishikawa M; Nakada S; Yokota T; Takaku H
Inhibitory effect of modified 5'-capped short RNA fragments on influenza virus RNA polymerase gene expression.
Antiviral chemistry & chemotherapy 2001;12(6):353-8.
2001: Ushijima K; Shirakawa M; Kagoshima K; Park W S; Miyano-Kurosaki N; Takaku H
Anti-HIV-1 activity of an antisense phosphorothioate oligonucleotide bearing imidazole and primary amine groups.
Bioorganic & medicinal chemistry 2001;9(8):2165-9.
2001: Takahashi K; Baba S; Koyanagi Y; Yamamoto N; Takaku H; Kawai G
Two basic regions of NCp7 are sufficient for conformational conversion of HIV-1 dimerization initiation site from kissing-loop dimer to extended-duplex dimer.
The Journal of biological chemistry 2001;276(33):31274-8.
2001: Takaku H; Mutoh E; Horiuchi H; Ohta A; Takagi M
Ray38p, a homolog of a purine motif triple-helical DNA-binding protein, Stm1p, is a ribosome-associated protein and dissociated from ribosomes prior to the induction of cycloheximide resistance in Candida maltosa.
Biochemical and biophysical research communications 2001;284(1):194-202.
2001: Habu Y; Miyano-Kurosaki N; Takeuchi H; Matsumoto N; Tamura Y; Takaku H
Inhibition of HIV-1 replication by the Cre-loxP hammerhead ribozyme.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):723-6.
2001: Kitano M; Barnor J S; Miyano-Kurosaki N; Endo Y; Yukita M; Takeuchi H; Tamura Y; Takai K; Nashimoto M; Takaku H
Effective suppression of HIV-1 gene expression by a mammalian tRNA 3' processing endoribonuclease and external guide sequence oligozymes.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):719-22.
2001: Hiratou T; Miyano-Kurosaki N; Gushima H; Takaku H
A new class of anti-HIV-1 oligonucleotide targeted to the polypurine tract of viral RNA.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):715-8.
2001: Abe T; Mizuta T; Hatta T; Miyano-Kurosaki N; Fujiwara M; Takai K; Shigeta S; Yokota T; Takaku H
Antisense therapy of influenza.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;13(1):61-9.
2001: Kusunoki A; Saitou T; Miyano-Kurosaki N; Takaku H
Inhibition of the human chemokine receptor CXCR4 by antisense phosphorothioate oligodeoxyribonucleotides.
FEBS letters 2001;488(1-2):64-8.
2001: Park W S; Miyano-Kurosaki N; Nakajima E; Takaku H
Specific inhibition of HIV-1 gene expression by double-stranded RNA.
Nucleic acids research. Supplement (2001) 2001;(1):219-20.
2001: Endo Y; Miyano-Kurosaki N; Kitano M; Habu Y; Takaku H
Effective inhibition of HIV-1 replication in cultured cells by external guide sequences and ribonuclease.
Nucleic acids research. Supplement (2001) 2001;(1):213-4.
2001: Baba S; Takahashi K; Nomura Y; Noguchi S; Koyanagi Y; Yamamoto N; Takaku H; Kawai G
Conformational change of dimerization initiation site of HIV-1 genomic RNA by NCp7 or heat treatment.
Nucleic acids research. Supplement (2001) 2001;(1):155-6.
2001: Nishitsuji H; Tamura Y; Fuse T; Habu Y; Miyano-Kurosaki N; Takaku H
Inhibition of HIV-1 replication by 5'LTR decoy RNA.
Nucleic acids research. Supplement (2001) 2001;(1):141-2.
2000: Abe T; Takaku H
[Protection against influenza by genetically engineered vaccines]
Nippon rinsho. Japanese journal of clinical medicine 2000;58(11):2313-20.
2000: Hosaka H; Hosono K; Kawai G; Takai K; Takaku H
Self-cleavage of p2Sp1 RNA with Mg2+ and non-ionic detergent (Brij 58).
Journal of inorganic biochemistry 2000;82(1-4):215-9.
2000: Hiratou T; Tsukahara S; Miyano-Kurosaki N; Takai K; Saito T; Yamamoto N; Takaku H
Anti-HIV-1 activity by a triple-helix forming oligonucleotides targeted to polypurine tract on viral RNA.
Nucleosides, nucleotides & nucleic acids 2000;19(10-12):1721-34.
2000: Kusunoki A; Miyano-Kurosaki N; Kimura T; Takai K; Yamamoto N; Gushima H; Takaku H
Antisense phosphorothioate oligonucleotides targeted to the human chemokine receptor CXCR4.
Nucleosides, nucleotides & nucleic acids 2000;19(10-12):1709-19.
2000: Kim I; Muto Y; Watanabe S; Kitamura A; Futamura Y; Yokoyama S; Hosono K; Kawai G; Takaku H; Dohmae N; Takio K; Saskamoto H; Shimura Y
Interactions of a didomain fragment of the Drosophila sex-lethal protein with single-stranded uridine-rich oligoribonucleotides derived from the transformer and Sex-lethal messenger RNA precursors: NMR with residue-selective [5-2H]uridine substitutions.
Journal of biomolecular NMR 2000;17(2):153-65.
2000: Satoh A; Takai K; Ouchi R; Yokoyama S; Takaku H
Effects of anticodon 2'-O-methylations on tRNA codon recognition in an Escherichia coli cell-free translation.
RNA (New York, N.Y.) 2000;6(5):680-6.
2000: Tamura Y; Tao M; Miyano-Kurosaki N; Takai K; Takaku H
Inhibition of human telomerase activity by antisense phosphorothioate oligonucleotides encapsulated with the transfection reagent, FuGENE6, in HeLa cells.
Antisense & nucleic acid drug development 2000;10(2):87-96.
2000: Kanda T; Takai K; Hohsaka T; Sisido M; Takaku H
Sense codon-dependent introduction of unnatural amino acids into multiple sites of a protein.
Biochemical and biophysical research communications 2000;270(3):1136-9.
2000: Takahashi K; Baba S; Hayashi Y; Koyanagi Y; Yamamoto N; Takaku H; Kawai G
NMR analysis of intra- and inter-molecular stems in the dimerization initiation site of the HIV-1 genome.
Journal of biochemistry 2000;127(4):681-6.
2000: Kanda T; Takai K; Yokoyama S; Takaku H
Specific inactivation of Escherichia coli tRNA(Phe) by antisense DNA-treatment under Mg2+-deficient conditions.
Bioorganic & medicinal chemistry 2000;8(3):675-9.
2000: Hiratou T; Miyano-Kurosaki N; Tsukahara S; Tamura Y; Takai K; Yamamoto N; Takaku H
Anti-human immunodeficiency virus type 1 of a two-strand-system targeted to the polypurine tract.
International journal of molecular medicine 2000;5(2):125-32.
2000: Kanda T; Takai K; Yokoyama S; Takaku H
An easy cell-free protein synthesis system dependent on the addition of crude Escherichia coli tRNA.
Journal of biochemistry 2000;127(1):37-41.
2000: Takahashi K I; Baba S; Chattopadhyay P; Koyanagi Y; Yamamoto N; Takaku H; Kawai G
Structural requirement for the two-step dimerization of human immunodeficiency virus type 1 genome.
RNA (New York, N.Y.) 2000;6(1):96-102.
2000: Takahashi H; Abe T; Takai K; Takaku H
Inhibition of influenza virus RNA (PB2 mRNA) expression by a modified DNA enzyme.
Nucleic acids symposium series 2000;(44):287-8.
2000: Kitano M; Miyano-Kurosaki N; Endo Y; Yukita M; Takeuchi H; Tamura Y; Takai K; Nashimoto M; Takaku H
Effective suppression of HIV-1 gene expression by a mammalian tRNA 3' processing endoribonuclease and external guide sequence oligozymes.
Nucleic acids symposium series 2000;(44):207-8.
2000: Tamura Y; Yoshida M; Suzuki J; Hiratou T; Miyano-Kurosaki N; Takai K; Takaku H
Properties of quadruplex oligonucleotides with anti-HIV-1 activity.
Nucleic acids symposium series 2000;(44):181-2.
1999: Hosono K; Hosaka H; Kawai G; Takai K; Takaku H
The stem hairpin loop structure of p2Sp1 RNA is required for RNA-cleaving activity.
Biochimica et biophysica acta 1999;1489(2-3):374-82.
1999: Hosoya T; Takeuchi H; Kanesaka Y; Yamakawa H; Miyano-Kurosaki N; Takai K; Yamamoto N; Takaku H
Sequence-specific inhibition of a transcription factor by circular dumbbell DNA oligonucleotides.
FEBS letters 1999;461(3):136-40.
1999: Kumar P; Takaku H
Properties of mixed backbone oligonucleotides containing 3'-O-methyl ribonucleosides.
Bioorganic & medicinal chemistry letters 1999;9(17):2515-20.
1999: Hiratou T; Tsukahara S; Miyano-Kurosaki N; Takai K; Yamamoto N; Takaku H
Inhibition of HIV-1 replication by a two-strand system (FTFOs) targeted to the polypurine tract.
FEBS letters 1999;456(1):186-90.
1999: Tao M; Miyano-Kurosaki N; Takai K; Takaku H
Specific inhibition of human telomerase activity by transfection reagent, FuGENE6-antisense phosphorothioate oligonucleotide complex in HeLa cells.
FEBS letters 1999;454(3):312-6.
1999: Kusunoki A; Wada A; Kurosaki N; Kimura T; Takai K; Yamamoto N; Takaku H
Antisense oligodeoxynucleotide complementary to CXCR4 mRNA block replication of HIV-1 in COS cells.
Nucleosides & nucleotides 1999;18(6-7):1705-8.
1999: Abe T; Mizuta T; Suzuki S; Hatta T; Takai K; Yokota T; Takaku H
In vitro and in vivo anti-influenza A virus activity of antisense oligonucleotides.
Nucleosides & nucleotides 1999;18(6-7):1685-8.
1999: Mizuta T; Fujiwara M; Hatta T; Abe T; Miyano-Kurosaki N; Shigeta S; Yokota T; Takaku H
Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A.
Nature biotechnology 1999;17(6):583-7.
1999: Ushijima K; Ishibashi T; Yamakawa H; Tsukahara S; Takai K; Maruyama T; Takaku H
Inhibition of restriction endonuclease cleavage by triple helix formation with RNA and 2'-O-methyl RNA oligonucleotides containing 8-oxo-adenosine in place of cytidine.
Biochemistry 1999;38(20):6570-5.
1999: Mutoh E; Takaku H; Ohta A; Takagi M
A gene coding for a ribosomal protein L41 in cycloheximide-resistant ribosomes has a promoter which is upregulated under the growth-inhibitory conditions in yeast, Candida maltosa.
Biochemical and biophysical research communications 1999;258(3):611-5.
1999: Takai K; Takaku H; Yokoyama S
In vitro codon-reading specificities of unmodified tRNA molecules with different anticodons on the sequence background of Escherichia coli tRNASer.
Biochemical and biophysical research communications 1999;257(3):662-7.
1999: Takai K; Okumura S; Hosono K; Yokoyama S; Takaku H
A single uridine modification at the wobble position of an artificial tRNA enhances wobbling in an Escherichia coli cell-free translation system.
FEBS letters 1999;447(1):1-4.
1999: Habu Y; Takeuchi H; Tamura Y; Miyano-Kurosaki N; Takai K; Takaku H
Development of an HIV-1-dependent expression vector with the Cre/loxP system.
Nucleic acids symposium series 1999;(42):295-6.
1999: Suzuki J; Miyano-Kurosaki N; Takeuchi H; Tamura Y; Kawai G; Takai K; Tanaka Y; Tanaka R; Yamamoto N; Takaku H
Phosphorothioate G3T4G3 motifs inhibits the early stage of HIV-1 infection.
Nucleic acids symposium series 1999;(42):227-8.
1999: Park W S; Miyano-Kurosaki N; Abe T; Takai K; Takaku H
Properties of circular dumbbell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligonucleotides.
Nucleic acids symposium series 1999;(42):225-6.
1999: Kim I; Muto Y; Hosono K; Kitamura A; Watanabe S; Ohtsuki T; Kawai G; Takaku H; Watanabe K; Sakamoto H; Shimura Y; Yokoyama S
NMR signal assignment of the polyuridine tract of the single-stranded RNA complexed with Sxl RBD1-RBD2 by using residue selective [5-(2)H]uridine substitutions.
Nucleic acids symposium series 1999;(42):203-4.
1999: Kitamura A; Muto Y; Watanabe S; Kim I; Ito T; Nishiya Y; Ohtsuki T; Kawai G; Watanabe K; Hosono K; Takaku H; Katoh E; Yamazaki T; Inoue T; Yokoyama S
The guanosine binding mechanism of the Tetrahymena group I intron.
Nucleic acids symposium series 1999;(42):191-2.
1998: Kanda T; Takai K; Yokoyama S; Takaku H
Knocking out a specific tRNA species within unfractionated Escherichia coli tRNA by using antisense (complementary) oligodeoxyribonucleotides.
FEBS letters 1998;440(3):273-6.
1998: Hatta T; Ishikawa M; Takai K; Nakada S; Yokota T; Hata T; Miura K; Takaku H
Inhibition of influenza virus RNA polymerase by 5'-capped short RNA fragments.
Biochemical and biophysical research communications 1998;249(1):103-6.
1998: Yamakawa H; Abe T; Saito T; Takai K; Yamamoto N; Takaku H
Properties of nicked and circular dumbbell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligodeoxynucleotides.
Bioorganic & medicinal chemistry 1998;6(7):1025-32.
1998: Abe T; Suzuki S; Hatta T; Takai K; Yokota T; Takaku H
Specific inhibition of influenza virus RNA polymerase and nucleoprotein gene expression by liposomally encapsulated antisense phosphorothioate oligonucleotides in MDCK cells.
Antiviral chemistry & chemotherapy 1998;9(3):253-62.
1998: Abe T; Takai K; Nakada S; Yokota T; Takaku H
Specific inhibition of influenza virus RNA polymerase and nucleoprotein gene expression by circular dumbbell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligonucleotides.
FEBS letters 1998;425(1):91-6.
1998: Ushijima K; Gouzu H; Hosono K; Shirakawa M; Kagosima K; Takai K; Takaku H
Site-specific cleavage of tRNA by imidazole and/or primary amine groups bound at the 5'-end of oligodeoxyribonucleotides.
Biochimica et biophysica acta 1998;1379(2):217-23.
1998: Abe T; Hatta T; Takai K; Nakashima H; Yokota T; Takaku H
Inhibition of influenza virus replication by phosphorothioate and liposomally endocapsulated oligonucleotides.
Nucleosides & nucleotides 1998;17(1-3):471-8.
1997: Hosono K; Gozu H; Hosaka H; Sakamoto K; Yokoyama S; Takai K; Takaku H
Cleavage effect of oligoribonucleotides substituted at the cleavage sites with modified pyrimidine- and purine-nucleosides.
Biochimica et biophysica acta 1997;1354(3):211-8.
1997: Hatta T; Abe T; Takai K; Takaku H
[Antisense nucleic acid therapy of influenza virus]
Nippon rinsho. Japanese journal of clinical medicine 1997;55(10):2765-71.
1997: Tsukahara S; Suzuki J; Hiratou T; Takai K; Koyanagi Y; Yamamoto N; Takaku H
Inhibition of HIV-1 replication by triple-helix-forming phosphorothioate oligonucleotides targeted to the polypurine tract.
Biochemical and biophysical research communications 1997;233(3):742-7.
1997: Kim I; Muto Y; Inoue M; Watanabe S; Kitamura A; Yokoyama S; Hosono K; Takaku H; Ono A; Kainosho M; Sakamoto H; Shimura Y
NMR analysis of the hydrogen bonding interactions of the RNA-binding domains of the Drosophila sex-lethal protein with target RNA fragments with site-specific [3-15N]uridine substitutions.
Nucleic acids research 1997;25(8):1565-9.
1997: Hatta T; Takai K; Nakada S; Yokota T; Takaku H
Specific inhibition of influenza virus RNA polymerase and nucleoprotein genes expression by liposomally endocapsulated antisense phosphorothioate oligonucleotides: penetration and localization of oligonucleotides in clone 76 cells.
Biochemical and biophysical research communications 1997;232(2):545-9.
1997: Kanda T; Takai K; Yokoyama S; Takaku H
Removing tRNA from a cell-free protein synthesis system for use in protein production.
Nucleic acids symposium series 1997;(37):319-20.
1997: Hiratou T; Tsukahara S; Takai K; Koyanagi Y; Yamamoto N; Takaku H
Inhibition of HIV-1 replication by foldback triple-helix forming oligonucleotides.
Nucleic acids symposium series 1997;(37):221-2.
1997: Abe T; Hatta T; Yamakawa H; Takai K; Yokota T; Takaku H
Synthesis and anti-influenza virus-A activity of circular dumbbell RNA DNA chimeric oligonucleotides.
Nucleic acids symposium series 1997;(37):219-20.
1997: Shirakura H; Hosono K; Kawai G; Takai K; Ohtsuki T; Watanabe K; Sakamoto K; Yokoyama S; Takaku H
Study on site specific cleavage of RNA.
Nucleic acids symposium series 1997;(37):217-8.
1997: Satoh A; Takai K; Yokoyama S; Takaku H
Codon recognition by artificial tRNA molecules with modified nucleosides in the anticodon.
Nucleic acids symposium series 1997;(37):117-8.
1997: Ouchi R; Takai K; Yokoyama S; Takaku H
Codon reading properties of tRNA variants substituted within the anticodon loop.
Nucleic acids symposium series 1997;(37):115-6.
1996: Tsukahara S; Suzuki J; Ushijima K; Takai K; Takaku H
Nonenzymatic sequence-specific cleavage of duplex DNA via triple-helix formation by homopyrimidine phosphorothioate oligonucleotides.
Bioorganic & medicinal chemistry 1996;4(12):2219-24.
1996: Ishibashi T; Yamakawa H; Wang Q; Tsukahara S; Takai K; Maruyama T; Takaku H
Properties of triple helix formation with oligodeoxyribonucleotides containing 8-oxo-2'-deoxyadenosine and 2'-modified nucleoside derivatives.
Bioorganic & medicinal chemistry 1996;4(12):2029-34.
1996: Kuwasaki T; Hosono K; Takai K; Ushijima K; Nakashima H; Saito T; Yamamoto N; Takaku H
Hairpin antisense oligonucleotides containing 2'-methoxynucleosides with base-pairing in the stem region at the 3'-end: penetration, localization, and Anti-HIV activity.
Biochemical and biophysical research communications 1996;228(2):623-31.
1996: Takai K; Takaku H; Yokoyama S
Codon-reading specificity of an unmodified form of Escherichia coli tRNA1Ser in cell-free protein synthesis.
Nucleic acids research 1996;24(15):2894-9.
1996: Hatta T; Nakagawa Y; Takai K; Nakada S; Yokota T; Takaku H
Inhibition of influenza virus RNA polymerase and nucleoprotein genes expression by unmodified, phosphorothioated, and liposomally encapsulated oligonucleotides.
Biochemical and biophysical research communications 1996;223(2):341-6.
1996: Kim S G; Nakashima H; Shoji Y; Inagawa T; Yamamoto N; Kinzuka Y; Takai K; Takaku H
5'-linked lipid-oligodeoxyridonucleotide derivatives as inhibitors of human immunodeficiency virus replication.
Bioorganic & medicinal chemistry 1996;4(4):603-8.
1995: Hosono K; Kuwasaki T; Tsukahara S; Takai K; Takaku H
Properties of base-pairing in the stem region of hairpin antisense oligonucleotides containing 2'-methoxynucleosides.
Biochimica et biophysica acta 1995;1244(2-3):339-44.
1995: Hatta T; Takai K; Yokoyama S; Nakashima H; Yamamoto N; Takaku H
Phosphorothioate oligonucleotides block reverse transcription by the Rnase H activity associated with the HIV-1 polymerase.
Biochemical and biophysical research communications 1995;211(3):1041-6.
1995: Takaku H; Kim S G; Hatta T; Takai K
[Inhibition of gene expression by antisense DNA]
Nippon rinsho. Japanese journal of clinical medicine 1995;53(3):771-8.
1995: Kim S G; Hatta T; Tsukahara S; Nakashima H; Yamamoto N; Shoji Y; Takai K; Takaku H
Antiviral effect of phosphorothioate oligodeoxyribonucleotides complementary to human immunodeficiency virus.
Bioorganic & medicinal chemistry 1995;3(1):49-54.
1995: Okumura S; Takai K; Yokoyama S; Takaku H
Codon recognition by tRNA molecules with a modified or unmodified uridine at the first position of the anticodon.
Nucleic acids symposium series 1995;(34):203-4.
1995: Yamakawa H; Hosono K; Ishibashi T; Takai K; Takaku H
Properties of nicked and circular dumbbell RNA-DNA chimeric oligonucleotides.
Nucleic acids symposium series 1995;(34):133-4.
1995: Hatta T; Nakagawa Y; Takai K; Nakada S; Yokota T; Takaku H
Inhibition of influenza virus RNA polymerase and nucleoprotein of gene expression by antisense oligonucleotides.
Nucleic acids symposium series 1995;(34):129-30.
1995: Ishibashi T; Yamakawa H; Wang Q; Tsukahara S; Takai K; Maruyama T; Takaku H
Triple helix formation with oligodeoxyribonucleotides containing 8-oxo-2'-deoxyadenosine and 2'-modified nucleoside derivatives.
Nucleic acids symposium series 1995;(34):127-8.
1995: Kim I; Watanabe S; Muto Y; Hosono K; Takai K; Takaku H; Kawai G; Watanabe K; Yokoyama S
Selective deuteration of RNA for NMR signal assignment.
Nucleic acids symposium series 1995;(34):123-4.
1994: Wang Q; Tsukahara S; Yamakawa H; Takai K; Takaku H
pH-independent inhibition of restriction endonuclease cleavage via triple helix formation by oligonucleotides containing 8-oxo-2'-deoxyadenosine.
FEBS letters 1994;355(1):11-14.
1994: Hosaka H; Sakabe I; Sakamoto K; Yokoyama S; Takaku H
Sequence-specific cleavage of oligoribonucleotide capable of forming a stem and loop structure.
The Journal of biological chemistry 1994;269(31):20090-4.
1994: Hosaka H; Sakabe I; Sakamoto K; Niimi T; Yokoyama S; Takaku H
Characterization of the secondary structure of an oligonucleotide corresponding to the autocleavage site of a precursor RNA from bacteriophage T4.
Biochimica et biophysica acta 1994;1218(3):351-6.
1994: Takaku H; Hatta T; Tsukahara S
[Inhibition of gene expression by antisense DNA]
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1994;39(8):1466-73.
1993: Tsukahara S; Kim S G; Takaku H
Inhibition of restriction endonuclease cleavage site via triple helix formation by homopyrimidine phosphorothioate oligonucleotides.
Biochemical and biophysical research communications 1993;196(2):990-6.
1993: Hatta T; Kim S G; Nakashima H; Yamamoto N; Sakamoto K; Yokoyama S; Takaku H
Mechanisms of the inhibition of reverse transcription by unmodified and modified antisense oligonucleotides.
FEBS letters 1993;330(2):161-4.
1993: Nagai K; Kanbara K; Nakashima H; Yamamoto N; Suhadolnik R J; Takaku H
Characterization and biological activity of 8-substituted analogues of 2',5'-oligoadenylates.
Biochimica et biophysica acta 1993;1156(3):321-6.
1993: Tanaka H; Hosaka H; Takahashi R; Imamura Y; Takai K; Yokoyama S; Takaku H
Importance of specific purine-pyrimidine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme.
Nucleic acids symposium series 1993;(29):175-6.
1993: Hatta T; Kim S; Yokoyama S; Takaku H
Mechanisms of the inhibition of reverse transcription by unmodified and modified antisense oligonucleotides.
Nucleic acids symposium series 1993;(29):67-8.
1992: Kim S G; Tsukahara S; Yokoyama S; Takaku H
The influence of oligodeoxyribonucleotide phosphorothioate pyrimidine strands on triplex formation.
FEBS letters 1992;314(1):29-32.
1992: Sakatsume O; Tanaka H; Takaku H
Inhibitory effect of oligoribonucleotide phosphorodithioates against the 3'-exonuclease activity.
Nucleic acids symposium series 1992;(27):195-6.
1992: Tsukahara S; Kim S G; Takaku H
The influence of oligodeoxyribonucleotide phosphorothioate pyrimidine strands on triplex stability.
Nucleic acids symposium series 1992;(27):121-2.
1991: Hosaka H; Ogawa T; Sakamoto K; Yokoyama S; Takaku H
Cleavage reaction of a synthetic oligoribonucleotide corresponding to the autocleavage site of a precursor RNA from bacteriophage T4.
FEBS letters 1991;293(1-2):204-6.
1991: Kim S G; Suzuki Y; Nakashima H; Yamamoto N; Takaku H
Phosphorothioate analogues of oligodeoxyribonucleotide: synthesis and activity as inhibitors of replication of human immunodeficiency virus.
Biochemical and biophysical research communications 1991;179(3):1614-9.
1991: Hosaka H; Suzuki Y; Sato H; Gug-Kim S; Takaku H
A convenient approach to the synthesis of medium size oligodeoxyribonucleotides by improved new phosphite method.
Nucleic acids research 1991;19(11):2935-40.
1991: Kanou M; Ohomori H; Nagai K; Yokoyama S; Suhadolnik R J; Sobol R; Takaku H
Purine 8-substitution modulates the ribonuclease L binding and activation abilities of 2',5'-oligoadenylates.
Biochemical and biophysical research communications 1991;176(2):769-74.
1991: Sakatsume O; Hosaka H; Hatta Y; Takaku H
Solid phase synthesis of oligoribonucleotides using 2'-O-1-(2-chloroethoxy) ethyl group for 2'-O-hydroxyl functions.
Nucleic acids symposium series 1991;(25):11-2.
1991: Gug-Kim S; Suzuki Y; Nakashima H; Yamamoto N; Takaku H
Synthesis of antisense oligodeoxyribonucleotides and their anti-HIV activity.
Nucleic acids symposium series 1991;(25):103-4.
1991: Sakatsume O; Yamaguchi T; Takaku H
Solid phase synthesis of mRNA by the phosphoramidite approach using 2'-O-1-(2-chloroethoxy)ethyl protection and its stability in E. coli system.
Nucleic acids symposium series 1991;(24):33-6.
1990: Kanou M; Ohomori H; Takaku H; Yokoyama S; Kawai G; Suhadolnik R J; Sobol R
Chemical synthesis and biological activities of analogues of 2',5'-oligoadenylates containing 8-substituted adenosine derivatives.
Nucleic acids research 1990;18(15):4439-46.
1990: Sakatsume O; Yamane H; Takaku H; Yamamoto N
Use of new phosphonylating and coupling agents in the synthesis of oligodeoxyribonucleotides via the H-phosphonate approach.
Nucleic acids research 1990;18(11):3327-31.
1990: Komatsu H; Ichikawa T; Takaku H; Yokoyama S; Kawai G
Recognition by restriction endodeoxyribonuclease EcoRI of octadeoxyribonucleotides containing modified sugar and base moieties.
Nucleic acids symposium series 1990;(22):95-6.
1990: Sugimoto N; Monden N; Sasaki M; Yamakage S; Takaku H
Thermodynamics and kinetics for the helix formation of the P3 region in Tetrahymena ribozyme.
Nucleic acids symposium series 1990;(22):45-6.
1990: Nagai K; Yokoyama S; Kawai G; Shuhadlnik R J; Takaku H
Synthesis and biological activities of 8-substituted 2-5A analogues.
Nucleic acids symposium series 1990;(22):13-4.
1989: Sakatsume O; Ohtsuki M; Takaku H; Reese C B
Solid phase synthesis of oligoribonucleotides using the 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl (Ctmp) group for the protection of the 2'-hydroxy functions and the H-phosphonate approach.
Nucleic acids research 1989;17(10):3689-97.
1989: Yamakage S; Sakatsume O; Takaku H
Synthesis and properties of the box 9R and 9R' sequences of Tetrahymena rRNA.
Nucleic acids symposium series 1989;(21):81-2.
1988: Yamakage S; Fujii M; Horinouchi Y; Takaku H
(Butylthio)carbonyl group: a new protecting group for the guanine and uracil residues in oligoribonucleotide synthesis.
Nucleic acids symposium series 1988;(19):9-12.

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