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Hiroshi Takaku

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Keijiro Kato; Takashi Senoki; Hiroshi Takaku
Inhibition of HIV-1 replication by RNA with a microRNA-like function.
Hironori Nishitsuji; Reila Sawada; Makoto Abe; Hiroshi Takaku
ZBRK1 represses HIV-1 LTR-mediated transcription.
Kousei Noguchi; Norio Yamamoto; Tomoya Hirano; Manami Hokari; Keisuke Ishibashi; Tomoyuki Kanno; Kaori Miyokawa; Hiroshi Takaku
HIV-1 suppressive sequences are modulated by Rev transport of unspliced RNA and are required for efficient HIV-1 production.

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All Publications

2013: Keijiro Kato; Takashi Senoki; Hiroshi Takaku
Inhibition of HIV-1 replication by RNA with a microRNA-like function.
International journal of molecular medicine 2013;31(1):252-8.
2012: Hironori Nishitsuji; Reila Sawada; Makoto Abe; Hiroshi Takaku
ZBRK1 represses HIV-1 LTR-mediated transcription.
FEBS letters 2012;586(20):3562-8.
2012: Kousei Noguchi; Norio Yamamoto; Tomoya Hirano; Manami Hokari; Keisuke Ishibashi; Tomoyuki Kanno; Kaori Miyokawa; Hiroshi Takaku
HIV-1 suppressive sequences are modulated by Rev transport of unspliced RNA and are required for efficient HIV-1 production.
PloS one 2012;7(12):e51393.
2012: Myint Oo Chang; Tomoyuki Suzuki; Megumi Watanabe; Norio Yamamoto; Hiroshi Takaku
HIV-1 Gag-virus-like particles inhibit HIV-1 replication in dendritic cells and T cells through IFN-α-dependent upregulation of APOBEC3G and 3F.
Journal of innate immunity 2012;4(5-6):579-90.
2011: Hironori Nishitsuji; Hironori Sato; Suguru Yamauchi; Masaru Yokoyama; Hiroshi Takaku
Identification of amino acid residues in HIV-1 reverse transcriptase that are critical for the proteolytic processing of Gag-Pol precursors.
FEBS letters 2011;585(21):3372-7.
2011: Ryuichi Sugiyama; Hironori Nishitsuji; Ayako Furukawa; Masato Katahira; Yuichiro Habu; Hiroaki Takeuchi; Akihide Ryo; Hiroshi Takaku
Heat shock protein 70 inhibits HIV-1 Vif-mediated ubiquitination and degradation of APOBEC3G.
The Journal of biological chemistry 2011;286(12):10051-7.
2011: Kousei Noguchi; Yoshio Ishitu; Hiroshi Takaku
Evaluating target silencing by short hairpin RNA mediated by the group I intron in cultured mammalian cells.
BMC biotechnology 2011;11():79.
2011: Ryuichi Sugiyama; Masaaki Hayafune; Yuichiro Habu; Norio Yamamoto; Hiroshi Takaku
HIV-1 RT-dependent DNAzyme expression inhibits HIV-1 replication without the emergence of escape viruses.
Nucleic acids research 2011;39(2):589-98.
2010: Yuko Shimizu; Takayuki Hishiki; Kazuo Sugiyama; Kazuya Ogawa; Kenji Funami; Atsushi Kato; Yuki Ohsaki; Toyoshi Fujimoto; Hiroshi Takaku; Kunitada Shimotohno
Lipoprotein lipase and hepatic triglyceride lipase reduce the infectivity of hepatitis C virus (HCV) through their catalytic activities on HCV-associated lipoproteins.
Virology 2010;407(1):152-9.
2010: Tomoyuki Suzuki; Myint Oo Chang; Masayuki Kitajima; Hiroshi Takaku
Induction of antitumor immunity against mouse carcinoma by baculovirus-infected dendritic cells.
Cellular & molecular immunology 2010;7(6):440-6.
2010: Takayuki Hishiki; Yuko Shimizu; Reiri Tobita; Kazuo Sugiyama; Kazuya Ogawa; Kenji Funami; Yuki Ohsaki; Toyoshi Fujimoto; Hiroshi Takaku; Takaji Wakita; Thomas F Baumert; Yusuke Miyanari; Kunitada Shimotohno
Infectivity of hepatitis C virus is influenced by association with apolipoprotein E isoforms.
Journal of virology 2010;84(22):12048-57.
2010: Makoto Abe; Hitoshi Suzuki; Hironori Nishitsuji; Hisatoshi Shida; Hiroshi Takaku
Interaction of human T-cell lymphotropic virus type I Rex protein with Dicer suppresses RNAi silencing.
FEBS letters 2010;584(20):4313-8.
2010: Saneyuki Ujino; Saori Yamaguchi; Kunitada Shimotohno; Hiroshi Takaku
Combination therapy for hepatitis C virus with heat-shock protein 90 inhibitor 17-AAG and proteasome inhibitor MG132.
Antiviral chemistry & chemotherapy 2010;20(4):161-7.
2010: Tomoyuki Suzuki; Myint Oo Chang; Masayuki Kitajima; Hiroshi Takaku
Baculovirus activates murine dendritic cells and induces non-specific NK cell and T cell immune responses.
Cellular immunology 2010;262(1):35-43.
2009: Hitoshi Suzuki; Hiroshi Saitoh; Tomoyuki Suzuki; Hiroshi Takaku
Baculovirus-mediated bispecific short-hairpin small-interfering RNAs have remarkable ability to cope with both influenza viruses A and B.
Oligonucleotides 2009;19(4):307-16.
2009: Ryuichi Sugiyama; Yuichiro Habu; Aki Ohnari; Naoko Miyano-Kurosaki; Hiroshi Takaku
RNA interference targeted to the conserved dimerization initiation site (DIS) of HIV-1 restricts virus escape mutation.
Journal of biochemistry 2009;146(4):481-9.
2009: Jacob S Barnor; Yuichiro Habu; Naoki Yamamoto; Naoko Miyano-Kurosaki; Koichi Ishikawa; Naoki Yamamoto; Hiroshi Takaku
Inhibition of HIV-1 replication by long-term treatment with a chimeric RNA containing shRNA and TAR decoy RNA.
Antiviral research 2009;83(2):156-64.
2009: Saneyuki Ujino; Saori Yamaguchi; Kunitada Shimotohno; Hiroshi Takaku
Heat-shock protein 90 is essential for stabilization of the hepatitis C virus nonstructural protein NS3.
The Journal of biological chemistry 2009;284(11):6841-6.
2009: Nazrul Islam Mondal; Hiroshi Takaku; Yasushi Ohkusa; Tamie Sugawara; Nobuhiko Okabe
HIV/AIDS acquisition and transmission in Bangladesh: turning to the concentrated epidemic.
Japanese journal of infectious diseases 2009;62(2):111-9.
2009: Hitoshi Suzuki; Norihiko Matsumoto; Tomoyuki Suzuki; Myint Oo Chang; Hiroshi Takaku
Stable replication of the EBNA1/OriP-mediated baculovirus vector and its application to anti-HCV gene therapy.
Virology journal 2009;6():156.
2009: Hitoshi Suzuki; Hiroshi Saitoh; Tomoyuki Suzuki; Hiroshi Takaku
Inhibition of influenza virus by baculovirus-mediated shRNA.
Nucleic acids symposium series (2004) 2009;(53):287-8.
2009: Nazrul Islam Mondal; Hiroshi Takaku; Yasushi Ohkusa
Impact of age at marriage and migration on HIV and AIDS epidemics in Japan.
International journal for equity in health 2009;8():23.
2008: Reyad A Elbarbary; Hiroshi Takaku; Masayuki Nashimoto
Functional analyses for tRNase Z variants: an aspartate and a histidine in the active site are essential for the catalytic activity.
Biochimica et biophysica acta 2008;1784(12):2079-85.
2008: Hitoshi Suzuki; Nobushige Tamai; Yuichiro Habu; Myint O O Chang; Hiroshi Takaku
Suppression of hepatitis C virus replication by baculovirus vector-mediated short-hairpin RNA expression.
FEBS letters 2008;582(20):3085-9.
2008: Masayuki Takahashi; Hiroshi Takaku; Masayuki Nashimoto
Regulation of the human tRNase ZS gene expression.
FEBS letters 2008;582(17):2532-6.
2008: Y Nishibe; H Kaneko; H Suzuki; T Abe; Y Matsuura; Hiroshi Takaku
Baculovirus-mediated interferon alleviates dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model.
Gene therapy 2008;15(13):990-7.
2008: Tatsuhiko Someya; Kazumi Hosono; Kaori Morimura; Hiroshi Takaku; Gota Kawai
Recognition of a bulged RNA by peptides derived from the influenza NS1 protein.
Journal of biochemistry 2008;143(3):339-47.
2008: Takuma Gondai; Kazuya Yamaguchi; Naoko Miyano-Kurosaki; Yuichirou Habu; Hiroshi Takaku
Short-hairpin RNAs synthesized by T7 phage polymerase do not induce interferon.
Nucleic acids research 2008;36(3):e18.
2008: Masayuki Kitajima; Hiroshi Takaku
Induction of antitumor acquired immunity by baculovirus Autographa californica multiple nuclear polyhedrosis virus infection in mice.
Clinical and vaccine immunology : CVI 2008;15(2):376-8.
2008: Keijiro Kato; Yuichiro Habu; Hiroshi Takaku
Micro RNA like inhibition of HIV-1 replication.
Nucleic acids symposium series (2004) 2008;(52):509-10.
2007: Ryohei Ishii; Asako Minagawa; Hiroshi Takaku; Masamichi Takagi; Masayuki Nashimoto; Shigeyuki Yokoyama
The structure of the flexible arm of Thermotoga maritima tRNase Z differs from those of homologous enzymes.
Acta crystallographica. Section F, Structural biology and crystallization communications 2007;63(Pt 8):637-41.
2007: Hitoshi Suzuki; Hiroyasu Kaneko; Nobushige Tamai; Kunitada Shimotohno; Naoko Miyano-Kurosaki; Hiroshi Takaku
Suppression of hepatitis C virus core protein by short hairpin RNA expression vectors in the core protein expression Huh-7 cells.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):815-20.
2007: Takuma Gondai; Kazuya Yamaguchi; Kahoko Hashimoto; Naoko Miyano-Kurosaki; Hiroshi Takaku
Lack of interferon (IFN) response to T7 Transcribed pppG (n)(n = 2,3)-shRNA.
Nucleosides, nucleotides & nucleic acids 2007;26(6-7):805-8.
2007: Keijiro Kato; Yuichiro Habu; Hiroshi Takaku
Non-sequence specific RNA inhibition of HIV-1 replication.
Nucleic acids symposium series (2004) 2007;(51):411-2.
2007: Kousei Noguchi; Yoshio Ishitu; Naoko Miyano-Kurosaki; Hiroshi Takaku
Expression of shRNA using intron splicing.
Nucleic acids symposium series (2004) 2007;(51):409-10.
2007: A Nakashima; Hiroshi Takaku; Hirotaka S Shibata; Y Negishi; Masamichi Takagi; M Tamura; Masayuki Nashimoto
Gene silencing by the tRNA maturase tRNase ZL under the direction of small-guide RNA.
Gene therapy 2007;14(1):78-85.
2006: Hiroyasu Kaneko; Hitoshi Suzuki; Takashi Abe; Naoko Miyano-Kurosaki; Hiroshi Takaku
Inhibition of HIV-1 replication by vesicular stomatitis virus envelope glycoprotein pseudotyped baculovirus vector-transduced ribozyme in mammalian cells.
Biochemical and biophysical research communications 2006;349(4):1220-7.
2006: Naoko Miyano-Kurosaki; Kunihiko Kurosaki; Michiko Hayashi; Hiroshi Takaku; Masaaki Hayafune; Ken Shirato; Teruhiko Kasuga; Takahiko Endo; Akio Tomoda
2-aminophenoxazine-3-one suppresses the growth of mouse malignant melanoma B16 cells transplanted into C57BL/6Cr Slc mice.
Biological & pharmaceutical bulletin 2006;29(11):2197-201.
2006: Hiroshi Takaku; Ayumi Kimoto; Shoko Kodaira; Masayuki Nashimoto; Masamichi Takagi
Isolation of a Gram-positive poly(3-hydroxybutyrate) (PHB)-degrading bacterium from compost, and cloning and characterization of a gene encoding PHB depolymerase of Bacillus megaterium N-18-25-9.
FEMS microbiology letters 2006;264(2):152-9.
2006: Asako Minagawa; Hiroshi Takaku; Hirotaka S Shibata; Ryohei Ishii; Masamichi Takagi; Shigeyuki Yokoyama; Masayuki Nashimoto
Substrate recognition ability differs among various prokaryotic tRNase Zs.
Biochemical and biophysical research communications 2006;345(1):385-93.
2006: Hiroyuki Hamazaki; Saneyuki Ujino; Naoko Miyano-Kurosaki; Kunitada Shimotohno; Hiroshi Takaku
Inhibition of hepatitis C virus RNA replication by short hairpin RNA synthesized by T7 RNA polymerase in hepatitis C virus subgenomic replicons.
Biochemical and biophysical research communications 2006;343(3):988-94.
2006: Masayuki Kitajima; Hiroyuki Hamazaki; Naoko Miyano-Kurosaki; Hiroshi Takaku
Characterization of baculovirus Autographa californica multiple nuclear polyhedrosis virus infection in mammalian cells.
Biochemical and biophysical research communications 2006;343(2):378-84.
2006: Hirotaka S Shibata; Asako Minagawa; Hiroshi Takaku; Masamichi Takagi; Masayuki Nashimoto
Unstructured RNA is a substrate for tRNase Z.
Biochemistry 2006;45(17):5486-92.
2006: Masaaki Hayafune; Naoko Miyano-Kurosaki; Wee-Sung Park; Yuka Moori; Hiroshi Takaku
Silencing of HIV-1 gene expression by two types of siRNA expression systems.
Antiviral chemistry & chemotherapy 2006;17(5):241-9.
2006: Masaaki Hayafune; Naoko Miyano-Kurosaki; Akiko Kusunoki; Yuka Mouri; Hiroshi Takaku
HIV gene therapy using RNA virus systems.
Nucleic acids symposium series (2004) 2006;(50):79-80.
2006: Asako Minagawa; Hiroshi Takaku; Ryohei Ishii; Masamichi Takagi; Shigeyuki Yokoyama; Masayuki Nashimoto
Identification by Mn2+ rescue of two residues essential for the proton transfer of tRNase Z catalysis.
Nucleic acids research 2006;34(13):3811-8.
2006: Hiroyuki Hamazaki; Hitoshi Takahashi; Kunitada Shimotohno; Naoko Miyano-Kurosaki; Hiroshi Takaku
Inhibition of hcv replication in HCV replicon by shRNAs.
Nucleosides, nucleotides & nucleic acids 2006;25(7):801-5.
2006: Masaaki Hayafune; Naoko Miyano-Kurosaki; Hiroshi Takaku; Wee-Sung Park
Silencing of HIV-1 gene expression by siRNAs in transduced cells.
Nucleosides, nucleotides & nucleic acids 2006;25(7):795-9.
2006: Masahiro Ikeda; Yuichiro Habu; Naoko Miyano-Kurosaki; Hiroshi Takaku
Suppression of HIV-1 replication by a combination of endonucleolytic ribozymes (RNase P and tRNnase ZL).
Nucleosides, nucleotides & nucleic acids 2006;25(4-6):427-37.
2006: Hiroshi Takaku; Shoko Kodaira; Ayumi Kimoto; Masayuki Nashimoto; Masamichi Takagi
Microbial communities in the garbage composting with rice hull as an amendment revealed by culture-dependent and -independent approaches.
Journal of bioscience and bioengineering 2006;101(1):42-50.
2005: Nobukazu Nameki; Tatsuhiko Someya; Satoshi Okano; Reiko Suemasa; Michiko Kimoto; Kyoko Hanawa-Suetsugu; Takaho Terada; Mikako Shirouzu; Ichiro Hirao; Hiroshi Takaku; Hyouta Himeno; Akira Muto; Seiki Kuramitsu; Shigeyuki Yokoyama; Gota Kawai
Interaction analysis between tmRNA and SmpB from Thermus thermophilus.
Journal of biochemistry 2005;138(6):729-39.
2005: Seiki Baba; Ken-ichi Takahashi; Satoko Noguchi; Hiroshi Takaku; Yoshio Koyanagi; Naoki Yamamoto; Gota Kawai
Solution RNA structures of the HIV-1 dimerization initiation site in the kissing-loop and extended-duplex dimers.
Journal of biochemistry 2005;138(5):583-92.
2005: Hirotaka S Shibata; Hiroshi Takaku; Masamichi Takagi; Masayuki Nashimoto
The T loop structure is dispensable for substrate recognition by tRNase ZL.
The Journal of biological chemistry 2005;280(23):22326-34.
2005: Asako Minagawa; Hiroshi Takaku; Masamichi Takagi; Masayuki Nashimoto
The missense mutations in the candidate prostate cancer gene ELAC2 do not alter enzymatic properties of its product.
Cancer letters 2005;222(2):211-5.
2005: Ryohei Ishii; Asako Minagawa; Hiroshi Takaku; Masamichi Takagi; Masayuki Nashimoto; Shigeyuki Yokoyama
Crystal structure of the tRNA 3' processing endoribonuclease tRNase Z from Thermotoga maritima.
The Journal of biological chemistry 2005;280(14):14138-44.
2005: Mieko Hayashi; Emi Satou; Ryouji Ueki; Mayuka Yano; Naoko Miyano-Kurosaki; Masayuki Fujii; Hiroshi Takaku
Resistance to influenza A virus infection by antigen-conjugated CpG oligonucleotides, a novel antigen-specific immunomodulator.
Biochemical and biophysical research communications 2005;329(1):230-6.
2005: Hitoshi Suzuki; Hiroyasu Kaneko; Nobushige Tamai; Naoko Miyano-Kurosaki; Kahoko Hashimoto; Kunitada Shimotohno; Hiroshi Takaku
Suppression of HCV RNA replication by baculovirus-mediated shRNA expression.
Nucleic acids symposium series (2004) 2005;(49):339-40.
2005: Yuichiro Habu; Takashi Nagawa; Norihiko Matsumoto; Hiroaki Takeuchi; Naoko Miyano-Kurosaki; Hiroshi Takaku
Suppression of human immunodeficiency virus type 1 (HIV-1) replication by an HIV-1-dependent double locked vector with the Cre/loxP system.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1907-17.
2005: Jacob Samson Barnor; Naoko Miyano-Kurosaki; Hiroshi Takaku; Kazuya Yamaguchi; Atsushi Sakamoto; Koichi Ishikawa; Naoki Yamamoto; Mubarak Osei-Kwasi; David Ofori-Adjei
The middle to 3' end of the HIV-1 vif gene sequence is important for vif biological activity and could be used for antisense oligonucleotide targets.
Nucleosides, nucleotides & nucleic acids 2005;24(10-12):1745-61.
2005: Masayuki Kitajima; Youichi Tsuyama; Naoko Miyano-Kurosaki; Hiroshi Takaku
Anti-tumor effect of intravenous TNFalpha gene delivery naked plasmid DNA using a hydrodynamics-based procedure.
Nucleosides, nucleotides & nucleic acids 2005;24(5-7):647-50.
2005: Yuichiro Habu; Naoko Miyano-Kurosaki; Michiko Kitano; Yumihiko Endo; Masakazu Yukita; Shigeru Ohira; Hiroshi Takaku; Masayuki Nashimoto; Hiroshi Takaku
Inhibition of HIV-1 gene expression by retroviral vector-mediated small-guide RNAs that direct specific RNA cleavage by tRNase ZL.
Nucleic acids research 2005;33(1):235-43.
2004: Jacob Samson Barnor; Yumihiko Endo; Yuichiro Habu; Naoko Miyano-Kurosaki; Michiko Kitano; Hirokazu Yamamoto; Hiroshi Takaku
Effective inhibition of HIV-1 replication in cultured cells by external guide sequences and ribonuclease P.
Bioorganic & medicinal chemistry letters 2004;14(19):4941-4.
2004: Jacob Samson Barnor; Naoko Miyano-Kurosaki; Kazuya Yamaguchi; Atsushi Sakamoto; Koichi Ishikawa; Yoshio Inagaki; Naoki Yamamoto; Mubarak Osei-Kwasi; David Ofori-Adjei; Hiroshi Takaku
Intracellular expression of antisense RNA transcripts complementary to the human immunodeficiency virus type-1 vif gene inhibits viral replication in infected T-lymphoblastoid cells.
Biochemical and biophysical research communications 2004;320(2):544-50.
2004: Hiroshi Takaku; Eishun Mutoh; Yoshiyuki Sagehashi; Ryouichi Fukuda; Hiroyuki Horiuchi; Kozo Ochi; Masamichi Takagi; Akinori Ohta
A Gcn4p homolog is essential for the induction of a ribosomal protein L41 variant responsible for cycloheximide resistance in the yeast Candida maltosa.
The Journal of biological chemistry 2004;279(22):23030-7.
2004: Asako Minagawa; Hiroshi Takaku; Masamichi Takagi; Masayuki Nashimoto
A novel endonucleolytic mechanism to generate the CCA 3' termini of tRNA molecules in Thermotoga maritima.
The Journal of biological chemistry 2004;279(15):15688-97.
2004: Naoko Miyano-Kurosaki; Jacob Samson Barnor; Hiroaki Takeuchi; Takashi Owada; Hideki Nakashima; Naoki Yamamoto; Tetsuo Matsuzaki; Fumiyuki Shimada; Hiroshi Takaku
In vitro and in vivo transport and delivery of phosphorothioate oligonucleotides with cationic liposomes.
Antiviral chemistry & chemotherapy 2004;15(2):93-100.
2004: Hitoshi Takahashi; Hiroyuki Hamazaki; Yuichiro Habu; Mieko Hayashi; Takayuki Abe; Naoko Miyano-Kurosaki; Hiroshi Takaku
A new modified DNA enzyme that targets influenza virus A mRNA inhibits viral infection in cultured cells.
FEBS letters 2004;560(1-3):69-74.
2004: Hiroyuki Hamazaki; Saneyuki Ujino; Emi Abe; Naoko Miyano-Kurosaki; Kunitada Shimotohno; Hiroshi Takaku
RNAi expression mediated inhibition of HCV replication.
Nucleic acids symposium series (2004) 2004;(48):307-8.
2004: Youichi Tsuyama; Masayuki Kitajima; Naoko Miyano-Kurosaki; Hiroshi Takaku
Anti-tumor effects of naked plasmid DNA using a hydrodynamics-based procedure.
Nucleic acids symposium series (2004) 2004;(48):239-40.
2004: Hiroshi Takaku; Asako Minagawa; Masamichi Takagi; Masayuki Nashimoto
The N-terminal half-domain of the long form of tRNase Z is required for the RNase 65 activity.
Nucleic acids research 2004;32(15):4429-38.
2004: Hiroshi Takaku; Asako Minagawa; Masamichi Takagi; Masayuki Nashimoto
A novel 4-base-recognizing RNA cutter that can remove the single 3' terminal nucleotides from RNA molecules.
Nucleic acids research 2004;32(11):e91.
2003: Seiki Baba; Ken-Ichi Takahashi; Yoshio Koyanagi; Naoki Yamamoto; Hiroshi Takaku; Robert J Gorelick; Gota Kawai
Role of the zinc fingers of HIV-1 nucleocapsid protein in maturation of genomic RNA.
Journal of biochemistry 2003;134(5):637-9.
2003: Wee-Sung Park; Masaaki Hayafune; Naoko Miyano-Kurosaki; Hiroshi Takaku
Specific HIV-1 env gene silencing by small interfering RNAs in human peripheral blood mononuclear cells.
Gene therapy 2003;10(24):2046-50.
2003: Takayuki Abe; Hitoshi Takahashi; Hiroyuki Hamazaki; Naoko Miyano-Kurosaki; Yoshiharu Matsuura; Hiroshi Takaku
Baculovirus induces an innate immune response and confers protection from lethal influenza virus infection in mice.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(3):1133-9.
2003: Hiroshi Takaku; Asako Minagawa; Masamichi Takagi; Masayuki Nashimoto
A candidate prostate cancer susceptibility gene encodes tRNA 3' processing endoribonuclease.
Nucleic acids research 2003;31(9):2272-8.
2003: Tomoyuki Kuwasaki; Masasi Hatta; Hiroaki Takeuchi; Hiroshi Takaku
Inhibition of human immunodeficiency virus 1 replication in vitro by a self-stabilized oligonucleotide with 2'-O-methyl-guanosine-uridine quadruplex motifs.
The Journal of antimicrobial chemotherapy 2003;51(4):813-9.
2003: Kozi Ichiyama; Sei Yokoyama-Kumakura; Yuetsu Tanaka; Reiko Tanaka; Kunitaka Hirose; Kenji Bannai; Takeo Edamatsu; Mikiro Yanaka; Yoshiaki Niitani; Naoko Miyano-Kurosaki; Hiroshi Takaku; Yoshio Koyanagi; Naoki Yamamoto
A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(7):4185-90.
2003: Akiko Kusunoki; Naoko Miyano-Kurosaki; Hiroshi Takaku
A novel single-stranded DNA enzyme expression system using HIV-1 reverse transcriptase.
Biochemical and biophysical research communications 2003;301(2):535-9.
2003: Mieko Hayashi; Makoto Kuwahara; Miwa Ogata; Naoko Miyao-Kurosaki; Takayuki Abel; Ryouji Ueki; Mayuka Yano; Masayuki Fujii; Gunther Hartmann; Hiroshi Takaku
Evaluating the immune responses stimulated by CpG oligodeoxynucleotides.
Nucleic acids research. Supplement (2001) 2003;(3):323-4.
2002: Wee-Sung Park; Naoko Miyano-Kurosaki; Masaaki Hayafune; Emiko Nakajima; Tetsuo Matsuzaki; Fumiyuki Shimada; Hiroshi Takaku
Prevention of HIV-1 infection in human peripheral blood mononuclear cells by specific RNA interference.
Nucleic acids research 2002;30(22):4830-5.
2002: Takubumi Inagawa; Hideki Nakashima; Boleslaw Karwowski; Piotr Guga; Wojciech J Stec; Hiroaki Takeuchi; Hiroshi Takaku
Inhibition of human immunodeficiency virus type 1 replication by P-stereodefined oligo(nucleoside phosphorothioate)s in a long-term infection model.
FEBS letters 2002;528(1-3):48-52.
2002: Yuichiro Habu; Naoko Miyano-Kurosaki; Takashi Nagawa; Norihiko Matsumoto; Hiroaki Takeuchi; Hiroshi Takaku
Inhibition of HIV-1 replication by an HIV-1 dependent ribozyme expression vector with the Cre/loxP (ON/OFF) system.
Antiviral chemistry & chemotherapy 2002;13(5):273-81.
2002: Hiroshi Takaku; Hiroyuki Horiuchi; Masamichi Takagi; Akinori Ohta
Pseudohyphal growth in a dimorphic yeast, Candida maltosa, after disruption of the C-GCN4 gene, a homolog of Saccharomyces cerevisiae GCN4.
Bioscience, biotechnology, and biochemistry 2002;66(9):1936-9.
2002: Aya Kitamura; Yutaka Muto; Satoru Watanabe; Insil Kim; Takuhiro Ito; Yoichi Nishiya; Kensaku Sakamoto; Takashi Ohtsuki; Gota Kawai; Kimitsuna Watanabe; Kazumi Hosono; Hiroshi Takaku; Etsuko Katoh; Toshimasa Yamazaki; Tan Inoue; Shigeyuki Yokoyama
Solution structure of an RNA fragment with the P7/P9.0 region and the 3'-terminal guanosine of the tetrahymena group I intron.
RNA (New York, N.Y.) 2002;8(4):440-51.
2002: Jun-ichiro Suzuki; Naoko Miyano-Kurosaki; Tomoyuki Kuwasaki; Hiroaki Takeuchi; Gota Kawai; Hiroshi Takaku
Inhibition of human immunodeficiency virus type 1 activity in vitro by a new self-stabilized oligonucleotide with guanosine-thymidine quadruplex motifs.
Journal of virology 2002;76(6):3015-22.
2002: Masakazu Yukita; Michiko Kitano; Naoko Miyano-Kurosaki; Hiroaki Takeuchi; Masayuki Nashimoto; Hiroshi Takaku
RNA cleavage by a mammalian tRNA 3'processing endoribonuclease (3'tRNase) reduces HIV-1 expression.
Nucleic acids research. Supplement (2001) 2002;(2):297-8.
2002: Takashi Nagawa; Yuichiro Habu; Norihiko Matsumoto; Hiroaki Takeuchi; Naoko Kurosaki; Hiroshi Takaku
Development of HIV-1 dependent gene expression vector with the Cre/loxP (ON) system.
Nucleic acids research. Supplement (2001) 2002;(2):295-6.
2002: Jacob Samson Barnor; Naoko Miyano-Kurosaki; Kazuya Yamaguchi; Hiroki Kobayashi; Koichi Ishikawa; Mubarak Osei-Kwasi; William Kwabina Ampofo; David Ofori-Adjei; Yoshio Inagaki; Naoki Yamamoto; Hiroshi Takaku
Down regulation of human immunodeficiency virus type-1 (HIV-1) expression by Vif antisense RNA expression vectors in transfected cells.
Nucleic acids research. Supplement (2001) 2002;(2):123-4.
2001: M Tado; T Abe; T Hatta; M Ishikawa; S Nakada; T Yokota; Hiroshi Takaku
Inhibitory effect of modified 5'-capped short RNA fragments on influenza virus RNA polymerase gene expression.
Antiviral chemistry & chemotherapy 2001;12(6):353-8.
2001: K Takahashi ; S Baba; Y Koyanagi; N Yamamoto; Hiroshi Takaku; Gota Kawai
Two basic regions of NCp7 are sufficient for conformational conversion of HIV-1 dimerization initiation site from kissing-loop dimer to extended-duplex dimer.
The Journal of biological chemistry 2001;276(33):31274-8.
2001: K Ushijima; M Shirakawa; K Kagoshima; W S Park; Naoko Miyano-Kurosaki; Hiroshi Takaku
Anti-HIV-1 activity of an antisense phosphorothioate oligonucleotide bearing imidazole and primary amine groups.
Bioorganic & medicinal chemistry 2001;9(8):2165-9.
2001: Hiroshi Takaku; Eishun Mutoh; Hiroyuki Horiuchi; Akinori Ohta; Masamichi Takagi
Ray38p, a homolog of a purine motif triple-helical DNA-binding protein, Stm1p, is a ribosome-associated protein and dissociated from ribosomes prior to the induction of cycloheximide resistance in Candida maltosa.
Biochemical and biophysical research communications 2001;284(1):194-202.
2001: Yuichiro Habu; Naoko Miyano-Kurosaki; Hiroaki Takeuchi; Norihiko Matsumoto; Y Tamura; Hiroshi Takaku
Inhibition of HIV-1 replication by the Cre-loxP hammerhead ribozyme.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):723-6.
2001: Michiko Kitano; Jacob Samson Barnor; Naoko Miyano-Kurosaki; Yumihiko Endo; Masakazu Yukita; Hiroaki Takeuchi; Y Tamura; K Takai; Masayuki Nashimoto; Hiroshi Takaku
Effective suppression of HIV-1 gene expression by a mammalian tRNA 3' processing endoribonuclease and external guide sequence oligozymes.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):719-22.
2001: T Hiratou; Naoko Miyano-Kurosaki; H Gushima; Hiroshi Takaku
A new class of anti-HIV-1 oligonucleotide targeted to the polypurine tract of viral RNA.
Nucleosides, nucleotides & nucleic acids 2001;20(4-7):715-8.
2001: T Abe; T Mizuta; T Hatta; Naoko Miyano-Kurosaki; M Fujiwara; K Takai; S Shigeta; T Yokota; Hiroshi Takaku
Antisense therapy of influenza.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;13(1):61-9.
2001: Akiko Kusunoki; T Saitou; Naoko Miyano-Kurosaki; Hiroshi Takaku
Inhibition of the human chemokine receptor CXCR4 by antisense phosphorothioate oligodeoxyribonucleotides.
FEBS letters 2001;488(1-2):64-8.
2001: Wee-Sung Park; Naoko Miyano-Kurosaki; E Nakajima; Hiroshi Takaku
Specific inhibition of HIV-1 gene expression by double-stranded RNA.
Nucleic acids research. Supplement (2001) 2001;(1):219-20.
2001: Y Endo; Naoko Miyano-Kurosaki; M Kitano; Y Habu; Hiroshi Takaku
Effective inhibition of HIV-1 replication in cultured cells by external guide sequences and ribonuclease.
Nucleic acids research. Supplement (2001) 2001;(1):213-4.
2001: Seiki Baba; K Takahashi; Y Nomura; S Noguchi; Y Koyanagi; Naoki Yamamoto; Hiroshi Takaku; Gota Kawai
Conformational change of dimerization initiation site of HIV-1 genomic RNA by NCp7 or heat treatment.
Nucleic acids research. Supplement (2001) 2001;(1):155-6.
2001: H Nishitsuji; Y Tamura; T Fuse; Y Habu; Naoko Miyano-Kurosaki; Hiroshi Takaku
Inhibition of HIV-1 replication by 5'LTR decoy RNA.
Nucleic acids research. Supplement (2001) 2001;(1):141-2.
2000: T Abe; Hiroshi Takaku
[Protection against influenza by genetically engineered vaccines].
Nihon rinsho. Japanese journal of clinical medicine 2000;58(11):2313-20.
2000: H Hosaka; Kazumi Hosono; Gota Kawai; K Takai; Hiroshi Takaku
Self-cleavage of p2Sp1 RNA with Mg2+ and non-ionic detergent (Brij 58).
Journal of inorganic biochemistry 2000;82(1-4):215-9.
2000: T Hiratou; S Tsukahara; Naoko Miyano-Kurosaki; K Takai; T Saito; Naoki Yamamoto; Hiroshi Takaku
Anti-HIV-1 activity by a triple-helix forming oligonucleotides targeted to polypurine tract on viral RNA.
Nucleosides, nucleotides & nucleic acids 2000;19(10-12):1721-34.
2000: Akiko Kusunoki; Naoko Miyano-Kurosaki; T Kimura; K Takai; Naoki Yamamoto; H Gushima; Hiroshi Takaku
Antisense phosphorothioate oligonucleotides targeted to the human chemokine receptor CXCR4.
Nucleosides, nucleotides & nucleic acids 2000;19(10-12):1709-19.
2000: Insil Kim; Yutaka Muto; Satoru Watanabe; Aya Kitamura; Yasuhiro Futamura; Shigeyuki Yokoyama; Kazumi Hosono; Gota Kawai; Hiroshi Takaku; N Dohmae; K Takio; H Saskamoto; Yoshiro Shimura
Interactions of a didomain fragment of the Drosophila sex-lethal protein with single-stranded uridine-rich oligoribonucleotides derived from the transformer and Sex-lethal messenger RNA precursors: NMR with residue-selective [5-2H]uridine substitutions.
Journal of biomolecular NMR 2000;17(2):153-65.
2000: A Satoh; K Takai; R Ouchi; Shigeyuki Yokoyama; Hiroshi Takaku
Effects of anticodon 2'-O-methylations on tRNA codon recognition in an Escherichia coli cell-free translation.
RNA (New York, N.Y.) 2000;6(5):680-6.
2000: T Kanda; K Takai; Takahiro Hohsaka; Masahiko Sisido; Hiroshi Takaku
Sense codon-dependent introduction of unnatural amino acids into multiple sites of a protein.
Biochemical and biophysical research communications 2000;270(3):1136-9.
2000: Y Tamura; M Tao; Naoko Miyano-Kurosaki; K Takai; Hiroshi Takaku
Inhibition of human telomerase activity by antisense phosphorothioate oligonucleotides encapsulated with the transfection reagent, FuGENE6, in HeLa cells.
Antisense & nucleic acid drug development 2000;10(2):87-96.
2000: K Takahashi; S Baba; Y Hayashi; Y Koyanagi; Naoki Yamamoto; Hiroshi Takaku; Gota Kawai
NMR analysis of intra- and inter-molecular stems in the dimerization initiation site of the HIV-1 genome.
Journal of biochemistry 2000;127(4):681-6.
2000: T Kanda; K Takai; Shigeyuki Yokoyama; Hiroshi Takaku
Specific inactivation of Escherichia coli tRNA(Phe) by antisense DNA-treatment under Mg2+-deficient conditions.
Bioorganic & medicinal chemistry 2000;8(3):675-9.
2000: T Hiratou; Naoko Miyano-Kurosaki; S Tsukahara; Y Tamura; K Takai; Naoki Yamamoto; Hiroshi Takaku
Anti-human immunodeficiency virus type 1 of a two-strand-system targeted to the polypurine tract.
International journal of molecular medicine 2000;5(2):125-32.
2000: H Takahashi; T Abe; K Takai; Hiroshi Takaku
Inhibition of influenza virus RNA (PB2 mRNA) expression by a modified DNA enzyme.
Nucleic acids symposium series 2000;(44):287-8.
2000: Michiko Kitano; Naoko Miyano-Kurosaki; Yumihiko Endo; Masakazu Yukita; Hiroaki Takeuchi; Y Tamura; K Takai; Masayuki Nashimoto; Hiroshi Takaku
Effective suppression of HIV-1 gene expression by a mammalian tRNA 3' processing endoribonuclease and external guide sequence oligozymes.
Nucleic acids symposium series 2000;(44):207-8.
2000: Y Tamura; M Yoshida; Jun-ichiro Suzuki; T Hiratou; Naoko Miyano-Kurosaki; K Takai; Hiroshi Takaku
Properties of quadruplex oligonucleotides with anti-HIV-1 activity.
Nucleic acids symposium series 2000;(44):181-2.
2000: T Kanda; K Takai; Shigeyuki Yokoyama; Hiroshi Takaku
An easy cell-free protein synthesis system dependent on the addition of crude Escherichia coli tRNA.
Journal of biochemistry 2000;127(1):37-41.
2000: K I Takahashi; S Baba; P Chattopadhyay; Y Koyanagi; N Yamamoto; Hiroshi Takaku; Gota Kawai
Structural requirement for the two-step dimerization of human immunodeficiency virus type 1 genome.
RNA (New York, N.Y.) 2000;6(1):96-102.
1999: Kazumi Hosono; H Hosaka; Gota Kawai; K Takai; Hiroshi Takaku
The stem hairpin loop structure of p2Sp1 RNA is required for RNA-cleaving activity.
Biochimica et biophysica acta 1999;1489(2-3):374-82.
1999: T Hosoya; Hiroaki Takeuchi; Y Kanesaka; H Yamakawa; Naoko Miyano-Kurosaki; K Takai; Naoki Yamamoto; Hiroshi Takaku
Sequence-specific inhibition of a transcription factor by circular dumbbell DNA oligonucleotides.
FEBS letters 1999;461(3):136-40.
1999: P Kumar; Hiroshi Takaku
Properties of mixed backbone oligonucleotides containing 3'-O-methyl ribonucleosides.
Bioorganic & medicinal chemistry letters 1999;9(17):2515-20.
1999: T Hiratou; S Tsukahara; Naoko Miyano-Kurosaki; K Takai; Naoki Yamamoto; Hiroshi Takaku
Inhibition of HIV-1 replication by a two-strand system (FTFOs) targeted to the polypurine tract.
FEBS letters 1999;456(1):186-90.
1999: M Tao; Naoko Miyano-Kurosaki; K Takai; Hiroshi Takaku
Specific inhibition of human telomerase activity by transfection reagent, FuGENE6-antisense phosphorothioate oligonucleotide complex in HeLa cells.
FEBS letters 1999;454(3):312-6.
1999: Akiko Kusunoki; A Wada; N Kurosaki; T Kimura; K Takai; Naoki Yamamoto; Hiroshi Takaku
Antisense oligodeoxynucleotide complementary to CXCR4 mRNA block replication of HIV-1 in COS cells.
Nucleosides & nucleotides 1999;18(6-7):1705-8.
1999: T Abe; T Mizuta; S Suzuki; T Hatta; K Takai; T Yokota; Hiroshi Takaku
In vitro and in vivo anti-influenza A virus activity of antisense oligonucleotides.
Nucleosides & nucleotides 1999;18(6-7):1685-8.
1999: T Mizuta; M Fujiwara; T Hatta; T Abe; Naoko Miyano-Kurosaki; S Shigeta; T Yokota; Hiroshi Takaku
Antisense oligonucleotides directed against the viral RNA polymerase gene enhance survival of mice infected with influenza A.
Nature biotechnology 1999;17(6):583-7.
1999: Eishun Mutoh; Hiroshi Takaku; Akinori Ohta; Masamichi Takagi
A gene coding for a ribosomal protein L41 in cycloheximide-resistant ribosomes has a promoter which is upregulated under the growth-inhibitory conditions in yeast, Candida maltosa.
Biochemical and biophysical research communications 1999;258(3):611-5.
1999: K Ushijima; T Ishibashi; H Yamakawa; S Tsukahara; K Takai; T Maruyama; Hiroshi Takaku
Inhibition of restriction endonuclease cleavage by triple helix formation with RNA and 2'-O-methyl RNA oligonucleotides containing 8-oxo-adenosine in place of cytidine.
Biochemistry 1999;38(20):6570-5.
1999: K Takai; Hiroshi Takaku; Shigeyuki Yokoyama
In vitro codon-reading specificities of unmodified tRNA molecules with different anticodons on the sequence background of Escherichia coli tRNASer.
Biochemical and biophysical research communications 1999;257(3):662-7.
1999: K Takai; S Okumura; Kazumi Hosono; Shigeyuki Yokoyama; Hiroshi Takaku
A single uridine modification at the wobble position of an artificial tRNA enhances wobbling in an Escherichia coli cell-free translation system.
FEBS letters 1999;447(1):1-4.
1999: Yuichiro Habu; Hiroaki Takeuchi; Y Tamura; Naoko Miyano-Kurosaki; K Takai; Hiroshi Takaku
Development of an HIV-1-dependent expression vector with the Cre/loxP system.
Nucleic acids symposium series 1999;(42):295-6.
1999: Jun-ichiro Suzuki; Naoko Miyano-Kurosaki; Hiroaki Takeuchi; Y Tamura; Gota Kawai; K Takai; Y Tanaka; R Tanaka; Naoki Yamamoto; Hiroshi Takaku
Phosphorothioate G3T4G3 motifs inhibits the early stage of HIV-1 infection.
Nucleic acids symposium series 1999;(42):227-8.
1999: W S Park; Naoko Miyano-Kurosaki; T Abe; K Takai; Hiroshi Takaku
Properties of circular dumbbell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligonucleotides.
Nucleic acids symposium series 1999;(42):225-6.
1999: Insil Kim; Yutaka Muto; Kazumi Hosono; Aya Kitamura; Satoru Watanabe; Takashi Ohtsuki; Gota Kawai; Hiroshi Takaku; Kunitomo Watanabe; H Sakamoto; Yoshiro Shimura; Shigeyuki Yokoyama
NMR signal assignment of the polyuridine tract of the single-stranded RNA complexed with Sxl RBD1-RBD2 by using residue selective [5-(2)H]uridine substitutions.
Nucleic acids symposium series 1999;(42):203-4.
1999: Aya Kitamura; Yutaka Muto; Satoru Watanabe; Insil Kim; Takuhiro Ito; Y Nishiya; Takashi Ohtsuki; Gota Kawai; Kunitomo Watanabe; Kazumi Hosono; Hiroshi Takaku; Etsuko Katoh; T Yamazaki; T Inoue; Shigeyuki Yokoyama
The guanosine binding mechanism of the Tetrahymena group I intron.
Nucleic acids symposium series 1999;(42):191-2.
1998: T Kanda; K Takai; Shigeyuki Yokoyama; Hiroshi Takaku
Knocking out a specific tRNA species within unfractionated Escherichia coli tRNA by using antisense (complementary) oligodeoxyribonucleotides.
FEBS letters 1998;440(3):273-6.
1998: T Hatta; M Ishikawa; K Takai; S Nakada; T Yokota; T Hata; K Miura; Hiroshi Takaku
Inhibition of influenza virus RNA polymerase by 5'-capped short RNA fragments.
Biochemical and biophysical research communications 1998;249(1):103-6.
1998: H Yamakawa; T Abe; T Saito; K Takai; N Yamamoto; Hiroshi Takaku
Properties of nicked and circular dumbbell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligodeoxynucleotides.
Bioorganic & medicinal chemistry 1998;6(7):1025-32.
1998: T Abe; S Suzuki; T Hatta; K Takai; T Yokota; Hiroshi Takaku
Specific inhibition of influenza virus RNA polymerase and nucleoprotein gene expression by liposomally encapsulated antisense phosphorothioate oligonucleotides in MDCK cells.
Antiviral chemistry & chemotherapy 1998;9(3):253-62.
1998: T Abe; K Takai; S Nakada; T Yokota; Hiroshi Takaku
Specific inhibition of influenza virus RNA polymerase and nucleoprotein gene expression by circular dumbbell RNA/DNA chimeric oligonucleotides containing antisense phosphodiester oligonucleotides.
FEBS letters 1998;425(1):91-6.
1998: K Ushijima; H Gouzu; Kazumi Hosono; M Shirakawa; K Kagosima; K Takai; Hiroshi Takaku
Site-specific cleavage of tRNA by imidazole and/or primary amine groups bound at the 5'-end of oligodeoxyribonucleotides.
Biochimica et biophysica acta 1998;1379(2):217-23.
1998: T Abe; T Hatta; K Takai; H Nakashima; T Yokota; Hiroshi Takaku
Inhibition of influenza virus replication by phosphorothioate and liposomally endocapsulated oligonucleotides.
Nucleosides & nucleotides 1998;17(1-3):471-8.
1997: Kazumi Hosono; H Gozu; H Hosaka; Kensaku Sakamoto; Shigeyuki Yokoyama; K Takai; Hiroshi Takaku
Cleavage effect of oligoribonucleotides substituted at the cleavage sites with modified pyrimidine- and purine-nucleosides.
Biochimica et biophysica acta 1997;1354(3):211-8.
1997: T Hatta; T Abe; K Takai; Hiroshi Takaku
[Antisense nucleic acid therapy of influenza virus].
Nihon rinsho. Japanese journal of clinical medicine 1997;55(10):2765-71.
1997: S Tsukahara; Jun-ichiro Suzuki; T Hiratou; K Takai; Y Koyanagi; Naoki Yamamoto; Hiroshi Takaku
Inhibition of HIV-1 replication by triple-helix-forming phosphorothioate oligonucleotides targeted to the polypurine tract.
Biochemical and biophysical research communications 1997;233(3):742-7.
1997: Insil Kim; Yutaka Muto; M Inoue; Satoru Watanabe; Aya Kitamura; Shigeyuki Yokoyama; Kazumi Hosono; Hiroshi Takaku; A Ono; M Kainosho; H Sakamoto; Yoshiro Shimura
NMR analysis of the hydrogen bonding interactions of the RNA-binding domains of the Drosophila sex-lethal protein with target RNA fragments with site-specific [3-15N]uridine substitutions.
Nucleic acids research 1997;25(8):1565-9.
1997: T Hatta; K Takai; S Nakada; T Yokota; Hiroshi Takaku
Specific inhibition of influenza virus RNA polymerase and nucleoprotein genes expression by liposomally endocapsulated antisense phosphorothioate oligonucleotides: penetration and localization of oligonucleotides in clone 76 cells.
Biochemical and biophysical research communications 1997;232(2):545-9.
1997: T Kanda; K Takai; Shigeyuki Yokoyama; Hiroshi Takaku
Removing tRNA from a cell-free protein synthesis system for use in protein production.
Nucleic acids symposium series 1997;(37):319-20.
1997: T Hiratou; S Tsukahara; K Takai; Y Koyanagi; Naoki Yamamoto; Hiroshi Takaku
Inhibition of HIV-1 replication by foldback triple-helix forming oligonucleotides.
Nucleic acids symposium series 1997;(37):221-2.
1997: T Abe; T Hatta; H Yamakawa; K Takai; T Yokota; Hiroshi Takaku
Synthesis and anti-influenza virus-A activity of circular dumbbell RNA DNA chimeric oligonucleotides.
Nucleic acids symposium series 1997;(37):219-20.
1997: H Shirakura; Kazumi Hosono; Gota Kawai; K Takai; Takashi Ohtsuki; Kunitomo Watanabe; Kensaku Sakamoto; Shigeyuki Yokoyama; Hiroshi Takaku
Study on site specific cleavage of RNA.
Nucleic acids symposium series 1997;(37):217-8.
1997: A Satoh; K Takai; Shigeyuki Yokoyama; Hiroshi Takaku
Codon recognition by artificial tRNA molecules with modified nucleosides in the anticodon.
Nucleic acids symposium series 1997;(37):117-8.
1997: R Ouchi; K Takai; Shigeyuki Yokoyama; Hiroshi Takaku
Codon reading properties of tRNA variants substituted within the anticodon loop.
Nucleic acids symposium series 1997;(37):115-6.
1996: S Tsukahara; J Suzuki; K Ushijima; K Takai; Hiroshi Takaku
Nonenzymatic sequence-specific cleavage of duplex DNA via triple-helix formation by homopyrimidine phosphorothioate oligonucleotides.
Bioorganic & medicinal chemistry 1996;4(12):2219-24.
1996: T Ishibashi; H Yamakawa; Q Wang; S Tsukahara; K Takai; T Maruyama; Hiroshi Takaku
Properties of triple helix formation with oligodeoxyribonucleotides containing 8-oxo-2'-deoxyadenosine and 2'-modified nucleoside derivatives.
Bioorganic & medicinal chemistry 1996;4(12):2029-34.
1996: T Kuwasaki; Kazumi Hosono; K Takai; K Ushijima; H Nakashima; T Saito; Naoki Yamamoto; Hiroshi Takaku
Hairpin antisense oligonucleotides containing 2'-methoxynucleosides with base-pairing in the stem region at the 3'-end: penetration, localization, and Anti-HIV activity.
Biochemical and biophysical research communications 1996;228(2):623-31.
1996: K Takai; Hiroshi Takaku; Shigeyuki Yokoyama
Codon-reading specificity of an unmodified form of Escherichia coli tRNA1Ser in cell-free protein synthesis.
Nucleic acids research 1996;24(15):2894-9.
1996: T Hatta; Y Nakagawa; K Takai; S Nakada; T Yokota; Hiroshi Takaku
Inhibition of influenza virus RNA polymerase and nucleoprotein genes expression by unmodified, phosphorothioated, and liposomally encapsulated oligonucleotides.
Biochemical and biophysical research communications 1996;223(2):341-6.
1996: S G Kim; H Nakashima; Y Shoji; T Inagawa; Naoki Yamamoto; Y Kinzuka; K Takai; Hiroshi Takaku
5'-linked lipid-oligodeoxyridonucleotide derivatives as inhibitors of human immunodeficiency virus replication.
Bioorganic & medicinal chemistry 1996;4(4):603-8.
1995: T Hatta; K Takai; Shigeyuki Yokoyama; H Nakashima; Naoki Yamamoto; Hiroshi Takaku
Phosphorothioate oligonucleotides block reverse transcription by the Rnase H activity associated with the HIV-1 polymerase.
Biochemical and biophysical research communications 1995;211(3):1041-6.
1995: Kazumi Hosono; T Kuwasaki; S Tsukahara; K Takai; Hiroshi Takaku
Properties of base-pairing in the stem region of hairpin antisense oligonucleotides containing 2'-methoxynucleosides.
Biochimica et biophysica acta 1995;1244(2-3):339-44.
1995: Hiroshi Takaku; S G Kim; T Hatta; K Takai
[Inhibition of gene expression by antisense DNA].
Nihon rinsho. Japanese journal of clinical medicine 1995;53(3):771-8.
1995: S Okumura; K Takai; Shigeyuki Yokoyama; Hiroshi Takaku
Codon recognition by tRNA molecules with a modified or unmodified uridine at the first position of the anticodon.
Nucleic acids symposium series 1995;(34):203-4.
1995: H Yamakawa; Kazumi Hosono; T Ishibashi; K Takai; Hiroshi Takaku
Properties of nicked and circular dumbbell RNA-DNA chimeric oligonucleotides.
Nucleic acids symposium series 1995;(34):133-4.
1995: T Hatta; Y Nakagawa; K Takai; S Nakada; T Yokota; Hiroshi Takaku
Inhibition of influenza virus RNA polymerase and nucleoprotein of gene expression by antisense oligonucleotides.
Nucleic acids symposium series 1995;(34):129-30.
1995: T Ishibashi; H Yamakawa; Q Wang; S Tsukahara; K Takai; T Maruyama; Hiroshi Takaku
Triple helix formation with oligodeoxyribonucleotides containing 8-oxo-2'-deoxyadenosine and 2'-modified nucleoside derivatives.
Nucleic acids symposium series 1995;(34):127-8.
1995: Insil Kim; Satoru Watanabe; Yutaka Muto; Kazumi Hosono; K Takai; Hiroshi Takaku; Gota Kawai; K Watanabe; Shigeyuki Yokoyama
Selective deuteration of RNA for NMR signal assignment.
Nucleic acids symposium series 1995;(34):123-4.
1995: S G Kim; T Hatta; S Tsukahara; H Nakashima; Naoki Yamamoto; Y Shoji; K Takai; Hiroshi Takaku
Antiviral effect of phosphorothioate oligodeoxyribonucleotides complementary to human immunodeficiency virus.
Bioorganic & medicinal chemistry 1995;3(1):49-54.
1994: Q Wang; S Tsukahara; H Yamakawa; K Takai; Hiroshi Takaku
pH-independent inhibition of restriction endonuclease cleavage via triple helix formation by oligonucleotides containing 8-oxo-2'-deoxyadenosine.
FEBS letters 1994;355(1):11-14.
1994: H Hosaka; I Sakabe; Kensaku Sakamoto; Shigeyuki Yokoyama; Hiroshi Takaku
Sequence-specific cleavage of oligoribonucleotide capable of forming a stem and loop structure.
The Journal of biological chemistry 1994;269(31):20090-4.
1994: H Hosaka; I Sakabe; Kensaku Sakamoto; T Niimi; Shigeyuki Yokoyama; Hiroshi Takaku
Characterization of the secondary structure of an oligonucleotide corresponding to the autocleavage site of a precursor RNA from bacteriophage T4.
Biochimica et biophysica acta 1994;1218(3):351-6.
1994: Hiroshi Takaku; T Hatta; S Tsukahara
[Inhibition of gene expression by antisense DNA].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1994;39(8):1466-73.
1993: S Tsukahara; S G Kim; Hiroshi Takaku
Inhibition of restriction endonuclease cleavage site via triple helix formation by homopyrimidine phosphorothioate oligonucleotides.
Biochemical and biophysical research communications 1993;196(2):990-6.
1993: T Hatta; S G Kim; H Nakashima; Naoki Yamamoto; Kensaku Sakamoto; Shigeyuki Yokoyama; Hiroshi Takaku
Mechanisms of the inhibition of reverse transcription by unmodified and modified antisense oligonucleotides.
FEBS letters 1993;330(2):161-4.
1993: K Nagai; K Kanbara; H Nakashima; N Yamamoto; R J Suhadolnik; Hiroshi Takaku
Characterization and biological activity of 8-substituted analogues of 2',5'-oligoadenylates.
Biochimica et biophysica acta 1993;1156(3):321-6.
1993: H Tanaka; H Hosaka; R Takahashi; Y Imamura; K Takai; Shigeyuki Yokoyama; Hiroshi Takaku
Importance of specific purine-pyrimidine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme.
Nucleic acids symposium series 1993;(29):175-6.
1993: T Hatta; S Kim; Shigeyuki Yokoyama; Hiroshi Takaku
Mechanisms of the inhibition of reverse transcription by unmodified and modified antisense oligonucleotides.
Nucleic acids symposium series 1993;(29):67-8.
1992: S G Kim; S Tsukahara; Shigeyuki Yokoyama; Hiroshi Takaku
The influence of oligodeoxyribonucleotide phosphorothioate pyrimidine strands on triplex formation.
FEBS letters 1992;314(1):29-32.
1992: O Sakatsume; H Tanaka; Hiroshi Takaku
Inhibitory effect of oligoribonucleotide phosphorodithioates against the 3'-exonuclease activity.
Nucleic acids symposium series 1992;(27):195-6.
1992: S Tsukahara; S G Kim; Hiroshi Takaku
The influence of oligodeoxyribonucleotide phosphorothioate pyrimidine strands on triplex stability.
Nucleic acids symposium series 1992;(27):121-2.
1991: H Hosaka; T Ogawa; Kensaku Sakamoto; Shigeyuki Yokoyama; Hiroshi Takaku
Cleavage reaction of a synthetic oligoribonucleotide corresponding to the autocleavage site of a precursor RNA from bacteriophage T4.
FEBS letters 1991;293(1-2):204-6.
1991: S G Kim; Y Suzuki; H Nakashima; Naoki Yamamoto; Hiroshi Takaku
Phosphorothioate analogues of oligodeoxyribonucleotide: synthesis and activity as inhibitors of replication of human immunodeficiency virus.
Biochemical and biophysical research communications 1991;179(3):1614-9.
1991: H Hosaka; Y Suzuki; H Sato; S Gug-Kim; Hiroshi Takaku
A convenient approach to the synthesis of medium size oligodeoxyribonucleotides by improved new phosphite method.
Nucleic acids research 1991;19(11):2935-40.
1991: M Kanou; H Ohomori; K Nagai; Shigeyuki Yokoyama; R J Suhadolnik; Robert W Sobol; Hiroshi Takaku
Purine 8-substitution modulates the ribonuclease L binding and activation abilities of 2',5'-oligoadenylates.
Biochemical and biophysical research communications 1991;176(2):769-74.
1991: O Sakatsume; H Hosaka; Y Hatta; Hiroshi Takaku
Solid phase synthesis of oligoribonucleotides using 2'-O-1-(2-chloroethoxy) ethyl group for 2'-O-hydroxyl functions.
Nucleic acids symposium series 1991;(25):11-2.
1991: S Gug-Kim; Y Suzuki; H Nakashima; Naoki Yamamoto; Hiroshi Takaku
Synthesis of antisense oligodeoxyribonucleotides and their anti-HIV activity.
Nucleic acids symposium series 1991;(25):103-4.
1991: O Sakatsume; T Yamaguchi; Hiroshi Takaku
Solid phase synthesis of mRNA by the phosphoramidite approach using 2'-O-1-(2-chloroethoxy)ethyl protection and its stability in E. coli system.
Nucleic acids symposium series 1991;(24):33-6.
1990: M Kanou; H Ohomori; Hiroshi Takaku; Shigeyuki Yokoyama; Gota Kawai; R J Suhadolnik; R Sobol
Chemical synthesis and biological activities of analogues of 2',5'-oligoadenylates containing 8-substituted adenosine derivatives.
Nucleic acids research 1990;18(15):4439-46.
1990: O Sakatsume; H Yamane; Hiroshi Takaku; N Yamamoto
Use of new phosphonylating and coupling agents in the synthesis of oligodeoxyribonucleotides via the H-phosphonate approach.
Nucleic acids research 1990;18(11):3327-31.
1990: H Komatsu; T Ichikawa; Hiroshi Takaku; Shigeyuki Yokoyama; Gota Kawai
Recognition by restriction endodeoxyribonuclease EcoRI of octadeoxyribonucleotides containing modified sugar and base moieties.
Nucleic acids symposium series 1990;(22):95-6.
1990: Naoki Sugimoto; N Monden; M Sasaki; S Yamakage; Hiroshi Takaku
Thermodynamics and kinetics for the helix formation of the P3 region in Tetrahymena ribozyme.
Nucleic acids symposium series 1990;(22):45-6.
1990: K Nagai; Shigeyuki Yokoyama; Gota Kawai; R J Shuhadlnik; Hiroshi Takaku
Synthesis and biological activities of 8-substituted 2-5A analogues.
Nucleic acids symposium series 1990;(22):13-4.
1989: O Sakatsume; M Ohtsuki; Hiroshi Takaku; C B Reese
Solid phase synthesis of oligoribonucleotides using the 1-[(2-chloro-4-methyl)phenyl]-4-methoxypiperidin-4-yl (Ctmp) group for the protection of the 2'-hydroxy functions and the H-phosphonate approach.
Nucleic acids research 1989;17(10):3689-97.
1989: S Yamakage; O Sakatsume; Hiroshi Takaku
Synthesis and properties of the box 9R and 9R' sequences of Tetrahymena rRNA.
Nucleic acids symposium series 1989;(21):81-2.
1988: S Yamakage; M Fujii; Y Horinouchi; Hiroshi Takaku
(Butylthio)carbonyl group: a new protecting group for the guanine and uracil residues in oligoribonucleotide synthesis.
Nucleic acids symposium series 1988;(19):9-12.