Preview
Sign-in for full Details 
Sign-in free and Explore the Exciting World of BiomedExperts:
- Over 1.500.000 Profiles
- More than 1.800 Organizations worldwide
- State of the Art Network Visualizations
- Manage your own Profile
- Locate Experts in your Country/Region
- Locate Experts in your 1. and 2. Level Network
- Connect to Experts Worldwide
NetworkView
Yoshinobu Takakura
This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers
together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles
free of charge to researchers worldwide.
Research Profile (preview)
Living Beings
Concepts & Ideas
Chemicals & Drugs
Anatomy
Devices
Procedures
Physiology
Occupations
Sign-in to see full Profile
Network (preview)
92
Nishikawa, Makiya
71
Hashida, Mitsuru
39
Yamashita, Fumiyoshi
17
Watanabe, Yoshihiko
15
Kobayashi, Naoki
14
Takahashi, Yuki
11
Yamaoka, Kiyoshi
10
Mahato, RI
9
Nomura, Takehiko
9
Ogawa, Yoshiyuki
9
Yamasaki, Yasuomi
9
Yasuda, Kei
8
Maruyama, Masato
7
Akamatsu, Kensuke
6
Kawase, Atsushi
Sign-in to see all Coauthors
Publications
Sign-in to see all Publications
Sign in free and see...
Visualized networks:
See your personal network in
sophisticated graphical views
GeoTargeted Searches:
Locate experts around the world
and connect with global collaborators
Research Profiles:
See the visualized research activity
of experts around the globe
Sign-in to see more
Geonetwork of Yoshinobu Takakura (preview)
Cities where this author has publications
Cities where co-authors of this author have publications
Sign-in to see more
All Publications
-
2009: Yata Tomoya; Nishikawa Makiya; Nishizaki Chika; Oku Masahide; Yurimoto Hiroya; Sakai Yasuyoshi; Takakura Yoshinobu
Control of hypoxia-induced tumor cell adhesion by cytophilic human catalase.
Free radical biology & medicine 2009;47(12):1772-8.
-
2009: Rattanakiat Sakulrat; Nishikawa Makiya; Funabashi Hisakage; Luo Dan; Takakura Yoshinobu
The assembly of a short linear natural cytosine-phosphate-guanine DNA into dendritic structures and its effect on immunostimulatory activity.
Biomaterials 2009;30(29):5701-6.
-
2009: Yoshida Hiroyuki; Nishikawa Makiya; Yasuda Sachiyo; Mizuno Yumiko; Toyota Hiroyasu; Kiyota Tsuyoshi; Takahashi Rei; Takakura Yoshinobu
TLR9-dependent systemic interferon-beta production by intravenous injection of plasmid DNA/cationic liposome complex in mice.
The journal of gene medicine 2009;11(8):708-17.
-
2009: Takakura Yoshinobu
Towards therapeutic application of RNA-mediated gene regulation. Preface.
Advanced drug delivery reviews 2009;61(9):667.
-
2009: Takahashi Yuki; Nishikawa Makiya; Takakura Yoshinobu
Nonviral vector-mediated RNA interference: its gene silencing characteristics and important factors to achieve RNAi-based gene therapy.
Advanced drug delivery reviews 2009;61(9):760-6.
-
2009: Maruyama Masato; Ishida Kayo; Watanabe Yoshihiko; Nishikawa Makiya; Takakura Yoshinobu
Effects of methyl-beta-cyclodextrin treatment on secretion profile of interferon-beta and zonula occuludin-1 architecture in Madin-Darby canine kidney cell monolayers.
Biological & pharmaceutical bulletin 2009;32(5):910-5.
-
2009: Isaji Keiko; Kawase Atsushi; Matono Mitsuhiro; Guan Xin; Nishikawa Makiya; Takakura Yoshinobu
Enhanced CTL response by controlled intracellular trafficking of antigen in dendritic cells following DNA vaccination.
Journal of controlled release : official journal of the Controlled Release Society 2009;135(3):227-33.
-
2009: Mitsui Masaru; Nishikawa Makiya; Zang Lei; Ando Mitsuru; Hattori Kayoko; Takahashi Yuki; Watanabe Yoshihiko; Takakura Yoshinobu
Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression.
The journal of gene medicine 2009;11(5):435-43.
-
2009: Nishikawa Makiya; Hashida Mitsuru; Takakura Yoshinobu
Catalase delivery for inhibiting ROS-mediated tissue injury and tumor metastasis.
Advanced drug delivery reviews 2009;61(4):319-26.
-
2009: Takemoto Seiji; Nishikawa Makiya; Otsuki Takayuki; Yamaoka Ayumi; Maeda Kazuki; Ota Atsushi; Takakura Yoshinobu
Enhanced generation of cytotoxic T lymphocytes by increased cytosolic delivery of MHC class I epitope fused to mouse heat shock protein 70 via polyhistidine conjugation.
Journal of controlled release : official journal of the Controlled Release Society 2009;135(1):11-8.
-
2009: Takahashi Yuki; Yamaoka Kiyoshi; Nishikawa Makiya; Takakura Yoshinobu
Quantitative and temporal analysis of gene silencing in tumor cells induced by small interfering RNA or short hairpin RNA expressed from plasmid vectors.
Journal of pharmaceutical sciences 2009;98(1):74-80.
-
2008: Takahashi Yuki; Nishikawa Makiya; Suehara Tetsuya; Takiguchi Naomi; Takakura Yoshinobu
Gene silencing of beta-catenin in melanoma cells retards their growth but promotes the formation of pulmonary metastasis in mice.
International journal of cancer. Journal international du cancer 2008;123(10):2315-20.
-
2008: Nishikawa Makiya; Nakayama Ayumi; Takahashi Yuki; Fukuhara Yasushi; Takakura Yoshinobu
Reactivation of silenced transgene expression in mouse liver by rapid, large-volume injection of isotonic solution.
Human gene therapy 2008;19(10):1009-20.
-
2008: Yoshida Hiroyuki; Nishikawa Makiya; Yasuda Sachiyo; Mizuno Yumiko; Takakura Yoshinobu
Cellular activation by plasmid DNA in various macrophages in primary culture.
Journal of pharmaceutical sciences 2008;97(10):4575-85.
-
2008: Takahashi Yuki; Kaneda Haruka; Takasuka Nana; Hattori Kayoko; Nishikawa Makiya; Watanabe Yoshihiko; Takakura Yoshinobu
Enhancement of antiproliferative activity of interferons by RNA interference-mediated silencing of SOCS gene expression in tumor cells.
Cancer science 2008;99(8):1650-5.
-
2008: Kako Keiko; Nishikawa Makiya; Yoshida Hiroyuki; Takakura Yoshinobu
Effects of inflammatory response on in vivo transgene expression by plasmid DNA in mice.
Journal of pharmaceutical sciences 2008;97(8):3074-83.
-
2008: Ogawa Yoshiyuki; Yoshinaga Takaharu; Nishikawa Makiya; Takakura Yoshinobu
Unique cytokine production profile following stimulation with DNA in macrophages from NZB/W F1 mice.
Biological & pharmaceutical bulletin 2008;31(6):1244-9.
-
2008: Nishikawa Makiya; Matono Mitsuhiro; Rattanakiat Sakulrat; Matsuoka Nao; Takakura Yoshinobu
Enhanced immunostimulatory activity of oligodeoxynucleotides by Y-shape formation.
Immunology 2008;124(2):247-55.
-
2008: Nishikawa Makiya; Takakura Yoshinobu; Hashida Mitsuru
Pharmacokinetic considerations regarding non-viral cancer gene therapy.
Cancer science 2008;99(5):856-62.
-
2008: Takahashi Y; Nishikawa M; Takakura Y
Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1alpha expression in tumor cells and hepatocytes.
Gene therapy 2008;15(8):572-82.
-
2008: Nishikawa Makiya; Takemoto Seiji; Takakura Yoshinobu
Heat shock protein derivatives for delivery of antigens to antigen presenting cells.
International journal of pharmaceutics 2008;354(1-2):23-7.
-
2007: Takahashi Yuki; Nishikawa Makiya; Takakura Yoshinobu
[In vivo siRNA delivery to tumor cells and its application to cancer gene therapy]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2007;127(10):1525-31.
-
2007: Hirata Kazuhiro; Nishikawa Makiya; Kobayashi Naoki; Takahashi Yuki; Takakura Yoshinobu
Design of PCR-amplified DNA fragments for in vivo gene delivery: size-dependency on stability and transgene expression.
Journal of pharmaceutical sciences 2007;96(9):2251-61.
-
2007: Takakura Yoshinobu; Takemoto Seiji; Nishikawa Makiya
Hsp-based tumor vaccines: state-of-the-art and future directions.
Current opinion in molecular therapeutics 2007;9(4):385-91.
-
2007: Kawano Hiroki; Nishikawa Makiya; Mitsui Masaru; Takahashi Yuki; Kako Keiko; Yamaoka Kiyoshi; Watanabe Yoshihiko; Takakura Yoshinobu
Improved anti-cancer effect of interferon gene transfer by sustained expression using CpG-reduced plasmid DNA.
International journal of cancer. Journal international du cancer 2007;121(2):401-6.
-
2007: Fukuhara Yuga; Naoi Tomoyuki; Ogawa Yoshiyuki; Nishikawa Makiya; Takakura Yoshinobu
Plasmid DNA uptake and subsequent cellular activation characteristics in human monocyte-derived cells in primary culture.
Journal of pharmaceutical sciences 2007;96(6):1576-84.
-
2007: Imura Yuichi; Nishida Minoru; Ogawa Yoshiyuki; Takakura Yoshinobu; Matsuzaki Katsumi
Action mechanism of tachyplesin I and effects of PEGylation.
Biochimica et biophysica acta 2007;1768(5):1160-9.
-
2007: Yoshinaga Takaharu; Yasuda Kei; Ogawa Yoshiyuki; Nishikawa Makiya; Takakura Yoshinobu
DNA and its cationic lipid complexes induce CpG motif-dependent activation of murine dendritic cells.
Immunology 2007;120(3):295-302.
-
2007: Nishikawa Makiya; Takemoto Seiji; Takakura Yoshinobu
[Development of heat shock proteins with controlled distribution properties and their application to vaccine delivery]
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2007;127(2):293-300.
-
2007: Yamasaki Yasuomi; Ikenaga Tomoko; Otsuki Takayuki; Nishikawa Makiya; Takakura Yoshinobu
Induction of antigen-specific cytotoxic T lymphocytes by immunization with negatively charged soluble antigen through scavenger receptor-mediated delivery.
Vaccine 2007;25(1):85-91.
-
2006: Takemoto Seiji; Yamaoka Kiyoshi; Nishikawa Makiya; Takakura Yoshinobu
Histogram analysis of pharmacokinetic parameters by bootstrap resampling from one-point sampling data in animal experiments.
Drug metabolism and pharmacokinetics 2006;21(6):458-64.
-
2006: Takahashi Yuki; Nishikawa Makiya; Takakura Yoshinobu
Suppression of tumor growth by intratumoral injection of short hairpin RNA-expressing plasmid DNA targeting beta-catenin or hypoxia-inducible factor 1alpha.
Journal of controlled release : official journal of the Controlled Release Society 2006;116(1):90-5.
-
2006: Kawase Atsushi; Isaji Keiko; Yamaoka Ayumi; Kobayashi Naoki; Nishikawa Makiya; Takakura Yoshinobu
Enhanced antigen-specific antibody production following polyplex-based DNA vaccination via the intradermal route in mice.
Vaccine 2006;24(27-28):5535-45.
-
2006: Takahashi Yuki; Yamaoka Kiyoshi; Nishikawa Makiya; Takakura Yoshinobu
Moment analysis for kinetics of gene silencing by RNA interference.
Biotechnology and bioengineering 2006;93(4):816-9.
-
2005: Nishikawa Makiya; Hyoudou Kenji; Kobayashi Yuki; Umeyama Yukari; Takakura Yoshinobu; Hashida Mitsuru
Inhibition of metastatic tumor growth by targeted delivery of antioxidant enzymes.
Journal of controlled release : official journal of the Controlled Release Society 2005;109(1-3):101-7.
-
2005: Matsui Yumi; Kobayashi Naoki; Nishikawa Makiya; Takakura Yoshinobu
Sequence-specific suppression of mdr1a/1b expression in mice via RNA interference.
Pharmaceutical research 2005;22(12):2091-8.
-
2005: Yamane Ikuko; Nishikawa Makiya; Takakura Yoshinobu
Cellular uptake and activation characteristics of naked plasmid DNA and its cationic liposome complex in human macrophages.
International journal of pharmaceutics 2005;305(1-2):145-53.
-
2005: Ogawa Yoshiyuki; Yoshinaga Takaharu; Yasuda Kei; Nishikawa Makiya; Takakura Yoshinobu
The uptake and degradation of DNA is impaired in macrophages and dendritic cells from NZB/W F(1) mice.
Immunology letters 2005;101(1):32-40.
-
2005: Takahashi Yuki; Nishikawa Makiya; Kobayashi Naoki; Takakura Yoshinobu
Gene silencing in primary and metastatic tumors by small interfering RNA delivery in mice: quantitative analysis using melanoma cells expressing firefly and sea pansy luciferases.
Journal of controlled release : official journal of the Controlled Release Society 2005;105(3):332-43.
-
2005: Maruyama Masato; Kishimoto Michiyuki; Ishida Kayo; Watanabe Yoshihiko; Nishikawa Makiya; Masuda Seiji; Sasaki Ryuzo; Takakura Yoshinobu
Cholesterol is required for the polarized secretion of erythropoietin in Madin-Darby canine kidney cells.
Archives of biochemistry and biophysics 2005;438(2):174-81.
-
2005: Kawase Atsushi; Kobayashi Naoki; Isaji Keiko; Nishikawa Makiya; Takakura Yoshinobu
Manipulation of local disposition and gene expression characteristics of plasmid DNA following intramuscular administration by complexation with cationic macromolecule.
International journal of pharmaceutics 2005;293(1-2):291-301.
-
2005: Kobayashi Naoki; Nishikawa Makiya; Takakura Yoshinobu
The hydrodynamics-based procedure for controlling the pharmacokinetics of gene medicines at whole body, organ and cellular levels.
Advanced drug delivery reviews 2005;57(5):713-31.
-
2005: Nishikawa Makiya; Takakura Yoshinobu; Hashida Mitsuru
Theoretical considerations involving the pharmacokinetics of plasmid DNA.
Advanced drug delivery reviews 2005;57(5):675-88.
-
2005: Takemoto Seiji; Nishikawa Makiya; Takakura Yoshinobu
Pharmacokinetic and tissue distribution mechanism of mouse recombinant heat shock protein 70 in mice.
Pharmaceutical research 2005;22(3):419-26.
-
2005: Kawaguchi Hiroko; Akazawa Yukiko; Watanabe Yoshihiko; Takakura Yoshinobu
Permeability modulation of human intestinal Caco-2 cell monolayers by interferons.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2005;59(1):45-50.
-
2005: Yasuda Kei; Ogawa Yoshiyuki; Yamane Ikuko; Nishikawa Makiya; Takakura Yoshinobu
Macrophage activation by a DNA/cationic liposome complex requires endosomal acidification and TLR9-dependent and -independent pathways.
Journal of leukocyte biology 2005;77(1):71-9.
-
2005: Nishikawa Makiya; Takakura Yoshinobu; Hashida Mitsuru
Pharmacokinetics of plasmid DNA-based non-viral gene medicine.
Advances in genetics 2005;53():47-68.
-
2004: Yamaoka Kiyoshi; Takakura Yoshinobu
Analysis methods and recent advances in nonlinear pharmacokinetics from in vitro through in loci to in vivo.
Drug metabolism and pharmacokinetics 2004;19(6):397-406.
-
2004: Nishio Teruko; Maruyama Masato; Yoshida Toyokazu; Watanabe Yoshihiko; Nishikawa Makiya; Takakura Yoshinobu
Secretion mode and subcellular localization of human interferon-beta exogenously expressed in porcine renal epithelial LLC-PK1 cells.
Biological & pharmaceutical bulletin 2004;27(10):1653-5.
-
2004: Maruyama Masato; Nishio Teruko; Yoshida Toyokazu; Ishida Chisaki; Ishida Kayo; Watanabe Yoshihiko; Nishikawa Makiya; Takakura Yoshinobu
Simultaneous detection of DsRed2-tagged and EGFP-tagged human beta-interferons in the same single cells.
Journal of cellular biochemistry 2004;93(3):497-502.
-
2004: Maruyama Masato; Nishio Teruko; Kato Takako; Yoshida Toyokazu; Ishida Chisaki; Watanabe Yoshihiko; Nishikawa Makiya; Kaneda Yasufumi; Takakura Yoshinobu
Subcellular trafficking of exogenously expressed interferon-beta in Madin-Darby canine kidney cells.
Journal of cellular physiology 2004;201(1):117-25.
-
2004: Nakamura Masaru; Yamaguchi Shinsuke; Watanabe Yoshihiko; Yamashita Fumiyoshi; Takakura Yoshinobu; Hashida Mitsuru
Exogenous expression of interferon-beta in cultured brain microvessel endothelial cells.
Biological & pharmaceutical bulletin 2004;27(9):1441-3.
-
2004: Hisazumi Jin; Kobayashi Naoki; Nishikawa Makiya; Takakura Yoshinobu
Significant role of liver sinusoidal endothelial cells in hepatic uptake and degradation of naked plasmid DNA after intravenous injection.
Pharmaceutical research 2004;21(7):1223-8.
-
2004: Ikenaga Tomoko; Yamasaki Yasuomi; Shakushiro Kohsuke; Nishikawa Makiya; Takakura Yoshinobu
Induction of cytotoxic T lymphocytes following immunization with cationized soluble antigen.
Vaccine 2004;22(20):2609-16.
-
2004: Shakushiro Kohsuke; Yamasaki Yasuomi; Nishikawa Makiya; Takakura Yoshinobu
Efficient scavenger receptor-mediated uptake and cross-presentation of negatively charged soluble antigens by dendritic cells.
Immunology 2004;112(2):211-8.
-
2004: Kobayashi Naoki; Nishikawa Makiya; Hirata Kazuhiro; Takakura Yoshinobu
Hydrodynamics-based procedure involves transient hyperpermeability in the hepatic cellular membrane: implication of a nonspecific process in efficient intracellular gene delivery.
The journal of gene medicine 2004;6(5):584-92.
-
2004: Kobayashi Naoki; Hirata Kazuhiro; Chen Shi; Kawase Atsushi; Nishikawa Makiya; Takakura Yoshinobu
Hepatic delivery of particulates in the submicron range by a hydrodynamics-based procedure: implications for particulate gene delivery systems.
The journal of gene medicine 2004;6(4):455-63.
-
2004: Yasuda Kei; Kawano Hiroki; Yamane Ikuko; Ogawa Yoshiyuki; Yoshinaga Takaharu; Nishikawa Makiya; Takakura Yoshinobu
Restricted cytokine production from mouse peritoneal macrophages in culture in spite of extensive uptake of plasmid DNA.
Immunology 2004;111(3):282-90.
-
2004: Nakamura Masaru; Maruyama Masato; Yamashita Fumiyoshi; Takakura Yoshinobu; Hashida Mitsuru; Watanabe Yoshihiko
Expression and visualization of a human interferon-beta-enhanced green fluorescent protein chimeric molecule in cultured cells.
Biological & pharmaceutical bulletin 2004;27(3):411-4.
-
2004: Kato Takako; Yamaoka Kiyoshi; Takakura Yoshinobu
An evaluation method for nonlinear local disposition in rat liver and kidney.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(2):230-4.
-
2004: Kobayashi Naoki; Matsui Yumi; Kawase Atsushi; Hirata Kazuhiro; Miyagishi Makoto; Taira Kazunari; Nishikawa Makiya; Takakura Yoshinobu
Vector-based in vivo RNA interference: dose- and time-dependent suppression of transgene expression.
The Journal of pharmacology and experimental therapeutics 2004;308(2):688-93.
-
2004: Kawaguchi Hiroko; Matsui Yumi; Watanabe Yoshihiko; Takakura Yoshinobu
Effect of interferon-gamma on the pharmacokinetics of digoxin, a P-glycoprotein substrate, intravenously injected into the mouse.
The Journal of pharmacology and experimental therapeutics 2004;308(1):91-6.
-
2004: Nishikawa Makiya; Tamada Ayumi; Hyoudou Kenji; Umeyama Yukari; Takahashi Yuki; Kobayashi Yuki; Kumai Hitomi; Ishida Emi; Staud Frantisek; Yabe Yoshiyuki; Takakura Yoshinobu; Yamashita Fumiyoshi; Hashida Mitsuru
Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice.
Clinical & experimental metastasis 2004;21(3):213-21.
-
2003: Nishikawa Makiya; Nakano Takayuki; Okabe Takayuki; Hamaguchi Nobuko; Yamasaki Yasuomi; Takakura Yoshinobu; Yamashita Fumiyoshi; Hashida Mitsuru
Residualizing indium-111-radiolabel for plasmid DNA and its application to tissue distribution study.
Bioconjugate chemistry 2003;14(5):955-61.
-
2003: Sakurai Fuminori; Terada Takeshi; Maruyama Masato; Watanabe Yoshihiko; Yamashita Fumiyoshi; Takakura Yoshinobu; Hashida Mitsuru
Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I: poly C in a murine lung metastasis model.
Cancer gene therapy 2003;10(9):661-8.
-
2003: Kawase Atsushi; Nomura Takehiko; Yasuda Kei; Kobayashi Naoki; Hashida Mitsuru; Takakura Yoshinobu
Disposition and gene expression characteristics in solid tumors and skeletal muscle after direct injection of naked plasmid DNA in mice.
Journal of pharmaceutical sciences 2003;92(6):1295-304.
-
2003: Yamasaki Yasuomi; Hisazumi Jin; Yamaoka Kiyoshi; Takakura Yoshinobu
Efficient scavenger receptor-mediated hepatic targeting of proteins by introduction of negative charges on the proteins by aconitylation: the influence of charge density and size of the proteins molecules.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;18(5):305-12.
-
2002: Yabe Yoshiyuki; Kobayashi Naoki; Nishikawa Makiya; Mihara Kiyoshi; Yamashita Fumiyoshi; Takakura Yoshinobu; Hashida Mitsuru
Pharmacokinetics and preventive effects of targeted catalase derivatives on hydrogen peroxide-induced injury in perfused rat liver.
Pharmaceutical research 2002;19(12):1815-21.
-
2002: Kobayashi Naoki; Kuramoto Takeshi; Chen Shi; Watanabe Yoshihiko; Takakura Yoshinobu
Therapeutic effect of intravenous interferon gene delivery with naked plasmid DNA in murine metastasis models.
Molecular therapy : the journal of the American Society of Gene Therapy 2002;6(6):737-44.
-
2002: Yoshinaga Takaharu; Yasuda Kei; Ogawa Yoshiyuki; Takakura Yoshinobu
Efficient uptake and rapid degradation of plasmid DNA by murine dendritic cells via a specific mechanism.
Biochemical and biophysical research communications 2002;299(3):389-94.
-
2002: Akazawa Yukiko; Kawaguchi Hiroko; Funahashi Maki; Watanabe Yoshihiko; Yamaoka Kiyoshi; Hashida Mitsuru; Takakura Yoshinobu
Effect of interferons on P-glycoprotein-mediated rhodamine-123 efflux in cultured rat hepatocytes.
Journal of pharmaceutical sciences 2002;91(10):2110-5.
-
2002: Sakurai F; Terada T; Yasuda K; Yamashita F; Takakura Y; Hashida M
The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes.
Gene therapy 2002;9(16):1120-6.
-
2002: Nakanishi Kiyo; Watanabe Yoshihiko; Maruyama Masato; Yamashita Fumiyoshi; Takakura Yoshinobu; Hashida Mitsuru
Secretion polarity of interferon-beta in epithelial cell lines.
Archives of biochemistry and biophysics 2002;402(2):201-7.
-
2002: Yamasaki Yasuomi; Sumimoto Kazuya; Nishikawa Makiya; Yamashita Fumiyoshi; Yamaoka Kiyoshi; Hashida Mitsuru; Takakura Yoshinobu
Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: importance of molecular size and negative charge density for in vivo recognition by receptors.
The Journal of pharmacology and experimental therapeutics 2002;301(2):467-77.
-
2002: Yasuda Kei; Ogawa Yoshiyuki; Kishimoto Michiyuki; Takagi Toshihide; Hashida Mitsuru; Takakura Yoshinobu
Plasmid DNA activates murine macrophages to induce inflammatory cytokines in a CpG motif-independent manner by complex formation with cationic liposomes.
Biochemical and biophysical research communications 2002;293(1):344-8.
-
2002: Nishikawa Makiya; Hasegawa Susumu; Yamashita Fumiyoshi; Takakura Yoshinobu; Hashida Mitsuru
Electrical charge on protein regulates its absorption from the rat small intestine.
American journal of physiology. Gastrointestinal and liver physiology 2002;282(4):G711-9.
-
2002: Takakura Yoshinobu; Nishikawa Makiya; Yamashita Fumiyoshi; Hashida Mitsuru
Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery.
Journal of drug targeting 2002;10(2):99-104.
-
2001: Akamatsu K; Yamasaki Y; Nishikawa M; Takakura Y; Hashida M
Synthesis and pharmacological activity of a novel water-soluble hepatocyte-specific polymeric prodrug of prostaglandin E(1) using lactosylated poly(L-glutamic hydrazide) as a carrier.
Biochemical pharmacology 2001;62(11):1531-6.
-
2001: Hashida M; Nishikawa M; Yamashita F; Takakura Y
Cell-specific delivery of genes with glycosylated carriers.
Advanced drug delivery reviews 2001;52(3):187-96.
-
2001: Sakurai F; Nishioka T; Yamashita F; Takakura Y; Hashida M
Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V 2001;52(2):165-72.
-
2001: Yabe Y; Kobayashi N; Nishihashi T; Takahashi R; Nishikawa M; Takakura Y; Hashida M
Prevention of neutrophil-mediated hepatic ischemia/reperfusion injury by superoxide dismutase and catalase derivatives.
The Journal of pharmacology and experimental therapeutics 2001;298(3):894-9.
-
2001: Imamura Y; Shimizu K; Yamashita F; Yamaoka K; Takakura Y; Hashida M
Transport characteristics of ebastine and its metabolites across human intestinal epithelial Caco-2 cell monolayers.
Biological & pharmaceutical bulletin 2001;24(8):930-4.
-
2001: Kobayashi N; Kuramoto T; Yamaoka K; Hashida M; Takakura Y
Hepatic uptake and gene expression mechanisms following intravenous administration of plasmid DNA by conventional and hydrodynamics-based procedures.
The Journal of pharmacology and experimental therapeutics 2001;297(3):853-60.
-
2001: Sakurai F; Nishioka T; Saito H; Baba T; Okuda A; Matsumoto O; Taga T; Yamashita F; Takakura Y; Hashida M
Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid.
Gene therapy 2001;8(9):677-86.
-
2001: Opanasopit P; Shirashi K; Nishikawa M; Yamashita F; Takakura Y; Hashida M
In vivo recognition of mannosylated proteins by hepatic mannose receptors and mannan-binding protein.
American journal of physiology. Gastrointestinal and liver physiology 2001;280(5):G879-89.
-
2001: Takakura Y; Nishikawa M; Yamashita F; Hashida M
Development of gene drug delivery systems based on pharmacokinetic studies.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2001;13(1):71-6.
-
2001: Opanasopit P; Nishikawa M; Yamashita F; Takakura Y; Hashida M
Pharmacokinetic analysis of lectin-dependent biodistribution of fucosylated bovine serum albumin: a possible carrier for Kupffer cells.
Journal of drug targeting 2001;9(5):341-51.
-
2000: Sakurai F; Inoue R; Nishino Y; Okuda A; Matsumoto O; Taga T; Yamashita F; Takakura Y; Hashida M
Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression.
Journal of controlled release : official journal of the Controlled Release Society 2000;66(2-3):255-69.
-
2000: Nishikawa M; Yamauchi M; Morimoto K; Ishida E; Takakura Y; Hashida M
Hepatocyte-targeted in vivo gene expression by intravenous injection of plasmid DNA complexed with synthetic multi-functional gene delivery system.
Gene therapy 2000;7(7):548-55.
-
2000: Nakajima S; Koshino Y; Nomura T; Yamashita F; Agrawal S; Takakura Y; Hashida M
Intratumoral pharmacokinetics of oligonucleotides in a tissue-isolated tumor perfusion system.
Antisense & nucleic acid drug development 2000;10(2):105-10.
-
2000: Hashida M; Akamatsu K; Nishikawa M; Yamashita F; Yoshikawa H; Takakura Y
Design of polymeric prodrugs of PGE1 for cell-specific hepatic targeting.
Die Pharmazie 2000;55(3):202-5.
-
2000: Nishikawa M; Takemura S; Yamashita F; Takakura Y; Meijer D K; Hashida M; Swart P J
Pharmacokinetics and in vivo gene transfer of plasmid DNA complexed with mannosylated poly(L-lysine) in mice.
Journal of drug targeting 2000;8(1):29-38.
-
2000: Takagi T; Hashiguchi M; Hiramatsu T; Yamashita F; Takakura Y; Hashida M
Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages.
Journal of drug targeting 2000;7(5):363-71.
-
1999: Hashida M; Akamatsu K; Nishikawa M; Yamashita F; Takakura Y
Design of polymeric prodrugs of prostaglandin E(1) having galactose residue for hepatocyte targeting.
Journal of controlled release : official journal of the Controlled Release Society 1999;62(1-2):253-62.
-
1999: Akamatsu K; Yamasaki Y; Nishikawa M; Takakura Y; Hashida M
Development of a hepatocyte-specific prostaglandin E(1) polymeric prodrug and its potential for preventing carbon tetrachloride-induced fulminant hepatitis in mice.
The Journal of pharmacology and experimental therapeutics 1999;290(3):1242-9.
-
1999: Staud F; Nishikawa M; Morimoto K; Takakura Y; Hashida M
Disposition of radioactivity after injection of liver-targeted proteins labeled with 111In or 125I. Effect of labeling on distribution and excretion of radioactivity in rats.
Journal of pharmaceutical sciences 1999;88(6):577-85.
-
1999: Yabe Y; Nishikawa M; Tamada A; Takakura Y; Hashida M
Targeted delivery and improved therapeutic potential of catalase by chemical modification: combination with superoxide dismutase derivatives.
The Journal of pharmacology and experimental therapeutics 1999;289(2):1176-84.
-
1999: Yabe Y; Koyama Y; Nishikawa M; Takakura Y; Hashida M
Hepatocyte-specific distribution of catalase and its inhibitory effect on hepatic ischemia/reperfusion injury in mice.
Free radical research 1999;30(4):265-74.
-
1999: Takakura Y; Takagi T; Hashiguchi M; Nishikawa M; Yamashita F; Doi T; Imanishi T; Suzuki H; Kodama T; Hashida M
Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class A scavenger receptor knockout mice.
Pharmaceutical research 1999;16(4):503-8.
-
1999: Staud F; Nishikawa M; Takakura Y; Hashida M
Liver uptake and hepato-biliary transfer of galactosylated proteins in rats are determined by the extent of galactosylation.
Biochimica et biophysica acta 1999;1427(2):183-92.
-
1999: Nishikawa M; Staud F; Takemura S; Takakura Y; Hashida M
Pharmacokinetic evaluation of biodistribution data obtained with radiolabeled proteins in mice.
Biological & pharmaceutical bulletin 1999;22(2):214-8.
-
1999: Masuda H; Takakura Y; Hashida M
Pharmacokinetics and disposition characteristics of recombinant decorin after intravenous injection into mice.
Biochimica et biophysica acta 1999;1426(3):420-8.
-
1999: Nomura T; Yasuda K; Yamada T; Okamoto S; Mahato R I; Watanabe Y; Takakura Y; Hashida M
Gene expression and antitumor effects following direct interferon (IFN)-gamma gene transfer with naked plasmid DNA and DC-chol liposome complexes in mice.
Gene therapy 1999;6(1):121-9.
-
1999: Yura H; Yoshimura N; Hamashima T; Akamatsu K; Nishikawa M; Takakura Y; Hashida M
Synthesis and pharmacokinetics of a novel macromolecular prodrug of Tacrolimus (FK506), FK506-dextran conjugate.
Journal of controlled release : official journal of the Controlled Release Society 1999;57(1):87-99.
-
1999: Okamoto S; Nakanishi K; Watanabe Y; Yamashita F; Takakura Y; Hashida M
Stimulation side-dependent asymmetrical secretion of poly I:poly C-induced interferon-beta from polarized epithelial cell lines.
Biochemical and biophysical research communications 1999;254(1):5-9.
-
1999: Ogawara K; Hasegawa S; Nishikawa M; Takakura Y; Hashida M
Pharmacokinetic evaluation of mannosylated bovine serum albumin as a liver cell-specific carrier: quantitative comparison with other hepatotropic ligands.
Journal of drug targeting 1999;6(5):349-60.
-
1998: Yura H; Yoshimura N; Hamashima T; Oka T; Takakura Y; Hashida M
Development of a macromolecular prodrug of FK506: I. Synthesis of FK506-dextran conjugate.
Transplantation proceedings 1998;30(7):3598-9.
-
1998: Kawakami S; Yamashita F; Nishikawa M; Takakura Y; Hashida M
Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes.
Biochemical and biophysical research communications 1998;252(1):78-83.
-
1998: Nishikawa M; Takemura S; Takakura Y; Hashida M
Targeted delivery of plasmid DNA to hepatocytes in vivo: optimization of the pharmacokinetics of plasmid DNA/galactosylated poly(L-lysine) complexes by controlling their physicochemical properties.
The Journal of pharmacology and experimental therapeutics 1998;287(1):408-15.
-
1998: Okamoto S; Watanabe Y; Takakura Y; Hashida M
Cationic liposome-mediated efficient induction of type I interferons by a low dose of poly I:poly C in mouse cell lines.
Journal of biochemistry 1998;124(4):697-701.
-
1998: Yura H; Yoshimura N; Hamashima T; Oka T; Takakura Y; Hashida M
Development of a macromolecular prodrug of FK 506: II: In vitro study for FK 506-dextran conjugate.
Transplantation proceedings 1998;30(4):1031-2.
-
1998: Yoshimura N; Yura H; Hamashima T; Oka T; Takakura Y; Hadhida M
Development of a macromolecular prodrug of FK 506: III: In vivo disposition of FK 506-dextran conjugate.
Transplantation proceedings 1998;30(4):1029-30.
-
1998: Takino T; Koreeda N; Nomura T; Sakaeda T; Yamashita F; Takakura Y; Hashida M
Control of plasma cholesterol-lowering action of probucol with various lipid carrier systems.
Biological & pharmaceutical bulletin 1998;21(5):492-7.
-
1998: Hashida M; Takemura S; Nishikawa M; Takakura Y
Targeted delivery of plasmid DNA complexed with galactosylated poly(L-lysine).
Journal of controlled release : official journal of the Controlled Release Society 1998;53(1-3):301-10.
-
1998: Takagi T; Hashiguchi M; Mahato R I; Tokuda H; Takakura Y; Hashida M
Involvement of specific mechanism in plasmid DNA uptake by mouse peritoneal macrophages.
Biochemical and biophysical research communications 1998;245(3):729-33.
-
1998: Nakamura M; Davila-Zavala P; Tokuda H; Takakura Y; Hashida M
Uptake and gene expression of naked plasmid DNA in cultured brain microvessel endothelial cells.
Biochemical and biophysical research communications 1998;245(1):235-9.
-
1998: Nomura T; Saikawa A; Morita S; Sakaeda Kakutani T; Yamashita F; Honda K; Takakura Y; Hashida M
Pharmacokinetic characteristics and therapeutic effects of mitomycin C-dextran conjugates after intratumoural injection.
Journal of controlled release : official journal of the Controlled Release Society 1998;52(3):239-52.
-
1998: Takakura Y
[Drug delivery systems in gene therapy]
Nippon rinsho. Japanese journal of clinical medicine 1998;56(3):691-5.
-
1998: Takakura Y; Oka Y; Hashida M
Cellular uptake properties of oligonucleotides in LLC-PK1 renal epithelial cells.
Antisense & nucleic acid drug development 1998;8(1):67-73.
-
1998: Ogawara K; Nishikawa M; Takakura Y; Hashida M
Pharmacokinetic analysis of hepatic uptake of galactosylated bovine serum albumin in a perfused rat liver.
Journal of controlled release : official journal of the Controlled Release Society 1998;50(1-3):309-17.
-
1998: Nomura T; Koreeda N; Yamashita F; Takakura Y; Hashida M
Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors.
Pharmaceutical research 1998;15(1):128-32.
-
1998: Akamatsu K; Imai M; Yamasaki Y; Nishikawa M; Takakura Y; Hashida M
Disposition characteristics of glycosylated poly(amino acids) as liver cell-specific drug carrier.
Journal of drug targeting 1998;6(3):229-39.
-
1998: Kanamaru T; Takagi T; Takakura Y; Hashida M
Biological effects and cellular uptake of c-myc antisense oligonucleotides and their cationic liposome complexes.
Journal of drug targeting 1998;5(4):235-46.
-
1997: Nomura T; Nakajima S; Kawabata K; Yamashita F; Takakura Y; Hashida M
Intratumoral pharmacokinetics and in vivo gene expression of naked plasmid DNA and its cationic liposome complexes after direct gene transfer.
Cancer research 1997;57(13):2681-6.
-
1997: Bando H; Mohri S; Yamashita F; Takakura Y; Hashida M
Effects of skin metabolism on percutaneous penetration of lipophilic drugs.
Journal of pharmaceutical sciences 1997;86(6):759-61.
-
1997: Kawabata K; Kondo M; Watanabe Y; Takakura Y; Hashida M
Non-polarized secretion of mouse interferon-beta from gene-transferred human intestinal Caco-2 cells.
Pharmaceutical research 1997;14(4):483-5.
-
1997: Takagi T; Kitano M; Masuda S; Tokuda H; Takakura Y; Hashida M
Augmented inhibitory effect of superoxide dismutase on superoxide anion release from macrophages by direct cationization.
Biochimica et biophysica acta 1997;1335(1-2):91-8.
-
1997: Mahato R I; Takemura S; Akamatsu K; Nishikawa M; Takakura Y; Hashida M
Physicochemical and disposition characteristics of antisense oligonucleotides complexed with glycosylated poly(L-lysine).
Biochemical pharmacology 1997;53(6):887-95.
-
1997: Nomura T; Takakura Y; Hashida M
[Cancer gene therapy by direct intratumoral injection: gene expression and intratumoral pharmacokinetics of plasmid DNA]
Gan to kagaku ryoho. Cancer & chemotherapy 1997;24(4):483-8.
-
1997: Bando H; Sahashi M; Yamashita F; Takakura Y; Hashida M
In vivo evaluation of acyclovir prodrug penetration and metabolism through rat skin using a diffusion/bioconversion model.
Pharmaceutical research 1997;14(1):56-62.
-
1997: Mahato R I; Takakura Y; Hashida M
Development of targeted delivery systems for nucleic acid drugs.
Journal of drug targeting 1997;4(6):337-57.
-
1997: Mahato R I; Takakura Y; Hashida M
Nonviral vectors for in vivo gene delivery: physicochemical and pharmacokinetic considerations.
Critical reviews in therapeutic drug carrier systems 1997;14(2):133-72.
-
1996: Saikawa A; Nomura T; Yamashita F; Takakura Y; Sezaki H; Hashida M
Pharmacokinetic analysis of drug disposition after intratumoral injection in a tissue-isolated tumor perfusion system.
Pharmaceutical research 1996;13(10):1438-44.
-
1996: Sawai K; Mahato R I; Oka Y; Takakura Y; Hashida M
Disposition of oligonucleotides in isolated perfused rat kidney: involvement of scavenger receptors in their renal uptake.
The Journal of pharmacology and experimental therapeutics 1996;279(1):284-90.
-
1996: Hirabayashi H; Nishikawa M; Takakura Y; Hashida M
Development and pharmacokinetics of galactosylated poly-L-glutamic acid as a biodegradable carrier for liver-specific drug delivery.
Pharmaceutical research 1996;13(6):880-4.
-
1996: Takakura Y; Hashida M
Macromolecular carrier systems for targeted drug delivery: pharmacokinetic considerations on biodistribution.
Pharmaceutical research 1996;13(6):820-31.
-
1996: Yoshida M; Mahato R I; Kawabata K; Takakura Y; Hashida M
Disposition characteristics of plasmid DNA in the single-pass rat liver perfusion system.
Pharmaceutical research 1996;13(4):599-603.
-
1996: Bando H; Takagi T; Yamashita F; Takakura Y; Hashida M
Theoretical design of prodrug-enhancer combination based on a skin diffusion model: prediction of permeation of acyclovir prodrugs treated with 1-geranylazacycloheptan-2-one.
Pharmaceutical research 1996;13(3):427-32.
-
1996: Takakura Y; Mahato R I; Yoshida M; Kanamaru T; Hashida M
Uptake characteristics of oligonucleotides in the isolated rat liver perfusion system.
Antisense & nucleic acid drug development 1996;6(3):177-83.
-
1996: Jani P U; Nomura T; Yamashita F; Takakura Y; Florence A T; Hashida M
Biliary excretion of polystyrene microspheres with covalently linked FITC fluorescence after oral and parenteral administration to male Wistar rats.
Journal of drug targeting 1996;4(2):87-93.
-
1995: Yamashita F; Bando H; Takakura Y; Hashida M
A deconvolution method for estimating the first-pass metabolism of orally administered drugs.
Biological & pharmaceutical bulletin 1995;18(12):1787-9.
-
1995: Takakura Y; Morita T; Fujikawa M; Hayashi M; Sezaki H; Hashida M; Borchardt R T
Characterization of LLC-PK1 kidney epithelial cells as an in vitro model for studying renal tubular reabsorption of protein drugs.
Pharmaceutical research 1995;12(12):1968-72.
-
1995: Mahato R I; Kawabata K; Nomura T; Takakura Y; Hashida M
Physicochemical and pharmacokinetic characteristics of plasmid DNA/cationic liposome complexes.
Journal of pharmaceutical sciences 1995;84(11):1267-71.
-
1995: Kawabata K; Takakura Y; Hashida M
The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake.
Pharmaceutical research 1995;12(6):825-30.
-
1995: Nishikawa M; Miyazaki C; Yamashita F; Takakura Y; Hashida M
Galactosylated proteins are recognized by the liver according to the surface density of galactose moieties.
The American journal of physiology 1995;268(5 Pt 1):G849-56.
-
1995: Nishikawa M; Hirabayashi H; Takakura Y; Hashida M
Design for cell-specific targeting of proteins utilizing sugar-recognition mechanism: effect of molecular weight of proteins on targeting efficiency.
Pharmaceutical research 1995;12(2):209-14.
-
1995: Sawai K; Miyao T; Takakura Y; Hashida M
Renal disposition characteristics of oligonucleotides modified at terminal linkages in the perfused rat kidney.
Antisense research and development 1995;5(4):279-87.
-
1995: Miyao T; Takakura Y; Akiyama T; Yoneda F; Sezaki H; Hashida M
Stability and pharmacokinetic characteristics of oligonucleotides modified at terminal linkages in mice.
Antisense research and development 1995;5(2):115-21.
-
1995: Mahato R I; Kawabata K; Takakura Y; Hashida M
In vivo disposition characteristics of plasmid DNA complexed with cationic liposomes.
Journal of drug targeting 1995;3(2):149-57.
-
1994: Bando H; Yamashita F; Takakura Y; Hashida M
Skin penetration enhancement of acyclovir by prodrug-enhancer combination.
Biological & pharmaceutical bulletin 1994;17(8):1141-3.
-
1994: Morita T; Yamamoto A; Takakura Y; Hashida M; Sezaki H
Improvement of the pulmonary absorption of (Asu1,7)-eel calcitonin by various protease inhibitors in rats.
Pharmaceutical research 1994;11(6):909-13.
-
1994: Takakura Y; Masuda S; Tokuda H; Nishikawa M; Hashida M
Targeted delivery of superoxide dismutase to macrophages via mannose receptor-mediated mechanism.
Biochemical pharmacology 1994;47(5):853-8.
-
1994: Koyama Y; Bando H; Yamashita F; Takakura Y; Sezaki H; Hashida M
Comparative analysis of percutaneous absorption enhancement by d-limonene and oleic acid based on a skin diffusion model.
Pharmaceutical research 1994;11(3):377-83.
-
1994: Yamashita F; Bando H; Koyama Y; Kitagawa S; Takakura Y; Hashida M
In vivo and in vitro analysis of skin penetration enhancement based on a two-layer diffusion model with polar and nonpolar routes in the stratum corneum.
Pharmaceutical research 1994;11(2):185-91.
-
1994: Mihara K; Sawai K; Takakura Y; Hashida M
Manipulation of renal disposition of human recombinant superoxide dismutase by chemical modification.
Biological & pharmaceutical bulletin 1994;17(2):296-301.
-
1994: Takakura Y; Miyao T; Kawabata K; Hashida M
[Control of in vivo characteristics of gene and antisense DNA disposition]
Gan to kagaku ryoho. Cancer & chemotherapy 1994;21(3):320-4.
-
1994: Takino T; Konishi K; Takakura Y; Hashida M
Long circulating emulsion carrier systems for highly lipophilic drugs.
Biological & pharmaceutical bulletin 1994;17(1):121-5.
-
1994: Fujita T; Nishikawa M; Ohtsubo Y; Ohno J; Takakura Y; Sezaki H; Hashida M
Control of in vivo fate of albumin derivatives utilizing combined chemical modification.
Journal of drug targeting 1994;2(2):157-65.
-
1994: Mihara K; Oka Y; Sawai K; Takakura Y; Hashida M
Improvement of therapeutic effect of human recombinant superoxide dismutase on ischemic acute renal failure in the rat via cationization and conjugation with polyethylene glycol.
Journal of drug targeting 1994;2(4):317-21.
-
1993: Tokuda H; Masuda S; Takakura Y; Sezaki H; Hashida M
Specific uptake of succinylated proteins via a scavenger receptor-mediated mechanism in cultured brain microvessel endothelial cells.
Biochemical and biophysical research communications 1993;196(1):18-24.
-
1993: Nishikawa M; Kamijo A; Fujita T; Takakura Y; Sezaki H; Hashida M
Synthesis and pharmacokinetics of a new liver-specific carrier, glycosylated carboxymethyl-dextran, and its application to drug targeting.
Pharmaceutical research 1993;10(9):1253-61.
-
1993: Mihara K; Hojo T; Fujikawa M; Takakura Y; Sezaki H; Hashida M
Disposition characteristics of protein drugs in the perfused rat kidney.
Pharmaceutical research 1993;10(6):823-7.
-
1993: Mihara K; Mori M; Hojo T; Takakura Y; Sezaki H; Hashida M
Disposition characteristics of model macromolecules in the perfused rat kidney.
Biological & pharmaceutical bulletin 1993;16(2):158-62.
-
1993: Takino T; Nakajima C; Takakura Y; Sezaki H; Hashida M
Controlled biodistribution of highly lipophilic drugs with various parenteral formulations.
Journal of drug targeting 1993;1(2):117-24.
-
1992: Fujita T; Nishikawa M; Tamaki C; Takakura Y; Hashida M; Sezaki H
Targeted delivery of human recombinant superoxide dismutase by chemical modification with mono- and polysaccharide derivatives.
The Journal of pharmacology and experimental therapeutics 1992;263(3):971-8.
-
1992: Fujita T; Furitsu H; Nishikawa M; Takakura Y; Sezaki H; Hashida M
Therapeutic effects of superoxide dismutase derivatives modified with mono- or polysaccharides on hepatic injury induced by ischemia/reperfusion.
Biochemical and biophysical research communications 1992;189(1):191-6.
-
1992: Imoto H; Sakamura Y; Ohkouchi K; Atsumi R; Takakura Y; Sezaki H; Hashida M
Disposition characteristics of macromolecules in the perfused tissue-isolated tumor preparation.
Cancer research 1992;52(16):4396-401.
-
1991: Fujita T; Yasuda Y; Takakura Y; Hashida M; Sezaki H
Tissue distribution of 111In-labeled uricase conjugated with charged dextrans and polyethylene glycol.
Journal of pharmacobio-dynamics 1991;14(11):623-9.
-
1991: Nishida K; Eguchi Y; Takino T; Takakura Y; Hashida M; Sezaki H
Hepatic disposition characteristics of 111In-labeled lactosaminated bovine serum albumin in rats.
Pharmaceutical research 1991;8(10):1253-7.
-
1991: Nishida K; Mihara K; Takino T; Nakane S; Takakura Y; Hashida M; Sezaki H
Hepatic disposition characteristics of electrically charged macromolecules in rat in vivo and in the perfused liver.
Pharmaceutical research 1991;8(4):437-44.
-
1990: Hashida M; Atsumi R; Nishida K; Nakane S; Takakura Y; Sezaki H
Biliary excretion of mitomycin C dextran conjugates in relation to physicochemical characteristics of carrier dextran.
Journal of pharmacobio-dynamics 1990;13(7):441-7.
-
1990: Yasuda Y; Fujita T; Takakura Y; Hashida M; Sezaki H
Biochemical and biopharmaceutical properties of macromolecular conjugates of uricase with dextran and polyethylene glycol.
Chemical & pharmaceutical bulletin 1990;38(7):2053-6.
-
1990: Takakura Y; Fujita T; Hashida M; Sezaki H
Disposition characteristics of macromolecules in tumor-bearing mice.
Pharmaceutical research 1990;7(4):339-46.
-
1990: Ohkouchi K; Imoto H; Takakura Y; Hashida M; Sezaki H
Disposition of anticancer drugs after bolus arterial administration in a tissue-isolated tumor perfusion system.
Cancer research 1990;50(5):1640-4.
-
1989: Takakura Y; Fujita T; Hashida M; Maeda H; Sezaki H
Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. II: Biopharmaceutical and pharmacological properties.
Journal of pharmaceutical sciences 1989;78(3):219-22.
-
1989: Takakura Y; Kaneko Y; Fujita T; Hashida M; Maeda H; Sezaki H
Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. I: Synthesis and characterization.
Journal of pharmaceutical sciences 1989;78(2):117-21.
-
1989: Sato K; Itakura K; Nishida K; Takakura Y; Hashida M; Sezaki H
Disposition of a polymeric prodrug of mitomycin C, mitomycin C-dextran conjugate, in the perfused rat liver.
Journal of pharmaceutical sciences 1989;78(1):11-6.
-
1987: Atsumi R; Endo K; Kakutani T; Takakura Y; Hashida M; Sezaki H
Disposition characteristics of mitomycin C-dextran conjugate in normal and tumor-bearing muscles of rabbits.
Cancer research 1987;47(21):5546-51.
-
1987: Takakura Y; Takagi A; Hashida M; Sezaki H
Disposition and tumor localization of mitomycin C-dextran conjugates in mice.
Pharmaceutical research 1987;4(4):293-300.
Sign-in to see more
