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Mikihisa Takano

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Junya Nagai; Ayaka Yamamoto; Ryoko Yumoto; Mikihisa Takano
Albumin overload induces expression of hypoxia-inducible factor 1α and its target genes in HK-2 human renal proximal tubular cell line.
Ryoko Yumoto; Saki Kakizoe; Junya Nagai; Denpong Patanasethanont; Bungorn Sripanidkulchai; Mikihisa Takano
Flow Cytometry Analysis of Cancer Cell Death Induced by the Extract of Thai Plant Ellipeiopsis cherrevensis.
Junya Nagai; Takuji Komeda; Ryoko Yumoto; Mikihisa Takano
Effect of protamine on the accumulation of gentamicin in opossum kidney epithelial cells.

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All Publications

2013: Junya Nagai; Ayaka Yamamoto; Ryoko Yumoto; Mikihisa Takano
Albumin overload induces expression of hypoxia-inducible factor 1α and its target genes in HK-2 human renal proximal tubular cell line.
Biochemical and biophysical research communications 2013;434(3):670-5.
2013: Ryoko Yumoto; Saki Kakizoe; Junya Nagai; Denpong Patanasethanont; Bungorn Sripanidkulchai; Mikihisa Takano
Flow Cytometry Analysis of Cancer Cell Death Induced by the Extract of Thai Plant Ellipeiopsis cherrevensis.
Drug metabolism and pharmacokinetics 2013;28(2):159-63.
2013: Junya Nagai; Takuji Komeda; Ryoko Yumoto; Mikihisa Takano
Effect of protamine on the accumulation of gentamicin in opossum kidney epithelial cells.
The Journal of pharmacy and pharmacology 2013;65(3):441-6.
2012: Mikihisa Takano; Taishi Horiuchi; Junya Nagai; Ryoko Yumoto
Effect of cigarette smoke extract on insulin transport in alveolar epithelial cell line A549.
Lung 2012;190(6):651-9.
2012: Yasufumi Fukano; Hajime Mizuno; Mikihisa Takano; Naohiro Tsuyama; Sachiko Date; Tsutomu Masujima
Drug metabolite heterogeneity in cultured single cells profiled by pico-trapping direct mass spectrometry.
Nanomedicine (London, England) 2012;7(9):1365-74.
2012: Keisuke Oda; Hirokazu Katayama; Junya Nagai; Ryoko Yumoto; Mikihisa Takano
Enhancement effect of poly(amino acid)s on insulin uptake in alveolar epithelial cells.
Drug metabolism and pharmacokinetics 2012;27(6):570-8.
2012: Ryoko Yumoto; Junya Nagai; Keisuke Oda; Sayuri Suzuka; Mikihisa Takano
Endocytic uptake of FITC-albumin by human alveolar epithelial cell line A549.
Drug metabolism and pharmacokinetics 2012;27(3):336-43.
2011: Keisuke Oda; Hirokazu Katayama; Junya Nagai; Ryoko Yumoto; Mikihisa Takano
Mechanism underlying insulin uptake in alveolar epithelial cell line RLE-6TN.
European journal of pharmacology 2011;672(1-3):62-9.
2011: Sayo Horibe; Junya Nagai; Ryoko Yumoto; Riichi Tawa; Mikihisa Takano
Accumulation and photodynamic activity of chlorin e6 in cisplatin-resistant human lung cancer cells.
Journal of pharmaceutical sciences 2011;100(7):3010-7.
2011: Junya Nagai; Koya Sato; Ryoko Yumoto; Mikihisa Takano
Megalin/cubilin-mediated uptake of FITC-labeled IgG by OK kidney epithelial cells.
Drug metabolism and pharmacokinetics 2011;26(5):474-85.
2010: Junya Nagai; Mikihisa Takano
Molecular-targeted approaches to reduce renal accumulation of nephrotoxic drugs.
Expert opinion on drug metabolism & toxicology 2010;6(9):1125-38.
2010: Mikihisa Takano; Eri Kimura; Satoshi Suzuki; Junya Nagai; Ryoko Yumoto
Human erythrocyte nucleoside transporter ENT1 functions at ice-cold temperatures.
Drug metabolism and pharmacokinetics 2010;25(4):351-60.
2010: Masashi Kawami; Ryoko Yumoto; Junya Nagai; Varaporn Buraphacheep Junyaprasert; Noppamas Soonthornchareonnon; Denpong Patanasethanont; Bungorn Sripanidkulchai; Mikihisa Takano
Effect of Thai plant extracts on P-glycoprotein function and viability in paclitaxel-resistant HepG2 cells.
Drug metabolism and pharmacokinetics 2010;25(2):155-62.
2010: Yuka Ishikawa; Junya Nagai; Yumi Okada; Koya Sato; Ryoko Yumoto; Mikihisa Takano
Function and expression of ATP-binding cassette transporters in cultured human Y79 retinoblastoma cells.
Biological & pharmaceutical bulletin 2010;33(3):504-11.
2009: Koya Sato; Junya Nagai; Naoko Mitsui; Mikihisa Takano
Effects of endocytosis inhibitors on internalization of human IgG by Caco-2 human intestinal epithelial cells.
Life sciences 2009;85(23-26):800-7.
2009: Mika Ikehata; Ryoko Yumoto; Yuki Kato; Junya Nagai; Mikihisa Takano
Mechanism of insulin uptake in rat alveolar type II and type I-like epithelial cells.
Biological & pharmaceutical bulletin 2009;32(10):1765-9.
2009: Kenji Fujii; Junya Nagai; Takeshi Sawada; Ryoko Yumoto; Mikihisa Takano
Effect of PEGylation of N-WASP181-200 on the inhibitory potency for renal aminoglycoside accumulation.
Bioconjugate chemistry 2009;20(8):1553-8.
2009: Ryoko Yumoto; Shota Hamada; Kaori Okada; Yuki Kato; Mika Ikehata; Junya Nagai; Mikihisa Takano
Effect of ursodeoxycholic acid treatment on the expression and function of multidrug resistance-associated protein 2 in rat intestine.
Journal of pharmaceutical sciences 2009;98(8):2822-31.
2009: Mikihisa Takano; Yoshifumi Otani; Minori Tanda; Masashi Kawami; Junya Nagai; Ryoko Yumoto
Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in the human hepatoma cell line, HepG2.
Drug metabolism and pharmacokinetics 2009;24(5):418-27.
2008: Takanori Taogoshi; Junya Nagai; Ryoko Yumoto; Mikihisa Takano
Transport of prostaglandin E1 across rat erythrocyte membrane.
Biological & pharmaceutical bulletin 2008;31(6):1288-91.
2008: Mika Ikehata; Ryoko Yumoto; Kosuke Nakamura; Junya Nagai; Mikihisa Takano
Comparison of albumin uptake in rat alveolar type II and type I-like epithelial cells in primary culture.
Pharmaceutical research 2008;25(4):913-22.
2008: Sachiko Murakami; Junya Nagai; Kenji Fujii; Ryoko Yumoto; Mikihisa Takano
Influences of dosage regimen and co-administration of low-molecular weight proteins and basic peptides on renal accumulation of arbekacin in mice.
The Journal of antimicrobial chemotherapy 2008;61(3):658-64.
2008: Maki Tagawa; Ryoko Yumoto; Keisuke Oda; Junya Nagai; Mikihisa Takano
Low-affinity transport of FITC-albumin in alveolar type II epithelial cell line RLE-6TN.
Drug metabolism and pharmacokinetics 2008;23(5):318-27.
2007: Tomoharu Yokooji; Teruo Murakami; Ryoko Yumoto; Junya Nagai; Mikihisa Takano
Role of intestinal efflux transporters in the intestinal absorption of methotrexate in rats.
The Journal of pharmacy and pharmacology 2007;59(9):1263-70.
2007: Denpong Patanasethanont; Junya Nagai; Chie Matsuura; Kyoko Fukui; Khaetthareeya Sutthanut; Bungorn Sripanidkulchai; Ryoko Yumoto; Mikihisa Takano
Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components.
European journal of pharmacology 2007;566(1-3):67-74.
2007: Tomoharu Yokooji; Teruo Murakami; Ryoko Yumoto; Junya Nagai; Mikihisa Takano
Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells.
The Journal of pharmacy and pharmacology 2007;59(4):513-20.
2007: Denpong Patanasethanont; Junya Nagai; Ryoko Yumoto; Teruo Murakami; Khaetthareeya Sutthanut; Bungorn Sripanidkulchai; Chavi Yenjai; Mikihisa Takano
Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function.
Journal of pharmaceutical sciences 2007;96(1):223-33.
2006: Tomoharu Yokooji; Teruo Murakami; Ryoko Yumoto; Junya Nagai; Mikihisa Takano
Function of multidrug resistance-associated protein 2 in acute hepatic failure rats.
European journal of pharmacology 2006;546(1-3):152-60.
2006: Kumiko Ogawa; Ryoko Yumoto; Natsuki Hamada; Junya Nagai; Mikihisa Takano
Interaction of valproic acid and carbapenem antibiotics with multidrug resistance-associated proteins in rat erythrocyte membranes.
Epilepsy research 2006;71(1):76-87.
2006: Junya Nagai; Takanori Taogoshi; Akiko Tokunaga; Hiroaki Nishikawa; Teruo Murakami; Mikihisa Takano
Characterization of prostaglandin E1 transport in rat renal brush-border membrane.
Drug metabolism and pharmacokinetics 2006;21(3):186-93.
2006: Junya Nagai; Masaki Saito; Yoshinori Adachi; Ryoko Yumoto; Mikihisa Takano
Inhibition of gentamicin binding to rat renal brush-border membrane by megalin ligands and basic peptides.
Journal of controlled release : official journal of the Controlled Release Society 2006;112(1):43-50.
2006: Ryoko Yumoto; Hiromi Nishikawa; Miho Okamoto; Hirokazu Katayama; Junya Nagai; Mikihisa Takano
Clathrin-mediated endocytosis of FITC-albumin in alveolar type II epithelial cell line RLE-6TN.
American journal of physiology. Lung cellular and molecular physiology 2006;290(5):L946-55.
2006: Mikihisa Takano; Ryoko Yumoto; Teruo Murakami
Expression and function of efflux drug transporters in the intestine.
Pharmacology & therapeutics 2006;109(1-2):137-61.
2005: Junya Nagai; Reishi Nasu; Teruo Murakami; Mikihisa Takano
Characterization of prostaglandin E1 transport by rat renal cortical slices.
European journal of pharmacology 2005;525(1-3):128-34.
2005: Kei Omoda; Teruo Murakami; Ryoko Yumoto; Junya Nagai; Yorinobu Maeda; Yoshie Kiribayashi; Mikihisa Takano
Increased erythrocyte distribution of valproic acid in pharmacokinetic interaction with carbapenem antibiotics in rat and human.
Journal of pharmaceutical sciences 2005;94(8):1685-93.
2005: Sachiyo Funakoshi; Teruo Murakami; Ryoko Yumoto; Yoshie Kiribayashi; Mikihisa Takano
Role of organic anion transporting polypeptide 2 in pharmacokinetics of digoxin and beta-methyldigoxin in rats.
Journal of pharmaceutical sciences 2005;94(6):1196-203.
2005: Tomoharu Yokooji; Teruo Murakami; Kumiko Ogawa; Ryoko Yumoto; Junya Nagai; Mikihisa Takano
Modulation of intestinal transport of 2,4-dinitrophenyl-S-glutathione, a multidrug resistance-associated protein 2 substrate, by bilirubin treatment in rats.
The Journal of pharmacy and pharmacology 2005;57(5):579-85.
2005: Hiroaki Ikeda; Teruo Murakami; Mikihisa Takano; Tsuguru Usui; Kenji Kihira
Pharmacokinetic interaction on valproic acid and recurrence of epileptic seizures during chemotherapy in an epileptic patient.
British journal of clinical pharmacology 2005;59(5):593-7.
2005: T Taogoshi; A Nomura; Teruo Murakami; Junya Nagai; Mikihisa Takano
Transport of prostaglandin E1 across the blood-brain barrier in rats.
The Journal of pharmacy and pharmacology 2005;57(1):61-6.
2004: Yuko Ishibashi; Teruo Murakami; Ryoko Yumoto; Masahiko Sakai; Hiromichi Shintani; Hideyuki Itaha; Masayuki Kanbe; Shin Masuda; Koji Yajin; Kenji Kihira; Mikihisa Takano
[Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2004;124(11):833-40.
2004: Mikihisa Takano; Yuka Koyama; Hiromi Nishikawa; Teruo Murakami; Ryoko Yumoto
Segment-selective absorption of lysozyme in the intestine.
European journal of pharmacology 2004;502(1-2):149-55.
2004: Junya Nagai; Mikihisa Takano
Molecular aspects of renal handling of aminoglycosides and strategies for preventing the nephrotoxicity.
Drug metabolism and pharmacokinetics 2004;19(3):159-70.
2004: Teruo Murakami; Akiko Sato; Michiyasu Inatani; Hanao Sakurai; Ryoko Yumoto; Junya Nagai; Mikihisa Takano
Effect of neonatal exposure of 17beta-estradiol and tamoxifen on hepatic CYP3A activity at developmental periods in rats.
Drug metabolism and pharmacokinetics 2004;19(2):96-102.
2004: Ayahisa Watanabe; Junya Nagai; Yoshinori Adachi; Takayuki Katsube; Yasumi Kitahara; Teruo Murakami; Mikihisa Takano
Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists.
Journal of controlled release : official journal of the Controlled Release Society 2004;95(3):423-33.
2004: Yorinobu Maeda; Yoshie Kiribayashi; Takashi Moriya; Akira Maruhashi; Kei Omoda; Sachiyo Funakoshi; Teruo Murakami; Mikihisa Takano
Dosage adjustment of ribavirin based on renal function in Japanese patients with chronic hepatitis C.
Therapeutic drug monitoring 2004;26(1):9-15.
2003: Sachiyo Funakoshi; Teruo Murakami; Ryoko Yumoto; Yoshie Kiribayashi; Mikihisa Takano
Role of P-glycoprotein in pharmacokinetics and drug interactions of digoxin and beta-methyldigoxin in rats.
Journal of pharmaceutical sciences 2003;92(7):1455-63.
2003: Ryoko Yumoto; Teruo Murakami; Mikihisa Takano
Differential effect of acute hepatic failure on in vivo and in vitro P-glycoprotein functions in the intestine.
Pharmaceutical research 2003;20(5):765-71.
2002: Junya Nagai; Takayuki Katsube; Teruo Murakami; Mikihisa Takano
Effect of gentamicin on pharmacokinetics of lysozyme in rats: interaction between megalin substrates in the kidney.
The Journal of pharmacy and pharmacology 2002;54(11):1491-6.
2002: Mikihisa Takano; Naoki Nakanishi; Yasumi Kitahara; Yuki Sasaki; Teruo Murakami; Junya Nagai
Cisplatin-induced inhibition of receptor-mediated endocytosis of protein in the kidney.
Kidney international 2002;62(5):1707-17.
2002: Teruo Murakami; Takeshi Fukuda; Ryoko Yumoto; Junya Nagai; Taiju Kuramoto; Mikihisa Takano
Interaction of endogenous compounds in human and rat urine with P-glycoprotein.
Drug metabolism and pharmacokinetics 2002;17(3):245-52.
2001: Junya Nagai; H Tanaka; N Nakanishi; Teruo Murakami; Mikihisa Takano
Role of megalin in renal handling of aminoglycosides.
American journal of physiology. Renal physiology 2001;281(2):F337-44.
2001: Z H Huang; Teruo Murakami; A Okochi; R Yumoyo; Junya Nagai; Mikihisa Takano
Expression and function of P-glycoprotein in rats with carbon tetrachloride-induced acute hepatic failure.
The Journal of pharmacy and pharmacology 2001;53(6):873-81.
2001: Y Sasaki; Junya Nagai; Yasumi Kitahara; N Takai; Teruo Murakami; Mikihisa Takano
Expression of chloride channel, ClC-5, and its role in receptor-mediated endocytosis of albumin in OK cells.
Biochemical and biophysical research communications 2001;282(1):212-8.
2001: Ryoko Yumoto; Teruo Murakami; M Sanemasa; R Nasu; Junya Nagai; Mikihisa Takano
Pharmacokinetic interaction of cytochrome P450 3A-related compounds with rhodamine 123, a P-glycoprotein substrate, in rats pretreated with dexamethasone.
Drug metabolism and disposition: the biological fate of chemicals 2001;29(2):145-51.
2000: Z H Huang; Teruo Murakami; A Okochi; Ryoko Yumoto; Junya Nagai; Mikihisa Takano
Expression and function of P-glycoprotein in rats with glycerol-induced acute renal failure.
European journal of pharmacology 2000;406(3):453-60.
2000: Tetsu Kajikawa; Hiromu K Mishima; Teruo Murakami; Mikihisa Takano
Role of P-glycoprotein in ocular clearance of rhodamine 123 in rabbits.
Pharmaceutical research 2000;17(4):479-81.
2000: Y Shiraishi; Junya Nagai; Teruo Murakami; Mikihisa Takano
Effect of cisplatin on H+ transport by H+ -ATPase and Na+/H+ exchanger in rat renal brush-border membrane.
Life sciences 2000;67(9):1047-58.
1999: Fumiko Higashikawa; Teruo Murakami; T Kaneda; Mikihisa Takano
In-vivo and in-vitro metabolic clearance of midazolam, a cytochrome P450 3A substrate, by the liver under normal and increased enzyme activity in rats.
The Journal of pharmacy and pharmacology 1999;51(4):405-10.
1999: Ryoko Yumoto; Teruo Murakami; Y Nakamoto; R Hasegawa; Junya Nagai; Mikihisa Takano
Transport of rhodamine 123, a P-glycoprotein substrate, across rat intestine and Caco-2 cell monolayers in the presence of cytochrome P-450 3A-related compounds.
The Journal of pharmacology and experimental therapeutics 1999;289(1):149-55.
1999: Tetsu Kajikawa; Hiromu K Mishima; Teruo Murakami; Mikihisa Takano
Role of P-glycoprotein in distribution of rhodamine 123 into aqueous humor in rabbits.
Current eye research 1999;18(3):240-6.
1999: N Katahira; Teruo Murakami; S Kugai; N Yata; Mikihisa Takano
Enhancement of topical delivery of a lipophilic drug from charged multilamellar liposomes.
Journal of drug targeting 1999;6(6):405-14.
1999: Fumiko Higashikawa; Teruo Murakami; T Kaneda; A Kato; Mikihisa Takano
Dose-dependent intestinal and hepatic first-pass metabolism of midazolam, a cytochrome P450 3A substrate with differently modulated enzyme activity in rats.
The Journal of pharmacy and pharmacology 1999;51(1):67-72.
1998: Mikihisa Takano; R Hasegawa; T Fukuda; Ryoko Yumoto; Junya Nagai; Teruo Murakami
Interaction with P-glycoprotein and transport of erythromycin, midazolam and ketoconazole in Caco-2 cells.
European journal of pharmacology 1998;358(3):289-94.
1998: M Kunihara; Junya Nagai; Teruo Murakami; Mikihisa Takano
Renal excretion of rhodamine 123, a P-glycoprotein substrate, in rats with glycerol-induced acute renal failure.
The Journal of pharmacy and pharmacology 1998;50(10):1161-5.
1998: Y Hashimoto; Teruo Murakami; C Kumasa; Y Higashi; N Yata; Mikihisa Takano
In-vivo calibration of microdialysis probe by use of endogenous glucose as an internal recovery marker: measurement of skin distribution of tranilast in rats.
The Journal of pharmacy and pharmacology 1998;50(6):621-6.
1998: Teruo Murakami; M Sato; Fumiko Higashikawa; A Okochi; Y Higashi; N Yata; Mikihisa Takano
Hepatic clearance of ONO-5046, a novel neutrophil elastase inhibitor, in rats and in the rat perfused liver.
The Journal of pharmacy and pharmacology 1998;50(4):425-30.