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Makoto Takano

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Makoto Takano; Hideyuki Kinoshita; Takao Shioya; Masayuki Itoh; Kazuwa Nakao; Koichiro Kuwahara
Pathophysiological remodeling of mouse cardiac myocytes expressing dominant negative mutant of neuron restrictive silencing factor.
Yasuaki Nakagawa; Koichiro Kuwahara; Genzou Takemura; Masaharu Akao; Masashi Kato; Yuji Arai; Makoto Takano; Masaki Harada; Masao Murakami; Michio Nakanishi; Satoru Usami; Shinji Yasuno; Hideyuki Kinoshita; Masataka Fujiwara; Kenji Ueshima; Kazuwa Nakao
p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.
Hideyuki Kinoshita; Koichiro Kuwahara; Makoto Takano; Yuji Arai; Yoshihiro Kuwabara; Shinji Yasuno; Yasuaki Nakagawa; Michio Nakanishi; Masaki Harada; Masataka Fujiwara; Masao Murakami; Kenji Ueshima; Kazuwa Nakao
T-type Ca2+ channel blockade prevents sudden death in mice with heart failure.

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All Publications

2010: Makoto Takano; Hideyuki Kinoshita; Takao Shioya; Masayuki Itoh; Kazuwa Nakao; Koichiro Kuwahara
Pathophysiological remodeling of mouse cardiac myocytes expressing dominant negative mutant of neuron restrictive silencing factor.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(12):2712-9.
2009: Yasuaki Nakagawa; Koichiro Kuwahara; Genzou Takemura; Masaharu Akao; Masashi Kato; Yuji Arai; Makoto Takano; Masaki Harada; Masao Murakami; Michio Nakanishi; Satoru Usami; Shinji Yasuno; Hideyuki Kinoshita; Masataka Fujiwara; Kenji Ueshima; Kazuwa Nakao
p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.
Circulation research 2009;105(8):746-54.
2009: Hideyuki Kinoshita; Koichiro Kuwahara; Makoto Takano; Yuji Arai; Yoshihiro Kuwabara; Shinji Yasuno; Yasuaki Nakagawa; Michio Nakanishi; Masaki Harada; Masataka Fujiwara; Masao Murakami; Kenji Ueshima; Kazuwa Nakao
T-type Ca2+ channel blockade prevents sudden death in mice with heart failure.
Circulation 2009;120(9):743-52.
2007: Kentoku Yanagi; Makoto Takano; Genta Narazaki; Hideki Uosaki; Takuhiro Hoshino; Takahiro Ishii; Takurou Misaki; Jun K Yamashita
Hyperpolarization-activated cyclic nucleotide-gated channels and T-type calcium channels confer automaticity of embryonic stem cell-derived cardiomyocytes.
Stem cells (Dayton, Ohio) 2007;25(11):2712-9.
2007: Shinobu Kuratomi; Akiko Kuratomi; Koichiro Kuwahara; Takahiro M Ishii; Kazuwa Nakao; Yoshihiko Saito; Makoto Takano
NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes.
Biochemical and biophysical research communications 2007;353(1):67-73.
2005: Takeru Makiyama; Masaharu Akao; Keiko Tsuji; Takahiro Doi; Seiko Ohno; Kotoe Takenaka; Atsushi Kobori; Tomonori Ninomiya; Hidetada Yoshida; Makoto Takano; Naomasa Makita; Fumiko Yanagisawa; Yukei Higashi; Youichi Takeyama; Toru Kita; Minoru Horie
High risk for bradyarrhythmic complications in patients with Brugada syndrome caused by SCN5A gene mutations.
Journal of the American College of Cardiology 2005;46(11):2100-6.
2005: Koichiro Kuwahara; Makoto Takano; Kazuwa Nakao
Pathophysiological significance of T-type Ca2+ channels: transcriptional regulation of T-type Ca2+ channel--regulation of CACNA1H by neuron-restrictive silencer factor.
Journal of pharmacological sciences 2005;99(3):211-3.
2005: Jun K Yamashita; Makoto Takano; Mina Hiraoka-Kanie; Chikashi Shimazu; Yan Peishi; Kentoku Yanagi; Akiko Nakano; Emi Inoue; Fumiyo Kita; Shin-Ichi Nishikawa
Prospective identification of cardiac progenitors by a novel single cell-based cardiomyocyte induction.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(11):1534-6.
2004: Atsushi Kobori; Nobuaki Sarai; Wataru Shimizu; Yoshihide Nakamura; Yosuke Murakami; Takeru Makiyama; Seiko Ohno; Kotoe Takenaka; Tomonori Ninomiya; Yuichiro Fujiwara; Satoshi Matsuoka; Makoto Takano; Akinori Noma; Toru Kita; Minoru Horie
Additional gene variants reduce effectiveness of beta-blockers in the LQT1 form of long QT syndrome.
Journal of cardiovascular electrophysiology 2004;15(2):190-9.
2003: Koichiro Kuwahara; Yoshihiko Saito; Makoto Takano; Yuji Arai; Shinji Yasuno; Yasuaki Nakagawa; Nobuki Takahashi; Yuichiro Adachi; Genzo Takemura; Minoru Horie; Yoshihiro Miyamoto; Takayuki Morisaki; Shinobu Kuratomi; Akinori Noma; Hisayoshi Fujiwara; Yasunao Yoshimasa; Hideyuki Kinoshita; Rika Kawakami; Ichiro Kishimoto; Michio Nakanishi; Satoru Usami; Yoshihiko Saito; Masaki Harada; Kazuwa Nakao
NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function.
The EMBO journal 2003;22(23):6310-21.
2003: Tomonori Ninomiya; Makoto Takano; Tetsuya Haruna; Yutaka Kono; Minoru Horie
Verapamil, a Ca2+ entry blocker, targets the pore-forming subunit of cardiac type KATP channel (Kir6.2).
Journal of cardiovascular pharmacology 2003;42(2):161-8.
2003: Makoto Takano; Shinobu Kuratomi
Regulation of cardiac inwardly rectifying potassium channels by membrane lipid metabolism.
Progress in biophysics and molecular biology 2003;81(1):67-79.
2002: Tetsuya Haruna; Hidetada Yoshida; Tomoe Y Nakamura; Lai-Hua Xie; Hideo Otani; Tomonori Ninomiya; Makoto Takano; William A Coetzee; Minoru Horie
Alpha1-adrenoceptor-mediated breakdown of phosphatidylinositol 4,5-bisphosphate inhibits pinacidil-activated ATP-sensitive K+ currents in rat ventricular myocytes.
Circulation research 2002;91(3):232-9.
2002: Tomoyuki Kubota; Minoru Horie; Makoto Takano; Hidetada Yoshida; Hideo Otani; Shigetake Sasayama
Role of KCNQ1 in the cell swelling-induced enhancement of the slowly activating delayed rectifier K(+) current.
The Japanese journal of physiology 2002;52(1):31-9.
2001: Takahiro M Ishii; Makoto Takano; Harunori Ohmori
Determinants of activation kinetics in mammalian hyperpolarization-activated cation channels.
The Journal of physiology 2001;537(Pt 1):93-100.
2001: Tomoyuki Kubota; Minoru Horie; Makoto Takano; Hidetada Yoshida; Kotoe Takenaka; E Watanabe; T Tsuchiya; Hideo Otani; Shigetake Sasayama
Evidence for a single nucleotide polymorphism in the KCNQ1 potassium channel that underlies susceptibility to life-threatening arrhythmias.
Journal of cardiovascular electrophysiology 2001;12(11):1223-9.
2000: Tetsuya Haruna; Minoru Horie; Makoto Takano; Yutaka Kono; Hiderou Yoshida; Hideo Otani; T Kubota; Tomonori Ninomiya; Masaharu Akao; Shigetake Sasayama
Alteration of the membrane lipid environment by L-palmitoylcarnitine modulates K(ATP) channels in guinea-pig ventricular myocytes.
Pflügers Archiv : European journal of physiology 2000;441(2-3):200-7.
2000: Masaharu Akao; T Sakurai; Minoru Horie; Hideo Otani; Makoto Takano; I Kouchi; Tomoaki Murakami; Shigetake Sasayama
Angiotensin II type 1 receptor blockade abolishes specific K(ATP)channel gene expression in rats with myocardial ischemia.
Journal of molecular and cellular cardiology 2000;32(12):2239-47.
2000: Yutaka Kono; Minoru Horie; Makoto Takano; Hideo Otani; Lai-Hua Xie; Masaharu Akao; Keiko Tsuji; Shigetake Sasayama
The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A.
Pflügers Archiv : European journal of physiology 2000;440(5):692-8.
1999: Lai-Hua Xie; Minoru Horie; Makoto Takano
Phospholipase C-linked receptors regulate the ATP-sensitive potassium channel by means of phosphatidylinositol 4,5-bisphosphate metabolism.
Proceedings of the National Academy of Sciences of the United States of America 1999;96(26):15292-7.
1999: Hidetada Yoshida; Minoru Horie; Hideo Otani; Makoto Takano; Keiko Tsuji; Tomoyuki Kubota; M Fukunami; Shigetake Sasayama
Characterization of a novel missense mutation in the pore of HERG in a patient with long QT syndrome.
Journal of cardiovascular electrophysiology 1999;10(9):1262-70.
1999: Lai-Hua Xie; Makoto Takano; M Kakei; M Okamura; Akinori Noma
Wortmannin, an inhibitor of phosphatidylinositol kinases, blocks the MgATP-dependent recovery of Kir6.2/SUR2A channels.
The Journal of physiology 1999;514 ( Pt 3)():655-65.
1998: Eri Mukai; H Ishida; Minoru Horie; Akinori Noma; Yutaka Seino; Makoto Takano
The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2.
Biochemical and biophysical research communications 1998;251(2):477-81.
1998: Makoto Takano; Lai-Hua Xie; Hideo Otani; Minoru Horie
Cytoplasmic terminus domains of Kir6.x confer different nucleotide-dependent gating on the ATP-sensitive K+ channel.
The Journal of physiology 1998;512 ( Pt 2)():395-406.
1998: K Takami; Hideyuki Saito; Masahiro Okuda; Makoto Takano; Ken Inui
Distinct characteristics of transcellular transport between nicotine and tetraethylammonium in LLC-PK1 cells.
The Journal of pharmacology and experimental therapeutics 1998;286(2):676-80.
1998: J Nagai; Ikuko Yano; Yukiya Hashimoto; Makoto Takano; Ken Inui
Efflux of intracellular alpha-ketoglutarate via p-aminohippurate/dicarboxylate exchange in OK kidney epithelial cells.
The Journal of pharmacology and experimental therapeutics 1998;285(2):422-7.
1998: Lai-Hua Xie; Makoto Takano; Akinori Noma
The inhibitory effect of propranolol on ATP-sensitive potassium channels in neonatal rat heart.
British journal of pharmacology 1998;123(4):599-604.
1997: Masaharu Akao; Hideo Otani; Minoru Horie; Makoto Takano; A Kuniyasu; H Nakayama; I Kouchi; Tomoaki Murakami; Shigetake Sasayama
Myocardial ischemia induces differential regulation of KATP channel gene expression in rat hearts.
The Journal of clinical investigation 1997;100(12):3053-9.
1997: J Nagai; Ikuko Yano; Yukiya Hashimoto; Makoto Takano; Ken Inui
Inhibition of PAH transport by parathyroid hormone in OK cells: involvement of protein kinase C pathway.
The American journal of physiology 1997;273(5 Pt 2):F674-9.
1997: Lai-Hua Xie; Makoto Takano; Akinori Noma
Development of inwardly rectifying K+ channel family in rat ventricular myocytes.
The American journal of physiology 1997;272(4 Pt 2):H1741-50.
1997: Makoto Takano; Akinori Noma
Development of muscarinic potassium current in fetal and neonatal rat heart.
The American journal of physiology 1997;272(3 Pt 2):H1188-95.
1996: Makoto Takano; T Ishii; Lai-Hua Xie
Cloning and functional expression of the rat brain KIR6.2 channel.
The Japanese journal of physiology 1996;46(6):491-5.
1996: T Nakamura; Makoto Takano; M Yasuhara; K Inui
In-vivo clearance study of vancomycin in rats.
The Journal of pharmacy and pharmacology 1996;48(11):1197-200.
1996: Tomo NABEKURA; Makoto Takano; K Inui
Cholesterol modulates organic cation transport activity and lipid fluidity in rat renal brush-border membranes.
Biochimica et biophysica acta 1996;1283(2):232-6.
1996: Yukiya Hashimoto; Y Otsuki; A Odani; Makoto Takano; Haruo Hattori; K Furusho; K Iui
Effect of CYP2C polymorphisms on the pharmacokinetics of phenytoin in Japanese patients with epilepsy.
Biological & pharmaceutical bulletin 1996;19(8):1103-5.
1996: Makoto Takano; J Nagai; M Yasuhara; K Inui
Regulation of p-aminohippurate transport by protein kinase C in OK kidney epithelial cells.
The American journal of physiology 1996;271(2 Pt 2):F469-75.
1996: Masahiro Okuda; H Saito; Yumiko Urakami; Makoto Takano; K Inui
cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2.
Biochemical and biophysical research communications 1996;224(2):500-7.
1996: Tomo NABEKURA; Makoto Takano; M Kimura; M Yasuhara; K Inui
Modulation of organic cation transport and lipid fluidity by benzyl alcohol in rat renal brush-border membranes.
Pharmaceutical research 1996;13(7):1069-72.
1996: A Odani; Yukiya Hashimoto; K Takayanagi; Y Otsuki; T Koue; Makoto Takano; M Yasuhara; Haruo Hattori; K Furusho; K Inui
Population pharmacokinetics of phenytoin in Japanese patients with epilepsy: analysis with a dose-dependent clearance model.
Biological & pharmaceutical bulletin 1996;19(3):444-8.
1995: K Manabe; Makoto Takano; Akinori Noma
Non-selective cation current of guinea-pig endocardial endothelial cells.
The Journal of physiology 1995;487 ( Pt 2)():407-19.
1995: J Nagai; Makoto Takano; K Hirozane; M Yasuhara; K Inui
Specificity of p-aminohippurate transport system in the OK kidney epithelial cell line.
The Journal of pharmacology and experimental therapeutics 1995;274(3):1161-6.
1995: M Kimura; Tomo NABEKURA; Toshiya Katsura; Makoto Takano; R Hori
Identification of organic cation transporter in rat renal brush-border membrane by photoaffinity labeling.
Biological & pharmaceutical bulletin 1995;18(3):388-95.
1995: Y Tomita; Makoto Takano; M Yasuhara; R Hori; K Inui
Transport of oral cephalosporins by the H+/dipeptide cotransporter and distribution of the transport activity in isolated rabbit intestinal epithelial cells.
The Journal of pharmacology and experimental therapeutics 1995;272(1):63-9.
1994: Makoto Takano; J Nagai; T Okano; K Hirozane; M Yasuhara; R Hori
Differential sensitivity of organic anion transporters in rat renal brush-border membrane to diethyl pyrocarbonate.
Biochimica et biophysica acta 1994;1192(2):190-6.
1994: F Maruoka; Y Nakashima; Makoto Takano; K Ono; Akinori Noma
Cation-dependent gating of the hyperpolarization-activated cation current in the rabbit sino-atrial node cells.
The Journal of physiology 1994;477 ( Pt 3)():423-35.
1994: Makoto Takano; K Hirozane; M Okamura; A Takayama; J Nagai; R Hori
p-Aminohippurate transport in apical and basolateral membranes of the OK kidney epithelial cells.
The Journal of pharmacology and experimental therapeutics 1994;269(3):970-5.
1994: Makoto Takano; Masahiro Okuda; M Yasuhara; R Hori
Cellular toxicity of aminoglycoside antibiotics in G418-sensitive and -resistant LLC-PK1 cells.
Pharmaceutical research 1994;11(5):609-15.
1994: Makoto Takano; Y Tomita; Toshiya Katsura; M Yasuhara; K Inui; R Hori
Bestatin transport in rabbit intestinal brush-border membrane vesicles.
Biochemical pharmacology 1994;47(6):1089-90.
1994: Makoto Takano; Y Ohishi; Masahiro Okuda; M Yasuhara; R Hori
Transport of gentamicin and fluid-phase endocytosis markers in the LLC-PK1 kidney epithelial cell line.
The Journal of pharmacology and experimental therapeutics 1994;268(2):669-74.
1993: Makoto Takano; Toshiya Katsura; Y Tomita; M Yasuhara; R Hori
Transport mechanism of choline in rat renal brush-border membrane.
Biological & pharmaceutical bulletin 1993;16(9):889-94.
1993: S Maeda; Makoto Takano; T Okano; K Ohoka; K Inui; R Hori
Transport of organic cation in renal brush-border membrane from rats with renal ischemic injury.
Biochimica et biophysica acta 1993;1150(2):103-10.
1993: R Hori; M Okamura; A Takayama; K Hirozane; Makoto Takano
Transport of organic anion in the OK kidney epithelial cell line.
The American journal of physiology 1993;264(6 Pt 2):F975-80.
1993: R Hori; Y Tomita; Toshiya Katsura; M Yasuhara; K Inui; Makoto Takano
Transport of bestatin in rat renal brush-border membrane vesicles.
Biochemical pharmacology 1993;45(9):1763-8.
1993: K Ohoka; Makoto Takano; T Okano; S Maeda; K Inui; R Hori
p-Aminohippurate transport in rat renal brush-border membranes: a potential-sensitive transport system and an anion exchanger.
Biological & pharmaceutical bulletin 1993;16(4):395-401.
1993: R Hori; Masahiro Okuda; Y Ohishi; M Yasuhara; K Inui; Makoto Takano
Decreased cellular toxicity of neomycin in a clonal cell line isolated from LLC-PK1.
Pharmaceutical research 1993;10(4):573-6.
1993: Toshiya Katsura; Makoto Takano; Y Tomita; M Yasuhara; K Inui; R Hori
Characteristics of organic cation transporter in rat renal basolateral membrane.
Biochimica et biophysica acta 1993;1146(2):197-202.
1992: Makoto Takano; M Kato; A Takayama; M Yasuhara; K Inui; R Hori
Transport of procainamide in a kidney epithelial cell line LLC-PK1.
Biochimica et biophysica acta 1992;1108(2):133-9.
1992: R Hori; Masahiro Okuda; Y Ohishi; M Yasuhara; Makoto Takano
Surface binding and intracellular uptake of gentamicin in the cultured kidney epithelial cell line (LLC-PK1).
The Journal of pharmacology and experimental therapeutics 1992;261(3):1200-5.
1992: R Hori; M Hirai; Toshiya Katsura; Makoto Takano; M Yasuhara; S Kaneko; M Satoh
Expression of renal organic cation transporter in Xenopus laevis oocytes.
The Biochemical journal 1992;283 ( Pt 2)():409-11.
1992: K Inui; Y Tomita; Toshiya Katsura; T Okano; Makoto Takano; R Hori
H+ coupled active transport of bestatin via the dipeptide transport system in rabbit intestinal brush-border membranes.
The Journal of pharmacology and experimental therapeutics 1992;260(2):482-6.
1991: Toshiya Katsura; H Maegawa; Y Tomita; Makoto Takano; K Inui; R Hori
Trans-stimulation effect on H(+)-organic cation antiport system in rat renal brush-border membranes.
The American journal of physiology 1991;261(5 Pt 2):F774-8.
1991: A Takayama; Y Okazaki; Kazuhiko Fukuda; Makoto Takano; K Inui; R Hori
Transport of cyclosporin A in kidney epithelial cell line (LLC-PK1).
The Journal of pharmacology and experimental therapeutics 1991;257(1):200-4.
1991: Akinori Noma; Makoto Takano
The ATP-sensitive K+ channel.
The Japanese journal of physiology 1991;41(2):177-87.
1990: Makoto Takano; D Y Qin; Akinori Noma
ATP-dependent decay and recovery of K+ channels in guinea pig cardiac myocytes.
The American journal of physiology 1990;258(1 Pt 2):H45-50.
1989: K Ishihara; Tamotsu Mitsuiye; Akinori Noma; Makoto Takano
The Mg2+ block and intrinsic gating underlying inward rectification of the K+ current in guinea-pig cardiac myocytes.
The Journal of physiology 1989;419():297-320.
1989: K Inui; Makoto Takano; H Maegawa; M Kato; R Hori
Decreased transport of p-aminohippurate in renal basolateral membranes isolated from rats with acute renal failure.
Pharmaceutical research 1989;6(11):954-7.
1989: Makoto Takano; T Okano; K Inui; R Hori
Transport of cephalosporin antibiotics in rat renal basolateral membranes.
The Journal of pharmacy and pharmacology 1989;41(11):795-6.
1988: K Inui; T Okano; H Maegawa; M Kato; Makoto Takano; R Hori
H+ coupled transport of p.o. cephalosporins via dipeptide carriers in rabbit intestinal brush-border membranes: difference of transport characteristics between cefixime and cephradine.
The Journal of pharmacology and experimental therapeutics 1988;247(1):235-41.