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Kozo Takayama

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TOP 3
Toru Nakamura; Takayuki Yamaji; Kozo Takayama
Effects of packaging and heat transfer kinetics on drug-product stability during storage under uncontrolled temperature conditions.
Atsuko Tomaru; Mariko Takeda-Morishita; Hirokazu Banba; Kozo Takayama
Analysis of the pharmacokinetic boosting effects of ritonavir on oral bioavailability of drugs in mice.
Akihito Yasuda; Rie Yamamoto; Yasuko Obata; Yoshinori Onuki; Kozo Takayama
Self-organizing map analysis using multivariate data from theophylline tablets predicted by a thin-plate spline interpolation.

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All Publications

2013: Toru Nakamura; Takayuki Yamaji; Kozo Takayama
Effects of packaging and heat transfer kinetics on drug-product stability during storage under uncontrolled temperature conditions.
Journal of pharmaceutical sciences 2013;102(5):1495-503.
2013: Atsuko Tomaru; Mariko Takeda-Morishita; Hirokazu Banba; Kozo Takayama
Analysis of the pharmacokinetic boosting effects of ritonavir on oral bioavailability of drugs in mice.
Drug metabolism and pharmacokinetics 2013;28(2):144-52.
2013: Akihito Yasuda; Rie Yamamoto; Yasuko Obata; Yoshinori Onuki; Kozo Takayama
Self-organizing map analysis using multivariate data from theophylline tablets predicted by a thin-plate spline interpolation.
Chemical & pharmaceutical bulletin 2013;61(3):304-9.
2013: Tadashi Norioka; Yoshinori Onuki; Hirotaka Andou; Yoshihiro Hayashi; Daisuke Tsunashima; Kazunari Yamashita; Kozo Takayama
A novel approach to establishing the design space for the oral formulation manufacturing process.
Chemical & pharmaceutical bulletin 2013;61(1):39-49.
2013: Atsuko Tomaru; Kozo Takayama; Takuya Fujita; Hiroyuki Kusuhara; Kazuya Maeda; Nozomi Morimoto; Mariko Morishita; Yuichi Sugiyama
Studies on the intestinal absorption characteristics of sulfasalazine, a breast cancer resistance protein (BCRP) substrate.
Drug metabolism and pharmacokinetics 2013;28(1):71-4.
2012: Yoshinori Onuki; Keisuke Takagaki; Hiroaki Arai; Shota Kawai; Jin Maeda; Kozo Takayama
Contribution of the physicochemical properties of active pharmaceutical ingredients to tablet properties identified by ensemble artificial neural networks and Kohonen's self-organizing maps.
Journal of pharmaceutical sciences 2012;101(7):2372-81.
2012: Sureewan Duangjit; Shingo Kikuchi; Yoshie Maitani; Tanasait Ngawhirunpat; Yasuko Obata; Yoshinori Onuki; Praneet Opanasopit; Hiromu Sano; Kozo Takayama
Menthosomes, novel ultradeformable vesicles for transdermal drug delivery: optimization and characterization.
Biological & pharmaceutical bulletin 2012;35(10):1720-8.
2012: Yoshihiro Hayashi; Jin Maeda; Yasuko Obata; Yoshinori Onuki; Etsuko Oshima; Kozo Takayama
Latent structure analysis of the process variables and pharmaceutical responses of an orally disintegrating tablet.
Chemical & pharmaceutical bulletin 2012;60(11):1419-25.
2012: Shingo Kikuchi; Hideto Kuribayashi; Yoshinori Onuki; Kozo Takayama
Relationship between diffusivity of water molecules inside hydrating tablets and their drug release behavior elucidated by magnetic resonance imaging.
Chemical & pharmaceutical bulletin 2012;60(4):536-42.
2012: Kazumi Ishitsuka; Yoshinori Onuki; Kozo Takayama
[Change in the drug release behavior of theophylline sustained-release tablets after division into two halves].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 2012;132(2):225-30.
2012: Yoshihiro Hayashi; Shingo Kikuchi; Yoshinori Onuki; Kozo Takayama
Reliability evaluation of nonlinear design space in pharmaceutical product development.
Journal of pharmaceutical sciences 2012;101(1):333-41.
2011: Yoshihiro Hayashi; Shingo Kikuchi; Kozo Takayama
Modeling of latent structure of indomethacin solid dispersion tablet using Bayesian networks.
Drug development and industrial pharmacy 2011;37(11):1290-7.
2011: Kozo Takayama; Akihiko Hirose; Atsushi Miyazaki; Masao Oguchi; Masako Onotogi; Ikuko Suda; Grigorios Fotopoulos
Comparison of the anti-inflammatory and analgesic effects in rats of diclofenac-sodium, felbinac and indomethacin patches.
International journal of biomedical science : IJBS 2011;7(3):222-9.
2011: Shingo Kikuchi; Yoshinori Onuki; Akihito Yasuda; Yoshihiro Hayashi; Kozo Takayama
Latent structure analysis in pharmaceutical formulations using Kohonen's self-organizing map and a Bayesian network.
Journal of pharmaceutical sciences 2011;100(3):964-75.
2011: Masato Nishikawa; Yoshinori Onuki; Yoshihide Okuno; Kozo Takayama
Impact of the state of water on the dispersion stability of a skin cream formulation elucidated by magnetic resonance techniques.
Chemical & pharmaceutical bulletin 2011;59(3):332-7.
2010: Hiroshi Watanabe; Yasuko Obata; Yoshinori Onuki; Kenya Ishida; Kozo Takayama
Different effects of l- and d-menthol on the microstructure of ceramide 5/cholesterol/palmitic acid bilayers.
International journal of pharmaceutics 2010;402(1-2):146-52.
2010: Akihito Yasuda; Yoshinori Onuki; Shingo Kikuchi; Kozo Takayama
Self-organizing map analysis using multivariate data from theophylline powders predicted by a thin-plate spline interpolation.
Journal of pharmaceutical sciences 2010;99(11):4535-42.
2010: Yasuko Obata; Yuriko Ashitaka; Shingo Kikuchi; Koichi Isowa; Kozo Takayama
A statistical approach to the development of a transdermal delivery system for ondansetron.
International journal of pharmaceutics 2010;399(1-2):87-93.
2010: Keisuke Takagaki; Hiroaki Arai; Kozo Takayama
Creation of a tablet database containing several active ingredients and prediction of their pharmaceutical characteristics based on ensemble artificial neural networks.
Journal of pharmaceutical sciences 2010;99(10):4201-14.
2010: Yoshinori Onuki; Shingo Kikuchi; Akihito Yasuda; Kozo Takayama
Role of individual test samples in optimal solutions in pharmaceuticals predicted using a nonlinear response surface method.
International journal of pharmaceutics 2010;396(1-2):75-82.
2010: Noriyasu Kamei; Mariko Morishita; Yousuke Kanayama; Koki Hasegawa; Mie Nishimura; Emi Hayashinaka; Yasuhiro Wada; Yasuyoshi Watanabe; Kozo Takayama
Molecular imaging analysis of intestinal insulin absorption boosted by cell-penetrating peptides by using positron emission tomography.
Journal of controlled release : official journal of the Controlled Release Society 2010;146(1):16-22.
2010: Masato Nishikawa; Yoshinori Onuki; Yoshihide Okuno; Kozo Takayama
Improving rheological characteristics of hydrophilic ointment base by treatment with a high-pressure wet-type jet mill.
Drug development and industrial pharmacy 2010;36(6):625-31.
2010: El-Sayed Khafagy; Mariko Morishita; Nobuo Ida; Reiji Nishio; Koichi Isowa; Kozo Takayama
Structural requirements of penetratin absorption enhancement efficiency for insulin delivery.
Journal of controlled release : official journal of the Controlled Release Society 2010;143(3):302-10.
2010: Yasuko Obata; Shunichi Utsumi; Hiroshi Watanabe; Masafumi Suda; Yoshihiro Tokudome; Makoto Otsuka; Kozo Takayama
Infrared spectroscopic study of lipid interaction in stratum corneum treated with transdermal absorption enhancers.
International journal of pharmaceutics 2010;389(1-2):18-23.
2010: El-Sayed Khafagy; Mariko Morishita; Kozo Takayama
The role of intermolecular interactions with penetratin and its analogue on the enhancement of absorption of nasal therapeutic peptides.
International journal of pharmaceutics 2010;388(1-2):209-12.
2010: Yoshinori Onuki; Kozo Takayama
Phase behavior in a ternary lipid membrane estimated using a nonlinear response surface method and Kohonen's self-organizing map.
Journal of colloid and interface science 2010;343(2):628-33.
2010: Hiroshi Watanabe; Yasuko Obata; Yoshinori Onuki; Kenya Ishida; Kozo Takayama
Novel preparation of intercellular lipid models of the stratum corneum containing stereoactive ceramide.
Chemical & pharmaceutical bulletin 2010;58(3):312-7.
2010: Shingo Kikuchi; Kozo Takayama
Multivariate statistical approach to optimizing sustained-release tablet formulations containing diltiazem hydrochloride as a model highly water-soluble drug.
International journal of pharmaceutics 2010;386(1-2):149-55.
2010: Yasuko Obata; Yuki Otake; Kozo Takayama
Feasibility of transdermal delivery of prochlorperazine.
Biological & pharmaceutical bulletin 2010;33(8):1454-7.
2009: El-Sayed Khafagy; Mariko Morishita; Noriyasu Kamei; Yoshimi Eda; Yohei Ikeno; Kozo Takayama
Efficiency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins.
International journal of pharmaceutics 2009;381(1):49-55.
2009: Hiroshi Watanabe; Yasuko Obata; Kenya Ishida; Kozo Takayama
Effect of l-menthol on the thermotropic behavior of ceramide 2/cholesterol mixtures as a model for the intercellular lipids in stratum corneum.
Colloids and surfaces. B, Biointerfaces 2009;73(1):116-21.
2009: Noriyasu Kamei; Mariko Morishita; Kozo Takayama
Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides.
Journal of controlled release : official journal of the Controlled Release Society 2009;136(3):179-86.
2009: Shingo Kikuchi; Kozo Takayama
Reliability assessment for the optimal formulations of pharmaceutical products predicted by a nonlinear response surface method.
International journal of pharmaceutics 2009;374(1-2):5-11.
2009: F Yanagawa; Y Onuki; Mariko Morishita; Kozo Takayama
Prediction of permeability of FD-4 through porous poly (2-hydroxyethyl methacrylate) membrane by multiple linear regression and artificial neural network.
Die Pharmazie 2009;64(5):311-5.
2009: Tetsuo Yamagata; Mariko Morishita; Hiroyuki Kusuhara; Kozo Takayama; Hassan Benameur; Yuichi Sugiyama
Characterization of the inhibition of breast cancer resistance protein-mediated efflux of mitoxantrone by pharmaceutical excipients.
International journal of pharmaceutics 2009;370(1-2):216-9.
2009: Noriyasu Kamei; Mariko Morishita; Hitomi Chiba; Nikhil J Kavimandan; Nicholas A Peppas; Kozo Takayama
Complexation hydrogels for intestinal delivery of interferon beta and calcitonin.
Journal of controlled release : official journal of the Controlled Release Society 2009;134(2):98-102.
2009: Ko Sugibayashi; Yoshinori Onuki; Kozo Takayama
Displacement of tight junction proteins from detergent-resistant membrane domains by treatment with sodium caprate.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2009;36(2-3):246-53.
2008: Mariko Morishita; Tomohiro Tanaka; Takayuki Shida; Kozo Takayama
Usefulness of colon targeted DHA and EPA as novel diabetes medications that promote intrinsic GLP-1 secretion.
Journal of controlled release : official journal of the Controlled Release Society 2008;132(2):99-104.
2008: Noriyasu Kamei; Mariko Morishita; Yoshimi Eda; Nobuo Ida; Reiji Nishio; Kozo Takayama
Usefulness of cell-penetrating peptides to improve intestinal insulin absorption.
Journal of controlled release : official journal of the Controlled Release Society 2008;132(1):21-5.
2008: Noriyasu Kamei; Mariko Morishita; Jumpei Ehara; Kozo Takayama
Permeation characteristics of oligoarginine through intestinal epithelium and its usefulness for intestinal peptide drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 2008;131(2):94-9.
2008: Yoshinori Onuki; Chihiro Hagiwara; Ko Sugibayashi; Kozo Takayama
Specific effect of polyunsaturated fatty acids on the cholesterol-poor membrane domain in a model membrane.
Chemical & pharmaceutical bulletin 2008;56(8):1103-9.
2008: F Yanagawa; Y Ishii; Yoshinori Onuki; Mariko Morishita; Kozo Takayama
Factors affecting release rate of diltiazem hydrochloride from poly (2-hydroxyethyl methacrylate) matrices.
Colloids and surfaces. B, Biointerfaces 2008;63(1):146-52.
2008: Masafumi Suda; Kozo Takayama; Makoto Otsuka
An accurate quantitative analysis of polymorphic content by chemometric X-ray powder diffraction.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 2008;24(4):451-7.
2008: Yoshinori Onuki; Masato Nishikawa; Mariko Morishita; Kozo Takayama
Development of photocrosslinked polyacrylic acid hydrogel as an adhesive for dermatological patches: involvement of formulation factors in physical properties and pharmacological effects.
International journal of pharmaceutics 2008;349(1-2):47-52.
2008: Masato Nishikawa; Yoshinori Onuki; Koichi Isowa; Kozo Takayama
Formulation optimization of an indomethacin-containing photocrosslinked polyacrylic acid hydrogel as an anti-inflammatory patch.
AAPS PharmSciTech 2008;9(3):1038-45.
2008: Yoshinori Onuki; Koichi Ohyama; Chosei Kaseda; Hiroaki Arai; Tatsuya Suzuki; Kozo Takayama
Evaluation of the reliability of nonlinear optimal solutions in pharmaceuticals using a bootstrap resampling technique in combination with Kohonen's self-organizing maps.
Journal of pharmaceutical sciences 2008;97(1):331-9.
2007: El-Sayed Khafagy; Mariko Morishita; Yoshinori Onuki; Kozo Takayama
Current challenges in non-invasive insulin delivery systems: a comparative review.
Advanced drug delivery reviews 2007;59(15):1521-46.
2007: Tetsuo Yamagata; Hiroyuki Kusuhara; Mariko Morishita; Kozo Takayama; Hassan Benameur; Yuichi Sugiyama
Effect of excipients on breast cancer resistance protein substrate uptake activity.
Journal of controlled release : official journal of the Controlled Release Society 2007;124(1-2):1-5.
2007: Chikako Takeda; Yuri Takahashi; Isamu Seto; Genji Kawano; Kozo Takayama; Hiraku Onishi; Yoshiharu Machida
Influence of pectins on preparation characteristics of lactoferrin bioadhesive tablets.
Chemical & pharmaceutical bulletin 2007;55(8):1164-8.
2007: Tetsuo Yamagata; Hiroyuki Kusuhara; Mariko Morishita; Kozo Takayama; Hassan Benameur; Yuichi Sugiyama
Improvement of the oral drug absorption of topotecan through the inhibition of intestinal xenobiotic efflux transporter, breast cancer resistance protein, by excipients.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(7):1142-8.
2007: Mariko Morishita; Noriyasu Kamei; Jumpei Ehara; Koichi Isowa; Kozo Takayama
A novel approach using functional peptides for efficient intestinal absorption of insulin.
Journal of controlled release : official journal of the Controlled Release Society 2007;118(2):177-84.
2006: Yasuko Obata; Ichiro Hatta; Noboru Ohta; Naomi Kunizawa; Naoto Yagi; Kozo Takayama
Combined effects of ethanol and L-menthol on hairless rat stratum corneum investigated by synchrotron X-ray diffraction.
Journal of controlled release : official journal of the Controlled Release Society 2006;115(3):275-9.
2006: Tetsuo Yamagata; Mariko Morishita; Nikhil J Kavimandan; Koji Nakamura; Yu Fukuoka; Kozo Takayama; Nicholas A Peppas
Characterization of insulin protection properties of complexation hydrogels in gastric and intestinal enzyme fluids.
Journal of controlled release : official journal of the Controlled Release Society 2006;112(3):343-9.
2006: Mariko Morishita; Takahiro Goto; Koji Nakamura; Anthony Lowman; Kozo Takayama; Nicholas A Peppas
Novel oral insulin delivery systems based on complexation polymer hydrogels: single and multiple administration studies in type 1 and 2 diabetic rats.
Journal of controlled release : official journal of the Controlled Release Society 2006;110(3):587-94.
2006: Yasuko Obata; Yoshimichi Maruyama; Kozo Takayama
The mode of promoting activity of O-ethylmenthol as a transdermal absorption enhancer.
Pharmaceutical research 2006;23(2):392-400.
2006: Takahiro Goto; Mariko Morishita; Ken Nishimura; Mahito Nakanishi; Atsushi Kato; Jumpei Ehara; Kozo Takayama
Novel mucosal insulin delivery systems based on fusogenic liposomes.
Pharmaceutical research 2006;23(2):384-91.
2006: Takahiro Goto; Mariko Morishita; Nikhil J Kavimandan; Kozo Takayama; Nicholas A Peppas
Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats.
Journal of pharmaceutical sciences 2006;95(2):462-9.
2006: Fumiki Yanagawa; Yoshinori Onuki; Mariko Morishita; Kozo Takayama
Involvement of fractal geometry on solute permeation through porous poly (2-hydroxyethyl methacrylate) membranes.
Journal of controlled release : official journal of the Controlled Release Society 2006;110(2):395-9.
2006: Yoshinori Onuki; Mariko Morishita; Yoshiyuki Chiba; Shinji Tokiwa; Kozo Takayama
Docosahexaenoic acid and eicosapentaenoic acid induce changes in the physical properties of a lipid bilayer model membrane.
Chemical & pharmaceutical bulletin 2006;54(1):68-71.
2005: Yoshinori Onuki; Masaru Hoshi; Hideaki Okabe; Mikito Fujikawa; Mariko Morishita; Kozo Takayama
Formulation optimization of photocrosslinked polyacrylic acid modified with 2-hydroxyethyl methacrylate hydrogel as an adhesive for a dermatological patch.
Journal of controlled release : official journal of the Controlled Release Society 2005;108(2-3):331-40.
2005: Yoshinobu Aoki; Mariko Morishita; Kazunori Asai; Bunshiro Akikusa; Shuji Hosoda; Kozo Takayama
Region-dependent role of the mucous/glycocalyx layers in insulin permeation across rat small intestinal membrane.
Pharmaceutical research 2005;22(11):1854-62.
2005: Yoshinobu Aoki; Mariko Morishita; Kozo Takayama
Role of the mucous/glycocalyx layers in insulin permeation across the rat ileal membrane.
International journal of pharmaceutics 2005;297(1-2):98-109.
2004: Mariko Morishita; Takahiro Goto; Nicholas A Peppas; Jeffrey I Joseph; Marc C Torjman; Carey Munsick; Koji Nakamura; Tetsuo Yamagata; Kozo Takayama; Anthony Lowman
Mucosal insulin delivery systems based on complexation polymer hydrogels: effect of particle size on insulin enteral absorption.
Journal of controlled release : official journal of the Controlled Release Society 2004;97(1):115-24.
2004: Yoshinori Onuki; Mariko Morishita; Kozo Takayama
Formulation optimization of water-in-oil-water multiple emulsion for intestinal insulin delivery.
Journal of controlled release : official journal of the Controlled Release Society 2004;97(1):91-9.
2004: Kozo Takayama; Yasuko Obata; Mariko Morishita; Tsuneji Nagai
Multivariate spline interpolation as a novel method to optimize pharmaceutical formulations.
Die Pharmazie 2004;59(5):392-5.
2004: Takahiro Nagamoto; Yoshiyuki Hattori; Kozo Takayama; Yoshie Maitani
Novel chitosan particles and chitosan-coated emulsions inducing immune response via intranasal vaccine delivery.
Pharmaceutical research 2004;21(4):671-4.
2004: Mariko Morishita; Yoshinobu Aoki; Masahiro Sakagami; Tsuneji Nagai; Kozo Takayama
In situ ileal absorption of insulin in rats: effects of hyaluronidase pretreatment diminishing the mucous/glycocalyx layers.
Pharmaceutical research 2004;21(2):309-16.
2003: Esti Hendradi; Yasuko Obata; Koichi Isowa; Tsuneji Nagai; Kozo Takayama
Effect of mixed micelle formulations including terpenes on the transdermal delivery of diclofenac.
Biological & pharmaceutical bulletin 2003;26(12):1739-43.
2003: Kozo Takayama; Mikito Fujikawa; Yasuko Obata; Mariko Morishita
Neural network based optimization of drug formulations.
Advanced drug delivery reviews 2003;55(9):1217-31.
2003: Silvia Surini; Hidero Akiyama; Mariko Morishita; Tsuneji Nagai; Kozo Takayama
Release phenomena of insulin from an implantable device composed of a polyion complex of chitosan and sodium hyaluronate.
Journal of controlled release : official journal of the Controlled Release Society 2003;90(3):291-301.
2003: Chao Jie Li; Yasuko Obata; Kimio Higashiyama; Tsuneji Nagai; Kozo Takayama
Effect of 1-O-ethyl-3-butylcyclohexanol on the skin permeation of drugs with different physicochemical characteristics.
International journal of pharmaceutics 2003;259(1-2):193-8.
2003: Kazuyuki Shimizu; Kayoko Tamagawa; Noriko Takahashi; Kozo Takayama; Yoshie Maitani
Stability and antitumor effects of all-trans retinoic acid-loaded liposomes contained sterylglucoside mixture.
International journal of pharmaceutics 2003;258(1-2):45-53.
2003: Kumi Kawano; Kozo Takayama; Tsuneji Nagai; Yoshie Maitani
Preparation and pharmacokinetics of pirarubicin loaded dehydration-rehydration vesicles.
International journal of pharmaceutics 2003;252(1-2):73-9.
2003: Koji Nakamura; Kozo Takayama; Tsuneji Nagai; Yoshie Maitani
Regional intestinal absorption of FITC-dextran 4,400 with nanoparticles based on beta-sitosterol beta-D-glucoside in rats.
Journal of pharmaceutical sciences 2003;92(2):311-8.
2003: Wang Junping; Kozo Takayama; Tsuneji Nagai; Yoshie Maitani
Pharmacokinetics and antitumor effects of vincristine carried by microemulsions composed of PEG-lipid, oleic acid, vitamin E and cholesterol.
International journal of pharmaceutics 2003;251(1-2):13-21.
2002: Mariko Morishita; Kozo Takayama
[The design of oral insulin delivery systems based on smart hydrogels].
Nihon rinsho. Japanese journal of clinical medicine 2002;60 Suppl 9():516-21.
2002: Kumi Kawano; Kouji Nakamura; Kyoko Hayashi; Tsuneji Nagai; Kozo Takayama; Yoshie Maitani
Liver targeting liposomes containing beta-sitosterol glucoside with regard to penetration-enhancing effect on HepG2 cells.
Biological & pharmaceutical bulletin 2002;25(6):766-70.
2002: Mariko Morishita; Anthony Lowman; Kozo Takayama; Tsuneji Nagai; Nicholas A Peppas
Elucidation of the mechanism of incorporation of insulin in controlled release systems based on complexation polymers.
Journal of controlled release : official journal of the Controlled Release Society 2002;81(1-2):25-32.
2002: Keiko Tsutsumi; Yasuko Obata; Tsuneji Nagai; Thorsteinn Loftsson; Kozo Takayama
Buccal absorption of ergotamine tartrate using the bioadhesive tablet system in guinea-pigs.
International journal of pharmaceutics 2002;238(1-2):161-70.
2002: Junping Wang; Yoshie Maitani; Kozo Takayama
Antitumor effects and pharmacokinetics of aclacinomycin A carried by injectable emulsions composed of vitamin E, cholesterol, and PEG-lipid.
Journal of pharmaceutical sciences 2002;91(4):1128-34.
2002: Kouji Nakamura; Yoshie Maitani; Kozo Takayama
The enhancing effect of nasal absorption of FITC-dextran 4,400 by beta-sitosterol beta-D-glucoside in rabbits.
Journal of controlled release : official journal of the Controlled Release Society 2002;79(1-3):147-55.
2002: Jun-Ichi Sudo; Hiroaki Iwase; Kimio Higashiyama; Katsuhiko Kakuno; Fumiji Miyasaka; Takashi Meguro; Kozo Takayama
Elevation of plasma levels of L-dopa in transdermal administration of L-dopa-butylester in rats.
Drug development and industrial pharmacy 2002;28(1):59-65.
2001: M Iwata; S Komiya; Kouji Nakamura; M Kiuchi; N Andoh; Fumiki Hirahara; Yoshie Maitani; Kozo Takayama
Release property of progesterone from a mixed-base suppository consisting of Witepsol W35 and Witepsol E85.
Drug development and industrial pharmacy 2001;27(10):1039-45.
2001: Mariko Morishita; Kozo Takayama
[Application of pH-responsive polymers to oral dosage forms for insulin].
Nihon rinsho. Japanese journal of clinical medicine 2001;59(11):2255-60.
2001: Chao Jie Li; Kimio Higashiyama; Yoshihiro Yoshimura; Tsuneji Nagai; Kozo Takayama; Yasuko Obata
Promoting mechanism of menthol derivative, 1-O-ethyl-3-buthylcyclohexanol, on the percutaneous absorption of ketoprofen.
Biological & pharmaceutical bulletin 2001;24(9):1044-8.
2001: Yoshie Maitani; Kumi Kawano; K Yamada; Tsuneji Nagai; Kozo Takayama
Efficiency of liposomes surface-modified with soybean-derived sterylglucoside as a liver targeting carrier in HepG2 cells.
Journal of controlled release : official journal of the Controlled Release Society 2001;75(3):381-9.
2001: P C Wu; Yasuko Obata; Mikito Fujikawa; Chao Jie Li; Kimio Higashiyama; Kozo Takayama
Simultaneous optimization based on artificial neural networks in ketoprofen hydrogel formula containing O-ethyl-3-butylcyclohexanol as percutaneous absorption enhancer.
Journal of pharmaceutical sciences 2001;90(8):1004-14.
2001: S H Hwang; Kyoko Hayashi; Kozo Takayama; Yoshie Maitani
Liver-targeted gene transfer into a human hepatoblastoma cell line and in vivo by sterylglucoside-containing cationic liposomes.
Gene therapy 2001;8(16):1276-80.
2001: Mariko Morishita; JM Barichello; Kozo Takayama; Yoshiyuki Chiba; Shinji Tokiwa; Tsuneji Nagai
Pluronic F-127 gels incorporating highly purified unsaturated fatty acids for buccal delivery of insulin.
International journal of pharmaceutics 2001;212(2):289-93.
2001: Yasuko Obata; Chao Jie Li; Mikito Fujikawa; Kozo Takayama; H Sato; Kimio Higashiyama; Koichi Isowa; Tsuneji Nagai
Evaluation and structure-activity relationship of synthesized cyclohexanol derivatives on percutaneous absorption of ketoprofen using artificial neural network.
International journal of pharmaceutics 2001;212(2):223-31.
2001: Yoshie Maitani; H Soeda; W Junping; Kozo Takayama
MODIFIED ETHANOL INJECTION METHOD FOR LIPOSOMES CONTAINING beta-SITOSTEROL beta-D-GLUCOSIDE.
Journal of liposome research 2001;11(1):115-25.
2000: M Kajita; Mariko Morishita; Kozo Takayama; Yoshiyuki Chiba; Shinji Tokiwa; Tsuneji Nagai
Enhanced enteral bioavailability of vancomycin using water-in-oil-in-water multiple emulsion incorporating highly purified unsaturated fatty acid.
Journal of pharmaceutical sciences 2000;89(10):1243-52.
2000: W Junping; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
In vivo evaluation of doxorubicin carried with long circulating and remote loading proliposome.
International journal of pharmaceutics 2000;203(1-2):61-9.
2000: Kozo Takayama; A Morva; Mikito Fujikawa; Yoshiyuki Hattori; Yasuko Obata; Tsuneji Nagai
Formula optimization of theophylline controlled-release tablet based on artificial neural networks.
Journal of controlled release : official journal of the Controlled Release Society 2000;68(2):175-86.
2000: J P Wang; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
Pharmacokinetics and antitumor effect of doxorubicin carried by stealth and remote loading proliposome.
Pharmaceutical research 2000;17(7):782-7.
2000: Hiroaki Iwase; Jun-Ichi Sudo; J Terui; Katsuhiko Kakuno; T Watanabe; Kozo Takayama; Tsuneji Nagai
Transdermal absorption of L-dopa from a new system composed of two separate layers of L-dopa and hydrogel in rats.
Drug development and industrial pharmacy 2000;26(7):755-9.
2000: Mariko Morishita; M Kajita; A Suzuki; Kozo Takayama; Yoshiyuki Chiba; Shinji Tokiwa; Tsuneji Nagai
The dose-related hypoglycemic effects of insulin emulsions incorporating highly purified EPA and DHA.
International journal of pharmaceutics 2000;201(2):175-85.
2000: K Muramatsu; T Masumizu; Yoshie Maitani; SH Hwang; M Kohno; Kozo Takayama; Tsuneji Nagai
Electron spin resonance studies of dipalmitoylphosphatidylcholine liposomes containing soybean-derived sterylglucoside.
Chemical & pharmaceutical bulletin 2000;48(5):610-3.
2000: Yoshie Maitani; Kouji Nakamura; Hiroshi Suenaga; Katsuo Kamata; Kozo Takayama; Tsuneji Nagai
The enhancing effect of soybean-derived sterylglucoside and beta-sitosterol beta-D-glucoside on nasal absorption in rabbits.
International journal of pharmaceutics 2000;200(1):17-26.
2000: Yasuko Obata; H Sato; Chao Jie Li; Kozo Takayama; Kimio Higashiyama; Tsuneji Nagai; Koichi Isowa
Effect of synthesized cyclohexanol derivatives using L-menthol as a lead compound on the percutaneous absorption of ketoprofen.
International journal of pharmaceutics 2000;198(2):191-200.
2000: Yoshinori Onuki; Mariko Morishita; Kozo Takayama; Shinji Tokiwa; Yoshiyuki Chiba; Koichi Isowa; Tsuneji Nagai
In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption.
International journal of pharmaceutics 2000;198(2):147-56.
2000: Yasuko Obata; T Sesumi; Kozo Takayama; Koichi Isowa; S Grosh; S Wick; R Sitz; Tsuneji Nagai
Evaluation of skin damage caused by percutaneous absorption enhancers using fractal analysis.
Journal of pharmaceutical sciences 2000;89(4):556-61.
2000: SH Hwang; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
High entrapment of insulin and bovine serum albumin into neutral and positively-charged liposomes by the remote loading method.
Chemical & pharmaceutical bulletin 2000;48(3):325-9.
1999: Kozo Takayama; J Takahara; Mikito Fujikawa; H Ichikawa; Tsuneji Nagai
Formula optimization based on artificial neural networks in transdermal drug delivery.
Journal of controlled release : official journal of the Controlled Release Society 1999;62(1-2):161-70.
1999: K Muramatsu; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
The relationship between the rigidity of the liposomal membrane and the absorption of insulin after nasal administration of liposomes modified with an enhancer containing insulin in rabbits.
Drug development and industrial pharmacy 1999;25(10):1099-105.
1999: Kouji Nakamura; Yoshie Maitani; Anthony Lowman; Kozo Takayama; Nicholas A Peppas; Tsuneji Nagai
Uptake and release of budesonide from mucoadhesive, pH-sensitive copolymers and their application to nasal delivery.
Journal of controlled release : official journal of the Controlled Release Society 1999;61(3):329-35.
1999: Yoshie Maitani; H Moriya; N Shimoda; Kozo Takayama; Tsuneji Nagai
Distribution characteristics of entrapped recombinant human erythropoietin in liposomes and its intestinal absorption in rats.
International journal of pharmaceutics 1999;185(1):13-22.
1999: JM Barichello; Mariko Morishita; Kozo Takayama; Tsuneji Nagai
Absorption of insulin from pluronic F-127 gels following subcutaneous administration in rats.
International journal of pharmaceutics 1999;184(2):189-98.
1999: JM Barichello; Mariko Morishita; Kozo Takayama; Yoshiyuki Chiba; Shinji Tokiwa; Tsuneji Nagai
Enhanced rectal absorption of insulin-loaded Pluronic F-127 gels containing unsaturated fatty acids.
International journal of pharmaceutics 1999;183(2):125-32.
1999: JM Barichello; Mariko Morishita; Kozo Takayama; Tsuneji Nagai
Encapsulation of hydrophilic and lipophilic drugs in PLGA nanoparticles by the nanoprecipitation method.
Drug development and industrial pharmacy 1999;25(4):471-6.
1999: SH Hwang; Yoshie Maitani; Xian-rong Qi; Kozo Takayama; Tsuneji Nagai
Remote loading of diclofenac, insulin and fluorescein isothiocyanate labeled insulin into liposomes by pH and acetate gradient methods.
International journal of pharmaceutics 1999;179(1):85-95.
1999: Keiko Tsutsumi; Yasuko Obata; Kozo Takayama; Koichi Isowa; Tsuneji Nagai
Permeation of several drugs through keratinized epithelial-free membrane of hamster cheek pouch.
International journal of pharmaceutics 1999;177(1):7-14.
1999: Y Takanashi; Kimio Higashiyama; H Komiya; Kozo Takayama; Tsuneji Nagai
Thiomenthol derivatives as novel percutaneous absorption enhancers.
Drug development and industrial pharmacy 1999;25(1):89-94.
1999: Kozo Takayama; Mikito Fujikawa; Tsuneji Nagai
Artificial neural network as a novel method to optimize pharmaceutical formulations.
Pharmaceutical research 1999;16(1):1-6.
1998: Jun-Ichi Sudo; Hiroaki Iwase; J Terui; Katsuhiko Kakuno; M Soyama; Kozo Takayama; Tsuneji Nagai
Transdermal absorption of L-dopa from hydrogel in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 1998;7(1):67-71.
1998: A Suzuki; Mariko Morishita; M Kajita; Kozo Takayama; Koichi Isowa; Yoshiyuki Chiba; Shinji Tokiwa; Tsuneji Nagai
Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid.
Journal of pharmaceutical sciences 1998;87(10):1196-202.
1998: Keiko Tsutsumi; Yasuko Obata; Kozo Takayama; Thorsteinn Loftsson; Tsuneji Nagai
Effect of cod-liver oil extract on the buccal permeation of ergotamine tartrate.
Drug development and industrial pharmacy 1998;24(8):757-62.
1998: T Yamamoto; Yoshie Maitani; T Ando; Koichi Isowa; Kozo Takayama; Tsuneji Nagai
High absorbency and subchronic morphologic effects on the nasal epithelium of a nasal insulin powder dosage form with a soybean-derived sterylglucoside mixture in rabbits.
Biological & pharmaceutical bulletin 1998;21(8):866-70.
1998: T Ando; Yoshie Maitani; T Yamamoto; Kozo Takayama; Tsuneji Nagai
Nasal insulin delivery in rabbits using soybean-derived sterylglucoside and sterol mixtures as novel enhancers in suspension dosage forms.
Biological & pharmaceutical bulletin 1998;21(8):862-5.
1998: Kazuyuki Shimizu; Yoshie Maitani; Noriko Takahashi; Kozo Takayama; Tsuneji Nagai
Association of liposomes containing a soybean-derived sterylglucoside mixture with rat primary cultured hepatocytes.
Biological & pharmaceutical bulletin 1998;21(8):818-22.
1998: Kazuyuki Shimizu; Xian-rong Qi; Yoshie Maitani; M Yoshii; Kumi Kawano; Kozo Takayama; Tsuneji Nagai
Targeting of soybean-derived sterylglucoside liposomes to liver tumors in rat and mouse models.
Biological & pharmaceutical bulletin 1998;21(7):741-6.
1998: S Yamane; Kozo Takayama; Tsuneji Nagai
Effect of fractal dimension on drug permeation through porous ethylcellulose films.
Journal of controlled release : official journal of the Controlled Release Society 1998;50(1-3):103-9.
1997: H Moriya; Yoshie Maitani; N Shimoda; Kozo Takayama; Tsuneji Nagai
Pharmacokinetic and pharmacological profiles of free and liposomal recombinant human erythropoietin after intravenous and subcutaneous administrations in rats.
Pharmaceutical research 1997;14(11):1621-8.
1997: Kazuyuki Shimizu; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
Formulation of liposomes with a soybean-derived sterylglucoside mixture and cholesterol for liver targeting.
Biological & pharmaceutical bulletin 1997;20(8):881-6.
1996: Kazuyuki Shimizu; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
Characterization of dipalmitoylphosphatidylcholine liposomes containing a soybean-derived sterylglucoside mixture by differential scanning calorimetry, Fourier transform infrared spectroscopy, and enzymatic assay.
Journal of pharmaceutical sciences 1996;85(7):741-4.
1996: Kazuyuki Shimizu; Yoshie Maitani; Kozo Takayama; Tsuneji Nagai
Evaluation of dipalmitoylphosphatidylcholine liposomes containing a soybean-derived sterylglucoside mixture for liver targeting.
Journal of drug targeting 1996;4(4):245-53.
1995: A Matsuzawa; M Morishita; Kozo Takayama; Tsuneji Nagai
Absorption of insulin using water-in-oil-in-water emulsion from an enteral loop in rats.
Biological & pharmaceutical bulletin 1995;18(12):1718-23.
1995: N Ohara; Kozo Takayama; Tsuneji Nagai
Combined effect of d-limonene pretreatment and temperature on the rat skin permeation of lipophilic and hydrophilic drugs.
Biological & pharmaceutical bulletin 1995;18(3):439-42.
1994: K K Levison; Kozo Takayama; Koichi Isowa; K Okabe; Tsuneji Nagai
Formulation optimization of indomethacin gels containing a combination of three kinds of cyclic monoterpenes as percutaneous penetration enhancers.
Journal of pharmaceutical sciences 1994;83(9):1367-72.
1993: M Kitahara; F Ishiguro; Kozo Takayama; Koichi Isowa; Tsuneji Nagai
Evaluation of skin damage of cyclic monoterpenes, percutaneous absorption enhancers, by using culture human skin cells.
Biological & pharmaceutical bulletin 1993;16(9):912-6.
1993: Y Obata; Kozo Takayama; Yoshie Maitani; Yoshiharu Machida; Tsuneji Nagai
Effect of pretreatment of skin with cyclic monoterpenes on permeation of diclofenac in hairless rat.
Biological & pharmaceutical bulletin 1993;16(3):312-4.
1993: M Morishita; I Morishita; Kozo Takayama; Yoshiharu Machida; Tsuneji Nagai
Site-dependent effect of aprotinin, sodium caprate, Na2EDTA and sodium glycocholate on intestinal absorption of insulin.
Biological & pharmaceutical bulletin 1993;16(1):68-72.
1992: K Kikuchi; Kozo Takayama; Tsuneji Nagai
Effect of d-limonene on the amounts of ethanol and indomethacin penetrated from aqueous gel ointments to rat skin.
Chemical & pharmaceutical bulletin 1992;40(11):3108-9.
1992: J Príborský; Kozo Takayama; Z Príborská; E Mühlbachová; Tsuneji Nagai
The influence of detergents on skin barrier properties.
Pharmacology & toxicology 1992;70(5 Pt 1):344-6.
1992: M Hirata; Kozo Takayama; Tsuneji Nagai
Formulation optimization of sustained-release tablet of chlorpheniramine maleate by means of extreme vertices design and simultaneous optimization technique.
Chemical & pharmaceutical bulletin 1992;40(3):741-6.
1992: J Priborský; Kozo Takayama; Y Obata; Z Príborská; Tsuneji Nagai
Influence of limonene and laurocapram on percutaneous absorption of nonsteroidal anti-inflammatory drugs.
Arzneimittel-Forschung 1992;42(2):116-9.
1991: Y Obata; Kozo Takayama; Yoshiharu Machida; Tsuneji Nagai
Combined effect of cyclic monoterpenes and ethanol on percutaneous absorption of diclofenac sodium.
Drug design and discovery 1991;8(2):137-44.
1990: Y Obata; Kozo Takayama; H Okabe; Tsuneji Nagai
Effect of cyclic monoterpenes on percutaneous absorption in the case of a water-soluble drug (diclofenac sodium).
Drug design and delivery 1990;6(4):319-28.
1990: H Okabe; Y Obata; Kozo Takayama; Tsuneji Nagai
Percutaneous absorption enhancing effect and skin irritation of monocyclic monoterpenes.
Drug design and delivery 1990;6(3):229-38.
1990: Kozo Takayama; M Hirata; Yoshiharu Machida; T Masada; T Sannan; Tsuneji Nagai
Effect of interpolymer complex formation on bioadhesive property and drug release phenomenon of compressed tablet consisting of chitosan and sodium hyaluronate.
Chemical & pharmaceutical bulletin 1990;38(7):1993-7.
1990: D Y Quan; R I Higuchi; Kozo Takayama; Kimio Higashiyama; Tsuneji Nagai
Enhancing effect of piperidone derivatives on the percutaneous absorption of indomethacin.
Drug design and delivery 1990;6(1):61-71.
1989: D Quan; R I Higuchi; Kozo Takayama; Kimio Higashiyama; Tsuneji Nagai
Promoting effect of 2-n-alkylcyclohexanones on the percutaneous absorption of indomethacin.
Drug design and delivery 1989;5(2):149-57.
1989: Q Danyi; Kozo Takayama; Tsuneji Nagai
Effect of cyclohexanone derivatives on in vitro percutaneous absorption of indomethacin.
Drug design and delivery 1989;4(4):323-30.
1989: H Okabe; Kozo Takayama; A Ogura; Tsuneji Nagai
Effect of limonene and related compounds on the percutaneous absorption of indomethacin.
Drug design and delivery 1989;4(4):313-21.
1988: J Príborský; Kozo Takayama; Tsuneji Nagai; D Waitzová; J Elis; Y Makino; Y Suzuki
Comparison of penetration-enhancing ability of laurocapram, N-methyl-2-pyrrolidone and dodecyl-L-pyroglutamate.
Pharmaceutisch weekblad. Scientific edition 1988;10(5):189-92.
1988: Y Akasaka; Haruhisa Ueda; Kozo Takayama; Yoshiharu Machida; Tsuneji Nagai
Preparation and evaluation of bovine serum albumin nanospheres coated with monoclonal antibodies.
Drug design and delivery 1988;3(1):85-97.
1988: Y Akitoshi; Kozo Takayama; Yoshiharu Machida; Tsuneji Nagai
Effect of cyclohexanone derivatives on percutaneous absorption of ketoprofen and indomethacin.
Drug design and delivery 1988;2(3):239-45.
1987: Y Nakagawa; Kozo Takayama; Haruhisa Ueda; Yoshiharu Machida; Tsuneji Nagai
Preparation of bovine serum albumin nanospheres as drug targeting carriers.
Drug design and delivery 1987;2(2):99-107.
1987: J Príborský; Kozo Takayama; Tsuneji Nagai; D Waitzová; J Elis
Evaluation of in vitro and in situ transdermal absorption of drugs in pig and rat skin.
Chemical & pharmaceutical bulletin 1987;35(12):4915-20.
1987: J Príborský; Kozo Takayama; Tsuneji Nagai; D Waitzová; J Elis
Combination effect of penetration enhancers and propylene glycol on in vitro transdermal absorption of insulin.
Drug design and delivery 1987;2(2):91-7.
1987: K Arai; Kozo Takayama; Y Nambu; N Nambu; Haruhisa Ueda; Yoshiharu Machida; Tsuneji Nagai
Preparation of polylactic acid-polylipoic acid nanospheres as drug targeting carriers.
Drug design and delivery 1987;2(2):109-20.