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Hiroshi Takayanagi

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Anatomy

Chemicals & Drugs

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Physiology

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Rheumatoid Arthritis

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TOP 3
Masahiro Shinohara; Sakae Tanaka; Kohjiro Ueki; Jun Hirose; Mitsuyasu Iwasawa; Yuho Kadono; Takashi Kadowaki; Shigeaki Kato; Hironari Masuda; Yuuichi Nagase; Hiroaki Nakamura; Masaki Nakamura; Takehiko Sasaki; Hiroshi Takayanagi
Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport.
Mikihito Hayashi; Tomoki Nakashima; Hiroshi Takayanagi
[The regulatory mechanisms of bone metabolism by semaphorin].
Kazuo Okamoto; Hiroshi Takayanagi
[Osteoimmunology-overview].

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2012: Masahiro Shinohara; Sakae Tanaka; Kohjiro Ueki; Jun Hirose; Mitsuyasu Iwasawa; Yuho Kadono; Takashi Kadowaki; Shigeaki Kato; Hironari Masuda; Yuuichi Nagase; Hiroaki Nakamura; Masaki Nakamura; Takehiko Sasaki; Hiroshi Takayanagi
Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2012;27(12):2464-75.
2012: Mikihito Hayashi; Tomoki Nakashima; Hiroshi Takayanagi
[The regulatory mechanisms of bone metabolism by semaphorin].
Clinical calcium 2012;22(11):1693-9.
2012: Kazuo Okamoto; Hiroshi Takayanagi
[Osteoimmunology-overview].
Clinical calcium 2012;22(11):1641-9.
2012: Hiroshi Takayanagi
New developments in osteoimmunology.
Nature reviews. Rheumatology 2012;8(11):684-9.
2012: Tomoki Nakashima; Mikihito Hayashi; Hiroshi Takayanagi
New insights into osteoclastogenic signaling mechanisms.
Trends in endocrinology and metabolism: TEM 2012;23(11):582-90.
2012: Miki Hara-Yokoyama; Satoru Harumiya; Noritaka Hashii; Nobumasa Hino; Yoshio Hirabayashi; Yoko Hiruta; Satsuki Itoh; Yoko Kaitsu; Takeshi Kasama; Toshiaki Katada; Nana Kawasaki; Mutsuko Kukimoto-Niino; Tomoko Matsumoto; Chiemi Mishima-Tsumagari; Katarzyna A Podyma-Inoue; Kensaku Sakamoto; Mikako Shirouzu; Kiyoshi Takatsu; Hiroshi Takayanagi; Kazue Terasawa; Naoko Utsunomiya-Tate; Motoaki Wakiyama; Shigeyuki Yokoyama; Masaki Yanagishita
Tetrameric interaction of the ectoenzyme CD38 on the cell surface enables its catalytic and raft-association activities.
Structure (London, England : 1993) 2012;20(9):1585-95.
2012: Mikihito Hayashi; Tatsuhiko Kodama; Atsushi Kumanogoh; Tomoki Nakashima; Masahiko Taniguchi; Hiroshi Takayanagi
Osteoprotection by semaphorin 3A.
Nature 2012;485(7396):69-74.
2012: Tomoki Nakashima; Mikihito Hayash; Hiroshi Takayanagi
[Regulation of bone resorption by osteocytes].
Clinical calcium 2012;22(5):685-96.
2012: Koji Fujita; Toru Fukuda; Hiroshi Itoh; Makiko Iwasaki; Shigeaki Kato; Tatsuhiko Kodama; Chengshan Ma; Takeshi Miyamoto; Takako Negishi-Koga; Hiroki Ochi; Atsushi Okawa; Kenichi Shinomiya; Satoko Sunamura; Hiroshi Takayanagi; Kimitaka Takitani; Hiroshi Tamai; Hiroyuki Arai; Shu Takeda
Vitamin E decreases bone mass by stimulating osteoclast fusion.
Nature medicine 2012;18(4):589-94.
2012: Kaori Tsuji-Takechi; Shigeaki Kato; Akiko Kukita; Takahiro Maeda; Keiji Moriyama; Takako Negishi-Koga; Pier Paolo Pandolfi; Eriko Sumiya; Hiroshi Takayanagi
Stage-specific functions of leukemia/lymphoma-related factor (LRF) in the transcriptional control of osteoclast development.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(7):2561-6.
2012: Noriko Komatsu; Hiroshi Takayanagi
[Bone and cartilage destruction in rheumatoid arthritis].
Clinical calcium 2012;22(2):179-85.
2012: Noriko Komatsu; Hiroshi Takayanagi
Autoimmune arthritis: the interface between the immune system and joints.
Advances in immunology 2012;115():45-71.
2012: Noriko Komatsu; Hiroshi Takayanagi
Inflammation and bone destruction in arthritis: synergistic activity of immune and mesenchymal cells in joints.
Frontiers in immunology 2012;3():77.
2011: Tomoki Nakashima; Hiroshi Takayanagi
New regulation mechanisms of osteoclast differentiation.
Annals of the New York Academy of Sciences 2011;1240():E13-8.
2011: Tomoki Nakashima; Masatsugu Oh-hora; Josef M Penninger; Lynda F Bonewald; Jian Q Feng; Takanobu Fukunaga; Mikihito Hayashi; Tatsuhiko Kodama; Kosaku Kurata; Erwin F Wagner; Anton Wutz; Hiroshi Takayanagi
Evidence for osteocyte regulation of bone homeostasis through RANKL expression.
Nature medicine 2011;17(10):1231-4.
2011: Shoko Kuroda; Kenji Sakimura; Hiroshi Takayanagi; Maya Yamazaki; Manabu Abe; Yoshiko Iwai
Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression.
Proceedings of the National Academy of Sciences of the United States of America 2011;108(36):14885-9.
2011: Erik Idrus; Tatsuhiko Kodama; Tomoki Nakashima; Kazuo Okamoto; Nobuyuki Tanaka; Tadatsugu Taniguchi; Ling Wang; Mikihito Hayashi; Hiroshi Takayanagi
The role of the BH3-only protein Noxa in bone homeostasis.
Biochemical and biophysical research communications 2011;410(3):620-5.
2011: Noriko Komatsu; Hiroshi Takayanagi
[Animal models for bone and joint disease. Osteoimmunology and animal models for rheumatoid arthritis].
Clinical calcium 2011;21(2):269-76.
2011: Takako Negishi-Koga; Masahiro Shinohara; Haruhiko Bito; Roland H Friedel; Tatsuhiko Kodama; Noriko Komatsu; Hiroshi Takayanagi
Suppression of bone formation by osteoclastic expression of semaphorin 4D.
Nature medicine 2011;17(11):1473-80.
2011: Kazuo Okamoto; Hiroshi Takayanagi
Regulation of bone by the adaptive immune system in arthritis.
Arthritis research & therapy 2011;13(3):219.
2010: Kazuo Okamoto; Yoshiko Iwai; Masatsugu Oh-hora; Masahiro Yamamoto; Tomohiro Morio; Kazuhiro Aoki; Keiichi Ohya; Anton M Jetten; Shizuo Akira; Tatsushi Muta; Hiroshi Takayanagi
IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors.
Nature 2010;464(7293):1381-5.
2010: Mikihito Hayashi; Tomoki Nakashima; Tatsuhiko Kodama; Andrew P Makrigiannis; Noriko Toyama-Sorimachi; Hiroshi Takayanagi
Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation.
Biochemical and biophysical research communications 2010;393(3):432-8.
2010: Hiroshi Takayanagi
New immune connections in osteoclast formation.
Annals of the New York Academy of Sciences 2010;1192():117-23.
2010: Keizo Nishikawa; Tomoki Nakashima; Mikihito Hayashi; Takanobu Fukunaga; Shigeaki Kato; Tatsuhiko Kodama; Satoru Takahashi; Kathryn Calame; Hiroshi Takayanagi
Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(7):3117-22.
2010: Kou Kayamori; Kei Sakamoto; Tomoki Nakashima; Hiroshi Takayanagi; Kei-Ichi Morita; Ken Omura; Su Tien Nguyen; Yoshio Miki; Tadahiro Iimura; Akiko Himeno; Takumi Akashi; Hisafumi Yamada-Okabe; Etsuro Ogata; Akira Yamaguchi
Roles of interleukin-6 and parathyroid hormone-related peptide in osteoclast formation associated with oral cancers: significance of interleukin-6 synthesized by stromal cells in response to cancer cells.
The American journal of pathology 2010;176(2):968-80.
2010: Hiroshi Takayanagi
The unexpected link between osteoclasts and the immune system.
Advances in experimental medicine and biology 2010;658():61-8.
2009: Hiroshi Takayanagi
Osteoimmunology and the effects of the immune system on bone.
Nature reviews. Rheumatology 2009;5(12):667-76.
2009: Yuu Taguchi; Jin Gohda; Takako Koga; Hiroshi Takayanagi; Jun-Ichiro Inoue
A unique domain in RANK is required for Gab2 and PLCgamma2 binding to establish osteoclastogenic signals.
Genes to cells : devoted to molecular & cellular mechanisms 2009;14(11):1331-45.
2009: Takako Negishi-Koga; Hiroshi Takayanagi
Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiation.
Immunological reviews 2009;231(1):241-56.
2009: Tomoki Nakashima; Hiroshi Takayanagi
Osteoimmunology: crosstalk between the immune and bone systems.
Journal of clinical immunology 2009;29(5):555-67.
2009: Hiroshi Takayanagi
[Osteoimmunology update--from bench to bedside].
Nihon rinsho. Japanese journal of clinical medicine 2009;67(5):1031-7.
2009: Hirotaka Inoue; Hiroshi Takayanagi
[Molecular mechanism of bone destruction].
Clinical calcium 2009;19(3):339-46.
2009: Yuho Kadono; Sakae Tanaka; Jinju Nishino; Keita Nishimura; Ichiro Nakamura; Tsuyoshi Miyazaki; Hiroshi Takayanagi; Kozo Nakamura
Rheumatoid arthritis associated with osteopetrosis.
Modern rheumatology / the Japan Rheumatism Association 2009;19(6):687-90.
2009: Tomoki Nakashima; Hiroshi Takayanagi
Osteoclasts and the immune system.
Journal of bone and mineral metabolism 2009;27(5):519-29.
2008: Taishin Akiyama; Yusuke Shimo; Hiromi Yanai; Junwen Qin; Daisuke Ohshima; Yuya Maruyama; Yukiko Asaumi; Juli Kitazawa; Hiroshi Takayanagi; Josef M Penninger; Mitsuru Matsumoto; Takeshi Nitta; Yousuke Takahama; Jun-Ichiro Inoue
The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.
Immunity 2008;29(3):423-37.
2008: Tomoki Nakashima; Hiroshi Takayanagi
The dynamic interplay between osteoclasts and the immune system.
Archives of biochemistry and biophysics 2008;473(2):166-71.
2008: Masahiro Shinohara; Takako Koga; Kazuo Okamoto; Shinya Sakaguchi; Kimiko Arai; Hisataka Yasuda; Toshiyuki Takai; Tatsuhiko Kodama; Tomohiro Morio; Raif S Geha; Daisuke Kitamura; Tomohiro Kurosaki; Wilfried Ellmeier; Hiroshi Takayanagi
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
Cell 2008;132(5):794-806.
2008: Masataka Asagiri; Toshitake Hirai; Toshihiro Kunigami; Shunya Kamano; Hans-Jürgen Gober; Kazuo Okamoto; Keizo Nishikawa; Eicke Latz; Douglas T Golenbock; Kazuhiro Aoki; Keiichi Ohya; Yuuki Imai; Yasuyuki Morishita; Kohei Miyazono; Shigeaki Kato; Paul Saftig; Hiroshi Takayanagi
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
Science (New York, N.Y.) 2008;319(5863):624-7.
2007: Hiroshi Takayanagi
The role of NFAT in osteoclast formation.
Annals of the New York Academy of Sciences 2007;1116():227-37.
2007: Sae Ochi; Masahiro Shinohara; kojiro sato; Hans-Jürgen Gober; Takako Koga; Tatsuhiko Kodama; Toshiyuki Takai; Nobuyuki Miyasaka; Hiroshi Takayanagi
Pathological role of osteoclast costimulation in arthritis-induced bone loss.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(27):11394-9.
2007: Masahiro Shinohara; Hiroshi Takayanagi
Novel osteoclast signaling mechanisms.
Current osteoporosis reports 2007;5(2):67-72.
2007: Hiroshi Takayanagi
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.
Nature reviews. Immunology 2007;7(4):292-304.
2007: Ayako Suematsu; Hiroshi Takayanagi
[Interplay between the immune and skeletal cells in the regulation of inflammatory bone destruction].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2007;30(1):22-8.
2007: Masataka Asagiri; Hiroshi Takayanagi
The molecular understanding of osteoclast differentiation.
Bone 2007;40(2):251-64.
2007: Hiroshi Takayanagi
Novel signaling pathways and therapeutic targets in osteoclasts.
Advances in experimental medicine and biology 2007;602():93-6.
2007: Ayako Suematsu; Yasuhito Tajiri; Tomoki Nakashima; Junko Taka; Sae Ochi; Hiromi Oda; Kozo Nakamura; Sakae Tanaka; Hiroshi Takayanagi
Scientific basis for the efficacy of combined use of antirheumatic drugs against bone destruction in rheumatoid arthritis.
Modern rheumatology / the Japan Rheumatism Association 2007;17(1):17-23.
2006: kojiro sato; Ayako Suematsu; Tomoki Nakashima; Sayaka Takemoto-Kimura; Kazuhiro Aoki; Yasuyuki Morishita; Hiroshi Asahara; Keiichi Ohya; Akira Yamaguchi; Toshiyuki Takai; Tatsuhiko Kodama; Talal A Chatila; Haruhiko Bito; Hiroshi Takayanagi
Regulation of osteoclast differentiation and function by the CaMK-CREB pathway.
Nature medicine 2006;12(12):1410-6.
2006: kojiro sato; Ayako Suematsu; Kazuo Okamoto; Akira Yamaguchi; Yasuyuki Morishita; Yuho Kadono; Sakae Tanaka; Tatsuhiko Kodama; Shizuo Akira; Yoichiro Iwakura; Daniel J Cua; Hiroshi Takayanagi
Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction.
The Journal of experimental medicine 2006;203(12):2673-82.
2006: Hideo Negishi; Yasuyuki Fujita; Hideyuki Yanai; Shinya Sakaguchi; Xinshou Ouyang; Masahiro Shinohara; Hiroshi Takayanagi; Yusuke Ohba; Tadatsugu Taniguchi; Kenya Honda
Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program.
Proceedings of the National Academy of Sciences of the United States of America 2006;103(41):15136-41.
2006: kojiro sato; Hiroshi Takayanagi
Osteoclasts, rheumatoid arthritis, and osteoimmunology.
Current opinion in rheumatology 2006;18(4):419-26.
2005: Hiroshi Takayanagi; kojiro sato; Akinori Takaoka; Tadatsugu Taniguchi
Interplay between interferon and other cytokine systems in bone metabolism.
Immunological reviews 2005;208():181-93.
2005: Masataka Asagiri; kojiro sato; Takako Usami; Sae Ochi; Hiroshi Nishina; Hiroki Yoshida; Ikuo Morita; Erwin F Wagner; Tak W Mak; Edgar Serfling; Hiroshi Takayanagi
Autoamplification of NFATc1 expression determines its essential role in bone homeostasis.
The Journal of experimental medicine 2005;202(9):1261-9.
2005: Yoonji Kim; kojiro sato; Masataka Asagiri; Ikuo Morita; Kunimichi Soma; Hiroshi Takayanagi
Contribution of nuclear factor of activated T cells c1 to the transcriptional control of immunoreceptor osteoclast-associated receptor but not triggering receptor expressed by myeloid cells-2 during osteoclastogenesis.
The Journal of biological chemistry 2005;280(38):32905-13.
2005: kojiro sato; Hiroshi Takayanagi
[Regulation of osteoclastogenesis by activated T cells].
Nihon rinsho. Japanese journal of clinical medicine 2005;63(9):1529-32.
2005: Hiroshi Takayanagi
[Introduction to osteoimmunology].
Nihon rinsho. Japanese journal of clinical medicine 2005;63(9):1505-9.
2005: Hiroshi Takayanagi
[RANKL/RANK signal transduction].
Nihon rinsho. Japanese journal of clinical medicine 2005;63(9):1502-4.
2005: Takako Koga; Yuichi Matsui; Masataka Asagiri; Tatsuhiko Kodama; Benoit de Crombrugghe; Kazuhisa Nakashima; Hiroshi Takayanagi
NFAT and Osterix cooperatively regulate bone formation.
Nature medicine 2005;11(8):880-5.
2005: Hiroshi Takayanagi
Inflammatory bone destruction and osteoimmunology.
Journal of periodontal research 2005;40(4):287-93.
2005: Hiroshi Takayanagi
[GeneChip analysis for osteoimmunology].
Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology 2005;28(2):79-85.
2005: Hiroshi Takatsuna; Masataka Asagiri; Takeshi Kubota; Kotaro Oka; Toshihiro Osada; Chie Sugiyama; Hiroaki Saito; Kazuhiro Aoki; Keiichi Ohya; Hiroshi Takayanagi; Kazuo Umezawa
Inhibition of RANKL-induced osteoclastogenesis by (-)-DHMEQ, a novel NF-kappaB inhibitor, through downregulation of NFATc1.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2005;20(4):653-62.
2005: Jin Gohda; Toru Akiyama; Takako Koga; Hiroshi Takayanagi; Sakae Tanaka; Jun-Ichiro Inoue
RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis.
The EMBO journal 2005;24(4):790-9.
2005: Hiroshi Takayanagi
Osteoimmunological insight into bone damage in rheumatoid arthritis.
Modern rheumatology / the Japan Rheumatism Association 2005;15(4):225-31.
2004: Takako Koga; Masanori Inui; Kazuya Inoue; Sunhwa Kim; Ayako Suematsu; Eiji Kobayashi; Toshio Iwata; Hiroshi Ohnishi; Takashi Matozaki; Tatsuhiko Kodama; Tadatsugu Taniguchi; Hiroshi Takayanagi; Toshiyuki Takai
Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis.
Nature 2004;428(6984):758-63.
2004: Makoto Urushibara; Hiroshi Takayanagi; Takako Koga; Sunhwa Kim; Miho Isobe; Yasuyuki Morishita; Takumi Nakagawa; Monika Löeffler; Tatsuhiko Kodama; Hisashi Kurosawa; Tadatsugu Taniguchi
The antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor activator of NF-kappa B ligand-stimulated induction of nuclear factor of activated T cells c1.
Arthritis and rheumatism 2004;50(3):794-804.
2003: Sunhwa Kim; Takako Koga; Miho Isobe; Britt E Kern; Taeko Yokochi; Y Eugene Chin; Gerard Karsenty; Tadatsugu Taniguchi; Hiroshi Takayanagi
Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation.
Genes & development 2003;17(16):1979-91.
2003: Hiroshi Takayanagi
[Mechanism of bone destruction in rheumatoid arthritis].
Clinical calcium 2003;13(6):694-701.
2002: Hiroshi Takayanagi
[Cross-talk between immune and skeletal systems].
Nihon rinsho. Japanese journal of clinical medicine 2002;60(12):2287-95.
2002: Hiroshi Takayanagi; Sunhwa Kim; Takako Koga; Hiroshi Nishina; Masashi Isshiki; Hiroki Yoshida; Akio Saiura; Miho Isobe; Taeko Yokochi; Jun-Ichiro Inoue; Erwin F Wagner; Tak W Mak; Tatsuhiko Kodama; Tadatsugu Taniguchi
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts.
Developmental cell 2002;3(6):889-901.
2002: Ichiro Nakamura; Yuho Kadono; Hiroshi Takayanagi; Eijiro Jimi; Tsuyoshi Miyazaki; Hiromi Oda; Kozo Nakamura; Sakae Tanaka; Gideon A Rodan; Le T Duong
IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex.
Journal of immunology (Baltimore, Md. : 1950) 2002;168(10):5103-9.
2002: Hiroshi Takayanagi; Sunhwa Kim; Koichi Matsuo; Hiroshi Suzuki; Tomohiko Suzuki; kojiro sato; Taeko Yokochi; Hiromi Oda; Kozo Nakamura; Nobutaka Ida; Erwin F Wagner; Tadatsugu Taniguchi
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta.
Nature 2002;416(6882):744-9.
2002: Aiichiro Yamamoto; Tsuyoshi Miyazaki; Yuho Kadono; Hiroshi Takayanagi; Toshiki Miura; Hiroshi Nishina; Toshiaki Katada; Kenji Wakabayashi; Hiromi Oda; Kozo Nakamura; Sakae Tanaka
Possible involvement of IkappaB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor kappaB ligand.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2002;17(4):612-21.
2002: Kouetsu Ogasawara; Shigeaki Hida; Youmin Weng; Akio Saiura; kojiro sato; Hiroshi Takayanagi; Shinya Sakaguchi; Taeko Yokochi; Tatsuhiko Kodama; Makoto Naitoh; Julie A De Martino; Tadatsugu Taniguchi
Requirement of the IFN-alpha/beta-induced CXCR3 chemokine signalling for CD8+ T cell activation.
Genes to cells : devoted to molecular & cellular mechanisms 2002;7(3):309-20.
2002: Hiroshi Takayanagi; Sunhwa Kim; Tadatsugu Taniguchi
Signaling crosstalk between RANKL and interferons in osteoclast differentiation.
Arthritis research 2002;4 Suppl 3():S227-32.
2001: K Sato; S Hida; Hiroshi Takayanagi; Taeko Yokochi; Nobuhiko Kayagaki; K Takeda; Hideo Yagita; Ko Okumura; Naomi Tanaka; Tadatsugu Taniguchi; Kouetsu Ogasawara
Antiviral response by natural killer cells through TRAIL gene induction by IFN-alpha/beta.
European journal of immunology 2001;31(11):3138-46.
2000: Hiroshi Takayanagi; Kouetsu Ogasawara; Shigeaki Hida; T Chiba; S Murata; kojiro sato; Akinori Takaoka; Taeko Yokochi; Hiromi Oda; Kiyoji Tanaka; Kozo Nakamura; Tadatsugu Taniguchi
T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma.
Nature 2000;408(6812):600-5.
2000: Shigeaki Hida; Kouetsu Ogasawara; kojiro sato; M Abe; Hiroshi Takayanagi; Taeko Yokochi; Toshiro Sato; S Hirose; T Shirai; Shinsuke Taki; Tadatsugu Taniguchi
CD8(+) T cell-mediated skin disease in mice lacking IRF-2, the transcriptional attenuator of interferon-alpha/beta signaling.
Immunity 2000;13(5):643-55.
2000: Hiroshi Takayanagi; H Iizuka; Takeo Juji; Takumi Nakagawa; Aiichiro Yamamoto; Tsuyoshi Miyazaki; Y Koshihara; Hiromi Oda; Kozo Nakamura; Sakae Tanaka
Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis.
Arthritis and rheumatism 2000;43(2):259-69.
2000: Tsuyoshi Miyazaki; H Katagiri; Yumi Kanegae; Hiroshi Takayanagi; Y Sawada; Aiichiro Yamamoto; Matthew Pando; Tomoichiro Asano; Inder M Verma; Hiromi Oda; Kozo Nakamura; Sakae Tanaka
Reciprocal role of ERK and NF-kappaB pathways in survival and activation of osteoclasts.
The Journal of cell biology 2000;148(2):333-42.
2000: Tsuyoshi Miyazaki; Hiroshi Takayanagi; Masashi Isshiki; T Takahashi; M Okada; Y Fukui; Hiromi Oda; Kozo Nakamura; H Hirai; T Kurokawa; Sakae Tanaka
In vitro and in vivo suppression of osteoclast function by adenovirus vector-induced csk gene.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000;15(1):41-51.
1999: Hiroshi Takayanagi; Takeo Juji; Tsuyoshi Miyazaki; H Iizuka; T Takahashi; Masashi Isshiki; M Okada; Yoshiya Tanaka; Y Koshihara; Hiromi Oda; T Kurokawa; Kozo Nakamura; Sakae Tanaka
Suppression of arthritic bone destruction by adenovirus-mediated csk gene transfer to synoviocytes and osteoclasts.
The Journal of clinical investigation 1999;104(2):137-46.
1998: Sakae Tanaka; T Takahashi; Hiroshi Takayanagi; Tsuyoshi Miyazaki; Hiromi Oda; Kozo Nakamura; H Hirai; T Kurokawa
Modulation of osteoclast function by adenovirus vector-induced epidermal growth factor receptor.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998;13(11):1714-20.
1998: T Yoshida; T Horiuchi; H Sakamoto; H Inoue; Hiroshi Takayanagi; Takako Nishikawa; Shigeru Yamamoto; Y Koshihara
Production of parathyroid hormone-related peptide by synovial fibroblasts in human osteoarthritis.
FEBS letters 1998;433(3):331-4.
1997: Hiroshi Takayanagi; Hiromi Oda; Shigeru Yamamoto; Hiroshi Kawaguchi; Sakae Tanaka; Takako Nishikawa; Y Koshihara
A new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesis.
Biochemical and biophysical research communications 1997;240(2):279-86.