FIND

researchers

DISCOVER

relevant articles

PROMOTE

your research

now for free

Toshihiro Takeda

Research Profile

Chemicals & Drugs

Living Beings

Anatomy

Disorders

Physiology

Co-author Network

Publications

TOP 3
Takahito Tamai; Manabu Taneike; Yoshihiro Uno; Osamu Yamaguchi; Jota Oyabu; Ajay M Shah; Nahum Sonenberg; Junji Takeda; Toshihiro Takeda; Shungo Hikoso; Kyoji Horie; Issei Komuro; Tomokazu Murakawa; Hiroyuki Nakayama; Kazuhiko Nishida; Takafumi Oka; Kinya Otsu
Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.
Takafumi Oka; Shizuo Akira; Shungo Hikoso; Issei Komuro; Tomokazu Murakawa; Hiroyuki Nakayama; Kazuhiko Nishida; Jota Oyabu; Toshihiro Takeda; Takahito Tamai; Manabu Taneike; Osamu Yamaguchi; Akitsugu Yamamoto; Kinya Otsu
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.
Yasushi Matsumura; Shigeki Kuwata; Shiro Manabe; Hirokazu Saito; Toshihiro Takeda; Kei Teramoto; Naoki Mihara
Proposal of diagnostic process model for computer based diagnosis.

Register for free to view:

Visualized networks:

See your personal network in
sophisticated graphical views

GeoTargeted Searches:

Locate experts around the world
and connect with global collaborators

Research Profiles:

See the research activity
of experts around the globe

Geonetwork of Toshihiro Takeda (preview)

Cities where this author has publications
Cities where co-authors of this author have publications

Flash Player Required

All Publications

2013: Takahito Tamai; Manabu Taneike; Yoshihiro Uno; Osamu Yamaguchi; Jota Oyabu; Ajay M Shah; Nahum Sonenberg; Junji Takeda; Toshihiro Takeda; Shungo Hikoso; Kyoji Horie; Issei Komuro; Tomokazu Murakawa; Hiroyuki Nakayama; Kazuhiko Nishida; Takafumi Oka; Kinya Otsu
Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period.
The Journal of biological chemistry 2013;288(14):10176-87.
2012: Takafumi Oka; Shizuo Akira; Shungo Hikoso; Issei Komuro; Tomokazu Murakawa; Hiroyuki Nakayama; Kazuhiko Nishida; Jota Oyabu; Toshihiro Takeda; Takahito Tamai; Manabu Taneike; Osamu Yamaguchi; Akitsugu Yamamoto; Kinya Otsu
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure.
Nature 2012;485(7397):251-5.
2012: Yasushi Matsumura; Shigeki Kuwata; Shiro Manabe; Hirokazu Saito; Toshihiro Takeda; Kei Teramoto; Naoki Mihara
Proposal of diagnostic process model for computer based diagnosis.
Studies in health technology and informatics 2012;180():315-9.
2010: Manabu Taneike; Osamu Yamaguchi; Jota Oyabu; Takahiko Shimizu; Toshihiro Takeda; Takuji Shirasawa Takuji Shirasawa; Takahito Tamai; Shungo Hikoso; Masatsugu Hori; Issei Komuro; Isamu Mizote; Noboru Mizushima; Tomokazu Murakawa; Atsuko Nakai; Kazuhiko Nishida; Takafumi Oka; Kinya Otsu
Inhibition of autophagy in the heart induces age-related cardiomyopathy.
Autophagy 2010;6(5):600-6.
2010: Isamu Mizote; Osamu Yamaguchi; Shungo Hikoso; Toshihiro Takeda; Manabu Taneike; Takafumi Oka; Takahito Tamai; Jota Oyabu; Yasushi Matsumura; Kazuhiko Nishida; Issei Komuro; Masatsugu Hori; Kinya Otsu
Activation of MTK1/MEKK4 induces cardiomyocyte death and heart failure.
Journal of molecular and cellular cardiology 2010;48(2):302-9.
2009: Shungo Hikoso; Osamu Yamaguchi; Yuko Nakano; Toshihiro Takeda; Shigemiki Omiya; Isamu Mizote; Manabu Taneike; Takafumi Oka; Takahito Tamai; Jota Oyabu; Yoshihiro Uno; Yasushi Matsumura; Kazuhiko Nishida; Keiichiro Suzuki; Mikihiko Kogo; Masatsugu Hori; Kinya Otsu
The I{kappa}B kinase {beta}/nuclear factor {kappa}B signaling pathway protects the heart from hemodynamic stress mediated by the regulation of manganese superoxide dismutase expression.
Circulation research 2009;105(1):70-9.
2008: Tetsuya Watanabe; Toshihiro Takeda; Shigemiki Omiya; Shungo Hikoso; Osamu Yamaguchi; Yuko Nakano; Yoshiharu Higuchi; Atsuko Nakai; Yusuke Abe; Yayoi Aki-Jin; Masako Taniike; Isamu Mizote; Yasushi Matsumura; Takahiko Shimizu; Kazuhiko Nishida; Kiyohiro Imai; Masatsugu Hori; Takuji Shirasawa; Kinya Otsu
Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure.
Journal of the American College of Cardiology 2008;52(9):779-86.
2008: Masako Taniike; Osamu Yamaguchi; Ikuko Tsujimoto; Shungo Hikoso; Toshihiro Takeda; Atsuko Nakai; Shigemiki Omiya; Isamu Mizote; Yuko Nakano; Yoshiharu Higuchi; Yasushi Matsumura; Kazuhiko Nishida; Hidenori Ichijo; Masatsugu Hori; Kinya Otsu
Apoptosis signal-regulating kinase 1/p38 signaling pathway negatively regulates physiological hypertrophy.
Circulation 2008;117(4):545-52.
2007: Shungo Hikoso; Ikeda Yasuhiro; Osamu Yamaguchi; Toshihiro Takeda; Yoshiharu Higuchi; Shinichi Hirotani; Kazunori Kashiwase; Michio Yamada; Michio Asahi; Yasushi Matsumura; Kazuhiko Nishida; Masunori Matsuzaki; Masatsugu Hori; Kinya Otsu
Progression of heart failure was suppressed by inhibition of apoptosis signal-regulating kinase 1 via transcoronary gene transfer.
Journal of the American College of Cardiology 2007;50(5):453-62.
2007: Atsuko Nakai; Osamu Yamaguchi; Toshihiro Takeda; Yoshiharu Higuchi; Shungo Hikoso; Masako Taniike; Shigemiki Omiya; Isamu Mizote; Yasushi Matsumura; Michio Asahi; Kazuhiko Nishida; Masatsugu Hori; Noboru Mizushima; Kinya Otsu
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress.
Nature medicine 2007;13(5):619-24.
2005: Toshihiro Takeda; Michio Asahi; Osamu Yamaguchi; Shungo Hikoso; Hiroyuki Nakayama; Yoichiro Kusakari; Makoto Kawai; Kenichi Hongo; Yoshiharu Higuchi; Kazunori Kashiwase; Tetsuya Watanabe; Masako Taniike; Atsuko Nakai; Kazuhiko Nishida; Satoshi Kurihara; Dorit B Donoviel; alan bernstein; Taisuke Tomita; Takeshi Iwatsubo; Masatsugu Hori; Kinya Otsu
Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2005;19(14):2069-71.
2005: Toshihiro Takeda; Kinya Otsu; Masatsugu Hori
[Calcium channel blocker and cardiac hypertrophy].
Clinical calcium 2005;15(10):1645-9.
2005: Tetsuya Watanabe; Kinya Otsu; Toshihiro Takeda; Osamu Yamaguchi; Shungo Hikoso; Kazunori Kashiwase; Yoshiharu Higuchi; Masako Taniike; Atsuko Nakai; Yasushi Matsumura; Kazuhiko Nishida; Hidenori Ichijo; Masatsugu Hori
Apoptosis signal-regulating kinase 1 is involved not only in apoptosis but also in non-apoptotic cardiomyocyte death.
Biochemical and biophysical research communications 2005;333(2):562-7.
2005: Ikuko Tsujimoto; Shungo Hikoso; Osamu Yamaguchi; Kazunori Kashiwase; Atsuko Nakai; Toshihiro Takeda; Tetsuya Watanabe; Masako Taniike; Yasushi Matsumura; Kazuhiko Nishida; Masatsugu Hori; Mikihiko Kogo; Kinya Otsu
The antioxidant edaravone attenuates pressure overload-induced left ventricular hypertrophy.
Hypertension 2005;45(5):921-6.
2005: Kazunori Kashiwase; Yoshiharu Higuchi; Shinichi Hirotani; Osamu Yamaguchi; Shungo Hikoso; Toshihiro Takeda; Tetsuya Watanabe; Masako Taniike; Atsuko Nakai; Ikuko Tsujimoto; Yasushi Matsumura; Hikaru Ueno; Kazuhiko Nishida; Masatsugu Hori; Kinya Otsu
CaMKII activates ASK1 and NF-kappaB to induce cardiomyocyte hypertrophy.
Biochemical and biophysical research communications 2005;327(1):136-42.
2004: Kazuhiko Nishida; Osamu Yamaguchi; Shinichi Hirotani; Shungo Hikoso; Yoshiharu Higuchi; Tetsuya Watanabe; Toshihiro Takeda; Osuka Soh; Takashi Morita; Gen Kondoh; Yoshihiro Uno; Kazunori Kashiwase; Masako Taniike; Atsuko Nakai; Yasushi Matsumura; Jun-ichi Miyazaki; Tatsuhiko Sudo; Kenichi Hongo; Yoichiro Kusakari; Satoshi Kurihara; Kenneth R Chien; Junji Takeda; Masatsugu Hori; Kinya Otsu
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload.
Molecular and cellular biology 2004;24(24):10611-20.
2004: Shungo Hikoso; Osamu Yamaguchi; Yoshiharu Higuchi; Shinichi Hirotani; Toshihiro Takeda; Kazunori Kashiwase; Tetsuya Watanabe; Masako Taniike; Ikuko Tsujimoto; Michio Asahi; Yasushi Matsumura; Kazuhiko Nishida; Hiroshi Nakajima; Shizuo Akira; Masatsugu Hori; Kinya Otsu
Pressure overload induces cardiac dysfunction and dilation in signal transducer and activator of transcription 6-deficient mice.
Circulation 2004;110(17):2631-7.
2004: Osamu Yamaguchi; Tetsuya Watanabe; Kazuhiko Nishida; Kazunori Kashiwase; Yoshiharu Higuchi; Toshihiro Takeda; Shungo Hikoso; Shinichi Hirotani; Michio Asahi; Masako Taniike; Atsuko Nakai; Ikuko Tsujimoto; Yasushi Matsumura; Jun-ichi Miyazaki; Kenneth R Chien; Atsushi Matsuzawa; Chiharu Sadamitsu; Hidenori Ichijo; Manuela Baccarini; Masatsugu Hori; Kinya Otsu
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis.
The Journal of clinical investigation 2004;114(7):937-43.
2004: Michio Asahi; Kinya Otsu; Hiroyuki Nakayama; Shungo Hikoso; Toshihiro Takeda; Anthony O Gramolini; Maria G Trivieri; Gavin Y Oudit; Takashi Morita; Yoichiro Kusakari; Shuta Hirano; Kenichi Hongo; Shinichi Hirotani; Osamu Yamaguchi; Alan Peterson; Peter H Backx; Satoshi Kurihara; Masatsugu Hori; David H MacLennan
Cardiac-specific overexpression of sarcolipin inhibits sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA2a) activity and impairs cardiac function in mice.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(25):9199-204.
2004: Shinichi Hirotani; Yoshiharu Higuchi; Kazuhiko Nishida; Hiroyuki Nakayama; Osamu Yamaguchi; Shungo Hikoso; Toshihiro Takeda; Kazunori Kashiwase; Tetsuya Watanabe; Michio Asahi; Masako Taniike; Ikuko Tsujimoto; Yasushi Matsumura; Terukatsu Sasaki; Masatsugu Hori; Kinya Otsu
Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy.
Journal of molecular and cellular cardiology 2004;36(6):799-807.
2003: Osamu Yamaguchi; Yoshiharu Higuchi; Shinichi Hirotani; Kazunori Kashiwase; Hiroyuki Nakayama; Shungo Hikoso; Toshihiro Takeda; Tetsuya Watanabe; Michio Asahi; Masako Taniike; Yasushi Matsumura; Ikuko Tsujimoto; Kenichi Hongo; Yoichiro Kusakari; Satoshi Kurihara; Kazuhiko Nishida; Hidenori Ichijo; Masatsugu Hori; Kinya Otsu
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling.
Proceedings of the National Academy of Sciences of the United States of America 2003;100(26):15883-8.
2003: Yoshiharu Higuchi; Kinya Otsu; Kazuhiko Nishida; Shinichi Hirotani; Hiroyuki Nakayama; Osamu Yamaguchi; Shungo Hikoso; Kazunori Kashiwase; Toshihiro Takeda; Tetsuya Watanabe; Toshiaki Mano; Yasushi Matsumura; Hikaru Ueno; Masatsugu Hori
The small GTP-binding protein Rac1 induces cardiac myocyte hypertrophy through the activation of apoptosis signal-regulating kinase 1 and nuclear factor-kappa B.
The Journal of biological chemistry 2003;278(23):20770-7.
2003: Hiroyuki Nakayama; Kinya Otsu; Osamu Yamaguchi; Kazuhiko Nishida; Moto-o Date; Kenichi Hongo; Yoichiro Kusakari; Toshihiko Toyofuku; Shungo Hikoso; Kazunori Kashiwase; Toshihiro Takeda; Yasushi Matsumura; Satoshi Kurihara; Masatsugu Hori; Michihiko Tada
Cardiac-specific overexpression of a high Ca2+ affinity mutant of SERCA2a attenuates in vivo pressure overload cardiac hypertrophy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003;17(1):61-3.
2000: H Homma; Hirohisa Kurachi; Yukihiro Nishio; Toshihiro Takeda; T Yamamoto; Kazushige Adachi; Ken-ichirou Morishige; Masahide Ohmichi; Yuji Matsuzawa; Yuji Murata
Estrogen suppresses transcription of lipoprotein lipase gene. Existence of a unique estrogen response element on the lipoprotein lipase promoter.
The Journal of biological chemistry 2000;275(15):11404-11.
1998: Kunihiro Matsumoto; T Yamamoto; Hirohisa Kurachi; Yukihiro Nishio; Toshihiro Takeda; H Homma; Ken-ichirou Morishige; A Miyake; Yuji Murata
Human chorionic gonadotropin-alpha gene is transcriptionally activated by epidermal growth factor through cAMP response element in trophoblast cells.
The Journal of biological chemistry 1998;273(14):7800-6.