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Genzou Takemura

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Yoshihisa Yamada; Takuma Aoyama; Hisayoshi Fujiwara; Takako Fujiwara; Masamitsu Iwasa; Makoto Kiso; Hiroyuki Kobayashi; Kazuhiko Nishigaki; Shohei Sumi; Genzou Takemura; Hiroaki Ushikoshi; Shinya Minatoguchi
Postinfarct active cardiac-targeted delivery of erythropoietin by liposomes with sialyl Lewis X repairs infarcted myocardium in rabbits.
Hiromitsu Kanamori; Tomonori Kawaguchi; Masanori Kawasaki; Atsushi Mikami; Kentaro Morishita; Atsushi Ogino; Mitsuru Seishima; Genzou Takemura; Toshiaki Takeyama; Akiko Tsujimoto; Takatomo Watanabe; Hisayoshi Fujiwara; Takako Fujiwara; Kazuko Goto; Shinya Minatoguchi
Resveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway.
Tomonori Kawaguchi; Masanori Kawasaki; Rumi Maruyama; Atsushi Mikami; Hisayoshi Fujiwara; Takako Fujiwara; Kazuko Goto; Hiromitsu Kanamori; Kentaro Morishita; Atsushi Ogino; Genzou Takemura; Toshiaki Takeyama; Akiko Tsujimoto; Takatomo Watanabe; Shinya Minatoguchi
Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes.

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All Publications

2013: Yoshihisa Yamada; Takuma Aoyama; Hisayoshi Fujiwara; Takako Fujiwara; Masamitsu Iwasa; Makoto Kiso; Hiroyuki Kobayashi; Kazuhiko Nishigaki; Shohei Sumi; Genzou Takemura; Hiroaki Ushikoshi; Shinya Minatoguchi
Postinfarct active cardiac-targeted delivery of erythropoietin by liposomes with sialyl Lewis X repairs infarcted myocardium in rabbits.
American journal of physiology. Heart and circulatory physiology 2013;304(8):H1124-33.
2013: Hiromitsu Kanamori; Tomonori Kawaguchi; Masanori Kawasaki; Atsushi Mikami; Kentaro Morishita; Atsushi Ogino; Mitsuru Seishima; Genzou Takemura; Toshiaki Takeyama; Akiko Tsujimoto; Takatomo Watanabe; Hisayoshi Fujiwara; Takako Fujiwara; Kazuko Goto; Shinya Minatoguchi
Resveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway.
The American journal of pathology 2013;182(3):701-13.
2012: Tomonori Kawaguchi; Masanori Kawasaki; Rumi Maruyama; Atsushi Mikami; Hisayoshi Fujiwara; Takako Fujiwara; Kazuko Goto; Hiromitsu Kanamori; Kentaro Morishita; Atsushi Ogino; Genzou Takemura; Toshiaki Takeyama; Akiko Tsujimoto; Takatomo Watanabe; Shinya Minatoguchi
Prior starvation mitigates acute doxorubicin cardiotoxicity through restoration of autophagy in affected cardiomyocytes.
Cardiovascular research 2012;96(3):456-65.
2012: Tomonori Kawaguchi; Masanori Kawasaki; Tomoki Kubota; Shinya Minatoguchi; Kazuhiko Nishigaki; Mieko Takasugi; Nobuhiro Takasugi; Genzou Takemura; Hiroaki Ushikoshi; Takuma Aoyama; Arihiro Hattori; Hiromitsu Kanamori; Richard L Verrier
In-hospital monitoring of T-wave alternans in a case of amiodarone-induced torsade de pointes: clinical and methodologic insights.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2012;14(9):1372-4.
2012: Nobuhiro Takasugi; Genzou Takemura; Hiroaki Ushikoshi; Kazuhiko Nishigaki; Mieko Takasugi; Takuma Aoyama; Arihiro Hattori; Hiromitsu Kanamori; Itta Kawamura; Masanori Kawasaki; Tomoki Kubota; Shinya Minatoguchi
Sudden reversible pacemaker failure in a patient with cardiac sarcoidosis: an unfortunate case of ventricular septal pacing.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2012;14(7):1061-2.
2012: Takashi Nakashima; Kazuhiko Nishigaki; Mieko Takasugi; Nobuhiro Takasugi; Genzou Takemura; Hiroaki Ushikoshi; Takuma Aoyama; Arihiro Hattori; Hiromitsu Kanamori; Masanori Kawasaki; Tomoki Kubota; Shinya Minatoguchi
'False-positive' intrathoracic impedance monitor alarm caused by amiodarone-induced hypothyroidism in a patient with cardiac resynchronization therapy-defibrillator.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2012;14(5):768-9.
2012: Toshiaki Takeyama; Akiko Tsujimoto; Hiroaki Ushikoshi; Takatomo Watanabe; Kazunari Yamada; Kentaro Morishita; Hideki Nikami; Atsushi Ogino; Genzou Takemura; Hisayoshi Fujiwara; Takako Fujiwara; Kazuko Goto; Hiromitsu Kanamori; Tomonori Kawaguchi; Masanori Kawasaki; Rumi Maruyama; Shinya Minatoguchi
Asialoerythropoietin, a nonerythropoietic derivative of erythropoietin, displays broad anti-heart failure activity.
Circulation. Heart failure 2012;5(2):274-85.
2012: Tai Kojima; Takeshi Hirose; Makoto Iwama; Masanori Kawasaki; Toshiyuki Noda; Koji Ono; Genzou Takemura; Ryuhei Tanaka; Sachiro Watanabe; Takatomo Watanabe; Shinya Minatoguchi
Left atrial global and regional function in patients with paroxysmal atrial fibrillation has already been impaired before enlargement of left atrium: velocity vector imaging echocardiography study.
European heart journal cardiovascular Imaging 2012;13(3):227-34.
2012: Takeshi Hirose; Makoto Iwama; Masanori Kawasaki; Toshiyuki Noda; Koji Ono; Genzou Takemura; Ryuhei Tanaka; Sachiro Watanabe; Takatomo Watanabe; Shinya Minatoguchi
Left atrial function assessed by speckle tracking echocardiography as a predictor of new-onset non-valvular atrial fibrillation: results from a prospective study in 580 adults.
European heart journal cardiovascular Imaging 2012;13(3):243-50.
2012: Koji Ono; Genzou Takemura; Ryuhei Tanaka; Shunichiro Warita; Sachiro Watanabe; Takatomo Watanabe; Masazumi Arai; Yoshiaki Goto; Makoto Iwama; Takashi Kato; Masanori Kawasaki; Tai Kojima; Kazuhiko Nishigaki; Toshiyuki Noda; Noriyuki Onishi; Shinya Minatoguchi
Motion of left atrial appendage as a determinant of thrombus formation in patients with a low CHADS2 score receiving warfarin for persistent nonvalvular atrial fibrillation.
Cardiovascular ultrasound 2012;10():50.
2012: Shunichiro Warita; Sachiro Watanabe; Takatomo Watanabe; Takeshi Hirose; Makoto Iwama; Masanori Kawasaki; Tai Kojima; Kazuhiko Nishigaki; Toshiyuki Noda; Koji Ono; Genzou Takemura; Ryuhei Tanaka; Shinya Minatoguchi
Effects of pitavastatin on cardiac structure and function and on prevention of atrial fibrillation in elderly hypertensive patients: a prospective study of 2-years' follow-up.
Circulation journal : official journal of the Japanese Circulation Society 2012;76(12):2755-62.
2012: Takahiko Yamaki; Hisayoshi Fujiwara; Arihiro Hattori; Yoshiyuki Ishihara; Ik-Kyung Jang; Masanori Kawasaki; Tomoki Kubota; Kazuhiko Nishigaki; Munenori Okubo; Owen Christopher Raffel; Genzou Takemura; Shinya Minatoguchi
Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques.
Cardiovascular ultrasound 2012;10():33.
2012: Yoshiyuki Ishihara; Masanori Kawasaki; Tomoki Kubota; Kazuhiko Nishigaki; Shinsuke Ojio; Munenori Okubo; Hironobu Sato; Shigekiyo Takahashi; Genzou Takemura; Hisayoshi Fujiwara; Arihiro Hattori; Hajime Imai; Shinya Minatoguchi
Relationship among coronary plaque compliance, coronary risk factors and tissue characteristics evaluated by integrated backscatter intravascular ultrasound.
Cardiovascular ultrasound 2012;10():32.
2012: Tomoki Kubota; Hajime Imai; Yoshiyuki Ishihara; Masanori Kawasaki; Kazuhiko Nishigaki; Munenori Okubo; Hironobu Sato; Shigekiyo Takahashi; Nobuhiro Takasugi; Genzou Takemura; Shinya Minatoguchi
Left atrial pathological degeneration assessed by integrated backscatter transesophageal echocardiography as a predictor of progression to persistent atrial fibrillation: results from a prospective study of three-years follow-up.
Cardiovascular ultrasound 2012;10():28.
2012: Bulin Baila; Junki Endo; Hisayoshi Fujiwara; Takako Fujiwara; Norihiko Funaguchi; Fumitaka Ito; Kounori Kotosai; Hidenori Mori; Hisashi Nagamoto; Yasushi Ohno; Genzou Takemura; Youichi Yabuuchi; Shinya Minatoguchi
Tetomilast attenuates elastase-induced pulmonary emphysema through inhibition of oxidative stress in rabbits.
Biological & pharmaceutical bulletin 2012;35(4):494-502.
2011: Tsuneaki Kawashima; Takeshi Kimura; Toru Kita; Tetsuya Matsuda; Michiko Narazaki; Shinichiro Niizuma; Junji Okuda; Souichi Adachi; Yasutaka Inuzuka; Yoshitaka Iwanaga; Takao Kato; Akira Kawamoto; Genzou Takemura; Yodo Tamaki; Tetsuo Shioi
Constitutive SIRT1 overexpression impairs mitochondria and reduces cardiac function in mice.
Journal of molecular and cellular cardiology 2011;51(6):1026-36.
2011: Masaaki Yoshida; Haruo Honjo; Itsuo Kodama; Yoichi Mizukami; Tadamitsu Nakashima; Tomoko Ohkusa; Hiroki Takanari; Genzou Takemura; Masafumi Yano; Masunori Matsuzaki
Alterations in adhesion junction precede gap junction remodelling during the development of heart failure in cardiomyopathic hamsters.
Cardiovascular research 2011;92(1):95-105.
2011: Yushan Bai; Masamitsu Iwasa; Takuma Aoyama; Hiroya Murakami; Kazuhiko Nishigaki; Shohei Sumi; Genzou Takemura; Bunji Uno; Hiroaki Ushikoshi; Yoshihisa Yamada; Shinya Minatoguchi
Cilostazol protects the heart against ischaemia reperfusion injury in a rabbit model of myocardial infarction: focus on adenosine, nitric oxide and mitochondrial ATP-sensitive potassium channels.
Clinical and experimental pharmacology & physiology 2011;38(10):658-65.
2011: Nobuhiro Takasugi; Genzou Takemura; Hiroaki Ushikoshi; Richard L Verrier; Takuma Aoyama; Arihiro Hattori; Masanori Kawasaki; Tomoki Kubota; Kazuhiko Nishigaki; Shinsuke Ojio; Mieko Takasugi; Shinya Minatoguchi
Relationship between T-wave alternans magnitude and T-wave amplitude before the onset of ventricular tachyarrhythmias during emergent reperfusion in acute coronary syndrome patients.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2011;13(10):1511-2; author reply 1512; discussion 1512-3.
2011: Masamitsu Iwasa; Itta Kawamura; Hiroyuki Kobayashi; Takuma Aoyama; Hisayoshi Fujiwara; Arihiro Hattori; Kazuhiko Nishigaki; Takeru Shiraki; Shohei Sumi; Genzou Takemura; Hiroaki Ushikoshi; Yoshihisa Yamada; Takahiko Yamaki; Shinji Yasuda; Shinya Minatoguchi
Both stimulation of GLP-1 receptors and inhibition of glycogenolysis additively contribute to a protective effect of oral miglitol against ischaemia-reperfusion injury in rabbits.
British journal of pharmacology 2011;164(1):119-31.
2011: Hiromitsu Kanamori; Tomonori Kawaguchi; Rumi Maruyama; Atsushi Ogino; Mitsuru Seishima; Genzou Takemura; Toshiaki Takeyama; Akiko Tsujimoto; Takatomo Watanabe; Hisayoshi Fujiwara; Takako Fujiwara; Kazuko Goto; Shinya Minatoguchi
The role of autophagy emerging in postinfarction cardiac remodelling.
Cardiovascular research 2011;91(2):330-9.
2011: Hiromitsu Kanamori; Genzou Takemura; Kazuko Goto; Rumi Maruyama; Koh Ono; Kazuya Nagao; Akiko Tsujimoto; Atsushi Ogino; Toshiaki Takeyama; Tomonori Kawaguchi; Takatomo Watanabe; Masanori Kawasaki; Takako Fujiwara; Hisayoshi Fujiwara; Mitsuru Seishima; Shinya Minatoguchi
Autophagy limits acute myocardial infarction induced by permanent coronary artery occlusion.
American journal of physiology. Heart and circulatory physiology 2011;300(6):H2261-71.
2011: Nobuhiro Takasugi; Tomoki Kubota; Kazuhiko Nishigaki; Richard L Verrier; Masanori Kawasaki; Mieko Takasugi; Hiroaki Ushikoshi; Arihiro Hattori; Shinsuke Ojio; Takuma Aoyama; Genzou Takemura; Shinya Minatoguchi
Continuous T-wave alternans monitoring to predict impending life-threatening cardiac arrhythmias during emergent coronary reperfusion therapy in patients with acute coronary syndrome.
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2011;13(5):708-15.
2011: Itta Kawamura; Genzou Takemura; Akiko Tsujimoto; Takatomo Watanabe; Hiromitsu Kanamori; Masayasu Esaki; Hiroyuki Kobayashi; Toshiaki Takeyama; Tomonori Kawaguchi; Kazuko Goto; Rumi Maruyama; T Fujiwara; Hisayoshi Fujiwara; Yasuhiko Tabata; Shinya Minatoguchi
Treatment of leg ischemia with biodegradable gelatin hydrogel microspheres incorporating granulocyte colony-stimulating factor.
Journal of cardiovascular pharmacology 2011;57(4):416-23.
2011: Kenji Onoue; Nobuhiro Zaima; Yuki Sugiura; Takuya Isojima; Satoshi Okayama; Manabu Horii; Yasuhiro Akai; Shiro Uemura; Genzou Takemura; Hitoshi Sakuraba; Yasuhiro Sakaguchi; Mitsutoshi Setou; Yoshihiko Saito
Using imaging mass spectrometry to accurately diagnose Fabry's disease.
Circulation journal : official journal of the Japanese Circulation Society 2011;75(1):221-3.
2010: Atsushi Ogino; Genzou Takemura; Masanori Kawasaki; Akiko Tsujimoto; Hiromitsu Kanamori; Longhu Li; Kazuko Goto; Rumi Maruyama; Itta Kawamura; Toshiaki Takeyama; Tomonori Kawaguchi; Takatomo Watanabe; Yoshiyuki Moriguchi; Hideki Saito; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
Erythropoietin receptor signaling mitigates renal dysfunction-associated heart failure by mechanisms unrelated to relief of anemia.
Journal of the American College of Cardiology 2010;56(23):1949-58.
2010: Masanori Kawasaki; Arihiro Hattori; Yoshiyuki Ishihara; Munenori Okubo; Kazuhiko Nishigaki; Genzou Takemura; Masanao Saio; Tsuyoshi Takami; Shinya Minatoguchi
Tissue characterization of coronary plaques and assessment of thickness of fibrous cap using integrated backscatter intravascular ultrasound. Comparison with histology and optical coherence tomography.
Circulation journal : official journal of the Japanese Circulation Society 2010;74(12):2641-8.
2010: Shohei Sumi; Hiroyuki Kobayashi; Shinji Yasuda; Masamitsu Iwasa; Takahiko Yamaki; Yoshihisa Yamada; Hiroaki Ushikoshi; Arihiro Hattori; Takuma Aoyama; Kazuhiko Nishigaki; Genzou Takemura; Shinya Minatoguchi
Postconditioning effect of granulocyte colony-stimulating factor is mediated through activation of risk pathway and opening of the mitochondrial KATP channels.
American journal of physiology. Heart and circulatory physiology 2010;299(4):H1174-82.
2010: Itta Kawamura; Genzou Takemura; Hiromitsu Kanamori; Toshiaki Takeyama; Tomonori Kawaguchi; Akiko Tsujimoto; Kazuko Goto; Rumi Maruyama; Takatomo Watanabe; Takeru Shiraki; Takuma Aoyama; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
Repeated phlebotomy augments angiogenesis to improve blood flow in murine ischemic legs.
American journal of physiology. Heart and circulatory physiology 2010;299(2):H372-8.
2010: Genzou Takemura
Does the tongue eloquently address the question of cardiac regeneration?
Circulation journal : official journal of the Japanese Circulation Society 2010;74(6):1075-6.
2010: Masamitsu Iwasa; Hiroyuki Kobayashi; Shinji Yasuda; Itta Kawamura; Shohei Sumi; Yoshihisa Yamada; Takeru Shiraki; Takahiko Yamaki; Hiroaki Ushikoshi; Takuma Aoyama; Kazuhiko Nishigaki; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
Antidiabetic drug voglibose is protective against ischemia-reperfusion injury through glucagon-like peptide 1 receptors and the phosphoinositide 3-kinase-Akt-endothelial nitric oxide synthase pathway in rabbits.
Journal of cardiovascular pharmacology 2010;55(6):625-34.
2010: Hitoo Nishi; Koh Ono; Yoshitaka Iwanaga; Takahiro Horie; Kazuya Nagao; Genzou Takemura; Minako Kinoshita; Yasuhide Kuwabara; Rieko Takanabe Mori; Koji Hasegawa; Toru Kita; Takeshi Kimura
MicroRNA-15b modulates cellular ATP levels and degenerates mitochondria via Arl2 in neonatal rat cardiac myocytes.
The Journal of biological chemistry 2010;285(7):4920-30.
2010: Shusaku Miyata; Genzou Takemura; Ken-ichiro Kosai; Tomoyuki Takahashi; Masayasu Esaki; Longhu Li; Hiromitsu Kanamori; Rumi Maruyama; Kazuko Goto; Akiko Tsujimoto; Toshiaki Takeyama; Tomonori Kawaguchi; Takamasa Ohno; Kazuhiko Nishigaki; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
Anti-Fas gene therapy prevents doxorubicin-induced acute cardiotoxicity through mechanisms independent of apoptosis.
The American journal of pathology 2010;176(2):687-98.
2010: Masayuki Shimomura; Hiroaki Ushikoshi; Arihiro Hattori; Ichijiro Murata; Yasushi Ohno; Takuma Aoyama; Masanori Kawasaki; Kazuhiko Nishigaki; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
Treatment with Lindera strychnifolia reduces blood pressure by decreasing sympathetic nerve activity in spontaneously hypertensive rats.
The American journal of Chinese medicine 2010;38(3):561-8.
2009: Hiroyuki Kobayashi; Shinji Yasuda; Narentuoya Bao; Masamitsu Iwasa; Itta Kawamura; Yoshihisa Yamada; Takahiko Yamaki; Syohei Sumi; Hiroaki Ushikoshi; Kazuhiko Nishigaki; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
Postinfarct treatment with oxytocin improves cardiac function and remodeling via activating cell-survival signals and angiogenesis.
Journal of cardiovascular pharmacology 2009;54(6):510-9.
2009: Nobuhiro Takasugi; Kazuhiko Nishigaki; Tomoki Kubota; Kunihiko Tsuchiya; Kenji Natsuyama; Mieko Takasugi; Takahide Nawa; Shinsuke Ojio; Takuma Aoyama; Masanori Kawasaki; Genzou Takemura; Shinya Minatoguchi
Sleep apnoea induces cardiac electrical instability assessed by T-wave alternans in patients with congestive heart failure.
European journal of heart failure 2009;11(11):1063-70.
2009: Yasuaki Nakagawa; Koichiro Kuwahara; Genzou Takemura; Masaharu Akao; Masashi Kato; Yuji Arai; Makoto Takano; Masaki Harada; Masao Murakami; Michio Nakanishi; Satoru Usami; Shinji Yasuno; Hideyuki Kinoshita; Masataka Fujiwara; Kenji Ueshima; Kazuwa Nakao
p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal hearts.
Circulation research 2009;105(8):746-54.
2009: Genzou Takemura
[Pathophysiological significance of apoptosis and its potential for treating heart diseases].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2009;134(4):192-7.
2009: Longhu Li; Hideshi Okada; Genzou Takemura; Ken-ichiro Kosai; Hiromitsu Kanamori; Masayasu Esaki; Tomoyuki Takahashi; Kazuko Goto; Akiko Tsujimoto; Rumi Maruyama; Itta Kawamura; Tomonori Kawaguchi; Toshiaki Takeyama; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
Postinfarction gene therapy with adenoviral vector expressing decorin mitigates cardiac remodeling and dysfunction.
American journal of physiology. Heart and circulatory physiology 2009;297(4):H1504-13.
2009: Genzou Takemura; Hiromitsu Kanamori; Kazuko Goto; Rumi Maruyama; Akiko Tsujimoto; Hisayoshi Fujiwara; Mitsuru Seishima; Shinya Minatoguchi
Autophagy maintains cardiac function in the starved adult.
Autophagy 2009;5(7):1034-6.
2009: Tomoki Kubota; Masanori Kawasaki; Nobuhiro Takasugi; Urara Takeyama; Yoshiyuki Ishihara; Munenori Okubo; Takahiko Yamaki; Shinsuke Ojio; Takuma Aoyama; Masazumi Arai; Kazuhiko Nishigaki; Genzou Takemura; Hisayoshi Fujiwara; Shinya Minatoguchi
Evaluation of left atrial degeneration for the prediction of atrial fibrillation: usefulness of integrated backscatter transesophageal echocardiography.
JACC. Cardiovascular imaging 2009;2(9):1039-47.
2009: Genzou Takemura; Munehiro Nakagawa; Hiromitsu Kanamori; Shinya Minatoguchi; Hisayoshi Fujiwara
Benefits of reperfusion beyond infarct size limitation.
Cardiovascular research 2009;83(2):269-76.
2009: Shinya Minatoguchi; Zengi Zhang; Narentuoya Bao; Hiroyuki Kobayashi; Shinji Yasuda; Masamitsu Iwasa; Syouhei Sumi; Itta Kawamura; Yoshihisa Yamada; Kazuhiko Nishigaki; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara
Acarbose reduces myocardial infarct size by preventing postprandial hyperglycemia and hydroxyl radical production and opening mitochondrial KATP channels in rabbits.
Journal of cardiovascular pharmacology 2009;54(1):25-30.
2009: Longhu Li; Hideshi Okada; Genzou Takemura; Masayasu Esaki; Hiroyuki Kobayashi; Hiromitsu Kanamori; Itta Kawamura; Rumi Maruyama; Takako Fujiwara; Hisayoshi Fujiwara; Yasuhiko Tabata; Shinya Minatoguchi
Sustained release of erythropoietin using biodegradable gelatin hydrogel microspheres persistently improves lower leg ischemia.
Journal of the American College of Cardiology 2009;53(25):2378-88.
2009: Kazuko Goto; Genzou Takemura; Rumi Maruyama; Munehiro Nakagawa; Akiko Tsujimoto; Hiromitsu Kanamori; Longhu Li; Itta Kawamura; Tomonori Kawaguchi; Toshiaki Takeyama; Hisayoshi Fujiwara; Shinya Minatoguchi
Unique mode of cell death in freshly isolated adult rat ventricular cardiomyocytes exposed to hydrogen peroxide.
Medical molecular morphology 2009;42(2):92-101.
2009: Hiromitsu Kanamori; Genzou Takemura; Rumi Maruyama; Kazuko Goto; Akiko Tsujimoto; Atsushi Ogino; Longhu Li; Itta Kawamura; Toshiaki Takeyama; Tomonori Kawaguchi; Kenshi Nagashima; Takako Fujiwara; Hisayoshi Fujiwara; Mitsuru Seishima; Shinya Minatoguchi
Functional significance and morphological characterization of starvation-induced autophagy in the adult heart.
The American journal of pathology 2009;174(5):1705-14.
2009: Shinji Yasuda; Hiroyuki Kobayashi; Masamitsu Iwasa; Itta Kawamura; Shouhei Sumi; Bao Narentuoya; Takahiko Yamaki; Hiroaki Ushikoshi; Kazuhiko Nishigaki; Kenshi Nagashima; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction.
American journal of physiology. Heart and circulatory physiology 2009;296(5):H1558-65.
2009: Hideshi Okada; Genzou Takemura; Ken-Ichiro Kosai; Akiko Tsujimoto; Masayasu Esaki; Tomoyuki Takahashi; Satoshi Nagano; Hiromitsu Kanamori; Shusaku Miyata; Yiwen Li; Takamasa Ohno; Rumi Maruyama; Atsushi Ogino; Longhu Li; Munehiro Nakagawa; Kenshi Nagashima; Takako Fujiwara; Hisayoshi Fujiwara; Shinya Minatoguchi
Combined therapy with cardioprotective cytokine administration and antiapoptotic gene transfer in postinfarction heart failure.
American journal of physiology. Heart and circulatory physiology 2009;296(3):H616-26.
2009: Narentuoya Bao; Hiroaki Ushikoshi; Hiroyuki Kobayashi; Shinji Yasuda; Itta Kawamura; Masamitsu Iwasa; Takahiko Yamaki; Shohei Sumi; Kenshi Nagashima; Takuma Aoyama; Masanori Kawasaki; Kazuhiko Nishigaki; Genzou Takemura; Shinya Minatoguchi
Simvastatin reduces myocardial infarct size via increased nitric oxide production in normocholesterolemic rabbits.
Journal of cardiology 2009;53(1):102-7.
2009: Koji Ono; Masanori Kawasaki; Ryuhei Tanaka; Tomonori Segawa; Hitoshi Matsuo; Sachiro Watanabe; Genzou Takemura; Shinya Minatoguchi
Integrated backscatter and intima-media thickness of the thoracic aorta evaluated by transesophageal echocardiography in hypercholesterolemic patients: effect of pitavastatin therapy.
Ultrasound in medicine & biology 2009;35(2):193-200.
2008: Takehito Kondo; Genzou Takemura; Ken-ichiro Kosai; Takamasa Ohno; Tomoyuki Takahashi; Masayasu Esaki; Kazuko Goto; Rumi Maruyama; Ichijiro Murata; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Application of an adenoviral vector encoding soluble transforming growth factor-beta type II receptor to the treatment of diabetic nephropathy in mice.
Clinical and experimental pharmacology & physiology 2008;35(11):1288-93.
2008: Munenori Okubo; Masanori Kawasaki; Yoshiyuki Ishihara; Urara Takeyama; Shinji Yasuda; Tomoki Kubota; Shinichiro Tanaka; Takahiko Yamaki; Shinsuke Ojio; Kazuhiko Nishigaki; Genzou Takemura; Masanao Saio; Tsuyoshi Takami; Hisayoshi Fujiwara; Shinya Minatoguchi
Tissue characterization of coronary plaques: comparison of integrated backscatter intravascular ultrasound with virtual histology intravascular ultrasound.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(10):1631-9.
2008: Rumi Maruyama; Kazuko Goto; Genzou Takemura; Koh Ono; Kazuya Nagao; Takahiro Horie; Akiko Tsujimoto; Hiromitsu Kanamori; Shusaku Miyata; Hiroaki Ushikoshi; Kenshi Nagashima; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Morphological and biochemical characterization of basal and starvation-induced autophagy in isolated adult rat cardiomyocytes.
American journal of physiology. Heart and circulatory physiology 2008;295(4):H1599-607.
2008: Hiroyuki Kobayashi; Shinya Minatoguchi; Shinji Yasuda; Narentuoya Bao; Itta Kawamura; Masamitsu Iwasa; Takahiko Yamaki; Syohei Sumi; Yu Misao; Hiroaki Ushikoshi; Kazuhiko Nishigaki; Genzou Takemura; Takako Fujiwara; Yasuhiko Tabata; Hisayoshi Fujiwara
Post-infarct treatment with an erythropoietin-gelatin hydrogel drug delivery system for cardiac repair.
Cardiovascular research 2008;79(4):611-20.
2008: Shinichiro Tanaka; Kazuhiko Nishigaki; Shinsuke Ojio; Munenori Okubo; Shinji Yasuda; Yoshiyuki Ishihara; Tomoki Kubota; Nobuhiro Takasugi; Itta Kawamura; Takahiko Yamaki; Hiroaki Ushikoshi; Takuma Aoyama; Masanori Kawasaki; Genzou Takemura; Shinya Minatoguchi
Can negative cardiac effect of proton pump inhibitor and high-dose H2-blocker have clinical influence on patients with stable angina?
Journal of cardiology 2008;52(1):39-48.
2008: Hideshi Okada; Genzou Takemura; Yiwen Li; Takamasa Ohno; Longhu Li; Rumi Maruyama; Masayasu Esaki; Shusaku Miyata; Hiromitsu Kanamori; Atsushi Ogino; Munehiro Nakagawa; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Effect of a long-term treatment with a low-dose granulocyte colony-stimulating factor on post-infarction process in the heart.
Journal of cellular and molecular medicine 2008;12(4):1272-83.
2008: Munehiro Nakagawa; Genzou Takemura; Hiromitsu Kanamori; Kazuko Goto; Rumi Maruyama; Akiko Tsujimoto; Takamasa Ohno; Hideshi Okada; Atsushi Ogino; Masayasu Esaki; Shusaku Miyata; Longhu Li; Hiroaki Ushikoshi; Takuma Aoyama; Masanori Kawasaki; Kenshi Nagashima; Takako Fujiwara; Shinya Minatoguchi; Hisayoshi Fujiwara
Mechanisms by which late coronary reperfusion mitigates postinfarction cardiac remodeling.
Circulation research 2008;103(1):98-106.
2008: Shinichiro Tanaka; Chiharu Yokoyama; Itta Kawamura; Nobuhiro Takasugi; Tomoki Kubota; Hiroaki Ushikoshi; Takuma Aoyama; Masanori Kawasaki; Kazuhiko Nishigaki; Genzou Takemura; Shinya Minatoguchi
Conservative medication follow-up for over 20 years of a patient with ischemic heart disease after diagnosis of chronic total occlusion of the 3 main coronary arteries.
Circulation journal : official journal of the Japanese Circulation Society 2008;72(7):1205-9.
2008: Munenori Okubo; Masanori Kawasaki; Yoshiyuki Ishihara; Urara Takeyama; Tomoki Kubota; Takahiko Yamaki; Shinsuke Ojio; Kazuhiko Nishigaki; Genzou Takemura; Masanao Saio; Tsuyoshi Takami; Shinya Minatoguchi; Hisayoshi Fujiwara
Development of integrated backscatter intravascular ultrasound for tissue characterization of coronary plaques.
Ultrasound in medicine & biology 2008;34(4):655-63.
2008: Masayasu Esaki; Genzou Takemura; Ken-ichiro Kosai; Tomoyuki Takahashi; Shusaku Miyata; Longhu Li; Kazuko Goto; Rumi Maruyama; Hideshi Okada; Hiromitsu Kanamori; Atsushi Ogino; Hiroaki Ushikoshi; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Treatment with an adenoviral vector encoding hepatocyte growth factor mitigates established cardiac dysfunction in doxorubicin-induced cardiomyopathy.
American journal of physiology. Heart and circulatory physiology 2008;294(2):H1048-57.
2007: Xue-Hai Chen; Shinya Minatoguchi; Ken-ichiro Kosai; Kentaro Yuge; Tomoyuki Takahashi; Masazumi Arai; Ningyuan Wang; Yu Misao; Chuanjiang Lu; Hirohito Onogi; Hiroyuki Kobayashi; Shinji Yasuda; Masayasu Ezaki; Hiroaki Ushikoshi; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara
In vivo hepatocyte growth factor gene transfer reduces myocardial ischemia-reperfusion injury through its multiple actions.
Journal of cardiac failure 2007;13(10):874-83.
2007: Narentuoya Bao; Shinya Minatoguchi; Hiroyuki Kobayashi; Shinji Yasuda; Itta Kawamura; Masamitsu Iwasa; Takahiko Yamaki; Syohei Sumi; Yu Misao; Masazumi Arai; Kazuhiko Nishigaki; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara
Pravastatin reduces myocardial infarct size via increasing protein kinase C-dependent nitric oxide, decreasing oxyradicals and opening the mitochondrial adenosine triphosphate-sensitive potassium channels in rabbits.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(10):1622-8.
2007: Atsushi Ogino; Genzou Takemura; Hiromitsu Kanamori; Hideshi Okada; Rumi Maruyama; Shusaku Miyata; Masayasu Esaki; Munehiro Nakagawa; Takuma Aoyama; Hiroaki Ushikoshi; Masanori Kawasaki; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Amlodipine inhibits granulation tissue cell apoptosis through reducing calcineurin activity to attenuate postinfarction cardiac remodeling.
American journal of physiology. Heart and circulatory physiology 2007;293(4):H2271-80.
2007: Munehiro Nakagawa; Takamasa Ohno; Rumi Maruyama; Munenori Okubo; Akito Nagatsu; Makoto Inoue; Hiroki Tanabe; Genzou Takemura; Shinya Minatoguchi; Hisayoshi Fujiwara
Sesquiterpene lactone suppresses vascular smooth muscle cell proliferation and migration via inhibition of cell cycle progression.
Biological & pharmaceutical bulletin 2007;30(9):1754-7.
2007: Masahiro Sawada; Yasushi Ohno; Bu Lin Bai La; Norihiko Funaguchi; Toshihiro Asai; Hideyuki Yuhgetsu; Genzou Takemura; Shinya Minatoguchi; Hisayoshi Fujiwara; Takako Fujiwara
The Fas/Fas-ligand pathway does not mediate the apoptosis in elastase-induced emphysema in mice.
Experimental lung research 2007;33(6):277-88.
2007: Norihiko Funaguchi; Yasushi Ohno; Bu Lin Bai La; Toshihiro Asai; Hideyuki Yuhgetsu; Masahiro Sawada; Genzou Takemura; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Narirutin inhibits airway inflammation in an allergic mouse model.
Clinical and experimental pharmacology & physiology 2007;34(8):766-70.
2007: Longhu Li; Genzou Takemura; Yiwen Li; Shusaku Miyata; Masayasu Esaki; Hideshi Okada; Hiromitsu Kanamori; Atsushi Ogino; Rumi Maruyama; Munehiro Nakagawa; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Granulocyte colony-stimulating factor improves left ventricular function of doxorubicin-induced cardiomyopathy.
Laboratory investigation; a journal of technical methods and pathology 2007;87(5):440-55.
2007: Hiromitsu Kanamori; Genzou Takemura; Yiwen Li; Hideshi Okada; Rumi Maruyama; Takuma Aoyama; Shusaku Miyata; Masayasu Esaki; Atsushi Ogino; Munehiro Nakagawa; Hiroaki Ushikoshi; Masanori Kawasaki; Shinya Minatoguchi; Hisayoshi Fujiwara
Inhibition of Fas-associated apoptosis in granulation tissue cells accompanies attenuation of postinfarction left ventricular remodeling by olmesartan.
American journal of physiology. Heart and circulatory physiology 2007;292(5):H2184-94.
2007: Genzou Takemura
[Apoptosis and autophagy in cardiomyocytes].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 4():143-8.
2007: Hisayoshi Fujiwara; Genzou Takemura
[Recent advances and future issues in basic research of heart failure].
Nihon rinsho. Japanese journal of clinical medicine 2007;65 Suppl 4():9-16.
2007: Katsuaki Miyajima; Shinya Minatoguchi; Yoko Ito; Masanori Hukunishi; Yasunari Matsuno; Masao Kakami; Masanori Kawasaki; Kazuhiko Nishigaki; Genzou Takemura; Hisayoshi Fujiwara
Reduction of QTc dispersion by the angiotensin II receptor blocker valsartan may be related to its anti-oxidative stress effect in patients with essential hypertension.
Hypertension research : official journal of the Japanese Society of Hypertension 2007;30(4):307-13.
2007: Yu Misao; Masazumi Arai; Takamasa Ohno; Hiroaki Ushikoshi; Hirohito Onogi; Hiroyuki Kobayashi; Genzou Takemura; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Modification of post-myocardial infarction granulocyte-colony stimulating factor therapy with myelo-suppressives.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(4):580-90.
2007: Xuehai Chen; Shinya Minatoguchi; Masazumi Arai; Ningyuan Wang; Cuanjiang Lu; Bao Narentuoya; Yoshihiro Uno; Yu Misao; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara
Celiprolol, a selective beta1-blocker, reduces the infarct size through production of nitric oxide in a rabbit model of myocardial infarction.
Circulation journal : official journal of the Japanese Circulation Society 2007;71(4):574-9.
2007: Yiwen Li; Genzou Takemura; Hideshi Okada; Shusaku Miyata; Rumi Maruyama; Masayasu Esaki; Hiromitsu Kanamori; Longhu Li; Atsushi Ogino; Takamasa Ohno; Takehito Kondo; Munehiro Nakagawa; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Molecular signaling mediated by angiotensin II type 1A receptor blockade leading to attenuation of renal dysfunction-associated heart failure.
Journal of cardiac failure 2007;13(2):155-62.
2007: Genzou Takemura; Hisayoshi Fujiwara
Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management.
Progress in cardiovascular diseases 2007;49(5):330-52.
2007: Yiwen Li; Genzou Takemura; Hideshi Okada; Shusaku Miyata; Hiromitsu Kanamori; Rumi Maruyama; Masayasu Esaki; Longhu Li; Atsushi Ogino; Takamasa Ohno; Takehito Kondo; Munehiro Nakagawa; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
ANG II type 1A receptor signaling causes unfavorable scar dynamics in the postinfarct heart.
American journal of physiology. Heart and circulatory physiology 2007;292(2):H946-53.
2007: Kensuke Io; Shinya Minatoguchi; Kazuhiko Nishigaki; Shinsuke Ojio; Tsutomu Tanaka; Tomonori Segawa; Hitoshi Matsuo; Sachiro Watanabe; Arihiro Hattori; Katsumi Ueno; Hiroyoshi Ono; Kunihiko Hiei; Hironobu Sato; Norihiko Morita; Toshiyuki Noda; Toshihiko Kato; Masanori Kawasaki; Genzou Takemura; Hisayoshi Fujiwara
Effects of benidipine and some other calcium channel blockers on the prognosis of patients with vasospastic angina. Cohort study with evaluation of the ergonovine coronary spasm induction test.
Arzneimittel-Forschung 2007;57(9):573-81.
2007: Toshihiro Asai; Yasushi Ohno; Shinya Minatoguchi; Norihiko Funaguchi; Hideyuki Yuhgetsu; Masahiro Sawada; Genzou Takemura; A Komada; Takako Fujiwara; Hisayoshi Fujiwara
The specific free radical scavenger edaravone suppresses bleomycin-induced acute pulmonary injury in rabbits.
Clinical and experimental pharmacology & physiology 2007;34(1-2):22-6.
2006: Chuanjiang Lu; Shinya Minatoguchi; Masazumi Arai; Ningyuan Wang; Xue-Hai Chen; Narentuoya Bao; Itta Kawamura; Shinji Yasuda; Hiroyuki Kobayashi; Der-Jinn Wu; Genzou Takemura; Hisayoshi Fujiwara
Nicorandil improves post-ischemic myocardial dysfunction in association with opening the mitochondrial K(ATP) channels and decreasing hydroxyl radicals in isolated rat hearts.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(12):1650-4.
2006: Hirohito Onogi; Shinya Minatoguchi; Xue-Hai Chen; Narentuoya Bao; Hiroyuki Kobayashi; Yu Misao; Shinji Yasuda; Takahiko Yamaki; Rumi Maruyama; Yoshihiro Uno; Masazumi Arai; Genzou Takemura; Hisayoshi Fujiwara
Edaravone reduces myocardial infarct size and improves cardiac function and remodelling in rabbits.
Clinical and experimental pharmacology & physiology 2006;33(11):1035-41.
2006: Tomoyuki Takahashi; Takao Kawai; Hiroaki Ushikoshi; Satoshi Nagano; Hatsue Oshika; Makoto Inoue; Takahiro Kunisada; Genzou Takemura; Hisayoshi Fujiwara; Ken-ichiro Kosai
Identification and isolation of embryonic stem cell-derived target cells by adenoviral conditional targeting.
Molecular therapy : the journal of the American Society of Gene Therapy 2006;14(5):673-83.
2006: Hideyuki Yuhgetsu; Yasushi Ohno; Norihiko Funaguchi; Toshihiro Asai; Masahiro Sawada; Genzou Takemura; Shinya Minatoguchi; Hisayoshi Fujiwara; Takako Fujiwara
Beneficial effects of autologous bone marrow mononuclear cell transplantation against elastase-induced emphysema in rabbits.
Experimental lung research 2006;32(9):413-26.
2006: Akiko Tsujimoto; Genzou Takemura; Atsushi Mikami; Takuma Aoyama; Takamasa Ohno; Rumi Maruyama; Munehiro Nakagawa; Shinya Minatoguchi; Hisayoshi Fujiwara
A therapeutic dose of the lipophilic statin pitavastatin enhances oxidant-induced apoptosis in human vascular smooth muscle cells.
Journal of cardiovascular pharmacology 2006;48(4):160-5.
2006: Masazumi Arai; Yu Misao; Hiroshi Nagai; Masanori Kawasaki; Kenshi Nagashima; Koji Suzuki; Kunihiko Tsuchiya; Setsuko Otsuka; Yoshihiro Uno; Genzou Takemura; Kazuhiko Nishigaki; Shinya Minatoguchi; Hisayoshi Fujiwara
Granulocyte colony-stimulating factor: a noninvasive regeneration therapy for treating atherosclerotic peripheral artery disease.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(9):1093-8.
2006: Yiwen Li; Genzou Takemura; Hideshi Okada; Shusaku Miyata; Rumi Maruyama; Longhu Li; Masato Higuchi; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Reduction of inflammatory cytokine expression and oxidative damage by erythropoietin in chronic heart failure.
Cardiovascular research 2006;71(4):684-94.
2006: Masanori Fukunishi; Kazuhiko Nishigaki; Munenori Okubo; Masanori Kawasaki; Genzou Takemura; Shinya Minatoguchi; Hisayoshi Fujiwara
J-SAP study 1-2: outcomes of patients with stable high-risk coronary artery disease receiving medical-preceding therapy in Japan.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(8):1012-6.
2006: Yu Misao; Genzou Takemura; Masazumi Arai; Takamasa Ohno; Hirohito Onogi; Tomoyuki Takahashi; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF.
Cardiovascular research 2006;71(3):455-65.
2006: Genzou Takemura; Shusaku Miyata; Yukinori Kawase; Hideshi Okada; Rumi Maruyama; Hisayoshi Fujiwara
Autophagic degeneration and death of cardiomyocytes in heart failure.
Autophagy 2006;2(3):212-4.
2006: Masahiko Koda; Genzou Takemura; Hideshi Okada; Motoo Kanoh; Rumi Maruyama; Masayasu Esaki; Yiwen Li; Shusaku Miyata; Hiromitsu Kanamori; Longhu Li; Atsushi Ogino; Takehito Kondo; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Nuclear hypertrophy reflects increased biosynthetic activities in myocytes of human hypertrophic hearts.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(6):710-8.
2006: Chuanjiang Lu; Masazumi Arai; Yu Misao; Xuehai Chen; Ningyuan Wang; Hirohito Onogi; Hiroyuki Kobayashi; Yoshihiro Uno; Genzou Takemura; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Autologous bone marrow cell transplantation improves left ventricular function in rabbit hearts with cardiomyopathy via myocardial regeneration-unrelated mechanisms.
Heart and vessels 2006;21(3):180-7.
2006: Koji Suzuki; Kenshi Nagashima; Masazumi Arai; Yoshihiro Uno; Yu Misao; Genzou Takemura; Kazuhiko Nishigaki; Shinya Minatoguchi; Sachiro Watanabe; Chuwa Tei; Hisayoshi Fujiwara
Effect of granulocyte colony-stimulating factor treatment at a low dose but for a long duration in patients with coronary heart disease.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(4):430-7.
2006: Shintaro Tanihata; Kazuhiko Nishigaki; Masanori Kawasaki; Genzou Takemura; Shinya Minatoguchi; Hisayoshi Fujiwara
Outcomes of patients with stable low-risk coronary artery disease receiving medical- and PCI-preceding therapies in Japan: J-SAP study 1-1.
Circulation journal : official journal of the Japanese Circulation Society 2006;70(4):365-9.
2006: Rumi Maruyama; Genzou Takemura; Noritsugu Tohse; Tomoko Ohkusa; Yasuhiro Ikeda; Kunihiko Tsuchiya; Shinya Minatoguchi; Masunori Matsuzaki; Takako Fujiwara; Hisayoshi Fujiwara
Synchronous progression of calcium transient-dependent beating and sarcomere destruction in apoptotic adult cardiomyocytes.
American journal of physiology. Heart and circulatory physiology 2006;290(4):H1493-502.
2006: Shusaku Miyata; Genzou Takemura; Yukinori Kawase; Yiwen Li; Hideshi Okada; Rumi Maruyama; Hiroaki Ushikoshi; Masayasu Esaki; Hiromitsu Kanamori; Longhu Li; Yu Misao; Asaki Tezuka; Teruhiko Toyo-Oka; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Autophagic cardiomyocyte death in cardiomyopathic hamsters and its prevention by granulocyte colony-stimulating factor.
The American journal of pathology 2006;168(2):386-97.
2006: Yu Misao; Genzou Takemura; Masazumi Arai; Shigeru Sato; Koji Suzuki; Shusaku Miyata; Ken-ichiro Kosai; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Bone marrow-derived myocyte-like cells and regulation of repair-related cytokines after bone marrow cell transplantation.
Cardiovascular research 2006;69(2):476-90.
2006: Longhu Li; Genzou Takemura; Yiwen Li; Shusaku Miyata; Masayasu Esaki; Hideshi Okada; Hiromitsu Kanamori; Ngin Cin Khai; Rumi Maruyama; Atsushi Ogino; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Preventive effect of erythropoietin on cardiac dysfunction in doxorubicin-induced cardiomyopathy.
Circulation 2006;113(4):535-43.
2006: Genzou Takemura; Hisayoshi Fujiwara
Morphological aspects of apoptosis in heart diseases.
Journal of cellular and molecular medicine 2006;10(1):56-75.
2006: Tomoyo Kagawa; Genzou Takemura; Ken-ichiro Kosai; Ichijiro Murata; Takamasa Ohno; Tomoyuki Takahashi; Masayasu Esaki; Rumi Maruyama; Takako Fujiwara; Hiroshige Ohashi; Hisayoshi Fujiwara
Hepatocyte growth factor gene therapy slows down the progression of diabetic nephropathy in db/db mice.
Nephron. Physiology 2006;102(3-4):p92-102.
2006: Yiwen Li; Genzou Takemura; Hideshi Okada; Shusaku Miyata; Masayasu Esaki; Rumi Maruyama; Hiromitsu Kanamori; Longhu Li; Atsushi Ogino; Yu Misao; Ngin Cin Khai; Atsushi Mikami; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Treatment with granulocyte colony-stimulating factor ameliorates chronic heart failure.
Laboratory investigation; a journal of technical methods and pathology 2006;86(1):32-44.
2005: Yoshihiro Uno; Shinya Minatoguchi; Masazumi Arai; Ningyuan Wang; Xue-Hai Chen; Kazuaki Hashimoto; Cuanjiang Lu; Genzou Takemura; Hisayoshi Fujiwara
The anti-diabetic drug miglitol is protective against anginal ischaemia through a mechanism independent of regional myocardial blood flow in the dog.
Clinical and experimental pharmacology & physiology 2005;32(10):805-10.
2005: Takamasa Ohno; Genzou Takemura; Ichijiro Murata; Tomoyo Kagawa; Seigo Akao; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Water extract of the root of Lindera strychnifolia slows down the progression of diabetic nephropathy in db/db mice.
Life sciences 2005;77(12):1391-403.
2005: Hideshi Okada; Genzou Takemura; Masahiko Koda; Motoo Kanoh; Yukinori Kawase; Shinya Minatoguchi; Hisayoshi Fujiwara
Myocardial apoptotic index based on in situ DNA nick end-labeling of endomyocardial biopsies does not predict prognosis of dilated cardiomyopathy.
Chest 2005;128(2):1060-2.
2005: Hiroaki Ushikoshi; Tomoyuki Takahashi; Xuehai Chen; Ngin Cin Khai; Masayasu Esaki; Kazuko Goto; Genzou Takemura; Rumi Maruyama; Shinya Minatoguchi; Takako Fujiwara; Satoshi Nagano; Kentaro Yuge; Takao Kawai; Yoshiteru Murofushi; Hisayoshi Fujiwara; Ken-ichiro Kosai
Local overexpression of HB-EGF exacerbates remodeling following myocardial infarction by activating noncardiomyocytes.
Laboratory investigation; a journal of technical methods and pathology 2005;85(7):862-73.
2005: Yu Misao; Masazumi Arai; Takamasa Ohno; Hiroaki Ushikoshi; Tomoyuki Takahashi; Genzou Takemura; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Cyclophosphamide improves the function of post-infarct hearts by reducing old infarct area and accelerating the mobilization of CD34+ cells.
Circulation journal : official journal of the Japanese Circulation Society 2005;69(6):763-5.
2005: Hideshi Okada; Genzou Takemura; Ken-ichiro Kosai; Yiwen Li; Tomoyuki Takahashi; Masayasu Esaki; Kentaro Yuge; Shusaku Miyata; Rumi Maruyama; Atsushi Mikami; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Postinfarction gene therapy against transforming growth factor-beta signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure.
Circulation 2005;111(19):2430-7.
2005: Keiji Sano; Masanori Kawasaki; Munenori Okubo; Haruko Yokoyama; Yoko Ito; Ichijiro Murata; Takao Kawai; Kunihiko Tsuchiya; Kazuhiko Nishigaki; Genzou Takemura; Shinya Minatoguchi; Xiangrong Zhou; Hiroshi Fujita; Hisayoshi Fujiwara
In vivo quantitative tissue characterization of angiographically normal coronary lesions and the relation with risk factors: a study using integrated backscatter intravascular ultrasound.
Circulation journal : official journal of the Japanese Circulation Society 2005;69(5):543-9.
2005: Masanori Kawasaki; Yoko Ito; Haruko Yokoyama; Masazumi Arai; Genzou Takemura; Akira Hara; Yoshiro Ichiki; Hisato Takatsu; Shinya Minatoguchi; Hisayoshi Fujiwara
Assessment of arterial medial characteristics in human carotid arteries using integrated backscatter ultrasound and its histological implications.
Atherosclerosis 2005;180(1):145-54.
2005: Hiroshi Nagai; Shinya Minatoguchi; Xue-Hai Chen; Ningyuan Wang; Masazumi Arai; Yoshihiro Uno; Chuanjiang Lu; Yu Misao; Hirohito Onogi; Hiroyuki Kobayashi; Genzou Takemura; Rumi Maruyama; Takako Fujiwara; Hisayoshi Fujiwara
Cilnidipine, an N+L-type dihydropyridine Ca channel blocker, suppresses the occurrence of ischemia/reperfusion arrhythmia in a rabbit model of myocardial infarction.
Hypertension research : official journal of the Japanese Society of Hypertension 2005;28(4):361-8.
2005: Kaori Baba; Shinya Minatoguchi; Chengxi Zhang; Tatsuya Kariya; Yoshihiro Uno; Takao Kawai; Masahiko Takahashi; Genzou Takemura; Hisayoshi Fujiwara
Alpha1-receptor or adenosine A1-receptor dependent pathway alone is not sufficient but summation of these pathways is required to achieve an ischaemic preconditioning effect in rabbits.
Clinical and experimental pharmacology & physiology 2005;32(4):263-8.
2004: Genzou Takemura; Hisayoshi Fujiwara
Role of apoptosis in remodeling after myocardial infarction.
Pharmacology & therapeutics 2004;104(1):1-16.
2004: Yiwen Li; Genzou Takemura; Ken-ichiro Kosai; Tomoyuki Takahashi; Hideshi Okada; Shusaku Miyata; Kentaro Yuge; Satoshi Nagano; Masayasu Esaki; Ngin Cin Khai; Kazuko Goto; Atsushi Mikami; Rumi Maruyama; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Critical roles for the Fas/Fas ligand system in postinfarction ventricular remodeling and heart failure.
Circulation research 2004;95(6):627-36.
2004: Mieko Saijo; Genzou Takemura; Masahiko Koda; Hideshi Okada; Shusaku Miyata; Yasushi Ohno; Masanori Kawasaki; Kunihiko Tsuchiya; Kazuhiko Nishigaki; Shinya Minatoguchi; Koshi Goto; Hisayoshi Fujiwara
Cardiomyopathy with prominent autophagic degeneration, accompanied by an elevated plasma brain natriuretic peptide level despite the lack of overt heart failure.
Internal medicine (Tokyo, Japan) 2004;43(8):700-3.
2004: Yoko Ito; Masanori Kawasaki; Haruko Yokoyama; Munenori Okubo; Keiji Sano; Masazumi Arai; Kazuhiko Nishigaki; Yoshihiro Uno; Genzou Takemura; Shinya Minatoguchi; Hisayoshi Fujiwara
Different effects of pravastatin and cerivastatin on the media of the carotid arteries as assessed by integrated backscatter ultrasound.
Circulation journal : official journal of the Japanese Circulation Society 2004;68(8):784-90.
2004: Ningyuan Wang; Shinya Minatoguchi; Xuehai Chen; Yoshihiro Uno; Masazumi Arai; ChuanJiang Lu; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara
Antidiabetic drug miglitol inhibits myocardial apoptosis involving decreased hydroxyl radical production and Bax expression in an ischaemia/reperfusion rabbit heart.
British journal of pharmacology 2004;142(6):983-90.
2004: Ningyuan Wang; Shinya Minatoguchi; Xue-Hai Chen; Masazumi Arai; Yoshihiro Uno; ChuanJiang Lu; Yu Misao; Hiroshi Nagai; Genzou Takemura; Hisayoshi Fujiwara
Benidipine reduces myocardial infarct size involving reduction of hydroxyl radicals and production of protein kinase C-dependent nitric oxide in rabbits.
Journal of cardiovascular pharmacology 2004;43(6):747-57.
2004: Shinya Minatoguchi; Genzou Takemura; Xue-Hai Chen; Ningyuan Wang; Yoshihiro Uno; Masahiko Koda; Masazumi Arai; Yu Misao; Chuanjiang Lu; Koji Suzuki; Kazuko Goto; Ai Komada; Tomoyuki Takahashi; Ken-ichiro Kosai; Takako Fujiwara; Hisayoshi Fujiwara
Acceleration of the healing process and myocardial regeneration may be important as a mechanism of improvement of cardiac function and remodeling by postinfarction granulocyte colony-stimulating factor treatment.
Circulation 2004;109(21):2572-80.
2004: Kaori Baba; Shinya Minatoguchi; Hirotake Sano; Tomoyo Kagawa; Ichijiro Murata; Genzou Takemura; Takahiro Hirano; Hiroshige Ohashi; Masao Takemura; Takako Fujiwara; Hisayoshi Fujiwara
Involvement of apoptosis in patients with diabetic nephropathy: A study on plasma soluble Fas levels and pathological findings.
Nephrology (Carlton, Vic.) 2004;9(2):94-9.
2004: Ningyuan Wang; Shinya Minatoguchi; Masazumi Arai; Yoshihiro Uno; Kazuaki Hashimoto; Chen Xue-Hai; Kazunori Fukuda; Seigo Akao; Genzou Takemura; Hisayoshi Fujiwara
Lindera strychnifolia is protective against post-ischemic myocardial dysfunction through scavenging hydroxyl radicals and opening the mitochondrial KATP channels in isolated rat hearts.
The American journal of Chinese medicine 2004;32(4):587-98.
2003: Kenji Hayakawa; Genzou Takemura; Motoo Kanoh; Yiwen Li; Masahiko Koda; Yukinori Kawase; Rumi Maruyama; Hideshi Okada; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Inhibition of granulation tissue cell apoptosis during the subacute stage of myocardial infarction improves cardiac remodeling and dysfunction at the chronic stage.
Circulation 2003;108(1):104-9.
2003: Xuehai Chen; Shinya Minatoguchi; Ningyuan Wang; Masazumi Arai; Cuanjiang Lu; Yoshihiro Uno; Yu Misao; Genzou Takemura; Hisayoshi Fujiwara
Quinaprilat reduces myocardial infarct size involving nitric oxide production and mitochondrial KATP channel in rabbits.
Journal of cardiovascular pharmacology 2003;41(6):938-45.
2003: Yiwen Li; Genzou Takemura; Ken-ichiro Kosai; Kentaro Yuge; Satoshi Nagano; Masayasu Esaki; Kazuko Goto; Tomoyuki Takahashi; Kenji Hayakawa; Masahiko Koda; Yukinori Kawase; Rumi Maruyama; Hideshi Okada; Shinya Minatoguchi; Hiroyuki Mizuguchi; Takako Fujiwara; Hisayoshi Fujiwara
Postinfarction treatment with an adenoviral vector expressing hepatocyte growth factor relieves chronic left ventricular remodeling and dysfunction in mice.
Circulation 2003;107(19):2499-506.
2003: Genzou Takemura; Hisayoshi Fujiwara
[Phenotype alterations of failing myocardium].
Nihon rinsho. Japanese journal of clinical medicine 2003;61(5):731-8.
2003: Masahiko Koda; Genzou Takemura; Motoo Kanoh; Kenji Hayakawa; Yukinori Kawase; Rumi Maruyama; Yiwen Li; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Myocytes positive for in situ markers for DNA breaks in human hearts which are hypertrophic, but neither failed nor dilated: a manifestation of cardiac hypertrophy rather than failure.
The Journal of pathology 2003;199(2):229-36.
2003: Yun-Mo Li; Yasushi Ohno; Shinya Minatoguchi; Kazunori Fukuda; Tetsuro Ikoma; Takamasa Ohno; Seigo Akao; Genzou Takemura; Koushi Gotou; Hisayoshi Fujiwara
Extracts from the roots of Lindera strychifolia induces apoptosis in lung cancer cells and prolongs survival of tumor-bearing mice.
The American journal of Chinese medicine 2003;31(6):857-69.
2003: Shinya Minatoguchi; Yoshihiro Uno; Tatsuya Kariya; Masazumi Arai; Ningyuan Wang; Kazuaki Hashimoto; Yoshio Nishida; Rumi Maruyama; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara
Cross-talk among noradrenaline, adenosine and protein kinase C in the mechanisms of ischemic preconditioning in rabbits.
Journal of cardiovascular pharmacology 2003;41 Suppl 1():S39-47.
2002: Tomoyo Kagawa; Genzou Takemura; Xinbin Qiu; Rumi Maruyama; Ningyuan Wang; Shinya Minatoguchi; Hisayoshi Fujiwara
Hydroxyl radical generation by the combination of iron and ascorbic acid is greatly attenuated but still significant in human gastric juice.
Internal medicine (Tokyo, Japan) 2002;41(12):1213-4.
2002: Yasuko Shimizu; Shinya Minatoguchi; Kazuaki Hashimoto; Yoshihiro Uno; Masazumi Arai; Ningyuan Wang; Xuehai Chen; Chuanjian Lu; Genzou Takemura; Masaaki Shimomura; Takako Fujiwara; Hisayoshi Fujiwara
The role of serotonin in ischemic cellular damage and the infarct size-reducing effect of sarpogrelate, a 5-hydroxytryptamine-2 receptor blocker, in rabbit hearts.
Journal of the American College of Cardiology 2002;40(7):1347-55.
2002: Ichijiro Murata; Genzou Takemura; Kiyoji Asano; Hirotake Sano; Koh Fujisawa; Tomoyo Kagawa; Kaoru Baba; Rumi Maruyama; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Apoptotic cell loss following cell proliferation in renal glomeruli of Otsuka Long-Evans Tokushima Fatty rats, a model of human type 2 diabetes.
American journal of nephrology 2002;22(5-6):587-95.
2002: Takuma Aoyama; Genzou Takemura; Rumi Maruyama; Ken-ichiro Kosai; Tomoyuki Takahashi; Masahiko Koda; Kenji Hayakawa; Yukinori Kawase; Shinya Minatoguchi; Hisayoshi Fujiwara
Molecular mechanisms of non-apoptosis by Fas stimulation alone versus apoptosis with an additional actinomycin D in cultured cardiomyocytes.
Cardiovascular research 2002;55(4):787-98.
2002: Ningyuan Wang; Shinya Minatoguchi; Masazumi Arai; Yoshihiro Uno; Yoshio Nishida; Kazuaki Hashimoto; Chen Xue-Hai; Kazunori Fukuda; Seigo Akao; Genzou Takemura; Hisayoshi Fujiwara
Sheng-Mai-San is protective against post-ischemic myocardial dysfunction in rats through its opening of the mitochondrial KATP channels.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(8):763-8.
2002: Hideto Sano; Yukihiko Ueda; Nobuyuki Takakura; Genzou Takemura; Toshio Doi; Hiroshi Kataoka; Toshinori Murayama; Yang Xu; Tetsuo Sudo; Satomi Nishikawa; Shin-Ichi Nishikawa; Hisayoshi Fujiwara; Toru Kita; Masayuki Yokode
Blockade of platelet-derived growth factor receptor-beta pathway induces apoptosis of vascular endothelial cells and disrupts glomerular capillary formation in neonatal mice.
The American journal of pathology 2002;161(1):135-43.
2002: Kenji Hayakawa; Genzou Takemura; Masahiko Koda; Yukinori Kawase; Rumi Maruyama; Yiwen Li; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Sensitivity to apoptosis signal, clearance rate, and ultrastructure of fas ligand-induced apoptosis in in vivo adult cardiac cells.
Circulation 2002;105(25):3039-45.
2002: Masanori Kawasaki; Hisato Takatsu; Toshiyuki Noda; Keiji Sano; Yoko Ito; Kenji Hayakawa; Kunihiko Tsuchiya; Masazumi Arai; Kazuhiko Nishigaki; Genzou Takemura; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
In vivo quantitative tissue characterization of human coronary arterial plaques by use of integrated backscatter intravascular ultrasound and comparison with angioscopic findings.
Circulation 2002;105(21):2487-92.
2002: Masago Tsuchiya; Kunihiko Tsuchiya; Rumi Maruyama; Genzou Takemura; Shinya Minatoguchi; Hisayoshi Fujiwara
Vasopressin inhibits sarcolemmal ATP-sensitive K+ channels via V1 receptors activation in the guinea pig heart.
Circulation journal : official journal of the Japanese Circulation Society 2002;66(3):277-82.
2002: Masami Miyamae; H Fujiwara; Masaru Tanaka; R Yokota; Genzou Takemura; Shuji Itoh; Naochika Domae; Vincent M Figueredo
Oxygen radicals mediate ultrastructural and metabolic protection of preconditioning in vivo in pig hearts.
Experimental and clinical cardiology 2002;7(4):173-9.
2002: Yukinori Kawase; Genzou Takemura; Kenji Hayakawa; Masahiko Koda; Rumi Maruyama; Motoo Kanoh; Akihisa Kunishima; Masazumi Arai; Shinya Minatoguchi; Tomoko Ohkusa; Masanori Matsuzaki; Takako Fujiwara; Hisayoshi Fujiwara
Abundant apoptosis in nutmeg liver of cardiomyopathic hamsters. Apoptotic cell death as a possible mechanism of hepatic remodeling by congestion.
Pathology, research and practice 2002;198(4):291-8.
2001: Hideto Sano; Masayuki Yokode; Nobuyuki Takakura; Genzou Takemura; Toshio Doi; Hiroharu Kataoka; Tetsuo Sudo; Shin-Ichi Nishikawa; Hisayoshi Fujiwara; S I Nishikawa; Toru Kita
Study on PDGF receptor beta pathway in glomerular formation in neonate mice.
Annals of the New York Academy of Sciences 2001;947():303-5.
2001: M Kawada; Yasushi Ohno; Y Ri; T Ikoma; H Yuugetu; Toshihiro Asai; M Watanabe; N Yasuda; Seigo Akao; Genzou Takemura; Shinya Minatoguchi; K Gotoh; Hisayoshi Fujiwara; Kazunori Fukuda
Anti-tumor effect of gallic acid on LL-2 lung cancer cells transplanted in mice.
Anti-cancer drugs 2001;12(10):847-52.
2001: Shinya Minatoguchi; Tatsuya Kariya; Yoshihiro Uno; Masazumi Arai; Yoshio Nishida; Kazuaki Hashimoto; Ningyuan Wang; T Aoyama; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara
Caspase-dependent and serine protease-dependent DNA fragmentation of myocytes in the ischemia-reperfused rabbit heart: these inhibitors do not reduce infarct size.
Japanese circulation journal 2001;65(10):907-11.
2001: S Kato; Genzou Takemura; R Maruyama; T Aoyama; K Hayakawa; M Koda; Y Kawase; Y Li; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Apoptosis, rather than oncosis, is the predominant mode of spontaneous death of isolated adult rat cardiac myocytes in culture.
Japanese circulation journal 2001;65(8):743-8.
2001: Masanori Kawasaki; H Takatsu; Toshiyuki Noda; Yoko Ito; Akihisa Kunishima; Masazumi Arai; Kazuhiko Nishigaki; Genzou Takemura; N Morita; Shinya Minatoguchi; Hisayoshi Fujiwara
Noninvasive quantitative tissue characterization and two-dimensional color-coded map of human atherosclerotic lesions using ultrasound integrated backscatter: comparison between histology and integrated backscatter images.
Journal of the American College of Cardiology 2001;38(2):486-92.
2001: Shinya Minatoguchi; Ningyuan Wang; Yoshihiro Uno; Masazumi Arai; Kazuaki Hashimoto; Y Hashimoto; Xue-Hai Chen; Genzou Takemura; Hisayoshi Fujiwara
Combination of miglitol, an anti-diabetic drug, and nicorandil markedly reduces myocardial infarct size through opening the mitochondrial K(ATP) channels in rabbits.
British journal of pharmacology 2001;133(7):1041-6.
2001: Rumi Maruyama; Genzou Takemura; Takuma Aoyama; Kenji Hayakawa; Masahiko Koda; Yukinori Kawase; X Qiu; Y Ohno; Shinya Minatoguchi; K Miyata; Takako Fujiwara; Hisayoshi Fujiwara
Dynamic process of apoptosis in adult rat cardiomyocytes analyzed using 48-hour videomicroscopy and electron microscopy: beating and rate are associated with the apoptotic process.
The American journal of pathology 2001;159(2):683-91.
2001: Der-Jinn Wu; Shinya Minatoguchi; Yoshihiro Uno; Masazumi Arai; Ningyuan Wang; Yoshio Nishida; Kazuaki Hashimoto; Y Hashimoto; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara
Combination of N-methyl-1-deoxynojirimycin and ischemic preconditioning markedly reduces the size of myocardial infarcts in rabbits.
Japanese circulation journal 2001;65(7):673-7.
2001: Masazumi Arai; Shinya Minatoguchi; H Kumada; Yoshihiro Uno; Yoshio Nishida; Kazuaki Hashimoto; Ningyuan Wang; Genzou Takemura; Takako Fujiwara; M Higashioka; K Kuwano; Hisayoshi Fujiwara
Role of protein kinase C in the reduction of infarct size by N-methyl-1-deoxynojirimycin, an alpha-1,6-glucosidase inhibitor.
British journal of pharmacology 2001;133(5):635-42.
2001: Genzou Takemura; S Kato; Takuma Aoyama; Y Hayakawa; Motoo Kanoh; Rumi Maruyama; Masazumi Arai; Kazuhiko Nishigaki; Shinya Minatoguchi; Kazunori Fukuda; Takako Fujiwara; Hisayoshi Fujiwara
Characterization of ultrastructure and its relation with DNA fragmentation in Fas-induced apoptosis of cultured cardiac myocytes.
The Journal of pathology 2001;193(4):546-56.
2001: Kazuaki Hashimoto; Shinya Minatoguchi; Y Hashimoto; Ningyuan Wang; Xinbin Qiu; K Yamashita; Yoshihiro Uno; Masazumi Arai; Yoshio Nishida; Genzou Takemura; T Suzuki; Takako Fujiwara; Hisayoshi Fujiwara
Role of protein kinase C, K(ATP) channels and DNA fragmentation in the infarct size-reducing effects of the free radical scavenger T-0970.
Clinical and experimental pharmacology & physiology 2001;28(3):193-9.
2001: M Watanabe; K Gotoh; K Nagashima; Y Uno; Toshiyuki Noda; Kazuhiko Nishigaki; Genzou Takemura; Motoo Kanoh; N Yasuda; Yasushi Ohno; Shinya Minatoguchi; Hisayoshi Fujiwara
Relationship between thallium-201 myocardial SPECT and findings of endomyocardial biopsy specimens in dilated cardiomyopathy.
Annals of nuclear medicine 2001;15(1):13-9.
2000: Shinsuke Ojio; H Takatsu; Tsutomu Tanaka; Katsumi Ueno; Koichi Yokoya; T Matsubara; Takahiko Suzuki; Sachiro Watanabe; Norihiko Morita; Masanori Kawasaki; T Nagano; I Nishio; K Sakai; Kazuhiko Nishigaki; Genzou Takemura; Toshiyuki Noda; Shinya Minatoguchi; Hisayoshi Fujiwara
Considerable time from the onset of plaque rupture and/or thrombi until the onset of acute myocardial infarction in humans: coronary angiographic findings within 1 week before the onset of infarction.
Circulation 2000;102(17):2063-9.
2000: K Yamashita; Shinya Minatoguchi; Yoshihiro Uno; Tatsuya Kariya; M Ohno; Masazumi Arai; Kazuaki Hashimoto; Yoshio Nishida; K Nagashima; Xinbin Qiu; Genzou Takemura; T Suzuki; Takako Fujiwara; Hisayoshi Fujiwara
T-0162, a novel free radical scavenger, reduces myocardial infarct size in rabbits.
Clinical and experimental pharmacology & physiology 2000;27(3):172-8.
2000: Yoshio Nishida; Shinya Minatoguchi; Masazumi Arai; Genzou Takemura; Yoshihiro Uno; Kazuaki Hashimoto; Ningyuan Wang; X H Chen; Takako Fujiwara; Hisayoshi Fujiwara
N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly improves postischemic left ventricular dysfunction.
Heart and vessels 2000;15(6):268-73.
2000: X Qiu; Genzou Takemura; M Koshiji; Y Hayakawa; Motoo Kanoh; Rumi Maruyama; Yasushi Ohno; Shinya Minatoguchi; Seigo Akao; Kazunori Fukuda; Takako Fujiwara; Hisayoshi Fujiwara
Gallic acid induces vascular smooth muscle cell death via hydroxyl radical production.
Heart and vessels 2000;15(2):90-9.
2000: Genzou Takemura; Hisayoshi Fujiwara
[Endomyocardial biopsy: procedure and pathology].
Nihon rinsho. Japanese journal of clinical medicine 2000;58(1):53-8.
1999: Shinya Minatoguchi; Masazumi Arai; Yoshihiro Uno; Tatsuya Kariya; Yoshio Nishida; Kazuaki Hashimoto; M Kawasaki; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara
A novel anti-diabetic drug, miglitol, markedly reduces myocardial infarct size in rabbits.
British journal of pharmacology 1999;128(8):1667-72.
1999: Yasushi Ohno; Kazunori Fukuda; Genzou Takemura; M Toyota; M Watanabe; N Yasuda; Q Xinbin; Rumi Maruyama; Seigo Akao; Koushi Gotou; Takako Fujiwara; Hisayoshi Fujiwara
Induction of apoptosis by gallic acid in lung cancer cells.
Anti-cancer drugs 1999;10(9):845-51.
1999: Y Hayakawa; Genzou Takemura; J Misao; Motoo Kanoh; M Ohno; H Ohashi; H Takatsu; H Ito; Kazunori Fukuda; Takako Fujiwara; Shinya Minatoguchi; Hisayoshi Fujiwara
Apoptosis and overexpression of bax protein and bax mRNA in smooth muscle cells within intimal hyperplasia of human radial arteries : analysis with arteriovenous fistulas used for hemodialysis.
Arteriosclerosis, thrombosis, and vascular biology 1999;19(9):2066-77.
1999: Koichi Yokoya; H Takatsu; Takahiko Suzuki; Hiroaki Hosokawa; Shinsuke Ojio; T Matsubara; Tsutomu Tanaka; Sachiro Watanabe; Norihiko Morita; Kazuhiko Nishigaki; Genzou Takemura; Toshiyuki Noda; Shinya Minatoguchi; Hisayoshi Fujiwara
Process of progression of coronary artery lesions from mild or moderate stenosis to moderate or severe stenosis: A study based on four serial coronary arteriograms per year.
Circulation 1999;100(9):903-9.
1999: R Murata; H Takatsu; Toshiyuki Noda; Kazuhiko Nishigaki; Kunihiko Tsuchiya; Genzou Takemura; Motoo Kanoh; Akihisa Kunishima; K Sano; Shinya Minatoguchi; H Takagi; Hisayoshi Fujiwara
Fifteen-year follow-up of a heterozygous Fabry's disease patient associated with pre-excitation syndrome.
Internal medicine (Tokyo, Japan) 1999;38(6):476-81.
1999: Motoo Kanoh; Genzou Takemura; J Misao; Y Hayakawa; Takuma Aoyama; Kazuhiko Nishigaki; Toshiyuki Noda; Takako Fujiwara; Kazunori Fukuda; Shinya Minatoguchi; Hisayoshi Fujiwara
Significance of myocytes with positive DNA in situ nick end-labeling (TUNEL) in hearts with dilated cardiomyopathy: not apoptosis but DNA repair.
Circulation 1999;99(21):2757-64.
1999: Akihisa Kunishima; Genzou Takemura; H Takatsu; Y Hayakawa; Motoo Kanoh; X Qiu; Takako Fujiwara; Hisayoshi Fujiwara
Mode and role of cell death during progression of atherosclerotic lesions in hypercholesterolemic rabbits.
Heart and vessels 1999;14(6):295-306.
1998: K Doyama; M Fukumoto; Genzou Takemura; Mari Tanaka; T Oda; Koji Hasegawa; T Inada; S Ohtani; T Fujiwara; H Itoh; K Nakao; Shigetake Sasayama; H Fujiwara
Expression and distribution of brain natriuretic peptide in human right atria.
Journal of the American College of Cardiology 1998;32(7):1832-8.
1998: M Ohno; Genzou Takemura; A Ohno; J Misao; Y Hayakawa; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
"Apoptotic" myocytes in infarct area in rabbit hearts may be oncotic myocytes with DNA fragmentation: analysis by immunogold electron microscopy combined with In situ nick end-labeling.
Circulation 1998;98(14):1422-30.
1998: Genzou Takemura; M Ohno; Y Hayakawa; J Misao; Motoo Kanoh; A Ohno; Y Uno; Shinya Minatoguchi; Takako Fujiwara; Hisayoshi Fujiwara
Role of apoptosis in the disappearance of infiltrated and proliferated interstitial cells after myocardial infarction.
Circulation research 1998;82(11):1130-8.
1998: J Hiraoka; K Asano; H Sano; K Fujisawa; M Ohno; Genzou Takemura; Shinya Minatoguchi; H Ohashi; Takako Fujiwara; Hisayoshi Fujiwara
[Participation of apoptosis in renal amyloidosis].
Nihon Jinzo Gakkai shi 1998;40(4):276-83.
1998: Masazumi Arai; Shinya Minatoguchi; Genzou Takemura; Yoshihiro Uno; Tatsuya Kariya; Hisato Takatsu; Takako Fujiwara; M Higashioka; Y Yoshikuni; Hisayoshi Fujiwara
N-methyl-1-deoxynojirimycin (MOR-14), an alpha-glucosidase inhibitor, markedly reduced infarct size in rabbit hearts.
Circulation 1998;97(13):1290-7.
1998: Genzou Takemura; Yoshiki Takatsu; K Doyama; H Itoh; Y Saito; M Koshiji; F Ando; T Fujiwara; K Nakao; H Fujiwara
Expression of atrial and brain natriuretic peptides and their genes in hearts of patients with cardiac amyloidosis.
Journal of the American College of Cardiology 1998;31(4):754-65.
1998: Genzou Takemura; Yoshiki Takatsu; H Fujiwara
Luminal narrowing of coronary capillaries in human hypertrophic hearts: an ultrastructural morphometrical study using endomyocardial biopsy specimens.
Heart (British Cardiac Society) 1998;79(1):78-85.
1997: Genzou Takemura; Yoshiki Takatsu; H Sakaguchi; H Fujiwara
Intranuclear mitochondria in human myocardial cells.
Pathology, research and practice 1997;193(4):305-11.
1996: N Yasuda; M Kohda; M Nomura; K Nagashima; Genzou Takemura; H Takatsu; Shinya Minatoguchi; K Gotoh; Hisayoshi Fujiwara
[Sarcoidosis in a patient with autoimmune hemolytic anemia].
Nihon Kyōbu Shikkan Gakkai zasshi 1996;34(8):931-6.
1996: Hiroyuki Koshiyama; Donald F Sellitti; Takashi Akamizu; Sonia Q Doi; Y Takeuchi; D Inoue; H Sakaguchi; Genzou Takemura; Yukihito Sato; Yoshiki Takatsu; Kazuwa Nakao
Cardiomyopathy associated with Graves' disease.
Clinical endocrinology 1996;45(1):111-6.
1996: Genzou Takemura; Yoshiki Takatsu; K Kaitani; M Ono; F Ando; S Tanada; H Niwa; H Tankawa; T Fujiwara; H Yamabe
Metastasizing uterine leiomyoma. A case with cardiac and pulmonary metastasis.
Pathology, research and practice 1996;192(6):622-9; discussion 630-3.
1995: Genzou Takemura; H Fujiwara; Yoshiki Takatsu; T Fujiwara; Kazuwa Nakao
Venticular expression of atrial and brain natriuretic peptides in patients with myocarditis.
International journal of cardiology 1995;52(3):213-22.
1995: Genzou Takemura; Yoshiki Takatsu; K Ono; T Miyatake; M Ono; T Izumi; H Fujiwara
Usefulness of electron microscopy in the diagnosis of cardiac sarcoidosis.
Heart and vessels 1995;10(5):275-8.
1991: M Matsuda; H Fujiwara; A Kawamura; M Ishida; Genzou Takemura; M Kida; T Uegaito; Y Fujiwara; T Fujiwara; Chuichi Kawai
Failure to reduce infarct size by intracoronary infusion of recombinant human superoxide dismutase at reperfusion in the porcine heart: immunohistochemical and histological analysis.
Journal of molecular and cellular cardiology 1991;23(11):1287-96.
1991: T Uegaito; H Fujiwara; M Ishida; A Kawamura; Genzou Takemura; M Kida; M Tanaka; Chuichi Kawai
Hypertrophy of surviving myocytes overlying the infarct in human old myocardial infarctions with abnormal Q waves.
International journal of cardiology 1991;32(1):93-101.
1991: K Horike; H Fujiwara; M Matsuda; A Kawamura; M Ishida; Genzou Takemura; M Kida; T Uegaito; M Tanaka; Akira Matsumori
Relation between myoglobin and cardiac dysfunction in myocarditis--immunohistochemical study of endomyocardial biopsy specimens.
Japanese circulation journal 1991;55(1):24-32.
1991: Genzou Takemura; H Fujiwara; K Horike; Chuichi Kawai; Masashi Mukoyama; Yoshihiko Saito; Kazuwa Nakao; Hiroshi Imura; T Fujiwara
[Expression of atrial natriuretic polypeptide in ventricles of heart with hypertrophic cardiomyopathy: an immunohistochemical study of endomyocardial specimens].
Journal of cardiology 1991;21(3):641-7.
1991: Genzou Takemura; H Fujiwara; Masashi Mukoyama; Yoshihiko Saito; Kazuwa Nakao; A Kawamura; M Ishida; M Kida; T Uegaito; M Tanaka
Expression and distribution of atrial natriuretic peptide in human hypertrophic ventricle of hypertensive hearts and hearts with hypertrophic cardiomyopathy.
Circulation 1991;83(1):181-90.
1990: A Kawamura; H Fujiwara; M Ishida; Genzou Takemura; M Kida; T Uegaito; M Tanaka; Chuichi Kawai
Protective effects of nipradilol, isosorbide dinitrate, and bunazosin on coronary artery constriction induced by intracoronary injection of acetylcholine in pigs.
Cardiovascular research 1990;24(12):1013-9.
1990: Genzou Takemura; H Fujiwara; H Yoshida; Masashi Mukoyama; Yoshihiko Saito; Kazuwa Nakao; T Fujiwara; T Uegaito; H Imura; Chuichi Kawai
Identification and distribution of atrial natriuretic polypeptide in ventricular myocardium of humans with myocardial infarction.
The Journal of pathology 1990;161(4):285-92.
1990: D J Wu; H Fujiwara; M Matsuda; M Ishida; A Kawamura; Genzou Takemura; M Kida; T Uegaito; T Fujiwara; Chuichi Kawai
Clinicopathological study of myocardial infarction with normal or nearly normal extracardiac coronary arteries. Quantitative analysis of contraction band necrosis, coagulation necrosis, hemorrhage, and infarct size.
Heart and vessels 1990;6(1):55-62.
1989: A Kawamura; H Fujiwara; T Onodera; D J Wu; M Matsuda; M Ishida; Genzou Takemura; Y Fujiwara; Chuichi Kawai
Response of large and small coronary arteries of pigs to intracoronary injection of acetylcholine: angiographic and histologic analysis.
International journal of cardiology 1989;25(3):289-302.
1989: Genzou Takemura; H Fujiwara; H Yoshida; D J Wu; M Matsuda; M Ishida; A Kawamura; T Fujiwara; Chuichi Kawai
High frequency of spontaneous acute myocardial infarction due to small coronary artery disease in dead (NZWxBXSB)F1 male mice.
The American journal of pathology 1989;135(6):989-99.
1989: Genzou Takemura; H Fujiwara; K Horike; Masashi Mukoyama; Yoshihiko Saito; Kazuwa Nakao; M Matsuda; A Kawamura; M Ishida; M Kida
Ventricular expression of atrial natriuretic polypeptide and its relations with hemodynamics and histology in dilated human hearts. Immunohistochemical study of the endomyocardial biopsy specimens.
Circulation 1989;80(5):1137-47.
1989: H Fujiwara; M Matsuda; Y Fujiwara; M Ishida; A Kawamura; Genzou Takemura; M Kida; T Uegaito; M Tanaka; K Horike
Infarct size and the protection of ischemic myocardium in pig, dog and human.
Japanese circulation journal 1989;53(9):1092-7.
1989: M Tanaka; H Fujiwara; M Ishida; M Kida; T Onodera; D J Wu; M Matsuda; A Kawamura; Genzou Takemura; Chuichi Kawai
Influence of propranolol on high energy phosphate and tissue acidosis in regional ischemic myocardium of pigs: assessment with arterial pressure and respiration gated in vivo 31-phosphorus magnetic resonance spectroscopy.
International journal of cardiology 1989;24(2):165-72.
1989: Genzou Takemura; H Fujiwara; Masashi Mukoyama; Yoshihiko Saito; M Matsuda; A Kawamura; M Ishida; M Kida; T Uegaito; Kazuwa Nakao
Immunohistochemical localization and semi-quantification of atrial natriuretic polypeptide (ANP) in formalin-fixed-paraffin-embedded normal human hearts--comparative study with radioimmunoassay.
Japanese circulation journal 1989;53(7):686-94.
1989: T Onodera; H Fujiwara; M Tanaka; D J Wu; M Matsuda; M Ishida; A Kawamura; Genzou Takemura; Chuichi Kawai
[Correlations between results of selective intracoronary thrombolysis and histologic findings of the infarct-related coronary arteries].
Journal of cardiology 1989;19(2):387-91.
1989: T Onodera; H Fujiwara; M Tanaka; D J Wu; M Matsuda; Genzou Takemura; M Ishida; A Kawamura; Chuichi Kawai
Cineangiographic and pathological features of the infarct related vessel in successful and unsuccessful thrombolysis.
British heart journal 1989;61(5):385-9.
1989: H Fujiwara; T Onodera; M Tanaka; S Miyazaki; D J Wu; M Matsuda; A Kawamura; M Ishida; Genzou Takemura; Y Fujiwara
Acceleration of cell necrosis following reperfusion after ischemia in the pig heart without collateral circulation.
The American journal of cardiology 1989;63(10):14E-18E.
1988: D J Wu; H Fujiwara; M Tanaka; T Onodera; M Matsuda; M Ishida; A Kawamura; Genzou Takemura; T Fujiwara; Y Nagano
Distribution and progression of coronary arterial and aortic lesions in the conventional Watanabe heritable hyperlipidemic rabbit--quantitative analysis.
Japanese circulation journal 1988;52(4):327-40.