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Keizo Takenaga

Research Profile

Living Beings

Anatomy

Tumor Cells, Cultured

Procedures

Chemicals & Drugs

Disorders

Colonic Neoplasms

Physiology

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Publications

TOP 3
Yanqing Wang; Mika Seimiya; Kiyoko Kawamura; Ling Yu; Tomoo Ogi; Keizo Takenaga; Tomotane Shishikura; Akira Nakagawara; Shigeru Sakiyama; Masatoshi Tagawa; Jiyang O-Wang
Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53.
Nobuko Koshikawa; Ayako Iyozumi; Max Gassmann; Keizo Takenaga
Constitutive upregulation of hypoxia-inducible factor-1alpha mRNA occurring in highly metastatic lung carcinoma cells leads to vascular endothelial growth factor overexpression upon hypoxic exposure.
Yuji Tada; Jiyang O-Wang; Ling Yu; Osamu Shimozato; Yan-Qing Wang; Yuichi Takiguchi; Koichiro Tatsumi; Takayuki Kuriyama; Keizo Takenaga; Shigeru Sakiyama; Masatoshi Tagawa
T-cell-dependent antitumor effects produced by CD40 ligand expressed on mouse lung carcinoma cells are linked with the maturation of dendritic cells and secretion of a variety of cytokines.

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All Publications

2004: Yanqing Wang; Mika Seimiya; Kiyoko Kawamura; Ling Yu; Tomoo Ogi; Keizo Takenaga; Tomotane Shishikura; Akira Nakagawara; Shigeru Sakiyama; Masatoshi Tagawa; Jiyang O-Wang
Elevated expression of DNA polymerase kappa in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53.
International journal of oncology 2004;25(1):161-5.
2003: Nobuko Koshikawa; Ayako Iyozumi; Max Gassmann; Keizo Takenaga
Constitutive upregulation of hypoxia-inducible factor-1alpha mRNA occurring in highly metastatic lung carcinoma cells leads to vascular endothelial growth factor overexpression upon hypoxic exposure.
Oncogene 2003;22(43):6717-24.
2003: Yuji Tada; Jiyang O-Wang; Ling Yu; Osamu Shimozato; Yan-Qing Wang; Yuichi Takiguchi; Koichiro Tatsumi; Takayuki Kuriyama; Keizo Takenaga; Shigeru Sakiyama; Masatoshi Tagawa
T-cell-dependent antitumor effects produced by CD40 ligand expressed on mouse lung carcinoma cells are linked with the maturation of dendritic cells and secretion of a variety of cytokines.
Cancer gene therapy 2003;10(6):451-6.
2002: Yuji Tada; Jiyang O-Wang; Keizo Takenaga; Yuichi Takiguchi; Koichiro Tatsumi; Takayuki Kuriyama; Masatoshi Tagawa
Expression of the TNF-alpha gene on mouse lung carcinoma cells suppresses spontaneous lung metastasis without affecting tumorigenicity.
Oncology reports 2002;9(3):585-8.
2001: Kiyoko Kawamura; Rumana Bahar; H Namba; Mika Seimiya; Keizo Takenaga; H Hamada; Shigeru Sakiyama; Masatoshi Tagawa
Bystander effect in uracil phosphoribosyltransferase/5-fluorouracil-mediated suicide gene therapy is correlated with the level of intercellular communication.
International journal of oncology 2001;18(1):117-20.
2000: N Koshikawa; Keizo Takenaga; Masatoshi Tagawa; Shigeru Sakiyama
Therapeutic efficacy of the suicide gene driven by the promoter of vascular endothelial growth factor gene against hypoxic tumor cells.
Cancer research 2000;60(11):2936-41.
2000: Kiyoko Kawamura; K Tasaki; H Hamada; Keizo Takenaga; Shigeru Sakiyama; Masatoshi Tagawa
Expression of Escherichia coli uracil phosphoribosyltransferase gene in murine colon carcinoma cells augments the antitumoral effect of 5-fluorouracil and induces protective immunity.
Cancer gene therapy 2000;7(4):637-43.
2000: Yu Yoshida; K Tasaki; M Miyauchi; M Narita; Keizo Takenaga; Hiroshi Yamamoto; T Yaaguchi; Hiromitsu Saisho; Shigeru Sakiyama; Masatoshi Tagawa
Impaired tumorigenicity of human pancreatic cancer cells retrovirally transduced with interleukin-12 or interleukin-15 gene.
Cancer gene therapy 2000;7(2):324-31.
2000: K Tasaki; Yu Yoshida; M Miyauchi; T Maeda; Keizo Takenaga; Teruo Kouzu; Takehide Asano; Takenori Ochiai; S Sakiyamna; Masatoshi Tagawa
Transduction of murine colon carcinoma cells with interleukin-15 gene induces antitumor effects in immunocompetent and immunocompromised hosts.
Cancer gene therapy 2000;7(2):255-61.
2000: K Tasaki; Yu Yoshida; T Maeda; M Miyauchi; Kiyoko Kawamura; Keizo Takenaga; Hiroshi Yamamoto; Teruo Kouzu; Takehide Asano; Takenori Ochiai; Shigeru Sakiyama; Masatoshi Tagawa
Protective immunity is induced in murine colon carcinoma cells by the expression of interleukin-12 or interleukin-18, which activate type 1 helper T cells.
Cancer gene therapy 2000;7(2):247-54.
1999: Hisahiro Matsubara; Kiyoko Kawamura; M Sugaya; Y Koide; Yoshio Gunji; Keizo Takenaga; Takehide Asano; Takenori Ochiai; Shigeru Sakiyama; Masatoshi Tagawa
Differential efficacy of suicide gene therapy by herpes simplex virus-thymidine kinase gene reflects the status of p53 gene in human esophageal cancer cells.
Anticancer research 1999;19(5B):4157-60.
1999: H Yoshida; M Tanabe; M Miyauchi; Kiyoko Kawamura; Keizo Takenaga; N Ohnuma; Shigeru Sakiyama; Masatoshi Tagawa
Induced immunity by expression of interleukin-2 or GM-CSF gene in murine neuroblastoma cells can generate antitumor response to established tumors.
Cancer gene therapy 1999;6(5):395-401.
1999: M Miyauchi; Hideaki Shimada; Kenji Kadomatsu; Takashi Muramatsu; S Matsubara; Shinya Ikematsu; Keizo Takenaga; Takehide Asano; Takenori Ochiai; Shigeru Sakiyama; Masatoshi Tagawa
Frequent expression of midkine gene in esophageal cancer suggests a potential usage of its promoter for suicide gene therapy.
Japanese journal of cancer research : Gann 1999;90(4):469-75.
1998: Yoshio Gunji; K Tasaki; Masatoshi Tagawa; Hisahiro Matsubara; Keizo Takenaga; Takeo Suzuki; Takehide Asano; Takenori Ochiai; Kaichi Isono; Shigeru Sakiyama
Inhibition of peritoneal dissemination of murine colon carcinoma cells by administrating retrovirus harboring IL-2 gene.
Cancer gene therapy 1998;5(6):339-43.
1998: H Yoshida; H Enomoto; Kiyoko Kawamura; Keizo Takenaga; M Tanabe; N Ohnuma; Shigeru Sakiyama; Masatoshi Tagawa
Antitumor vaccine effect of irradiated murine neuroblastoma cells producing interleukin-2 or granulocyte macrophage-colony stimulating factor.
International journal of oncology 1998;13(1):73-8.
1998: K Tasaki; Yoshio Gunji; Hisahiro Matsubara; Keizo Takenaga; Takeo Suzuki; Takehide Asano; Takenori Ochiai; Kaichi Isono; Teruo Kouzu; Shigeru Sakiyama; Masatoshi Tagawa
Induction of T cell dependent acquired immunity in syngeneic mice by the combined expression of interleukin-4 and granulocyte macrophage-colony stimulating factor gene in murine colon carcinoma cells.
Anticancer research 1998;18(3A):1453-6.
1998: H Yoshida; H Enomoto; M Miyauchi; Keizo Takenaga; M Tanabe; N Ohnuma; Shigeru Sakiyama; Masatoshi Tagawa
Impaired tumorigenicity of IL-4-producing murine neuroblastoma cells in immunodeficient nude mice.
International journal of oncology 1998;12(5):1067-71.
1998: K Tasaki; Masatoshi Tagawa; Yoshio Gunji; Hisahiro Matsubara; Keizo Takenaga; M Muramatsu; S Fujimura; Takeo Suzuki; Takehide Asano; Takenori Ochiai; Kaichi Isono; Teruo Kouzu; Shigeru Sakiyama
Inhibition of experimental lung metastasis of murine colon carcinoma cells depends on the amount of interleukin-2 secreted from the transduced cells.
Anticancer research 1998;18(2A):813-7.
1998: H Yoshida; H Enomoto; Masatoshi Tagawa; Keizo Takenaga; K Tasaki; A Nakagawara; N Ohnuma; H Takahashi; Shigeru Sakiyama
Impaired tumorigenicity and decreased liver metastasis of murine neuroblastoma cells engineered to secrete interleukin-2 or granulocyte macrophage colony-stimulating factor.
Cancer gene therapy 1998;5(2):67-73.
1998: M Sugaya; Masatoshi Tagawa; Hisahiro Matsubara; Yoshio Gunji; Keizo Takenaga; T Maeda; Y Koide; Takehide Asano; Takenori Ochiai; K Isono; Shigeru Sakiyama
Induction of antitumor effect on human esophageal carcinoma cells by the retroviral expression of granulocyte macrophage-colony stimulating factor gene.
International journal of oncology 1998;12(2):321-4.
1998: Yu Yoshida; K Tasaki; M Kimurai; Keizo Takenaga; Hiroshi Yamamoto; Taketo Yamaguchi; Hiromitsu Saisho; Shigeru Sakiyama; Masatoshi Tagawa
Antitumor effect of human pancreatic cancer cells transduced with cytokine genes which activate Th1 helper T cells.
Anticancer research 1998;18(1A):333-5.
1998: M Kimura; Masatoshi Tagawa; Yu Yoshida; T Takenouchi; Keizo Takenaga; K Azuma; Taketo Yamaguchi; Hiromitsu Saisho; Shigeru Sakiyama
Impaired in vivo tumor growth of human pancreatic carcinoma cells retrovirally transduced with GM-CSF gene.
Anticancer research 1998;18(1A):165-70.
1997: K Tasaki; Yu Yoshida; Masatoshi Tagawa; Keizo Takenaga; Takehide Asano; Takenori Ochiai; Kaichi Isono; Teruo Kouzu; Hiromitsu Saisho; Shigeru Sakiyama
Discordant production of released exogenous protein and infectious virions from retrovirus-packaging cells used for gene transduction.
Anticancer research 1997;17(6D):4415-7.
1997: Yasuo Iwadate; H Namba; Masatoshi Tagawa; Keizo Takenaga; K Sueyoshi; Shigeru Sakiyama
Induction of acquired immunity in rats that have eliminated intracranial gliosarcoma cells by the expression of herpes simplex virus-thymidine kinase gene and ganciclovir administration.
Oncology 1997;54(4):329-34.
1997: M Kimura; Masatoshi Tagawa; Keizo Takenaga; Taketo Yamaguchi; Hiromitsu Saisho; Akira Nakagawara; Shigeru Sakiyama
Inability to induce the alteration of tumorigenicity and chemosensitivity of p53-null human pancreatic carcinoma cells after the transduction of wild-type p53 gene.
Anticancer research 1997;17(2A):879-83.
1997: Y Gunji; Masatoshi Tagawa; H Matsubara; Keizo Takenaga; H Shimada; Fukuo Kondo; T Suzuki; K Nakajima; M Sugaya; T Asano; Takenori Ochiai; K Isono; H Kageyama; Y Nakamura; Shigeru Sakiyama
Antitumor effect of murine colon carcinoma cells retrovirally transduced with interleukin-4 and granulocyte macrophage-colony stimulating factor genes.
Oncology 1997;54(1):69-73.
1996: Yoshio Gunji; Masatoshi Tagawa; Hisahiro Matsubara; Keizo Takenaga; M Sugaya; K Tasaki; T Maeda; F Kondo; K Nakajima; Takeo Suzuki; Takehide Asano; Takenori Ochiai; K Isono; Shigeru Sakiyama
Inhibition of peritoneal dissemination of colon carcinoma in syngeneic mice immunized with interleukin-2-producing cells.
Cancer letters 1996;109(1-2):171-6.
1996: Yoshio Gunji; Masatoshi Tagawa; Hisahiro Matsubara; Keizo Takenaga; H Shimada; F Kondo; Takeo Suzuki; K Nakajima; M Sugaya; Takehide Asano; Takenori Ochiai; K Isono; K Horitsu; H Kageyama; Y Nakamura; Shigeru Sakiyama
Antitumor effect induced by the expression of granulocyte macrophage-colony stimulating factor gene in murine colon carcinoma cells.
Cancer letters 1996;101(2):257-61.
1996: Hisahiro Matsubara; Masatoshi Tagawa; Yoshio Gunji; Keizo Takenaga; M Sugaya; T Urashima; Y Koide; Takeo Suzuki; Takehide Asano; Takenori Ochiai; K Isono; H Kageyama; Y Nakamura; Shigeru Sakiyama
Study of irradiation effects on cytokine secretion from retrovirally-transduced tumor cells: a model for tumor vaccination.
Anticancer research 1996;16(2):645-50.

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