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Osamu Takeuchi

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Takashi Satoh; Nobuyuki Takakura; Naoki Takemura; Osamu Takeuchi; Masahiro Yamamoto; Yoshichika Yoshioka; Hiroyasu Kidoya; Eiichi Morii; Hisamichi Naito; Katsuhiro Nakagawa; Shizuo Akira
Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.
Kenta Maruyama; Tatsuya Saitoh; Daron Standley; Nobuyuki Takakura; Osamu Takeuchi; Alexis Vandenbon; Kazunari K Yokoyama; Masahiro Fukasaka; Takumi Kawasaki; Hiroyasu Kidoya; Takeshi Kondo; Shizuo Akira
The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.
Takayuki Abe; Shizuo Akira; Takasuke Fukuhara; Taro Kawai; Yoshihiko Maehara; Kohji Moriishi; Akinori Ninomiya; Osamu Takeuchi; Xiauyu Wen; Yoshiharu Matsuura
CD44 participates in IP-10 induction in cells in which hepatitis C virus RNA is replicating, through an interaction with Toll-like receptor 2 and hyaluronan.

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All Publications

2013: Takashi Satoh; Nobuyuki Takakura; Naoki Takemura; Osamu Takeuchi; Masahiro Yamamoto; Yoshichika Yoshioka; Hiroyasu Kidoya; Eiichi Morii; Hisamichi Naito; Katsuhiro Nakagawa; Shizuo Akira
Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages.
Nature 2013;495(7442):524-8.
2012: Kenta Maruyama; Tatsuya Saitoh; Daron Standley; Nobuyuki Takakura; Osamu Takeuchi; Alexis Vandenbon; Kazunari K Yokoyama; Masahiro Fukasaka; Takumi Kawasaki; Hiroyasu Kidoya; Takeshi Kondo; Shizuo Akira
The transcription factor Jdp2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.
Immunity 2012;37(6):1024-36.
2012: Takayuki Abe; Shizuo Akira; Takasuke Fukuhara; Taro Kawai; Yoshihiko Maehara; Kohji Moriishi; Akinori Ninomiya; Osamu Takeuchi; Xiauyu Wen; Yoshiharu Matsuura
CD44 participates in IP-10 induction in cells in which hepatitis C virus RNA is replicating, through an interaction with Toll-like receptor 2 and hyaluronan.
Journal of virology 2012;86(11):6159-70.
2011: Hidenori Iwasaki; Kanako Kuniyoshi; Kazufumi Matsushita; Mutsuyoshi Matsushita; Tatsuya Saitoh; Takashi Satoh; Daron M Standley; Osamu Takeuchi; Shunsuke Teraguchi; Takuya Uehata; Shizuo Akira
The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR-IL-1R by controlling degradation of regnase-1.
Nature immunology 2011;12(12):1167-75.
2011: Akira R Kinjo; Yutaro Kumagai; Huy Dinh; Osamu Takeuchi; Daron M Standley
Functional characterization of protein domains common to animal viruses and mouse.
BMC genomics 2011;12 Suppl 3():S21.
2011: Tatsuya Saitoh; Takashi Satoh; Naoki Yamamoto; Satoshi Uematsu; Osamu Takeuchi; Taro Kawai; Shizuo Akira
Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.
Immunity 2011;34(3):352-63.
2010: Osamu Takeuchi
[Regulation of immune responses by mRNA stability control].
Seikagaku. The Journal of Japanese Biochemical Society 2010;82(12):1124-8.
2010: Tohru Miyake; Takashi Satoh; Hiroki Kato; Kazufumi Matsushita; Yutaro Kumagai; Alexis Vandenbon; Tohru Tani; Tatsushi Muta; Shizuo Akira; Osamu Takeuchi
IκBζ is essential for natural killer cell activation in response to IL-12 and IL-18.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(41):17680-5.
2010: Takashi Satoh; Osamu Takeuchi; Alexis Vandenbon; Koubun Yasuda; Yoshiaki Tanaka; Yutaro Kumagai; Tohru Miyake; Kazufumi Matsushita; Toshihiko Okazaki; Tatsuya Saitoh; Kiri Honma; Toshifumi Matsuyama; Katsuyuki Yui; Tohru Tsujimura; Daron M Standley; Kenji Nakanishi; Kenta Nakai; Shizuo Akira
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection.
Nature immunology 2010;11(10):936-44.
2010: Osamu Takeuchi; Shizuo Akira
Pattern recognition receptors and inflammation.
Cell 2010;140(6):805-20.
2010: Takashi Satoh; Hiroki Kato; Yutaro Kumagai; Mitsutoshi Yoneyama; Shintaro Sato; Kazufumi Matsushita; Tohru Tsujimura; Takashi Fujita; Shizuo Akira; Osamu Takeuchi
LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses.
Proceedings of the National Academy of Sciences of the United States of America 2010;107(4):1512-7.
2009: Tatsuya Saitoh; Naonobu Fujita; Takuya Hayashi; Keigo Takahara; Takashi Satoh; Hanna Lee; Kohichi Matsunaga; Shun Kageyama; Hiroko Omori; takeshi noda; N Yamamoto; Taro Kawai; Ken Ishii; Osamu Takeuchi; Tamotsu Yoshimori; Shizuo Akira
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response.
Proceedings of the National Academy of Sciences of the United States of America 2009;106(49):20842-6.
2009: Tatsukata Kawagoe; Osamu Takeuchi; Yoshitsugu Takabatake; Hiroki Kato; Yoshitaka Isaka; Tohru Tsujimura; Shizuo Akira
TANK is a negative regulator of Toll-like receptor signaling and is critical for the prevention of autoimmune nephritis.
Nature immunology 2009;10(9):965-72.
2009: Takayuki Abe; Yuuki Kaname; Xiaoyu Wen; Hideki Tani; Kohji Moriishi; Satoshi Uematsu; Osamu Takeuchi; Ken J Ishii; Taro Kawai; Shizuo Akira; Yoshiharu Matsuura
Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner.
Journal of virology 2009;83(15):7629-40.
2009: Kazufumi Matsushita; Osamu Takeuchi; Daron M Standley; Yutaro Kumagai; Tatsukata Kawagoe; Tohru Miyake; Takashi Satoh; Hiroki Kato; Tohru Tsujimura; Haruki Nakamura; Shizuo Akira
Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay.
Nature 2009;458(7242):1185-90.
2009: Yutaro Kumagai; Himanshu Kumar; Shohei Koyama; Taro Kawai; Osamu Takeuchi; Shizuo Akira
Cutting Edge: TLR-Dependent viral recognition along with type I IFN positive feedback signaling masks the requirement of viral replication for IFN-{alpha} production in plasmacytoid dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2009;182(7):3960-4.
2009: Osamu Takeuchi; Shizuo Akira
Innate immunity to virus infection.
Immunological reviews 2009;227(1):75-86.
2008: Tatsuya Saitoh; Naonobu Fujita; Myoung Ho Jang; Satoshi Uematsu; Bo-Gie Yang; Takashi Satoh; Hiroko Omori; takeshi noda; Naoki Yamamoto; Masaaki Komatsu; Keiji Tanaka; Taro Kawai; Tohru Tsujimura; Osamu Takeuchi; Tamotsu Yoshimori; Shizuo Akira
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
Nature 2008;456(7219):264-8.
2008: Hiroki Kato; Osamu Takeuchi; Eriko Mikamo-Satoh; Reiko Hirai; Tomoji Kawai; Kazufumi Matsushita; Akane Hiiragi; Terence S Dermody; Takashi Fujita; Shizuo Akira
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5.
The Journal of experimental medicine 2008;205(7):1601-10.
2008: Yutaro Kumagai; Osamu Takeuchi; Shizuo Akira
TLR9 as a key receptor for the recognition of DNA.
Advanced drug delivery reviews 2008;60(7):795-804.
2008: Yutaro Kumagai; Osamu Takeuchi; Shizuo Akira
Pathogen recognition by innate receptors.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2008;14(2):86-92.
2008: Ken J Ishii; Tatsukata Kawagoe; Shohei Koyama; Kosuke Matsui; Himanshu Kumar; Taro Kawai; Satoshi Uematsu; Osamu Takeuchi; Fumihiko Takeshita; Cevayir Coban; Shizuo Akira
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
Nature 2008;451(7179):725-9.
2008: Osamu Takeuchi; Shizuo Akira
MDA5/RIG-I and virus recognition.
Current opinion in immunology 2008;20(1):17-22.
2008: Rabindra N Bhattacharjee; Kwon-Sam Park; Xiuhao Chen; Tetsuya Iida; Takeshi Honda; Osamu Takeuchi; Shizuo Akira
Translocation of VP1686 upregulates RhoB and accelerates phagocytic activity of macrophage through actin remodeling.
Journal of microbiology and biotechnology 2008;18(1):171-5.
2008: Andreas Jung; Hiroki Kato; Yutaro Kumagai; Himanshu Kumar; Taro Kawai; Osamu Takeuchi; Shizuo Akira
Lymphocytoid choriomeningitis virus activates plasmacytoid dendritic cells and induces a cytotoxic T-cell response via MyD88.
Journal of virology 2008;82(1):196-206.
2007: Osamu Takeuchi; Shizuo Akira
Recognition of viruses by innate immunity.
Immunological reviews 2007;220():214-24.
2007: Masahiro Yamamoto; Satoshi Uematsu; Toru Okamoto; Yoshiharu Matsuura; Shintaro Sato; Himanshu Kumar; Takashi Satoh; Tatsuya Saitoh; Kiyoshi Takeda; Ken J Ishii; Osamu Takeuchi; Taro Kawai; Shizuo Akira
Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
The Journal of experimental medicine 2007;204(9):2233-9.
2007: Takayuki Abe; Yuuki Kaname; Itsuki Hamamoto; Yoshimi Tsuda; Xiaoyu Wen; Shuhei Taguwa; Kohji Moriishi; Osamu Takeuchi; Taro Kawai; Tatsuya Kanto; Norio Hayashi; Shizuo Akira; Yoshiharu Matsuura
Hepatitis C virus nonstructural protein 5A modulates the toll-like receptor-MyD88-dependent signaling pathway in macrophage cell lines.
Journal of virology 2007;81(17):8953-66.
2007: Yutaro Kumagai; Osamu Takeuchi; Hiroki Kato; Himanshu Kumar; Kosuke Matsui; Eiichi Morii; Katsuyuki Aozasa; Taro Kawai; Shizuo Akira
Alveolar macrophages are the primary interferon-alpha producer in pulmonary infection with RNA viruses.
Immunity 2007;27(2):240-52.
2007: Osamu Takeuchi; Shizuo Akira
[Pathogen recognition by innate immunity].
Arerugī = [Allergy] 2007;56(6):558-62.
2007: Tatsukata Kawagoe; Shintaro Sato; Andreas Jung; Masahiro Yamamoto; Kosuke Matsui; Hiroki Kato; Satoshi Uematsu; Osamu Takeuchi; Shizuo Akira
Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling.
The Journal of experimental medicine 2007;204(5):1013-24.
2007: Osamu Takeuchi; Shizuo Akira
Signaling pathways activated by microorganisms.
Current opinion in cell biology 2007;19(2):185-91.
2007: Cevayir Coban; Ken J Ishii; Satoshi Uematsu; Nobuko Arisue; Shintaro Sato; Masahiro Yamamoto; Taro Kawai; Osamu Takeuchi; Hajime Hisaeda; Toshihiro Horii; Shizuo Akira
Pathological role of Toll-like receptor signaling in cerebral malaria.
International immunology 2007;19(1):67-79.
2006: Masahiro Yamamoto; Shintaro Sato; Tatsuya Saitoh; Hiroaki Sakurai; Satoshi Uematsu; Taro Kawai; Ken J Ishii; Osamu Takeuchi; Shizuo Akira
Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(11):7520-4.
2006: Rabindra N Bhattacharjee; Kwon-Sam Park; Yutaro Kumagai; Kazuhisa Okada; Masahiro Yamamoto; Satoshi Uematsu; Kosuke Matsui; Himanshu Kumar; Taro Kawai; Tetsuya Iida; Takeshi Honda; Osamu Takeuchi; Shizuo Akira
VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.
The Journal of biological chemistry 2006;281(48):36897-904.
2006: Kosuke Matsui; Yutaro Kumagai; Hiroki Kato; Shintaro Sato; Tatsukata Kawagoe; Satoshi Uematsu; Osamu Takeuchi; Shizuo Akira
Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.
Journal of immunology (Baltimore, Md. : 1950) 2006;177(9):5785-9.
2006: Shintaro Sato; Hideki Sanjo; Tohru Tsujimura; Jun Ninomiya-Tsuji; Masahiro Yamamoto; Taro Kawai; Osamu Takeuchi; Shizuo Akira
TAK1 is indispensable for development of T cells and prevention of colitis by the generation of regulatory T cells.
International immunology 2006;18(10):1405-11.
2006: Masahiro Yamamoto; Toru Okamoto; Kiyoshi Takeda; Shintaro Sato; Hideki Sanjo; Satoshi Uematsu; Tatsuya Saitoh; Naoki Yamamoto; Hiroaki Sakurai; Ken J Ishii; Shoji Yamaoka; Taro Kawai; Yoshiharu Matsuura; Osamu Takeuchi; Shizuo Akira
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
Nature immunology 2006;7(9):962-70.
2006: Satoshi Uematsu; Myoung Ho Jang; Nicolas Chevrier; Zijin Guo; Yutaro Kumagai; Masahiro Yamamoto; Hiroki Kato; Nagako Sougawa; Hidenori Matsui; Hirotaka Kuwata; Hiroaki Hemmi; Cevayir Coban; Taro Kawai; Ken J Ishii; Osamu Takeuchi; Masayuki Miyasaka; Kiyoshi Takeda; Shizuo Akira
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.
Nature immunology 2006;7(8):868-74.
2006: Himanshu Kumar; Taro Kawai; Hiroki Kato; Shintaro Sato; Ken Takahashi; Cevayir Coban; Masahiro Yamamoto; Satoshi Uematsu; Ken J Ishii; Osamu Takeuchi; Shizuo Akira
Essential role of IPS-1 in innate immune responses against RNA viruses.
The Journal of experimental medicine 2006;203(7):1795-803.
2006: Hiroki Kato; Osamu Takeuchi; Shizuo Akira
[Cell type specific involvement of RIG-I in antiviral responses].
Nihon rinsho. Japanese journal of clinical medicine 2006;64(7):1244-7.
2006: Hiroki Kato; Osamu Takeuchi; Shintaro Sato; Mitsutoshi Yoneyama; Masahiro Yamamoto; Kosuke Matsui; Satoshi Uematsu; Andreas Jung; Taro Kawai; Ken J Ishii; Osamu Yamaguchi; Kinya Otsu; Tohru Tsujimura; Chang-Sung Koh; Caetano Reis e Sousa; Yoshiharu Matsuura; Takashi Fujita; Shizuo Akira
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Nature 2006;441(7089):101-5.
2006: Shizuo Akira; Satoshi Uematsu; Osamu Takeuchi
Pathogen recognition and innate immunity.
Cell 2006;124(4):783-801.
2006: Ken J Ishii; Cevayir Coban; Hiroki Kato; Ken Takahashi; Yuichi Torii; Fumihiko Takeshita; Holger Ludwig; Gerd Sutter; Koichi Suzuki; Hiroaki Hemmi; Shintaro Sato; Masahiro Yamamoto; Satoshi Uematsu; Taro Kawai; Osamu Takeuchi; Shizuo Akira
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
Nature immunology 2006;7(1):40-8.
2005: Rabindra N Bhattacharjee; Kwon-Sam Park; Satoshi Uematsu; Kazuhisa Okada; Katsuaki Hoshino; Kiyoshi Takeda; Osamu Takeuchi; Shizuo Akira; Tetsuya Iida; Takeshi Honda
Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest.
FEBS letters 2005;579(29):6604-10.
2005: Akihiro Kimura; Tetsuji Naka; Tatsushi Muta; Osamu Takeuchi; Shizuo Akira; Ichiro Kawase; Tadamitsu Kishimoto
Suppressor of cytokine signaling-1 selectively inhibits LPS-induced IL-6 production by regulating JAK-STAT.
Proceedings of the National Academy of Sciences of the United States of America 2005;102(47):17089-94.
2005: Shintaro Sato; Hideki Sanjo; Kiyoshi Takeda; Jun Ninomiya-Tsuji; Masahiro Yamamoto; Taro Kawai; Kunihiro Matsumoto; Osamu Takeuchi; Shizuo Akira
Essential function for the kinase TAK1 in innate and adaptive immune responses.
Nature immunology 2005;6(11):1087-95.
2005: Taro Kawai; Ken Takahashi; Shintaro Sato; Cevayir Coban; Himanshu Kumar; Hiroki Kato; Ken J Ishii; Osamu Takeuchi; Shizuo Akira
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction.
Nature immunology 2005;6(10):981-8.
2005: Rabindra N Bhattacharjee; Kwon-Sam Park; Kazuhisa Okada; Yutaro Kumagai; Satoshi Uematsu; Osamu Takeuchi; Shizuo Akira; Tetsuya Iida; Takeshi Honda
Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus.
Biochemical and biophysical research communications 2005;335(2):328-34.
2005: Hiroki Kato; Shintaro Sato; Mitsutoshi Yoneyama; Masahiro Yamamoto; Satoshi Uematsu; Kosuke Matsui; Tohru Tsujimura; Kiyoshi Takeda; Takashi Fujita; Osamu Takeuchi; Shizuo Akira
Cell type-specific involvement of RIG-I in antiviral response.
Immunity 2005;23(1):19-28.
2005: Satoshi Uematsu; Shintaro Sato; Masahiro Yamamoto; Tomonori Hirotani; Hiroki Kato; Fumihiko Takeshita; Michiyuki Matsuda; Cevayir Coban; Ken J Ishii; Taro Kawai; Osamu Takeuchi; Shizuo Akira
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.
The Journal of experimental medicine 2005;201(6):915-23.
2005: Tomonori Hirotani; Masahiro Yamamoto; Yutaro Kumagai; Satoshi Uematsu; Ichiro Kawase; Osamu Takeuchi; Shizuo Akira
Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta.
Biochemical and biophysical research communications 2005;328(2):383-92.
2005: Cevayir Coban; Ken J Ishii; Taro Kawai; Hiroaki Hemmi; Shintaro Sato; Satoshi Uematsu; Masahiro Yamamoto; Osamu Takeuchi; Sawako Itagaki; Nirbhay Kumar; Toshihiro Horii; Shizuo Akira
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin.
The Journal of experimental medicine 2005;201(1):19-25.
2004: Osamu Takeuchi; Shizuo Akira
[Roles of Toll-like receptor in host defense and the mechanism of its signal transduction].
Nihon saikingaku zasshi. Japanese journal of bacteriology 2004;59(4):523-9.
2004: Taro Kawai; Shintaro Sato; Ken J Ishii; Cevayir Coban; Hiroaki Hemmi; Masahiro Yamamoto; Kenta Terai; Michiyuki Matsuda; Jun-ichiro Inoue; Satoshi Uematsu; Osamu Takeuchi; Shizuo Akira
Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6.
Nature immunology 2004;5(10):1061-8.
2004: Masahiro Yamamoto; Soh Yamazaki; Satoshi Uematsu; Shintaro Sato; Hiroaki Hemmi; Katsuaki Hoshino; Tsuneyasu Kaisho; Hirotaka Kuwata; Osamu Takeuchi; Koichiro Takeshige; Tatsuya Saitoh; Shoji Yamaoka; Naoki Yamamoto; Shunsuke Yamamoto; Tatsushi Muta; Kiyoshi Takeda; Shizuo Akira
Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta.
Nature 2004;430(6996):218-22.
2004: Hiroaki Hemmi; Osamu Takeuchi; Shintaro Sato; Masahiro Yamamoto; Tsuneyasu Kaisho; Hideki Sanjo; Taro Kawai; Katsuaki Hoshino; Kiyoshi Takeda; Shizuo Akira
The roles of two IkappaB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.
The Journal of experimental medicine 2004;199(12):1641-50.
2004: Osamu Takeuchi; Hiroaki Hemmi; Shizuo Akira
Interferon response induced by Toll-like receptor signaling.
Journal of endotoxin research 2004;10(4):252-6.
2003: Masahiro Yamamoto; Shintaro Sato; Hiroaki Hemmi; Satoshi Uematsu; Katsuaki Hoshino; Tsuneyasu Kaisho; Osamu Takeuchi; Kiyoshi Takeda; Shizuo Akira
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway.
Nature immunology 2003;4(11):1144-50.
2003: Masahiro Yamamoto; Shintaro Sato; Hiroaki Hemmi; Katsuaki Hoshino; Tsuneyasu Kaisho; Hideki Sanjo; Osamu Takeuchi; Masanaka Sugiyama; Masaru Okabe; Kiyoshi Takeda; Shizuo Akira
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
Science (New York, N.Y.) 2003;301(5633):640-3.
2002: Masahiro Yamamoto; Shintaro Sato; Kiyotoshi Mori; Katsuaki Hoshino; Osamu Takeuchi; Kiyoshi Takeda; Shizuo Akira
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(12):6668-72.
2002: Michael Morr; Osamu Takeuchi; Shizuo Akira; Markus M Simon; Peter F Mühlradt
Differential recognition of structural details of bacterial lipopeptides by toll-like receptors.
European journal of immunology 2002;32(12):3337-47.
2002: Masahiro Yamamoto; Shintaro Sato; Hiroaki Hemmi; Hideki Sanjo; Satoshi Uematsu; Tsuneyasu Kaisho; Katsuaki Hoshino; Osamu Takeuchi; Masaya Kobayashi; Takashi Fujita; Kiyoshi Takeda; Shizuo Akira
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.
Nature 2002;420(6913):324-9.
2002: Reiko Nakagawa; Tetsuji Naka; Hiroko Tsutsui; Minoru Fujimoto; Akihiro Kimura; Tatsuo Abe; Ekihiro Seki; Shintaro Sato; Osamu Takeuchi; Kiyoshi Takeda; Shizuo Akira; Koichi Yamanishi; Ichirou Kawase; Kenji Nakanishi; Tadamitsu Kishimoto
SOCS-1 participates in negative regulation of LPS responses.
Immunity 2002;17(5):677-87.
2002: Katsuaki Hoshino; Tsuneyasu Kaisho; Tomio Iwabe; Osamu Takeuchi; Shizuo Akira
Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation.
International immunology 2002;14(10):1225-31.
2002: Ekihiro Seki; Hiroko Tsutsui; Naotoshi Tsuji; Nobuki Hayashi; Keishi Adachi; Hiroki Nakano; Shizue Futatsugi-Yumikura; Osamu Takeuchi; Katsuaki Hoshino; Shizuo Akira; Jiro Fujimoto; Kenji Nakanishi
Critical roles of myeloid differentiation factor 88-dependent proinflammatory cytokine release in early phase clearance of Listeria monocytogenes in mice.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(7):3863-8.
2002: Osamu Takeuchi; Shizuo Akira
Genetic approaches to the study of Toll-like receptor function.
Microbes and infection / Institut Pasteur 2002;4(9):887-95.
2002: Shintaro Sato; Osamu Takeuchi; Takashi Fujita; Hideyuki Tomizawa; Kiyoshi Takeda; Shizuo Akira
A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways.
International immunology 2002;14(7):783-91.
2002: Tsuneyasu Kaisho; Katsuaki Hoshino; Tomio Iwabe; Osamu Takeuchi; Teruhito Yasui; Shizuo Akira
Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation.
International immunology 2002;14(7):695-700.
2002: Osamu Takeuchi; Shintaro Sato; Takao Horiuchi; Katsuaki Hoshino; Kiyoshi Takeda; Zhongyun Dong; Robert L Modlin; Shizuo Akira
Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.
Journal of immunology (Baltimore, Md. : 1950) 2002;169(1):10-4.
2002: Hiroaki Hemmi; Tsuneyasu Kaisho; Osamu Takeuchi; Shintaro Sato; Hideki Sanjo; Katsuaki Hoshino; Takao Horiuchi; Hideyuki Tomizawa; Kiyoshi Takeda; Shizuo Akira
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway.
Nature immunology 2002;3(2):196-200.
2002: Kiyoshi Takeda; Osamu Takeuchi; Shizuo Akira
Recognition of lipopeptides by Toll-like receptors.
Journal of endotoxin research 2002;8(6):459-63.
2002: Osamu Takeuchi; Shizuo Akira
MyD88 as a bottle neck in Toll/IL-1 signaling.
Current topics in microbiology and immunology 2002;270():155-67.
2001: K Adachi; Hiroko Tsutsui; S Kashiwamura; Ekihiro Seki; Hiroki Nakano; Osamu Takeuchi; Kazuyoshi Takeda; Ko Okumura; Luc Van Kaer; H Okamura; S Akira; Kenji Nakanishi
Plasmodium berghei infection in mice induces liver injury by an IL-12- and toll-like receptor/myeloid differentiation factor 88-dependent mechanism.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5928-34.
2001: Taro Kawai; Osamu Takeuchi; Takashi Fujita; Jun-ichiro Inoue; Peter F Mühlradt; Shintaro Sato; Katsuaki Hoshino; Shizuo Akira
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes.
Journal of immunology (Baltimore, Md. : 1950) 2001;167(10):5887-94.
2001: Osamu Takeuchi; Taro Kawai; Peter F Mühlradt; Michael Morr; J D Radolf; A Zychlinsky; Kiyoshi Takeda; Shizuo Akira
Discrimination of bacterial lipoproteins by Toll-like receptor 6.
International immunology 2001;13(7):933-40.
2001: Tsuneyasu Kaisho; Osamu Takeuchi; Taro Kawai; Katsuaki Hoshino; Shizuo Akira
Endotoxin-induced maturation of MyD88-deficient dendritic cells.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(9):5688-94.
2001: Osamu Takeuchi; Shizuo Akira
Toll-like receptors; their physiological role and signal transduction system.
International immunopharmacology 2001;1(4):625-35.
2001: Ekihiro Seki; H Tsutsui; H Nakano; Naotoshi Tsuji; K Hoshino; O Adachi; K Adachi; S Futatsugi; Keisuke Kuida; Osamu Takeuchi; H Okamura; J Fujimoto; S Akira; K Nakanishi
Lipopolysaccharide-induced IL-18 secretion from murine Kupffer cells independently of myeloid differentiation factor 88 that is critically involved in induction of production of IL-12 and IL-1beta.
Journal of immunology (Baltimore, Md. : 1950) 2001;166(4):2651-7.
2000: Shintaro Sato; F Nomura; Taro Kawai; Osamu Takeuchi; Peter F Mühlradt; Kiyoshi Takeda; Shizuo Akira
Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(12):7096-101.
2000: Hiroaki Hemmi; Osamu Takeuchi; Taro Kawai; Tsuneyasu Kaisho; Shintaro Sato; Hideki Sanjo; Makoto Matsumoto; Katsuaki Hoshino; H Wagner; Kiyoshi Takeda; Shizuo Akira
A Toll-like receptor recognizes bacterial DNA.
Nature 2000;408(6813):740-5.
2000: Osamu Takeuchi; Katsuaki Hoshino; Shizuo Akira
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection.
Journal of immunology (Baltimore, Md. : 1950) 2000;165(10):5392-6.
2000: Masahito Hashimoto; Y Imamura; T Morichika; K Arimoto; Osamu Takeuchi; Kiyoshi Takeda; Shizuo Akira; K Aoyama; Takahiko Tamura; S Kotani; Yasuo Suda; Shoichi Kusumoto
Cytokine-inducing macromolecular glycolipids from Enterococcus hirae: improved method for separation and analysis of its effects on cellular activation.
Biochemical and biophysical research communications 2000;273(1):164-9.
2000: Osamu Takeuchi; Andreas Kaufmann; K Grote; Taro Kawai; Katsuaki Hoshino; Michael Morr; Peter F Mühlradt; Shizuo Akira
Cutting edge: preferentially the R-stereoisomer of the mycoplasmal lipopeptide macrophage-activating lipopeptide-2 activates immune cells through a toll-like receptor 2- and MyD88-dependent signaling pathway.
Journal of immunology (Baltimore, Md. : 1950) 2000;164(2):554-7.
2000: Osamu Takeuchi; Kiyoshi Takeda; Katsuaki Hoshino; O Adachi; Tomohiko Ogawa; Shizuo Akira
Cellular responses to bacterial cell wall components are mediated through MyD88-dependent signaling cascades.
International immunology 2000;12(1):113-7.
1999: Osamu Takeuchi; Katsuaki Hoshino; Taro Kawai; Hideki Sanjo; H Takada; Tomohiko Ogawa; Kiyoshi Takeda; Shizuo Akira
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Immunity 1999;11(4):443-51.