Masaharu Takigawa

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Kawata Kazumi; Kubota Satoshi; Eguchi Takanori; Moritani Norifumi H; Shimo Tsuyoshi; Kondo Seiji; Nishida Takashi; Minagi Shogo; Takigawa Masaharu
Role of the low-density lipoprotein receptor-related protein-1 in regulation of chondrocyte differentiation.
Aoyama Eriko; Hattori Takako; Hoshijima Mitsuhiro; Araki Daisuke; Nishida Takashi; Kubota Satoshi; Takigawa Masaharu
N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan.
Ohgawara Toshihiro; Kubota Satoshi; Kawaki Harumi; Kondo Seiji; Eguchi Takanori; Kurio Naito; Aoyama Eriko; Sasaki Akira; Takigawa Masaharu
Regulation of chondrocytic phenotype by micro RNA 18a: involvement of Ccn2/Ctgf as a major target gene.

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2010: Kawata Kazumi; Kubota Satoshi; Eguchi Takanori; Moritani Norifumi H; Shimo Tsuyoshi; Kondo Seiji; Nishida Takashi; Minagi Shogo; Takigawa Masaharu
Role of the low-density lipoprotein receptor-related protein-1 in regulation of chondrocyte differentiation.
Journal of cellular physiology 2010;222(1):138-48.
2009: Aoyama Eriko; Hattori Takako; Hoshijima Mitsuhiro; Araki Daisuke; Nishida Takashi; Kubota Satoshi; Takigawa Masaharu
N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan.
The Biochemical journal 2009;420(3):413-20.
2009: Ohgawara Toshihiro; Kubota Satoshi; Kawaki Harumi; Kondo Seiji; Eguchi Takanori; Kurio Naito; Aoyama Eriko; Sasaki Akira; Takigawa Masaharu
Regulation of chondrocytic phenotype by micro RNA 18a: involvement of Ccn2/Ctgf as a major target gene.
FEBS letters 2009;583(6):1006-10.
2009: Maeda Azusa; Nishida Takashi; Aoyama Eriko; Kubota Satoshi; Lyons Karen M; Kuboki Takuo; Takigawa Masaharu
CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes.
Journal of biochemistry 2009;145(2):207-16.
2008: Mukudai Yoshiki; Kubota Satoshi; Kawaki Harumi; Kondo Seiji; Eguchi Takanori; Sumiyoshi Kumi; Ohgawara Toshihiro; Shimo Tsuyoshi; Takigawa Masaharu
Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation.
Molecular and cellular biology 2008;28(19):6134-47.
2008: Vincourt Jean-Baptiste; Vignaud Jean-Michel; Lionneton Frédéric; Sirveaux François; Kawaki Harumi; Marchal Sophie; Lomazzi Sandra; Plénat François; Guillemin François; Netter Patrick; Takigawa Masaharu; Mainard Didier; Magdalou Jacques
Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling.
Arthritis and rheumatism 2008;58(9):2798-808.
2008: Kuroda Chisa; Kubota Satoshi; Kawata Kazumi; Aoyama Eriko; Sumiyoshi Kumi; Oka Morihiko; Inoue Miho; Minagi Shogo; Takigawa Masaharu
Distribution, gene expression, and functional role of EphA4 during ossification.
Biochemical and biophysical research communications 2008;374(1):22-7.
2008: Shimo Tsuyoshi; Kubota Satoshi; Goda Takeshi; Yoshihama Yasuto; Kurio Naito; Nishida Takashi; Ng Poh-Sing; Endo Koki; Takigawa Masaharu; Sasakii Akira
Clinical significance and pathogenic function of connective tissue growth factor (CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma.
Anticancer research 2008;28(4C):2343-8.
2008: Motoki Takahiro; Sugiura Yoshihiro; Matsumoto Yohsuke; Tsuji Tomoe; Kubota Satoshi; Takigawa Masaharu; Gohda Eiichi
Induction of hepatocyte growth factor expression by maleic acid in human fibroblasts through MAPK activation.
Journal of cellular biochemistry 2008;104(4):1465-76.
2008: Fujisawa T; Hattori T; Ono M; Uehara J; Kubota S; Kuboki T; Takigawa M
CCN family 2/connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(7):787-95.
2008: Kikuchi Takeshi; Kubota Satoshi; Asaumi Koji; Kawaki Harumi; Nishida Takashi; Kawata Kazumi; Mitani Shigeru; Tabata Yasuhiko; Ozaki Toshifumi; Takigawa Masaharu
Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel.
Tissue engineering. Part A 2008;14(6):1089-98.
2008: Hattori Takako; Coustry Francoise; Stephens Shelley; Eberspaecher Heidi; Takigawa Masaharu; Yasuda Hideyo; de Crombrugghe Benoit
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5.
Nucleic acids research 2008;36(9):3011-24.
2008: Doi Hideyuki; Nishida Keiichiro; Yorimitsu Masanori; Komiyama Takamitsu; Kadota Yasutaka; Tetsunaga Tomonori; Yoshida Aki; Kubota Satoshi; Takigawa Masaharu; Ozaki Toshifumi
Interleukin-4 downregulates the cyclic tensile stress-induced matrix metalloproteinases-13 and cathepsin B expression by rat normal chondrocytes.
Acta medica Okayama 2008;62(2):119-26.
2008: Koitabashi Norimichi; Arai Masashi; Niwano Kazuo; Watanabe Atai; Endoh Michiko; Suguta Masahiko; Yokoyama Tomoyuki; Tada Hiroshi; Toyama Takuji; Adachi Hitoshi; Naito Shigeto; Oshima Shigeru; Nishida Takashi; Kubota Satoshi; Takigawa Masaharu; Kurabayashi Masahiko
Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2008;10(4):373-9.
2008: Heino Terhi J; Chagin Andrei S; Takigawa Masaharu; Sävendahl Lars
Effects of alendronate and pamidronate on cultured rat metatarsal bones: failure to prevent dexamethasone-induced growth retardation.
Bone 2008;42(4):702-9.
2008: Eguchi Takanori; Kubota Satoshi; Kawata Kazumi; Mukudai Yoshiki; Uehara Junji; Ohgawara Toshihiro; Ibaragi Soichiro; Sasaki Akira; Kuboki Takuo; Takigawa Masaharu
Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene.
Molecular and cellular biology 2008;28(7):2391-413.
2008: Kawaki Harumi; Kubota Satoshi; Suzuki Akiko; Yamada Tomohiro; Matsumura Tatsushi; Mandai Toshiko; Yao Mayumi; Maeda Takeyasu; Lyons Karen M; Takigawa Masaharu
Functional requirement of CCN2 for intramembranous bone formation in embryonic mice.
Biochemical and biophysical research communications 2008;366(2):450-6.
2008: Nishida Takashi; Maeda Azusa; Kubota Satoshi; Takigawa Masaharu
Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit costal chondrocytes and meniscus tissue cells.
Biorheology 2008;45(3-4):289-99.
2008: Ono Mitsuaki; Kubota Satoshi; Fujisawa Takuo; Sonoyama Wataru; Kawaki Harumi; Akiyama Kentaro; Shimono Kengo; Oshima Masamitsu; Nishida Takashi; Yoshida Yasuhiro; Suzuki Kazuomi; Takigawa Masaharu; Kuboki Takuo
Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2.
Cell transplantation 2008;17(1-2):231-40.
2007: Oka Morihiko; Kubota Satoshi; Kondo Seiji; Eguchi Takanori; Kuroda Chisa; Kawata Kazumi; Minagi Shogo; Takigawa Masaharu
Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(12):1245-55.
2007: Kubota S; Yeger H; Perbal B; Takigawa M
Report on the fourth international workshop on the CCN family of genes.
Journal of cell communication and signaling 2007;1(1):59-65.
2007: Nishida Takashi; Kawaki Harumi; Baxter Ruth M; Deyoung R Andrea; Takigawa Masaharu; Lyons Karen M
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes.
Journal of cell communication and signaling 2007;1(1):45-58.
2007: Ono Mitsuaki; Kubota Satoshi; Fujisawa Takuo; Sonoyama Wataru; Kawaki Harumi; Akiyama Kentaro; Oshima Masamitsu; Nishida Takashi; Yoshida Yasuhiro; Suzuki Kazuomi; Takigawa Masaharu; Kuboki Takuo
Promotion of attachment of human bone marrow stromal cells by CCN2.
Biochemical and biophysical research communications 2007;357(1):20-5.
2007: Yanagita Takeshi; Kubota Satoshi; Kawaki Harumi; Kawata Kazumi; Kondo Seiji; Takano-Yamamoto Teruko; Tanaka Shinji; Takigawa Masaharu
Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes.
The FEBS journal 2007;274(7):1655-65.
2007: Eguchi Takanori; Kubota Satoshi; Kawata Kazumi; Mukudai Yoshiki; Ohgawara Toshihiro; Miyazono Kohei; Nakao Kyouji; Kondo Seiji; Takigawa Masaharu
Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines.
Biochimie 2007;89(3):278-88.
2007: Kubota Satoshi; Takigawa Masaharu
Role of CCN2/CTGF/Hcs24 in bone growth.
International review of cytology 2007;257():1-41.
2007: Kubota Satoshi; Takigawa Masaharu
CCN family proteins and angiogenesis: from embryo to adulthood.
Angiogenesis 2007;10(1):1-11.
2006: Kubota S; Kawaki H; Kondo S; Yosimichi G; Minato M; Nishida T; Hanagata H; Miyauchi A; Takigawa M
Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in culture.
Biochimie 2006;88(12):1973-81.
2006: Aiga Ayako; Asaumi Koji; Lee You-Jin; Kadota Hiroaki; Mitani Shigeru; Ozaki Toshifumi; Takigawa Masaharu
Expression of neurotrophins and their receptors tropomyosin-related kinases (Trk) under tension-stress during distraction osteogenesis.
Acta medica Okayama 2006;60(5):267-77.
2006: Kawata Kazumi; Eguchi Takanori; Kubota Satoshi; Kawaki Harumi; Oka Morihiko; Minagi Shogo; Takigawa Masaharu
Possible role of LRP1, a CCN2 receptor, in chondrocytes.
Biochemical and biophysical research communications 2006;345(2):552-9.
2006: Yosimichi Gen; Kubota Satoshi; Nishida Takashi; Kondo Seiji; Yanagita Takeshi; Nakao Kyouji; Takano-Yamamoto Teruko; Takigawa Masaharu
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes.
Bone 2006;38(6):853-63.
2006: Hoshijima Mitsuhiro; Hattori Takako; Inoue Miho; Araki Daisuke; Hanagata Hiroshi; Miyauchi Akira; Takigawa Masaharu
CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1.
FEBS letters 2006;580(5):1376-82.
2006: Kondo S; Kubota S; Mukudai Y; Moritani N; Nishida T; Matsushita H; Matsumoto S; Sugahara T; Takigawa M
Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells.
Oncogene 2006;25(7):1099-110.
2006: Kondo Seiji; Tanaka Noriko; Kubota Satoshi; Mukudai Yoshiki; Yosimichi Gen; Sugahara Toshio; Takigawa Masaharu
Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor in human endothelial cells.
Molecular cancer therapeutics 2006;5(1):129-37.
2005: Asano Masahiro; Kubota Satoshi; Nakanishi Tohru; Nishida Takashi; Yamaai Tomoichiro; Yosimichi Gen; Ohyama Kazumi; Sugimoto Tomosada; Murayama Yoji; Takigawa Masaharu
Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.
Cell communication and signaling : CCS 2005;3():11.
2005: Kubota Satoshi; Mukudai Yoshiki; Moritani Norifumi H; Nakao Kyouji; Kawata Kazumi; Takigawa Masaharu
Translational repression by the cis-acting element of structure-anchored repression (CAESAR) of human ctgf/ccn2 mRNA.
FEBS letters 2005;579(17):3751-8.
2005: Nakao Kyouji; Kubota Satoshi; Doi Hideyuki; Eguchi Takanori; Oka Morihiko; Fujisawa Takuo; Nishida Takashi; Takigawa Masaharu
Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes: possible regenerative roles in articular cartilage metabolism.
Bone 2005;36(5):884-92.
2005: Mukudai Yoshiki; Kubota Satoshi; Eguchi Takanori; Kondo Seiji; Nakao Kyouji; Takigawa Masaharu
Regulation of chicken ccn2 gene by interaction between RNA cis-element and putative trans-factor during differentiation of chondrocytes.
The Journal of biological chemistry 2005;280(5):3166-77.
2005: Hattori Takako; von der Mark Klaus; Kawaki Harumi; Yutani Yasutaka; Kubota Satoshi; Nakanishi Tohru; Eberspaecher Heidi; de Crombrugghe Benoit; Takigawa Masaharu
Downregulation of rheumatoid arthritis-related antigen RA-A47 (HSP47/colligin-2) in chondrocytic cell lines induces apoptosis and cell-surface expression of RA-A47 in association with CD9.
Journal of cellular physiology 2005;202(1):191-204.
2005: Yamaai Tomoichiro; Nakanishi Tohru; Asano Masahiro; Nawachi Kumiko; Yoshimichi Gen; Ohyama Kazumi; Komori Toshifumi; Sugimoto Tomosada; Takigawa Masaharu
Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development.
Journal of bone and mineral metabolism 2005;23(4):280-8.
2004: Kubota Satoshi; Kawata Kazumi; Yanagita Takeshi; Doi Hideyuki; Kitoh Takashi; Takigawa Masaharu
Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets.
Journal of biochemistry 2004;136(3):279-82.
2004: Nishida Takashi; Kubota Satoshi; Kojima Shunji; Kuboki Takuo; Nakao Kyouji; Kushibiki Toshihiro; Tabata Yasuhiko; Takigawa Masaharu
Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(8):1308-19.
2004: Minato Masanao; Kubota Satoshi; Kawaki Harumi; Nishida Takashi; Miyauchi Akira; Hanagata Hiroshi; Nakanishi Tohru; Takano-Yamamoto Teruko; Takigawa Masaharu
Module-specific antibodies against human connective tissue growth factor: utility for structural and functional analysis of the factor as related to chondrocytes.
Journal of biochemistry 2004;135(3):347-54.
2004: Kadota Hiroaki; Nakanishi Tohru; Asaumi Koji; Yamaai Tomoichiro; Nakata Eiji; Mitani Shigeru; Aoki Kiyoshi; Aiga Ayako; Inoue Hajime; Takigawa Masaharu
Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24/CCN2) during distraction osteogenesis.
Journal of bone and mineral metabolism 2004;22(4):293-302.
2003: Kawaki Harumi; Kubota Satoshi; Minato Masanao; Moritani Norifumi H; Hattori Takako; Hanagata Hiroshi; Kubota Mamoru; Miyauchi Akira; Nakanishi Tohru; Takigawa Masaharu
Novel enzyme-linked immunosorbent assay systems for the quantitative analysis of connective tissue growth factor (CTGF/Hcs24/CCN2): detection of HTLV-I tax-induced CTGF from a human carcinoma cell line.
DNA and cell biology 2003;22(10):641-8.
2003: Kubota Satoshi; Moritani Norifumi H; Kawaki Harumi; Mimura Haruyo; Minato Masanao; Takigawa Masaharu
Transcriptional induction of connective tissue growth factor/hypertrophic chondrocyte-specific 24 gene by dexamethasone in human chondrocytic cells.
Bone 2003;33(4):694-702.
2003: Kanyama Manabu; Kuboki Takuo; Akiyama Kentaro; Nawachi Kumiko; Miyauchi Fabiora M; Yatani Hirofumi; Kubota Satoshi; Nakanishi Tohru; Takigawa Masaharu
Connective tissue growth factor expressed in rat alveolar bone regeneration sites after tooth extraction.
Archives of oral biology 2003;48(10):723-30.
2003: Hattori Takako; Kawaki Harumi; Kubota Satoshi; Yutani Yasutaka; de Crombrugghe Benoit; von der Mark Klaus; Takigawa Masaharu
Downregulation of a rheumatoid arthritis-related antigen (RA-A47) by ra-a47 antisense oligonucleotides induces inflammatory factors in chondrocytes.
Journal of cellular physiology 2003;197(1):94-102.
2003: Fujisawa T; Kuboki T; Kasai T; Sonoyama W; Kojima S; Uehara J; Komori C; Yatani H; Hattori T; Takigawa M
A repetitive, steady mouth opening induced an osteoarthritis-like lesion in the rabbit temporomandibular joint.
Journal of dental research 2003;82(9):731-5.
2003: Nishida Takashi; Kubota Satoshi; Fukunaga Tomohiro; Kondo Seiji; Yosimichi Gen; Nakanishi Tohru; Takano-Yamamoto Teruko; Takigawa Masaharu
CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes.
Journal of cellular physiology 2003;196(2):265-75.
2003: Kuboki Takuo; Kanyama Manabu; Nakanishi Tohru; Akiyama Kentaro; Nawachi Kumiko; Yatani Hirofumi; Yamashita Kazuo; Takano-Yamamoto Teruko; Takigawa Masaharu
Cbfa1/Runx2 gene expression in articular chondrocytes of the mice temporomandibular and knee joints in vivo.
Archives of oral biology 2003;48(7):519-25.
2003: Moritani Norifumi H; Kubota Satoshi; Nishida Takashi; Kawaki Harumi; Kondo Seiji; Sugahara Toshio; Takigawa Masaharu
Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line.
Cancer letters 2003;192(2):205-14.
2003: Takigawa Masaharu; Nakanishi Tohru; Kubota Satoshi; Nishida Takashi
Role of CTGF/HCS24/ecogenin in skeletal growth control.
Journal of cellular physiology 2003;194(3):256-66.
2003: Takigawa Masaharu
CTGF/Hcs24 as a multifunctional growth factor for fibroblasts, chondrocytes and vascular endothelial cells.
Drug news & perspectives 2003;16(1):11-21.
2003: Mukudai Yoshiki; Kubota Satoshi; Takigawa Masaharu
Conserved repressive regulation of connective tissue growth factor/hypertrophic chondrocyte-specific gene 24 (ctgf/hcs24) enabled by different elements and factors among vertebrate species.
Biological chemistry 2003;384(1):1-9.
2003: Moritani Norifumi H; Kubota Satoshi; Eguchi Takanori; Fukunaga Tomohiro; Yamashiro Takashi; Takano-Yamamoto Teruko; Tahara Hideki; Ohyama Kazumi; Sugahara Toshio; Takigawa Masaharu
Interaction of AP-1 and the ctgf gene: a possible driver of chondrocyte hypertrophy in growth cartilage.
Journal of bone and mineral metabolism 2003;21(4):205-10.
2002: Yosimichi Gen; Kubota Satoshi; Hattori Takako; Nishida Takashi; Nawachi Kumiko; Nakanishi Tohru; Kamada Masafumi; Takano-Yamamoto Teruko; Takigawa Masaharu
CTGF/Hcs24 interacts with the cytoskeletal protein actin in chondrocytes.
Biochemical and biophysical research communications 2002;299(5):755-61.
2002: Nakata E; Nakanishi T; Kawai A; Asaumi K; Yamaai T; Asano M; Nishida T; Mitani S; Inoue H; Takigawa M
Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture healing.
Bone 2002;31(4):441-7.
2002: Nawachi Kumiko; Inoue Miho; Kubota Satoshi; Nishida Takashi; Yosimichi Gen; Nakanishi Tohru; Kanyama Manabu; Kuboki Takuo; Yatani Hirofumi; Yamaai Tomoichiro; Takigawa Masaharu
Tyrosine kinase-type receptor ErbB4 in chondrocytes: interaction with connective tissue growth factor and distribution in cartilage.
FEBS letters 2002;528(1-3):109-13.
2002: Eguchi Takanori; Kubota Satoshi; Kondo Seiji; Kuboki Takuo; Yatani Hirofumi; Takigawa Masaharu
A novel cis-element that enhances connective tissue growth factor gene expression in chondrocytic cells.
Biochemical and biophysical research communications 2002;295(2):445-51.
2002: Nishida Takashi; Kubota Satoshi; Nakanishi Tohru; Kuboki Takuo; Yosimichi Gen; Kondo Seiji; Takigawa Masaharu
CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes.
Journal of cellular physiology 2002;192(1):55-63.
2002: Kondo Seiji; Kubota Satoshi; Shimo Tsuyoshi; Nishida Takashi; Yosimichi Gen; Eguchi Takanori; Sugahara Toshio; Takigawa Masaharu
Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases.
Carcinogenesis 2002;23(5):769-76.
2001: Yosimichi G; Nakanishi T; Nishida T; Hattori T; Takano-Yamamoto T; Takigawa M
CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK).
European journal of biochemistry / FEBS 2001;268(23):6058-65.
2001: Shimo T; Kubota S; Kondo S; Nakanishi T; Sasaki A; Mese H; Matsumura T; Takigawa M
Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line.
Cancer letters 2001;174(1):57-64.
2001: Kubota S; Mukudai Y; Hattori T; Eguchi T; Kondo S; Takigawa M
Cell-type-specific trans-activation of herpes simplex virus thymidine kinase promoter by the human T-cell leukemia virus type I Tax protein.
DNA and cell biology 2001;20(9):563-8.
2001: Kubota S; Eguchi T; Shimo T; Nishida T; Hattori T; Kondo S; Nakanishi T; Takigawa M
Novel mode of processing and secretion of connective tissue growth factor/ecogenin (CTGF/Hcs24) in chondrocytic HCS-2/8 cells.
Bone 2001;29(2):155-61.
2001: Eguchi T; Kubota S; Kondo S; Shimo T; Hattori T; Nakanishi T; Kuboki T; Yatani H; Takigawa M
Regulatory mechanism of human connective tissue growth factor (CTGF/Hcs24) gene expression in a human chondrocytic cell line, HCS-2/8.
Journal of biochemistry 2001;130(1):79-87.
2001: Nakanishi T; Yamaai T; Asano M; Nawachi K; Suzuki M; Sugimoto T; Takigawa M
Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism.
Biochemical and biophysical research communications 2001;281(3):678-81.
2001: Hattori T; Kubota S; Yutani Y; Fujisawa T; Nakanishi T; Takahashi K; Takigawa M
Change in cellular localization of a rheumatoid arthritis-related antigen (RA-A47) with downregulation upon stimulation by inflammatory cytokines in chondrocytes.
Journal of cellular physiology 2001;186(2):268-281.
2001: Shimo T; Nakanishi T; Nishida T; Asano M; Sasaki A; Kanyama M; Kuboki T; Matsumura T; Takigawa M
Involvement of CTGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesis.
Oncology 2001;61(4):315-22.
2000: Kondo S; Kubota S; Eguchi T; Hattori T; Nakanishi T; Sugahara T; Takigawa M
Characterization of a mouse ctgf 3'-UTR segment that mediates repressive regulation of gene expression.
Biochemical and biophysical research communications 2000;278(1):119-24.
2000: Kubota S; Kondo S; Eguchi T; Hattori T; Nakanishi T; Pomerantz R J; Takigawa M
Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/hcs24) gene: similarities to retroviral RNA-protein interactions.
Oncogene 2000;19(41):4773-86.
2000: Nishida T; Nakanishi T; Asano M; Shimo T; Takigawa M
Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro.
Journal of cellular physiology 2000;184(2):197-206.
2000: Asaumi K; Nakanishi T; Asahara H; Inoue H; Takigawa M
Expression of neurotrophins and their receptors (TRK) during fracture healing.
Bone 2000;26(6):625-33.
2000: Kubota S; Hattori T; Shimo T; Nakanishi T; Takigawa M
Novel intracellular effects of human connective tissue growth factor expressed in Cos-7 cells.
FEBS letters 2000;474(1):58-62.
2000: Nakanishi T; Nishida T; Shimo T; Kobayashi K; Kubo T; Tamatani T; Tezuka K; Takigawa M
Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.
Endocrinology 2000;141(1):264-73.
2000: Kanyama M; Kuboki T; Kojima S; Fujisawa T; Hattori T; Takigawa M; Yamashita A
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids of patients with temporomandibular joint osteoarthritis.
Journal of orofacial pain 2000;14(1):20-30.
2000: Hattori T; Takahash K; Yutani Y; Fujisawa T; Nakanishi T; Takigawa M
Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47.
Journal of bone and mineral metabolism 2000;18(6):328-34.
1999: Kuboki T; Nakanishi T; Kanyama M; Sonoyama W; Fujisawa T; Kobayashi K; Ikeda T; Kubo T; Yamashita A; Takigawa M
Direct adenovirus-mediated gene delivery to the temporomandibular joint in guinea-pigs.
Archives of oral biology 1999;44(9):701-9.
1999: Shimo T; Nakanishi T; Nishida T; Asano M; Kanyama M; Kuboki T; Tamatani T; Tezuka K; Takemura M; Matsumura T; Takigawa M
Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo.
Journal of biochemistry 1999;126(1):137-45.
1999: Kuboki T; Hattori T; Mizushima T; Kanyama M; Fujisawa T; Yamashita A; Takigawa M
Detection of specific antibodies against human cultured chondrosarcoma (HCS-2/8) and osteosarcoma (Saos-2) cells in the serum of patients with osteoarthritis of the temporomandibular joint.
Archives of oral biology 1999;44(5):403-14.
1999: Fujisawa T; Hattori T; Takahashi K; Kuboki T; Yamashita A; Takigawa M
Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1.
Journal of biochemistry 1999;125(5):966-75.
1999: Kubota S; Hattori T; Nakanishi T; Takigawa M
Involvement of cis-acting repressive element(s) in the 3'-untranslated region of human connective tissue growth factor gene.
FEBS letters 1999;450(1-2):84-8.
1998: Tamatani T; Kobayashi H; Tezuka K; Sakamoto S; Suzuki K; Nakanishi T; Takigawa M; Miyano T
Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia.
Biochemical and biophysical research communications 1998;251(3):748-52.
1998: Shimo T; Nakanishi T; Kimura Y; Nishida T; Ishizeki K; Matsumura T; Takigawa M
Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells.
Journal of biochemistry 1998;124(1):130-40.
1998: Nishida T; Nakanishi T; Shimo T; Asano M; Hattori T; Tamatani T; Tezuka K; Takigawa M
Demonstration of receptors specific for connective tissue growth factor on a human chondrocytic cell line (HCS-2/8).
Biochemical and biophysical research communications 1998;247(3):905-9.
1998: Hattori T; Fujisawa T; Sasaki K; Yutani Y; Nakanishi T; Takahashi K; Takigawa M
Isolation and characterization of a rheumatoid arthritis-specific antigen (RA-A47) from a human chondrocytic cell line (HCS-2/8).
Biochemical and biophysical research communications 1998;245(3):679-83.
1998: Sasaki K; Hattori T; Fujisawa T; Takahashi K; Inoue H; Takigawa M
Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes.
Journal of biochemistry 1998;123(3):431-9.
1997: Takigawa M; Okawa T; Pan H; Aoki C; Takahashi K; Zue J; Suzuki F; Kinoshita A
Insulin-like growth factors I and II are autocrine factors in stimulating proteoglycan synthesis, a marker of differentiated chondrocytes, acting through their respective receptors on a clonal human chondrosarcoma-derived chondrocyte cell line, HCS-2/8.
Endocrinology 1997;138(10):4390-400.
1997: Nakanishi T; Kimura Y; Tamura T; Ichikawa H; Yamaai Y; Sugimoto T; Takigawa M
Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA.
Biochemical and biophysical research communications 1997;234(1):206-10.
1996: Tamura T; Nakanishi T; Kimura Y; Hattori T; Sasaki K; Norimatsu H; Takahashi K; Takigawa M
Nitric oxide mediates interleukin-1-induced matrix degradation and basic fibroblast growth factor release in cultured rabbit articular chondrocytes: a possible mechanism of pathological neovascularization in arthritis.
Endocrinology 1996;137(9):3729-37.
1995: Ohba Y; Goto Y; Kimura Y; Suzuki F; Hisa T; Takahashi K; Takigawa M
Purification of an angiogenesis inhibitor from culture medium conditioned by a human chondrosarcoma-derived chondrocytic cell line, HCS-2/8.
Biochimica et biophysica acta 1995;1245(1):1-8.
1994: Nakanishi T; Ohyama K; Aoki C; Kudo A; Hattori T; Takahashi K; Taniguchi S; Takigawa M
Expression of trkC in a mouse osteoblastic cell line and its response to neurotrophin-3.
Biochemical and biophysical research communications 1994;203(2):1268-74.

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