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Masaharu Takigawa

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Reverse Transcriptase Polymerase Chain Reaction

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Takashi Nishida; E Aoyama; Satoshi Kubota; Masaharu Takigawa
Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus.
Tarek Abd El Kader; Eriko Aoyama; Takako Hattori; Danilo Janune; Takuo Kuboki; Satoshi Kubota; Takashi Nishida; Bernard Perbal; Masaharu Takigawa
Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family.
Emilio Satoshi Hara; Takako Hattori; Takayuki Furumatsu; Satoshi Kubota; Takashi Nishida; Yasutaka Oida; Mitsuaki Ono; Toshifumi Ozaki; Wataru Sonoyama; Masaharu Takigawa; Takuo Kuboki
Novel chondrogenic and chondroprotective effects of the natural compound harmine.

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2013: Takashi Nishida; E Aoyama; Satoshi Kubota; Masaharu Takigawa
Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2013;21(5):700-9.
2013: Tarek Abd El Kader; Eriko Aoyama; Takako Hattori; Danilo Janune; Takuo Kuboki; Satoshi Kubota; Takashi Nishida; Bernard Perbal; Masaharu Takigawa
Anti-fibrotic effect of CCN3 accompanied by altered gene expression profile of the CCN family.
Journal of cell communication and signaling 2013;7(1):11-8.
2013: Emilio Satoshi Hara; Takako Hattori; Takayuki Furumatsu; Satoshi Kubota; Takashi Nishida; Yasutaka Oida; Mitsuaki Ono; Toshifumi Ozaki; Wataru Sonoyama; Masaharu Takigawa; Takuo Kuboki
Novel chondrogenic and chondroprotective effects of the natural compound harmine.
Biochimie 2013;95(2):374-81.
2013: Nao Tomita; Takashi Yamashiro; Mayumi Yao; Eriko Aoyama; Takako Hattori; Shinsuke Itoh; Masaharu Takigawa
Cartilage-specific over-expression of CCN family member 2/connective tissue growth factor (CCN2/CTGF) stimulates insulin-like growth factor expression and bone growth.
PloS one 2013;8(3):e59226.
2012: Eriko Aoyama; Satoshi Kubota; Masaharu Takigawa
CCN2/CTGF binds to fibroblast growth factor receptor 2 and modulates its signaling.
FEBS letters 2012;586(24):4270-5.
2012: Tadashi Honjo; Yoshihito Ishihara; Hiroshi Kamioka; Satoshi Kubota; Yasuyo Sugawara; Masaharu Takigawa; Takashi Yamashiro; Teruko Takano-Yamamoto
Promotion of Ccn2 expression and osteoblastic differentiation by actin polymerization, which is induced by laminar fluid flow stress.
Journal of cell communication and signaling 2012;6(4):225-32.
2012: Takayuki Furumatsu; Tomoko Kanazawa; Satoshi Kubota; Yoshiaki Miyake; Masaharu Takigawa; Toshifumi Ozaki
Mechanical stretch increases Smad3-dependent CCN2 expression in inner meniscus cells.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012;30(11):1738-45.
2012: Mitsuhiro Hoshijima; Takashi Nishida; Eriko Aoyama; Takako Hattori; Takashi Yamashiro; Masaharu Takigawa
Roles of heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in expression of the differentiated phenotype of chondrocytes.
The FEBS journal 2012;279(19):3584-97.
2012: Kazumi Kawata; Seiji Kondo; Satoshi Kubota; Norifumi H Moritani; Takashi Nishida; Eriko Aoyama; Takanori Eguchi; Masaharu Takigawa
Role of LRP1 in transport of CCN2 protein in chondrocytes.
Journal of cell science 2012;125(Pt 12):2965-72.
2011: Takashi Nishida; Eriko Aoyama; Danilo Janune; Satoshi Kubota; Azusa Maeda; Masaharu Takigawa
Effect of CCN2 on FGF2-induced proliferation and MMP9 and MMP13 productions by chondrocytes.
Endocrinology 2011;152(11):4232-41.
2011: Harumi Kawaki; Kumiko Kohsaka; Satoshi Kubota; Noureddine Lazar; Takeyasu Maeda; Toshihiro Ohgawara; Bernard Perbal; Akiko Suzuki; Makoto Suzuki; Teruko Takano-Yamamoto; Toshiya Fujii; Kenji Hoshi; Masaharu Takigawa
Differential roles of CCN family proteins during osteoblast differentiation: Involvement of Smad and MAPK signaling pathways.
Bone 2011;49(5):975-89.
2011: Danilo Janune; Harumi Kawaki; Satoshi Kubota; Takashi Nishida; Bernard Perbal; Seiji Iida; Masaharu Takigawa
Novel effects of CCN3 that may direct the differentiation of chondrocytes.
FEBS letters 2011;585(19):3033-40.
2011: Danilo Janune; Satoshi Kubota; Noureddine Lazar; Bernard Perbal; Seiji Iida; Masaharu Takigawa
CCN3-mediated promotion of sulfated proteoglycan synthesis in rat chondrocytes from developing joint heads.
Journal of cell communication and signaling 2011;5(3):167-71.
2011: Satoshi Kubota; Masaharu Takigawa
The role of CCN2 in cartilage and bone development.
Journal of cell communication and signaling 2011;5(3):209-17.
2011: Yoshiaki Miyake; Takayuki Furumatsu; Satoshi Kubota; Kazumi Kawata; Toshifumi Ozaki; Masaharu Takigawa
Mechanical stretch increases CCN2/CTGF expression in anterior cruciate ligament-derived cells.
Biochemical and biophysical research communications 2011;409(2):247-52.
2011: Seiji Kondo; Satoshi Kubota; Yoshiki Mukudai; Takashi Nishida; Yasuto Yoshihama; Tatsuo Shirota; Satoru Shintani; Masaharu Takigawa
Binding of glyceraldehyde-3-phosphate dehydrogenase to the cis-acting element of structure-anchored repression in ccn2 mRNA.
Biochemical and biophysical research communications 2011;405(3):382-7.
2011: Takashi Nishida; Kenji Emura; Satoshi Kubota; Karen M Lyons; Masaharu Takigawa
CCN family 2/connective tissue growth factor (CCN2/CTGF) promotes osteoclastogenesis via induction of and interaction with dendritic cell-specific transmembrane protein (DC-STAMP).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011;26(2):351-63.
2010: Yoshiki Mukudai; Satoshi Kubota; Takanori Eguchi; Kumi Sumiyoshi; Danilo Janune; Seiji Kondo; Satoru Shintani; Masaharu Takigawa
A coding RNA segment that enhances the ribosomal recruitment of chicken ccn1 mRNA.
Journal of cellular biochemistry 2010;111(6):1607-18.
2010: Kumi Sumiyoshi; Satoshi Kubota; Toshihiro Ohgawara; Kazumi Kawata; Takashi Nishida; Tsuyoshi Shimo; Takashi Yamashiro; Masaharu Takigawa
Identification of miR-1 as a micro RNA that supports late-stage differentiation of growth cartilage cells.
Biochemical and biophysical research communications 2010;402(2):286-90.
2010: Harumi Kawaki; Satoshi Kubota; Eriko Aoyama; Naoya Fujita; Hiroshi Hanagata; Akira Miyauchi; Kenta Nakai; Masaharu Takigawa
Design and utility of CCN2 anchor peptide aptamers.
Biochimie 2010;92(8):1010-5.
2010: Emma Lindahl; Ulrika Nyman; Farasat Zaman; Carina Palmberg; Anna Cascante; Jawed Shafqat; Masaharu Takigawa; Lars Sävendahl; Hans Jörnvall; Bertrand Joseph
Proinsulin C-peptide regulates ribosomal RNA expression.
The Journal of biological chemistry 2010;285(5):3462-9.
2010: Kazumi Kawata; Satoshi Kubota; Takanori Eguchi; Norifumi H Moritani; Tsuyoshi Shimo; Seiji Kondo; Takashi Nishida; Shogo Minagi; Masaharu Takigawa
Role of the low-density lipoprotein receptor-related protein-1 in regulation of chondrocyte differentiation.
Journal of cellular physiology 2010;222(1):138-48.
2009: Eriko Aoyama; Takako Hattori; Mitsuhiro Hoshijima; Daisuke Araki; Takashi Nishida; Satoshi Kubota; Masaharu Takigawa
N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan.
The Biochemical journal 2009;420(3):413-20.
2009: Toshihiro Ohgawara; Satoshi Kubota; Harumi Kawaki; Seiji Kondo; Takanori Eguchi; Naito Kurio; Eriko Aoyama; Akira Sasaki; Masaharu Takigawa
Regulation of chondrocytic phenotype by micro RNA 18a: involvement of Ccn2/Ctgf as a major target gene.
FEBS letters 2009;583(6):1006-10.
2009: Azusa Maeda; Takashi Nishida; Eriko Aoyama; Satoshi Kubota; Karen M Lyons; Takuo Kuboki; Masaharu Takigawa
CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes.
Journal of biochemistry 2009;145(2):207-16.
2008: Yoshiki Mukudai; Satoshi Kubota; Harumi Kawaki; Seiji Kondo; Takanori Eguchi; Kumi Sumiyoshi; Toshihiro Ohgawara; Tsuyoshi Shimo; Masaharu Takigawa
Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation.
Molecular and cellular biology 2008;28(19):6134-47.
2008: Chisa Kuroda; Satoshi Kubota; Kazumi Kawata; Eriko Aoyama; Kumi Sumiyoshi; Morihiko Oka; Miho Inoue; Shogo Minagi; Masaharu Takigawa
Distribution, gene expression, and functional role of EphA4 during ossification.
Biochemical and biophysical research communications 2008;374(1):22-7.
2008: Jean-Baptiste Vincourt; Jean-Michel Vignaud; Frédéric Lionneton; François Sirveaux; Harumi Kawaki; Sophie Marchal; Sandra Lomazzi; François Plénat; François Guillemin; Patrick Netter; Masaharu Takigawa; Didier Mainard; Jacques Magdalou
Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling.
Arthritis and rheumatism 2008;58(9):2798-808.
2008: Tsuyoshi Shimo; Satoshi Kubota; Takeshi Goda; Yasuto Yoshihama; Naito Kurio; Takashi Nishida; Poh-Sing Ng; Koki Endo; Masaharu Takigawa; Akira Sasakii
Clinical significance and pathogenic function of connective tissue growth factor (CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma.
Anticancer research 2008;28(4C):2343-8.
2008: Takahiro Motoki; Yoshihiro Sugiura; Yohsuke Matsumoto; Tomoe Tsuji; Satoshi Kubota; Masaharu Takigawa; Eiichi Gohda
Induction of hepatocyte growth factor expression by maleic acid in human fibroblasts through MAPK activation.
Journal of cellular biochemistry 2008;104(4):1465-76.
2008: Takuo Fujisawa; Takako Hattori; M Ono; J Uehara; Satoshi Kubota; Takuo Kuboki; Masaharu Takigawa
CCN family 2/connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(7):787-95.
2008: Takeshi Kikuchi; Satoshi Kubota; Koji Asaumi; Harumi Kawaki; Takashi Nishida; Kazumi Kawata; Shigeru Mitani; Yasuhiko Tabata; Toshifumi Ozaki; Masaharu Takigawa
Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel.
Tissue engineering. Part A 2008;14(6):1089-98.
2008: Takako Hattori; Francoise Coustry; Shelley Stephens; Heidi Eberspaecher; Masaharu Takigawa; Hideyo Yasuda; Benoit de Crombrugghe
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5.
Nucleic acids research 2008;36(9):3011-24.
2008: Hideyuki Doi; Keiichiro Nishida; Masanori Yorimitsu; Takamitsu Komiyama; Yasutaka Kadota; Tomonori Tetsunaga; Aki Yoshida; Satoshi Kubota; Masaharu Takigawa; Toshifumi Ozaki
Interleukin-4 downregulates the cyclic tensile stress-induced matrix metalloproteinases-13 and cathepsin B expression by rat normal chondrocytes.
Acta medica Okayama 2008;62(2):119-26.
2008: Norimichi Koitabashi; Masashi Arai; Kazuo Niwano; Atai Watanabe; Michiko Endoh; Masahiko Suguta; Tomoyuki Yokoyama; Hiroshi Tada; Takuji Toyama; Hitoshi Adachi; Shigeto Naito; Shigeru Oshima; Takashi Nishida; Satoshi Kubota; Masaharu Takigawa; Masahiko Kurabayashi
Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure.
European journal of heart failure 2008;10(4):373-9.
2008: Terhi J Heino; Andrei S Chagin; Masaharu Takigawa; Lars Sävendahl
Effects of alendronate and pamidronate on cultured rat metatarsal bones: failure to prevent dexamethasone-induced growth retardation.
Bone 2008;42(4):702-9.
2008: Takanori Eguchi; Satoshi Kubota; Kazumi Kawata; Yoshiki Mukudai; Junji Uehara; Toshihiro Ohgawara; Soichiro Ibaragi; Akira Sasaki; Takuo Kuboki; Masaharu Takigawa
Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene.
Molecular and cellular biology 2008;28(7):2391-413.
2008: Harumi Kawaki; Satoshi Kubota; Akiko Suzuki; Tomohiro Yamada; Tatsushi Matsumura; Toshiko Mandai; Mayumi Yao; Takeyasu Maeda; Karen M Lyons; Masaharu Takigawa
Functional requirement of CCN2 for intramembranous bone formation in embryonic mice.
Biochemical and biophysical research communications 2008;366(2):450-6.
2008: Takashi Nishida; Azusa Maeda; Satoshi Kubota; Masaharu Takigawa
Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit costal chondrocytes and meniscus tissue cells.
Biorheology 2008;45(3-4):289-99.
2008: Mitsuaki Ono; Satoshi Kubota; Takuo Fujisawa; Wataru Sonoyama; Harumi Kawaki; Kentaro Akiyama; Kengo Shimono; Masamitsu Oshima; Takashi Nishida; Yasuhiro Yoshida; Kazuomi Suzuki; Masaharu Takigawa; Takuo Kuboki
Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2.
Cell transplantation 2008;17(1-2):231-40.
2007: Morihiko Oka; Satoshi Kubota; Seiji Kondo; Takanori Eguchi; Chisa Kuroda; Kazumi Kawata; Shogo Minagi; Masaharu Takigawa
Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(12):1245-55.
2007: S Kubota; H Yeger; B Perbal; Masaharu Takigawa
Report on the fourth international workshop on the CCN family of genes.
Journal of cell communication and signaling 2007;1(1):59-65.
2007: Takashi Nishida; Harumi Kawaki; Ruth M Baxter; R Andrea Deyoung; Masaharu Takigawa; Karen M Lyons
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes.
Journal of cell communication and signaling 2007;1(1):45-58.
2007: Mitsuaki Ono; Satoshi Kubota; Takuo Fujisawa; Wataru Sonoyama; Harumi Kawaki; Kentaro Akiyama; Masamitsu Oshima; Takashi Nishida; Yasuhiro Yoshida; Kazuomi Suzuki; Masaharu Takigawa; Takuo Kuboki
Promotion of attachment of human bone marrow stromal cells by CCN2.
Biochemical and biophysical research communications 2007;357(1):20-5.
2007: Takeshi Yanagita; Satoshi Kubota; Harumi Kawaki; Kazumi Kawata; Seiji Kondo; Teruko Takano-Yamamoto; Shinji Tanaka; Masaharu Takigawa
Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes.
The FEBS journal 2007;274(7):1655-65.
2007: Takanori Eguchi; Satoshi Kubota; Kazumi Kawata; Yoshiki Mukudai; Toshihiro Ohgawara; Kohei Miyazono; Kyouji Nakao; Seiji Kondo; Masaharu Takigawa
Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines.
Biochimie 2007;89(3):278-88.
2007: Satoshi Kubota; Masaharu Takigawa
Role of CCN2/CTGF/Hcs24 in bone growth.
International review of cytology 2007;257():1-41.
2007: Satoshi Kubota; Masaharu Takigawa
CCN family proteins and angiogenesis: from embryo to adulthood.
Angiogenesis 2007;10(1):1-11.
2006: Satoshi Kubota; Harumi Kawaki; Seiji Kondo; Gen Yosimichi; Masanao Minato; Takashi Nishida; Hiroshi Hanagata; Akira Miyauchi; Masaharu Takigawa
Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in culture.
Biochimie 2006;88(12):1973-81.
2006: Ayako Aiga; Koji Asaumi; You-Jin Lee; Hiroaki Kadota; Shigeru Mitani; Toshifumi Ozaki; Masaharu Takigawa
Expression of neurotrophins and their receptors tropomyosin-related kinases (Trk) under tension-stress during distraction osteogenesis.
Acta medica Okayama 2006;60(5):267-77.
2006: Kazumi Kawata; Takanori Eguchi; Satoshi Kubota; Harumi Kawaki; Morihiko Oka; Shogo Minagi; Masaharu Takigawa
Possible role of LRP1, a CCN2 receptor, in chondrocytes.
Biochemical and biophysical research communications 2006;345(2):552-9.
2006: Gen Yosimichi; Satoshi Kubota; Takashi Nishida; Seiji Kondo; Takeshi Yanagita; Kyouji Nakao; Teruko Takano-Yamamoto; Masaharu Takigawa
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes.
Bone 2006;38(6):853-63.
2006: Mitsuhiro Hoshijima; Takako Hattori; Miho Inoue; Daisuke Araki; Hiroshi Hanagata; Akira Miyauchi; Masaharu Takigawa
CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1.
FEBS letters 2006;580(5):1376-82.
2006: Seiji Kondo; Satoshi Kubota; Yoshiki Mukudai; Norifumi H Moritani; Takashi Nishida; H Matsushita; S Matsumoto; Toshio Sugahara; Masaharu Takigawa
Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells.
Oncogene 2006;25(7):1099-110.
2006: Seiji Kondo; Noriko Tanaka; Satoshi Kubota; Yoshiki Mukudai; Gen Yosimichi; Toshio Sugahara; Masaharu Takigawa
Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor in human endothelial cells.
Molecular cancer therapeutics 2006;5(1):129-37.
2005: Masahiro Asano; Satoshi Kubota; Tohru Nakanishi; Takashi Nishida; Tomoichiro Yamaai; Gen Yosimichi; Kazumi Ohyama; Tomosada Sugimoto; Yoji Murayama; Masaharu Takigawa
Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.
Cell communication and signaling : CCS 2005;3():11.
2005: Satoshi Kubota; Yoshiki Mukudai; Norifumi H Moritani; Kyouji Nakao; Kazumi Kawata; Masaharu Takigawa
Translational repression by the cis-acting element of structure-anchored repression (CAESAR) of human ctgf/ccn2 mRNA.
FEBS letters 2005;579(17):3751-8.
2005: Kyouji Nakao; Satoshi Kubota; Hideyuki Doi; Takanori Eguchi; Morihiko Oka; Takuo Fujisawa; Takashi Nishida; Masaharu Takigawa
Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes: possible regenerative roles in articular cartilage metabolism.
Bone 2005;36(5):884-92.
2005: Yoshiki Mukudai; Satoshi Kubota; Takanori Eguchi; Seiji Kondo; Kyouji Nakao; Masaharu Takigawa
Regulation of chicken ccn2 gene by interaction between RNA cis-element and putative trans-factor during differentiation of chondrocytes.
The Journal of biological chemistry 2005;280(5):3166-77.
2005: Tomoichiro Yamaai; Tohru Nakanishi; Masahiro Asano; Kumiko Nawachi; Gen Yoshimichi; Kazumi Ohyama; Toshifumi Komori; Tomosada Sugimoto; Masaharu Takigawa
Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development.
Journal of bone and mineral metabolism 2005;23(4):280-8.
2005: Takako Hattori; Klaus von der Mark; Harumi Kawaki; Yasutaka Yutani; Satoshi Kubota; Tohru Nakanishi; Heidi Eberspaecher; Benoit de Crombrugghe; Masaharu Takigawa
Downregulation of rheumatoid arthritis-related antigen RA-A47 (HSP47/colligin-2) in chondrocytic cell lines induces apoptosis and cell-surface expression of RA-A47 in association with CD9.
Journal of cellular physiology 2005;202(1):191-204.
2004: Satoshi Kubota; Kazumi Kawata; Takeshi Yanagita; Hideyuki Doi; Takashi Kitoh; Masaharu Takigawa
Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets.
Journal of biochemistry 2004;136(3):279-82.
2004: Takashi Nishida; Satoshi Kubota; Shunji Kojima; Takuo Kuboki; Kyouji Nakao; Toshihiro Kushibiki; Yasuhiko Tabata; Masaharu Takigawa
Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(8):1308-19.
2004: Masanao Minato; Satoshi Kubota; Harumi Kawaki; Takashi Nishida; Akira Miyauchi; Hiroshi Hanagata; Tohru Nakanishi; Teruko Takano-Yamamoto; Masaharu Takigawa
Module-specific antibodies against human connective tissue growth factor: utility for structural and functional analysis of the factor as related to chondrocytes.
Journal of biochemistry 2004;135(3):347-54.
2004: Hiroaki Kadota; Tohru Nakanishi; Koji Asaumi; Tomoichiro Yamaai; Eiji Nakata; Shigeru Mitani; Kiyoshi Aoki; Ayako Aiga; Hajime Inoue; Masaharu Takigawa
Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24/CCN2) during distraction osteogenesis.
Journal of bone and mineral metabolism 2004;22(4):293-302.
2003: Harumi Kawaki; Satoshi Kubota; Masanao Minato; Norifumi H Moritani; Takako Hattori; Hiroshi Hanagata; Mamoru Kubota; Akira Miyauchi; Tohru Nakanishi; Masaharu Takigawa
Novel enzyme-linked immunosorbent assay systems for the quantitative analysis of connective tissue growth factor (CTGF/Hcs24/CCN2): detection of HTLV-I tax-induced CTGF from a human carcinoma cell line.
DNA and cell biology 2003;22(10):641-8.
2003: Satoshi Kubota; Norifumi H Moritani; Harumi Kawaki; Haruyo Mimura; Masanao Minato; Masaharu Takigawa
Transcriptional induction of connective tissue growth factor/hypertrophic chondrocyte-specific 24 gene by dexamethasone in human chondrocytic cells.
Bone 2003;33(4):694-702.
2003: Manabu Kanyama; Takuo Kuboki; Kentaro Akiyama; Kumiko Nawachi; Fabiora M Miyauchi; Hirofumi Yatani; Satoshi Kubota; Tohru Nakanishi; Masaharu Takigawa
Connective tissue growth factor expressed in rat alveolar bone regeneration sites after tooth extraction.
Archives of oral biology 2003;48(10):723-30.
2003: Takako Hattori; Harumi Kawaki; Satoshi Kubota; Yasutaka Yutani; Benoit de Crombrugghe; Klaus von der Mark; Masaharu Takigawa
Downregulation of a rheumatoid arthritis-related antigen (RA-A47) by ra-a47 antisense oligonucleotides induces inflammatory factors in chondrocytes.
Journal of cellular physiology 2003;197(1):94-102.
2003: Takuo Fujisawa; Takuo Kuboki; T Kasai; Wataru Sonoyama; S Kojima; J Uehara; C Komori; Hirofumi Yatani; T Hattori; Masaharu Takigawa
A repetitive, steady mouth opening induced an osteoarthritis-like lesion in the rabbit temporomandibular joint.
Journal of dental research 2003;82(9):731-5.
2003: Takashi Nishida; Satoshi Kubota; Tomohiro Fukunaga; Seiji Kondo; Gen Yosimichi; Tohru Nakanishi; Teruko Takano-Yamamoto; Masaharu Takigawa
CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes.
Journal of cellular physiology 2003;196(2):265-75.
2003: Takuo Kuboki; Manabu Kanyama; Tohru Nakanishi; Kentaro Akiyama; Kumiko Nawachi; Hirofumi Yatani; Kazuo Yamashita; Teruko Takano-Yamamoto; Masaharu Takigawa
Cbfa1/Runx2 gene expression in articular chondrocytes of the mice temporomandibular and knee joints in vivo.
Archives of oral biology 2003;48(7):519-25.
2003: Norifumi H Moritani; Satoshi Kubota; Takashi Nishida; Harumi Kawaki; Seiji Kondo; Toshio Sugahara; Masaharu Takigawa
Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line.
Cancer letters 2003;192(2):205-14.
2003: Masaharu Takigawa; Tohru Nakanishi; Satoshi Kubota; Takashi Nishida
Role of CTGF/HCS24/ecogenin in skeletal growth control.
Journal of cellular physiology 2003;194(3):256-66.
2003: Norifumi H Moritani; Satoshi Kubota; Takanori Eguchi; Tomohiro Fukunaga; Takashi Yamashiro; Teruko Takano-Yamamoto; Hideki Tahara; Kazumi Ohyama; Toshio Sugahara; Masaharu Takigawa
Interaction of AP-1 and the ctgf gene: a possible driver of chondrocyte hypertrophy in growth cartilage.
Journal of bone and mineral metabolism 2003;21(4):205-10.
2003: Masaharu Takigawa
CTGF/Hcs24 as a multifunctional growth factor for fibroblasts, chondrocytes and vascular endothelial cells.
Drug news & perspectives 2003;16(1):11-21.
2003: Yoshiki Mukudai; Satoshi Kubota; Masaharu Takigawa
Conserved repressive regulation of connective tissue growth factor/hypertrophic chondrocyte-specific gene 24 (ctgf/hcs24) enabled by different elements and factors among vertebrate species.
Biological chemistry 2003;384(1):1-9.
2002: Gen Yosimichi; Satoshi Kubota; Takako Hattori; Takashi Nishida; Kumiko Nawachi; Tohru Nakanishi; Masafumi Kamada; Teruko Takano-Yamamoto; Masaharu Takigawa
CTGF/Hcs24 interacts with the cytoskeletal protein actin in chondrocytes.
Biochemical and biophysical research communications 2002;299(5):755-61.
2002: Eiji Nakata; Tohru Nakanishi; Akira Kawai; Koji Asaumi; Tomoichiro Yamaai; M Asano; Takashi Nishida; Shigeru Mitani; Hajime Inoue; Masaharu Takigawa
Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture healing.
Bone 2002;31(4):441-7.
2002: Kumiko Nawachi; Miho Inoue; Satoshi Kubota; Takashi Nishida; Gen Yosimichi; Tohru Nakanishi; Manabu Kanyama; Takuo Kuboki; Hirofumi Yatani; Tomoichiro Yamaai; Masaharu Takigawa
Tyrosine kinase-type receptor ErbB4 in chondrocytes: interaction with connective tissue growth factor and distribution in cartilage.
FEBS letters 2002;528(1-3):109-13.
2002: Takanori Eguchi; Satoshi Kubota; Seiji Kondo; Takuo Kuboki; Hirofumi Yatani; Masaharu Takigawa
A novel cis-element that enhances connective tissue growth factor gene expression in chondrocytic cells.
Biochemical and biophysical research communications 2002;295(2):445-51.
2002: Takashi Nishida; Satoshi Kubota; Tohru Nakanishi; Takuo Kuboki; Gen Yosimichi; Seiji Kondo; Masaharu Takigawa
CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes.
Journal of cellular physiology 2002;192(1):55-63.
2002: Seiji Kondo; Satoshi Kubota; Tsuyoshi Shimo; Takashi Nishida; Gen Yosimichi; Takanori Eguchi; Toshio Sugahara; Masaharu Takigawa
Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases.
Carcinogenesis 2002;23(5):769-76.
2001: Tsuyoshi Shimo; Satoshi Kubota; Seiji Kondo; T Nakanishi; A Sasaki; Hiroshi Mese; T Matsumura; Masaharu Takigawa
Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line.
Cancer letters 2001;174(1):57-64.
2001: Gen Yosimichi; Tohru Nakanishi; Takashi Nishida; Takako Hattori; Teruko Takano-Yamamoto; Masaharu Takigawa
CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK).
European journal of biochemistry / FEBS 2001;268(23):6058-65.
2001: Satoshi Kubota; Yoshiki Mukudai; Takako Hattori; Takanori Eguchi; Seiji Kondo; Masaharu Takigawa
Cell-type-specific trans-activation of herpes simplex virus thymidine kinase promoter by the human T-cell leukemia virus type I Tax protein.
DNA and cell biology 2001;20(9):563-8.
2001: Satoshi Kubota; Takanori Eguchi; Tsuyoshi Shimo; Takashi Nishida; T Hattori; Seiji Kondo; Tohru Nakanishi; Masaharu Takigawa
Novel mode of processing and secretion of connective tissue growth factor/ecogenin (CTGF/Hcs24) in chondrocytic HCS-2/8 cells.
Bone 2001;29(2):155-61.
2001: Takanori Eguchi; Satoshi Kubota; Seiji Kondo; Tsuyoshi Shimo; Takako Hattori; Tohru Nakanishi; Takuo Kuboki; H Yatani; Masaharu Takigawa
Regulatory mechanism of human connective tissue growth factor (CTGF/Hcs24) gene expression in a human chondrocytic cell line, HCS-2/8.
Journal of biochemistry 2001;130(1):79-87.
2001: Tohru Nakanishi; Tomoichiro Yamaai; Masahiro Asano; Kumiko Nawachi; M Suzuki; Tomosada Sugimoto; Masaharu Takigawa
Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism.
Biochemical and biophysical research communications 2001;281(3):678-81.
2001: Takako Hattori; Satoshi Kubota; Yasutaka Yutani; T Fujisawa; Tohru Nakanishi; K Takahashi; Masaharu Takigawa
Change in cellular localization of a rheumatoid arthritis-related antigen (RA-A47) with downregulation upon stimulation by inflammatory cytokines in chondrocytes.
Journal of cellular physiology 2001;186(2):268-281.
2001: Tsuyoshi Shimo; Tohru Nakanishi; Takashi Nishida; Masahiro Asano; A Sasaki; Manabu Kanyama; Takuo Kuboki; T Matsumura; Masaharu Takigawa
Involvement of CTGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesis.
Oncology 2001;61(4):315-22.
2000: Seiji Kondo; Satoshi Kubota; Takanori Eguchi; Takako Hattori; Tohru Nakanishi; Toshio Sugahara; Masaharu Takigawa
Characterization of a mouse ctgf 3'-UTR segment that mediates repressive regulation of gene expression.
Biochemical and biophysical research communications 2000;278(1):119-24.
2000: Satoshi Kubota; Seiji Kondo; Takanori Eguchi; Takako Hattori; Tohru Nakanishi; R J Pomerantz; Masaharu Takigawa
Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/hcs24) gene: similarities to retroviral RNA-protein interactions.
Oncogene 2000;19(41):4773-86.
2000: Takashi Nishida; Tohru Nakanishi; Masahiro Asano; Tsuyoshi Shimo; Masaharu Takigawa
Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro.
Journal of cellular physiology 2000;184(2):197-206.
2000: Koji Asaumi; Tohru Nakanishi; H Asahara; Hajime Inoue; Masaharu Takigawa
Expression of neurotrophins and their receptors (TRK) during fracture healing.
Bone 2000;26(6):625-33.
2000: Satoshi Kubota; Takako Hattori; Tsuyoshi Shimo; Tohru Nakanishi; Masaharu Takigawa
Novel intracellular effects of human connective tissue growth factor expressed in Cos-7 cells.
FEBS letters 2000;474(1):58-62.
2000: Manabu Kanyama; Takuo Kuboki; S Kojima; Takuo Fujisawa; T Hattori; Masaharu Takigawa; Atsushi Yamashita
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids of patients with temporomandibular joint osteoarthritis.
Journal of orofacial pain 2000;14(1):20-30.
2000: Takako Hattori; K Takahash; Yasutaka Yutani; T Fujisawa; Tohru Nakanishi; Masaharu Takigawa
Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47.
Journal of bone and mineral metabolism 2000;18(6):328-34.
2000: Tohru Nakanishi; Takashi Nishida; Tsuyoshi Shimo; K Kobayashi; T Kubo; T Tamatani; K Tezuka; Masaharu Takigawa
Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.
Endocrinology 2000;141(1):264-73.
1999: Takuo Kuboki; Tohru Nakanishi; Manabu Kanyama; Wataru Sonoyama; Takuo Fujisawa; K Kobayashi; T Ikeda; T Kubo; Atsushi Yamashita; Masaharu Takigawa
Direct adenovirus-mediated gene delivery to the temporomandibular joint in guinea-pigs.
Archives of oral biology 1999;44(9):701-9.
1999: Tsuyoshi Shimo; Tohru Nakanishi; Takashi Nishida; Masahiro Asano; Manabu Kanyama; Takuo Kuboki; T Tamatani; K Tezuka; M Takemura; T Matsumura; Masaharu Takigawa
Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo.
Journal of biochemistry 1999;126(1):137-45.
1999: Takuo Kuboki; T Hattori; T Mizushima; Manabu Kanyama; T Fujisawa; Atsushi Yamashita; Masaharu Takigawa
Detection of specific antibodies against human cultured chondrosarcoma (HCS-2/8) and osteosarcoma (Saos-2) cells in the serum of patients with osteoarthritis of the temporomandibular joint.
Archives of oral biology 1999;44(5):403-14.
1999: T Fujisawa; Takako Hattori; K Takahashi; Takuo Kuboki; A Yamashita; Masaharu Takigawa
Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1.
Journal of biochemistry 1999;125(5):966-75.
1999: Satoshi Kubota; Takako Hattori; Tohru Nakanishi; Masaharu Takigawa
Involvement of cis-acting repressive element(s) in the 3'-untranslated region of human connective tissue growth factor gene.
FEBS letters 1999;450(1-2):84-8.
1998: T Tamatani; H Kobayashi; K Tezuka; Shinji Sakamoto; K Suzuki; Tohru Nakanishi; Masaharu Takigawa; T Miyano
Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia.
Biochemical and biophysical research communications 1998;251(3):748-52.
1998: Tsuyoshi Shimo; Tohru Nakanishi; Y Kimura; Takashi Nishida; K Ishizeki; T Matsumura; Masaharu Takigawa
Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells.
Journal of biochemistry 1998;124(1):130-40.
1998: Takashi Nishida; Tohru Nakanishi; Tsuyoshi Shimo; Masahiro Asano; Takako Hattori; T Tamatani; K Tezuka; Masaharu Takigawa
Demonstration of receptors specific for connective tissue growth factor on a human chondrocytic cell line (HCS-2/8).
Biochemical and biophysical research communications 1998;247(3):905-9.
1998: Takako Hattori; T Fujisawa; K Sasaki; Yasutaka Yutani; Tohru Nakanishi; K Takahashi; Masaharu Takigawa
Isolation and characterization of a rheumatoid arthritis-specific antigen (RA-A47) from a human chondrocytic cell line (HCS-2/8).
Biochemical and biophysical research communications 1998;245(3):679-83.
1998: K Sasaki; Takako Hattori; T Fujisawa; K Takahashi; Hajime Inoue; Masaharu Takigawa
Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes.
Journal of biochemistry 1998;123(3):431-9.
1997: Masaharu Takigawa; T Okawa; H Pan; C Aoki; K Takahashi; J Zue; F Suzuki; A Kinoshita
Insulin-like growth factors I and II are autocrine factors in stimulating proteoglycan synthesis, a marker of differentiated chondrocytes, acting through their respective receptors on a clonal human chondrosarcoma-derived chondrocyte cell line, HCS-2/8.
Endocrinology 1997;138(10):4390-400.
1997: Tohru Nakanishi; Y Kimura; T Tamura; H Ichikawa; Y Yamaai; Tomosada Sugimoto; Masaharu Takigawa
Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA.
Biochemical and biophysical research communications 1997;234(1):206-10.
1996: T Tamura; T Nakanishi; Y Kimura; T Hattori; K Sasaki; H Norimatsu; K Takahashi; Masaharu Takigawa
Nitric oxide mediates interleukin-1-induced matrix degradation and basic fibroblast growth factor release in cultured rabbit articular chondrocytes: a possible mechanism of pathological neovascularization in arthritis.
Endocrinology 1996;137(9):3729-37.
1995: Y Ohba; Y Goto; Y Kimura; F Suzuki; T Hisa; K Takahashi; Masaharu Takigawa
Purification of an angiogenesis inhibitor from culture medium conditioned by a human chondrosarcoma-derived chondrocytic cell line, HCS-2/8.
Biochimica et biophysica acta 1995;1245(1):1-8.
1994: Tohru Nakanishi; K Ohyama; C Aoki; A Kudo; Takako Hattori; K Takahashi; S Taniguchi; Masaharu Takigawa
Expression of trkC in a mouse osteoblastic cell line and its response to neurotrophin-3.
Biochemical and biophysical research communications 1994;203(2):1268-74.