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Masaharu Takigawa
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Chemicals & Drugs
Anatomy
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Physiology
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57
Kubota, Satoshi
36
Nakanishi, Tohru
32
Nishida, Takashi
22
Kondo, Seiji
22
Hattori, Takako
19
Kuboki, Takuo
17
Eguchi, Takanori
16
Kawaki, Harumi
14
Shimo, Tsuyoshi
10
Kawata, Kazumi
10
Yosimichi, Gen
9
Mukudai, Yoshiki
8
Takano-Yamamoto, Teruko
8
Kanyama, Manabu
7
Asano, Masahiro
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All Publications
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2010: Kawata Kazumi; Kubota Satoshi; Eguchi Takanori; Moritani Norifumi H; Shimo Tsuyoshi; Kondo Seiji; Nishida Takashi; Minagi Shogo; Takigawa Masaharu
Role of the low-density lipoprotein receptor-related protein-1 in regulation of chondrocyte differentiation.
Journal of cellular physiology 2010;222(1):138-48.
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2009: Aoyama Eriko; Hattori Takako; Hoshijima Mitsuhiro; Araki Daisuke; Nishida Takashi; Kubota Satoshi; Takigawa Masaharu
N-terminal domains of CCN family 2/connective tissue growth factor bind to aggrecan.
The Biochemical journal 2009;420(3):413-20.
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2009: Ohgawara Toshihiro; Kubota Satoshi; Kawaki Harumi; Kondo Seiji; Eguchi Takanori; Kurio Naito; Aoyama Eriko; Sasaki Akira; Takigawa Masaharu
Regulation of chondrocytic phenotype by micro RNA 18a: involvement of Ccn2/Ctgf as a major target gene.
FEBS letters 2009;583(6):1006-10.
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2009: Maeda Azusa; Nishida Takashi; Aoyama Eriko; Kubota Satoshi; Lyons Karen M; Kuboki Takuo; Takigawa Masaharu
CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes.
Journal of biochemistry 2009;145(2):207-16.
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2008: Mukudai Yoshiki; Kubota Satoshi; Kawaki Harumi; Kondo Seiji; Eguchi Takanori; Sumiyoshi Kumi; Ohgawara Toshihiro; Shimo Tsuyoshi; Takigawa Masaharu
Posttranscriptional regulation of chicken ccn2 gene expression by nucleophosmin/B23 during chondrocyte differentiation.
Molecular and cellular biology 2008;28(19):6134-47.
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2008: Vincourt Jean-Baptiste; Vignaud Jean-Michel; Lionneton Frédéric; Sirveaux François; Kawaki Harumi; Marchal Sophie; Lomazzi Sandra; Plénat François; Guillemin François; Netter Patrick; Takigawa Masaharu; Mainard Didier; Magdalou Jacques
Increased expression of matrilin-3 not only in osteoarthritic articular cartilage but also in cartilage-forming tumors, and down-regulation of SOX9 via epidermal growth factor domain 1-dependent signaling.
Arthritis and rheumatism 2008;58(9):2798-808.
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2008: Kuroda Chisa; Kubota Satoshi; Kawata Kazumi; Aoyama Eriko; Sumiyoshi Kumi; Oka Morihiko; Inoue Miho; Minagi Shogo; Takigawa Masaharu
Distribution, gene expression, and functional role of EphA4 during ossification.
Biochemical and biophysical research communications 2008;374(1):22-7.
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2008: Shimo Tsuyoshi; Kubota Satoshi; Goda Takeshi; Yoshihama Yasuto; Kurio Naito; Nishida Takashi; Ng Poh-Sing; Endo Koki; Takigawa Masaharu; Sasakii Akira
Clinical significance and pathogenic function of connective tissue growth factor (CTGF/CCN2) in osteolytic mandibular squamous cell carcinoma.
Anticancer research 2008;28(4C):2343-8.
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2008: Motoki Takahiro; Sugiura Yoshihiro; Matsumoto Yohsuke; Tsuji Tomoe; Kubota Satoshi; Takigawa Masaharu; Gohda Eiichi
Induction of hepatocyte growth factor expression by maleic acid in human fibroblasts through MAPK activation.
Journal of cellular biochemistry 2008;104(4):1465-76.
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2008: Fujisawa T; Hattori T; Ono M; Uehara J; Kubota S; Kuboki T; Takigawa M
CCN family 2/connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2008;16(7):787-95.
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2008: Kikuchi Takeshi; Kubota Satoshi; Asaumi Koji; Kawaki Harumi; Nishida Takashi; Kawata Kazumi; Mitani Shigeru; Tabata Yasuhiko; Ozaki Toshifumi; Takigawa Masaharu
Promotion of bone regeneration by CCN2 incorporated into gelatin hydrogel.
Tissue engineering. Part A 2008;14(6):1089-98.
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2008: Hattori Takako; Coustry Francoise; Stephens Shelley; Eberspaecher Heidi; Takigawa Masaharu; Yasuda Hideyo; de Crombrugghe Benoit
Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5.
Nucleic acids research 2008;36(9):3011-24.
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2008: Doi Hideyuki; Nishida Keiichiro; Yorimitsu Masanori; Komiyama Takamitsu; Kadota Yasutaka; Tetsunaga Tomonori; Yoshida Aki; Kubota Satoshi; Takigawa Masaharu; Ozaki Toshifumi
Interleukin-4 downregulates the cyclic tensile stress-induced matrix metalloproteinases-13 and cathepsin B expression by rat normal chondrocytes.
Acta medica Okayama 2008;62(2):119-26.
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2008: Koitabashi Norimichi; Arai Masashi; Niwano Kazuo; Watanabe Atai; Endoh Michiko; Suguta Masahiko; Yokoyama Tomoyuki; Tada Hiroshi; Toyama Takuji; Adachi Hitoshi; Naito Shigeto; Oshima Shigeru; Nishida Takashi; Kubota Satoshi; Takigawa Masaharu; Kurabayashi Masahiko
Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure.
European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology 2008;10(4):373-9.
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2008: Heino Terhi J; Chagin Andrei S; Takigawa Masaharu; Sävendahl Lars
Effects of alendronate and pamidronate on cultured rat metatarsal bones: failure to prevent dexamethasone-induced growth retardation.
Bone 2008;42(4):702-9.
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2008: Eguchi Takanori; Kubota Satoshi; Kawata Kazumi; Mukudai Yoshiki; Uehara Junji; Ohgawara Toshihiro; Ibaragi Soichiro; Sasaki Akira; Kuboki Takuo; Takigawa Masaharu
Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene.
Molecular and cellular biology 2008;28(7):2391-413.
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2008: Kawaki Harumi; Kubota Satoshi; Suzuki Akiko; Yamada Tomohiro; Matsumura Tatsushi; Mandai Toshiko; Yao Mayumi; Maeda Takeyasu; Lyons Karen M; Takigawa Masaharu
Functional requirement of CCN2 for intramembranous bone formation in embryonic mice.
Biochemical and biophysical research communications 2008;366(2):450-6.
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2008: Nishida Takashi; Maeda Azusa; Kubota Satoshi; Takigawa Masaharu
Role of mechanical-stress inducible protein Hcs24/CTGF/CCN2 in cartilage growth and regeneration: mechanical stress induces expression of Hcs24/CTGF/CCN2 in a human chondrocytic cell line HCS-2/8, rabbit costal chondrocytes and meniscus tissue cells.
Biorheology 2008;45(3-4):289-99.
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2008: Ono Mitsuaki; Kubota Satoshi; Fujisawa Takuo; Sonoyama Wataru; Kawaki Harumi; Akiyama Kentaro; Shimono Kengo; Oshima Masamitsu; Nishida Takashi; Yoshida Yasuhiro; Suzuki Kazuomi; Takigawa Masaharu; Kuboki Takuo
Promotion of hydroxyapatite-associated, stem cell-based bone regeneration by CCN2.
Cell transplantation 2008;17(1-2):231-40.
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2007: Oka Morihiko; Kubota Satoshi; Kondo Seiji; Eguchi Takanori; Kuroda Chisa; Kawata Kazumi; Minagi Shogo; Takigawa Masaharu
Gene expression and distribution of connective tissue growth factor (CCN2/CTGF) during secondary ossification center formation.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2007;55(12):1245-55.
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2007: Kubota S; Yeger H; Perbal B; Takigawa M
Report on the fourth international workshop on the CCN family of genes.
Journal of cell communication and signaling 2007;1(1):59-65.
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2007: Nishida Takashi; Kawaki Harumi; Baxter Ruth M; Deyoung R Andrea; Takigawa Masaharu; Lyons Karen M
CCN2 (Connective Tissue Growth Factor) is essential for extracellular matrix production and integrin signaling in chondrocytes.
Journal of cell communication and signaling 2007;1(1):45-58.
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2007: Ono Mitsuaki; Kubota Satoshi; Fujisawa Takuo; Sonoyama Wataru; Kawaki Harumi; Akiyama Kentaro; Oshima Masamitsu; Nishida Takashi; Yoshida Yasuhiro; Suzuki Kazuomi; Takigawa Masaharu; Kuboki Takuo
Promotion of attachment of human bone marrow stromal cells by CCN2.
Biochemical and biophysical research communications 2007;357(1):20-5.
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2007: Yanagita Takeshi; Kubota Satoshi; Kawaki Harumi; Kawata Kazumi; Kondo Seiji; Takano-Yamamoto Teruko; Tanaka Shinji; Takigawa Masaharu
Expression and physiological role of CCN4/Wnt-induced secreted protein 1 mRNA splicing variants in chondrocytes.
The FEBS journal 2007;274(7):1655-65.
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2007: Eguchi Takanori; Kubota Satoshi; Kawata Kazumi; Mukudai Yoshiki; Ohgawara Toshihiro; Miyazono Kohei; Nakao Kyouji; Kondo Seiji; Takigawa Masaharu
Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines.
Biochimie 2007;89(3):278-88.
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2007: Kubota Satoshi; Takigawa Masaharu
Role of CCN2/CTGF/Hcs24 in bone growth.
International review of cytology 2007;257():1-41.
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2007: Kubota Satoshi; Takigawa Masaharu
CCN family proteins and angiogenesis: from embryo to adulthood.
Angiogenesis 2007;10(1):1-11.
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2006: Kubota S; Kawaki H; Kondo S; Yosimichi G; Minato M; Nishida T; Hanagata H; Miyauchi A; Takigawa M
Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in culture.
Biochimie 2006;88(12):1973-81.
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2006: Aiga Ayako; Asaumi Koji; Lee You-Jin; Kadota Hiroaki; Mitani Shigeru; Ozaki Toshifumi; Takigawa Masaharu
Expression of neurotrophins and their receptors tropomyosin-related kinases (Trk) under tension-stress during distraction osteogenesis.
Acta medica Okayama 2006;60(5):267-77.
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2006: Kawata Kazumi; Eguchi Takanori; Kubota Satoshi; Kawaki Harumi; Oka Morihiko; Minagi Shogo; Takigawa Masaharu
Possible role of LRP1, a CCN2 receptor, in chondrocytes.
Biochemical and biophysical research communications 2006;345(2):552-9.
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2006: Yosimichi Gen; Kubota Satoshi; Nishida Takashi; Kondo Seiji; Yanagita Takeshi; Nakao Kyouji; Takano-Yamamoto Teruko; Takigawa Masaharu
Roles of PKC, PI3K and JNK in multiple transduction of CCN2/CTGF signals in chondrocytes.
Bone 2006;38(6):853-63.
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2006: Hoshijima Mitsuhiro; Hattori Takako; Inoue Miho; Araki Daisuke; Hanagata Hiroshi; Miyauchi Akira; Takigawa Masaharu
CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1.
FEBS letters 2006;580(5):1376-82.
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2006: Kondo S; Kubota S; Mukudai Y; Moritani N; Nishida T; Matsushita H; Matsumoto S; Sugahara T; Takigawa M
Hypoxic regulation of stability of connective tissue growth factor/CCN2 mRNA by 3'-untranslated region interacting with a cellular protein in human chondrosarcoma cells.
Oncogene 2006;25(7):1099-110.
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2006: Kondo Seiji; Tanaka Noriko; Kubota Satoshi; Mukudai Yoshiki; Yosimichi Gen; Sugahara Toshio; Takigawa Masaharu
Novel angiogenic inhibitor DN-9693 that inhibits post-transcriptional induction of connective tissue growth factor (CTGF/CCN2) by vascular endothelial growth factor in human endothelial cells.
Molecular cancer therapeutics 2006;5(1):129-37.
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2005: Asano Masahiro; Kubota Satoshi; Nakanishi Tohru; Nishida Takashi; Yamaai Tomoichiro; Yosimichi Gen; Ohyama Kazumi; Sugimoto Tomosada; Murayama Yoji; Takigawa Masaharu
Effect of connective tissue growth factor (CCN2/CTGF) on proliferation and differentiation of mouse periodontal ligament-derived cells.
Cell communication and signaling : CCS 2005;3():11.
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2005: Kubota Satoshi; Mukudai Yoshiki; Moritani Norifumi H; Nakao Kyouji; Kawata Kazumi; Takigawa Masaharu
Translational repression by the cis-acting element of structure-anchored repression (CAESAR) of human ctgf/ccn2 mRNA.
FEBS letters 2005;579(17):3751-8.
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2005: Nakao Kyouji; Kubota Satoshi; Doi Hideyuki; Eguchi Takanori; Oka Morihiko; Fujisawa Takuo; Nishida Takashi; Takigawa Masaharu
Collaborative action of M-CSF and CTGF/CCN2 in articular chondrocytes: possible regenerative roles in articular cartilage metabolism.
Bone 2005;36(5):884-92.
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2005: Mukudai Yoshiki; Kubota Satoshi; Eguchi Takanori; Kondo Seiji; Nakao Kyouji; Takigawa Masaharu
Regulation of chicken ccn2 gene by interaction between RNA cis-element and putative trans-factor during differentiation of chondrocytes.
The Journal of biological chemistry 2005;280(5):3166-77.
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2005: Hattori Takako; von der Mark Klaus; Kawaki Harumi; Yutani Yasutaka; Kubota Satoshi; Nakanishi Tohru; Eberspaecher Heidi; de Crombrugghe Benoit; Takigawa Masaharu
Downregulation of rheumatoid arthritis-related antigen RA-A47 (HSP47/colligin-2) in chondrocytic cell lines induces apoptosis and cell-surface expression of RA-A47 in association with CD9.
Journal of cellular physiology 2005;202(1):191-204.
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2005: Yamaai Tomoichiro; Nakanishi Tohru; Asano Masahiro; Nawachi Kumiko; Yoshimichi Gen; Ohyama Kazumi; Komori Toshifumi; Sugimoto Tomosada; Takigawa Masaharu
Gene expression of connective tissue growth factor (CTGF/CCN2) in calcifying tissues of normal and cbfa1-null mutant mice in late stage of embryonic development.
Journal of bone and mineral metabolism 2005;23(4):280-8.
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2004: Kubota Satoshi; Kawata Kazumi; Yanagita Takeshi; Doi Hideyuki; Kitoh Takashi; Takigawa Masaharu
Abundant retention and release of connective tissue growth factor (CTGF/CCN2) by platelets.
Journal of biochemistry 2004;136(3):279-82.
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2004: Nishida Takashi; Kubota Satoshi; Kojima Shunji; Kuboki Takuo; Nakao Kyouji; Kushibiki Toshihiro; Tabata Yasuhiko; Takigawa Masaharu
Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor).
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2004;19(8):1308-19.
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2004: Minato Masanao; Kubota Satoshi; Kawaki Harumi; Nishida Takashi; Miyauchi Akira; Hanagata Hiroshi; Nakanishi Tohru; Takano-Yamamoto Teruko; Takigawa Masaharu
Module-specific antibodies against human connective tissue growth factor: utility for structural and functional analysis of the factor as related to chondrocytes.
Journal of biochemistry 2004;135(3):347-54.
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2004: Kadota Hiroaki; Nakanishi Tohru; Asaumi Koji; Yamaai Tomoichiro; Nakata Eiji; Mitani Shigeru; Aoki Kiyoshi; Aiga Ayako; Inoue Hajime; Takigawa Masaharu
Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24/CCN2) during distraction osteogenesis.
Journal of bone and mineral metabolism 2004;22(4):293-302.
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2003: Kawaki Harumi; Kubota Satoshi; Minato Masanao; Moritani Norifumi H; Hattori Takako; Hanagata Hiroshi; Kubota Mamoru; Miyauchi Akira; Nakanishi Tohru; Takigawa Masaharu
Novel enzyme-linked immunosorbent assay systems for the quantitative analysis of connective tissue growth factor (CTGF/Hcs24/CCN2): detection of HTLV-I tax-induced CTGF from a human carcinoma cell line.
DNA and cell biology 2003;22(10):641-8.
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2003: Kubota Satoshi; Moritani Norifumi H; Kawaki Harumi; Mimura Haruyo; Minato Masanao; Takigawa Masaharu
Transcriptional induction of connective tissue growth factor/hypertrophic chondrocyte-specific 24 gene by dexamethasone in human chondrocytic cells.
Bone 2003;33(4):694-702.
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2003: Kanyama Manabu; Kuboki Takuo; Akiyama Kentaro; Nawachi Kumiko; Miyauchi Fabiora M; Yatani Hirofumi; Kubota Satoshi; Nakanishi Tohru; Takigawa Masaharu
Connective tissue growth factor expressed in rat alveolar bone regeneration sites after tooth extraction.
Archives of oral biology 2003;48(10):723-30.
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2003: Hattori Takako; Kawaki Harumi; Kubota Satoshi; Yutani Yasutaka; de Crombrugghe Benoit; von der Mark Klaus; Takigawa Masaharu
Downregulation of a rheumatoid arthritis-related antigen (RA-A47) by ra-a47 antisense oligonucleotides induces inflammatory factors in chondrocytes.
Journal of cellular physiology 2003;197(1):94-102.
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2003: Fujisawa T; Kuboki T; Kasai T; Sonoyama W; Kojima S; Uehara J; Komori C; Yatani H; Hattori T; Takigawa M
A repetitive, steady mouth opening induced an osteoarthritis-like lesion in the rabbit temporomandibular joint.
Journal of dental research 2003;82(9):731-5.
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2003: Nishida Takashi; Kubota Satoshi; Fukunaga Tomohiro; Kondo Seiji; Yosimichi Gen; Nakanishi Tohru; Takano-Yamamoto Teruko; Takigawa Masaharu
CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes.
Journal of cellular physiology 2003;196(2):265-75.
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2003: Kuboki Takuo; Kanyama Manabu; Nakanishi Tohru; Akiyama Kentaro; Nawachi Kumiko; Yatani Hirofumi; Yamashita Kazuo; Takano-Yamamoto Teruko; Takigawa Masaharu
Cbfa1/Runx2 gene expression in articular chondrocytes of the mice temporomandibular and knee joints in vivo.
Archives of oral biology 2003;48(7):519-25.
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2003: Moritani Norifumi H; Kubota Satoshi; Nishida Takashi; Kawaki Harumi; Kondo Seiji; Sugahara Toshio; Takigawa Masaharu
Suppressive effect of overexpressed connective tissue growth factor on tumor cell growth in a human oral squamous cell carcinoma-derived cell line.
Cancer letters 2003;192(2):205-14.
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2003: Takigawa Masaharu; Nakanishi Tohru; Kubota Satoshi; Nishida Takashi
Role of CTGF/HCS24/ecogenin in skeletal growth control.
Journal of cellular physiology 2003;194(3):256-66.
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2003: Takigawa Masaharu
CTGF/Hcs24 as a multifunctional growth factor for fibroblasts, chondrocytes and vascular endothelial cells.
Drug news & perspectives 2003;16(1):11-21.
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2003: Mukudai Yoshiki; Kubota Satoshi; Takigawa Masaharu
Conserved repressive regulation of connective tissue growth factor/hypertrophic chondrocyte-specific gene 24 (ctgf/hcs24) enabled by different elements and factors among vertebrate species.
Biological chemistry 2003;384(1):1-9.
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2003: Moritani Norifumi H; Kubota Satoshi; Eguchi Takanori; Fukunaga Tomohiro; Yamashiro Takashi; Takano-Yamamoto Teruko; Tahara Hideki; Ohyama Kazumi; Sugahara Toshio; Takigawa Masaharu
Interaction of AP-1 and the ctgf gene: a possible driver of chondrocyte hypertrophy in growth cartilage.
Journal of bone and mineral metabolism 2003;21(4):205-10.
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2002: Yosimichi Gen; Kubota Satoshi; Hattori Takako; Nishida Takashi; Nawachi Kumiko; Nakanishi Tohru; Kamada Masafumi; Takano-Yamamoto Teruko; Takigawa Masaharu
CTGF/Hcs24 interacts with the cytoskeletal protein actin in chondrocytes.
Biochemical and biophysical research communications 2002;299(5):755-61.
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2002: Nakata E; Nakanishi T; Kawai A; Asaumi K; Yamaai T; Asano M; Nishida T; Mitani S; Inoue H; Takigawa M
Expression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 (CTGF/Hcs24) during fracture healing.
Bone 2002;31(4):441-7.
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2002: Nawachi Kumiko; Inoue Miho; Kubota Satoshi; Nishida Takashi; Yosimichi Gen; Nakanishi Tohru; Kanyama Manabu; Kuboki Takuo; Yatani Hirofumi; Yamaai Tomoichiro; Takigawa Masaharu
Tyrosine kinase-type receptor ErbB4 in chondrocytes: interaction with connective tissue growth factor and distribution in cartilage.
FEBS letters 2002;528(1-3):109-13.
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2002: Eguchi Takanori; Kubota Satoshi; Kondo Seiji; Kuboki Takuo; Yatani Hirofumi; Takigawa Masaharu
A novel cis-element that enhances connective tissue growth factor gene expression in chondrocytic cells.
Biochemical and biophysical research communications 2002;295(2):445-51.
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2002: Nishida Takashi; Kubota Satoshi; Nakanishi Tohru; Kuboki Takuo; Yosimichi Gen; Kondo Seiji; Takigawa Masaharu
CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes.
Journal of cellular physiology 2002;192(1):55-63.
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2002: Kondo Seiji; Kubota Satoshi; Shimo Tsuyoshi; Nishida Takashi; Yosimichi Gen; Eguchi Takanori; Sugahara Toshio; Takigawa Masaharu
Connective tissue growth factor increased by hypoxia may initiate angiogenesis in collaboration with matrix metalloproteinases.
Carcinogenesis 2002;23(5):769-76.
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2001: Yosimichi G; Nakanishi T; Nishida T; Hattori T; Takano-Yamamoto T; Takigawa M
CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK).
European journal of biochemistry / FEBS 2001;268(23):6058-65.
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2001: Shimo T; Kubota S; Kondo S; Nakanishi T; Sasaki A; Mese H; Matsumura T; Takigawa M
Connective tissue growth factor as a major angiogenic agent that is induced by hypoxia in a human breast cancer cell line.
Cancer letters 2001;174(1):57-64.
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2001: Kubota S; Mukudai Y; Hattori T; Eguchi T; Kondo S; Takigawa M
Cell-type-specific trans-activation of herpes simplex virus thymidine kinase promoter by the human T-cell leukemia virus type I Tax protein.
DNA and cell biology 2001;20(9):563-8.
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2001: Kubota S; Eguchi T; Shimo T; Nishida T; Hattori T; Kondo S; Nakanishi T; Takigawa M
Novel mode of processing and secretion of connective tissue growth factor/ecogenin (CTGF/Hcs24) in chondrocytic HCS-2/8 cells.
Bone 2001;29(2):155-61.
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2001: Eguchi T; Kubota S; Kondo S; Shimo T; Hattori T; Nakanishi T; Kuboki T; Yatani H; Takigawa M
Regulatory mechanism of human connective tissue growth factor (CTGF/Hcs24) gene expression in a human chondrocytic cell line, HCS-2/8.
Journal of biochemistry 2001;130(1):79-87.
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2001: Nakanishi T; Yamaai T; Asano M; Nawachi K; Suzuki M; Sugimoto T; Takigawa M
Overexpression of connective tissue growth factor/hypertrophic chondrocyte-specific gene product 24 decreases bone density in adult mice and induces dwarfism.
Biochemical and biophysical research communications 2001;281(3):678-81.
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2001: Hattori T; Kubota S; Yutani Y; Fujisawa T; Nakanishi T; Takahashi K; Takigawa M
Change in cellular localization of a rheumatoid arthritis-related antigen (RA-A47) with downregulation upon stimulation by inflammatory cytokines in chondrocytes.
Journal of cellular physiology 2001;186(2):268-281.
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2001: Shimo T; Nakanishi T; Nishida T; Asano M; Sasaki A; Kanyama M; Kuboki T; Matsumura T; Takigawa M
Involvement of CTGF, a hypertrophic chondrocyte-specific gene product, in tumor angiogenesis.
Oncology 2001;61(4):315-22.
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2000: Kondo S; Kubota S; Eguchi T; Hattori T; Nakanishi T; Sugahara T; Takigawa M
Characterization of a mouse ctgf 3'-UTR segment that mediates repressive regulation of gene expression.
Biochemical and biophysical research communications 2000;278(1):119-24.
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2000: Kubota S; Kondo S; Eguchi T; Hattori T; Nakanishi T; Pomerantz R J; Takigawa M
Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/hcs24) gene: similarities to retroviral RNA-protein interactions.
Oncogene 2000;19(41):4773-86.
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2000: Nishida T; Nakanishi T; Asano M; Shimo T; Takigawa M
Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro.
Journal of cellular physiology 2000;184(2):197-206.
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2000: Asaumi K; Nakanishi T; Asahara H; Inoue H; Takigawa M
Expression of neurotrophins and their receptors (TRK) during fracture healing.
Bone 2000;26(6):625-33.
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2000: Kubota S; Hattori T; Shimo T; Nakanishi T; Takigawa M
Novel intracellular effects of human connective tissue growth factor expressed in Cos-7 cells.
FEBS letters 2000;474(1):58-62.
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2000: Nakanishi T; Nishida T; Shimo T; Kobayashi K; Kubo T; Tamatani T; Tezuka K; Takigawa M
Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture.
Endocrinology 2000;141(1):264-73.
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2000: Kanyama M; Kuboki T; Kojima S; Fujisawa T; Hattori T; Takigawa M; Yamashita A
Matrix metalloproteinases and tissue inhibitors of metalloproteinases in synovial fluids of patients with temporomandibular joint osteoarthritis.
Journal of orofacial pain 2000;14(1):20-30.
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2000: Hattori T; Takahash K; Yutani Y; Fujisawa T; Nakanishi T; Takigawa M
Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47.
Journal of bone and mineral metabolism 2000;18(6):328-34.
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1999: Kuboki T; Nakanishi T; Kanyama M; Sonoyama W; Fujisawa T; Kobayashi K; Ikeda T; Kubo T; Yamashita A; Takigawa M
Direct adenovirus-mediated gene delivery to the temporomandibular joint in guinea-pigs.
Archives of oral biology 1999;44(9):701-9.
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1999: Shimo T; Nakanishi T; Nishida T; Asano M; Kanyama M; Kuboki T; Tamatani T; Tezuka K; Takemura M; Matsumura T; Takigawa M
Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo.
Journal of biochemistry 1999;126(1):137-45.
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1999: Kuboki T; Hattori T; Mizushima T; Kanyama M; Fujisawa T; Yamashita A; Takigawa M
Detection of specific antibodies against human cultured chondrosarcoma (HCS-2/8) and osteosarcoma (Saos-2) cells in the serum of patients with osteoarthritis of the temporomandibular joint.
Archives of oral biology 1999;44(5):403-14.
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1999: Fujisawa T; Hattori T; Takahashi K; Kuboki T; Yamashita A; Takigawa M
Cyclic mechanical stress induces extracellular matrix degradation in cultured chondrocytes via gene expression of matrix metalloproteinases and interleukin-1.
Journal of biochemistry 1999;125(5):966-75.
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1999: Kubota S; Hattori T; Nakanishi T; Takigawa M
Involvement of cis-acting repressive element(s) in the 3'-untranslated region of human connective tissue growth factor gene.
FEBS letters 1999;450(1-2):84-8.
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1998: Tamatani T; Kobayashi H; Tezuka K; Sakamoto S; Suzuki K; Nakanishi T; Takigawa M; Miyano T
Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia.
Biochemical and biophysical research communications 1998;251(3):748-52.
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1998: Shimo T; Nakanishi T; Kimura Y; Nishida T; Ishizeki K; Matsumura T; Takigawa M
Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells.
Journal of biochemistry 1998;124(1):130-40.
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1998: Nishida T; Nakanishi T; Shimo T; Asano M; Hattori T; Tamatani T; Tezuka K; Takigawa M
Demonstration of receptors specific for connective tissue growth factor on a human chondrocytic cell line (HCS-2/8).
Biochemical and biophysical research communications 1998;247(3):905-9.
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1998: Hattori T; Fujisawa T; Sasaki K; Yutani Y; Nakanishi T; Takahashi K; Takigawa M
Isolation and characterization of a rheumatoid arthritis-specific antigen (RA-A47) from a human chondrocytic cell line (HCS-2/8).
Biochemical and biophysical research communications 1998;245(3):679-83.
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1998: Sasaki K; Hattori T; Fujisawa T; Takahashi K; Inoue H; Takigawa M
Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes.
Journal of biochemistry 1998;123(3):431-9.
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1997: Takigawa M; Okawa T; Pan H; Aoki C; Takahashi K; Zue J; Suzuki F; Kinoshita A
Insulin-like growth factors I and II are autocrine factors in stimulating proteoglycan synthesis, a marker of differentiated chondrocytes, acting through their respective receptors on a clonal human chondrosarcoma-derived chondrocyte cell line, HCS-2/8.
Endocrinology 1997;138(10):4390-400.
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1997: Nakanishi T; Kimura Y; Tamura T; Ichikawa H; Yamaai Y; Sugimoto T; Takigawa M
Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA.
Biochemical and biophysical research communications 1997;234(1):206-10.
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1996: Tamura T; Nakanishi T; Kimura Y; Hattori T; Sasaki K; Norimatsu H; Takahashi K; Takigawa M
Nitric oxide mediates interleukin-1-induced matrix degradation and basic fibroblast growth factor release in cultured rabbit articular chondrocytes: a possible mechanism of pathological neovascularization in arthritis.
Endocrinology 1996;137(9):3729-37.
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1995: Ohba Y; Goto Y; Kimura Y; Suzuki F; Hisa T; Takahashi K; Takigawa M
Purification of an angiogenesis inhibitor from culture medium conditioned by a human chondrosarcoma-derived chondrocytic cell line, HCS-2/8.
Biochimica et biophysica acta 1995;1245(1):1-8.
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1994: Nakanishi T; Ohyama K; Aoki C; Kudo A; Hattori T; Takahashi K; Taniguchi S; Takigawa M
Expression of trkC in a mouse osteoblastic cell line and its response to neurotrophin-3.
Biochemical and biophysical research communications 1994;203(2):1268-74.
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