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Fusao Takusagawa

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Fusao Takusagawa
Microsomal prostaglandin E synthase type 2 (mPGES2) is a glutathione-dependent heme protein, and dithiothreitol dissociates the bound heme to produce active prostaglandin E2 synthase in vitro.
George D Markham; Fusao Takusagawa; Anthony M Dijulio; Charles W Bock
An investigation of the catalytic mechanism of S-adenosylmethionine synthetase by QM/MM calculations.
John C Taylor; Charles W Bock; Fusao Takusagawa; George D Markham
Discovery of novel types of inhibitors of S-adenosylmethionine synthesis by virtual screening.

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2013: Fusao Takusagawa
Microsomal prostaglandin E synthase type 2 (mPGES2) is a glutathione-dependent heme protein, and dithiothreitol dissociates the bound heme to produce active prostaglandin E2 synthase in vitro.
The Journal of biological chemistry 2013;288(14):10166-75.
2009: George D Markham; Fusao Takusagawa; Anthony M Dijulio; Charles W Bock
An investigation of the catalytic mechanism of S-adenosylmethionine synthetase by QM/MM calculations.
Archives of biochemistry and biophysics 2009;492(1-2):82-92.
2009: John C Taylor; Charles W Bock; Fusao Takusagawa; George D Markham
Discovery of novel types of inhibitors of S-adenosylmethionine synthesis by virtual screening.
Journal of medicinal chemistry 2009;52(19):5967-73.
2008: Tomoharu Gomi; Fusao Takusagawa; Mikio Nishizawa; Bukhari Agussalim; Isao Usui; Eiji Sugiyama; Hirofumi Taki; Kouichiro Shinoda; Hiroyuki Hounoki; Toshiro Miwa; Kazuyuki Tobe; Masashi Kobayashi; Tetsuya Ishimoto; Hirofumi Ogawa; Hisashi Mori
Cloning, bacterial expression, and unique structure of adenosylhomocysteine hydrolase-like protein 1, or inositol 1,4,5-triphosphate receptor-binding protein from mouse kidney.
Biochimica et biophysica acta 2008;1784(11):1786-94.
2008: Taro Yamada; Junichi Komoto; Tatsuo Kasuya; Yoshimi Takata; Hirofumi Ogawa; Hisashi Mori; Fusao Takusagawa
A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: crystal structure and site-directed mutagenesis studies.
Biochimica et biophysica acta 2008;1780(5):809-18.
2007: Taro Yamada; Fusao Takusagawa
PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme.
Biochemistry 2007;46(28):8414-24.
2007: Keitarou Saiki; Taro Yamada; Fusao Takusagawa; Kiyoshi Konishi
[Structure, function, and stability of cytolethal distending toxin].
Seikagaku. The Journal of Japanese Biochemical Society 2007;79(4):350-4.
2007: Taro Yamada; Junichi Komoto; Kaiyan Lou; Akiharu Ueki; Duy H Hua; Kimio Sugiyama; Yoshimi Takata; Hirofumi Ogawa; Fusao Takusagawa
Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents.
Biochemical pharmacology 2007;73(7):981-9.
2006: Hirofumi Ogawa; Tomoharu Gomi; Mikio Nishizawa; Yumiko Hayakawa; Shunro Endo; Kyoko Hayashi; Hiroshi Ochiai; Fusao Takusagawa; Henry C Pitot; Hisashi Mori; Hiroaki Sakurai; Keiichi Koizumi; Ikuo Saiki; Hirofumi Oda; Takashi Fujishita; Toshiro Miwa; Muneharu Maruyama; Masashi Kobayashi
Enzymatic and biochemical properties of a novel human serine dehydratase isoform.
Biochimica et biophysica acta 2006;1764(5):961-71.
2006: Junichi Komoto; Taro Yamada; Kikuko Watanabe; David F Woodward; Fusao Takusagawa
Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost.
Biochemistry 2006;45(7):1987-96.
2006: Taro Yamada; Junichi Komoto; Keitarou Saiki; Kiyoshi Konishi; Fusao Takusagawa
Variation of loop sequence alters stability of cytolethal distending toxin (CDT): crystal structure of CDT from Actinobacillus actinomycetemcomitans.
Protein science : a publication of the Protein Society 2006;15(2):362-72.
2005: Taro Yamada; Yoshimi Takata; Junichi Komoto; Tomoharu Gomi; Hirofumi Ogawa; Motoji Fujioka; Fusao Takusagawa
Catalytic mechanism of S-adenosylhomocysteine hydrolase: roles of His 54, Asp130, Glu155, Lys185, and Aspl89.
The international journal of biochemistry & cell biology 2005;37(11):2417-35.
2005: Taro Yamada; Junichi Komoto; Kikuko Watanabe; Yoshihiro Ohmiya; Fusao Takusagawa
Crystal structure and possible catalytic mechanism of microsomal prostaglandin E synthase type 2 (mPGES-2).
Journal of molecular biology 2005;348(5):1163-76.
2005: Tatsuhiko Kashii; Tomoharu Gomi; Takeshi Oya; Yoko Ishii; Hirofumi Oda; Muneharu Maruyama; Masashi Kobayashi; Tohru Masuda; Mitsuaki Yamazaki; Takuya Nagata; Kazuhiro Tsukada; Akinori Nakajima; Kazuhito Tatsu; Hisashi Mori; Fusao Takusagawa; Hirofumi Ogawa; Henry C Pitot
Some biochemical and histochemical properties of human liver serine dehydratase.
The international journal of biochemistry & cell biology 2005;37(3):574-89.
2004: Junichi Komoto; Taro Yamada; Yoshimi Takata; Kiyoshi Konishi; Hirofumi Ogawa; Tomoharu Gomi; Motoji Fujioka; Fusao Takusagawa
Catalytic mechanism of guanidinoacetate methyltransferase: crystal structures of guanidinoacetate methyltransferase ternary complexes.
Biochemistry 2004;43(45):14385-94.
2004: Junichi Komoto; Taro Yamada; Kikuko Watanabe; Fusao Takusagawa
Crystal structure of human prostaglandin F synthase (AKR1C3).
Biochemistry 2004;43(8):2188-98.
2004: Junichi Komoto; Taro Yamada; Yoshimi Takata; George D Markham; Fusao Takusagawa
Crystal structure of the S-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of S-adenosylmethionine synthesis from ATP and Met.
Biochemistry 2004;43(7):1821-31.
2003: Taro Yamada; Junichi Komoto; Yoshimi Takata; Hirofumi Ogawa; Henry C Pitot; Fusao Takusagawa
Crystal structure of serine dehydratase from rat liver.
Biochemistry 2003;42(44):12854-65.
2003: Junichi Komoto; Yoshimi Takata; Taro Yamada; Kiyoshi Konishi; Hirofumi Ogawa; Tomoharu Gomi; Motoji Fujioka; Fusao Takusagawa
Monoclinic guanidinoacetate methyltransferase and gadolinium ion-binding characteristics.
Acta crystallographica. Section D, Biological crystallography 2003;59(Pt 9):1589-96.
2003: Tohru Masuda; Hirofumi Ogawa; Takako Matsushima; Seiichi Kawamata; Masakiyo Sasahara; Kazunari Kuroda; Yasuhiro Suzuki; Yoshimi Takata; Mitsuaki Yamazaki; Fusao Takusagawa; Henry C Pitot
Localization and hormonal control of serine dehydratase during metabolic acidosis differ markedly from those of phosphoenolpyruvate carboxykinase in rat kidney.
The international journal of biochemistry & cell biology 2003;35(8):1234-47.
2003: Yoshimi Takata; Yafei Huang; Junichi Komoto; Taro Yamada; Kiyoshi Konishi; Hirofumi Ogawa; Tomoharu Gomi; Motoji Fujioka; Fusao Takusagawa
Catalytic mechanism of glycine N-methyltransferase.
Biochemistry 2003;42(28):8394-402.
2002: John C Taylor; Fusao Takusagawa; George D Markham
The active site loop of S-adenosylmethionine synthetase modulates catalytic efficiency.
Biochemistry 2002;41(30):9358-69.
2002: Junichi Komoto; Yafei Huang; Yoshimi Takata; Taro Yamada; Kiyoshi Konishi; Hirofumi Ogawa; Tomoharu Gomi; Motoji Fujioka; Fusao Takusagawa
Crystal structure of guanidinoacetate methyltransferase from rat liver: a model structure of protein arginine methyltransferase.
Journal of molecular biology 2002;320(2):223-35.
2002: Yoshimi Takata; Taro Yamada; Yafei Huang; Junichi Komoto; Tomoharu Gomi; Hirofumi Ogawa; Motoji Fujioka; Fusao Takusagawa
Catalytic mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
The Journal of biological chemistry 2002;277(25):22670-6.
2002: Hirofumi Ogawa; Tomoharu Gomi; Fusao Takusagawa; Toru Masuda; Takuya Goto; Takanobu Kan; Nam-ho Huh
Evidence for a dimeric structure of rat liver serine dehydratase.
The international journal of biochemistry & cell biology 2002;34(5):533-43.
2002: Yafei Huang; Junichi Komoto; Yoshimi Takata; Douglas R Powell; Tomoharu Gomi; Hirofumi Ogawa; Motoji Fujioka; Fusao Takusagawa
Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine.
The Journal of biological chemistry 2002;277(9):7477-82.
2001: Fusao Takusagawa; R G Carlson; Robert F Weaver
Anti-leukemia selectivity in actinomycin analogues.
Bioorganic & medicinal chemistry 2001;9(3):719-25.
2000: Junichi Komoto; Yafei Huang; Tomoharu Gomi; Hirofumi Ogawa; Yoshimi Takata; Motoji Fujioka; Fusao Takusagawa
Effects of site-directed mutagenesis on structure and function of recombinant rat liver S-adenosylhomocysteine hydrolase. Crystal structure of D244E mutant enzyme.
The Journal of biological chemistry 2000;275(41):32147-56.
2000: Hyae-Kyeong Kim; JY Nam; Mi Young Han; Kwang-Hee Son; Jung-Do Choi; Byoung-Mog Kwon; H L Takusagawa; Yafei Huang; Fusao Takusagawa
Natural and synthetic analogues of actinomycin D as Grb2-SH2 domain blockers.
Bioorganic & medicinal chemistry letters 2000;10(13):1455-7.
2000: Yafei Huang; Junichi Komoto; Kiyoshi Konishi; Yoshimi Takata; Hirofumi Ogawa; Tomoharu Gomi; Motoji Fujioka; Fusao Takusagawa
Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
Journal of molecular biology 2000;298(1):149-62.
2000: H L Takusagawa; Fusao Takusagawa
Crystallization and preliminary X-ray diffraction studies of d(ACGTAGCTACGT)2:[actinomycin D, (echinomycin)2] and d(ACGTAGCTACGT)2:[actinomycin D, (triostin A)2] complexes.
Acta crystallographica. Section D, Biological crystallography 2000;56(Pt 3):344-7.
1999: Junichi Komoto; Yafei Huang; Yongbo Hu; Yoshimi Takata; Kiyoshi Konishi; Hirofumi Ogawa; Tomoharu Gomi; Motoji Fujioka; Fusao Takusagawa
Crystallization and preliminary x-ray diffraction studies of guanidinoacetate methyltransferase from rat liver.
Acta crystallographica. Section D, Biological crystallography 1999;55(Pt 11):1928-9.
1999: Yongbo Hu; Junichi Komoto; Yafei Huang; Tomoharu Gomi; Hirofumi Ogawa; Yoshimi Takata; Motoji Fujioka; Fusao Takusagawa
Crystal structure of S-adenosylhomocysteine hydrolase from rat liver.
Biochemistry 1999;38(26):8323-33.
1999: Hirofumi Ogawa; Fusao Takusagawa; Kunihiko Wakaki; H Kishi; M R Eskandarian; Masashi Kobayashi; T Date; Nam-ho Huh; Henry C Pitot
Rat liver serine dehydratase. Bacterial expression and two folding domains as revealed by limited proteolysis.
The Journal of biological chemistry 1999;274(18):12855-60.
1998: Hirofumi Ogawa; Tomoharu Gomi; Fusao Takusagawa; Motoji Fujioka
Structure, function and physiological role of glycine N-methyltransferase.
The international journal of biochemistry & cell biology 1998;30(1):13-26.
1997: Fusao Takusagawa; K T Takusagawa; R G Carlson; Robert F Weaver
Selectivity of F8-actinomycin D for RNA:DNA hybrids and its anti-leukemia activity.
Bioorganic & medicinal chemistry 1997;5(6):1197-207.
1996: Fusao Takusagawa; L Wen; W Chu; Q Li; K T Takusagawa; R G Carlson; Robert F Weaver
Physical and biological characteristics of the antitumor drug actinomycin D analogues derivatized at N-methyl-L-valine residues.
Biochemistry 1996;35(40):13240-9.
1996: Z Fu; Yongbo Hu; K Konishi; Yoshimi Takata; Hirofumi Ogawa; Tomoharu Gomi; Motoji Fujioka; Fusao Takusagawa
Crystal structure of glycine N-methyltransferase from rat liver.
Biochemistry 1996;35(37):11985-93.
1996: Z Fu; Yongbo Hu; G D Markham; Fusao Takusagawa
Flexible loop in the structure of S-adenosylmethionine synthetase crystallized in the tetragonal modification.
Journal of biomolecular structure & dynamics 1996;13(5):727-39.
1996: Fusao Takusagawa; S Kamitori; G D Markham
Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry 1996;35(8):2586-96.
1996: Fusao Takusagawa; S Kamitori; S Misaki; G D Markham
Crystal structure of S-adenosylmethionine synthetase.
The Journal of biological chemistry 1996;271(1):136-47.
1995: M Shinomiya; W Chu; R G Carlson; Robert F Weaver; Fusao Takusagawa
Structural, physical, and biological characteristics of RNA.DNA binding agent N8-actinomycin D.
Biochemistry 1995;34(26):8481-91.
1994: Z Fu; Fusao Takusagawa; K Konishi; Yoshimi Takata; Motoji Fujioka
Crystallization and preliminary X-ray diffraction studies of glycine methyltransferase from rat liver.
Journal of structural biology 1994;113(3):247-9.
1993: Binghe Wang; Fusao Takusagawa; M P Mertes; K Bowman-James
Structure of the product from a novel cyclization reaction involving a C(6)-substituted uridine analog.
Acta crystallographica. Section C, Crystal structure communications 1993;49 ( Pt 9)():1568-71.
1993: S Kamitori; Fusao Takusagawa
[DNA intercalation; x-ray crystallographic studies].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 1993;38(6):957-70.
1993: C M Riley; D L Ross; David VanderVelde; Fusao Takusagawa
Characterization of the complexation of fluoroquinolone antimicrobials with metal ions by nuclear magnetic resonance spectroscopy.
Journal of pharmaceutical and biomedical analysis 1993;11(1):49-59.
1992: S Kamitori; Fusao Takusagawa
Crystal structure of the 2:1 complex between d(GAAGCTTC) and the anticancer drug actinomycin D.
Journal of molecular biology 1992;225(2):445-56.
1991: Gary L Grunewald; M S Palanki; Fusao Takusagawa
Structures of two conformationally defined phenylethanolamines: exo-1,4-epoxy-2-formamido-1,2,3,4-tetrahydro-8-trifluoromethylnaphthale ne and exo-1,4-epoxy-2-formamido-1,2,3,4-tetrahydro-6-trifluoromethylnaphthale ne.
Acta crystallographica. Section C, Crystal structure communications 1991;47 ( Pt 4)():771-5.
1990: Fusao Takusagawa
The crystal structure of d(GTACGTAC) at 2.25 A resolution: are the A-DNA's always unwound approximately 10 degrees at the C-G steps?
Journal of biomolecular structure & dynamics 1990;7(4):795-809.
1989: J Sakon; A Reiter; K B Mertes; Fusao Takusagawa
Structure of [N,N'-propylenebis(2-pyrrolylmethyleneaminato)]nickel(II).
Acta crystallographica. Section C, Crystal structure communications 1989;45 ( Pt 9)():1311-4.