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TT Talele

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Bhargav A Patel; Maulik R Patel; Payal Arora; Amartya Basu; Aaditya Bhatt; Dibyendu Dana; K R Gurukumar; Neerja Kaushik-Basu; Nikhil Khadtare; Ramalingam Krishnan; Sanjai Kumar; TT Talele
Design and synthesis of l- and d-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.
Daniel B Nichols; TT Talele; Raquel A C Leão; Amartya Basu; Maksim Chudayeu; Paulo R R Costa; Paula de F de Moraes; Neerja Kaushik-Basu
Evaluation of Coumarin and Neoflavone Derivatives as HCV NS5B Polymerase Inhibitors.
Esra Tatar; TT Talele; Dirk Daelemans; Erik De Clercq; Neerja Kaushik-Basu; Ilkay Küçükgüzel; Christophe Pannecouque
Some hydrazones of 2-aroylamino-3-methylbutanohydrazide: synthesis, molecular modeling studies, and identification as stereoselective inhibitors of HIV-1.

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All Publications

2013: Bhargav A Patel; Maulik R Patel; Payal Arora; Amartya Basu; Aaditya Bhatt; Dibyendu Dana; K R Gurukumar; Neerja Kaushik-Basu; Nikhil Khadtare; Ramalingam Krishnan; Sanjai Kumar; TT Talele
Design and synthesis of l- and d-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.
Bioorganic & medicinal chemistry 2013;21(11):3262-71.
2013: Daniel B Nichols; TT Talele; Raquel A C Leão; Amartya Basu; Maksim Chudayeu; Paulo R R Costa; Paula de F de Moraes; Neerja Kaushik-Basu
Evaluation of Coumarin and Neoflavone Derivatives as HCV NS5B Polymerase Inhibitors.
Chemical biology & drug design 2013;81(5):607-14.
2013: Esra Tatar; TT Talele; Dirk Daelemans; Erik De Clercq; Neerja Kaushik-Basu; Ilkay Küçükgüzel; Christophe Pannecouque
Some hydrazones of 2-aroylamino-3-methylbutanohydrazide: synthesis, molecular modeling studies, and identification as stereoselective inhibitors of HIV-1.
Archiv der Pharmazie 2013;346(2):140-53.
2013: Amit K Tiwari; Zhi-Jie Xiao; Alaa H. Abuznait; Chun-Ling Dai; Liwu Fu; James M Gallo; Amal Kaddoumi; Atish Patel; Satyakam Singh; Kamlesh Sodani; TT Talele; Zhe-Sheng Chen
Nilotinib potentiates anticancer drug sensitivity in murine ABCB1-, ABCG2-, and ABCC10-multidrug resistance xenograft models.
Cancer letters 2013;328(2):307-17.
2013: S Güniz Küçükgüzel; Özlem Bingöl Özakpınar; Derya Özsavcı; Azize Şener; Göknur Aktay; Sevil Aydın; Amartya Basu; İnci Coşkun; Neerja Kaushik-Basu; Özge Çevik; Şule Gürsoy; TT Talele
Synthesis and characterization of celecoxib derivatives as possible anti-inflammatory, analgesic, antioxidant, anticancer and anti-HCV agents.
Molecules (Basel, Switzerland) 2013;18(3):3595-614.
2013: Ke-Jun Liu; Hong-May Sim; Satyakam Singh; Kamlesh Sodani; Xiao-Dong Su; TT Talele; Fang Wang; Hai-Ying Wu; Jing-Dun Xie; Suresh V Ambudkar; Xing-Gui Chen; Zhe-Sheng Chen; Jie-Hua He; Yong-Ju Liang; Li-Wu Fu
Saracatinib (AZD0530) is a potent modulator of ABCB1-mediated multidrug resistance in vitro and in vivo.
International journal of cancer. Journal international du cancer 2013;132(1):224-35.
2012: Andriy G Golub; K R Gurukumar; Amartya Basu; Volodymyr G Bdzhola; Yaroslav Bilokin; Jin-Ching Lee; Daniel B Nichols; TT Talele; Sergiy M Yarmoluk; Neerja Kaushik-Basu
Discovery of new scaffolds for rational design of HCV NS5B polymerase inhibitors.
European journal of medicinal chemistry 2012;58():258-64.
2012: Kamlesh Sodani; Yue-Li Sun; TT Talele; Amit K. Tiwari; Zhi-Jie Xiao; Jun-Jiang Chen; Manoj Patel; Satyakam Singh; Zhe-Sheng Chen
GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance.
Biochemical pharmacology 2012;83(12):1613-22.
2012: Shridhar S Kulkarni; Woon-Kai Low; Janki R Shah; Satyakam Singh; TT Talele
Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors.
European journal of medicinal chemistry 2012;50():264-73.
2012: Maulik R Patel; Maria A Pino; Satyakam Singh; Blase Billack; Kurt Degenhardt; Cesar A Lau-Cam; Kashyap G Pandya; TT Talele
Design and synthesis of N-substituted indazole-3-carboxamides as poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors(†).
Chemical biology & drug design 2012;79(4):488-96.
2011: Aaditya Bhatt; K R Gurukumar; Neerja Kaushik-Basu; Maulik R Patel; Amartya Basu; TT Talele
Synthesis and SAR optimization of diketo acid pharmacophore for HCV NS5B polymerase inhibition.
European journal of medicinal chemistry 2011;46(10):5138-45.
2011: Nootan Pandey; TT Talele; Alok K Upadhyay; Thomas W Comollo; Neerja Kaushik-Basu; Dinesh Manvar; Chaturbhuj A Mishra; Virendra N Pandey
The glutamine side chain at position 91 on the β5a-β5b loop of human immunodeficiency virus type 1 reverse transcriptase is required for stabilizing the dNTP binding pocket.
Biochemistry 2011;50(37):8067-77.
2011: Aaditya Bhatt; Pallav D Patel; Maulik R Patel; Satyakam Singh; Cesar A Lau-Cam; TT Talele
CoMSIA study on substituted aryl alkanoic acid analogs as GPR40 agonists.
Chemical biology & drug design 2011;77(5):361-72.
2011: Zhi Shi; Amit K. Tiwari; Suneet Shukla; Robert W Robey; Satyakam Singh; In-Wha Kim; Susan E Bates; Xingxiang Peng; Ioana Abraham; Suresh V Ambudkar; TT Talele; Li-Wu Fu; Zhe-Sheng Chen
Sildenafil reverses ABCB1- and ABCG2-mediated chemotherapeutic drug resistance.
Cancer research 2011;71(8):3029-41.
2011: Pei-Rong Ding; Amit K. Tiwari; Shinobu Ohnuma; Jeferson W K K Lee; Xin An; Chun-Ling Dai; Qi-Si Lu; Satyakam Singh; Dong-Hua Yang; TT Talele; Suresh V Ambudkar; Zhe-Sheng Chen
The phosphodiesterase-5 inhibitor vardenafil is a potent inhibitor of ABCB1/P-glycoprotein transporter.
PloS one 2011;6(4):e19329.
2010: Diane Hardej; Charles R Ashby; Nikhil S Khadtare; Shridhar S Kulkarni; Satyakam Singh; TT Talele
The synthesis of phenylalanine-derived C5-substituted rhodanines and their activity against selected methicillin-resistant Staphylococcus aureus (MRSA) strains.
European journal of medicinal chemistry 2010;45(12):5827-32.
2010: TT Talele; Payal Arora; Shridhar S Kulkarni; Maulik R Patel; Satyakam Singh; Maksim Chudayeu; Neerja Kaushik-Basu
Structure-based virtual screening, synthesis and SAR of novel inhibitors of hepatitis C virus NS5B polymerase.
Bioorganic & medicinal chemistry 2010;18(13):4630-8.
2010: Pallav D Patel; Maulik R Patel; Bela Kocsis; Erika Kocsis; Steven M Graham; Andrew R Warren; Stacia M Nicholson; Blase Billack; Frank R Fronczek; TT Talele
Design, synthesis and determination of antifungal activity of 5(6)-substituted benzotriazoles.
European journal of medicinal chemistry 2010;45(6):2214-22.
2010: Alok K Upadhyay; TT Talele; Virendra N Pandey
Impact of template overhang-binding region of HIV-1 RT on the binding and orientation of the duplex region of the template-primer.
Molecular and cellular biochemistry 2010;338(1-2):19-33.
2010: Alok Upadhyay; Nootan Pandey; Chaturbhuj A Mishra; TT Talele; Virendra N Pandey
A single deletion at position 134, 135, or 136 in the beta 7-beta 8 loop of the p51 subunit of HIV-1 RT disrupts the formation of heterodimeric enzyme.
Journal of cellular biochemistry 2010;109(3):598-605.
2010: TT Talele; Santosh A Khedkar; Alan C Rigby
Successful applications of computer aided drug discovery: moving drugs from concept to the clinic.
Current topics in medicinal chemistry 2010;10(1):127-41.
2009: TT Talele; Alok Upadhyay; Virendra N Pandey
Influence of the RNase H domain of retroviral reverse transcriptases on the metal specificity and substrate selection of their polymerase domains.
Virology journal 2009;6():159.
2009: Ye Chen; Alain Bopda-Waffo; Amartya Basu; Ramalingam Krishnan; Erica Silberstein; Deborah R Taylor; TT Talele; Payal Arora; Neerja Kaushik-Basu
Characterization of aurintricarboxylic acid as a potent hepatitis C virus replicase inhibitor.
Antiviral chemistry & chemotherapy 2009;20(1):19-36.
2009: Kirandeep Kaur; TT Talele
Structure-based CoMFA and CoMSIA study of indolinone inhibitors of PDK1.
Journal of computer-aided molecular design 2009;23(1):25-36.
2008: Kirandeep Kaur; TT Talele
3D QSAR studies of 1,3,4-benzotriazepine derivatives as CCK2 receptor antagonists.
Journal of molecular graphics & modelling 2008;27(4):409-20.
2008: TT Talele; Mark L McLaughlin
Molecular docking/dynamics studies of Aurora A kinase inhibitors.
Journal of molecular graphics & modelling 2008;26(8):1213-22.
2008: Shridhar S Kulkarni; Maulik R Patel; TT Talele
CoMFA and HQSAR studies on 6,7-dimethoxy-4-pyrrolidylquinazoline derivatives as phosphodiesterase10A inhibitors.
Bioorganic & medicinal chemistry 2008;16(7):3675-86.
2008: Neerja Kaushik-Basu; Alain Bopda-Waffo; TT Talele; Amartya Basu; Paulo R R Costa; Antônio J R da Silva; Stefan G Sarafianos; François Noël
Identification and characterization of coumestans as novel HCV NS5B polymerase inhibitors.
Nucleic acids research 2008;36(5):1482-96.
2008: Neerja Kaushik-Basu; Alain Bopda-Waffo; TT Talele; Amartya Basu; Ye Chen; S Guniz Kucukguzel
4-Thiazolidinones: a novel class of hepatitis C virus NS5B polymerase inhibitors.
Frontiers in bioscience : a journal and virtual library 2008;13():3857-68.
2008: Pallav D Patel; Maulik R Patel; Neerja Kaushik-Basu; TT Talele
3D QSAR and molecular docking studies of benzimidazole derivatives as hepatitis C virus NS5B polymerase inhibitors.
Journal of chemical information and modeling 2008;48(1):42-55.
2001: Neerja Kaushik; TT Talele; R Monel; Paul Palumbo; Virendra N Pandey
Destabilization of tRNA3(Lys) from the primer-binding site of HIV-1 genome by anti-A loop polyamide nucleotide analog.
Nucleic acids research 2001;29(24):5099-106.
2001: Pradeep K Pandey; Neerja Kaushik; TT Talele; PN Yadav; Virendra N Pandey
Insertion of a peptide from MuLV RT into the connection subdomain of HIV-1 RT results in a functionally active chimeric enzyme in monomeric conformation.
Molecular and cellular biochemistry 2001;225(1-):135-44.
2001: Pradeep K Pandey; Neerja Kaushik; TT Talele; PN Yadav; Virendra N Pandey
The beta7-beta8 loop of the p51 subunit in the heterodimeric (p66/p51) human immunodeficiency virus type 1 reverse transcriptase is essential for the catalytic function of the p66 subunit.
Biochemistry 2001;40(32):9505-12.
2000: Neerja Kaushik; TT Talele; Pradeep K Pandey; Dylan Harris; PN Yadav; Virendra N Pandey
Role of glutamine 151 of human immunodeficiency virus type-1 reverse transcriptase in substrate selection as assessed by site-directed mutagenesis.
Biochemistry 2000;39(11):2912-20.