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Steve Tam
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Research Profile (preview)
Concepts & Ideas
Chemicals & Drugs
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Procedures
Physiology
Phenomena
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Network (preview)
8
Clark, James
8
Hu, Yonghan
7
McKew, John
6
Nickerson-Nutter, Cheryl
6
Shen, Marina
6
Kaila, Neelu
6
Chen, Lihren
5
Janz, Kristin
5
Xu, Xin
4
Keith, James
4
Kirincich, Steven
4
Camphausen, Raymond
4
Ipek, Manus
4
Green, Neal
4
Bedard, Patricia
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Publications
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Geonetwork of Steve Tam (preview)
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All Publications
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2009: Li Wei; Hu Yonghan; Li Jianchang; Thomason Jennifer R; DeVincentis Dianne; Du Xuemei; Wu Junjun; Hotchandani Rajeev; Rush Thomas S; Skotnicki Jerauld S; Tam Steve; Chockalingam Priya S; Morris Elisabeth A; Levin Jeremy I
3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding.
Bioorganic & medicinal chemistry letters 2009;19(16):4546-50.
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2009: Kirincich Steven J; Xiang Jason; Green Neal; Tam Steve; Yang Hui Y; Shim Jaechul; Shen Marina W H; Clark James D; McKew John C
Benzhydrylquinazolinediones: novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical properties.
Bioorganic & medicinal chemistry 2009;17(13):4383-405.
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2009: Chen Lihren; Wang Weiheng; Lee Katherine L; Shen Marina W H; Murphy Elizabeth A; Zhang Wen; Xu Xin; Tam Steve; Nickerson-Nutter Cheryl; Goodwin Debra G; Clark James D; McKew John C
Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors.
Journal of medicinal chemistry 2009;52(4):1156-71.
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2008: McKew John C; Lee Katherine L; Shen Marina W H; Thakker Paresh; Foley Megan A; Behnke Mark L; Hu Baihua; Sum Fuk-Wah; Tam Steve; Hu Yonghan; Chen Lihren; Kirincich Steven J; Michalak Ronald; Thomason Jennifer; Ipek Manus; Wu Kun; Wooder Lane; Ramarao Manjunath K; Murphy Elizabeth A; Goodwin Debra G; Albert Leo; Xu Xin; Donahue Frances; Ku M Sherry; Keith James; Nickerson-Nutter Cheryl L; Abraham William M; Williams Cara; Hegen Martin; Clark James D
Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.
Journal of medicinal chemistry 2008;51(12):3388-413.
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2008: Lee Katherine L; Behnke Mark L; Foley Megan A; Chen Lihren; Wang Weiheng; Vargas Richard; Nunez Jill; Tam Steve; Mollova Nevena; Xu Xin; Shen Marina W H; Ramarao Manjunath K; Goodwin Debra G; Nickerson-Nutter Cheryl L; Abraham William M; Williams Cara; Clark James D; McKew John C
Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.
Bioorganic & medicinal chemistry 2008;16(3):1345-58.
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2007: Hall J Perry; Kurdi Yahya; Hsu Sang; Cuozzo John; Liu Julie; Telliez Jean-Baptiste; Seidl Katherine J; Winkler Aaron; Hu Yonghan; Green Neal; Askew G Roger; Tam Steve; Clark James D; Lin Lih-Ling
Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
The Journal of biological chemistry 2007;282(46):33295-304.
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2007: Kaila Neelu; Green Neal; Li Huan-Qiu; Hu Yonghan; Janz Kristin; Gavrin Lori Krim; Thomason Jennifer; Tam Steve; Powell Dennis; Cuozzo John; Hall J Perry; Telliez Jean-Baptiste; Hsu Sang; Nickerson-Nutter Cheryl; Wang Qin; Lin Lih-Ling
Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.
Bioorganic & medicinal chemistry 2007;15(19):6425-42.
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2007: Wan Zhao-Kui; Follows Bruce; Kirincich Steve; Wilson Douglas; Binnun Eva; Xu Weixin; Joseph-McCarthy Diane; Wu Junjun; Smith Michael; Zhang Yan-Ling; Tam May; Erbe David; Tam Steve; Saiah Eddine; Lee Jinbo
Probing acid replacements of thiophene PTP1B inhibitors.
Bioorganic & medicinal chemistry letters 2007;17(10):2913-20.
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2007: Lee Katherine L; Foley Megan A; Chen Lihren; Behnke Mark L; Lovering Frank E; Kirincich Steven J; Wang Weiheng; Shim Jaechul; Tam Steve; Shen Marina W H; Khor Soopeang; Xu Xin; Goodwin Debra G; Ramarao Manjunath K; Nickerson-Nutter Cheryl; Donahue Frances; Ku M Sherry; Clark James D; McKew John C
Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.
Journal of medicinal chemistry 2007;50(6):1380-400.
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2007: Kaila Neelu; Janz Kristin; Huang Adrian; Moretto Alessandro; DeBernardo Silvano; Bedard Patricia W; Tam Steve; Clerin Valerie; Keith James C; Tsao Desirée H H; Sushkova Natalia; Shaw Gray D; Camphausen Raymond T; Schaub Robert G; Wang Qin
2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.
Journal of medicinal chemistry 2007;50(1):40-64.
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2007: Kaila Neelu; Janz Kristin; DeBernardo Silvano; Bedard Patricia W; Camphausen Raymond T; Tam Steve; Tsao Desirée H H; Keith James C; Nickerson-Nutter Cheryl; Shilling Adam; Young-Sciame Ruth; Wang Qin
Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.
Journal of medicinal chemistry 2007;50(1):21-39.
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2006: Hu Yonghan; Green Neal; Gavrin Lori K; Janz Kristin; Kaila Neelu; Li Huan-Qiu; Thomason Jennifer R; Cuozzo John W; Hall J Perry; Hsu Sang; Nickerson-Nutter Cheryl; Telliez Jean-Baptiste; Lin Lih-Ling; Tam Steve
Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.
Bioorganic & medicinal chemistry letters 2006;16(23):6067-72.
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2006: Gopalsamy Ariamala; Yang Hui; Ellingboe John W; McKew John C; Tam Steve; Joseph-McCarthy Diane; Zhang Wen; Shen Marina; Clark James D
1,2,4-Oxadiazolidin-3,5-diones and 1,3,5-triazin-2,4,6-triones as cytosolic phospholipase A2alpha inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(11):2978-81.
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2006: McKew John C; Foley Megan A; Thakker Paresh; Behnke Mark L; Lovering Frank E; Sum Fuk-Wah; Tam Steve; Wu Kun; Shen Marina W H; Zhang Wen; Gonzalez Mario; Liu Shanghao; Mahadevan Anu; Sard Howard; Khor Soo Peang; Clark James D
Inhibition of cytosolic phospholipase A2alpha: hit to lead optimization.
Journal of medicinal chemistry 2006;49(1):135-58.
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2006: Xiang Jason S; Hu Yonghan; Rush Thomas S; Thomason Jennifer R; Ipek Manus; Sum Phaik-Eng; Abrous Leila; Sabatini Joshua J; Georgiadis Katy; Reifenberg Erica; Majumdar Manas; Morris Elisabeth A; Tam Steve
Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.
Bioorganic & medicinal chemistry letters 2006;16(2):311-6.
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2005: Hu Yonghan; Xiang Jason S; DiGrandi Martin J; Du Xuemei; Ipek Manus; Laakso Leif M; Li Jianchang; Li Wei; Rush Thomas S; Schmid Jean; Skotnicki Jerauld S; Tam Steve; Thomason Jennifer R; Wang Qin; Levin Jeremy I
Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Bioorganic & medicinal chemistry 2005;13(24):6629-44.
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2005: Li Jianchang; Rush Thomas S; Li Wei; DeVincentis Dianne; Du Xuemei; Hu Yonghan; Thomason Jennifer R; Xiang Jason S; Skotnicki Jerauld S; Tam Steve; Cunningham Kristina M; Chockalingam Priya S; Morris Elisabeth A; Levin Jeremy I
Synthesis and SAR of highly selective MMP-13 inhibitors.
Bioorganic & medicinal chemistry letters 2005;15(22):4961-6.
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2005: Kaila Neelu; Somers William S; Thomas Bert E; Thakker Paresh; Janz Kristin; DeBernardo Silvano; Tam Steve; Moore William J; Yang Ruiyang; Wrona Wojciech; Bedard Patricia W; Crommie Deidre; Keith James C; Tsao Desiree H H; Alvarez Juan C; Ni Heyu; Marchese Erik; Patton John T; Magnani John L; Camphausen Raymond T
Quinic acid derivatives as sialyl Lewis(x)-mimicking selectin inhibitors: design, synthesis, and crystal structure in complex with E-selectin.
Journal of medicinal chemistry 2005;48(13):4346-57.
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2005: Xiang Jason; Ipek Manus; Suri Vipin; Massefski Walt; Pan Ning; Ge Ying; Tam May; Xing Yuzhe; Tobin James F; Xu Xin; Tam Steve
Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Bioorganic & medicinal chemistry letters 2005;15(11):2865-9.
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2003: Green Neal J; Xiang Jason; Chen Jing; Chen Lihren; Davies Audrey M; Erbe Dave; Tam Steve; Tobin James F
Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1.
Bioorganic & medicinal chemistry 2003;11(13):2991-3013.
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2002: Tobin James F; Tam Steve
Recent advances in the development of small molecule inhibitors of PTP1B for the treatment of insulin resistance and type 2 diabetes.
Current opinion in drug discovery & development 2002;5(4):500-12.
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2002: Kaila Neelu; Chen Lihren; Thomas Bert E; Tsao Desiree; Tam Steve; Bedard Patricia W; Camphausen Raymond T; Alvarez Juan C; Ullas Giliyar
Beta-C-mannosides as selectin inhibitors.
Journal of medicinal chemistry 2002;45(8):1563-6.
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