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Luca Tamagnone

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Michael Rehman; Luca Tamagnone
Semaphorins in cancer: biological mechanisms and therapeutic approaches.
Sabrina Rizzolio; Guido Serini; Letizia Lanzetti; Gera Neufeld; Jim Norman; Noa Rabinowicz; Elena Rainero; Luca Tamagnone
Neuropilin-1-dependent regulation of EGF-receptor signaling.
Luca Tamagnone
Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer.

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All Publications

2013: Michael Rehman; Luca Tamagnone
Semaphorins in cancer: biological mechanisms and therapeutic approaches.
Seminars in cell & developmental biology 2013;24(3):179-89.
2012: Sabrina Rizzolio; Guido Serini; Letizia Lanzetti; Gera Neufeld; Jim Norman; Noa Rabinowicz; Elena Rainero; Luca Tamagnone
Neuropilin-1-dependent regulation of EGF-receptor signaling.
Cancer research 2012;72(22):5801-11.
2012: Luca Tamagnone
Emerging role of semaphorins as major regulatory signals and potential therapeutic targets in cancer.
Cancer cell 2012;22(2):145-52.
2012: Andrea Casazza; Enrico Giraudo; Ofra Kessler; Boaz Kigel; Federica Maione; Massimiliano Mazzone; Gera Neufeld; Lorena Capparuccia; Luca Tamagnone
Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform.
EMBO molecular medicine 2012;4(3):234-50.
2012: Claudia Muratori; Luca Tamagnone
Semaphorin signals tweaking the tumor microenvironment.
Advances in cancer research 2012;114():59-85.
2011: Luca Tamagnone; Massimiliano Mazzone
Semaphorin signals on the road of endothelial tip cells.
Developmental cell 2011;21(2):189-90.
2011: Andrea Casazza; Xi Fu; Irja Johansson; Lorena Capparuccia; Fredrik Andersson; Alice Giustacchini; Mario Leonardo Squadrito; Mary Anna Venneri; Massimiliano Mazzone; Erik Larsson; Peter Carmeliet; Michele De Palma; Luigi Naldini; Luca Tamagnone; Charlotte Rolny
Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models.
Arteriosclerosis, thrombosis, and vascular biology 2011;31(4):741-9.
2011: Nina Perälä; Madis Jakobson; Roxana Ola; Pietro Fazzari; Junia Y Penachioni; Mariann Nymark; Tiina Tanninen; Tiina Immonen; Luca Tamagnone; Hannu Sariola
Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney.
Differentiation; research in biological diversity 2011;81(2):81-91.
2011: S Rizzolio; Luca Tamagnone
Multifaceted role of neuropilins in cancer.
Current medicinal chemistry 2011;18(23):3563-75.
2010: Mélanie Franco; Claudia Muratori; Simona Corso; Enrico Tenaglia; Andrea Bertotti; Lorena Capparuccia; livio trusolino; Paolo M Comoglio; Luca Tamagnone
The tetraspanin CD151 is required for Met-dependent signaling and tumor cell growth.
The Journal of biological chemistry 2010;285(50):38756-64.
2010: Andrea Casazza; Veronica Finisguerra; Lorena Capparuccia; Andrea Camperi; Jakub M Swiercz; Sabrina Rizzolio; Charlotte Rolny; Claus Christensen; Andrea Bertotti; Ivana Sarotto; Mauro Risio; livio trusolino; Jurgen Weitz; Martin Schneider; Massimiliano Mazzone; Paolo M Comoglio; Massimilano Mazzone; Luca Tamagnone
Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice.
The Journal of clinical investigation 2010;120(8):2684-98.
2009: Yufeng Tong; Prasanta K Hota; Junia Y Penachioni; MB Hamaneh; Soonjeung Kim; Rebecca S Alviani; Limin Shen; Hao He; Wolfram Tempel; Luca Tamagnone; Hee-Won Park; Matthias Buck
Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.
The Journal of biological chemistry 2009;284(51):35962-72.
2009: Simona Foscarin; Sara Gianola; Daniela Carulli; Pietro Fazzari; Sha Mi; Luca Tamagnone; Ferdinando Rossi
Overexpression of GAP-43 modifies the distribution of the receptors for myelin-associated growth-inhibitory proteins in injured Purkinje axons.
The European journal of neuroscience 2009;30(10):1837-48.
2009: Peter Vodrazka; Alexander Korostylev; Alexandra Hirschberg; Jakub M Swiercz; Thomas Worzfeld; Suhua Deng; Pietro Fazzari; Luca Tamagnone; Stefan Offermanns; Rohini Kuner
The semaphorin 4D-plexin-B signalling complex regulates dendritic and axonal complexity in developing neurons via diverse pathways.
The European journal of neuroscience 2009;30(7):1193-208.
2009: Asha Balakrishnan; Junia Y Penachioni; Simona Lamba; Fonnet E Bleeker; Carlo Zanon; Monica Rodolfo; Viviana Vallacchi; Aldo Scarpa; Lara Felicioni; Matthias Buck; Antonio Marchetti; Paolo M Comoglio; Alberto Bardelli; Luca Tamagnone
Molecular profiling of the "plexinome" in melanoma and pancreatic cancer.
Human mutation 2009;30(8):1167-74.
2009: Lorena Capparuccia; Luca Tamagnone
Semaphorin signaling in cancer cells and in cells of the tumor microenvironment--two sides of a coin.
Journal of cell science 2009;122(Pt 11):1723-36.
2009: Guido Valente; Giuseppina Nicotra; Marisa Arrondini; Roberta Castino; Lorena Capparuccia; Maria Prat; Simonetta Kerim; Luca Tamagnone; Ciro Isidoro
Co-expression of plexin-B1 and Met in human breast and ovary tumours enhances the risk of progression.
Cellular oncology : the official journal of the International Society for Cellular Oncology 2009;31(6):423-36.
2008: Paolo Giacobini; Andrea Messina; Francesca Morello; Nicoletta Ferraris; Simona Corso; Junia Penachioni; silvia giordano; Luca Tamagnone; Aldo Fasolo
Semaphorin 4D regulates gonadotropin hormone-releasing hormone-1 neuronal migration through PlexinB1-Met complex.
The Journal of cell biology 2008;183(3):555-66.
2008: Mélanie Franco; Luca Tamagnone
Tyrosine phosphorylation in semaphorin signalling: shifting into overdrive.
EMBO reports 2008;9(9):865-71.
2008: Jose Rafael Sierra; Simona Corso; Luisa Caione; Virna Cepero; Paolo Conrotto; Alessandro Cignetti; Wanda Piacibello; Atsushi Kumanogoh; Hitoshi Kikutani; paolo comoglio; Luca Tamagnone; silvia giordano
Tumor angiogenesis and progression are enhanced by Sema4D produced by tumor-associated macrophages.
The Journal of experimental medicine 2008;205(7):1673-85.
2008: Charlotte Rolny; Lorena Capparuccia; Andrea Casazza; Massimiliano Mazzone; Antonella Vallario; Alessandro Cignetti; Enzo Medico; Peter Carmeliet; paolo comoglio; Luca Tamagnone
The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment.
The Journal of experimental medicine 2008;205(5):1155-71.
2008: Simona Moretti; antonio procopio; Raffaella Lazzarini; Maria Rita Rippo; Roberto Testa; Maurizio Marra; Luca Tamagnone; Alfonso Catalano
Semaphorin3A signaling controls Fas (CD95)-mediated apoptosis by promoting Fas translocation into lipid rafts.
Blood 2008;111(4):2290-9.
2007: Suhua Deng; Alexandra Hirschberg; Thomas Worzfeld; Junia Y Penachioni; Alexander Korostylev; Jakub M Swiercz; Peter Vodrazka; Olivier Mauti; Esther T Stoeckli; Luca Tamagnone; Stefan Offermanns; Rohini Kuner
Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2007;27(23):6333-47.
2007: Sabrina Rizzolio; Luca Tamagnone
Semaphorin signals on the road to cancer invasion and metastasis.
Cell adhesion & migration 2007;1(2):62-8.
2007: Li Zhu; Wolfgang Bergmeier; Jie Wu; Hong Jiang; Timothy J Stalker; Marcin Cieslak; Ran Fan; Laurence Boumsell; Atsushi Kumanogoh; Hitoshi Kikutani; Luca Tamagnone; Denisa D Wagner; Marcos E Milla; Lawrence F Brass
Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(5):1621-6.
2007: Andrea Casazza; Pietro Fazzari; Luca Tamagnone
Semaphorin signals in cell adhesion and cell migration: functional role and molecular mechanisms.
Advances in experimental medicine and biology 2007;600():90-108.
2007: Pietro Fazzari; Junia Penachioni; Sara Gianola; Ferdinando Rossi; Britta J Eickholt; Flavio Maina; Lena Alexopoulou; Antonino Sottile; paolo comoglio; Richard A Flavell; Luca Tamagnone
Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis.
BMC developmental biology 2007;7():55.
2006: Terhi Kärpänen; Caroline A Heckman; Salla Keskitalo; Michael Jeltsch; Hanna Ollila; Gera Neufeld; Luca Tamagnone; Kari Alitalo
Functional interaction of VEGF-C and VEGF-D with neuropilin receptors.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2006;20(9):1462-72.
2006: Luca Tamagnone; silvia giordano
Semaphorin pathways orchestrate osteogenesis.
Nature cell biology 2006;8(6):545-7.
2006: Alfonso Catalano; Paola Caprari; Simona Moretti; Monica Faronato; Luca Tamagnone; antonio procopio
Semaphorin-3A is expressed by tumor cells and alters T-cell signal transduction and function.
Blood 2006;107(8):3321-9.
2005: Davide Barberis; Andrea Casazza; Raffaella Sordella; Simona Corso; Stefania Artigiani; Jeffrey Settleman; paolo comoglio; Luca Tamagnone
p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling.
Journal of cell science 2005;118(Pt 20):4689-700.
2005: Claus Christensen; Noona Ambartsumian; Giorgio F Gilestro; Birthe Thomsen; paolo comoglio; Luca Tamagnone; Per Guldberg; Eugene Lukanidin
Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis.
Cancer research 2005;65(14):6167-77.
2005: Paolo Conrotto; Donatella Valdembri; Simona Corso; Guido Serini; Luca Tamagnone; paolo comoglio; Federico Bussolino; silvia giordano
Sema4D induces angiogenesis through Met recruitment by Plexin B1.
Blood 2005;105(11):4321-9.
2005: Silvia Deaglio; Tiziana Vaisitti; Luciana Bergui; Lisa Bonello; Alberto L Horenstein; Luca Tamagnone; Laurence Boumsell; Fabio Malavasi
CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival.
Blood 2005;105(8):3042-50.
2005: Isabelle Chabbert-de Ponnat; Anne Marie-Cardine; R Jeroen Pasterkamp; Valérie Schiavon; Luca Tamagnone; Nicole Thomasset; Armand Bensussan; Laurence Boumsell
Soluble CD100 functions on human monocytes and immature dendritic cells require plexin C1 and plexin B1, respectively.
International immunology 2005;17(4):439-47.
2004: paolo comoglio; Luca Tamagnone; Silvia Giordano
Invasive growth: a two-way street for semaphorin signalling.
Nature cell biology 2004;6(12):1155-7.
2004: Daniela Marzioni; Luca Tamagnone; Lorena Capparuccia; Cristina Marchini; Augusto Amici; Tullia Todros; Paul Bischof; Sybille Neidhart; Gabriele Grenningloh; Mario Castellucci
Restricted innervation of uterus and placenta during pregnancy: evidence for a role of the repelling signal Semaphorin 3A.
Developmental dynamics : an official publication of the American Association of Anatomists 2004;231(4):839-48.
2004: Stefania Artigiani; Paolo Conrotto; Pietro Fazzari; Giorgio F Gilestro; Davide Barberis; silvia giordano; paolo comoglio; Luca Tamagnone
Plexin-B3 is a functional receptor for semaphorin 5A.
EMBO reports 2004;5(7):710-4.
2004: Luca Tamagnone; paolo comoglio
To move or not to move? Semaphorin signalling in cell migration.
EMBO reports 2004;5(4):356-61.
2004: Davide Barberis; Stefania Artigiani; Andrea Casazza; Simona Corso; silvia giordano; C A Love; E Y Jones; paolo comoglio; Luca Tamagnone
Plexin signaling hampers integrin-based adhesion, leading to Rho-kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(3):592-4.
2004: Alfonso Catalano; Paola Caprari; Sabrina Rodilossi; Pier Giacomo Betta; Mario Castellucci; Andrea Casazza; Luca Tamagnone; antonio procopio
Cross-talk between vascular endothelial growth factor and semaphorin-3A pathway in the regulation of normal and malignant mesothelial cell proliferation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2004;18(2):358-60.
2003: Guido Serini; Donatella Valdembri; Sara Zanivan; Giulia Morterra; Constanze Burkhardt; Francesca Caccavari; Luca Zammataro; Luca Primo; Luca Tamagnone; Malcolm Logan; Marc Tessier-Lavigne; Masahiko Taniguchi; Andreas W Püschel; Federico Bussolino
Class 3 semaphorins control vascular morphogenesis by inhibiting integrin function.
Nature 2003;424(6947):391-7.
2003: Stefania Artigiani; Davide Barberis; Pietro Fazzari; Paola Longati; Paola Angelini; Jan-Willem van de Loo; paolo comoglio; Luca Tamagnone
Functional regulation of semaphorin receptors by proprotein convertases.
The Journal of biological chemistry 2003;278(12):10094-101.
2002: silvia giordano; Simona Corso; Paolo Conrotto; Stefania Artigiani; Giorgio F Gilestro; Davide Barberis; Luca Tamagnone; paolo comoglio
The semaphorin 4D receptor controls invasive growth by coupling with Met.
Nature cell biology 2002;4(9):720-4.
2001: ML Winberg; Luca Tamagnone; J Bai; paolo comoglio; Denise Montell; Corey S Goodman
The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidance.
Neuron 2001;32(1):53-62.
2000: Luca Tamagnone; paolo comoglio
Signalling by semaphorin receptors: cell guidance and beyond.
Trends in cell biology 2000;10(9):377-83.
1999: paolo comoglio; Luca Tamagnone; Carla Boccaccio
Plasminogen-related growth factor and semaphorin receptors: a gene superfamily controlling invasive growth.
Experimental cell research 1999;253(1):88-99.
1999: Stefania Artigiani; paolo comoglio; Luca Tamagnone
Plexins, semaphorins, and scatter factor receptors: a common root for cell guidance signals?
IUBMB life 1999;48(5):477-82.
1999: Luca Tamagnone; Stefania Artigiani; H Chen; Z He; Guo-Li Ming; Hongjun Song; A Chedotal; ML Winberg; Corey S Goodman; M Poo; Marc Tessier-Lavigne; paolo comoglio
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.
Cell 1999;99(1):71-80.
1999: Paolo Michieli; Cristina Basilico; Selma Pennacchietti; A Maffè; Luca Tamagnone; silvia giordano; Alberto Bardelli; paolo comoglio
Mutant Met-mediated transformation is ligand-dependent and can be inhibited by HGF antagonists.
Oncogene 1999;18(37):5221-31.
1998: ML Winberg; Jasprina N Noordermeer; Luca Tamagnone; paolo comoglio; M K Spriggs; Marc Tessier-Lavigne; Corey S Goodman
Plexin A is a neuronal semaphorin receptor that controls axon guidance.
Cell 1998;95(7):903-16.
1998: Alberto Bardelli; Paola Longati; Daniela Gramaglia; Cristina Basilico; Luca Tamagnone; silvia giordano; D Ballinari; Paolo Michieli; paolo comoglio
Uncoupling signal transducers from oncogenic MET mutants abrogates cell transformation and inhibits invasive growth.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(24):14379-83.
1998: Carla Boccaccio; M Andò; Luca Tamagnone; Alberto Bardelli; Paolo Michieli; C Battistini; paolo comoglio
Induction of epithelial tubules by growth factor HGF depends on the STAT pathway.
Nature 1998;391(6664):285-8.
1997: Luca Tamagnone; paolo comoglio
Control of invasive growth by hepatocyte growth factor (HGF) and related scatter factors.
Cytokine & growth factor reviews 1997;8(2):129-42.
1996: E Maestrini; Luca Tamagnone; Paola Longati; O Cremona; Massimo Gulisano; Silvia Bione; F Tamanini; B G Neel; Daniela Toniolo; paolo comoglio
A family of transmembrane proteins with homology to the MET-hepatocyte growth factor receptor.
Proceedings of the National Academy of Sciences of the United States of America 1996;93(2):674-8.
1994: Elisa Vigna; L Naldini; Luca Tamagnone; Paola Longati; Alberto Bardelli; Flavio Maina; Carola Ponzetto; paolo comoglio
Hepatocyte growth factor and its receptor, the tyrosine kinase encoded by the c-MET proto-oncogene.
Cellular and molecular biology (Noisy-le-Grand, France) 1994;40(5):597-604.
1992: L Naldini; Luca Tamagnone; Elisa Vigna; Martin Sachs; Guido Hartmann; Walter Birchmeier; Y Daikuhara; H Tsubouchi; F Blasi; paolo comoglio
Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor.
The EMBO journal 1992;11(13):4825-33.
1992: Federico Bussolino; Maria Flavia Di Renzo; Marina Ziche; E Bocchietto; Martina Olivero; L Naldini; Giovanni Gaudino; Luca Tamagnone; A Coffer; paolo comoglio
Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth.
The Journal of cell biology 1992;119(3):629-41.
1988: silvia giordano; Maria Flavia Di Renzo; R P Narsimhan; Luca Tamagnone; E V Gerbaudo; L Chiadó-Piat; paolo comoglio
Evidence for autocrine activation of a tyrosine kinase in a human gastric carcinoma cell line.
Journal of cellular biochemistry 1988;38(4):229-36.