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Ikumi Tamai

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TOP 3
Yang Lu; Takeo Nakanishi; Ikumi Tamai
Functional Cooperation of SMCTs and URAT1 for Renal Reabsorption Transport of Urate.
Norikazu Matsunaga; Ken-ichi Nunoya; Mikio Ogawa; Masahiro Okada; Ikumi Tamai
Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
Yoshiyuki Shirasaka; Takanori Mori; Yukiko Murata; Takeo Nakanishi; Megumi Shichiri; Ikumi Tamai
Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption.

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All Publications

2013: Yang Lu; Takeo Nakanishi; Ikumi Tamai
Functional Cooperation of SMCTs and URAT1 for Renal Reabsorption Transport of Urate.
Drug metabolism and pharmacokinetics 2013;28(2):153-8.
2013: Norikazu Matsunaga; Ken-ichi Nunoya; Mikio Ogawa; Masahiro Okada; Ikumi Tamai
Evaluation of hepatic disposition of paroxetine using sandwich-cultured rat and human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(4):735-43.
2013: Yoshiyuki Shirasaka; Takanori Mori; Yukiko Murata; Takeo Nakanishi; Megumi Shichiri; Ikumi Tamai
Long-lasting inhibitory effect of apple and orange juices, but not grapefruit juice, on OATP2B1-mediated drug absorption.
Drug metabolism and disposition: the biological fate of chemicals 2013;41(3):615-21.
2013: Yoshiyuki Shirasaka; Kazuyuki Hayashi; Taku Kasai; Takeo Nakanishi; Akio Nishiura; Yasuhiro Ohno; Megumi Shichiri; Ikumi Tamai
A role of prostaglandin transporter in regulating PGE2 release from human bronchial epithelial BEAS-2B cells in response to LPS.
The Journal of endocrinology 2013;217(3):265-74.
2013: Yoshiyuki Shirasaka; Takanori Mori; Takeo Nakanishi; Megumi Shichiri; Ikumi Tamai
Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions.
Journal of pharmaceutical sciences 2013;102(1):280-8.
2013: Ikumi Tamai
Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21).
Biopharmaceutics & drug disposition 2013;34(1):29-44.
2012: Hiroshi Arakawa; Keiichi Kawai; Atsushi Mizokami; Takeo Nakanishi; Mikio Namiki; Tomohiro Nishimoto; Tomohiko Wakayama; Chihiro Yanagihara; Ikumi Tamai
Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions.
Biochemical pharmacology 2012;84(8):1070-7.
2012: Hiroshi Arakawa; Makoto Haga; Takeo Nakanishi; Yoshiyuki Shirasaka; Ikumi Tamai
Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5.
Biopharmaceutics & drug disposition 2012;33(6):332-41.
2012: Atsushi Hosomi; Takeo Nakanishi; Takuya Fujita; Ikumi Tamai
Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2.
PloS one 2012;7(2):e30456.
2012: Yoshiyuki Shirasaka; Takanori Mori; Takeo Nakanishi; Megumi Shichiri; Ikumi Tamai
Functional pleiotropy of organic anion transporting polypeptide OATP2B1 due to multiple binding sites.
Drug metabolism and pharmacokinetics 2012;27(3):360-4.
2012: Takeo Nakanishi; Ikumi Tamai
Genetic polymorphisms of OATP transporters and their impact on intestinal absorption and hepatic disposition of drugs.
Drug metabolism and pharmacokinetics 2012;27(1):106-21.
2011: Takeo Nakanishi; Kazuyo Ohe; Masanobu Sato; Yoshiyuki Shirasaka; Akimasa Fukushi; Tomoka Gose; Keiichi Kawai; Masato Kobayashi; Mayuko Yoshifuji; Ikumi Tamai
Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture.
Molecular pharmaceutics 2011;8(6):2142-50.
2011: Takeo Nakanishi; Ikumi Tamai
Solute carrier transporters as targets for drug delivery and pharmacological intervention for chemotherapy.
Journal of pharmaceutical sciences 2011;100(9):3731-50.
2011: Yoshiyuki Shirasaka; Kensuke Suzuki; Takeo Nakanishi; Ikumi Tamai
Differential effect of grapefruit juice on intestinal absorption of statins due to inhibition of organic anion transporting polypeptide and/or P-glycoprotein.
Journal of pharmaceutical sciences 2011;100(9):3843-53.
2011: Takeo Nakanishi; Yuta Shibue; Yoko Fukuyama; Kenji Yoshida; Hajime Fukuda; Yoshiyuki Shirasaka; Ikumi Tamai
Quantitative time-lapse imaging-based analysis of drug-drug interaction mediated by hepatobiliary transporter, multidrug resistance-associated protein 2, in sandwich-cultured rat hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(6):984-91.
2011: Masanobu Sato; Tomohiko Wakayama; Hideaki Mamada; Yoshiyuki Shirasaka; Takeo Nakanishi; Ikumi Tamai
Identification and functional characterization of uric acid transporter Urat1 (Slc22a12) in rats.
Biochimica et biophysica acta 2011;1808(6):1441-7.
2011: Masaya Mizutani; Fuyuhiko Inagaki; Takeo Nakanishi; Chihiro Yanagihara; Ikumi Tamai; Chisato Mukai
Total syntheses of (-)- and (+)-goniomitine.
Organic letters 2011;13(7):1796-9.
2011: Yoshiyuki Shirasaka; Kensuke Suzuki; Megumi Shichiri; Takeo Nakanishi; Ikumi Tamai
Intestinal absorption of HMG-CoA reductase inhibitor pitavastatin mediated by organic anion transporting polypeptide and P-glycoprotein/multidrug resistance 1.
Drug metabolism and pharmacokinetics 2011;26(2):171-9.
2011: Takeo Nakanishi; Tsunemitsu Haruta; Yoshiyuki Shirasaka; Ikumi Tamai
Organic cation transporter-mediated renal secretion of ipratropium and tiotropium in rats and humans.
Drug metabolism and disposition: the biological fate of chemicals 2011;39(1):117-22.
2010: Yoshiyuki Shirasaka; Kensuke Suzuki; Takeo Nakanishi; Ikumi Tamai
Intestinal absorption of HMG-CoA reductase inhibitor pravastatin mediated by organic anion transporting polypeptide.
Pharmaceutical research 2010;27(10):2141-9.
2010: Tomoji Maeda; Masanori Irokawa; Hiroshi Arakawa; Erika Kuraoka; Takashi Nozawa; Ryoko Tateoka; Yoshiharu Itoh; Takeo Nakanishi; Ikumi Tamai
Uptake transporter organic anion transporting polypeptide 1B3 contributes to the growth of estrogen-dependent breast cancer.
The Journal of steroid biochemistry and molecular biology 2010;122(4):180-5.
2010: Tomoko Sugiura; Sayaka Kato; Takuya Shimizu; Tomohiko Wakayama; Noritaka Nakamichi; Yoshiyuki Kubo; Daisuke Iwata; Kazuhiro Suzuki; Tomoyoshi Soga; Masahide Asano; Shoichi Iseki; Ikumi Tamai; Akira Tsuji; Yukio Kato
Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(10):1665-72.
2010: Hajime Fukuda; Rikiya Ohashi; Noriko Ohashi; Hikaru Yabuuchi; Ikumi Tamai
Estimation of transporters involved in the hepatobiliary transport of TA-0201CA using sandwich-cultured rat hepatocytes from normal and multidrug resistance-associated protein 2-deficient rats.
Drug metabolism and disposition: the biological fate of chemicals 2010;38(9):1505-13.
2010: Yan Li; Yoshiyuki Shirasaka; Peter Langguth; Ikumi Tamai
Quantitation of talinolol in rat plasma by LC-MS-MS.
Journal of chromatographic science 2010;48(5):367-70.
2010: Toshimichi Nakamura; Takeo Nakanishi; Tsunemitsu Haruta; Yoshiyuki Shirasaka; John P Keogh; Ikumi Tamai
Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption.
Molecular pharmaceutics 2010;7(1):187-95.
2010: Masanobu Sato; Hideaki Mamada; Naohiko Anzai; Yoshiyuki Shirasaka; Takeo Nakanishi; Ikumi Tamai
Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human.
Biological & pharmaceutical bulletin 2010;33(3):498-503.
2010: Yoshiyuki Shirasaka; Erika Kuraoka; Hildegard Spahn-Langguth; Takeo Nakanishi; Peter Langguth; Ikumi Tamai
Species difference in the effect of grapefruit juice on intestinal absorption of talinolol between human and rat.
The Journal of pharmacology and experimental therapeutics 2010;332(1):181-9.
2009: Keisuke Mitsuoka; Ikumi Tamai; Yasushi Morohashi; Yoshiyuki Kubo; Ryoichi Saitoh; Akira Tsuji; Yukio Kato
Direct evidence for efficient transport and minimal metabolism of L-cephalexin by oligopeptide transporter 1 in budded baculovirus fraction.
Biological & pharmaceutical bulletin 2009;32(8):1459-61.
2009: Akihiro Kikuchi; Takahiro Tomoyasu; Michinori Tanaka; Kayoko Kanamitsu; Hiroyuki Sasabe; Tomoji Maeda; Masaaki Odomi; Ikumi Tamai
Peptide derivation of poorly absorbable drug allows intestinal absorption via peptide transporter.
Journal of pharmaceutical sciences 2009;98(5):1775-87.
2009: Keisuke Mitsuoka; Yoshiyuki Shirasaka; Akimasa Fukushi; Masanobu Sato; Toshimichi Nakamura; Takeo Nakanishi; Ikumi Tamai
Transport characteristics of L-citrulline in renal apical membrane of proximal tubular cells.
Biopharmaceutics & drug disposition 2009;30(3):126-37.
2009: Ryo Kato; Tomoji Maeda; Toshihiro Akaike; Ikumi Tamai
Characterization of nucleobase transport by mouse Sertoli cell line TM4.
Biological & pharmaceutical bulletin 2009;32(3):450-5.
2009: Yoshiyuki Shirasaka; Yan Li; Yuta Shibue; Erika Kuraoka; Hildegard Spahn-Langguth; Yukio Kato; Peter Langguth; Ikumi Tamai
Concentration-dependent effect of naringin on intestinal absorption of beta(1)-adrenoceptor antagonist talinolol mediated by p-glycoprotein and organic anion transporting polypeptide (Oatp).
Pharmaceutical research 2009;26(3):560-7.
2008: Toshimichi Nakamura; Kenji Yoshida; Hikaru Yabuuchi; Tomoji Maeda; Ikumi Tamai
Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4).
Biological & pharmaceutical bulletin 2008;31(8):1580-4.
2008: Tomoji Maeda; Takeru Wakasawa; Miho Funabashi; Akimasa Fukushi; Masaharu Fujita; Kiyoto Motojima; Ikumi Tamai
Regulation of Octn2 transporter (SLC22A5) by peroxisome proliferator activated receptor alpha.
Biological & pharmaceutical bulletin 2008;31(6):1230-6.
2008: Yukio Kato; Seiko Takahara; Sayaka Kato; Yoshiyuki Kubo; Yoshimichi Sai; Ikumi Tamai; Hikaru Yabuuchi; Akira Tsuji
Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of beta-lactam antibiotics.
Drug metabolism and disposition: the biological fate of chemicals 2008;36(6):1088-96.
2008: Katsumasa Otake; Hiroshi Suzuki; Ryunosuke Higashi; Hikaru Yabuuchi; Makoto Haga; Tomoji Maeda; Thomas J Cook; Ikumi Tamai
Improved intestinal membrane permeability of hexose-quinoline derivatives via the hexose transporter, SGLT1.
Journal of pharmaceutical sciences 2008;97(5):1821-30.
2008: Masanori Nakakariya; Taiki Shimada; Masanori Irokawa; Hiroyuki Koibuchi; Takashi Iwanaga; Hikaru Yabuuchi; Tomoji Maeda; Ikumi Tamai
Predominant contribution of rat organic anion transporting polypeptide-2 (Oatp2) to hepatic uptake of beta-lactam antibiotics.
Pharmaceutical research 2008;25(3):578-85.
2008: Masanobu Sato; Takashi Iwanaga; Hideaki Mamada; Toshio Ogihara; Hikaru Yabuuchi; Tomoji Maeda; Ikumi Tamai
Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers.
Pharmaceutical research 2008;25(3):639-46.
2008: Naoki Ishiguro; Masanobu Oyabu; Toshihiro Sato; Tomoji Maeda; Hironobu Minami; Ikumi Tamai
Decreased biosynthesis of lung surfactant constituent phosphatidylcholine due to inhibition of choline transporter by gefitinib in lung alveolar cells.
Pharmaceutical research 2008;25(2):417-27.
2008: Masanori Nakakariya; Taiki Shimada; Masanori Irokawa; Tomoji Maeda; Ikumi Tamai
Identification and species similarity of OATP transporters responsible for hepatic uptake of beta-lactam antibiotics.
Drug metabolism and pharmacokinetics 2008;23(5):347-55.
2008: Yan Li; Masanobu Sato; Yuichi Yanagisawa; Hideaki Mamada; Akimasa Fukushi; Kentaro Mikami; Yoshiyuki Shirasaka; Ikumi Tamai
Effects of angiotensin II receptor blockers on renal handling of uric acid in rats.
Drug metabolism and pharmacokinetics 2008;23(4):263-70.
2008: Yukio Kato; Ikumi Tamai
New aspects of transporter research: future may exist "beyond the transport". Preface.
Drug metabolism and pharmacokinetics 2008;23(4):221-2.
2008: Tomoji Maeda; Yoichiro Shima; Shigeki Sugiura; Shin Aizawa; Ikumi Tamai
Changes of differentiation and proliferation in k562 cells with various levels of knockdown of cationic amino acid transporter 1.
Drug metabolism and pharmacokinetics 2008;23(3):181-7.
2008: Tomoji Maeda; Takafumi Yotsumoto; Masanobu Oyabu; Ikumi Tamai
Effect of glucocorticoid receptor ligand dexamethasone on the expression of organic cation transporter in rat liver.
Drug metabolism and pharmacokinetics 2008;23(1):67-72.
2007: Daisuke Kobayashi; Ikumi Tamai; Yoshimichi Sai; Kazuhiro Yoshida; Tomohiko Wakayama; Yasuto Kido; Jun-ichi Nezu; Shoichi Iseki; Akira Tsuji
Transport of carnitine and acetylcarnitine by carnitine/organic cation transporter (OCTN) 2 and OCTN3 into epididymal spermatozoa.
Reproduction (Cambridge, England) 2007;134(5):651-8.
2007: Shin-ichi Matsumoto; Kenji Yoshida; Naoki Ishiguro; Tomoji Maeda; Ikumi Tamai
Involvement of rat and human organic anion transporter 3 in the renal tubular secretion of topotecan [(S)-9-dimethylaminomethyl-10-hydroxy-camptothecin hydrochloride].
The Journal of pharmacology and experimental therapeutics 2007;322(3):1246-52.
2007: Tomoji Maeda; Masanobu Oyabu; Takafumi Yotsumoto; Ryunosuke Higashi; Kiyoshi Nagata; Yasushi Yamazoe; Ikumi Tamai
Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(9):1580-6.
2007: Toshimichi Nakamura; Shigeki Sugiura; Daisuke Kobayashi; Kenji Yoshida; Hikaru Yabuuchi; Shin Aizawa; Tomoji Maeda; Ikumi Tamai
Decreased proliferation and erythroid differentiation of K562 cells by siRNA-induced depression of OCTN1 (SLC22A4) transporter gene.
Pharmaceutical research 2007;24(9):1628-35.
2007: Tomoji Maeda; Akihiko Goto; Daisuke Kobayashi; Ikumi Tamai
Transport of organic cations across the blood-testis barrier.
Molecular pharmaceutics 2007;4(4):600-7.
2007: Takashi Iwanaga; Masanori Nakakariya; Hikaru Yabuuchi; Tomoji Maeda; Ikumi Tamai
Involvement of bile salt export pump in flutamide-induced cholestatic hepatitis.
Biological & pharmaceutical bulletin 2007;30(4):739-44.
2007: Tomoji Maeda; Masamichi Hirayama; Daisuke Kobayashi; Keiji Miyazawa; Ikumi Tamai
Mechanism of the regulation of organic cation/carnitine transporter 1 (SLC22A4) by rheumatoid arthritis-associated transcriptional factor RUNX1 and inflammatory cytokines.
Drug metabolism and disposition: the biological fate of chemicals 2007;35(3):394-401.
2007: Tomoji Maeda; Koichi Takahashi; Naoko Ohtsu; Toshihiro Oguma; Toshimasa Ohnishi; Ryo Atsumi; Ikumi Tamai
Identification of influx transporter for the quinolone antibacterial agent levofloxacin.
Molecular pharmaceutics 2007;4(1):85-94.
2007: Takashi Iwanaga; Masanobu Sato; Tomoji Maeda; Toshio Ogihara; Ikumi Tamai
Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter.
The Journal of pharmacology and experimental therapeutics 2007;320(1):211-7.
2006: Yukio Kato; Mikihiro Sugiura; Tomoko Sugiura; Tomohiko Wakayama; Yoshiyuki Kubo; Daisuke Kobayashi; Yoshimichi Sai; Ikumi Tamai; Shoichi Iseki; Akira Tsuji
Organic cation/carnitine transporter OCTN2 (Slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse.
Molecular pharmacology 2006;70(3):829-37.
2006: Akihiro Kikuchi; Takashi Nozawa; Takeru Wakasawa; Tomoji Maeda; Ikumi Tamai
Transporter-mediated intestinal absorption of fexofenadine in rats.
Drug metabolism and pharmacokinetics 2006;21(4):308-14.
2006: Yoshimichi Sai; Yosuke Kaneko; Satsuki Ito; Keisuke Mitsuoka; Yukio Kato; Ikumi Tamai; Per Artursson; Akira Tsuji
Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells.
Drug metabolism and disposition: the biological fate of chemicals 2006;34(8):1423-31.
2006: Tomoji Maeda; Masamichi Hirayama; Ryunosuke Higashi; Masanobu Sato; Ikumi Tamai
Characterization of human OATP2B1 (SLCO2B1) gene promoter regulation.
Pharmaceutical research 2006;23(3):513-20.
2006: Yoichiro Shima; Tomoji Maeda; Shin Aizawa; Isao Tsuboi; Daisuke Kobayashi; Ryo Kato; Ikumi Tamai
L-arginine import via cationic amino acid transporter CAT1 is essential for both differentiation and proliferation of erythrocytes.
Blood 2006;107(4):1352-6.
2006: Tomoji Maeda; Takeru Wakasawa; Yoichiro Shima; Isao Tsuboi; Shin Aizawa; Ikumi Tamai
Role of polyamines derived from arginine in differentiation and proliferation of human blood cells.
Biological & pharmaceutical bulletin 2006;29(2):234-9.
2006: Yoshimichi Sai; Yukio Kato; Keiko Nakamura; Sayaka Kato; Tomohiro Nishimura; Yoshiyuki Kubo; Ikumi Tamai; Shu Yang; Zhuhan Hu; Ichimaro Yamada; Akira Tsuji
Carrier-mediated hepatic uptake of a novel nonrenal excretion type uric acid generation inhibitor, Y-700.
Journal of pharmaceutical sciences 2006;95(2):336-47.
2005: Daisuke Kobayashi; Masanori Irokawa; Tomoji Maeda; Akira Tsuji; Ikumi Tamai
Carnitine/organic cation transporter OCTN2-mediated transport of carnitine in primary-cultured epididymal epithelial cells.
Reproduction (Cambridge, England) 2005;130(6):931-7.
2005: Takashi Iwanaga; Daisuke Kobayashi; Masamichi Hirayama; Tomoji Maeda; Ikumi Tamai
Involvement of uric acid transporter in increased renal clearance of the xanthine oxidase inhibitor oxypurinol induced by a uricosuric agent, benzbromarone.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(12):1791-5.
2005: Takashi Nozawa; Masato Suzuki; Hikaru Yabuuchi; Masanori Irokawa; Akira Tsuji; Ikumi Tamai
Suppression of cell proliferation by inhibition of estrone-3-sulfate transporter in estrogen-dependent breast cancer cells.
Pharmaceutical research 2005;22(10):1634-41.
2005: Tomoji Maeda; Masamichi Hirayama; Daisuke Kobayashi; Ikumi Tamai
Regulation of testis-specific carnitine transporter (octn3) gene by proximal cis-acting elements Sp1 in mice.
Biochemical pharmacology 2005;70(6):858-68.
2005: Daisuke Kobayashi; Akihiko Goto; Tomoji Maeda; Jun-Ichi Nezu; Akira Tsuji; Ikumi Tamai
OCTN2-mediated transport of carnitine in isolated Sertoli cells.
Reproduction (Cambridge, England) 2005;129(6):729-36.
2005: Naoki Ishiguro; Asami Saito; Kazutoshi Yokoyama; Makoto Morikawa; Takashi Igarashi; Ikumi Tamai
Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(4):495-9.
2005: Takashi Nozawa; Hironobu Minami; Shigeki Sugiura; Akira Tsuji; Ikumi Tamai
Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.
Drug metabolism and disposition: the biological fate of chemicals 2005;33(3):434-9.
2005: Ryo Kato; Tomoji Maeda; Toshihiro Akaike; Ikumi Tamai
Nucleoside transport at the blood-testis barrier studied with primary-cultured sertoli cells.
The Journal of pharmacology and experimental therapeutics 2005;312(2):601-8.
2004: Daisuke Kobayashi; Shin Aizawa; Tomoji Maeda; Isao Tsuboi; Hikaru Yabuuchi; Jun-ichi Nezu; Akira Tsuji; Ikumi Tamai
Expression of organic cation transporter OCTN1 in hematopoietic cells during erythroid differentiation.
Experimental hematology 2004;32(12):1156-62.
2004: Takashi Nozawa; Masato Suzuki; Koichi Takahashi; Hikaru Yabuuchi; Tomoji Maeda; Akira Tsuji; Ikumi Tamai
Involvement of estrone-3-sulfate transporters in proliferation of hormone-dependent breast cancer cells.
The Journal of pharmacology and experimental therapeutics 2004;311(3):1032-7.
2004: Tomoji Maeda; Masaaki Miyata; Takafumi Yotsumoto; Daisuke Kobayashi; Takashi Nozawa; Keisuke Toyama; Frank J Gonzalez; Yasushi Yamazoe; Ikumi Tamai
Regulation of drug transporters by the farnesoid X receptor in mice.
Molecular pharmaceutics 2004;1(4):281-9.
2004: Akihiro Inano; Yoshimichi Sai; Yukio Kato; Ikumi Tamai; Masaji Ishiguro; Akira Tsuji
Functional regions of organic cation/carnitine transporter OCTN2 (SLC22A5): roles in carnitine recognition.
Drug metabolism and pharmacokinetics 2004;19(3):180-9.
2004: Naoki Ishiguro; Takashi Nozawa; Akiko Tsujihata; Asami Saito; Wataru Kishimoto; Kazutoshi Yokoyama; Takafumi Yotsumoto; Kenji Sakai; Takashi Igarashi; Ikumi Tamai
Influx and efflux transport of H1-antagonist epinastine across the blood-brain barrier.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(5):519-24.
2004: Takashi Nozawa; Shigeki Sugiura; Miki Nakajima; Akihiko Goto; Tsuyoshi Yokoi; Jun-Ichi Nezu; Akira Tsuji; Ikumi Tamai
Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity.
Drug metabolism and disposition: the biological fate of chemicals 2004;32(3):291-4.
2004: Takashi Nozawa; Shigeki Sugiura; Yumi Hashino; Akira Tsuji; Ikumi Tamai
Role of anion exchange transporter PAT1 (SLC26A6) in intestinal absorption of organic anions.
Journal of drug targeting 2004;12(2):97-104.
2004: Qing Li; Yoshimichi Sai; Yukio Kato; Hiromi Muraoka; Ikumi Tamai; Akira Tsuji
Transporter-mediated renal handling of nafamostat mesilate.
Journal of pharmaceutical sciences 2004;93(2):262-72.
2004: Takashi Nozawa; Kozue Imai; Jun-ichi Nezu; Akira Tsuji; Ikumi Tamai
Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human.
The Journal of pharmacology and experimental therapeutics 2004;308(2):438-45.
2004: Ikumi Tamai; Takeo Nakanishi; Daisuke Kobayashi; Kayoko China; Yohei Kosugi; Jun-ichi Nezu; Yoshimichi Sai; Akira Tsuji
Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations.
Molecular pharmaceutics 2004;1(1):57-66.
2003: Hidekazu Toyobuku; Ikumi Tamai; Kazuyuki Ueno; Akira Tsuji
Limited influence of P-glycoprotein on small-intestinal absorption of cilostazol, a high absorptive permeability drug.
Journal of pharmaceutical sciences 2003;92(11):2249-59.
2003: Takashi Nozawa; Hidekazu Toyobuku; Daisuke Kobayashi; Keiko Kuruma; Akira Tsuji; Ikumi Tamai
Enhanced intestinal absorption of drugs by activation of peptide transporter PEPT1 using proton-releasing polymer.
Journal of pharmaceutical sciences 2003;92(11):2208-16.
2003: Akihiro Inano; Yoshimichi Sai; Hiroko Nikaido; Noriyoshi Hasimoto; Masahide Asano; Akira Tsuji; Ikumi Tamai
Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2.
Biopharmaceutics & drug disposition 2003;24(8):357-65.
2003: Qing Li; Yoshimichi Sai; Yukio Kato; Ikumi Tamai; Akira Tsuji
Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cell lines.
Pharmaceutical research 2003;20(8):1119-24.
2003: Daisuke Kobayashi; Takashi Nozawa; Kozue Imai; Jun-ichi Nezu; Akira Tsuji; Ikumi Tamai
Involvement of human organic anion transporting polypeptide OATP-B (SLC21A9) in pH-dependent transport across intestinal apical membrane.
The Journal of pharmacology and experimental therapeutics 2003;306(2):703-8.
2003: Takashi Nozawa; Ikumi Tamai; Yoshimichi Sai; Jun-ichi Nezu; Akira Tsuji
Contribution of organic anion transporting polypeptide OATP-C to hepatic elimination of the opioid pentapeptide analogue [D-Ala2, D-Leu5]-enkephalin.
The Journal of pharmacy and pharmacology 2003;55(7):1013-20.
2003: Kazumasa Naruhashi; Ikumi Tamai; Qing Li; Yoshimichi Sai; Akira Tsuji
Experimental demonstration of the unstirred water layer effect on drug transport in Caco-2 cells.
Journal of pharmaceutical sciences 2003;92(7):1502-8.
2003: Hidekazu Toyobuku; Yoshimichi Sai; Toru Kagami; Ikumi Tamai; Akira Tsuji
Delivery of peptide drugs to the brain by adenovirus-mediated heterologous expression of human oligopeptide transporter at the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 2003;305(1):40-7.
2002: Kazumasa Naruhashi; Yoshimichi Sai; Ikumi Tamai; Nagao Suzuki; Akira Tsuji
PepT1 mRNA expression is induced by starvation and its level correlates with absorptive transport of cefadroxil longitudinally in the rat intestine.
Pharmaceutical research 2002;19(10):1417-23.
2002: Rikiya Ohashi; Ikumi Tamai; Akihiro Inano; Masaki Katsura; Yoshimichi Sai; Jun-ichi Nezu; Akira Tsuji
Studies on functional sites of organic cation/carnitine transporter OCTN2 (SLC22A5) using a Ser467Cys mutant protein.
The Journal of pharmacology and experimental therapeutics 2002;302(3):1286-94.
2002: Takashi Nozawa; Miki Nakajima; Ikumi Tamai; Kumiko Noda; Jun-ichi Nezu; Yoshimichi Sai; Akira Tsuji; Tsuyoshi Yokoi
Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis.
The Journal of pharmacology and experimental therapeutics 2002;302(2):804-13.
2002: Hidekazu Toyobuku; Yoshimichi Sai; Ikumi Tamai; Akira Tsuji
Enhanced delivery of drugs to the liver by adenovirus-mediated heterologous expression of the human oligopeptide transporter PEPT1.
The Journal of pharmacology and experimental therapeutics 2002;301(3):812-9.
2002: Kazumasa Naruhashi; Ikumi Tamai; Natsuko Inoue; Hiromi Muraoka; Yoshimichi Sai; Nagao Suzuki; Akira Tsuji
Involvement of multidrug resistance-associated protein 2 in intestinal secretion of grepafloxacin in rats.
Antimicrobial agents and chemotherapy 2002;46(2):344-9.
2002: Yasuto Kido; Ikumi Tamai; Takeo Nakanishi; Toru Kagami; Iori Hirosawa; Yoshimichi Sai; Akira Tsuji
Evaluation of blood-brain barrier transporters by co-culture of brain capillary endothelial cells with astrocytes.
Drug metabolism and pharmacokinetics 2002;17(1):34-41.
2001: Yasuto Kido; Ikumi Tamai; A Ohnari; Yoshimichi Sai; Toru Kagami; Jun-ichi Nezu; Hiroko Nikaido; Nobuo Hashimoto; Masahide Asano; Akira Tsuji
Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier.
Journal of neurochemistry 2001;79(5):959-69.
2001: Ikumi Tamai; Takashi Nozawa; M Koshida; Jun-ichi Nezu; Yoshimichi Sai; Akira Tsuji
Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.
Pharmaceutical research 2001;18(9):1262-9.
2001: Ikumi Tamai; Kayoko China; Yoshimichi Sai; Daisuke Kobayashi; Jun-ichi Nezu; Ei Kawahara; Akira Tsuji
Na(+)-coupled transport of L-carnitine via high-affinity carnitine transporter OCTN2 and its subcellular localization in kidney.
Biochimica et biophysica acta 2001;1512(2):273-84.
2001: Kazumasa Naruhashi; Ikumi Tamai; N Inoue; Hiromi Muraoka; Yoshimichi Sai; Nagao Suzuki; Akira Tsuji
Active intestinal secretion of new quinolone antimicrobials and the partial contribution of P-glycoprotein.
The Journal of pharmacy and pharmacology 2001;53(5):699-709.
2001: Y Higashi; Koichi Yokogawa; N Takeuchi; Ikumi Tamai; Masaaki Nomura; Nobuo Hashimoto; JI Hayakawa; Ken-ichi Miyamoto; Akira Tsuji
Effect of gamma-butyrobetaine on fatty liver in juvenile visceral steatosis mice.
The Journal of pharmacy and pharmacology 2001;53(4):527-33.
2001: Y Kido; Ikumi Tamai; H Uchino; F Suzuki; Yoshimichi Sai; Akira Tsuji
Molecular and functional identification of large neutral amino acid transporters LAT1 and LAT2 and their pharmacological relevance at the blood-brain barrier.
The Journal of pharmacy and pharmacology 2001;53(4):497-503.
2001: Rikiya Ohashi; Ikumi Tamai; J Nezu Ji; Hiroko Nikaido; Nobuo Hashimoto; A Oku; Yoshimichi Sai; Miyuki Shimane; Akira Tsuji
Molecular and physiological evidence for multifunctionality of carnitine/organic cation transporter OCTN2.
Molecular pharmacology 2001;59(2):358-66.
2001: Kazumasa Naruhashi; Ikumi Tamai; Yoshimichi Sai; Nagao Suzuki; Akira Tsuji
Secretory transport of p-aminohippuric acid across intestinal epithelial cells in Caco-2 cells and isolated intestinal tissue.
The Journal of pharmacy and pharmacology 2001;53(1):73-81.
2000: Ikumi Tamai; Rikiya Ohashi; Jun-ichi Nezu; Yoshimichi Sai; Daisuke Kobayashi; A Oku; Miyuki Shimane; Akira Tsuji
Molecular and functional characterization of organic cation/carnitine transporter family in mice.
The Journal of biological chemistry 2000;275(51):40064-72.
2000: Ikumi Tamai; Akira Tsuji
Transporter-mediated permeation of drugs across the blood-brain barrier.
Journal of pharmaceutical sciences 2000;89(11):1371-88.
2000: Takeo Nakanishi; Ikumi Tamai; A Takaki; Akira Tsuji
Cancer cell-targeted drug delivery utilizing oligopeptide transport activity.
International journal of cancer. Journal international du cancer 2000;88(2):274-80.
2000: Ikumi Tamai; Junkoh Yamashita; Y Kido; A Ohnari; Yoshimichi Sai; Y Shima; Kazumasa Naruhashi; Shoichi Koizumi; Akira Tsuji
Limited distribution of new quinolone antibacterial agents into brain caused by multiple efflux transporters at the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 2000;295(1):146-52.
2000: Ikumi Tamai; T Ogihara; H Takanaga; H Maeda; Akira Tsuji
Anion antiport mechanism is involved in transport of lactic acid across intestinal epithelial brush-border membrane.
Biochimica et biophysica acta 2000;1468(1-2):285-92.
2000: T Ogihara; Ikumi Tamai; A Tsuji
In situ and in vitro evidence for stereoselective and carrier-mediated transport of monocarboxylic acids across intestinal epithelial tissue.
Biological & pharmaceutical bulletin 2000;23(7):855-9.
2000: Ikumi Tamai; Jun-ichi Nezu; H Uchino; Yoshimichi Sai; A Oku; Miyuki Shimane; Akira Tsuji
Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.
Biochemical and biophysical research communications 2000;273(1):251-60.
2000: H Uchino; Ikumi Tamai; Katsumi Yamashita; Yuzuru Minemoto; Yoshimichi Sai; H Yabuuchi; K i Miyamoto; E Takeda; Akira Tsuji
p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1.
Biochemical and biophysical research communications 2000;270(1):254-9.
2000: H Uchino; Ikumi Tamai; H Yabuuchi; Kayoko China; Ken-ichi Miyamoto; E Takeda; Akira Tsuji
Faropenem transport across the renal epithelial luminal membrane via inorganic phosphate transporter Npt1.
Antimicrobial agents and chemotherapy 2000;44(3):574-7.
2000: Y Kido; Ikumi Tamai; M Okamoto; F Suzuki; Akira Tsuji
Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies.
Pharmaceutical research 2000;17(1):55-62.
2000: Ertan Mayatepek; Jun-ichi Nezu; Ikumi Tamai; A Oku; M Katsura; Miyuki Shimane; Akira Tsuji
Two novel missense mutations of the OCTN2 gene (W283R and V446F) in a patient with primary systemic carnitine deficiency.
Human mutation 2000;15(1):118.
1999: M Kawahara; A Sakata; T Miyashita; Ikumi Tamai; Akira Tsuji
Physiologically based pharmacokinetics of digoxin in mdr1a knockout mice.
Journal of pharmaceutical sciences 1999;88(12):1281-7.
1999: Takuo Ogihara; Ikumi Tamai; Akira Tsuji
Structural characterization of substrates for the anion exchange transporter in Caco-2 cells.
Journal of pharmaceutical sciences 1999;88(11):1217-21.
1999: Rikiya Ohashi; Ikumi Tamai; Hikaru Yabuuchi; Jun-ichi Nezu; A Oku; Yoshimichi Sai; Miyuki Shimane; Akira Tsuji
Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance.
The Journal of pharmacology and experimental therapeutics 1999;291(2):778-84.
1999: Ikumi Tamai; Yoshimichi Sai; A Ono; Y Kido; Hikaru Yabuuchi; Hitomi Takanaga; E Satoh; Takuo Ogihara; Osamu Amano; S Izeki; Akira Tsuji
Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1.
The Journal of pharmacy and pharmacology 1999;51(10):1113-21.
1999: Koichi Yokogawa; M Yonekawa; Ikumi Tamai; Rikiya Ohashi; Y Tatsumi; Y Higashi; Masaaki Nomura; Nobuo Hashimoto; Hiroko Nikaido; JI Hayakawa; Jun-ichi Nezu; A Oku; Miyuki Shimane; Ken-ichi Miyamoto; Akira Tsuji
Loss of wild-type carrier-mediated L-carnitine transport activity in hepatocytes of juvenile visceral steatosis mice.
Hepatology (Baltimore, Md.) 1999;30(4):997-1001.
1999: Koichi Yokogawa; K Miya; Ikumi Tamai; Y Higashi; Masaaki Nomura; Ken-ichi Miyamoto; Akira Tsuji
Characteristics of L-carnitine transport in cultured human hepatoma HLF cells.
The Journal of pharmacy and pharmacology 1999;51(8):935-40.
1999: Koichi Yokogawa; M Takahashi; Ikumi Tamai; H Konishi; Masaaki Nomura; Shuzo Moritani; Ken-ichi Miyamoto; Akira Tsuji
P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice.
Pharmaceutical research 1999;16(8):1213-8.
1999: M Murata; Ikumi Tamai; H Kato; O Nagata; Akira Tsuji
Efflux transport of a new quinolone antibacterial agent, HSR-903, across the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 1999;290(1):51-7.
1999: Hikaru Yabuuchi; Ikumi Tamai; Jun-ichi Nezu; K Sakamoto; A Oku; Miyuki Shimane; Yoshimichi Sai; Akira Tsuji
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
The Journal of pharmacology and experimental therapeutics 1999;289(2):768-73.
1999: Koichi Yokogawa; Y Higashi; Ikumi Tamai; Masaaki Nomura; Nobuo Hashimoto; Hiroko Nikaido; JI Hayakawa; Ken-ichi Miyamoto; Akira Tsuji
Decreased tissue distribution of L-carnitine in juvenile visceral steatosis mice.
The Journal of pharmacology and experimental therapeutics 1999;289(1):224-30.
1999: M Murata; Ikumi Tamai; Yoshimichi Sai; O Nagata; H Kato; Akira Tsuji
Carrier-mediated lung distribution of HSR-903, a new quinolone antibacterial agent.
The Journal of pharmacology and experimental therapeutics 1999;289(1):79-84.
1999: Akira Tsuji; Ikumi Tamai
Organic anion transporters.
Pharmaceutical biotechnology 1999;12():471-91.
1999: Jun-ichi Nezu; Ikumi Tamai; A Oku; Rikiya Ohashi; Hikaru Yabuuchi; Nobuo Hashimoto; Hiroko Nikaido; Yoshimichi Sai; A Koizumi; Y Shoji; G Takada; T Matsuishi; M Yoshino; H Kato; T Ohura; G Tsujimoto; JI Hayakawa; Miyuki Shimane; Akira Tsuji
Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter.
Nature genetics 1999;21(1):91-4.
1998: Ikumi Tamai; Takeo Nakanishi; H Nakahara; Yoshimichi Sai; Vadivel Ganapathy; F H Leibach; Akira Tsuji
Improvement of L-dopa absorption by dipeptidyl derivation, utilizing peptide transporter PepT1.
Journal of pharmaceutical sciences 1998;87(12):1542-6.
1998: Hikaru Yabuuchi; Ikumi Tamai; K Morita; T Kouda; Ken-ichi Miyamoto; E Takeda; Akira Tsuji
Hepatic sinusoidal membrane transport of anionic drugs mediated by anion transporter Npt1.
The Journal of pharmacology and experimental therapeutics 1998;286(3):1391-6.
1998: Yoshimichi Sai; M Kajita; Ikumi Tamai; J Wakama; T Wakamiya; Akira Tsuji
Adsorptive-mediated endocytosis of a basic peptide in enterocyte-like Caco-2 cells.
The American journal of physiology 1998;275(3 Pt 1):G514-20.
1998: Ikumi Tamai; Rikiya Ohashi; Jun-ichi Nezu; Hikaru Yabuuchi; A Oku; Miyuki Shimane; Yoshimichi Sai; Akira Tsuji
Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2.
The Journal of biological chemistry 1998;273(32):20378-82.
1998: Yoshimichi Sai; M Kajita; Ikumi Tamai; J Wakama; T Wakamiya; Akira Tsuji
Adsorptive-mediated transcytosis of a synthetic basic peptide, 001-C8 in Caco-2 cells.
Pharmaceutical research 1998;15(8):1305-9.
1998: Yoshimichi Sai; M Kajita; Ikumi Tamai; M Kamata; J Wakama; T Wakamiya; Akira Tsuji
Intestinal absorption of fluorescence-derivatized cationic peptide 001-C8-NBD via adsorptive-mediated transcytosis.
Bioorganic & medicinal chemistry 1998;6(6):841-8.
1998: Nobuo Hashimoto; F Suzuki; Ikumi Tamai; Hiroko Nikaido; M Kuwajima; JI Hayakawa; Akira Tsuji
Gene-dose effect on carnitine transport activity in embryonic fibroblasts of JVS mice as a model of human carnitine transporter deficiency.
Biochemical pharmacology 1998;55(10):1729-32.
1998: Takuo Ogihara; Ikumi Tamai; Akira Tsuji
Application of fractal kinetics for carrier-mediated transport of drugs across intestinal epithelial membrane.
Pharmaceutical research 1998;15(4):620-5.
1998: Hikaru Yabuuchi; Ikumi Tamai; Yoshimichi Sai; Akira Tsuji
Possible role of anion exchanger AE2 as the intestinal monocarboxylic acid/anion antiporter.
Pharmaceutical research 1998;15(3):411-6.
1997: Ikumi Tamai; Hikaru Yabuuchi; Jun-ichi Nezu; Yoshimichi Sai; A Oku; Miyuki Shimane; Akira Tsuji
Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1.
FEBS letters 1997;419(1):107-11.
1997: Ikumi Tamai; A Saheki; R Saitoh; Yoshimichi Sai; Ichimaro Yamada; Akira Tsuji
Nonlinear intestinal absorption of 5-hydroxytryptamine receptor antagonist caused by absorptive and secretory transporters.
The Journal of pharmacology and experimental therapeutics 1997;283(1):108-15.
1997: Ikumi Tamai; Takeo Nakanishi; K Hayashi; T Terao; Yoshimichi Sai; T Shiraga; Ken-ichi Miyamoto; E Takeda; H Higashida; Akira Tsuji
The predominant contribution of oligopeptide transporter PepT1 to intestinal absorption of beta-lactam antibiotics in the rat small intestine.
The Journal of pharmacy and pharmacology 1997;49(8):796-801.
1997: Ikumi Tamai
[Molecular characterization of intestinal absorption of drugs by carrier-mediated transport mechanisms].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 1997;117(7):415-34.
1997: Akira Tsuji; A Sakata; Ikumi Tamai
[Tissue distribution of the multidrug-resistance gene product P-glycoprotein and its physiological function].
Nihon rinsho. Japanese journal of clinical medicine 1997;55(5):1059-63.
1997: J Komura; Ikumi Tamai; M Senmaru; T Terasaki; Yoshimichi Sai; Akira Tsuji
Brain-to-blood active transport of beta-alanine across the blood-brain barrier.
FEBS letters 1997;400(1):131-5.
1997: Ikumi Tamai; Hitomi Takanaga; H Maeda; Hikaru Yabuuchi; Yoshimichi Sai; Y Suzuki; Akira Tsuji
Intestinal brush-border membrane transport of monocarboxylic acids mediated by proton-coupled transport and anion antiport mechanisms.
The Journal of pharmacy and pharmacology 1997;49(1):108-12.
1997: Ikumi Tamai; Yoshimichi Sai; H Kobayashi; M Kamata; T Wakamiya; Akira Tsuji
Structure-internalization relationship for adsorptive-mediated endocytosis of basic peptides at the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 1997;280(1):410-5.
1996: Takuo Ogihara; Ikumi Tamai; Hitomi Takanaga; Yoshimichi Sai; A Tsuji
Stereoselective and carrier-mediated transport of monocarboxylic acids across Caco-2 cells.
Pharmaceutical research 1996;13(12):1828-32.
1996: T Terao; E Hisanaga; Yoshimichi Sai; Ikumi Tamai; A Tsuji
Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier.
The Journal of pharmacy and pharmacology 1996;48(10):1083-9.
1996: Hitomi Takanaga; H Maeda; Hikaru Yabuuchi; Ikumi Tamai; Haruhiro Higashida; A Tsuji
Nicotinic acid transport mediated by pH-dependent anion antiporter and proton cotransporter in rabbit intestinal brush-border membrane.
The Journal of pharmacy and pharmacology 1996;48(10):1073-7.
1996: Yoshimichi Sai; Ikumi Tamai; H Sumikawa; K Hayashi; Takeo Nakanishi; Osamu Amano; M Numata; Shoichi Iseki; A Tsuji
Immunolocalization and pharmacological relevance of oligopeptide transporter PepT1 in intestinal absorption of beta-lactam antibiotics.
FEBS letters 1996;392(1):25-9.
1996: A Tsuji; Ikumi Tamai
Carrier-mediated intestinal transport of drugs.
Pharmaceutical research 1996;13(7):963-77.
1996: J Komura; Ikumi Tamai; M Senmaru; Tetsuya Terasaki; Yoshimichi Sai; A Tsuji
Sodium and chloride ion-dependent transport of beta-alanine across the blood-brain barrier.
Journal of neurochemistry 1996;67(1):330-5.
1996: T Yamada; O Nagata; Ikumi Tamai; A Tsuji
Effect of polycarbophil on the absorption of nutrients.
Biological & pharmaceutical bulletin 1996;19(5):771-3.
1996: K i Miyamoto; T Shiraga; Kyoko Morita; H Yamamoto; H Haga; Yutaka Taketani; Ikumi Tamai; Y Sai; A Tsuji; Eiji Takeda
Sequence, tissue distribution and developmental changes in rat intestinal oligopeptide transporter.
Biochimica et biophysica acta 1996;1305(1-2):34-8.
1996: A Tsuji; Ikumi Tamai
Sodium- and chloride-dependent transport of taurine at the blood-brain barrier.
Advances in experimental medicine and biology 1996;403():385-91.
1995: Hitomi Takanaga; Ikumi Tamai; S Inaba; Yoshimichi Sai; Haruhiro Higashida; H Yamamoto; A Tsuji
cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter.
Biochemical and biophysical research communications 1995;217(1):370-7.
1995: Ikumi Tamai; M Senmaru; Tetsuya Terasaki; A Tsuji
Na(+)- and Cl(-)-dependent transport of taurine at the blood-brain barrier.
Biochemical pharmacology 1995;50(11):1783-93.
1995: Ikumi Tamai; Hitomi Takanaga; H Maeda; Takuo Ogihara; M Yoneda; A Tsuji
Proton-cotransport of pravastatin across intestinal brush-border membrane.
Pharmaceutical research 1995;12(11):1727-32.
1995: Ikumi Tamai; Hitomi Takanaga; H Maeda; Yoshimichi Sai; Takuo Ogihara; Haruhiro Higashida; A Tsuji
Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids.
Biochemical and biophysical research communications 1995;214(2):482-9.
1995: T Ohnishi; Ikumi Tamai; K Sakanaka; A Sakata; T Yamashima; J Yamashita; A Tsuji
In vivo and in vitro evidence for ATP-dependency of P-glycoprotein-mediated efflux of doxorubicin at the blood-brain barrier.
Biochemical pharmacology 1995;49(10):1541-4.
1995: Ikumi Tamai; N Tomizawa; T Takeuchi; K Nakayama; H Higashida; A Tsuji
Functional expression of transporter for beta-lactam antibiotics and dipeptides in Xenopus laevis oocytes injected with messenger RNA from human, rat and rabbit small intestines.
The Journal of pharmacology and experimental therapeutics 1995;273(1):26-31.
1995: Tetsuya Terasaki; H Mizuguchi; C Itoho; Ikumi Tamai; M Lemaire; A Tsuji
Hepatic uptake of octreotide, a long-acting somatostatin analogue, via a bile acid transport system.
Pharmaceutical research 1995;12(1):12-7.
1994: A Sakata; Ikumi Tamai; K Kawazu; Y Deguchi; T Ohnishi; A Saheki; A Tsuji
In vivo evidence for ATP-dependent and P-glycoprotein-mediated transport of cyclosporin A at the blood-brain barrier.
Biochemical pharmacology 1994;48(10):1989-92.
1994: Ikumi Tamai; N Tomizawa; A Kadowaki; Tetsuya Terasaki; K Nakayama; H Higashida; A Tsuji
Functional expression of intestinal dipeptide/beta-lactam antibiotic transporter in Xenopus laevis oocytes.
Biochemical pharmacology 1994;48(5):881-8.
1994: Hitomi Takanaga; Ikumi Tamai; A Tsuji
pH-dependent and carrier-mediated transport of salicylic acid across Caco-2 cells.
The Journal of pharmacy and pharmacology 1994;46(7):567-70.
1994: A Saheki; Tetsuya Terasaki; Ikumi Tamai; A Tsuji
In vivo and in vitro blood-brain barrier transport of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors.
Pharmaceutical research 1994;11(2):305-11.
1994: A Tsuji; Hitomi Takanaga; Ikumi Tamai; Tetsuya Terasaki
Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism.
Pharmaceutical research 1994;11(1):30-7.
1993: A Tsuji; A Saheki; Ikumi Tamai; Tetsuya Terasaki
Transport mechanism of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors at the blood-brain barrier.
The Journal of pharmacology and experimental therapeutics 1993;267(3):1085-90.
1993: A Tsuji; Ikumi Tamai; M Nakanishi; Tetsuya Terasaki; S Hamano
Intestinal brush-border transport of the oral cephalosporin antibiotic, cefdinir, mediated by dipeptide and monocarboxylic acid transport systems in rabbits.
The Journal of pharmacy and pharmacology 1993;45(11):996-8.
1993: A Tsuji; Ikumi Tamai; A Sakata; Y Tenda; Tetsuya Terasaki
Restricted transport of cyclosporin A across the blood-brain barrier by a multidrug transporter, P-glycoprotein.
Biochemical pharmacology 1993;46(6):1096-9.
1993: Tetsuya Terasaki; A Kadowaki; Haruhiro Higashida; K Nakayama; Ikumi Tamai; A Tsuji
Expression of the Na+ dependent uridine transport system of rabbit small intestine: studies with mRNA-injected Xenopus laevis oocytes.
Biological & pharmaceutical bulletin 1993;16(5):493-6.
1992: A Tsuji; Tetsuya Terasaki; Y Takabatake; Y Tenda; Ikumi Tamai; T Yamashima; Shuzo Moritani; T Tsuruo; J Yamashita
P-glycoprotein as the drug efflux pump in primary cultured bovine brain capillary endothelial cells.
Life sciences 1992;51(18):1427-37.
1991: M T Simanjuntak; Tetsuya Terasaki; Ikumi Tamai; A Tsuji
Participation of monocarboxylic anion and bicarbonate exchange system for the transport of acetic acid and monocarboxylic acid drugs in the small intestinal brush-border membrane vesicles.
Journal of pharmacobio-dynamics 1991;14(9):501-8.
1991: M T Simanjuntak; H Sato; Ikumi Tamai; Tetsuya Terasaki; A Tsuji
Transport of the new quinolone antibacterial agents of lomefloxacin and ofloxacin by rat erythrocytes, and its relation to the nicotinic acid transport system.
Journal of pharmacobio-dynamics 1991;14(8):475-81.
1990: A Tsuji; M T Simanjuntak; Ikumi Tamai; Tetsuya Terasaki
pH-dependent intestinal transport of monocarboxylic acids: carrier-mediated and H(+)-cotransport mechanism versus pH-partition hypothesis.
Journal of pharmaceutical sciences 1990;79(12):1123-4.
1990: Ikumi Tamai; T Maekawa; A Tsuji
Membrane potential-dependent and carrier-mediated transport of cefpiramide, a cephalosporin antibiotic, in canalicular rat liver plasma membrane vesicles.
The Journal of pharmacology and experimental therapeutics 1990;253(2):537-44.
1990: M T Simanjuntak; Ikumi Tamai; Tetsuya Terasaki; A Tsuji
Carrier-mediated uptake of nicotinic acid by rat intestinal brush-border membrane vesicles and relation to monocarboxylic acid transport.
Journal of pharmacobio-dynamics 1990;13(5):301-9.
1990: T Ishizawa; A Tsuji; Ikumi Tamai; Tetsuya Terasaki; K Hosoi; S Fukatsu
Sodium and pH dependent carrier-mediated transport of antibiotic, fosfomycin, in the rat intestinal brush-border membrane.
Journal of pharmacobio-dynamics 1990;13(5):292-300.
1990: A Tsuji; Tetsuya Terasaki; Ikumi Tamai; K Takeda
In vivo evidence for carrier-mediated uptake of beta-lactam antibiotics through organic anion transport systems in rat kidney and liver.
The Journal of pharmacology and experimental therapeutics 1990;253(1):315-20.
1990: A Tsuji; Ikumi Tamai; M Nakanishi; Gordon L Amidon
Mechanism of absorption of the dipeptide alpha-methyldopa-phe in intestinal brush-border membrane vesicles.
Pharmaceutical research 1990;7(3):308-9.
1990: A Tsuji; H Sato; Ikumi Tamai; H Adachi; T Nishihara; M Ishiguro; N Ohnuma; T Noguchi
Physiologically based pharmacokinetics of a new penem, SUN5555, for evaluation of in vivo efficacy.
Drug metabolism and disposition: the biological fate of chemicals 1990;18(2):245-52.
1989: A Tsuji; Tetsuya Terasaki; N Imaeda; K Nishide; Ikumi Tamai
Age-related change in tissue-to-plasma partition coefficient of cefazolin for noneliminating organs in the rat.
Journal of pharmaceutical sciences 1989;78(7):535-40.
1989: A Tsuji; Ikumi Tamai
Na+ and pH dependent transport of foscarnet via the phosphate carrier system across intestinal brush-border membrane.
Biochemical pharmacology 1989;38(6):1019-22.
1989: O Nagata; Tetsuya Terasaki; E Yada; H Sato; Ikumi Tamai; A Tsuji
Degradation kinetics of (+/-)-4'-ethyl-2-methyl-3-(1-pyrrolidinyl)propiophenone hydrochloride (HY-770) and structure-stability relationship among its analogues in aqueous solution.
Journal of pharmaceutical sciences 1989;78(1):57-61.
1988: Ikumi Tamai; A Tsuji; Y Kin
Carrier-mediated transport of cefixime, a new cephalosporin antibiotic, via an organic anion transport system in the rat renal brush-border membrane.
The Journal of pharmacology and experimental therapeutics 1988;246(1):338-44.
1988: Y Deguchi; E Nakashima; F Ishikawa; H Sato; Ikumi Tamai; R Matsushita; Y Tofuku; F Ichimura; A Tsuji
Peritoneal transport of beta-lactam antibiotics: effects of plasma protein binding and the interspecies relationship.
Journal of pharmaceutical sciences 1988;77(7):559-64.
1988: E Nakashima; F Ishikawa; H Sato; Y Deguchi; Ikumi Tamai; R Matsushita; F Ichimura; A Tsuji
Kinetics of peritoneal drug transport in rats: an application of the pore theory of transcapillary exchange.
Journal of pharmaceutical sciences 1988;77(6):481-8.
1988: Ikumi Tamai; H Y Ling; S M Timbul; J Nishikido; A Tsuji
Stereospecific absorption and degradation of cephalexin.
The Journal of pharmacy and pharmacology 1988;40(5):320-4.
1988: A Tsuji; H Sato; Y Kume; Ikumi Tamai; Eiichi Okezaki; O Nagata; H Kato
Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes.
Antimicrobial agents and chemotherapy 1988;32(2):190-4.
1987: Ikumi Tamai; A Tsuji
Transport mechanism of cephalexin in isolated hepatocytes.
Journal of pharmacobio-dynamics 1987;10(11):632-8.