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Fuyuhiko Tamanoi

This is a preview profile on BiomedExperts - the first literature-based scientific social network. It brings the right researchers together and allows them to collaborate online. Collexis and Dell provide the BiomedExperts network of +1.5 Million pre-calculated profiles free of charge to researchers worldwide.

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Co-Publications
Name
13
Urano, Jun
10
Guo, Lea
8
Gau, Chia-Ling
7
Kato-Stankiewicz, Juran
6
Del Villar, K
6
Fujiyama, Asao
5
Yang, W
4
Aspuria, Paul-Joseph
4
Edamatsu, Hironori
4
Tabancay, Angel
3
Patel, Parthive
3
Cannon, John
3
Gelb, Michael
3
Jiang, Chen
3
Zink, Jeffrey

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Publications

TOP 3
Sato Tatsuhiro; Nakashima Akio; Guo Lea; Tamanoi Fuyuhiko
Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
Zhou Jun; Vos Chantal Chanel; Gjyrezi Ada; Yoshida Minoru; Khuri Fadlo R; Tamanoi Fuyuhiko; Giannakakou Paraskevi
The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.
Liong Monty; Lu Jie; Kovochich Michael; Xia Tian; Ruehm Stefan G; Nel Andre E; Tamanoi Fuyuhiko; Zink Jeffrey I
Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.

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All Publications

2009: Sato Tatsuhiro; Nakashima Akio; Guo Lea; Tamanoi Fuyuhiko
Specific activation of mTORC1 by Rheb G-protein in vitro involves enhanced recruitment of its substrate protein.
The Journal of biological chemistry 2009;284(19):12783-91.
2009: Zhou Jun; Vos Chantal Chanel; Gjyrezi Ada; Yoshida Minoru; Khuri Fadlo R; Tamanoi Fuyuhiko; Giannakakou Paraskevi
The protein farnesyltransferase regulates HDAC6 activity in a microtubule-dependent manner.
The Journal of biological chemistry 2009;284(15):9648-55.
2008: Liong Monty; Lu Jie; Kovochich Michael; Xia Tian; Ruehm Stefan G; Nel Andre E; Tamanoi Fuyuhiko; Zink Jeffrey I
Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.
ACS nano 2008;2(5):889-96.
2008: Aspuria Paul-Joseph; Tamanoi Fuyuhiko
The Tsc/Rheb signaling pathway controls basic amino acid uptake via the Cat1 permease in fission yeast.
Molecular genetics and genomics : MGG 2008;279(5):441-50.
2008: Lu Jie; Choi Eunshil; Tamanoi Fuyuhiko; Zink Jeffrey I
Light-activated nanoimpeller-controlled drug release in cancer cells.
Small (Weinheim an der Bergstrasse, Germany) 2008;4(4):421-6.
2008: Watanabe Masaru; Fiji Hannah D G; Guo Lea; Chan Lai; Kinderman Sape S; Slamon Dennis J; Kwon Ohyun; Tamanoi Fuyuhiko
Inhibitors of protein geranylgeranyltransferase I and Rab geranylgeranyltransferase identified from a library of allenoate-derived compounds.
The Journal of biological chemistry 2008;283(15):9571-9.
2008: Ikeda Kyoko; Morigasaki Susumu; Tatebe Hisashi; Tamanoi Fuyuhiko; Shiozaki Kazuhiro
Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control.
Cell cycle (Georgetown, Tex.) 2008;7(3):358-64.
2008: Sato Tatsuhiro; Umetsu Akiko; Tamanoi Fuyuhiko
Characterization of the Rheb-mTOR signaling pathway in mammalian cells: constitutive active mutants of Rheb and mTOR.
Methods in enzymology 2008;438():307-20.
2007: Lu Jie; Liong Monty; Zink Jeffrey I; Tamanoi Fuyuhiko
Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs.
Small (Weinheim an der Bergstrasse, Germany) 2007;3(8):1341-6.
2007: Aspuria Paul-Joseph; Sato Tatsuhiro; Tamanoi Fuyuhiko
The TSC/Rheb/TOR signaling pathway in fission yeast and mammalian cells: temperature sensitive and constitutive active mutants of TOR.
Cell cycle (Georgetown, Tex.) 2007;6(14):1692-5.
2007: Castellano Sabrina; Fiji Hannah D G; Kinderman Sape S; Watanabe Masaru; Leon Pablo de; Tamanoi Fuyuhiko; Kwon Ohyun
Small-molecule inhibitors of protein geranylgeranyltransferase type I.
Journal of the American Chemical Society 2007;129(18):5843-5.
2007: Matsuo Tomohiko; Otsubo Yoko; Urano Jun; Tamanoi Fuyuhiko; Yamamoto Masayuki
Loss of the TOR kinase Tor2 mimics nitrogen starvation and activates the sexual development pathway in fission yeast.
Molecular and cellular biology 2007;27(8):3154-64.
2007: Yu Fuqu; Harada Josephine N; Brown Helen J; Deng Hongyu; Song Moon Jung; Wu Ting-Ting; Kato-Stankiewicz Juran; Nelson Christian G; Vieira Jeffrey; Tamanoi Fuyuhiko; Chanda Sumit K; Sun Ren
Systematic identification of cellular signals reactivating Kaposi sarcoma-associated herpesvirus.
PLoS pathogens 2007;3(3):e44.
2007: Urano Jun; Sato Tatsuhiro; Matsuo Tomohiko; Otsubo Yoko; Yamamoto Masayuki; Tamanoi Fuyuhiko
Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells.
Proceedings of the National Academy of Sciences of the United States of America 2007;104(9):3514-9.
2006: Patel Parthive H; Tamanoi Fuyuhiko
Increased Rheb-TOR signaling enhances sensitivity of the whole organism to oxidative stress.
Journal of cell science 2006;119(Pt 20):4285-92.
2006: Gelb Michael H; Brunsveld Lucas; Hrycyna Christine A; Michaelis Susan; Tamanoi Fuyuhiko; Van Voorhis Wesley C; Waldmann Herbert
Therapeutic intervention based on protein prenylation and associated modifications.
Nature chemical biology 2006;2(10):518-28.
2006: Khazak Vladimir; Kato-Stankiewicz Juran; Tamanoi Fuyu; Golemis Erica A
Yeast screens for inhibitors of Ras-Raf interaction and characterization of MCP inhibitors of Ras-Raf interaction.
Methods in enzymology 2006;407():612-29.
2006: Patel Parthive H; Tamanoi Fuyuhiko
Using Drosophila and yeast genetics to investigate a role for the Rheb GTPase in cell growth.
Methods in enzymology 2006;407():443-54.
2005: Urano Jun; Comiso Melissa J; Guo Lea; Aspuria Paul-Joseph; Deniskin Roman; Tabancay Angel P; Kato-Stankiewicz Juran; Tamanoi Fuyuhiko
Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast.
Molecular microbiology 2005;58(4):1074-86.
2005: Gau Chia-Ling; Kato-Stankiewicz Juran; Jiang Chen; Miyamoto Susie; Guo Lea; Tamanoi Fuyuhiko
Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways.
Molecular cancer therapeutics 2005;4(6):918-26.
2004: Aspuria Paul-Joseph; Tamanoi Fuyuhiko
The Rheb family of GTP-binding proteins.
Cellular signalling 2004;16(10):1105-12.
2004: Kho Yoonjung; Kim Sung Chan; Jiang Chen; Barma Deb; Kwon Sung Won; Cheng Jinke; Jaunbergs Janis; Weinbaum Carolyn; Tamanoi Fuyuhiko; Falck John; Zhao Yingming
A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.
Proceedings of the National Academy of Sciences of the United States of America 2004;101(34):12479-84.
2004: Uhlmann Erik J; Li Wen; Scheidenhelm Danielle K; Gau Chia-Ling; Tamanoi Fuyuhiko; Gutmann David H
Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation.
Glia 2004;47(2):180-8.
2004: Clarke Steven; Tamanoi Fuyuhiko
Fighting cancer by disrupting C-terminal methylation of signaling proteins.
The Journal of clinical investigation 2004;113(4):513-5.
2003: Tabancay Angel P; Gau Chia-Ling; Machado Iara M P; Uhlmann Erik J; Gutmann David H; Guo Lea; Tamanoi Fuyuhiko
Identification of dominant negative mutants of Rheb GTPase and their use to implicate the involvement of human Rheb in the activation of p70S6K.
The Journal of biological chemistry 2003;278(41):39921-30.
2003: Patel Parthive H; Thapar Nitika; Guo Lea; Martinez Monica; Maris John; Gau Chia-Ling; Lengyel Judith A; Tamanoi Fuyuhiko
Drosophila Rheb GTPase is required for cell cycle progression and cell growth.
Journal of cell science 2003;116(Pt 17):3601-10.
2003: Hamasaki Akiyuki; Naka Hayato; Tamanoi Fuyuhiko; Umezawa Kazuo; Otsuka Masami
A novel metal-chelating inhibitor of protein farnesyltransferase.
Bioorganic & medicinal chemistry letters 2003;13(9):1523-6.
2002: Kato-Stankiewicz Juran; Hakimi Irina; Zhi Gang; Zhang Jie; Serebriiskii Ilya; Guo Lea; Edamatsu Hironori; Koide Hiroshi; Menon Sanjay; Eckl Robert; Sakamuri Sukumar; Lu Yingchun; Chen Quin-Zene; Agarwal Seema; Baumbach William R; Golemis Erica A; Tamanoi Fuyuhiko; Khazak Vladimir
Inhibitors of Ras/Raf-1 interaction identified by two-hybrid screening revert Ras-dependent transformation phenotypes in human cancer cells.
Proceedings of the National Academy of Sciences of the United States of America 2002;99(22):14398-403.
2001: Finlin B S; Gau C L; Murphy G A; Shao H; Kimel T; Seitz R S; Chiu Y F; Botstein D; Brown P O; Der C J; Tamanoi F; Andres D A; Perou C M
RERG is a novel ras-related, estrogen-regulated and growth-inhibitory gene in breast cancer.
The Journal of biological chemistry 2001;276(45):42259-67.
2001: Tamanoi F; Gau C L; Jiang C; Edamatsu H; Kato-Stankiewicz J
Protein farnesylation in mammalian cells: effects of farnesyltransferase inhibitors on cancer cells.
Cellular and molecular life sciences : CMLS 2001;58(11):1636-49.
2001: Yang W; Tabancay A P; Urano J; Tamanoi F
Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant.
Molecular microbiology 2001;41(6):1339-47.
2001: Pervin S; Singh R; Gau C L; Edamatsu H; Tamanoi F; Chaudhuri G
Potentiation of nitric oxide-induced apoptosis of MDA-MB-468 cells by farnesyltransferase inhibitor: implications in breast cancer.
Cancer research 2001;61(12):4701-6.
2001: Tamanoi F; Kato-Stankiewicz J; Jiang C; Machado I; Thapar N
Farnesylated proteins and cell cycle progression.
Journal of cellular biochemistry. Supplement 2001;Suppl 37():64-70.
2001: Urano J; Ellis C; Clark G J; Tamanoi F
Characterization of Rheb functions using yeast and mammalian systems.
Methods in enzymology 2001;333():217-31.
2000: Edamatsu H; Gau C L; Nemoto T; Guo L; Tamanoi F
Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines.
Oncogene 2000;19(27):3059-68.
2000: Urano J; Tabancay A P; Yang W; Tamanoi F
The Saccharomyces cerevisiae Rheb G-protein is involved in regulating canavanine resistance and arginine uptake.
The Journal of biological chemistry 2000;275(15):11198-206.
2000: Yang W; Urano J; Tamanoi F
Protein farnesylation is critical for maintaining normal cell morphology and canavanine resistance in Schizosaccharomyces pombe.
The Journal of biological chemistry 2000;275(1):429-38.
1999: Del Villar K; Urano J; Guo L; Tamanoi F
A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors.
The Journal of biological chemistry 1999;274(38):27010-7.
1999: Robinson N G; Guo L; Imai J; Toh-E A; Matsui Y; Tamanoi F
Rho3 of Saccharomyces cerevisiae, which regulates the actin cytoskeleton and exocytosis, is a GTPase which interacts with Myo2 and Exo70.
Molecular and cellular biology 1999;19(5):3580-7.
1999: Urano J; Tamanoi F
Reconstitution of yeast farnesyltransferase from individually purified subunits.
Methods in molecular biology (Clifton, N.J.) 1999;116():145-59.
1998: Suzuki N; Urano J; Tamanoi F
Farnesyltransferase inhibitors induce cytochrome c release and caspase 3 activation preferentially in transformed cells.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(26):15356-61.
1998: Suzuki N; Del Villar K; Tamanoi F
Farnesyltransferase inhibitors induce dramatic morphological changes of KNRK cells that are blocked by microtubule interfering agents.
Proceedings of the National Academy of Sciences of the United States of America 1998;95(18):10499-504.
1998: Scoles D R; Huynh D P; Morcos P A; Coulsell E R; Robinson N G; Tamanoi F; Pulst S M
Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin.
Nature genetics 1998;18(4):354-9.
1997: Del Villar K; Mitsuzawa H; Yang W; Sattler I; Tamanoi F
Amino acid substitutions that convert the protein substrate specificity of farnesyltransferase to that of geranylgeranyltransferase type I.
The Journal of biological chemistry 1997;272(1):680-7.
1997: Yang W; Del Villar K; Urano J; Mitsuzawa H; Tamanoi F
Advances in the development of farnesyltransferase inhibitors: substrate recognition by protein farnesyltransferase.
Journal of cellular biochemistry. Supplement 1997;27():12-9.
1996: Del Villar K; Dorin D; Sattler I; Urano J; Poullet P; Robinson N; Mitsuzawa H; Tamanoi F
C-terminal motifs found in Ras-superfamily G-proteins: CAAX and C-seven motifs.
Biochemical Society transactions 1996;24(3):709-13.
1996: Morcos P; Thapar N; Tusneem N; Stacey D; Tamanoi F
Identification of neurofibromin mutants that exhibit allele specificity or increased Ras affinity resulting in suppression of activated ras alleles.
Molecular and cellular biology 1996;16(5):2496-503.
1995: Dorin D; Cohen L; Del Villar K; Poullet P; Mohr R; Whiteway M; Witte O; Tamanoi F
Kir, a novel Ras-family G-protein, induces invasive pseudohyphal growth in Saccharomyces cerevisiae.
Oncogene 1995;11(11):2267-71.
1995: Baba H; Fuss B; Urano J; Poullet P; Watson J B; Tamanoi F; Macklin W B
GapIII, a new brain-enriched member of the GTPase-activating protein family.
Journal of neuroscience research 1995;41(6):846-58.
1995: Gelb M H; Tamanoi F; Yokoyama K; Ghomashchi F; Esson K; Gould M N
The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol.
Cancer letters 1995;91(2):169-75.
1995: Mitsuzawa H; Esson K; Tamanoi F
Mutant farnesyltransferase beta subunit of Saccharomyces cerevisiae that can substitute for geranylgeranyltransferase type I beta subunit.
Proceedings of the National Academy of Sciences of the United States of America 1995;92(5):1704-8.
1995: Tamanoi F; Mitsuzawa H
Use of yeast for identification of farnesyltransferase inhibitors and for generation of mutant farnesyltransferases.
Methods in enzymology 1995;255():82-91.
1995: Poullet P; Tamanoi F
Use of yeast two-hybrid system to evaluate Ras interactions with neurofibromin-GTPase-activating protein.
Methods in enzymology 1995;255():488-97.
1995: Mitsuzawa H; Tamanoi F
In vivo assays for farnesyltransferase inhibitors with Saccharomyces cerevisiae.
Methods in enzymology 1995;250():43-51.
1994: Cohen L; Mohr R; Chen Y Y; Huang M; Kato R; Dorin D; Tamanoi F; Goga A; Afar D; Rosenberg N
Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases.
Proceedings of the National Academy of Sciences of the United States of America 1994;91(26):12448-52.
1994: Wood D R; Poullet P; Wilson B A; Khalil M; Tanaka K; Cannon J F; Tamanoi F
Biochemical characterization of yeast RAS2 mutants reveals a new region of ras protein involved in the interaction with GTPase-activating proteins.
The Journal of biological chemistry 1994;269(7):5322-7.
1994: Poullet P; Lin B; Esson K; Tamanoi F
Functional significance of lysine 1423 of neurofibromin and characterization of a second site suppressor which rescues mutations at this residue and suppresses RAS2Val-19-activated phenotypes.
Molecular and cellular biology 1994;14(1):815-21.
1993: Wilson B A; Khalil M; Tamanoi F; Cannon J F
New activated RAS2 mutations identified in Saccharomyces cerevisiae.
Oncogene 1993;8(12):3441-5.
1993: Tamanoi F
Inhibitors of Ras farnesyltransferases.
Trends in biochemical sciences 1993;18(9):349-53.
1993: Gomez R; Goodman L E; Tripathy S K; O'Rourke E; Manne V; Tamanoi F
Purified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart.
The Biochemical journal 1993;289 ( Pt 1)():25-31.
1992: Tanaka K; Wood D R; Lin B K; Khalil M; Tamanoi F; Cannon J F
A dominant activating mutation in the effector region of RAS abolishes IRA2 sensitivity.
Molecular and cellular biology 1992;12(2):631-7.
1991: McNeel D G; Tamanoi F
Terminal region recognition factor 1, a DNA-binding protein recognizing the inverted terminal repeats of the pGKl linear DNA plasmids.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(24):11398-402.
1991: Fujiyama A; Tsunasawa S; Tamanoi F; Sakiyama F
S-farnesylation and methyl esterification of C-terminal domain of yeast RAS2 protein prior to fatty acid acylation.
The Journal of biological chemistry 1991;266(27):17926-31.
1991: Ohya Y; Goebl M; Goodman L E; Petersen-Bjørn S; Friesen J D; Tamanoi F; Anraku Y
Yeast CAL1 is a structural and functional homologue to the DPR1 (RAM) gene involved in ras processing.
The Journal of biological chemistry 1991;266(19):12356-60.
1991: Finegold A A; Johnson D I; Farnsworth C C; Gelb M H; Judd S R; Glomset J A; Tamanoi F
Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(10):4448-52.
1991: Tanaka K; Lin B K; Wood D R; Tamanoi F
IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase-activating protein.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):468-72.
1990: Goodman L E; Judd S R; Farnsworth C C; Powers S; Gelb M H; Glomset J A; Tamanoi F
Mutants of Saccharomyces cerevisiae defective in the farnesylation of Ras proteins.
Proceedings of the National Academy of Sciences of the United States of America 1990;87(24):9665-9.
1990: Finegold A A; Schafer W R; Rine J; Whiteway M; Tamanoi F
Common modifications of trimeric G proteins and ras protein: involvement of polyisoprenylation.
Science (New York, N.Y.) 1990;249(4965):165-9.
1990: Fujiyama A; Tamanoi F
RAS2 protein of Saccharomyces cerevisiae undergoes removal of methionine at N terminus and removal of three amino acids at C terminus.
The Journal of biological chemistry 1990;265(6):3362-8.
1989: Cobitz A R; Yim E H; Brown W R; Perou C M; Tamanoi F
Phosphorylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1989;86(3):858-62.
1988: Goodman L E; Perou C M; Fujiyama A; Tamanoi F
Structure and expression of yeast DPR1, a gene essential for the processing and intracellular localization of ras proteins.
Yeast (Chichester, England) 1988;4(4):271-81.
1988: Tamanoi F; Hsueh E C; Goodman L E; Cobitz A R; Detrick R J; Brown W R; Fujiyama A
Posttranslational modification of ras proteins: detection of a modification prior to fatty acid acylation and cloning of a gene responsible for the modification.
Journal of cellular biochemistry 1988;36(3):261-73.
1986: Fujiyama A; Tamanoi F
Processing and fatty acid acylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae.
Proceedings of the National Academy of Sciences of the United States of America 1986;83(5):1266-70.
1985: Broek D; Samiy N; Fasano O; Fujiyama A; Tamanoi F; Northup J; Wigler M
Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins.
Cell 1985;41(3):763-9.
1984: Fasano O; Aldrich T; Tamanoi F; Taparowsky E; Furth M; Wigler M
Analysis of the transforming potential of the human H-ras gene by random mutagenesis.
Proceedings of the National Academy of Sciences of the United States of America 1984;81(13):4008-12.

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