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Markku Tammi

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Sanna Pasonen-Seppänen; Leena Rauhala; Kirsi Rilla; Piia Takabe; Markku Tammi; Michael Edward; Raija Tammi
Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K-AKT and p38 signaling.
Reijo K Sironen; Markku Tammi; Raija Tammi; P K Auvinen; Maarit Anttila; V-M Kosma
Hyaluronan in human malignancies.
Simo O Syrjälä; Mikko A I Keränen; Raimo Tuuminen; Antti I Nykänen; Markku Tammi; Rainer Krebs; Karl B Lemström
Increased Th17 rather than Th1 alloimmune response is associated with cardiac allograft vasculopathy after hypothermic preservation in the rat.

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All Publications

2012: Sanna Pasonen-Seppänen; Leena Rauhala; Kirsi Rilla; Piia Takabe; Markku Tammi; Michael Edward; Raija Tammi
Melanoma cell-derived factors stimulate hyaluronan synthesis in dermal fibroblasts by upregulating HAS2 through PDGFR-PI3K-AKT and p38 signaling.
Histochemistry and cell biology 2012;138(6):895-911.
2011: Reijo K Sironen; Markku Tammi; Raija Tammi; P K Auvinen; Maarit Anttila; V-M Kosma
Hyaluronan in human malignancies.
Experimental cell research 2011;317(4):383-91.
2010: Simo O Syrjälä; Mikko A I Keränen; Raimo Tuuminen; Antti I Nykänen; Markku Tammi; Rainer Krebs; Karl B Lemström
Increased Th17 rather than Th1 alloimmune response is associated with cardiac allograft vasculopathy after hypothermic preservation in the rat.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010;29(9):1047-57.
2009: Anne Kultti; Sanna Pasonen-Seppänen; Marjo Jauhiainen; Kirsi J Rilla; Riikka Kärnä; Emma Pyöriä; Raija Tammi; Markku Tammi
4-Methylumbelliferone inhibits hyaluronan synthesis by depletion of cellular UDP-glucuronic acid and downregulation of hyaluronan synthase 2 and 3.
Experimental cell research 2009;315(11):1914-23.
2009: S Hartmann-Petersen; Raija Tammi; Markku Tammi; Veli-Matti Kosma
Depletion of cell surface CD44 in nonmelanoma skin tumours is associated with increased expression of matrix metalloproteinase 7.
The British journal of dermatology 2009;160(6):1251-7.
2008: Kirsi Rilla; Riikka Tiihonen; Anne Kultti; Markku Tammi; Raija Tammi
Pericellular hyaluronan coat visualized in live cells with a fluorescent probe is scaffolded by plasma membrane protrusions.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2008;56(10):901-10.
2008: Sanna M Pasonen-Seppänen; Edward V Maytin; Kari Törrönen; Juha M T Hyttinen; Vincent C Hascall; DK MacCallum; Anne H Kultti; Tiina A Jokela; Markku Tammi; Raija Tammi
All-trans retinoic acid-induced hyaluronan production and hyperplasia are partly mediated by EGFR signaling in epidermal keratinocytes.
The Journal of investigative dermatology 2008;128(4):797-807.
2008: Tiina A Jokela; Marjo Jauhiainen; Seppo Auriola; Miia Kauhanen; Riikka Tiihonen; Markku Tammi; Raija Tammi
Mannose inhibits hyaluronan synthesis by down-regulation of the cellular pool of UDP-N-acetylhexosamines.
The Journal of biological chemistry 2008;283(12):7666-73.
2008: Tiina A Jokela; Antti Lindgren; Kirsi Rilla; Edward V Maytin; Vincent C Hascall; Raija Tammi; Markku Tammi
Induction of hyaluronan cables and monocyte adherence in epidermal keratinocytes.
Connective tissue research 2008;49(3):115-9.
2007: Stephen P Evanko; Markku Tammi; Raija Tammi; Thomas N Wight
Hyaluronan-dependent pericellular matrix.
Advanced drug delivery reviews 2007;59(13):1351-65.
2007: Marjo Männistö; Mika Reinisalo; Marika Ruponen; Paavo Honkakoski; Markku Tammi; Arto Urtti
Polyplex-mediated gene transfer and cell cycle: effect of carrier on cellular uptake and intracellular kinetics, and significance of glycosaminoglycans.
The journal of gene medicine 2007;9(6):479-87.
2007: Katri Saavalainen; Markku Tammi; Timothy Bowen; M Lienhard Schmitz; Carsten Carlberg
Integration of the activation of the human hyaluronan synthase 2 gene promoter by common cofactors of the transcription factors retinoic acid receptor and nuclear factor kappaB.
The Journal of biological chemistry 2007;282(15):11530-9.
2007: Sari M Sillanpää; Maarit Anttila; Kirsi Voutilainen; Kirsi Ropponen; Taina Turpeenniemi-Hujanen; Ulla Puistola; Raija Tammi; Markku Tammi; Reijo K Sironen; Seppo Saarikoski; Veli-Matti Kosma
Prognostic significance of matrix metalloproteinase-9 (MMP-9) in epithelial ovarian cancer.
Gynecologic oncology 2007;104(2):296-303.
2007: Sari M Sillanpää; Maarit Anttila; K Suhonen; Kaisa Mari Hämäläinen; Taina Turpeenniemi-Hujanen; Ulla Puistola; Markku Tammi; Reijo K Sironen; Seppo Saarikoski; Veli-Matti Kosma
Prognostic significance of extracellular matrix metalloproteinase inducer and matrix metalloproteinase 2 in epithelial ovarian cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2007;28(5):280-9.
2006: Anne Kultti; Kirsi Rilla; Riikka Tiihonen; Andrew P Spicer; Raija Tammi; Markku Tammi
Hyaluronan synthesis induces microvillus-like cell surface protrusions.
The Journal of biological chemistry 2006;281(23):15821-8.
2005: Paivi Auvinen; Raija Tammi; Markku Tammi; Risto Johansson; Veli-Matti Kosma
Expression of CD 44 s, CD 44 v 3 and CD 44 v 6 in benign and malignant breast lesions: correlation and colocalization with hyaluronan.
Histopathology 2005;47(4):420-8.
2005: Kirsi Rilla; Hanna Siiskonen; Andrew P Spicer; Juha M T Hyttinen; Markku Tammi; Raija Tammi
Plasma membrane residence of hyaluronan synthase is coupled to its enzymatic activity.
The Journal of biological chemistry 2005;280(36):31890-7.
2005: Raija Tammi; Sanna Pasonen-Seppänen; Elina Kolehmainen; Markku Tammi
Hyaluronan synthase induction and hyaluronan accumulation in mouse epidermis following skin injury.
The Journal of investigative dermatology 2005;124(5):898-905.
2005: Katri Saavalainen; Sanna Pasonen-Seppänen; Thomas Dunlop; Raija Tammi; Markku Tammi; Carsten Carlberg
The human hyaluronan synthase 2 gene is a primary retinoic acid and epidermal growth factor responding gene.
The Journal of biological chemistry 2005;280(15):14636-44.
2005: Tarja Kemppainen; Raija Tammi; Markku Tammi; UM Agren; Risto Julkunen; Jan Böhm; Matti Uusitupa; Veli-Matti Kosma
Elevated expression of hyaluronan and its CD44 receptor in the duodenal mucosa of coeliac patients.
Histopathology 2005;46(1):64-72.
2004: Kirsi Rilla; Sanna Pasonen-Seppänen; Jarno Rieppo; Markku Tammi; Raija Tammi
The hyaluronan synthesis inhibitor 4-methylumbelliferone prevents keratinocyte activation and epidermal hyperproliferation induced by epidermal growth factor.
The Journal of investigative dermatology 2004;123(4):708-14.
2004: Marika Ruponen; Paavo Honkakoski; Markku Tammi; Arto Urtti
Cell-surface glycosaminoglycans inhibit cation-mediated gene transfer.
The journal of gene medicine 2004;6(4):405-14.
2004: Supaporn Suwiwat; Carmela Ricciardelli; Raija Tammi; Markku Tammi; Paivi Auvinen; Veli-Matti Kosma; Richard G LeBaron; Wendy A Raymond; Wayne D Tilley; David J Horsfall
Expression of extracellular matrix components versican, chondroitin sulfate, tenascin, and hyaluronan, and their association with disease outcome in node-negative breast cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2004;10(7):2491-8.
2004: Hanna Tuhkanen; Maarit Anttila; Veli-Matti Kosma; Seppo Ylä-Herttuala; Seppo Heinonen; Arja Kuronen; Matti Juhola; Raija Tammi; Markku Tammi; Arto Mannermaa
Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p.
International journal of cancer. Journal international du cancer 2004;109(2):247-52.
2004: Peter Teriete; Suneale Banerji; Martin Noble; Charles D Blundell; Alan J Wright; Andrew R Pickford; Edward D Lowe; David J Mahoney; Markku Tammi; Jan D Kahmann; Iain D Campbell; Anthony J Day; David G Jackson
Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44.
Molecular cell 2004;13(4):483-96.
2003: Marika Ruponen; Paavo Honkakoski; Seppo Rönkkö; Jukka Pelkonen; Markku Tammi; Arto Urtti
Extracellular and intracellular barriers in non-viral gene delivery.
Journal of controlled release : official journal of the Controlled Release Society 2003;93(2):213-7.
2003: Susanna Karvinen; Sanna Pasonen-Seppänen; Juha M T Hyttinen; Juha-Pekka Pienimäki; Kari Törrönen; Tiina A Jokela; Markku Tammi; Raija Tammi
Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3.
The Journal of biological chemistry 2003;278(49):49495-504.
2003: Kirsi Voutilainen; Maarit Anttila; Sari M Sillanpää; Raija Tammi; Markku Tammi; Seppo Saarikoski; Veli-Matti Kosma
Versican in epithelial ovarian cancer: relation to hyaluronan, clinicopathologic factors and prognosis.
International journal of cancer. Journal international du cancer 2003;107(3):359-64.
2003: Sari M Sillanpää; Maarit Anttila; Kirsi Voutilainen; Raija Tammi; Markku Tammi; Seppo V Saarikoski; Veli-Matti Kosma
CD44 expression indicates favorable prognosis in epithelial ovarian cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2003;9(14):5318-24.
2003: T Marjukka Suhonen; Sanna Pasonen-Seppänen; Merja Kirjavainen; Markku Tammi; Raija Tammi; Arto Urtti
Epidermal cell culture model derived from rat keratinocytes with permeability characteristics comparable to human cadaver skin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2003;20(1):107-13.
2003: Sanna Pasonen-Seppänen; Susanna Karvinen; Kari Törrönen; Juha M T Hyttinen; Tiina Jokela; Mikko Juhani Lammi; Markku Tammi; Raija Tammi
EGF upregulates, whereas TGF-beta downregulates, the hyaluronan synthases Has2 and Has3 in organotypic keratinocyte cultures: correlations with epidermal proliferation and differentiation.
The Journal of investigative dermatology 2003;120(6):1038-44.
2003: Susanna Karvinen; Veli-Matti Kosma; Markku Tammi; Raija Tammi
Hyaluronan, CD44 and versican in epidermal keratinocyte tumours.
The British journal of dermatology 2003;148(1):86-94.
2002: Essi L J Hiltunen; Maarit Anttila; Anne Kultti; Kirsi Ropponen; Jorma Penttinen; Merja Yliskoski; Arja Kuronen; Matti Juhola; Raija Tammi; Markku Tammi; Veli-Matti Kosma
Elevated hyaluronan concentration without hyaluronidase activation in malignant epithelial ovarian tumors.
Cancer research 2002;62(22):6410-3.
2002: Kirsi Rilla; Mikko Juhani Lammi; Reijo K Sironen; Kari Törrönen; Merja Luukkonen; Vincent C Hascall; Ronald J Midura; Mika M Hyttinen; Jukka Pelkonen; Markku Tammi; Raija Tammi
Changed lamellipodial extension, adhesion plaques and migration in epidermal keratinocytes containing constitutively expressed sense and antisense hyaluronan synthase 2 (Has2) genes.
Journal of cell science 2002;115(Pt 18):3633-43.
2002: Bryan P Toole; Thomas N Wight; Markku Tammi
Hyaluronan-cell interactions in cancer and vascular disease.
The Journal of biological chemistry 2002;277(7):4593-6.
2002: Markku Tammi; Anthony J Day; Eva A Turley
Hyaluronan and homeostasis: a balancing act.
The Journal of biological chemistry 2002;277(7):4581-4.
2002: Jan Böhm; Leo Niskanen; Raija Tammi; Markku Tammi; Matti Eskelinen; Risto Pirinen; Sinikka Hollmen; Esko Alhava; Veli-Matti Kosma
Hyaluronan expression in differentiated thyroid carcinoma.
The Journal of pathology 2002;196(2):180-5.
2001: Mika M Hyttinen; Jari P A Arokoski; Jyrki Parkkinen; Mikko Juhani Lammi; T Lapveteläinen; K Mauranen; K Király; Markku Tammi; Heikki J Helminen
Age matters: collagen birefringence of superficial articular cartilage is increased in young guinea-pigs but decreased in older animals after identical physiological type of joint loading.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 2001;9(8):694-701.
2001: Sanna Pasonen-Seppänen; TM Suhonen; Merja Kirjavainen; M Miettinen; Arto Urtti; Markku Tammi; Raija Tammi
Formation of permeability barrier in epidermal organotypic culture for studies on drug transport.
The Journal of investigative dermatology 2001;117(5):1322-4.
2001: Sanna Pasonen-Seppänen; TM Suhonen; Merja Kirjavainen; Eero Suihko; Arto Urtti; M Miettinen; Mika M Hyttinen; Markku Tammi; Raija Tammi
Vitamin C enhances differentiation of a continuous keratinocyte cell line (REK) into epidermis with normal stratum corneum ultrastructure and functional permeability barrier.
Histochemistry and cell biology 2001;116(4):287-97.
2001: Raija Tammi; Kirsi Rilla; J P Pienimaki; DK MacCallum; M Hogg; M Luukkonen; Vincent C Hascall; Markku Tammi
Hyaluronan enters keratinocytes by a novel endocytic route for catabolism.
The Journal of biological chemistry 2001;276(37):35111-22.
2001: Marika Ruponen; Seppo Rönkkö; Paavo Honkakoski; Jukka Pelkonen; Markku Tammi; Arto Urtti
Extracellular glycosaminoglycans modify cellular trafficking of lipoplexes and polyplexes.
The Journal of biological chemistry 2001;276(36):33875-80.
2001: J P Pienimaki; Kirsi Rilla; C Fulop; Reijo K Sironen; Susanna Karvinen; S Pasonen; Mikko Juhani Lammi; Raija Tammi; Vincent C Hascall; Markku Tammi
Epidermal growth factor activates hyaluronan synthase 2 in epidermal keratinocytes and increases pericellular and intracellular hyaluronan.
The Journal of biological chemistry 2001;276(23):20428-35.
2001: Pertti Lipponen; Sirpa Aaltomaa; Raija Tammi; Markku Tammi; UM Agren; Veli-Matti Kosma
High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer.
European journal of cancer (Oxford, England : 1990) 2001;37(7):849-56.
2001: Risto Pirinen; Raija Tammi; Markku Tammi; Pasi Hirvikoski; Jyrki Parkkinen; Risto Johansson; Jan Böhm; SM Hollmén; Veli-Matti Kosma
Prognostic value of hyaluronan expression in non-small-cell lung cancer: Increased stromal expression indicates unfavorable outcome in patients with adenocarcinoma.
International journal of cancer. Journal international du cancer 2001;95(1):12-7.
2001: Jari P A Arokoski; Mikko Juhani Lammi; Mika M Hyttinen; Ilkka Kiviranta; Jyrki Parkkinen; J S Jurvelin; Markku Tammi; Heikki J Helminen
[Etiopathogenesis of osteoarthritis].
Duodecim; lääketieteellinen aikakauskirja 2001;117(16):1617-26; quiz 1626, 1679.
2001: Leena P Setälä; Pertti Lipponen; Raija Tammi; Markku Tammi; Matti Eskelinen; Esko Alhava; Veli-Matti Kosma
Expression of CD44 and its variant isoform v3 has no prognostic value in gastric cancer.
Histopathology 2001;38(1):13-20.
2001: J Haapala; Jari P A Arokoski; Seppo Rönkkö; UM Agren; Veli-Matti Kosma; LS Lohmander; Markku Tammi; Heikki J Helminen; Ilkka Kiviranta
Decline after immobilisation and recovery after remobilisation of synovial fluid IL1, TIMP, and chondroitin sulphate levels in young beagle dogs.
Annals of the rheumatic diseases 2001;60(1):55-60.
2000: JM Karjalainen; Raija Tammi; Markku Tammi; Matti Eskelinen; UM Agren; Jyrki Parkkinen; Esko M Alhava; Veli-Matti Kosma
Reduced level of CD44 and hyaluronan associated with unfavorable prognosis in clinical stage I cutaneous melanoma.
The American journal of pathology 2000;157(3):957-65.
2000: Raija Tammi; Markku Tammi; Vincent C Hascall; M Hogg; S Pasonen; DK MacCallum
A preformed basal lamina alters the metabolism and distribution of hyaluronan in epidermal keratinocyte "organotypic" cultures grown on collagen matrices.
Histochemistry and cell biology 2000;113(4):265-77.
2000: M O Jortikka; Jyrki Parkkinen; RI Inkinen; J Kärner; Hannu Järveläinen; Lassi Nelimarkka; Markku Tammi; Mikko Juhani Lammi
The role of microtubules in the regulation of proteoglycan synthesis in chondrocytes under hydrostatic pressure.
Archives of biochemistry and biophysics 2000;374(2):172-80.
2000: Paivi Auvinen; Raija Tammi; Jyrki Parkkinen; Markku Tammi; UM Agren; Risto Johansson; Pasi Hirvikoski; Matti Eskelinen; Veli-Matti Kosma
Hyaluronan in peritumoral stroma and malignant cells associates with breast cancer spreading and predicts survival.
The American journal of pathology 2000;156(2):529-36.
2000: Heikki J Helminen; Mika M Hyttinen; Mikko Juhani Lammi; Jari P A Arokoski; T Lapveteläinen; Jukka S Jurvelin; Ilkka Kiviranta; Markku Tammi
Regular joint loading in youth assists in the establishment and strengthening of the collagen network of articular cartilage and contributes to the prevention of osteoarthrosis later in life: a hypothesis.
Journal of bone and mineral metabolism 2000;18(5):245-57.
2000: J Haapala; Jari P A Arokoski; J Pirttimäki; T Lyyra; Jukka S Jurvelin; Markku Tammi; Heikki J Helminen; Ilkka Kiviranta
Incomplete restoration of immobilization induced softening of young beagle knee articular cartilage after 50-week remobilization.
International journal of sports medicine 2000;21(1):76-81.
2000: Maarit Anttila; Raija Tammi; Markku Tammi; Kari Juhani Syrjänen; Seppo V Saarikoski; Veli-Matti Kosma
High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer.
Cancer research 2000;60(1):150-5.
1999: AL Tuhkanen; UM Agren; Markku Tammi; Raija Tammi
CD44 expression marks the onset of keratinocyte stratification and mesenchymal maturation into fibrous dermis in fetal human skin.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1999;47(12):1617-24.
1999: RI Inkinen; Mikko Juhani Lammi; UM Agren; Raija Tammi; Kaija Puustjärvi; Markku Tammi
Hyaluronan distribution in the human and canine intervertebral disc and cartilage endplate.
The Histochemical journal 1999;31(9):579-87.
1999: J Haapala; Jari P A Arokoski; Mika M Hyttinen; Mikko Juhani Lammi; Markku Tammi; Vuokko Kovanen; Heikki J Helminen; Ilkka Kiviranta
Remobilization does not fully restore immobilization induced articular cartilage atrophy.
Clinical orthopaedics and related research 1999;(362):218-29.
1999: Leena P Setälä; Markku Tammi; Raija Tammi; Matti Eskelinen; Pertti Lipponen; UM Agren; Jyrki Parkkinen; Esko M Alhava; Veli-Matti Kosma
Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate.
British journal of cancer 1999;79(7-8):1133-8.
1999: Pasi Hirvikoski; Raija Tammi; Eero J Kumpulainen; Jukka Virtaniemi; Jyrki Parkkinen; Markku Tammi; Risto Johansson; UM Agren; J Karhunen; Veli-Matti Kosma
Irregular expression of hyaluronan and its CD44 receptor is associated with metastatic phenotype in laryngeal squamous cell carcinoma.
Virchows Archiv : an international journal of pathology 1999;434(1):37-44.
1998: Raija Tammi; DK MacCallum; Vincent C Hascall; J P Pienimäki; Mika M Hyttinen; Markku Tammi
Hyaluronan bound to CD44 on keratinocytes is displaced by hyaluronan decasaccharides and not hexasaccharides.
The Journal of biological chemistry 1998;273(44):28878-88.
1998: Risto Pirinen; Raija Tammi; Markku Tammi; P K Pääkkö; Jyrki Parkkinen; UM Agren; Risto T Johansson; M M Viren; Ulla Näpänkangas; Y M Soini; Veli-Matti Kosma
Expression of hyaluronan in normal and dysplastic bronchial epithelium and in squamous cell carcinoma of the lung.
International journal of cancer. Journal international du cancer 1998;79(3):251-5.
1998: U Väätäinen; LS Lohmander; E Thonar; T Hongisto; UM Agren; Seppo Rönkkö; H Jaroma; Veli-Matti Kosma; Markku Tammi; Ilkka Kiviranta
Markers of cartilage and synovial metabolism in joint fluid and serum of patients with chondromalacia of the patella.
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society 1998;6(2):115-24.
1998: RI Inkinen; Mikko Juhani Lammi; S Lehmonen; Kaija Puustjärvi; E Kääpä; Markku Tammi
Relative increase of biglycan and decorin and altered chondroitin sulfate epitopes in the degenerating human intervertebral disc.
The Journal of rheumatology 1998;25(3):506-14.
1998: U Väätäinen; Ilkka Kiviranta; H Jaroma; J Arokosi; Markku Tammi; Vuokko Kovanen
Collagen crosslinks in chondromalacia of the patella.
International journal of sports medicine 1998;19(2):144-8.
1998: AL Tuhkanen; Markku Tammi; Alpo Pelttari; UM Agren; Raija Tammi
Ultrastructural analysis of human epidermal CD44 reveals preferential distribution on plasma membrane domains facing the hyaluronan-rich matrix pouches.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1998;46(2):241-8.
1998: Kirsi Ropponen; Markku Tammi; Jyrki Parkkinen; Matti Eskelinen; Raija Tammi; Pertti Lipponen; UM Agren; Esko Alhava; Veli-Matti Kosma
Tumor cell-associated hyaluronan as an unfavorable prognostic factor in colorectal cancer.
Cancer research 1998;58(2):342-7.
1997: UM Agren; Markku Tammi; Markku Ryynänen; Raija Tammi
Developmentally programmed expression of hyaluronan in human skin and its appendages.
The Journal of investigative dermatology 1997;109(2):219-24.
1997: AL Tuhkanen; Markku Tammi; Raija Tammi
CD44 substituted with heparan sulfate and endo-beta-galactosidase-sensitive oligosaccharides: a major proteoglycan in adult human epidermis.
The Journal of investigative dermatology 1997;109(2):213-8.
1997: Jyrki Parkkinen; Mikko Juhani Lammi; UM Agren; Markku Tammi; Tuomo A Keinänen; T Hyvönen; T O Eloranta
Polyamine-dependent alterations in the structure of microfilaments, Golgi apparatus, endoplasmic reticulum, and proteoglycan synthesis in BHK cells.
Journal of cellular biochemistry 1997;66(2):165-74.
1997: M O Jortikka; RI Inkinen; Markku Tammi; Jyrki Parkkinen; J Haapala; Ilkka Kiviranta; Heikki J Helminen; Mikko Juhani Lammi
Immobilisation causes longlasting matrix changes both in the immobilised and contralateral joint cartilage.
Annals of the rheumatic diseases 1997;56(4):255-61.
1997: UM Agren; Raija Tammi; Markku Tammi
Reactive oxygen species contribute to epidermal hyaluronan catabolism in human skin organ culture.
Free radical biology & medicine 1997;23(7):996-1001.
1996: J Haapala; Mikko Juhani Lammi; RI Inkinen; Jyrki Parkkinen; UM Agren; Jari P A Arokoski; Ilkka Kiviranta; Heikki J Helminen; Markku Tammi
Coordinated regulation of hyaluronan and aggrecan content in the articular cartilage of immobilized and exercised dogs.
The Journal of rheumatology 1996;23(9):1586-93.
1996: Jyrki Parkkinen; Tomi P Häkkinen; S Savolainen; C Wang; Raija Tammi; UM Agren; Mikko Juhani Lammi; Jari P A Arokoski; Heikki J Helminen; Markku Tammi
Distribution of hyaluronan in articular cartilage as probed by a biotinylated binding region of aggrecan.
Histochemistry and cell biology 1996;105(3):187-94.
1996: K Király; Mikko Juhani Lammi; Jari P A Arokoski; T Lapveteläinen; Markku Tammi; Heikki J Helminen; Ilkka Kiviranta
Safranin O reduces loss of glycosaminoglycans from bovine articular cartilage during histological specimen preparation.
The Histochemical journal 1996;28(2):99-107.
1995: U Väätäinen; Tomi P Häkkinen; Ilkka Kiviranta; H Jaroma; RI Inkinen; Markku Tammi
Proteoglycan depletion and size reduction in lesions of early grade chondromalacia of the patella.
Annals of the rheumatic diseases 1995;54(10):831-5.
1995: UM Agren; Markku Tammi; Raija Tammi
Hydrocortisone regulation of hyaluronan metabolism in human skin organ culture.
Journal of cellular physiology 1995;164(2):240-8.
1995: Jyrki Parkkinen; Mikko Juhani Lammi; RI Inkinen; M Jortikka; Markku Tammi; I Virtanen; Heikki J Helminen
Influence of short-term hydrostatic pressure on organization of stress fibers in cultured chondrocytes.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1995;13(4):495-502.
1995: J Karppinen; RI Inkinen; Eeva Kääpä; Mikko Juhani Lammi; Markku Tammi; S Holm; H Vanharanta
Effects of tiaprofenic acid and indomethacin on proteoglycans in the degenerating porcine intervertebral disc.
Spine 1995;20(10):1170-7.
1995: Kaija Puustjärvi; R Lappalainen; L Niemitukia; I Arnala; J Nieminen; Markku Tammi; Heikki J Helminen
Long-distance running alters bone anthropometry, elemental composition and mineral density of young dogs.
Scandinavian journal of medicine & science in sports 1995;5(1):17-23.
1994: Mikko Juhani Lammi; RI Inkinen; Jyrki Parkkinen; Tomi P Häkkinen; M Jortikka; L O Nelimarkka; Hannu Järveläinen; Markku Tammi
Expression of reduced amounts of structurally altered aggrecan in articular cartilage chondrocytes exposed to high hydrostatic pressure.
The Biochemical journal 1994;304 ( Pt 3)():723-30.
1994: Raija Tammi; Seppo Rönkkö; UM Agren; Markku Tammi
Distribution of hyaluronan in bull reproductive organs.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 1994;42(11):1479-86.
1994: Eeva Kääpä; S Holm; RI Inkinen; Mikko Juhani Lammi; Markku Tammi; H Vanharanta
Proteoglycan chemistry in experimentally injured porcine intervertebral disk.
Journal of spinal disorders 1994;7(4):296-306.
1994: Jari P A Arokoski; Jukka S Jurvelin; Ilkka Kiviranta; Markku Tammi; Heikki J Helminen
Softening of the lateral condyle articular cartilage in the canine knee joint after long distance (up to 40 km/day) running training lasting one year.
International journal of sports medicine 1994;15(5):254-60.
1994: UM Agren; Raija Tammi; Markku Tammi
A dot-blot assay of metabolically radiolabeled hyaluronan.
Analytical biochemistry 1994;217(2):311-5.
1994: Ilkka Kiviranta; Markku Tammi; Jukka S Jurvelin; Jari P A Arokoski; Anna-Marja Säämänen; Heikki J Helminen
Articular cartilage thickness and glycosaminoglycan distribution in the young canine knee joint after remobilization of the immobilized limb.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1994;12(2):161-7.
1994: Kaija Puustjärvi; Mikko Juhani Lammi; Heikki J Helminen; RI Inkinen; Markku Tammi
Proteoglycans in the intervertebral disc of young dogs following strenuous running exercise.
Connective tissue research 1994;30(3):225-40.
1994: A M Säämämen; Ilkka Kiviranta; Jukka S Jurvelin; H J Helminen; Markku Tammi
Proteoglycan and collagen alterations in canine knee articular cartilage following 20 km daily running exercise for 15 weeks.
Connective tissue research 1994;30(3):191-201.
1994: Raija Tammi; UM Agren; A L Tuhkanen; Markku Tammi
Hyaluronan metabolism in skin.
Progress in histochemistry and cytochemistry 1994;29(2):1-81.
1994: Kaija Puustjärvi; Markku Tammi; M Reinikainen; Heikki J Helminen; L Paljärvi
Running training alters fiber type composition in spinal muscles.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 1994;3(1):17-21.
1994: Raija Tammi; K Paukkonen; C Wang; Maija Horsmanheimo; Markku Tammi
Hyaluronan and CD44 in psoriatic skin. Intense staining for hyaluronan on dermal capillary loops and reduced expression of CD44 and hyaluronan in keratinocyte-leukocyte interfaces.
Archives of dermatological research 1994;286(1):21-9.
1993: Kaija Puustjärvi; T Takala; W Wang; Markku Tammi; Heikki J Helminen; V Kovanen
Enhanced prolylhydroxylase activity in the posterior annulus fibrosus of canine intervertebral discs following long-term running exercise.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 1993;2(3):126-31.
1993: Jari P A Arokoski; Ilkka Kiviranta; Jukka S Jurvelin; Markku Tammi; Heikki J Helminen
Long-distance running causes site-dependent decrease of cartilage glycosaminoglycan content in the knee joints of beagle dogs.
Arthritis and rheumatism 1993;36(10):1451-9.
1993: Kaija Puustjärvi; Mikko Juhani Lammi; Ilkka Kiviranta; Heikki J Helminen; Markku Tammi
Proteoglycan synthesis in canine intervertebral discs after long-distance running training.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1993;11(5):738-46.
1993: Heikki J Helminen; K Kiraly; Alpo Pelttari; Markku Tammi; P Vandenberg; R Pereira; R Dhulipala; Jaspal Singh Khillan; Leena Ala-Kokko; Eric L Hume
An inbred line of transgenic mice expressing an internally deleted gene for type II procollagen (COL2A1). Young mice have a variable phenotype of a chondrodysplasia and older mice have osteoarthritic changes in joints.
The Journal of clinical investigation 1993;92(2):582-95.
1993: Mikko Juhani Lammi; Tomi P Häkkinen; Jyrki Parkkinen; Mika M Hyttinen; M Jortikka; Heikki J Helminen; Markku Tammi
Adaptation of canine femoral head articular cartilage to long distance running exercise in young beagles.
Annals of the rheumatic diseases 1993;52(5):369-77.
1993: Jyrki Parkkinen; Mikko Juhani Lammi; Alpo Pelttari; Heikki J Helminen; Markku Tammi; I Virtanen
Altered Golgi apparatus in hydrostatically loaded articular cartilage chondrocytes.
Annals of the rheumatic diseases 1993;52(3):192-8.
1993: Kaija Puustjärvi; Mikko Juhani Lammi; Ilkka Kiviranta; Heikki J Helminen; Markku Tammi
Flat bed scanner in the quantitative assay of 35SO4-incorporation by X-ray film autoradiography of intervertebral disc sections.
Histochemistry 1993;99(1):67-73.
1993: Mikko Juhani Lammi; Tomi P Häkkinen; Jyrki Parkkinen; Mika M Hyttinen; M Jortikka; Heikki J Helminen; Markku Tammi
Effects of long-term running exercise on canine femoral head articular cartilage.
Agents and actions. Supplements 1993;39():95-9.
1993: Anna-Marja Säämänen; Kaija Puustjärvi; K Ilves; Mikko Juhani Lammi; Ilkka Kiviranta; Jukka S Jurvelin; Heikki J Helminen; Markku Tammi
Effect of running exercise on proteoglycans and collagen content in the intervertebral disc of young dogs.
International journal of sports medicine 1993;14(1):48-51.
1993: Jyrki Parkkinen; J Ikonen; Mikko Juhani Lammi; J Laakkonen; Markku Tammi; Heikki J Helminen
Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants.
Archives of biochemistry and biophysics 1993;300(1):458-65.
1993: Jari P A Arokoski; P V Miettinen; Anna-Marja Säämänen; K Haapanen; Markku Parviainen; Markku Tammi; Heikki J Helminen
Effects of aerobic long distance running training (up to 40 km.day-1) of 1-year duration on blood and endocrine parameters of female beagle dogs.
European journal of applied physiology and occupational physiology 1993;67(4):321-9.
1993: M Jortikka; Mikko Juhani Lammi; Jyrki Parkkinen; R Lahtinen; Markku Tammi
A high sensitivity dot-blot assay for proteoglycans by cuprolinic blue precipitation.
Connective tissue research 1993;29(4):263-72.
1992: Anneli Martikainen; Markku Tammi; Raija Tammi
Proteoglycans synthesized by adult human epidermis in whole skin organ culture.
The Journal of investigative dermatology 1992;99(5):623-8.
1992: Ilkka Kiviranta; Markku Tammi; Jukka S Jurvelin; Jari P A Arokoski; Anna-Marja Säämänen; Heikki J Helminen
Articular cartilage thickness and glycosaminoglycan distribution in the canine knee joint after strenuous running exercise.
Clinical orthopaedics and related research 1992;(283):302-8.
1992: Jyrki Parkkinen; Mikko Juhani Lammi; Heikki J Helminen; Markku Tammi
Local stimulation of proteoglycan synthesis in articular cartilage explants by dynamic compression in vitro.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1992;10(5):610-20.
1992: C Wang; Markku Tammi; Raija Tammi
Distribution of hyaluronan and its CD44 receptor in the epithelia of human skin appendages.
Histochemistry 1992;98(2):105-12.
1992: Heikki J Helminen; Anna-Marja Säämänen; Jukka S Jurvelin; Ilkka Kiviranta; Jyrki Parkkinen; Mikko Juhani Lammi; Markku Tammi
[The effect of loading on articular cartilage].
Duodecim; lääketieteellinen aikakauskirja 1992;108(12):1097-107.
1991: Raija Tammi; Markku Tammi
Correlations between hyaluronan and epidermal proliferation as studied by [3H]glucosamine and [3H]thymidine incorporations and staining of hyaluronan on mitotic keratinocytes.
Experimental cell research 1991;195(2):524-7.
1991: Raija Tammi; Anna-Marja Säämänen; H I Maibach; Markku Tammi
Degradation of newly synthesized high molecular mass hyaluronan in the epidermal and dermal compartments of human skin in organ culture.
The Journal of investigative dermatology 1991;97(1):126-30.
1991: Jari P A Arokoski; Ilkka Kiviranta; J Laakkonen; A Tiihonen; E Sopanen; J Ikonen; Tapio Nevalainen; K Haapanen; Markku Tammi; Heikki J Helminen
A ten-track treadmill for running training of dogs.
Laboratory animal science 1991;41(3):246-50.
1991: Mikko Juhani Lammi; Markku Tammi
Autoradiographic quantitation of radiolabeled proteoglycans.
Journal of biochemical and biophysical methods 1991;22(4):301-10.
1990: Anna-Marja Säämänen; Markku Tammi; Jukka S Jurvelin; Ilkka Kiviranta; Heikki J Helminen
Proteoglycan alterations following immobilization and remobilization in the articular cartilage of young canine knee (stifle) joint.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1990;8(6):863-73.
1990: Jyrki Parkkinen; K Paukkonen; E Pesonen; Mikko Juhani Lammi; S Markkanen; Heikki J Helminen; Markku Tammi
Quantitation of autoradiographic grains in different zones of articular cartilage with image analyzer.
Histochemistry 1990;93(3):241-5.
1990: Jukka S Jurvelin; Ilkka Kiviranta; Anna-Marja Säämänen; Markku Tammi; Heikki J Helminen
Indentation stiffness of young canine knee articular cartilage--influence of strenuous joint loading.
Journal of biomechanics 1990;23(12):1239-46.
1990: Raija Tammi; Markku Tammi; Lari Häkkinen; Hannu Larjava
Histochemical localization of hyaluronate in human oral epithelium using a specific hyaluronate-binding probe.
Archives of oral biology 1990;35(3):219-24.
1989: Anna-Marja Säämänen; Markku Tammi; Ilkka Kiviranta; Jukka S Jurvelin; Heikki J Helminen
Levels of chondroitin-6-sulfate and nonaggregating proteoglycans at articular cartilage contact sites in the knees of young dogs subjected to moderate running exercise.
Arthritis and rheumatism 1989;32(10):1282-92.
1989: Raija Tammi; J A Ripellino; Richard U Margolis; H I Maibach; Markku Tammi
Hyaluronate accumulation in human epidermis treated with retinoic acid in skin organ culture.
The Journal of investigative dermatology 1989;92(3):326-32.
1989: Jukka S Jurvelin; Ilkka Kiviranta; Anna-Marja Säämänen; Markku Tammi; Heikki J Helminen
Partial restoration of immobilization-induced softening of canine articular cartilage after remobilization of the knee (stifle) joint.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1989;7(3):352-8.
1989: Jyrki Parkkinen; Mikko Juhani Lammi; S Karjalainen; J Laakkonen; E Hyvärinen; A Tiihonen; Heikki J Helminen; Markku Tammi
A mechanical apparatus with microprocessor controlled stress profile for cyclic compression of cultured articular cartilage explants.
Journal of biomechanics 1989;22(11-12):1285-91.
1988: Hannu Larjava; Jyrki Heino; T Krusius; Eero Vuorio; Markku Tammi
The small dermatan sulphate proteoglycans synthesized by fibroblasts derived from skin, synovium and gingiva show tissue-related heterogeneity.
The Biochemical journal 1988;256(1):35-40.
1988: J Jurvelin; Anna-Marja Säämänen; Jari P A Arokoski; H J Helminen; I Kiviranta; Markku Tammi
Biomechanical properties of the canine knee articular cartilage as related to matrix proteoglycans and collagen.
Engineering in medicine 1988;17(4):157-62.
1988: Anna-Marja Säämänen; Markku Tammi; Ilkka Kiviranta; Heikki J Helminen
Running exercise as a modulatory of proteoglycan matrix in the articular cartilage of young rabbits.
International journal of sports medicine 1988;9(2):127-33.
1988: Jukka S Jurvelin; Tapani Lahtinen; Ilkka Kiviranta; I Arnala; R Lappalainen; Markku Tammi; Heikki J Helminen
Blood flow, histomorphology and elemental composition of the canine femur after physical training or immobilization.
Acta physiologica Scandinavica 1988;132(3):385-9.
1988: Raija Tammi; J A Ripellino; Richard U Margolis; Markku Tammi
Localization of epidermal hyaluronic acid using the hyaluronate binding region of cartilage proteoglycan as a specific probe.
The Journal of investigative dermatology 1988;90(3):412-4.
1988: Mikko Juhani Lammi; Markku Tammi
Densitometric assay of nanogram quantities of proteoglycans precipitated on nitrocellulose membrane with Safranin O.
Analytical biochemistry 1988;168(2):352-7.
1988: Ilkka Kiviranta; Markku Tammi; Jukka S Jurvelin; Anna-Marja Säämänen; Heikki J Helminen
Moderate running exercise augments glycosaminoglycans and thickness of articular cartilage in the knee joint of young beagle dogs.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 1988;6(2):188-95.
1988: Markku Tammi; Ilkka Kiviranta; L Peltonen; Jukka S Jurvelin; Heikki J Helminen
Effects of joint loading on articular cartilage collagen metabolism: assay of procollagen prolyl 4-hydroxylase and galactosylhydroxylysyl glucosyltransferase.
Connective tissue research 1988;17(3):199-206.
1987: Ilkka Kiviranta; Jukka S Jurvelin; Markku Tammi; Anna-Marja Säämänen; Heikki J Helminen
Weight bearing controls glycosaminoglycan concentration and articular cartilage thickness in the knee joints of young beagle dogs.
Arthritis and rheumatism 1987;30(7):801-9.
1987: Kirsti Näntö-Salonen; Hannu Larjava; A M Säämanen; Jyrki Heino; R Penttinen; L J Pelliniemi; Markku Tammi
Abnormal dermal proteoglycan in aspartylglycosaminuria: a possible mechanism for ultrastructural changes of collagen fibrils in a glycoprotein storage disorder.
Connective tissue research 1987;16(4):367-76.
1987: Anna-Marja Säämänen; Markku Tammi; Ilkka Kiviranta; Jukka S Jurvelin; Heikki J Helminen
Maturation of proteoglycan matrix in articular cartilage under increased and decreased joint loading. A study in young rabbits.
Connective tissue research 1987;16(2):163-75.
1987: Raija Tammi; A M Hyyryläinen; H I Maibach; Markku Tammi
Ultrastructural localization of keratinocyte surface associated heparan sulphate proteoglycans in human epidermis.
Histochemistry 1987;87(3):243-50.
1985: Jukka S Jurvelin; Heikki J Helminen; S Lauritsalo; Ilkka Kiviranta; Anna-Marja Säämänen; K Paukkonen; Markku Tammi
Influences of joint immobilization and running exercise on articular cartilage surfaces of young rabbits. A semiquantitative stereomicroscopic and scanning electron microscopic study.
Acta anatomica 1985;122(1):62-8.
1985: Ilkka Kiviranta; Markku Tammi; Jukka S Jurvelin; Anna-Marja Säämänen; Heikki J Helminen
Demonstration of chondroitin sulphate and glycoproteins in articular cartilage matrix using periodic acid-Schiff (PAS) method.
Histochemistry 1985;83(4):303-6.
1985: Ilkka Kiviranta; Jukka S Jurvelin; Markku Tammi; Anna-Marja Säämänen; Heikki J Helminen
Microspectrophotometric quantitation of glycosaminoglycans in articular cartilage sections stained with Safranin O.
Histochemistry 1985;82(3):249-55.
1984: Ilkka Kiviranta; Markku Tammi; Jukka S Jurvelin; Anna-Marja Säämänen; Heikki J Helminen
Fixation, decalcification, and tissue processing effects on articular cartilage proteoglycans.
Histochemistry 1984;80(6):569-73.
1984: K Paukkonen; Heikki J Helminen; Markku Tammi; Jukka S Jurvelin; Ilkka Kiviranta; Anna-Marja Säämänen
Quantitative morphological and biochemical investigations on the effects of physical exercise and immobilization on the articular cartilage of young rabbits.
Acta biologica Hungarica 1984;35(2-4):293-304.
1983: Heikki J Helminen; Jukka S Jurvelin; T Kuusela; R Heikkilä; Ilkka Kiviranta; Markku Tammi
Effects of immobilization for 6 weeks on rabbit knee articular surfaces as assessed by the semiquantitative stereomicroscopic method.
Acta anatomica 1983;115(4):327-35.
1983: Heikki J Helminen; Jukka S Jurvelin; T Kuusela; R Heikkilä; Ilkka Kiviranta; Markku Tammi
Semiquantitative analysis of rabbit knee articular surfaces based on stereomicroscopic examination of the cartilage.
Acta anatomica 1983;115(4):319-26.
1983: Jukka S Jurvelin; T Kuusela; R Heikkilä; Alpo Pelttari; Ilkka Kiviranta; Markku Tammi; Heikki J Helminen
Investigation of articular cartilage surface morphology with a semiquantitative scanning electron microscopic method.
Acta anatomica 1983;116(4):302-11.
1983: Markku Tammi; Anna-Marja Säämänen; A Jauhiainen; O Malminen; Ilkka Kiviranta; Heikki J Helminen
Proteoglycan alterations in rabbit knee articular cartilage following physical exercise and immobilization.
Connective tissue research 1983;11(1):45-55.
1980: Ilkka Kiviranta; Markku Tammi; R Lappalainen; T Kuusela; Heikki J Helminen
The rate of calcium extraction during EDTA decalcification from thin bone slices as assessed with atomic absorption spectrophotometry.
Histochemistry 1980;68(2):119-27.