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Aik Choon Tan

Research Profile

Procedures

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Anatomy

Tumor Cell Line

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Oligonucleotide Array Sequence Analysis

Chemicals & Drugs

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Publications

TOP 3
Djuana M E Harvell; Virginia F Borges; Britta M Jacobsen; Jihye Kim; Jenean O'Brien; Pepper Schedin; Aik Choon Tan; Kathryn B Horwitz
Genomic Signatures of Pregnancy-Associated Breast Cancer Epithelia and Stroma and their Regulation by Estrogens and Progesterone.
Jennifer Schlegel; Janiel M Shields; Aik Choon Tan; John J Tentler; Dimitri G Trembath; Xiaodong Wang; Amanda Winges; Chao Yang; Weihe Zhang; Ronald L Hamilton; Pei-Fen Kuan; Jing Liu; Bentley R Midkiff; C Ryan Miller; Stergios J Moschos; Nana Nikolaishvili-Feinberg; Maria J Sambade; Susan Sather; Craig C Carson; Deborah DeRyckere; Lyn M Duncan; H Shelton Earp; S Gail Eckhardt; Stephen V Frye; Douglas K Graham
MERTK receptor tyrosine kinase is a therapeutic target in melanoma.
Katherine R Singleton; Aik Choon Tan; Trista K Hinz; Jihye Kim; Lindsay Marek; Matias Casás-Selves; James DeGregori; Clark Hatheway; Lynn E Heasley
A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines.

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All Publications

2013: Djuana M E Harvell; Virginia F Borges; Britta M Jacobsen; Jihye Kim; Jenean O'Brien; Pepper Schedin; Aik Choon Tan; Kathryn B Horwitz
Genomic Signatures of Pregnancy-Associated Breast Cancer Epithelia and Stroma and their Regulation by Estrogens and Progesterone.
Hormones & cancer 2013;4(3):140-53.
2013: Jennifer Schlegel; Janiel M Shields; Aik Choon Tan; John J Tentler; Dimitri G Trembath; Xiaodong Wang; Amanda Winges; Chao Yang; Weihe Zhang; Ronald L Hamilton; Pei-Fen Kuan; Jing Liu; Bentley R Midkiff; C Ryan Miller; Stergios J Moschos; Nana Nikolaishvili-Feinberg; Maria J Sambade; Susan Sather; Craig C Carson; Deborah DeRyckere; Lyn M Duncan; H Shelton Earp; S Gail Eckhardt; Stephen V Frye; Douglas K Graham
MERTK receptor tyrosine kinase is a therapeutic target in melanoma.
The Journal of clinical investigation 2013;123(5):2257-67.
2013: Katherine R Singleton; Aik Choon Tan; Trista K Hinz; Jihye Kim; Lindsay Marek; Matias Casás-Selves; James DeGregori; Clark Hatheway; Lynn E Heasley
A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, and hepatocyte growth factor receptor drives growth and survival of head and neck squamous carcinoma cell lines.
Molecular pharmacology 2013;83(4):882-93.
2013: K E Ware; D Astling; C T Cummings; Douglas K. Graham; Barbara Helfrich; T K Hinz; E Kleczko; Lindsay Marek; K R Singleton; Aik Choon Tan; Lynn E Heasley
A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop.
Oncogenesis 2013;2():e39.
2013: Todd M Pitts; Heather M Selby; Anna Spreafico; Aik Choon Tan; John J Tentler; Marileila Varella-Garcia; John Arcaroli; Erica L Bradshaw-Pierce; Blair C Britt; Maria I Kachaeva; Gillian N Kulikowski; Kelly L McPhillips; Wells A Messersmith; Brion W Murray; S Gail Eckhardt
Association of the epithelial-to-mesenchymal transition phenotype with responsiveness to the p21-activated kinase inhibitor, PF-3758309, in colon cancer models.
Frontiers in pharmacology 2013;4():35.
2013: Erica L Bradshaw-Pierce; Daniel L Gustafson; Charles Halsey; Julie L C Kan; Nathan V Lee; Kelly McPhillips; Brion William Murray; Leslie Nguyen; Todd M Pitts; Aik Choon Tan; Mark West; S Gail Eckhardt
Tumor P-Glycoprotein Correlates with Efficacy of PF-3758309 in in vitro and in vivo Models of Colorectal Cancer.
Frontiers in pharmacology 2013;4():22.
2013: Jennifer R Diamond; S Gail Eckhardt; Graham C Fletcher; Maria I Kachaeva; Timothy P Newton; Todd M Pitts; Heather M Selby; Aik Choon Tan; Mark R Bray; Kelsey L Brunkow; Marileila Varella-Garcia; John J Tentler
Predictive biomarkers of sensitivity to the aurora and angiogenic kinase inhibitor ENMD-2076 in preclinical breast cancer models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2013;19(1):291-303.
2012: Erin D Giles; Sonali Jindal; Steven M Anderson; David P Astling; Pepper S Schedin; Aik Choon Tan; Ann D Thor; Elizabeth A Wellberg; Paul S MacLean
Obesity and overfeeding affecting both tumor and systemic metabolism activates the progesterone receptor to contribute to postmenopausal breast cancer.
Cancer research 2012;72(24):6490-501.
2012: John Arcaroli; Arvind Dasari; Charles Erlichman; Nathan R Foster; Manuel Hidalgo; Martine McManus; Sujatha Nallapareddy; Joel Picus; Rebecca Powell; Kevin Quackenbush; Aik Choon Tan; John Wright; Wells A Messersmith
Biomarker-driven trial in metastatic pancreas cancer: feasibility in a multicenter study of saracatinib, an oral Src inhibitor, in previously treated pancreatic cancer.
Cancer medicine 2012;1(2):207-17.
2012: Matias Casás-Selves; Daniel C Chan; Paul A Bunn; Dexiang Gao; Barbara Helfrich; Jihye Kim; Christopher C Porter; Hannah A Scarborough; Aik Choon Tan; Zhiyong Zhang; James DeGregori
Tankyrase and the canonical Wnt pathway protect lung cancer cells from EGFR inhibition.
Cancer research 2012;72(16):4154-64.
2012: Kelly D Sullivan; Aik Choon Tan; John J Tentler; James DeGregori; S Gail Eckhardt; Ryan E Henry; Jihye Kim; Nuria Padilla-Just; Christopher C Porter; Joaquín Maximiliano Espinosa
ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.
Nature chemical biology 2012;8(7):646-54.
2012: John Arcaroli; Arvind Dasari; Dexiang Gao; Martine McManus; Todd M Pitts; Rebecca W Powell; Kevin S Quackenbush; Anna Spreafico; Aik Choon Tan; Basel M Touban; Marileila Varella-Garcia; Wells A Messersmith
ALDH+ tumor-initiating cells exhibiting gain in NOTCH1 gene copy number have enhanced regrowth sensitivity to a γ-secretase inhibitor and irinotecan in colorectal cancer.
Molecular oncology 2012;6(3):370-81.
2012: John J Tentler; Colin D Weekes; John Arcaroli; Antonio Jimeno; Stephen Leong; Wells A Messersmith; Todd M Pitts; Aik Choon Tan; S Gail Eckhardt
Patient-derived tumour xenografts as models for oncology drug development.
Nature reviews. Clinical oncology 2012;9(6):338-50.
2012: John Arcaroli; Lynne Bemis; Arvind Dasari; S Gail Eckhardt; Todd M Pitts; Rebecca W Powell; Kevin S Quackenbush; Jaclyn M Reinemann; Anna Spreafico; Aik Choon Tan; Basel M Touban; Marileila Varella-Garcia; Wells A Messersmith
Common PIK3CA mutants and a novel 3' UTR mutation are associated with increased sensitivity to saracatinib.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(9):2704-14.
2012: James M Haughian; Päivi Heikkilä; Brian S Bliesner; Wendy W Dye; Joshua Chuck Harrell; Kristiina M Joensuu; Charles M Perou; Mauricio P Pinto; Carol A Sartorius; Aik Choon Tan; Kathryn B Horwitz
Maintenance of hormone responsiveness in luminal breast cancers by suppression of Notch.
Proceedings of the National Academy of Sciences of the United States of America 2012;109(8):2742-7.
2012: M Pia Morelli; Sujatha Nallapareddy; Todd M Pitts; Natalie J Serkova; Aik Choon Tan; John J Tentler; John J Arcaroli; Erica L Bradshaw-Pierce; Amy M Brown; Fortunato Ciardiello; Manuel Hidalgo; Gillian N Kulikowski; S Gail Eckhardt
Preclinical activity of the rational combination of selumetinib (AZD6244) in combination with vorinostat in KRAS-mutant colorectal cancer models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2012;18(4):1051-62.
2012: Xinjian Liu; Toni L Richards; John R Sladek; Elizabeth A Stubblefield; Aik Choon Tan; Nancy R Zahniser; Dabing Zhang; Timothy A Benke; Barbara Blanchard; Yujun He; Qian Huang; Gaynor A Larson; Fang Li; Chuan-Yuan Li
Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells.
Cell research 2012;22(2):321-32.
2012: Jihye Kim; Aik Choon Tan
BiNGS!SL-seq: a bioinformatics pipeline for the analysis and interpretation of deep sequencing genome-wide synthetic lethal screen.
Methods in molecular biology (Clifton, N.J.) 2012;802():389-98.
2012: Aik Choon Tan
Employing gene set top scoring pairs to identify deregulated pathway-signatures in dilated cardiomyopathy from integrated microarray gene expression data.
Methods in molecular biology (Clifton, N.J.) 2012;802():345-61.
2011: Traci R. Lyons; Andriy Marusyk; Jenean O'Brien; Virginia Borges; Matthew W Conklin; Kevin W Eliceiri; Patricia J Keely; Aik Choon Tan; Pepper Schedin
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2.
Nature medicine 2011;17(9):1109-15.
2011: Ignacio Garrido-Laguna; Elizabeth de Oliveira; Ralph Hruban; Antonio Jimeno; Collins A Karikari; Daniel Laheru; Anirban Maitra; RAJESH KUMAR NV; Belen Rubio-Viqueira; Ana Salomon; Rajni Sharma; Aik Choon Tan; Gretchen Taylor; Maria Uson; Maria C Villaroel; Manuel Hidalgo
Tumor engraftment in nude mice and enrichment in stroma- related gene pathways predict poor survival and resistance to gemcitabine in patients with pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2011;17(17):5793-800.
2011: Qian Huang; Antonio Jimeno; Joel S Bedford; Gangwen Han; Zhimin He; Fang Li; Wenrong Li; Fei-Fei Liu; Xinjian Liu; Brian O'Sullivan; Yuanlin Peng; David Raben; Jingping Shen; Wei Shi; Aik Choon Tan; Andrew Thorburn; Jackie Thorburn; Xiao-Jing Wang; Ling Zhou; Chuan-Yuan Li
Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy.
Nature medicine 2011;17(7):860-6.
2011: Sok Kean Khoo; Mrutyunjaya Parida; David Petillo; James Resau; Aik Choon Tan; Stephen Obaro
Host response transcriptional profiling reveals extracellular components and ABC (ATP-binding cassette) transporters gene enrichment in typhoid fever-infected Nigerian children.
BMC infectious diseases 2011;11():241.
2011: Hyunmin Kim; Jihye Kim; Heather Selby; Dexiang Gao; Tiejun Tong; Tzu Lip Phang; Aik Choon Tan
A short survey of computational analysis methods in analysing ChIP-seq data.
Human genomics 2011;5(2):117-23.
2011: Lee K Jones; Fei Zou; Alexander Kheifets; Konstantin Rybnikov; Damon Berry; Aik Choon Tan
Confident predictability: identifying reliable gene expression patterns for individualized tumor classification using a local minimax kernel algorithm.
BMC medical genomics 2011;4():10.
2010: John J Tentler; Sujatha Nallapareddy; Aik Choon Tan; Anna Spreafico; Todd M Pitts; M Pia Morelli; Heather M Selby; Maria I Kachaeva; Sara A Flanigan; Gillian N Kulikowski; Stephen Leong; John J Arcaroli; Wells A Messersmith; S Gail Eckhardt
Identification of predictive markers of response to the MEK1/2 inhibitor selumetinib (AZD6244) in K-ras-mutated colorectal cancer.
Molecular cancer therapeutics 2010;9(12):3351-62.
2010: D Ross Camidge; Scott A Kono; Antonella Flacco; Aik Choon Tan; Robert C Doebele; Qing Zhou; Lucio Crino; Wilbur A Franklin; Marileila Varella-Garcia
Optimizing the detection of lung cancer patients harboring anaplastic lymphoma kinase (ALK) gene rearrangements potentially suitable for ALK inhibitor treatment.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(22):5581-90.
2010: Sara A Flanigan; Todd M Pitts; S Gail Eckhardt; John J Tentler; Aik Choon Tan; Andrew Thorburn; Stephen Leong
The insulin-like growth factor I receptor/insulin receptor tyrosine kinase inhibitor PQIP exhibits enhanced antitumor effects in combination with chemotherapy against colorectal cancer models.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(22):5436-46.
2010: Dexiang Gao; Jihye Kim; Hyunmin Kim; Tzu L Phang; Heather Selby; Aik Choon Tan; Tiejun Tong
A survey of statistical software for analysing RNA-seq data.
Human genomics 2010;5(1):56-60.
2010: I Garrido-Laguna; Aik Choon Tan; M Uson; M Angenendt; Wen W Ma; M C Villaroel; Ming Zhao; RAJESH KUMAR NV; Antonio Jimeno; Ross C Donehower; Christine A Iacobuzio-Donahue; M Barrett; MICHELLE RUDEK-RENAUT; Belen Rubio-Viqueira; Daniel Laheru; Manuel Hidalgo
Integrated preclinical and clinical development of mTOR inhibitors in pancreatic cancer.
British journal of cancer 2010;103(5):649-55.
2010: John J Arcaroli; Basel M Touban; Aik Choon Tan; Marileila Varella-Garcia; Rebecca W Powell; S Gail Eckhardt; Paul Elvin; Dexiang Gao; Wells A Messersmith
Gene array and fluorescence in situ hybridization biomarkers of activity of saracatinib (AZD0530), a Src inhibitor, in a preclinical model of colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(16):4165-77.
2010: Todd M Pitts; Aik Choon Tan; Gillian N Kulikowski; John J Tentler; Amy M Brown; Sara A Flanigan; Stephen Leong; Christopher D Coldren; Fred R Hirsch; Marileila Varella-Garcia; Christopher Korch; S Gail Eckhardt
Development of an integrated genomic classifier for a novel agent in colorectal cancer: approach to individualized therapy in early development.
Clinical cancer research : an official journal of the American Association for Cancer Research 2010;16(12):3193-204.
2010: Stephen Leong; Wells A Messersmith; Aik Choon Tan; S Gail Eckhardt
Novel agents in the treatment of metastatic colorectal cancer.
Cancer journal (Sudbury, Mass.) 2010;16(3):273-82.
2009: Aik Choon Tan; Antonio Jimeno; Steven H Lin; Jenna Wheelhouse; Fonda Chan; Anna Solomon; RAJESH KUMAR NV; Belen Rubio-Viqueira; Manuel Hidalgo
Characterizing DNA methylation patterns in pancreatic cancer genome.
Molecular oncology 2009;3(5-6):425-38.
2009: Yuan Tian; Zhi Xie; Zhen Zhang; Daniel W Chan; Natini Jinawath; Matthew T Olson; Ie-Ming Shih; Xiaer Sun; Aik Choon Tan; HUI ZHANG
Quantitative proteomic analysis of ovarian cancer cells identified mitochondrial proteins associated with Paclitaxel resistance.
Proteomics. Clinical applications 2009;3(11):1288-95.
2009: Oliver A Kent; Michael Mullendore; Erik A Wentzel; Pedro López-Romero; Aik Choon Tan; Hector Alvarez; Kristen West; Michael Ochs; Manuel Hidalgo; Dan E Arking; Anirban Maitra; Joshua T Mendell
A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells.
Cancer biology & therapy 2009;8(21):2013-24.
2009: Chien-Sheng Chen; Sean Sullivan; Troy Anderson; Aik Choon Tan; Philip J Alex; Steven R Brant; C Cuffari; Theodore M Bayless; Monica V Talor; CAROL BUREK; Huan Wang; Richard Li; Lisa Datta; Yuqiong Wu; Raimond L Winslow; Heng Zhu; Xuhang Li
Identification of novel serological biomarkers for inflammatory bowel disease using Escherichia coli proteome chip.
Molecular & cellular proteomics : MCP 2009;8(8):1765-76.
2009: RAJESH KUMAR NV; Aik Choon Tan; Elizabeth De Oliveira; Chris Womack; Helen Wombwell; Shethah Morgan; Madhuri V Warren; Jill Walker; Tim P Green; Antonio Jimeno; Wells A Messersmith; Manuel Hidalgo
Antitumor effects and biomarkers of activity of AZD0530, a Src inhibitor, in pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2009;15(12):4138-46.
2009: Wells A Messersmith; RAJESH KUMAR NV; Aik Choon Tan; Xiao Fei Wang; Veronica Diesl; Sung E Choe; Max Follettie; Christina Coughlin; Frank Boschelli; Elena Garcia-Garcia; Fernando Lopez-Rios; Antonio Jimeno; Manuel Hidalgo
Efficacy and pharmacodynamic effects of bosutinib (SKI-606), a Src/Abl inhibitor, in freshly generated human pancreas cancer xenografts.
Molecular cancer therapeutics 2009;8(6):1484-93.
2008: Dongweon Song; Raghothama Chaerkady; Aik Choon Tan; Elena García-García; Anuradha Nalli; Ana Suárez-Gauthier; Fernando López-Ríos; Xian Feng Zhang; Anna Solomon; Jeffrey Tong; Margaret Read; Christian Fritz; Antonio Jimeno; Akhilesh Pandey; Manuel Hidalgo
Antitumor activity and molecular effects of the novel heat shock protein 90 inhibitor, IPI-504, in pancreatic cancer.
Molecular cancer therapeutics 2008;7(10):3275-84.
2008: Antonio Jimeno; Aik Choon Tan; Jordy Coffa; RAJESH KUMAR NV; Piotr Kulesza; Belen Rubio-Viqueira; Jenna Wheelhouse; Begoña Diosdado; Wells A Messersmith; Christine A Iacobuzio-Donahue; Anirban Maitra; Marileila Varella-Garcia; Fred R Hirsch; Gerrit A Meijer; Manuel Hidalgo
Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer.
Cancer research 2008;68(8):2841-9.
2008: Lei Xu; Aik Choon Tan; Raimond L Winslow; Donald Geman
Merging microarray data from separate breast cancer studies provides a robust prognostic test.
BMC bioinformatics 2008;9():125.
2008: Aik Choon Tan; Jian-Bing Fan; Collins Karikari; Marina Bibikova; Eliza Wickham Garcia; Lixin Zhou; David Barker; david serre; Georg Feldmann; Ralph Hruban; Alison P Klein; Michael Goggins; Fergus J. Couch; Thomas J Hudson; Raimond L Winslow; Anirban Maitra; Aravinda Chakravarti
Allele-specific expression in the germline of patients with familial pancreatic cancer: an unbiased approach to cancer gene discovery.
Cancer biology & therapy 2008;7(1):135-44.
2005: Lei Xu; Aik Choon Tan; Daniel Q Naiman; Donald Geman; Raimond L Winslow
Robust prostate cancer marker genes emerge from direct integration of inter-study microarray data.
Bioinformatics (Oxford, England) 2005;21(20):3905-11.
2005: Aik Choon Tan; Daniel Q Naiman; Lei Xu; Raimond L Winslow; Donald Geman
Simple decision rules for classifying human cancers from gene expression profiles.
Bioinformatics (Oxford, England) 2005;21(20):3896-904.
2004: Te Ren; Mallika Veeramalai; Aik Choon Tan; David Gilbert
MSAT: a multiple sequence alignment tool based on TOPS.
Applied bioinformatics 2004;3(2-3):149-58.
2003: Aik Choon Tan; David Gilbert; Yves Deville
Multi-class protein fold classification using a new ensemble machine learning approach.
Genome informatics. International Conference on Genome Informatics 2003;14():206-17.
2003: Aik Choon Tan; David Gilbert
Ensemble machine learning on gene expression data for cancer classification.
Applied bioinformatics 2003;2(3 Suppl):S75-83.

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