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Tse-Hua Tan

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Xiaohong Wang; Jonathan Boomer; Der-Yuan Chen; Li-Li Chiu; Joung-Liang Lan; Ju-Pi Li; Tse-Hua Tan
Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein.
Kuan-Ru Chen; Lin-Fang Chen; En-Wei Hsing; Ching-Yu Huang; Huan-Yao Lei; Chun-Yang Lin; Wan-Ying Lin; Yin-Chiu Lo; Ai-Li Shiau; Shin-Ru Shih; Tse-Hua Tan; Chia-Yu Yang; Chun-Hung Chang; Pin Ling
TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity.
Xiaohong Wang; Chia-Yu Yang; Der-Yuan Chen; Li-Li Chiu; Gregory A Dement; Hongbo Hu; Hui-Kai Kuo; Joung-Liang Lan; Ju-Pi Li; Tse-Hua Tan
Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK).

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2012: Xiaohong Wang; Jonathan Boomer; Der-Yuan Chen; Li-Li Chiu; Joung-Liang Lan; Ju-Pi Li; Tse-Hua Tan
Attenuation of T cell receptor signaling by serine phosphorylation-mediated lysine 30 ubiquitination of SLP-76 protein.
The Journal of biological chemistry 2012;287(41):34091-100.
2012: Kuan-Ru Chen; Lin-Fang Chen; En-Wei Hsing; Ching-Yu Huang; Huan-Yao Lei; Chun-Yang Lin; Wan-Ying Lin; Yin-Chiu Lo; Ai-Li Shiau; Shin-Ru Shih; Tse-Hua Tan; Chia-Yu Yang; Chun-Hung Chang; Pin Ling
TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity.
The Journal of biological chemistry 2012;287(38):32216-21.
2012: Xiaohong Wang; Chia-Yu Yang; Der-Yuan Chen; Li-Li Chiu; Gregory A Dement; Hongbo Hu; Hui-Kai Kuo; Joung-Liang Lan; Ju-Pi Li; Tse-Hua Tan
Down-regulation of B cell receptor signaling by hematopoietic progenitor kinase 1 (HPK1)-mediated phosphorylation and ubiquitination of activated B cell linker protein (BLNK).
The Journal of biological chemistry 2012;287(14):11037-48.
2012: Ching-Yu Huang; Pau-Yi Huang; Fang-Hsuean Liao; Yu-Chun Lin; Wan-Yi Hsiao; Tse-Hua Tan
DUSP4 deficiency enhances CD25 expression and CD4+ T-cell proliferation without impeding T-cell development.
European journal of immunology 2012;42(2):476-88.
2012: Der-Yuan Chen; Yi-Ming Chen; Huai-Chia Chuang; Wei-Ting Hung; Kuo-Lung Lai; Joung-Liang Lan; Tse-Hua Tan
Germinal center kinase-like kinase (GLK/MAP4K3) expression is increased in adult-onset Still's disease and may act as an activity marker.
BMC medicine 2012;10():84.
2012: Xiaohong Wang; Huai-Chia Chuang; Ju-Pi Li; Tse-Hua Tan
Regulation of PKC-θ function by phosphorylation in T cell receptor signaling.
Frontiers in immunology 2012;3():197.
2012: Ching-Yu Huang; Tse-Hua Tan
DUSPs, to MAP kinases and beyond.
Cell & bioscience 2012;2(1):24.
2011: Huai-Chia Chuang; Ching-Yu Huang; Joung-Liang Lan; Ju-Pi Li; Pao-En Liu; Der-Yuan Chen; Yi-Ming Chen; Xiaohong Wang; Chia-Yu Yang; Tse-Hua Tan
The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells.
Nature immunology 2011;12(11):1113-8.
2010: Ju-Pi Li; Yu-Ning Fu; Yi-Rong Chen; Tse-Hua Tan
JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration.
The Journal of biological chemistry 2010;285(8):5472-8.
2009: Katherine L Tucker; William J Kaiser; Angela L Bergeron; Hongbo Hu; Jing-fei Dong; Tse-Hua Tan; Jonathan M Gibbins
Proteomic analysis of resting and thrombin-stimulated platelets reveals the translocation and functional relevance of HIP-55 in platelets.
Proteomics 2009;9(18):4340-54.
2009: Huamin Wang; Xianzhou Song; Craig Logsdon; Guisheng Zhou; Douglas B Evans; James L Abbruzzese; Stanley R Hamilton; Tse-Hua Tan; Huamin Wang
Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer.
Cancer research 2009;69(3):1063-70.
2008: John J Liang; Hua Wang; Asif Rashid; Tse-Hua Tan; Rosa F Hwang; Stanley R Hamilton; James L Abbruzzese; Douglas B Evans; Huamin Wang
Expression of MAP4K4 is associated with worse prognosis in patients with stage II pancreatic ductal adenocarcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008;14(21):7043-9.
2008: Olusegun Onabajo; Margaret K Seeley; Amruta Kale; Britta Qualmann; Michael kessels; Jin Han; Tse-Hua Tan; Wenxia Song
Actin-binding protein 1 regulates B cell receptor-mediated antigen processing and presentation in response to B cell receptor activation.
Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6685-95.
2007: Min Chen; Alan D Guerrero; Li Huang; Zainuer Shabier; Michael Pan; Tse-Hua Tan; Jin Wang
Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members.
The Journal of biological chemistry 2007;282(46):33888-95.
2007: Jr-Wen Shui; Jonathan S Boomer; Jin Han; Jun Xu; Gregory A Dement; Guisheng Zhou; Tse-Hua Tan
Hematopoietic progenitor kinase 1 negatively regulates T cell receptor signaling and T cell-mediated immune responses.
Nature immunology 2007;8(1):84-91.
2007: Jr-Wen Shui; Mickey C-T Hu; Tse-Hua Tan
Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling.
Molecular and cellular biology 2007;27(1):79-91.
2006: Jiz-Yuh Wang; Chia-Hua Lin; Chi-Hwa Yang; Tse-Hua Tan; Yi-Rong Chen
Biochemical and biological characterization of a neuroendocrine-associated phosphatase.
Journal of neurochemistry 2006;98(1):89-101.
2006: Hsin-Sheng Yang; Connie P Matthews; Timothy Clair; Qing Wang; Alyson R Baker; Chou-Chi H Li; Tse-Hua Tan; Nancy H Colburn
Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion.
Molecular and cellular biology 2006;26(4):1297-306.
2005: Jin Han; Jr-Wen Shui; Xuejun Zhang; B Zheng; Shuhua Han; Tse-Hua Tan
HIP-55 is important for T-cell proliferation, cytokine production, and immune responses.
Molecular and cellular biology 2005;25(16):6869-78.
2005: Jonathan S Boomer; Tse-Hua Tan
Functional interactions of HPK1 with adaptor proteins.
Journal of cellular biochemistry 2005;95(1):34-44.
2005: Xiaohong Zhang; Yukiyasu Ozawa; Heehyoung Lee; Yu-Der Wen; Tse-Hua Tan; Brian E Wadzinski; Edward Seto
Histone deacetylase 3 (HDAC3) activity is regulated by interaction with protein serine/threonine phosphatase 4.
Genes & development 2005;19(7):827-39.
2005: Rebecca Hall; Tse-Hua Tan
Mitogen-activated protein kinases in cell-cycle control.
Cell biochemistry and biophysics 2005;43(3):451-61.
2004: Guisheng Zhou; Jonathan S Boomer; Tse-Hua Tan
Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1.
The Journal of biological chemistry 2004;279(47):49551-61.
2004: Kathie A Mihindukulasuriya; Guisheng Zhou; Jun Qin; Tse-Hua Tan
Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation.
The Journal of biological chemistry 2004;279(45):46588-94.
2004: Rebecca Hall; Tse-Hua Tan
Inhibition of JNK2 disrupts anaphase and produces aneuploidy in mammalian cells.
The Journal of biological chemistry 2004;279(38):40112-21.
2004: Jr-Wen Shui; Tse-Hua Tan
Germline transmission and efficient DNA recombination in mouse embryonic stem cells mediated by adenoviral-Cre transduction.
Genesis (New York, N.Y. : 2000) 2004;39(3):217-23.
2003: Jin Han; Rajashree Kori; Jr-Wen Shui; Yi-Rong Chen; Zhengbin Yao; Tse-Hua Tan
The SH3 domain-containing adaptor HIP-55 mediates c-Jun N-terminal kinase activation in T cell receptor signaling.
The Journal of biological chemistry 2003;278(52):52195-202.
2003: B Zheng; Ekaterina Marinova; Jin Han; Tse-Hua Tan; Shuhua Han
Cutting edge: gamma delta T cells provide help to B cells with altered clonotypes and are capable of inducing Ig gene hypermutation.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(10):4979-83.
2002: Yi-Rong Chen; Jin Han; Rajashree Kori; Ah-Ng Tony Kong; Tse-Hua Tan
Phenylethyl isothiocyanate induces apoptotic signaling via suppressing phosphatase activity against c-Jun N-terminal kinase.
The Journal of biological chemistry 2002;277(42):39334-42.
2002: Alice J Chen; Guisheng Zhou; Todd Juan; Suzanne M Colicos; John P Cannon; Maria Cabriera-Hansen; Christian F Meyer; Roland Jurecic; Neal G Copeland; Debra J Gilbert; Nancy A Jenkins; Fred Fletcher; Tse-Hua Tan; John W Belmont
The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway.
The Journal of biological chemistry 2002;277(39):36592-601.
2002: Guisheng Zhou; Kathie A Mihindukulasuriya; Rebecca Hall; Aaron A Van Hooser; Mickey C-T Hu; Bill R Brinkley; Tse-Hua Tan
Protein phosphatase 4 is involved in tumor necrosis factor-alpha-induced activation of c-Jun N-terminal kinase.
The Journal of biological chemistry 2002;277(8):6391-8.
2001: Rebecca Hall; A VanHooser; DW Goodrich; Bill R Brinkley; Tse-Hua Tan
Cell cycle regulation of c-Jun N-terminal kinase activity at the centrosomes.
Biochemical and biophysical research communications 2001;289(1):173-80.
2001: Yi-Rong Chen; Rajashree Kori; B John; Tse-Hua Tan
Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis.
Biochemical and biophysical research communications 2001;288(4):981-9.
2001: Mickey C-T Hu; Jr-Wen Shui; Kathie A Mihindukulasuriya; Tse-Hua Tan
Genomic structure of the mouse PP4 gene: a developmentally regulated protein phosphatase.
Gene 2001;278(1-2):89-99.
2001: P Ling; Christian F Meyer; L P Redmond; Jr-Wen Shui; B Davis; R R Rich; Mickey C-T Hu; R L Wange; Tse-Hua Tan
Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling.
The Journal of biological chemistry 2001;276(22):18908-14.
2001: Yi-Rong Chen; A Shrivastava; Tse-Hua Tan
Down-regulation of the c-Jun N-terminal kinase (JNK) phosphatase M3/6 and activation of JNK by hydrogen peroxide and pyrrolidine dithiocarbamate.
Oncogene 2001;20(3):367-74.
2000: R Yu; Chin Chen; Yin-Yuan Mo; Vidya Hebbar; Edward D Owuor; Tse-Hua Tan; Ah-Ng Tony Kong
Activation of mitogen-activated protein kinase pathways induces antioxidant response element-mediated gene expression via a Nrf2-dependent mechanism.
The Journal of biological chemistry 2000;275(51):39907-13.
2000: Sandhya Mandlekar; R Yu; Tse-Hua Tan; Ah-Ng Tony Kong
Activation of caspase-3 and c-Jun NH2-terminal kinase-1 signaling pathways in tamoxifen-induced apoptosis of human breast cancer cells.
Cancer research 2000;60(21):5995-6000.
2000: Y R Chen; Tse-Hua Tan
The c-Jun N-terminal kinase pathway and apoptotic signaling (review).
International journal of oncology 2000;16(4):651-62.
2000: R Yu; Sandhya Mandlekar; Tse-Hua Tan; Ah-Ng Tony Kong
Activation of p38 and c-Jun N-terminal kinase pathways and induction of apoptosis by chelerythrine do not require inhibition of protein kinase C.
The Journal of biological chemistry 2000;275(13):9612-9.
2000: R Yu; Sandhya Mandlekar; W Lei; W E Fahl; Tse-Hua Tan; Ah-Ng Tony Kong
p38 mitogen-activated protein kinase negatively regulates the induction of phase II drug-metabolizing enzymes that detoxify carcinogens.
The Journal of biological chemistry 2000;275(4):2322-7.
1999: Yi-Rong Chen; Christian F Meyer; B Ahmed; Z Yao; Tse-Hua Tan
Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1).
Oncogene 1999;18(51):7370-7.
1999: Yi-Rong Chen; G Zhou; Tse-Hua Tan
c-Jun N-terminal kinase mediates apoptotic signaling induced by N-(4-hydroxyphenyl)retinamide.
Molecular pharmacology 1999;56(6):1271-9.
1999: Diana Ensenat; Zhengbin Yao; X S Wang; Rajashree Kori; Guisheng Zhou; S C Lee; Tse-Hua Tan
A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1.
The Journal of biological chemistry 1999;274(48):33945-50.
1999: Mickey C-T Hu; WR Qiu; A Mikhail; Christian F Meyer; Y p Wang; Tse-Hua Tan
Hematopoietic progenitor kinase-1 (HPK1) stress response signaling pathway activates IkappaB kinases (IKK-alpha/beta) and IKK-beta is a developmentally regulated protein kinase.
Oncogene 1999;18(40):5514-24.
1999: Guisheng Zhou; S C Lee; Zhengbin Yao; Tse-Hua Tan
Hematopoietic progenitor kinase 1 is a component of transforming growth factor beta-induced c-Jun N-terminal kinase signaling cascade.
The Journal of biological chemistry 1999;274(19):13133-8.
1999: Yi-Rong Chen; Tse-Hua Tan
Lack of correlation in JNK activation and p53-dependent Fas expression induced by apoptotic stimuli.
Biochemical and biophysical research communications 1999;256(3):595-9.
1999: Mickey C-T Hu; YP Wang; A Mikhail; WR Qiu; Tse-Hua Tan
Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines.
The Journal of biological chemistry 1999;274(11):7095-102.
1999: P Ling; Z Yao; Christian F Meyer; X S Wang; W Oehrl; Stephan M Feller; Tse-Hua Tan
Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase.
Molecular and cellular biology 1999;19(2):1359-68.
1999: Z Yao; G Zhou; XS Wang; A Brown; K Diener; H Gan; Tse-Hua Tan
A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway.
The Journal of biological chemistry 1999;274(4):2118-25.
1999: Alexander A Shtil; Sandhya Mandlekar; R Yu; robert walter; K Hagen; Tse-Hua Tan; Igor B Roninson; Ah-Ng Tony Kong
Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells.
Oncogene 1999;18(2):377-84.
1998: Mickey C-T Hu; Q Tang-Oxley; WR Qiu; YP Wang; Kathie A Mihindukulasuriya; R Afshar; Tse-Hua Tan
Protein phosphatase X interacts with c-Rel and stimulates c-Rel/nuclear factor kappaB activity.
The Journal of biological chemistry 1998;273(50):33561-5.
1998: XS Wang; K Diener; Tse-Hua Tan; Z Yao
MAPKKK6, a novel mitogen-activated protein kinase kinase kinase, that associates with MAPKKK5.
Biochemical and biophysical research communications 1998;253(1):33-7.
1998: W Oehrl; Christian Kardinal; S Ruf; Knut Adermann; J Groffen; G S Feng; J Blenis; Tse-Hua Tan; Stephan M Feller
The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins.
Oncogene 1998;17(15):1893-901.
1998: Yi-Rong Chen; Tse-Hua Tan
Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin.
Oncogene 1998;17(2):173-8.
1998: Ah-Ng Tony Kong; R Yu; W Lei; Sandhya Mandlekar; Tse-Hua Tan; David S Ucker
Differential activation of MAPK and ICE/Ced-3 protease in chemical-induced apoptosis. The role of oxidative stress in the regulation of mitogen-activated protein kinases (MAPKs) leading to gene expression and survival or activation of caspases leading to apoptosis.
Restorative neurology and neuroscience 1998;12(2-3):63-70.
1998: Yi-Rong Chen; Wei Wang; Ah-Ng Tony Kong; Tse-Hua Tan
Molecular mechanisms of c-Jun N-terminal kinase-mediated apoptosis induced by anticarcinogenic isothiocyanates.
The Journal of biological chemistry 1998;273(3):1769-75.
1997: Z Yao; K Diener; XS Wang; M Zukowski; G Matsumoto; G Zhou; Rong Mo; T Sasaki; Hiroshi Nishina; Chi-Chung Hui; Tse-Hua Tan; J P Woodgett; J M Penninger
Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase.
The Journal of biological chemistry 1997;272(51):32378-83.
1997: R Yu; Tse-Hua Tan; Ah-Ng Tony Kong
Butylated hydroxyanisole and its metabolite tert-butylhydroquinone differentially regulate mitogen-activated protein kinases. The role of oxidative stress in the activation of mitogen-activated protein kinases by phenolic antioxidants.
The Journal of biological chemistry 1997;272(46):28962-70.
1997: Wei Wang; Guisheng Zhou; Mickey C-T Hu; Zhengbin Yao; Tse-Hua Tan
Activation of the hematopoietic progenitor kinase-1 (HPK1)-dependent, stress-activated c-Jun N-terminal kinase (JNK) pathway by transforming growth factor beta (TGF-beta)-activated kinase (TAK1), a kinase mediator of TGF beta signal transduction.
The Journal of biological chemistry 1997;272(36):22771-5.
1997: K Diener; XS Wang; C Chen; Christian F Meyer; GA Keesler; M Zukowski; Tse-Hua Tan; Z Yao
Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase.
Proceedings of the National Academy of Sciences of the United States of America 1997;94(18):9687-92.
1996: Yi-Rong Chen; X Wang; D Templeton; R J Davis; Tse-Hua Tan
The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation.
The Journal of biological chemistry 1996;271(50):31929-36.
1996: XS Wang; K Diener; D Jannuzzi; D Trollinger; Tse-Hua Tan; HS Lichenstein; M Zukowski; Z Yao
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase.
The Journal of biological chemistry 1996;271(49):31607-11.
1996: R Yu; Alexander A Shtil; Tse-Hua Tan; Igor B Roninson; Ah-Ng Tony Kong
Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis.
Cancer letters 1996;107(1):73-81.
1996: Mickey C-T Hu; WR Qiu; X Wang; Christian F Meyer; Tse-Hua Tan
Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade.
Genes & development 1996;10(18):2251-64.
1996: R Yu; J J Jiao; J L Duh; Tse-Hua Tan; Ah-Ng Tony Kong
Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1.
Cancer research 1996;56(13):2954-9.
1996: Christian F Meyer; X Wang; C Chang; D Templeton; Tse-Hua Tan
Interaction between c-Rel and the mitogen-activated protein kinase kinase kinase 1 signaling cascade in mediating kappaB enhancer activation.
The Journal of biological chemistry 1996;271(15):8971-6.
1996: Yi-Rong Chen; Christian F Meyer; Tse-Hua Tan
Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis.
The Journal of biological chemistry 1996;271(2):631-4.
1995: J H Lai; G Horvath; Y Li; Tse-Hua Tan
Mechanisms of enhanced nuclear translocation of the transcription factors c-Rel and NF-kappa B by CD28 costimulation in human T lymphocytes.
Annals of the New York Academy of Sciences 1995;766():220-3.
1995: J H Lai; G Horvath; J Subleski; J Bruder; P Ghosh; Tse-Hua Tan
RelA is a potent transcriptional activator of the CD28 response element within the interleukin 2 promoter.
Molecular and cellular biology 1995;15(8):4260-71.
1994: J H Lai; Tse-Hua Tan
CD28 signaling causes a sustained down-regulation of I kappa B alpha which can be prevented by the immunosuppressant rapamycin.
The Journal of biological chemistry 1994;269(48):30077-80.
1994: R G Bryan; Y Li; J H Lai; M Van; N R Rice; Robert R Rich; Tse-Hua Tan
Effect of CD28 signal transduction on c-Rel in human peripheral blood T cells.
Molecular and cellular biology 1994;14(12):7933-42.
1994: R G Bryan; Y Li; R K Totten; M Van; Tse-Hua Tan; Robert R Rich
Long-term inositol phosphate release, but not tyrosine kinase activity, correlates with IL-2 secretion and NF-AT induction in anti-CD3-activated peripheral human T lymphocytes.
Cellular immunology 1994;157(1):158-69.