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Akiko Tanaka

Research Profile

Chemicals & Drugs

Living Beings

Physiology

Gastrointestinal Motility

Anatomy

Disorders

Stomach Ulcer

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Publications

TOP 3
Koji Takeuchi; Akiko Tanaka; Melinda Gyenge; Azusa Kojo; Kazuo Nukui; Kikuko Amagase
Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.
Akiko Tanaka; Sadaki Fujimoto; Youichirou Higashi; Kentaro Nishida; Takeshi Nishiura; Hiroto Okuda; Kazuki Nagasawa
Peroxynitrite treatment reduces adenosine uptake via the equilibrative nucleoside transporter in rat astrocytes.
Koji Takeuchi; Akiko Tanaka; Shinichi Kato; Kikuko Amagase; Hiroshi Satoh
Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.

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All Publications

2011: Koji Takeuchi; Akiko Tanaka; Melinda Gyenge; Azusa Kojo; Kazuo Nukui; Kikuko Amagase
Aggravation by paroxetine, a selective serotonin reuptake inhibitor, of antral lesions generated by nonsteroidal anti-inflammatory drugs in rats.
The Journal of pharmacology and experimental therapeutics 2011;338(3):850-9.
2011: Akiko Tanaka; Sadaki Fujimoto; Youichirou Higashi; Kentaro Nishida; Takeshi Nishiura; Hiroto Okuda; Kazuki Nagasawa
Peroxynitrite treatment reduces adenosine uptake via the equilibrative nucleoside transporter in rat astrocytes.
Neuroscience letters 2011;498(1):52-6.
2010: Koji Takeuchi; Akiko Tanaka; Shinichi Kato; Kikuko Amagase; Hiroshi Satoh
Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.
Clinica chimica acta; international journal of clinical chemistry 2010;411(7-8):459-66.
2007: Ryo Hatazawa; Mayu Tanigami; N Izumi; K Kamei; Akiko Tanaka; Koji Takeuchi
Prostaglandin E2 stimulates VEGF expression in primary rat gastric fibroblasts through EP4 receptors.
Inflammopharmacology 2007;15(5):214-7.
2007: Ryo Hatazawa; Akiko Tanaka; Mayu Tanigami; Kikuko Amagase; Shinichi Kato; Yasuko Ashida; Koji Takeuchi
Cyclooxygenase-2/prostaglandin E2 accelerates the healing of gastric ulcers via EP4 receptors.
American journal of physiology. Gastrointestinal and liver physiology 2007;293(4):G788-97.
2007: Koji Takeuchi; Akiko Tanaka; Shinichi Kato; Eitaro Aihara; Kikuko Amagase
Effect of (S)-4-(1-(5-chloro-2-(4-fluorophenyoxy)benzamido)ethyl) benzoic acid (CJ-42794), a selective antagonist of prostaglandin E receptor subtype 4, on ulcerogenic and healing responses in rat gastrointestinal mucosa.
The Journal of pharmacology and experimental therapeutics 2007;322(3):903-12.
2007: Aya Yokota; Masaki Taniguchi; Yuka Takahira; Akiko Tanaka; Koji Takeuchi
Dexamethasone damages the rat stomach but not small intestine during inhibition of COX-1.
Digestive diseases and sciences 2007;52(6):1452-61.
2007: Akiko Tanaka; Ryo Hatazawa; Yuka Takahira; Nahoko Izumi; Ludmila Filaretova; Koji Takeuchi
Preconditioning stress prevents cold restraint stress-induced gastric lesions in rats: roles of COX-1, COX-2, and PLA2.
Digestive diseases and sciences 2007;52(2):478-87.
2007: Koji Takeuchi; Ryo Hatazawa; Mayu Tanigami; Akiko Tanaka; Ryoko Ohno; Aya Yokota
Role of endogenous nitric oxide (NO) and NO synthases in healing of indomethacin-induced intestinal ulcers in rats.
Life sciences 2007;80(4):329-36.
2006: Ryo Hatazawa; Ryoko Ohno; Mayu Tanigami; Akiko Tanaka; Koji Takeuchi
Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats.
The Journal of pharmacology and experimental therapeutics 2006;318(2):691-9.
2006: Koji Takeuchi; Aya Yokota; Akiko Tanaka; Yuka Takahira
Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.
Digestive diseases and sciences 2006;51(7):1250-9.
2006: Yuji Mashita; Masaki Taniguchi; Aya Yokota; Akiko Tanaka; Koji Takeuchi
Oral but not parenteral aspirin upregulates COX-2 expression in rat stomachs. a relationship between COX-2 expression and PG deficiency.
Digestion 2006;73(2-3):124-32.
2005: Aya Yokota; Masaki Taniguchi; Yuka Takahira; Akiko Tanaka; Koji Takeuchi
Rofecoxib produces intestinal but not gastric damage in the presence of a low dose of indomethacin in rats.
The Journal of pharmacology and experimental therapeutics 2005;314(1):302-9.
2005: Aya Yokota; Masaki Taniguchi; Akiko Tanaka; Koji Takeuchi
Development of intestinal, but not gastric damage caused by a low dose of indomethacin in the presence of rofecoxib.
Inflammopharmacology 2005;13(1-3):209-16.
2005: Koji Takeuchi; Akiko Tanaka; Yujiro Hayashi; Aya Yokota
COX inhibition and NSAID-induced gastric damage--roles in various pathogenic events.
Current topics in medicinal chemistry 2005;5(5):475-86.
2005: Akiko Tanaka; Masahiro Matsumoto; Yujiro Hayashi; Koji Takeuchi
Functional mechanism underlying cyclooxygenase-2 expression in rat small intestine following administration of indomethacin: relation to intestinal hypermotility.
Journal of gastroenterology and hepatology 2005;20(1):38-45.
2004: Ryoko Ohno; Aya Yokota; Akiko Tanaka; Koji Takeuchi
Induction of small intestinal damage in rats following combined treatment with cyclooxygenase-2 and nitric-oxide synthase inhibitors.
The Journal of pharmacology and experimental therapeutics 2004;310(2):821-7.
2004: Koji Takeuchi; Akiko Tanaka; Yujiro Hayashi; Yoshiaki Kubo
Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility.
Digestive diseases and sciences 2004;49(2):180-7.
2003: Koji Takeuchi; Akiko Tanaka; R Ohno; A Yokota
Role of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2003;54 Suppl 4():165-82.
2002: Akiko Tanaka; Shoko Hase; Tohru Miyazawa; Ryoko Ohno; Koji Takeuchi
Role of cyclooxygenase (COX)-1 and COX-2 inhibition in nonsteroidal anti-inflammatory drug-induced intestinal damage in rats: relation to various pathogenic events.
The Journal of pharmacology and experimental therapeutics 2002;303(3):1248-54.
2002: Ludmila Filaretova; Akiko Tanaka; Tohru Miyazawa; Shinichi Kato; Koji Takeuchi
Mechanisms by which endogenous glucocorticoid protects against indomethacin-induced gastric injury in rats.
American journal of physiology. Gastrointestinal and liver physiology 2002;283(5):G1082-9.
2002: Koji Takeuchi; Akiko Tanaka; Tohru Miyazawa
[Pathogenesis of NSAID-induced gastric mucosal damage--search for primary events and role of COX inhibition].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 2002;99(7):751-9.
2002: Yusaku Komoike; Masanori Takeeda; Akiko Tanaka; Shinichi Kato; Koji Takeuchi
Prevention by parenteral aspirin of indomethacin-induced gastric lesions in rats: mediation by salicylic acid.
Digestive diseases and sciences 2002;47(7):1538-45.
2002: Tomonori Kunikata; Akiko Tanaka; Tohru Miyazawa; Shinichi Kato; Koji Takeuchi
16,16-Dimethyl prostaglandin E2 inhibits indomethacin-induced small intestinal lesions through EP3 and EP4 receptors.
Digestive diseases and sciences 2002;47(4):894-904.
2002: Akiko Tanaka; Hideo Araki; S Hase; Y Komoike; Koji Takeuchi
Up-regulation of COX-2 by inhibition of COX-1 in the rat: a key to NSAID-induced gastric injury.
Alimentary pharmacology & therapeutics 2002;16 Suppl 2():90-101.
2002: Akiko Tanaka; Shoko Hase; Tohru Miyazawa; Koji Takeuchi
Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1: a key to nonsteroidal anti-inflammatory drug-induced intestinal damage.
The Journal of pharmacology and experimental therapeutics 2002;300(3):754-61.
2002: Hideo Araki; Yusaku Komoike; Masahiro Matsumoto; Akiko Tanaka; Koji Takeuchi
Healing of duodenal ulcers is not impaired by indomethacin or rofecoxib, the selective COX-2 inhibitor, in rats.
Digestion 2002;66(3):145-53.
2002: Koji Takeuchi; Tohu Miyazawa; Akiko Tanaka; Shinichi Kato; Tomonori Kunikata
Pathogenic importance of intestinal hypermotility in NSAID-induced small intestinal damage in rats.
Digestion 2002;66(1):30-41.
2001: H Mizoguchi; Yoshihiro Ogawa; Kenji Kanatsu; Akiko Tanaka; Shinichi Kato; Koji Takeuchi
Protective effect of rebamipide on indomethacin-induced intestinal damage in rats.
Journal of gastroenterology and hepatology 2001;16(10):1112-9.
2001: Akiko Tanaka; H Mizoguchi; Shoko Hase; Tohru Miyazawa; Koji Takeuchi
Intestinal protection by lafutidine, a histamine H(2)-receptor antagonist, against indomethacin-induced damage in rats--role of endogenous nitric oxide.
Medical science monitor : international medical journal of experimental and clinical research 2001;7(5):869-77.
2001: Koji Takeuchi; Shinichi Kato; Akiko Tanaka
[Gastrointestinal cytoprotection by prostaglandin E and EP receptor subtypes].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2001;117(4):274-82.
2001: Koji Takeuchi; Akiko Tanaka
[Gastrointestinal sparing anti-inflammatory drugs--COX-2 selective inhibitors and NO-releasing NSAIDs].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica 2001;117(2):138-48.
2001: H Mizoguchi; Shoko Hase; Akiko Tanaka; Koji Takeuchi
Lack of small intestinal ulcerogenecity of nitric oxide-releasing indomethacin, NCX-530, in rats.
Alimentary pharmacology & therapeutics 2001;15(2):257-67.
2001: Koji Takeuchi; Shoko Hase; H Mizoguchi; Yusaku Komoike; Akiko Tanaka
Protection by aspirin of indomethacin-induced small intestinal damage in rats: mediation by salicylic acid.
Journal of physiology, Paris 2001;95(1-6):51-7.
2001: Akiko Tanaka; H Mizoguchi; Tomonori Kunikata; Tohru Miyazawa; Koji Takeuchi
Protection by constitutively formed nitric oxide of intestinal damage induced by indomethacin in rats.
Journal of physiology, Paris 2001;95(1-6):35-41.
2001: Akiko Tanaka; Hideo Araki; Yusaku Komoike; Shoko Hase; Koji Takeuchi
Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs.
Journal of physiology, Paris 2001;95(1-6):21-7.
2001: Shinichi Kato; Yoshihiro Ogawa; Akiko Tanaka; Tomonori Kunikata; Koji Takeuchi
Delayed healing of gastric ulcers in adjuvant arthritis rats: role of acid secretion and basic fibroblast growth factor.
Digestion 2001;63(3):171-9.
2001: Shinichi Kato; Akiko Tanaka; Yoshihiro Ogawa; Kenji Kanatsu; K Seto; T Yoneda; Koji Takeuchi
Effect of polaprezinc on impaired healing of chronic gastric ulcers in adjuvant-induced arthritic rats--role of insulin-like growth factors (IGF)-1.
Medical science monitor : international medical journal of experimental and clinical research 2001;7(1):20-5.
2000: Shinichi Kato; Akiko Tanaka; Tomonori Kunikata; H Mizoguchi; Koji Takeuchi
The roles of nitric oxide and prostaglandins in alterations of ulcerogenic and healing responses in adjuvant-induced arthritic rat stomachs.
Alimentary pharmacology & therapeutics 2000;14 Suppl 1():18-25.
2000: Shinichi Kato; Akiko Tanaka; Tomonori Kunikata; Masakazu Umeda; Koji Takeuchi
Protective effect of lafutidine against indomethacin-induced intestinal ulceration in rats: relation to capsaicin-sensitive sensory neurons.
Digestion 2000;61(1):39-46.
1999: A Konaka; Shinichi Kato; Akiko Tanaka; Tomonori Kunikata; Roman P Korolkiewicz; Koji Takeuchi
Roles of enterobacteria, nitric oxide and neutrophil in pathogenesis of indomethacin-induced small intestinal lesions in rats.
Pharmacological research : the official journal of the Italian Pharmacological Society 1999;40(6):517-24.
1999: H Yamamoto; Akiko Tanaka; Tomonori Kunikata; T Hirata; Shinichi Kato; Koji Takeuchi
Inducible types of cyclooxygenase and nitric oxide synthase in adaptive cytoprotection in rat stomachs.
Journal of physiology, Paris 1999;93(5):405-12.
1999: Akiko Tanaka; Tomonori Kunikata; H Mizoguchi; Shinichi Kato; Koji Takeuchi
Dual action of nitric oxide in pathogenesis of indomethacin-induced small intestinal ulceration in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1999;50(3):405-17.
1999: Shinichi Kato; Akiko Tanaka; Tomonori Kunikata; M Nishijima; Koji Takeuchi
Changes in gastric mucosal ulcerogenic responses in rats with adjuvant arthritis: role of nitric oxide.
Alimentary pharmacology & therapeutics 1999;13(6):833-40.
1999: A Konaka; M Nishijima; Akiko Tanaka; Tomonori Kunikata; Shinichi Kato; Koji Takeuchi
Nitric oxide, superoxide radicals and mast cells in pathogenesis of indomethacin-induced small intestinal lesions in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 1999;50(1):25-38.