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Fujie Tanaka

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TOP 3
Xueyong Zhu; Fujie Tanaka; Richard A Lerner; Carlos F Barbas; Ian A Wilson
Direct observation of an enamine intermediate in amine catalysis.
Hai-Ming Guo; Fujie Tanaka
A fluorogenic aldehyde bearing a 1,2,3-triazole moiety for monitoring the progress of aldol reactions.
Fujie Tanaka
[Creation of enzymes using computdtional de novo design: retro-aldol enzymes].

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All Publications

2009: Xueyong Zhu; Fujie Tanaka; Richard A Lerner; Carlos F Barbas; Ian A Wilson
Direct observation of an enamine intermediate in amine catalysis.
Journal of the American Chemical Society 2009;131(51):18206-7.
2009: Hai-Ming Guo; Fujie Tanaka
A fluorogenic aldehyde bearing a 1,2,3-triazole moiety for monitoring the progress of aldol reactions.
The Journal of organic chemistry 2009;74(6):2417-24.
2009: Fujie Tanaka
[Creation of enzymes using computdtional de novo design: retro-aldol enzymes].
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme 2009;54(3):252-8.
2009: Hai-Ming Guo; Maki Minakawa; Lynn Ueno; Fujie Tanaka
Synthesis and evaluation of a cyclic imine derivative conjugated to a fluorescent molecule for labeling of proteins.
Bioorganic & medicinal chemistry letters 2009;19(4):1210-3.
2008: Fujie Tanaka; Yunfeng Hu; Jori Sutton; Lily Asawapornmongkol; Roberta Fuller; Arthur J Olson; Carlos F Barbas; Richard A Lerner
Selection of phage-displayed peptides that bind to a particular ligand-bound antibody.
Bioorganic & medicinal chemistry 2008;16(11):5926-31.
2008: Hai-Ming Guo; Maki Minakawa; Fujie Tanaka
Fluorogenic imines for fluorescent detection of Mannich-type reactions of phenols in water.
The Journal of organic chemistry 2008;73(10):3964-6.
2008: Haile Zhang; Susumu Mitsumori; Naoto Utsumi; Masanori Imai; Noemi Garcia-Delgado; Maria Mifsud; Klaus Albertshofer; Paul Ha-Yeon Cheong; Kendall N Houk; Fujie Tanaka; Carlos F Barbas
Catalysis of 3-pyrrolidinecarboxylic acid and related pyrrolidine derivatives in enantioselective anti-Mannich-type reactions: importance of the 3-acid group on pyrrolidine for stereocontrol.
Journal of the American Chemical Society 2008;130(3):875-86.
2007: Naoto Utsumi; Masanori Imai; Fujie Tanaka; S S V Ramasastry; Carlos F Barbas
Mimicking aldolases through organocatalysis: syn-selective aldol reactions with protected dihydroxyacetone.
Organic letters 2007;9(17):3445-8.
2007: Fujie Tanaka; Roberta Fuller; Lily Asawapornmongkol; Axel Warsinke; Sarah Gobuty; Carlos F Barbas
Development of a small peptide tag for covalent labeling of proteins.
Bioconjugate chemistry 2007;18(4):1318-24.
2007: Fujie Tanaka; Teresa Jones; Diane Kubitz; Richard A Lerner
Anti-formyl peptide antibodies.
Bioorganic & medicinal chemistry letters 2007;17(7):1943-5.
2007: S S V Ramasastry; Haile Zhang; Fujie Tanaka; Carlos F Barbas
Direct catalytic asymmetric synthesis of anti-1,2-amino alcohols and syn-1,2-diols through organocatalytic anti-Mannich and syn-aldol reactions.
Journal of the American Chemical Society 2007;129(2):288-9.
2007: S S V Ramasastry; Klaus Albertshofer; Naoto Utsumi; Fujie Tanaka; Carlos F Barbas
Mimicking fructose and rhamnulose aldolases: organocatalytic syn-aldol reactions with unprotected dihydroxyacetone.
Angewandte Chemie (International ed. in English) 2007;46(29):5572-5.
2007: Naoto Utsumi; Haile Zhang; Fujie Tanaka; Carlos F Barbas
A way to highly enantiomerically enriched aza-Morita-Baylis-Hillman-type products.
Angewandte Chemie (International ed. in English) 2007;46(11):1878-80.
2006: Haile Zhang; Maria Mifsud; Fujie Tanaka; Carlos F Barbas
3-Pyrrolidinecarboxylic acid for direct catalytic asymmetric anti-Mannich-type reactions of unmodified ketones.
Journal of the American Chemical Society 2006;128(30):9630-1.
2006: Fujie Tanaka; Roberta Fuller
Control of function of a small peptide by a protein.
Bioorganic & medicinal chemistry letters 2006;16(15):4059-62.
2006: Naidu S Chowdari; Moballigh Ahmad; Klaus Albertshofer; Fujie Tanaka; Carlos F Barbas
Expedient synthesis of chiral 1,2- and 1,4-diamines: protecting group dependent regioselectivity in direct organocatalytic asymmetric Mannich reactions.
Organic letters 2006;8(13):2839-42.
2006: Jeff T Suri; Susumu Mitsumori; Klaus Albertshofer; Fujie Tanaka; Carlos F Barbas
Dihydroxyacetone variants in the organocatalytic construction of carbohydrates: mimicking tagatose and fuculose aldolases.
The Journal of organic chemistry 2006;71(10):3822-8.
2006: Susumu Mitsumori; Haile Zhang; Paul Ha-Yeon Cheong; Kendall N Houk; Fujie Tanaka; Carlos F Barbas
Direct asymmetric anti-Mannich-type reactions catalyzed by a designed amino acid.
Journal of the American Chemical Society 2006;128(4):1040-1.
2005: Fujie Tanaka; Roberta Fuller; Carlos F Barbas
Development of small designer aldolase enzymes: catalytic activity, folding, and substrate specificity.
Biochemistry 2005;44(20):7583-92.
2005: Fujie Tanaka
Development of protein, peptide, and small molecule catalysts using catalysis-based selection strategies.
Chemical record (New York, N.Y.) 2005;5(5):276-85.
2004: Xueyong Zhu; Fujie Tanaka; Yunfeng Hu; Andreas Heine; Roberta Fuller; Guofu Zhong; Arthur J Olson; Richard A Lerner; Carlos F Barbas; Ian A Wilson
The origin of enantioselectivity in aldolase antibodies: crystal structure, site-directed mutagenesis, and computational analysis.
Journal of molecular biology 2004;343(5):1269-80.
2004: Subhash C Sinha; Lian-Sheng Li; Shin-Ichi Watanabe; Eiton Kaltgrad; Fujie Tanaka; Christoph Rader; Richard A Lerner; Carlos F Barbas
Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy.
Chemistry (Weinheim an der Bergstrasse, Germany) 2004;10(21):5467-72.
2004: Rajeswari Thayumanavan; Fujie Tanaka; Carlos F Barbas III
Direct organocatalytic asymmetric aldol reactions of alpha-amino aldehydes: expedient syntheses of highly enantiomerically enriched anti-beta-hydroxy-alpha-amino acids.
Organic letters 2004;6(20):3541-4.
2004: Fujie Tanaka; Nobuyuki Mase; Carlos F Barbas
Determination of cysteine concentration by fluorescence increase: reaction of cysteine with a fluorogenic aldehyde.
Chemical communications (Cambridge, England) 2004;(15):1762-3.
2004: Wolfgang Notz; Fujie Tanaka; Carlos F Barbas
Enamine-based organocatalysis with proline and diamines: the development of direct catalytic asymmetric Aldol, Mannich, Michael, and Diels-alder reactions.
Accounts of chemical research 2004;37(8):580-91.
2004: Nobuyuki Mase; Rajeswari Thayumanavan; Fujie Tanaka; Carlos F Barbas
Direct asymmetric organocatalytic Michael reactions of alpha,alpha-disubstituted aldehydes with beta-nitrostyrenes for the synthesis of quaternary carbon-containing products.
Organic letters 2004;6(15):2527-30.
2004: Fujie Tanaka; Fabiola Flores; Diane Kubitz; Richard A Lerner; Carlos F Barbas
Antibody-catalyzed aminolysis of a chloropyrimidine derivative.
Chemical communications (Cambridge, England) 2004;(10):1242-3.
2004: Fujie Tanaka; Nobuyuki Mase; Carlos F Barbas
Design and use of fluorogenic aldehydes for monitoring the progress of aldehyde transformations.
Journal of the American Chemical Society 2004;126(12):3692-3.
2004: Fujie Tanaka; Roberta Fuller; Hyunbo Shim; Richard A Lerner; Carlos F Barbas
Evolution of aldolase antibodies in vitro: correlation of catalytic activity and reaction-based selection.
Journal of molecular biology 2004;335(4):1007-18.
2003: Wolfgang Notz; Fujie Tanaka; Shin-Ichi Watanabe; Naidu S Chowdari; James M Turner; Rajeswari Thayumanavan; Carlos F Barbas
The direct organocatalytic asymmetric mannich reaction: unmodified aldehydes as nucleophiles.
The Journal of organic chemistry 2003;68(25):9624-34.
2003: Nobuyuki Mase; Fujie Tanaka; Carlos F Barbas
Rapid fluorescent screening for bifunctional amine-acid catalysts: efficient syntheses of quaternary carbon-containing aldols under organocatalysis.
Organic letters 2003;5(23):4369-72.
2003: Fujie Tanaka; Rajeswari Thayumanavan; Carlos F Barbas
Fluorescent detection of carbon-carbon bond formation.
Journal of the American Chemical Society 2003;125(28):8523-8.
2002: Shin-ichi Watanabe; Armando Córdova; Fujie Tanaka; Carlos F Barbas
One-pot asymmetric synthesis of beta-cyanohydroxymethyl alpha-amino acid derivatives: formation of three contiguous stereogenic centers.
Organic letters 2002;4(25):4519-22.
2002: Fujie Tanaka
Catalytic antibodies as designer proteases and esterases.
Chemical reviews 2002;102(12):4885-906.
2002: Fujie Tanaka; Carlos F Barbas
Reactive immunization: a unique approach to catalytic antibodies.
Journal of immunological methods 2002;269(1-2):67-79.
2002: Fujie Tanaka; Carlos F Barbas
A modular assembly strategy for improving the substrate specificity of small catalytic peptides.
Journal of the American Chemical Society 2002;124(14):3510-1.
2002: Armando Córdova; Shin-ichi Watanabe; Fujie Tanaka; Wolfgang Notz; Carlos F Barbas
A highly enantioselective route to either enantiomer of both alpha- and beta-amino acid derivatives.
Journal of the American Chemical Society 2002;124(9):1866-7.
2001: Fujie Tanaka; Lisa Kerwin; Diane Kubitz; Richard A Lerner; Carlos F Barbas
Visualizing antibody-catalyzed retro-aldol-retro-Michael reactions.
Bioorganic & medicinal chemistry letters 2001;11(22):2983-6.
2000: A Karlstrom; Guofu Zhong; Christoph Rader; Nicholas A Larsen; Andreas Heine; Roberta Fuller; Benjamin List; Fujie Tanaka; Ian A Wilson; Carlos F Barbas; Richard A Lerner
Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task.
Proceedings of the National Academy of Sciences of the United States of America 2000;97(8):3878-83.